AU9210498A - 5',5'-linked oligomers having anti-thrombin activity - Google Patents

5',5'-linked oligomers having anti-thrombin activity

Info

Publication number
AU9210498A
AU9210498A AU92104/98A AU9210498A AU9210498A AU 9210498 A AU9210498 A AU 9210498A AU 92104/98 A AU92104/98 A AU 92104/98A AU 9210498 A AU9210498 A AU 9210498A AU 9210498 A AU9210498 A AU 9210498A
Authority
AU
Australia
Prior art keywords
thrombin activity
linked oligomers
oligomers
linked
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU92104/98A
Inventor
Norbert W Bischofberger
Chris A. Buhr
Joseph P. Dougherty
Brian C. Froehler
Arnold J. Gutierrez
Gong-Xin He
Regan G. Shea
Sundaramoorthi Swaminathan
Matthew A. Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AU9210498A publication Critical patent/AU9210498A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU92104/98A 1997-08-29 1998-08-28 5',5'-linked oligomers having anti-thrombin activity Abandoned AU9210498A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5736497P 1997-08-29 1997-08-29
US60057364 1997-08-29
PCT/US1998/017913 WO1999010365A2 (en) 1997-08-29 1998-08-28 5',5'-linked oligomers having anti-thrombin activity

Publications (1)

Publication Number Publication Date
AU9210498A true AU9210498A (en) 1999-03-16

Family

ID=22010124

Family Applications (1)

Application Number Title Priority Date Filing Date
AU92104/98A Abandoned AU9210498A (en) 1997-08-29 1998-08-28 5',5'-linked oligomers having anti-thrombin activity

Country Status (2)

Country Link
AU (1) AU9210498A (en)
WO (1) WO1999010365A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103209987B (en) 2010-09-22 2017-06-06 艾丽奥斯生物制药有限公司 Substituted nucleotide analog
AU2012358804B2 (en) 2011-12-22 2018-04-19 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
WO2013142124A1 (en) 2012-03-21 2013-09-26 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
EP2827876A4 (en) 2012-03-22 2015-10-28 Alios Biopharma Inc Pharmaceutical combinations comprising a thionucleotide analog

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06508022A (en) * 1991-02-21 1994-09-14 ギリアド　サイエンシズ，インコーポレイテッド Biomolecule-specific aptamers and production methods

Also Published As

Publication number Publication date
WO1999010365A3 (en) 1999-05-14
WO1999010365A2 (en) 1999-03-04

Similar Documents

Publication Publication Date Title
DE69941083D1 (en) 12,13-cyclopropan-epothilonderivate
ZA972685B (en) Medicaments.
PL332040A1 (en) Substitution 6,5-heterobicyclic derivatives
PL331988A1 (en) Substitution 6,6-heterobicyclic derivatives
AU1745699A (en) Catalyst deactivation
ZA989061B (en) Medicaments.
AU6399798A (en) New catalysts
AU2681895A (en) 8-aryl-1,6-naphthyridin-5-ones
DE69723848D1 (en) 3-descladinose-2,3-anhydroerythromycin-derivate
HU9802807D0 (en) 1,3,8-triazo-spiro[4,5]decan-4-on derivatives
DE59804842D1 (en) Aliphatische, emissionsarme, sinterfähige thermoplastische polyurethanformmassen
AU3858497A (en) Catalyst recovery
AU4720397A (en) Terpenylated diketopiperazines, (drimentines)
AU9210498A (en) 5',5'-linked oligomers having anti-thrombin activity
AU2964899A (en) 2,4-dioxo-5-arylidenimino-1,3-pyrimidines
AUPP003297A0 (en) 4,5-diaryloxazole compounds
AU6904698A (en) Herbicidal 3,5-difluoropyridines
AU3150395A (en) Retroviral protease inhibiting 1,2,4-triazacycloheptanes
ZA972302B (en) 1,25-Dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives.
AU3273199A (en) Semirigid, position-correctable, collision-energy-dissipating guardrail
AU2137095A (en) Heterocyclyl-1,3,4-thiadiazolyloxyacetamides
AU6423298A (en) 4-arylmethylene-1,4-dihydro-2h-azine derivatives
AU3196000A (en) 3,3'-diketotrehalose
AU3006797A (en) Substituted 1, 3-benzodioxoles
AU1303897A (en) Herbicidal 1,2,4,6-thiatriazines

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase