AU8857991A - Polypeptides having human dopaminergic receptor activity, nucleic acids coding for said polypeptides and uses thereof for screening active substances on said polypeptides - Google Patents

Polypeptides having human dopaminergic receptor activity, nucleic acids coding for said polypeptides and uses thereof for screening active substances on said polypeptides

Info

Publication number
AU8857991A
AU8857991A AU88579/91A AU8857991A AU8857991A AU 8857991 A AU8857991 A AU 8857991A AU 88579/91 A AU88579/91 A AU 88579/91A AU 8857991 A AU8857991 A AU 8857991A AU 8857991 A AU8857991 A AU 8857991A
Authority
AU
Australia
Prior art keywords
polypeptides
dopaminergic receptor
nucleic acids
receptor
receptor activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU88579/91A
Inventor
Bruno Giros
Marie-Pascale Martres
Jean-Charles Schwartz
Pierre Sokoloff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Publication of AU8857991A publication Critical patent/AU8857991A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Novel polypeptides are provided having dopaminergic receptor activity and containing the 400-aminoacid sequence of figure 1 or a fragment thereof, said fragment being such that: either it nevertheless contains the sites included in the sequence and whose presence is required if, when said fragment is exposed on the surface of a cell, it is specifically and quantitatively to bond the dopamine, its agonists or its antagonists, for example by means of a radioactive ligand; or it may be recognized by antibodies which also recognize the abovementioned sequence of 400 aminoacids but do not recognize either the D-1 dopaminergic receptor, the D-2 dopaminergic receptor or the rat D-3 receptor; or else it may generate antibodies which recognize the abovementioned sequence of 446 aminoacids but do not recognize either the D-1 dopaminergic receptor, the D-2 dopaminergic receptor, or the rat D-3 receptor.
AU88579/91A 1990-11-06 1991-10-16 Polypeptides having human dopaminergic receptor activity, nucleic acids coding for said polypeptides and uses thereof for screening active substances on said polypeptides Abandoned AU8857991A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9013731 1990-11-06
FR9013731A FR2668771B1 (en) 1990-11-06 1990-11-06 NUCLEIC ACIDS ENCODING POLYPEPTIDES HAVING HUMAN DOPAMINERGIC RECEPTOR ACTIVITY AND THE USE OF SUCH POLYPEPTIDES FOR SCREENING ACTIVE SUBSTANCES ON THESE POLYPEPTIDES.

Publications (1)

Publication Number Publication Date
AU8857991A true AU8857991A (en) 1992-05-26

Family

ID=9401888

Family Applications (1)

Application Number Title Priority Date Filing Date
AU88579/91A Abandoned AU8857991A (en) 1990-11-06 1991-10-16 Polypeptides having human dopaminergic receptor activity, nucleic acids coding for said polypeptides and uses thereof for screening active substances on said polypeptides

Country Status (9)

Country Link
EP (1) EP0507908B1 (en)
JP (1) JPH05503219A (en)
AT (1) ATE180788T1 (en)
AU (1) AU8857991A (en)
CA (1) CA2072874C (en)
DE (1) DE69131289T2 (en)
ES (1) ES2134781T3 (en)
FR (1) FR2668771B1 (en)
WO (1) WO1992007937A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425143A1 (en) 1994-07-15 1996-01-18 Basf Ag Substituted pyrimidine compounds and their use
DE19600934A1 (en) 1996-01-12 1997-07-17 Basf Ag Substituted aza and diazacycloheptane and cyclooctane compounds and their use
US20010053849A1 (en) * 1999-06-16 2001-12-20 Mary Jeanne Kreek Plural biological sample arrays, and preparation and uses thereof
EP1683790A1 (en) 2005-01-24 2006-07-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) 3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands

Also Published As

Publication number Publication date
CA2072874C (en) 2004-12-28
EP0507908A1 (en) 1992-10-14
ES2134781T3 (en) 1999-10-16
FR2668771B1 (en) 1995-03-17
WO1992007937A1 (en) 1992-05-14
JPH05503219A (en) 1993-06-03
EP0507908B1 (en) 1999-06-02
CA2072874A1 (en) 1992-05-07
DE69131289D1 (en) 1999-07-08
DE69131289T2 (en) 1999-12-16
ATE180788T1 (en) 1999-06-15
FR2668771A1 (en) 1992-05-07

Similar Documents

Publication Publication Date Title
PT100122A (en) POLYPSEPTIDES CORRESPONDING TO RECEPTOR-INDUCED LIGACATION LOCATIONS (RIBS), ANTI-RIBS ANTIBODIES, AND ANTICORN DETECTION AND INSULATION PROCESSES
TW324064B (en) Receptor-based screening method for amylin agonists and antagonists
ES8607564A1 (en) Antibodies to human interleukin-2 induced by synthetic polypeptides.
GB2209757A (en) Altered antibodies
IL94039A0 (en) Antibodies to anti-cytotoxic proteins
DE69334100D1 (en) ELK LIGAND, A CYTOKIN
PT835266E (en) MODIFIED / CHEMICAL SURFACES AND ITS USE
FI912960A (en) BIOLOGICALLY ACTIVE REAGENTS FRAMSTAELLDA AV EN POLYMER INNEHAOLLANDE EN KARBOXYLGRUPP, ANALYTICAL ELEMENT OCH DERAS ANVAENDNING.
PT895592E (en) BIODETECTOR DEVICE AND METHOD
DE69230525T2 (en) Technetium-99m labeled polypeptides for image formation
EP0344940A3 (en) Antibodies to human papillomavirus latent proteins, diagnostic systems and methods
TR200002257T2 (en) Nuclear receptor ligands and ligand binding domains.
ATE353906T1 (en) CD27 LIGAND
HK1013844A1 (en) T cell receptor-specific for antigen polypeptides and related polynucleotides
EP0577605A4 (en)
TW218037B (en)
EP0446273A4 (en) Monoclonal antibodies to feline-t-lymphotropic lentivirus
IT8919051A0 (en) WATER-RESISTANT FUEL AGGLOMERATE, PROCEDURE FOR ITS PREPARATION AND COMPOSITION OF MATERIALS USED IN SUCH PROCEDURE.
GB2255637B (en) Separation method
AU8857991A (en) Polypeptides having human dopaminergic receptor activity, nucleic acids coding for said polypeptides and uses thereof for screening active substances on said polypeptides
RU93005126A (en) GELONIN, DNA
DE69121861D1 (en) PEPTIDES FROM SM-D-ANTIGEN, THEIR USE FOR DETECTING DISSEMINATED LUPUS ERYTHEMATEUX
ATE184286T1 (en) HGPIIB FRAGMENTS AND THEIR USE IN IN VITRO METHODS FOR DETERMINING THROMBOTIC EVENTS OCCURRING IN VIVO
AU3106589A (en) Agent, for immunochemical assays, containing amine oxides
DE60018785D1 (en) IMMUNOASSAY OF C-PEPTIDE-CONTAINING CONTAMINANTS IN RECOMBINANT HUMAN INSULIN