AU8808798A - Method for the ex-vivo expansion of hematopoietic stem cells - Google Patents

Method for the ex-vivo expansion of hematopoietic stem cells

Info

Publication number
AU8808798A
AU8808798A AU88087/98A AU8808798A AU8808798A AU 8808798 A AU8808798 A AU 8808798A AU 88087/98 A AU88087/98 A AU 88087/98A AU 8808798 A AU8808798 A AU 8808798A AU 8808798 A AU8808798 A AU 8808798A
Authority
AU
Australia
Prior art keywords
stem cells
hematopoietic stem
vivo expansion
vivo
expansion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU88087/98A
Inventor
Lorenza Lazzari
Paolo Rebulla
Girolamo Sirchia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dompe SpA
Original Assignee
Dompe SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe SpA filed Critical Dompe SpA
Publication of AU8808798A publication Critical patent/AU8808798A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU88087/98A 1997-08-07 1998-08-05 Method for the ex-vivo expansion of hematopoietic stem cells Abandoned AU8808798A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI97A1898 1997-08-07
IT97MI001898A IT1293827B1 (en) 1997-08-07 1997-08-07 METHOD FOR EX VIVO EXPANSION OF HEMATOPOIETIC STEM CELLS
PCT/EP1998/004882 WO1999007831A1 (en) 1997-08-07 1998-08-05 Method for the ex-vivo expansion of hematopoietic stem cells

Publications (1)

Publication Number Publication Date
AU8808798A true AU8808798A (en) 1999-03-01

Family

ID=11377736

Family Applications (1)

Application Number Title Priority Date Filing Date
AU88087/98A Abandoned AU8808798A (en) 1997-08-07 1998-08-05 Method for the ex-vivo expansion of hematopoietic stem cells

Country Status (3)

Country Link
AU (1) AU8808798A (en)
IT (1) IT1293827B1 (en)
WO (1) WO1999007831A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1753101A (en) * 1999-10-29 2001-05-14 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Method of in vitro T cell differentiation of CD34+ progenitor cells
US20050106127A1 (en) * 2001-11-09 2005-05-19 Morey Kraus Production of cell suspensions
DE10158680B4 (en) * 2001-11-30 2004-04-08 Universitätsklinikum Hamburg-Eppendorf Process for ex vivo expansion and differentiation of multipotent stem cells
DE10227611A1 (en) * 2002-06-20 2004-01-15 Bionethos Holding Gmbh Replication and differentiation of cells in vitro, useful e.g. for wound healing and tissue reconstruction, uses specific growth factors to initiate, end and structurally control growth
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
CA2863795A1 (en) 2012-02-13 2013-08-22 Gamida-Cell Ltd. Culturing of mesenchymal stem cells
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ307995A3 (en) * 1993-05-24 1996-10-16 Immunex Corp Ligands for flt3 receptors
US6060052A (en) * 1995-10-30 2000-05-09 Systemix, Inc. Methods for use of Mpl ligands with primitive human hematopoietic stem cells

Also Published As

Publication number Publication date
WO1999007831A1 (en) 1999-02-18
IT1293827B1 (en) 1999-03-10
ITMI971898A1 (en) 1999-02-07

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