AU8553891A - 1-(2-arylethyl)-pyrrolidines - Google Patents
1-(2-arylethyl)-pyrrolidinesInfo
- Publication number
- AU8553891A AU8553891A AU85538/91A AU8553891A AU8553891A AU 8553891 A AU8553891 A AU 8553891A AU 85538/91 A AU85538/91 A AU 85538/91A AU 8553891 A AU8553891 A AU 8553891A AU 8553891 A AU8553891 A AU 8553891A
- Authority
- AU
- Australia
- Prior art keywords
- arylethyl
- pyrrolidines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4034785A DE4034785A1 (en) | 1990-11-02 | 1990-11-02 | 1- (2-arylethyl) pyrrolidine |
DE4034785 | 1990-11-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
AU8553891A true AU8553891A (en) | 1992-05-07 |
Family
ID=6417469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU85538/91A Abandoned AU8553891A (en) | 1990-11-02 | 1991-10-02 | 1-(2-arylethyl)-pyrrolidines |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0483580A3 (en) |
JP (1) | JPH04264067A (en) |
KR (1) | KR920009791A (en) |
AU (1) | AU8553891A (en) |
CA (1) | CA2054648A1 (en) |
CS (1) | CS332591A3 (en) |
DE (1) | DE4034785A1 (en) |
HU (1) | HUT61727A (en) |
PT (1) | PT99383A (en) |
ZA (1) | ZA918716B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU662051B2 (en) * | 1992-05-09 | 1995-08-17 | Tioga Pharmaceuticals, Inc. | Arylacetamides |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994018165A1 (en) * | 1993-02-12 | 1994-08-18 | Pfizer Inc. | Sulfonamide compounds as opioid k-receptor agonists |
WO1996006078A1 (en) * | 1994-08-24 | 1996-02-29 | Pfizer Pharmaceuticals Inc. | N-(2-(pyrrolidinyl-1)-1-phenylethyl)acetamides as kappa receptor antagonists |
DE19523502A1 (en) * | 1995-06-28 | 1997-01-02 | Merck Patent Gmbh | Kappa opiate agonists for inflammatory bowel diseases |
MX9701042A (en) * | 1996-02-07 | 1998-05-31 | Pfizer | Hydroxamic acid compounds. |
US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US6303611B1 (en) * | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
US5646151A (en) * | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
TNSN97092A1 (en) | 1996-09-18 | 1999-12-31 | Agouron Pharma | Metal protein enzyme inhibitors and pharmaceutical formulations containing these inhibitors and their pharmacological use and methods and intermediates useful for preparing the aforementioned formulations. |
BR9810706A (en) * | 1997-07-14 | 2000-08-08 | Adolor Corp | Process for the prevention or treatment of itching in a mammal in need of such prevention or treatment |
US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
DE19827633A1 (en) * | 1998-04-20 | 1999-10-21 | Merck Patent Gmbh | Production of N-methyl-N-(1-phenyl-2-(3-hydroxypyrrolidino)ethyl)-2,2-diphenylacetamide enantiomers, e.g. with antiinflammatory, analgesic and diuretic activity |
JP2005508851A (en) | 2001-04-30 | 2005-04-07 | ファイザー・プロダクツ・インク | Method for preparing hydroxypyrrolidinylethylamine compounds useful as kappa agonists |
ATE429226T1 (en) | 2002-05-17 | 2009-05-15 | Tioga Pharmaceuticals Inc | USE OF COMPOUNDS ACTIVE AS SELECTIVE OPIATE RECEPTOR MODULATORS |
US6992193B2 (en) | 2003-06-10 | 2006-01-31 | Adolor Corporation | Sulfonylamino phenylacetamide derivatives and methods of their use |
DE10331723A1 (en) * | 2003-07-11 | 2005-06-16 | Merck Patent Gmbh | Kappa agonists |
RU2441655C2 (en) | 2007-03-30 | 2012-02-10 | Тиога Фармасьютикалз Инк. | Kappa-opioid agonists for treatment of diarrhea-prevailing irritable bowel syndrome and alternate irritable bowel syndrome |
EP2361244B1 (en) | 2008-11-24 | 2013-07-10 | Council of Scientific & Industrial Research | A process for the preparation of optically active n-benzyl-3 hydroxypyrrolidines |
JP6138169B2 (en) * | 2012-03-05 | 2017-05-31 | ドクター レディズ ラボラトリーズ リミテッド | Substituted heterocyclic acetamides as kappa opioid receptor (KOR) agonists |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT376669B (en) * | 1982-11-26 | 1984-12-27 | Laevosan Gmbh & Co Kg | METHOD FOR THE PRODUCTION OF NEW THIENYL ACETATE DERIVATIVES AND PHARMACEUTICALLY COMPATIBLE ACID ADDITION SALTS THEREOF |
GB8618188D0 (en) * | 1986-07-25 | 1986-09-03 | Ici Plc | Diamine compounds |
EP0261842B1 (en) * | 1986-09-17 | 1990-11-22 | Dr. Lo. Zambeletti S.p.A. | N1-acylated-(1-(phenyl or benzyl))-1,2-ethylene diamines |
DE3935371A1 (en) * | 1988-12-23 | 1990-07-05 | Merck Patent Gmbh | NITROGENED RING CONNECTIONS |
-
1990
- 1990-11-02 DE DE4034785A patent/DE4034785A1/en not_active Withdrawn
-
1991
- 1991-10-02 AU AU85538/91A patent/AU8553891A/en not_active Abandoned
- 1991-10-14 EP EP19910117502 patent/EP0483580A3/en not_active Withdrawn
- 1991-10-30 PT PT99383A patent/PT99383A/en not_active Application Discontinuation
- 1991-10-31 CA CA002054648A patent/CA2054648A1/en not_active Abandoned
- 1991-11-01 HU HU913448A patent/HUT61727A/en unknown
- 1991-11-01 JP JP3313182A patent/JPH04264067A/en active Pending
- 1991-11-01 CS CS913325A patent/CS332591A3/en unknown
- 1991-11-01 ZA ZA918716A patent/ZA918716B/en unknown
- 1991-11-01 KR KR1019910019396A patent/KR920009791A/en not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU662051B2 (en) * | 1992-05-09 | 1995-08-17 | Tioga Pharmaceuticals, Inc. | Arylacetamides |
Also Published As
Publication number | Publication date |
---|---|
HU913448D0 (en) | 1992-01-28 |
JPH04264067A (en) | 1992-09-18 |
PT99383A (en) | 1992-09-30 |
ZA918716B (en) | 1992-08-26 |
KR920009791A (en) | 1992-06-25 |
EP0483580A3 (en) | 1992-09-02 |
HUT61727A (en) | 1993-03-01 |
EP0483580A2 (en) | 1992-05-06 |
CA2054648A1 (en) | 1992-05-03 |
DE4034785A1 (en) | 1992-05-07 |
CS332591A3 (en) | 1992-05-13 |
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