AU8023000B2 - - Google Patents

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Publication number

AU8023000B2

AU8023000B2 AU8023000B2 AU 8023000 B2 AU8023000 B2 AU 8023000B2 AU 8023000 B2 AU8023000 B2 AU 8023000B2

Authority

AU

Australia

Prior art keywords

hyaff

composition

rhbmp

hyaluronic acid

gel

Prior art date

2004-06-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 239000000203 mixture Substances 0.000 claims description 43
• 108090000623 proteins and genes Proteins 0.000 claims description 43
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• 239000001506 calcium phosphate Substances 0.000 claims description 38
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 38
• 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 38
• 229940078499 tricalcium phosphate Drugs 0.000 claims description 38
• 235000019731 tricalcium phosphate Nutrition 0.000 claims description 38
• 230000002188 osteogenic effect Effects 0.000 claims description 33
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• 229920002674 hyaluronan Polymers 0.000 claims description 16
• 229960003160 hyaluronic acid Drugs 0.000 claims description 16
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 15
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• XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
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