AU7903300A - Ligand and complex for catalytically bleaching a substrate - Google Patents

Description

WO 01/16272 PCT/EPOO/08144 LIGAND AND COMPLEX FOR CATALYTICALLY BLEACHING A SUBSTRATE FIELD OF INVENTION This invention relates to'a class of ligand or complex 5 useful as catalysts for catalytically bleaching substrates with atmospheric oxygen, and as catalysts in the treatment of textiles such as laundry fabrics whereby bleaching by atmospheric oxygen is catalysed after the treatment. 10 BACKGROUND OF INVENTION Peroxygen bleaches are well known for their ability to remove stains from substrates. Traditionally, the substrate is subjected to hydrogen peroxide, or to substances which can generate hydroperoxyl radicals, such as inorganic or 15 organic peroxides. Generally, these systems must be activated. One method of activation is to employ wash temperatures of 60*C or higher. However, these high temperatures often lead to inefficient cleaning, and can also cause premature damage to the substrate. 20 A preferred approach to generating hydroperoxyl bleach radicals is the use of inorganic peroxides coupled with organic precursor compounds. These systems are employed for many commercial laundry powders. For example, various 25 European systems are based on tetraacetyl ethylenediamine (TAED) as the organic precursor coupled with sodium perborate or sodium percarbonate, whereas in the United States laundry bleach products are typically based on sodium nonanoyloxybenzenesulfonate (SNOBS) as the organic precursor 30 coupled with sodium perborate.

WO 01/16272 PCT/EPOO/08144 -2 Precursor systems are generally effective but still exhibit several disadvantages. For example, organic precursors are moderately sophisticated molecules requiring multi-step manufacturing processes resulting in high capital costs. 5 Also, precursor systems have large formulation space requirements so that a significant proportion of a laundry powder must be devoted to the bleach components, leaving less room for other active ingredients and complicating the development of concentrated powders. Moreover, precursor .0 systems do not bleach very efficiently in countries where consumers have wash habits entailing low dosage, short wash times, cold temperatures and low wash liquor to substrate ratios. L5 Alternatively, or additionally, hydrogen peroxide and peroxy systems can be activated by bleach catalysts, such as by complexes of iron and the ligand N4Py (i.e. N, N bis(pyridin-2-yl-methyl)-bis(pyridin-2-yl)methylamine) disclosed in W095/34628, or the ligand Tpen (i.e. N, N, N', 20 N'-tetra(pyridin-2-yl-methyl)ethylenediamine) disclosed in W097/48787. According to these publications, molecular oxygen may be used as the oxidant as an alternative to peroxide generating systems. However, no role in catalysing bleaching by atmospheric oxygen in an aqueous medium is 25 reported. It has long been thought desirable to be able to use atmospheric oxygen (air) as the source for a bleaching species, as this would avoid the need for costly 30 hydroperoxyl generating systems. Unfortunately, air as such is kinetically inert towards bleaching substrates and WO 01/16272 PCT/EPOO/08144 -3 exhibits no bleaching ability. Recently some progress has been made in this area. For example, WO 97/38074 reports the use of air for oxidising stains on fabrics by bubbling air through an aqueous solution containing an aldehyde and a 5 radical initiator. A broad range of aliphatic, aromatic and heterocyclic aldehydes is reported to be useful, particularly para-substituted aldehydes such as 4-methyl-, 4-ethyl- and 4-isopropyl benzaldehyde, whereas the range of initiators disclosed includes N-hydroxysuccinimide, various 0 peroxides and transition metal coordination complexes. However, although this system employs molecular oxygen from the air, the aldehyde component and radical initiators such as peroxides are consumed during the bleaching process. .5 These components must therefore be included in the composition in relatively high amounts so as not to become depleted before completion of the bleaching process in the wash cycle. Moreover, the spent components represent a waste of resources as they can no longer participate in the ?0 bleaching process. Accordingly, it would be desirable to be able to provide a bleaching system based on atmospheric oxygen or air that does not rely primarily on hydrogen peroxide or a 25 hydroperoxyl generating system, and that does not require the presence of organic components such as aldehydes that are consumed in the process. Moreover, it would be desirable to provide such a bleaching system that is effective in aqueous medium. 30 WO 01/16272 PCT/EPOO/08144 -4 It may also be noted that the known art teaches a bleaching effect only as long as the substrate is being subjected to the bleaching treatment. Thus, there is no expectation that hydrogen peroxide or peroxy bleach systems could continue to 5 provide a bleaching effect on a treated substrate, such as a laundry fabric after washing and drying, since the bleaching species themselves or any activators necessary for the bleaching systems would be assumed to be removed from the substrate, or consumed or deactivated, on completing the LO wash cycle and drying. It would be therefore also be desirable to be able to treat a textile such that, after the treatment is completed, a bleaching effect is observed on the textile. Furthermore, 15 it would be desirable to be able to provide a bleach treatment for textiles such as laundry fabrics whereby residual bleaching occurs when the treated fabric has been treated and is dry. 20 SUMMARY OF INVENTION We have found a novel class of ligand or complex that is surprisingly effective in catalysing the bleaching of substrates using atmospheric oxygen or air. 25 Accordingly, in a first aspect, the present invention provides of the general formula: WO 01/16272 PCT/EPOO/08144 -5 R1 Q-sNN N-Q 2

-R

2 Q N'Q

Q

3 wherein

R

1 , R 2 , and R 3 independently represent a group selected from hydrogen, hydroxyl, halogen, -NH-C(NH)NH 2 , -R and -OR, 5 wherein R= alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl or a carbonyl derivative group, R being optionally substituted by one or more functional groups E, further specified below; Q independently represents a group selected from C2-3 o alkylene optionally substituted by H, benzyl or Ci- 8 -alkyl; and Qi, Q2 and Q3 independently represent linking groups, further specified below, provided that two of R 1 , R 2 and R 3 are coordinating 5 groups and one of R 1 , R 2 and R 3 is a non-coordinating group, and with the proviso that the following ligands are excluded: 1,4-bis(N-methyl-imidazol-2ylmethyl)-1,4,7 0 triazacyclononane; 1,4-bis(N-methyl-imidazol-2ylmethyl)-7-acetate-1,4,7 triazacyclononane; 1,4-bis(pyridin-2-ylmethyl)-7-ethyl-1,4,7-triazacyclononane; 1,4-bis(quinolin-2-ylmethyl)-7-ethyl-1,4,7 25 triazacyclononane; 1,4-bis(pyrazol-1-ylmethyl)-7-ethyl-1,4,7-triazacyclononane; WO 01/16272 PCT/EPOO/08144 -6 1,4-bis(3,5-dimethylpyrazol-1-ylmethyl)-7-ethyl-1,4,7 triazacyclononane; 1,4-bis(N-methylimidazol-2-ylmethyl)-7-ethyl-1,4,7 triazacyclononane; 5 1,4-bis(N-isopropylacetamido)-7-ethyl-1,4,7 triazacyclononane; and 1,4-bis(N-methylacetamido)-7-ethyl-1,4,7-triazacyclononane. In a second aspect, the present invention provides a complex 10 of the ligand and a transition metal. An advantage of the class of ligand and complex according to the present invention is that the complex can catalyse bleaching of a substrate by atmospheric oxygen, thus 15 permitting its use in a medium such as an aqueous medium that is substantially devoid of peroxygen bleach or a peroxy-based or -generating bleach system. We have also found that complexes of this class are surprisingly effective in catalysing bleaching of the substrate by 20 atmospheric oxygen after treatment of the substrate. Advantageously, the ligand or complex according to the present invention permits all or the majority of the bleaching species in the medium (on an equivalent weight 25 basis) to be derived from atmospheric oxygen. Thus, the medium can be made wholly or substantially devoid of peroxygen bleach or a peroxy-based or -generating bleach system. Furthermore, the complex is a catalyst for the bleaching process and, as such, is not consumed but can 30 continue to participate in the bleaching process. Thus, the ligand or complex can provide a catalytically activated WO 01/16272 PCT/EPOO/08144 -7 bleaching system which is based on atmospheric oxygen, is therefore both cost-effective and environmentally friendly. Moreover, a bleaching system can be provided that is operable under unfavourable wash conditions which include 5 low temperatures, short contact times and low dosage requirements. Furthermore, the catalyst is effective in an aqueous medium and is therefore particularly applicable to bleaching of laundry fabrics. Therefore, whilst the catalyst according to the present invention may be used for LO bleaching any suitable substrate, the preferred substrate is a laundry fabric. Bleaching may be carried out by simply leaving the substrate in contact with the medium for a sufficient period of time. Preferably, however, the aqueous medium on or containing the substrate is agitated. L5 A further advantage is that, by enabling a bleaching effect even after the textile has been treated, the benefits of bleaching can be prolonged on the textile. Furthermore, since a bleaching effect is conferred to the textile after 20 the treatment, the treatment itself, such as a laundry wash cycle, may for example be shortened. Moreover, since a bleaching effect is achieved by atmospheric oxygen after treatment of the textile, hydrogen peroxide or peroxy-based bleach systems can be omitted from the treatment substance. 25 The present invention also extends to a commercial package comprising a bleaching composition comprising a ligand or complex as defined below together with instructions for its use. 30 WO 01/16272 PCT/EP00/08144 -8 The present invention also extends to use of a ligand or complex as defined below in the manufacture of a bleaching composition, the bleaching composition substantially devoid of peroxygen bleach or a peroxy-based or peroxy-generating 5 bleach system. DETAILED DESCRIPTION OF THE INVENTION The catalyst may be used as a preformed complex of the ligand and a transition metal. Alternatively, the catalyst LO may be formed from the free ligand that complexes with a transition metal already present in the water or that complexes with a transition metal present in the substrate. The composition may also be formulated as a composition of the free ligand or a transition metal-substitutable metal L5 ligand complex, and a source of transition metal, whereby the complex is formed in situ in the medium. The ligand forms a complex with one or more transition metals, in the latter case for example as a dinuclear 20 complex. Suitable transition metals include for example: manganese in oxidation states II-V, iron II-V, copper I-III, cobalt I-III, titanium II-IV, tungsten IV-VI, vanadium II-V and molybdenum II-VI. 25 The ligand forms a complex of the general formula (Al): [MaLkXnlYm (Al) in which: 30 M represents a metal selected from Mn(II)-(III)-(IV) (V), Cu(I)-(II)-(III), Fe(II)-(III)-(IV)-(V), Co(I)-(II)- WO 01/16272 PCT/EPOO/08144 -9 (II ), i(I )-III -(I ),V(II)-(III)-(IV)-(V), Mo(II) (III)-(IV)-(V)-(VI) and W(IV)-(V)-(VI), preferably selected from Fe(II)-(III)-(IV)-(V); L represents a ligand as herein defined, or its 5 protonated or deprotonated analogue; X represents a coordinating species selected from any mono, bi or tri charged anions and any neutral molecules able to coordinate the metal in a mono, bi or tridentate manner, preferably selected from 02, RB0 2 2 -, RCOO, RCONR, 2- 3- 3- 2 L 0 OH~, N03~, NO, S -, RS-, P0 4 ~, PO 3 OR3-, H 2 0, C03 -, HCO3, ROH,

N(R)

3 , ROO~, 022-, 02-, RCN, Cl~, Br~, OCN~, SCN , CN~, N 3 ~, F-, I~, RO0, C104-, and CF 3 SO3 , and more preferably selected from 2- 2- 2- 4- 2 0 2, RB0 2 , RCOO, OH~, NO3, S -, RS, P0 3 ~, H 2 0, C03 -, HCO3, ROH, N(R) 3 , Cl~ , Br-, OCN , SCN, RCN, N 3 ~, F-, I~, RO0, C104~, L5 and CF 3 SO3 ; Y represents any non-coordinated counter ion, preferably selected from C104~, BR 4 ~ , [MX 4 ] , [MX 4

]

2 ~, PF6_, RCOO , N0 3 -, RO~, N*(R) 4 , ROO-, 022-, 02~, Cl~ , Br-, F-, I~,

CF

3 50 3 , S206 2- , OCN, SCN, H 2 0, RB02 2-, BF4 and BPh4 , and ?0 more preferably selected from C104-, BR4 , [FeCl 4 ] -, PF6 , RCOO , NO3, RO~, N*(R) 4 , Cl , Br~, F, I-, CF 3 SO3~, S20 6 2 OCN~, SCN, H 2 0 and BF4~; a represents an integer from 1 to 10, preferably from 1 to 4; 25 k represents an integer from 1 to 10; n represents an integer from 1 to 10, preferably from 1 to 4; m represents zero or an integer from 1 to 20, preferably from 1 to 8; and 30 each R independently represents a group selected from hydrogen, hydroxyl, -R' and -OR', wherein R'= alkyl, alkenyl, WO 01/16272 PCT/EPOO/08144 - 10 cycloalkyl, heterocycloalkyl, aryl, heteroaryl or a carbonyl derivative group, R' being optionally substituted by one or more functional groups E, wherein E independently represents a functional group selected from -F, -Cl, -Br, -I, -OH, -OR', 5 -NH 2 , -NHR', -N(R') 2 , -N(R') 3 *, -C(O)R', -OC(O)R', -COOH, -C00~ (Na+, K*) , -COOR', -C (0 )NH2, -C (O) NHR', -C (O) N (R') 2, heteroaryl, -R', -SR', -SH, -P(R') 2 , -P(O) (R') 2 , -P(O) (OH) 2 , P (0) (OR') 2, -NO 2 , -SO 3 H, -S0 3 ~ (Na*, K*) , -S (0) 2 R', -NHC (0) R', and -N (R') C (0) R', wherein R' represents cycloalkyl, aryl, 10 arylalkyl, or alkyl optionally substituted by -F, -Cl, -Br, -I, -NH3, -SO 3 H, -SO 3 -(Na+, K*), -COOH, -COOU(Na*, K+), P(0) (OH) 2 , or -P(0) (O~(Na*, K+)) 2 , and preferably each R independently represents hydrogen, optionally substituted alkyl or optionally substituted aryl, more preferably 15 hydrogen or optionally substituted phenyl, naphthyl or C1- 4 alkyl. The ligand L is of the general formula (I): R1 Qj- ,N',Q,,N Q2-R2 N

Q

3 R3 20 R 3 (I) wherein WO 01/16272 PCT/EPOO/08144 - 11 R 1 , R 2 , and R 3 independently represent a group selected from hydrogen, hydroxyl, halogen, -NH-C(NH)NH 2 , -R and -OR, wherein R= alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl or a carbonyl derivative group, R being 5 optionally substituted by one or more functional groups E; Q independently represent a group selected from C 2

-

3 alkylene optionally substituted by H, benzyl or Ci-B-alkyl; LO Qi, Q2 and Q3 independently represent a group of the formula: R5 R7

J

6 8 [5 wherein 5 > a+b+c > 1; a=0-5; b=0-5; c=0-5; n=l or 2; Y independently represents a group selected from -O-, 20 S-, -SO-, -SO 2 -, -C(0)-, arylene, alkylene, heteroarylene, heterocycloalkylene, -(G)P-, -P(O)- and -(G)N- , wherein G is selected from hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, each except hydrogen being optionally substituted by one or more functional groups E; and 25 WO 01/16272 PCT/EPOO/08144 - 12 R5, R6, R7, R8 independently represent a group selected from hydrogen, hydroxyl, halogen, -R and -OR, wherein R represents alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl or a carbonyl derivative group, R being 5 optionally substituted by one or more functional groups E, or R5 together with R6, or R7 together with R8, or both, represent oxygen, or R5 together with R7 and/or independently R6 together with R8, or R5 together with R8 and/or independently R6 0 together with R7, represent Ci- 6 -alkylene optionally substituted by Ci- 4 -alkyl, -F, -Cl, -Br or -I, provided that two of R 1 , R 2 and R 3 are coordinating groups and one of R 1 , R 2 and R 3 is a non-coordinating group, .5 and with the proviso that the following ligands are excluded: 1,4-bis(N-methyl-imidazol-2ylmethyl)-1,4,7 0 triazacyclononane; 1,4-bis(N-methyl-imidazol-2ylmethyl)-7-acetate-1,4,7 triazacyclononane; 1,4-bis(pyridin-2-ylmethyl)-7-ethyl-1,4,7-triazacyclononane; 1,4-bis(quinolin-2-ylmethyl)-7-ethyl-1,4,7 25 triazacyclononane; 1,4-bis(pyrazol-1-ylmethyl)-7-ethyl-1,4,7-triazacyclononane; 1,4-bis(3,5-dimethylpyrazol-1-ylmethyl)-7-ethyl-1,4,7 triazacyclononane; 1,4-bis(N-methylimidazol-2-ylmethyl)-7-ethyl-1,4,7 30 triazacyclononane; WO 01/16272 PCT/EPOO/08144 - 13 1,4-bis(2'-(aceto-N-isopropylamido))-7-ethyl-1,4,7 triazacyclononane; and 1,4-bis(2'-(aceto-N-methylamido))-7-ethyl-1,4,7 triazacyclononane. 5 Two of R 1 , R 2 and R 3 independently represent a group preferably selected from carboxylate, amido, -NH-C(NH)NH 2 , hydroxyphenyl, an optionally substituted heterocyclic ring or an optionally substituted heteroaromatic ring selected 10 from pyridine, pyrimidine, pyrazine, pyrazole, imidazole, benzimidazole, quinoline, quinoxaline, triazole, isoquinoline, carbazole, indole, isoindole, oxazole and thiazole. Preferably, two of R 1 , R 2 , R 3 each independently represent a coordinating group selected from optionally 15 substituted pyridin-2-yl, optionally substituted imidazol-2 yl, optionally substituted imidazol-4-yl, optionally substituted pyrazol-1-yl, and optionally substituted quinolin-2-yl. 20 Preferably, substituents for groups R 1 , R 2 , R 3 , when representing a heterocyclic or heteroaromatic ring, are selected from C 14 -alkyl, aryl, arylalkyl, heteroaryl, methoxy, hydroxy, nitro, amino, carboxyl, halo, and carbonyl. 25 The groups R5, R6, R7, R8 preferably independently represent a group selected from -H, hydroxy-Co-C 2 -alkyl, halo-Co-C 2 0 alkyl, nitroso, formyl-Co-C 20 -alkyl, carboxyl-Co-C 20 -alkyl and esters and salts thereof, carbamoyl-Co-C 20 -alkyl, sulfo-Co 30 C 20 -alkyl and esters and salts thereof, sulfamoyl-Co-C 20 alkyl, amino-Co-C 20 -alkyl, aryl-Co-C 20 -alkyl, Co-C 20 -alkyl, WO 01/16272 PCT/EPOO/08144 - 14 alkoxy-Co-C-alkyl, carbonyl-Co-C 6 -alkoxy, and Co-C 2 0 alkylamide. Preferably, none of R6-R8 is linked together. Preferably, Qi, Q2 and Q3 are defined such that a=b=0, 5 c=1,2,3 or 4 and n=1. Preferably, the groups Qi, Q2 and Q3 independently represent a group selected from -CH 2 - and CH 2

CH

2 -. Group Q is preferably a group selected from -CH 2

CH

2 - and LO CH 2

CH

2

CH

2 -. In a first preferred embodiment, the ligand L is of the general formula (II): Qg--R2 N R1-Q 1 15 R3 (II) wherein R1, R2, R3 are as defined previously for R 1 , R 2 , R 3 , and Qi, Q2, Q3 are as defined previously. 20 A preferred class of ligand according to the first preferred embodiment, as represented by formula (II) above, has ligands of the general formula (II) wherein: two of R1, R2, R3 each independently represent a coordinating group selected from carboxylate, amido, -NH 25 C(NH)NH 2 , hydroxyphenyl, an optionally substituted WO 01/16272 PCT/EPOO/08144 - 15 heterocyclic ring or an optionally substituted heteroaromatic ring selected from pyridine, pyrimidine, pyrazine, pyrazole, imidazole, benzimidazole, quinoline, quinoxaline, triazole, isoquinoline, carbazole, indole, 5 isoindole, oxazole and thiazole; and one of R1, R2, R3 represents a group selected from hydrogen, C1-20 optionally substituted alkyl, Cl20 optionally substituted arylalkyl, aryl, and C20 optionally substituted

NR

3 * (wherein R=Ci-B-alkyl). 10 In this class, we prefer that: two of Rl, R2, R3 each independently represent a coordinating group selected from optionally substituted pyridin-2-yl, optionally substituted imidazol-2-yl, 15 optionally substituted imidazol-4-yl, optionally substituted pyrazol-1-yl, and optionally substituted quinolin-2-yl; and one of R1, R2, R3 represents a group selected from hydrogen, Ci.1o optionally substituted alkyl, C 1 5 -furanyl, C15 optionally substituted benzylalkyl, benzyl, Ci-5 optionally 20 substituted alkoxy, and Cl120 optionally substituted N*Me 3 . A particularly preferred ligand is 1,4-bis(5-methyl-pyridin 2-ylmethyl)-7-ethyl-1,4,7-triazacyclononane. 25 The counter ions Y in formula (Al) balance the charge z on the complex formed by the ligand L, metal M and coordinating species X. Thus, if the charge z is positive, Y may be an anion such as RCOO, BPh4J, C104-, BF4~, PF6 , RS0 3 ~, RSO4~, SO 4 2 , N0 3 ~, F-, Cl , Br-, or I-, with R being hydrogen, 30 optionally substituted alkyl or optionally substituted aryl.

WO 01/16272 PCT/EPOO/08144 - 16 If z is negative, Y may be a common cation such as an alkali metal, alkaline earth metal or (alkyl)ammonium cation. Suitable counter ions Y include those which give rise to the 5 formation of storage-stable solids. Preferred counter ions for the preferred metal complexes are selected from R7COO~, C10 4 -, BF4~, PF6~, RS0 3 ~ (in particular CF 3 SO3~) , RSO4, S042 NO3, F~, Cl~, Br-, and I~, wherein R represents hydrogen or optionally substituted phenyl, naphthyl or Ci-C 4 alkyl. 10 It will be appreciated that the complex (Al) can be formed by any appropriate means, including in situ formation whereby precursors of the complex are transformed into the active complex of general formula (Al) under conditions of 15 storage or use. Preferably, the complex is formed as a well-defined complex or in a solvent mixture comprising a salt of the metal M and the ligand L or ligand L-generating species. Alternatively, the catalyst may be formed in situ from suitable precursors for the complex, for example in a 20 solution or dispersion containing the precursor materials. In one such example, the active catalyst may be formed in situ in a mixture comprising a salt of the metal M and the ligand L, or a ligand L-generating species, in a suitable solvent. Thus, for example, if M is iron, an iron salt such 25 as FeSO 4 can be mixed in solution with the ligand L, or a ligand L-generating species, to form the active complex. Thus, for example, the composition may formed from a mixture of the ligand L and a metal salt MX, in which preferably n=l 5, more preferably 1-3. In another such example, the ligand 30 L, or a ligand L-generating species, can be mixed with metal M ions present in the substrate or wash liquor to form the WO 01/16272 PCT/EPOO/08144 - 17 active catalyst in situ. Suitable ligand L-generating species include metal-free compounds or metal coordination complexes that comprise the ligand L and can be substituted by metal M ions to form the active complex according the 5 formula (Al). The catalysts according to the present invention may be used for laundry cleaning, hard surface cleaning (including cleaning of lavatories, kitchen work surfaces, floors, L0 mechanical ware washing etc.). As is generally known in the art, bleaching compositions are also employed in waste-water treatment, pulp bleaching during the manufacture of paper, leather manufacture, dye transfer inhibition, food processing, starch bleaching, sterilisation, whitening in L5 oral hygiene preparations and/or contact lens disinfection. In the context of the present invention, bleaching should be understood as relating generally to the decolourisation of stains or of other materials attached to or associated with 20 a substrate. However, it is envisaged that the present invention can be applied where a requirement is the removal and/or neutralisation by an oxidative bleaching reaction of malodours or other undesirable components attached to or otherwise associated with a substrate. Furthermore, in the 25 context of the present invention bleaching is to be understood as being restricted to any bleaching mechanism or process that does not require the presence of light or activation by light. 30 In typical washing compositions the level of the catalyst is such that the in-use level is from 0.05pM to 50mM, with WO 01/16272 PCT/EPOO/08144 - 18 preferred in-use levels for domestic laundry operations falling in the range 0.5 ptM to 100 tM, more preferably from 1 iM to 10 pM. Higher levels may be desired and applied in industrial bleaching processes, such as textile and paper 5 pulp bleaching. Preferably, the aqueous medium has a pH in the range from pH 6 to 13, more preferably from pH 6 to 11, still more preferably from pH 8 to 11, and most preferably from pH 8 to 10 10, in particular from pH 9 to 10. The bleaching catalyst of the present invention has particular application in detergent formulations, especially for laundry cleaning. The detergent bleach composition may 15 for example contain a surface-active material in an amount of from 10 to 50% by weight. The surface-active material may be naturally derived, such as soap, or a synthetic material selected from anionic, nonionic, amphoteric, zwitterionic, cationic actives and mixtures thereof. Many 20 suitable actives are commercially available and are fully described in the literature, for example in "Surface Active Agents and Detergents", Volumes I and II, by Schwartz, Perry and Berch. 25 Typical synthetic anionic surface-actives are usually water soluble alkali metal salts of organic sulfates and sulfonates having alkyl groups containing from about 8 to about 22 carbon atoms, the term "alkyl" being used to include the alkyl portion of higher aryl groups. Examples 30 of suitable synthetic anionic detergent compounds are sodium and ammonium alkyl sulfates, especially those obtained by WO 01/16272 PCT/EPOO/08144 - 19 sulfating higher (C 8

-C

18 ) alcohols produced, for example, from tallow or coconut oil; sodium and ammonium alkyl (C9 C20) benzene sulfonates, particularly sodium linear secondary alkyl (C 10

-C

15 ) benzene sulfonates; sodium alkyl glyceryl 5 ether sulfates, especially those ethers of the higher alcohols derived from tallow or coconut oil fatty acid monoglyceride sulfates and sulfonates; sodium and ammonium salts of sulfuric acid esters of higher (Cs-Ci8) fatty alcohol alkylene oxide, particularly ethylene oxide, 10 reaction products; the reaction products of fatty acids such as coconut fatty acids esterified with isethionic acid and neutralised with sodium hydroxide; sodium and ammonium salts of fatty acid amides of methyl taurine; alkane monosulfonates such as those derived by reacting alpha 15 olefins (C 8

-C

20 ) with sodium bisulfite and those derived by reacting paraffins with SO 2 and C1 2 and then hydrolysing with a base to produce a random sulfonate; sodium and ammonium

(C

7

-C

12 ) dialkyl sulfosuccinates; and olefin sulfonates, which term is used to describe material made by reacting 20 olefins, particularly (C 10

-C

20 ) alpha-olefins, with SO 3 and then neutralising and hydrolysing the reaction product. The preferred anionic detergent compounds are sodium (C 10

-C

1 3) alkylbenzene sulfonates, and sodium (C 16

-C

18 ) alkyl ether sulfates. 25 Examples of suitable nonionic surface-active compounds which may be used, preferably together with the anionic surface active compounds, include, in particular, the reaction products of alkylene oxides, usually ethylene oxide, with 30 alkyl (C 6

-C

2 2 ) phenols, generally 5-25 EO, i.e. 5-25 units of ethylene oxides per molecule; and the condensation products WO 01/16272 PCTEPOO/08144 - 20 of aliphatic (CB-C18) primary or secondary linear or branched alcohols with ethylene oxide, generally 2-30 EO. Other so called nonionic surface-actives include alkyl polyglycosides, sugar esters, long-chain tertiary amine 5 oxides, long-chain tertiary phosphine oxides and dialkyl sulfoxides. Amphoteric or zwitterionic surface-active compounds can also be used but this is not normally desired owing to their 10 relatively high cost. If any amphoteric or zwitterionic detergent compounds are used, it is generally in small amounts in compositions based on the much more commonly used synthetic anionic and nonionic actives. 15 The detergent bleach composition will preferably comprise from 1 to 15 % wt of anionic surfactant and from 10 to 40 % by weight of nonionic surfactant. In a further preferred embodiment, the detergent active system is free from C16-C12 fatty acid soaps. 20 The bleach composition may also contains a detergency builder, for example in an amount of from about 5 to 80 % by weight, preferably from about 10 to 60 % by weight. 25 Builder materials may be selected from 1) calcium sequestrant materials, 2) precipitating materials, 3) calcium ion-exchange materials and 4) mixtures thereof. Examples of calcium sequestrant builder materials include 30 alkali metal polyphosphates, such as sodium tripolyphosphate; nitrilotriacetic acid and its water- WO 01/16272 PCT/EPOO/08144 - 21 soluble salts; the alkali metal salts of carboxymethyloxy succinic acid, ethylene diamine tetraacetic acid, oxydisuccinic acid, mellitic acid, benzene polycarboxylic acids, citric acid; and polyacetal carboxylates as disclosed 5 in US-A-4,144,226 and US-A-4,146,495. Examples of precipitating builder materials include sodium orthophosphate and sodium carbonate. 10 Examples of calcium ion-exchange builder materials include the various types of water-insoluble crystalline or amorphous aluminosilicates, of which zeolites are the best known representatives, e.g. zeolite A, zeolite B (also known as zeolite P), zeolite C, zeolite X, zeolite Y and also the 15 zeolite P-type as described in EP-A-0,384,070. In particular, the compositions may contain any one of the organic and inorganic builder materials, though, for environmental reasons, phosphate builders are preferably 20 omitted or only used in very small amounts. Typical builders usable in the present invention are, for example, sodium carbonate, calcite/carbonate, the sodium salt of nitrilotriacetic acid, sodium citrate, carboxymethyloxy malonate, carboxymethyloxy succinate and water-insoluble 25 crystalline or amorphous aluminosilicate builder materials, each of which can be used as the main builder, either alone or in admixture with minor amounts of other builders or polymers as co-builder. 30 It is preferred that the composition contains not more than 5% by weight of a carbonate builder, expressed as sodium WO 01/16272 PCT/EPOO/08144 - 22 carbonate, more preferably not more than 2.5 % by weight to substantially nil, if the composition pH lies in the lower alkaline region of up to 10. 5 Apart from the components already mentioned, the bleach composition can contain any of the conventional additives in amounts of which such materials are normally employed in fabric washing detergent compositions. Examples of these additives include buffers such as carbonates, lather .0 boosters, such as alkanolamides, particularly the monoethanol amides derived from palmkernel fatty acids and coconut fatty acids; lather depressants, such as alkyl phosphates and silicones; anti-redeposition agents, such as sodium carboxymethyl cellulose and alkyl or substituted L5 alkyl cellulose ethers; stabilisers, such as phosphonic acid derivatives (i.e. Dequest@ types); fabric softening agents; inorganic salts and alkaline buffering agents, such as sodium sulfate and sodium silicate; and, usually in very small amounts, fluorescent agents; perfumes; enzymes, such 20 as proteases, cellulases, lipases, amylases and oxidases; germicides and colourants. Transition metal sequestrants such as EDTA, and phosphonic acid derivatives such as EDTMP (ethylene diamine 25 tetra(methylene phosphonate)) may also be included, in addition to the ligand specified, for example to improve the stability sensitive ingredients such as enzymes, fluorescent agents and perfumes, but provided the composition remains bleaching effective. However, the composition is preferably 30 substantially, and more preferably completely, devoid of transition metal sequestrants (other than the ligand).

WO 01/16272 PCT/EPOO/08144 - 23 Whilst the present invention is based on the catalytic bleaching of a substrate by atmospheric oxygen or air, it will be appreciated that small amounts of hydrogen peroxide or peroxy-based or -generating systems may be included in 5 the composition, if desired. Therefore, by "substantially devoid of peroxygen bleach or peroxy-based or -generating bleach systems" is meant that the composition contains from 0 to 50 %, preferably from 0 to 10 %, more preferably from 0 to 5 %, and optimally from 0 to 2 % by molar weight on an LO oxygen basis, of peroxygen bleach or peroxy-based or generating bleach systems. Preferably, however, the composition will be wholly devoid of peroxygen bleach or peroxy-based or -generating bleach systems. L5 Thus, at least 10 %, preferably at least 50 % and optimally at least 90 % of any bleaching of the substrate is effected by oxygen sourced from the air. Throughout the description and claims generic groups have 20 been used, for example alkyl, alkoxy, aryl. Unless otherwise specified the following are preferred group restrictions that may be applied to generic groups found within compounds disclosed herein: 25 alkyl: linear and branched Cl-C8-alkyl, alkenyl: C2-C6-alkenyl, cycloalkyl: C3-C8-cycloalkyl, 30 alkoxy: Cl-C6-alkoxy, WO 01/16272 PCT/EPOO/08144 - 24 alkylene: selected from the group consisting of: methylene; 1,1-ethylene; 1,2-ethylene; 1,1-propylidene; 1,2-propylene; 1,3-propylene; 2,2-propylidene; butan-2-ol-1,4-diyl; propan 5 2-ol-1,3-diyl; 1,4-butylene; cyclohexane-1,1-diyl; cyclohexan-1,2-diyl; cyclohexan-1,3-diyl; cyclohexan-1,4 diyl; cyclopentane-1,1-diyl; cyclopentan-1,2-diyl; and cyclopentan-1,3-diyl, 0 aryl: selected from homoaromatic compounds having a molecular weight under 300, arylene: selected from the group consisting of: 1,2 phenylene; 1,3-phenylene; 1,4-phenylene; 1,2-naphtalenylene; L5 1,3-naphtalenylene; 1,4-naphtalenylene; 2,3-naphtalenylene; 1-hydroxy-2,3-phenylene; 1-hydroxy-2,4-phenylene; 1-hydroxy 2,5-phenylene; and 1-hydroxy-2,6-phenylene, heteroaryl: selected from the group consisting of: 20 pyridinyl; pyrimidinyl; pyrazinyl; triazolyl; pyridazinyl; 1,3,5-triazinyl; quinolinyl; isoquinolinyl; quinoxalinyl; imidazolyl; pyrazolyl; benzimidazolyl; thiazolyl; oxazolidinyl; pyrrolyl; carbazolyl; indolyl; and isoindolyl, wherein the heteroaryl may be connected to the compound via 25 any atom in the ring of the selected heteroaryl, heteroarylene: selected from the group consisting of: pyridindiyl; quinolindiyl; pyrazodiyl; pyrazoldiyl; triazolediyl; pyrazindiyl; and imidazolediyl, wherein the 30 heteroarylene acts as a bridge in the compound via any atom in the ring of the selected heteroarylene, more specifically WO 01/16272 PCT/EPOO/08144 - 25 preferred are: pyridin-2,3-diyl; pyridin-2,4-diyl; pyridin 2,5-diyl; pyridin-2,6-diyl; pyridin-3,4-diyl; pyridin-3,5 diyl; quinolin-2,3-diyl; quinolin-2,4-diyl; quinolin-2,8 diyl; isoquinolin-1,3-diyl; isoquinolin-1,4-diyl; pyrazol 5 1,3-diyl; pyrazol-3,5-diyl; triazole-3,5-diyl; triazole-1,3 diyl; pyrazin-2,5-diyl; and imidazole-2,4-diyl, heterocycloalkyl: selected from the group consisting of: pyrrolinyl; pyrrolidinyl; morpholinyl; piperidinyl; 10 piperazinyl; hexamethylene imine; 1,4-piperazinyl; tetrahydrothiophenyl; tetrahydrofuranyl; 1,4,7 triazacyclononanyl; 1,4,8,11-tetraazacyclotetradecanyl; 1,4,7,10,13-pentaazacyclopentadecanyl; 1,4-diaza-7-thia cyclononanyl; 1,4-diaza-7-oxa-cyclononanyl; 1,4,7,10 15 tetraazacyclododecanyl; 1,4-dioxanyl; 1,4,7-trithia cyclononanyl; tetrahydropyranyl; and oxazolidinyl, wherein the heterocycloalkyl may be connected to the compound via any atom in the ring of the selected heterocycloalkyl, 20 heterocycloalkylene: selected from the group consisting of: piperidin-1,2-ylene; piperidin-2,6-ylene; piperidin-4,4 ylidene; 1,4-piperazin-1,4-ylene; 1,4-piperazin-2,3-ylene; 1,4-piperazin-2,5-ylene; 1,4-piperazin-2,6-ylene; 1,4 piperazin-1,2-ylene; 1,4-piperazin-1,3-ylene; 1,4-piperazin 25 1,4-ylene; tetrahydrothiophen-2,5-ylene; tetrahydrothiophen 3,4-ylene; tetrahydrothiophen-2,3-ylene; tetrahydrofuran 2,5-ylene; tetrahydrofuran-3,4-ylene; tetrahydrofuran-2,3 ylene; pyrrolidin-2,5-ylene; pyrrolidin-3,4-ylene; pyrrolidin-2,3-ylene; pyrrolidin-1,2-ylene; pyrrolidin-1,3 30 ylene; pyrrolidin-2,2-ylidene; 1,4,7-triazacyclonon-1,4 ylene; 1,4,7-triazacyclonon-2,3-ylene; 1,4,7-triazacyclonon- WO 01/16272 PCT/EPOO/08144 - 26 2,9-ylene; 1,4,7-triazacyclonon-3,8-ylene; 1,4,7 triazacyclonon-2,2-ylidene; 1,4,8,11-tetraazacyclotetradec 1,4-ylene; 1,4,8,11-tetraazacyclotetradec-1,8-ylene; 1,4,8,11-tetraazacyclotetradec-2,3-ylene; 1,4,8,11 5 tetraazacyclotetradec-2,5-ylene; 1,4,8,11 tetraazacyclotetradec-1,2-ylene; 1,4,8,11 tetraazacyclotetradec-2,2-ylidene; 1,4,7,10 tetraazacyclododec-1,4-ylene; 1,4,7,10-tetraazacyclododec 1,7-ylene; 1,4,7,10-tetraazacyclododec-1,2-ylene; 1,4,7,10 10 tetraazacyclododec-2,3-ylene; 1,4,7,10-tetraazacyclododec 2,2-ylidene; 1,4,7,10,13-pentaazacyclopentadec-1,4-ylene; 1,4,7,10,13-pentaazacyclopentadec-1,7-ylene; 1,4,7,10,13 pentaazacyclopentadec-2,3-ylene; 1,4,7,10,13 pentaazacyclopentadec-1,2-ylene; 1,4,7,10,13 15 pentaazacyclopentadec-2,2-ylidene; 1,4-diaza-7-thia cyclonon-1,4-ylene; 1,4-diaza-7-thia-cyclonon-1,2-ylene; 1,4-diaza-7-thia-cyclonon-2,3-ylene; 1,4-diaza-7-thia cyclonon-6,8-ylene; 1,4-diaza-7-thia-cyclonon-2,2-ylidene; 1,4-diaza-7-oxa-cyclonon-1,4-ylene; 1,4-diaza-7-oxa 20 cyclonon-1,2-ylene; 1,4-diaza-7-oxa-cyclonon-2,3-ylene; 1,4 diaza-7-oxa-cyclonon-6,8-ylene; 1,4-diaza-7-oxa-cyclonon 2,2-ylidene; 1,4-dioxan-2,3-ylene; 1,4-dioxan-2,6-ylene; 1,4-dioxan-2,2-ylidene; tetrahydropyran-2,3-ylene; tetrahydropyran-2,6-ylene; tetrahydropyran-2,5-ylene; 25 tetrahydropyran-2,2-ylidene; 1,4,7-trithia-cyclonon-2,3 ylene; 1,4,7-trithia-cyclonon-2,9-ylene; and 1,4,7-trithia cyclonon-2,2-ylidene, amine: the group -N(R) 2 wherein each R is independently 30 selected from: hydrogen; Cl-C6-alkyl; C1-C6-alkyl-C6H5; and phenyl, wherein when both R are Cl-C6-alkyl both R together WO 01/16272 PCT/EPOO/08144 - 27 may form an -NC3 to an -NC5 heterocyclic ring with any remaining alkyl chain forming an alkyl substituent to the heterocyclic ring, 5 halogen: selected from the group consisting of: F; Cl; Br and I, sulfonate: the group -S(0) 2 0R, wherein R is selected from: hydrogen; C1-C6-alkyl; phenyl; C1-C6-alkyl-C6H5; Li; 10 Na; K; Cs; Mg; and Ca, sulfate: the group -OS(0) 2 0R, wherein R is selected from: hydrogen; C1-C6-alkyl; phenyl; C1-C6-alkyl-C6H5; Li; Na; K; Cs; Mg; and Ca, 15 sulfone: the group -S(0) 2 R, wherein R is selected from: hydrogen; C1-C6-alkyl; phenyl; C1-C6-alkyl-C6H5 and amine (to give sulfonamide) selected from the group: -NR'2, wherein each R' is independently selected from: hydrogen; 20 C1-C6-alkyl; C1-C6-alkyl-C6H5; and phenyl, wherein when both R' are C1-C6-alkyl both R' together may form an -NC3 to an NC5 heterocyclic ring with any remaining alkyl chain forming an alkyl substituent to the heterocyclic ring, 25 carboxylate derivative: the group -C(O)OR, wherein R is selected from: hydrogen; C1-C6-alkyl; phenyl; C1-C6-alkyl C6H5; Li; Na; K; Cs; Mg; and Ca, carbonyl derivative: the group -C(O)R, wherein R is 30 selected from: hydrogen; C1-C6-alkyl; phenyl; Cl-C6-alkyl C6H5 and amine (to give amide) selected from the group: - WO 01/16272 PCT/EPOO/08144 - 28 NR'2, wherein each R' is independently selected from: hydrogen; Cl-C6-alkyl; Cl-C6-alkyl-C6H5; and phenyl, wherein when both R' are Cl-C6-alkyl both R' together may form an NC3 to an -NC5 heterocyclic ring with any remaining alkyl 5 chain forming an alkyl substituent to the heterocyclic ring, phosphonate: the group -P(0) (OR) 2 , wherein each R is independently selected from: hydrogen; Cl-C6-alkyl; phenyl; C1-C6-alkyl-C6H5; Li; Na; K; Cs; Mg; and Ca, 10 phosphate: the group -OP(O) (OR) 2 , wherein each R is independently selected from: hydrogen; Cl-C6-alkyl; phenyl; C1-C6-alkyl-C6H5; Li; Na; K; Cs; Mg; and Ca, 15 phosphine: the group -P(R) 2 , wherein each R is independently selected from: hydrogen; Cl-C6-alkyl; phenyl; and Cl-C6-alkyl-C6H5, phosphine oxide: the group -P(0)R 2 , wherein R is 20 independently selected from: hydrogen; Cl-C6-alkyl; phenyl; and Cl-C6-alkyl-C6H5; and amine (to give phosphonamidate) selected from the group: -NR'2, wherein each R' is independently selected from: hydrogen; Cl-C6-alkyl; C1-C6 alkyl-C6H5; and phenyl, wherein when both R' are Cl-C6-alkyl 25 both R' together may form an -NC3 to an -NC5 heterocyclic ring with any remaining alkyl chain forming an alkyl substituent to the heterocyclic ring. Unless otherwise specified the following are more preferred 30 group restrictions that may be applied to groups found within compounds disclosed herein: WO 01/16272 PCT/EPOO/08144 - 29 alkyl: linear and branched C1-C6-alkyl, alkenyl: C3-C6-alkenyl, 5 cycloalkyl: C6-C8-cycloalkyl, alkoxy: C1-C4-alkoxy, LO alkylene: selected from the group consisting of: methylene; 1,2-ethylene; 1,3-propylene; butan-2-ol-1,4-diyl; 1,4 butylene; cyclohexane-1,1-diyl; cyclohexan-1,2-diyl; cyclohexan-1,4-diyl; cyclopentane-1,1-diyl; and cyclopentan 1,2-diyl, L5 aryl: selected from group consisting of: phenyl; biphenyl; naphthalenyl; anthracenyl; and phenanthrenyl, arylene: selected from the group consisting of: 1,2 20 phenylene; 1,3-phenylene; 1,4-phenylene; 1,2-naphtalenylene; 1,4-naphtalenylene; 2,3-naphtalenylene and 1-hydroxy-2,6 phenylene, heteroaryl: selected from the group consisting of: 25 pyridinyl; pyrimidinyl; quinolinyl; pyrazolyl; triazolyl; isoquinolinyl; imidazolyl; and oxazolidinyl, wherein the heteroaryl may be connected to the compound via any atom in the ring of the selected heteroaryl, 30 heteroarylene: selected from the group consisting of: pyridin-2,3-diyl; pyridin-2,4-diyl; pyridin-2,6-diyl; WO 01/16272 PCT/EPOO/08144 - 30 pyridin-3,5-diyl; quinolin-2,3-diyl; quinolin-2,4-diyl; isoquinolin-1,3-diyl; isoquinolin-1,4-diyl; pyrazol-3,5 diyl; and imidazole-2,4-diyl, 5 heterocycloalkyl: selected from the group consisting of: pyrrolidinyl; morpholinyl; piperidinyl; piperidinyl; 1,4 piperazinyl; tetrahydrofuranyl; 1,4,7-triazacyclononanyl; 1,4,8,11-tetraazacyclotetradecanyl; 1,4,7,10,13 pentaazacyclopentadecanyl; 1,4,7,10-tetraazacyclododecanyl; 10 and piperazinyl, wherein the heterocycloalkyl may be connected to the compound via any atom in the ring of the selected heterocycloalkyl, heterocycloalkylene: selected from the group consisting 15 of: piperidin-2,6-ylene; piperidin-4,4-ylidene; 1,4 piperazin-1,4-ylene; 1,4-piperazin-2,3-ylene; 1,4-piperazin 2,6-ylene; tetrahydrothiophen-2,5-ylene; tetrahydrothiophen 3,4-ylene; tetrahydrofuran-2,5-ylene; tetrahydrofuran-3,4 ylene; pyrrolidin-2,5-ylene; pyrrolidin-2,2-ylidene; 1,4,7 20 triazacyclonon-1,4-ylene; 1,4,7-triazacyclonon-2,3-ylene; 1,4,7-triazacyclonon-2,2-ylidene; 1,4,8,11 tetraazacyclotetradec-1,4-ylene; 1,4,8,11 tetraazacyclotetradec-1,8-ylene; 1,4,8,11-tetraazacyclotetradec-2,3-ylene; 1,4,8,11 25 tetraazacyclotetradec-2,2-ylidene; 1,4,7,10-tetraazacyclododec-1,4-ylene; 1,4,7,10 tetraazacyclododec-1,7-ylene; 1,4,7,10-tetraazacyclododec-2,3-ylene; 1,4,7,10 tetraazacyclododec-2,2-ylidene; 1,4,7,10,13 30 pentaazacyclopentadec-1,4-ylene; 1,4,7,10,13 pentaazacyclopentadec-1,7-ylene; 1,4-diaza-7-thia-cyclonon- WO 01/16272 PCT/EPOO/08144 - 31 1,4-ylene; 1,4-diaza-7-thia-cyclonon-2,3-ylene; 1,4-diaza-7 thia-cyclonon-2,2-ylidene; 1,4-diaza-7-oxa-cyclonon-1,4 ylene; 1,4-diaza-7-oxa-cyclonon-2,3-ylene;1,4-diaza-7-oxa cyclonon-2,2-ylidene; 1,4-dioxan-2,6-ylene; 1,4-dioxan-2,2 5 ylidene; tetrahydropyran-2,6-ylene; tetrahydropyran-2,5 ylene; and tetrahydropyran-2,2-ylidene, amine: the group -N(R) 2 , wherein each R is independently selected from: hydrogen; Cl-C6-alkyl; and benzyl, 10 halogen: selected from the group consisting of: F and Cl, sulfonate: the group -S(0) 2 0R, wherein R is selected from: hydrogen; Cl-C6-alkyl; Na; K; Mg; and Ca, 15 sulfate: the group -OS(0) 2 0R, wherein R is selected from: hydrogen; Cl-C6-alkyl; Na; K; Mg; and Ca, sulfone: the group -S(0) 2 R, wherein R is selected from: 20 hydrogen; Cl-C6-alkyl; benzyl and amine selected from the group: -NR'2, wherein each R' is independently selected from: hydrogen; Cl-C6-alkyl; and benzyl, carboxylate derivative: the group -C(O)OR, wherein R is 25 selected from hydrogen; Na; K; Mg; Ca; Cl-C6-alkyl; and benzyl, carbonyl derivative: the group: -C(O)R, wherein R is selected from: hydrogen; Cl-C6-alkyl; benzyl and amine 30 selected from the group: -NR'2, wherein each R' is WO 01/16272 PCT/EPOO/08144 - 32 independently selected from: hydrogen; Cl-C6-alkyl; and benzyl, phosphonate: the group -P(0) (OR) 2 , wherein each R is 5 independently selected from: hydrogen; Cl-C6-alkyl; benzyl; Na; K; Mg; and Ca, phosphate: the group -OP(0) (OR) 2 , wherein each R is independently selected from: hydrogen; Cl-C6-alkyl; benzyl; L0 Na; K; Mg; and Ca, phosphine: the group -P(R) 2 , wherein each R is independently selected from: hydrogen; Cl-C6-alkyl; and benzyl, L5 phosphine oxide: the group -P(O)R 2 , wherein R is independently selected from: hydrogen; Cl-C6-alkyl; benzyl and amine selected from the group: -NR'2, wherein each R' is independently selected from: hydrogen; Cl-C6-alkyl; and 20 benzyl. The invention will now be further illustrated by way of the following non-limiting examples: 25 EXAMPLES The following compound was prepared: Compound 1: [FeL 4 Cl] (C10 4

)

2 30 L' = 1,4-bis(5-methyl-pyridin-2-ylmethyl)-7-ethyl-1,4,7 triazacyclononane WO 01/16272 PCT/EPOO/08144 - 33 Synthesis of ligand Ll: 1,4-bis(5-methyl-pyridyl-2-methyl) 7-ethyl-1,4,7-triazacyclononane 1,4,7-triazacyclononane 5 Ligand 1,4,7-triazacyclononane was produced according the modified method used by the team of Prof. Wieghardt . In this method the detosylation of the 1,4,7-tris-p toluenesulfon-1,4,7-triazacylononanamide is performed in 5 minutes in hot sulphuric acid of 1800C. Once the solution 10 has cooled down it is transferred into ether under vigorous stirring. The solution that surfaces is decanted and the residue is dissolved in some boiling water. At boiling temperature drops of concentrated hydrochloric acid are added. The brown crystals that precipitate are drained off 15 and washed with cold hydrochloric acid and then with ethanol and ether. The 1,4,7-triazacyclononane. trihydrochloride thus produced is then processed further as described by Wieghardt et al (K. Wieghardt et al, Chem Ber., 112, 2200 (1979)). 20 1,4,7-triazatricyclo[5.2.1. 0 410 ]decane (orthoamide) 0.5 mol 1,4,7-triazacyclononane, 64.3 g, 0.54 mol orthoformicacidtriethylester, 74.8 g, and 20 mmol p toluolsulphonacid, 4 g, are heated to 1500C. The ethanol 25 that is created and some of the esters are distilled off. After the reaction has been completed the orthoamide can be distilled off at a-pressure of <80 mbar in the form of a bright yellow volatile oil (b.p. 350 K at 133 Pa), in agreement with literature (T.J. Atkins, J. Am. Chem. Soc., 30 102, 6365 (1980)).

WO 01/16272 PCT/EPOO/08144 - 34 1-ethyl-1,4,7-triazacyclononan (Et-tacn) Into a mixture of 0.1 mol orthoamide, 13.92 g, dissolved in dry THF, slowly 0.1 mol ethylbromide, 10.9 g, is dripped. The suspension is stirred for 2 days at room temperature in 5 a closed flask. The microcrystalline powder is drained off and washed with some dry THF. The resulting bromide salt is very hygroscopic. The salt is dissolved in 80 ml water and boiled for 4 hours under back-flow. Then 16 g sodium hydroxide dissolved in 20 ml water is added. This creates a 10 4 molar reaction mixture. Immediately, a bright yellow oil is separated. To complete the reaction, boiling is continued for another 20 hours. After cooling down 300 ml toluol is added and the water is distilled off by means of a water separator. The reaction mixture is filtered and the toluol 15 is drained off by a rotary evaporator. The remaining product is a bright yellow oil. Yield: 13.8 g (89%). 1 H-NMR (CDCl 3 270 MHz; 300K): 2.59-2.39 (m; 14H); 1.83 (s, 2H); 0.90 ppm (t; 3H); 13 C-NMR: 52.1; 50.7; 46.5; 46.4; 12.4 ppm. 20 2-hydroxymethyl-5-methyl pyridine 2-Acetoxymethyl-5-methyl pyridine (30 g, 182 mmol) was dissolved in hydrochloric acid (100 mL, 4 N). The mixture was heated under reflux, until TLC (silica gel; triethylamine:ethyl acetate:petroleum ether 40-60 = 1:9:19) 25 showed complete absence of the acetate (normally 1 hour). The mixture was cooled, brought to pH > 11, extracted with dichloromethane (3 x 50 mL) and the solvent removed in vacuo. Pure 2-hydroxymethyl-5-methyl pyridine (18.80 g, 152 mmol, 84 %) was obtained by Kugelrohr distillation (p = 20 30 mm Hg, T = 130 1C) as a slightly yellow oil.

WO 01/16272 PCT/EPOO/08144 - 35 H NMR: 8 8.39 (s, 1H), 7.50 (dd, J = 7.8, J = 1.8, 1H), 7.15 (d, J = 8.1, 1H), 4.73 (s, 2H), 3.83 (br s, 1H), 2.34 (s, 3H); 1C NMR: 8 156.67, 148.66, 137.32, 131.62, 120.24, 64.12, 17.98. 5 1,4-bis(5-methyl-pyridyl-2-methyl)-7-ethyl-1,4,7 triazacyclononane 2-hydroxymethyl-5-methyl pyridine (2.70 g, 21.9 mmol) was dissolved in dichloromethane (25 mL). Thionyl chloride (25 10 mL) was added dropwise under cooling (ice bath). The resulting mixture was stirred for 1 hour and the solvents removed in vacuo (rotavap, until p = 20 mm Hg, T + 35*C). The remaining oil was used directly in the synthesis of the ligands, since it was known from the literature that the 15 free picolyl chlorides are somewhat unstable and are highly lachrymatory. To the resultant mixture was added dichloromethane (25 mL) and 1.55 g Et-tacn (10 mmol) was added. Under cooling with ice 8.0 g NaOH is added in portions over a period of 5 days in such a way that the pH 20 value remains below 9 and the temperature does not exceed 0*C. The solution gradually becomes red to brown. The solution is put in the refrigerator for one day. Any organic phase that has formed is separated. The watery phase is extracted by repeated shaking with chloroform. The combined 25 organic phases are dried over CaO. The chloroform is rotated off and a thick, mostly red-brown oil remains. This oil is still contaminated by traces of picolylchloride and by products of the alkaline hydrolysis of the picolylchlorides (approx. 5%). 30

Claims (12)

1. A ligand of the general formula (I): R1 Q1- N Q N ,Q2-R2 I I Q" N R3 Q 5 (I) wherein R 1 , R 2 , and R 3 independently represent a group selected 10 from hydrogen, hydroxyl, halogen, -NH-C(NH)NH 2 , -R and -OR, wherein R= alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl or a carbonyl derivative group, R being optionally substituted by one or more functional groups E; 15 Q independently represent a group selected from C2-3 alkylene optionally substituted by H, benzyl or Ci- 8 -alkyl; Qi, Q2 and Q3 independently represent a group of the formula: 20 WO 01/16272 PCT/EPOO/08144 - 37 R5 R7 R6 18 wherein 5 5 > a+b+c > 1; a=0-5; b=0-5; c=0-5; n=l or 2; Y independently represents a group selected from -o-, S-, -SO-, -SO2-, -C(O)-, arylene, alkylene, heteroarylene, heterocycloalkylene, -(G)P-, -P(0)- and -(G)N- , wherein G 10 is selected from hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, each except hydrogen being optionally substituted by one or more functional groups E; R5, R6, R7, R8 independently represent a group selected 15 from hydrogen, hydroxyl, halogen, -R and -OR, wherein R represents alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl or a carbonyl derivative group, R being optionally substituted by one or more functional groups E, or R5 together with R6, or R7 together with R8, or 20 both, represent oxygen, or R5 together with R7 and/or independently R6 together with R8, or R5 together with R8 and/or independently R6 together with R7, represent C 1 - 6 -alkylene optionally substituted by Ci 4 -alkyl, -F, -Cl, -Br or -I; and 25 WO 01/16272 PCT/EPOO/08144 - 38 E independently represents a functional group selected from -F, -Cl, -Br, -I, -OH, -OR', -NH 2 , -NHR', -N(R') 2 , N (R') 3*, -C (0) R', -OC (O) R', -COOH, -COO~ (Na*, K+) , -COOR', C(0)NH 2 , -C(0)NHR', -C(O)N(R') 2 , heteroaryl, -R', -SR', -SH, 5 P (R') 2, -P (0) (R') 2, -P (0) (OH) 2, -P (0) (OR') 2, -NO 2 , -SO 3 H, -S0 3 (Nat, K+) , -S (0) 2 R', -NHC (0) R', and -N (R') C (0) R', wherein R' represents cycloalkyl, aryl, arylalkyl, or alkyl optionally substituted by -F, -Cl, -Br, -I, -NH 3 *, -SO 3 H, -SC 3 ~(Na*, K+), -COOH, -COO~ (Na*, K+), -P (0) (OH) 2, or -P (0) (0 (Na*, K+) ) 2, 10 provided that two of R 1 , R 2 and R 3 are coordinating groups and one of R 1 , R 2 and R 3 is a non-coordinating group, and 15 with the proviso that the following ligands are excluded: 1,4-bis(N-methyl-imidazol-2ylmethyl)-1,4,7 triazacyclononane; 1,4-bis(N-methyl-imidazol-2ylmethyl)-7-acetate-1,4,7 20 triazacyclononane; 1,4-bis(pyridin-2-ylmethyl)-7-ethyl-1,4,7-triazacyclononane; 1,4-bis(quinolin-2-ylmethyl)-7-ethyl-1,4,7 triazacyclononane; 1,4-bis(pyrazol-1-ylmethyl)-7-ethyl-1,4,7-triazacyclononane; 25 1,4-bis(3,5-dimethylpyrazol-1-ylmethyl)-7-ethyl-1,4, 7 triazacyclononane; 1,4-bis(N-methylimidazol-2-ylmethyl)-7-ethyl-1,4,7 triazacyclononane; 1,4-bis(N-isopropylacetamido)-7-ethyl-1,4,7 30 triazacyclononane; and WO 01/16272 PCT/EPOO/08144 - 39 1,4-bis(N-methylacetamido)-7-ethyl-1,4,7-triazacyclononane.

2. A ligand according to claim 1, wherein two of R 1 , R 2 and R 3 independently represent a coordinating group selected from 5 carboxylate, amido, -NH-C(NH)NH 2 , hydroxyphenyl, an optionally substituted heterocyclic ring or an optionally substituted heteroaromatic ring selected from pyridine, pyrimidine, pyrazine, pyrazole, imidazole, benzimidazole, quinoline, quinoxaline, triazole, isoquinoline, carbazole, 10 indole, isoindole, oxazole and thiazole.

3. A ligand according to any preceding claim, wherein two of R1, R 2 , R 3 each independently represent a coordinating group selected from optionally substituted pyridin-2-yl, 15 optionally substituted imidazol-2-yl, optionally substituted imidazol-4-yl, optionally substituted pyrazol-1-yl, and optionally substituted quinolin-2-yl.

4. A ligand according to any preceding claim, wherein R5, 20 R6, R7, R8 independently represent a group selected from -H, hydroxy-Co-C 2 -alkyl, halo-Co-C 20 -alkyl, nitroso, formyl-Co C 2 -alkyl, carboxyl-Co-C 2 0 -alkyl and esters and salts thereof, carbamoyl-Co-C 20 -alkyl, sulfo-CO-C 2 0 -alkyl and esters and salts thereof, sulfamoyl-Co-C 20 -alkyl, amino-Co-C 20 -alkyl, 25 aryl-Co-C 2 -alkyl, Co-C 20 -alkyl, alkoxy-Co-C 8 -alkyl, carbonyl Co-C-alkoxy, and Co-C 2 0 -alkylamide.

5. A ligand according to any preceding claim, wherein Qi, Q2 and Q3 are defined such that a=b=0, c=1,2,3 or 4 and n=1. 30 WO 01/16272 PCT/EPOO/08144 - 40

6. A ligand according to any preceding claim, wherein Qi, Q2 and Q3 independently represent a group selected from -CH 2 and -CH 2 CH 2 - . 5

7. A ligand according to any preceding claim, wherein Q represents a group selected from -CH 2 CH 2 - and -CH 2 CH 2 CH 2 -

8. A ligand according to any preceding claim, wherein the ligand L is of the general formula (II): 10 Qj--R2 N R1--Q N \" N- 3 R3 (II)

9. A ligand according to claim 8, wherein 15 two of R1, R2, R3 each independently represent a coordinating group selected from carboxylate, amido, -NH C(NH)NH 2 , hydroxyphenol, an optionally substituted heterocyclic ring or an optionally substituted heteroaromatic ring selected from pyridine, pyrimidine, 20 pyrazine, pyrazole, imidazole, benzimidazole, quinoline, quinoxaline, triazole, isoquinoline, carbazole, indole, isoindole, oxazole and thiazole; and one of R1, R2, R3 represents a group selected from hydrogen, Cl- 2 0 optionally substituted alkyl, C 1 - 2 0 optionally WO 01/16272 PCT/EPOO/08144 - 41 substituted arylalkyl, aryl, and C1-20 optionally substituted NR 3 t (wherein R=Ci- 8 -alkyl) .

10. A ligand according to claim 9, wherein 5 two of R1, R2, R3 each independently represent a coordinating group selected from optionally substituted pyridin-2-yl, optionally substituted imidazol-2-yl, optionally substituted imidazol-4-yl, optionally substituted pyrazol-1-yl, and optionally substituted quinolin-2-yl; and 10 one of R1, R2, R3 represents a group selected from hydrogen, C1-10 optionally substituted alkyl, Ci- 5 -furanyl, Ci-5 optionally substituted benzylalkyl, benzyl, C-5 optionally substituted alkoxy, and C1-20 optionally substituted N*Me 3 . 15

11. A complex of a ligand and a transition metal, wherein the complex is of the general formula (Al): [MaLkXnlYm (Al) 20 in which: M represents a metal selected from Mn(II)-(III)-(IV) (V), Cu(I)-(II)-(III), Fe(II)-(III)-(IV)-(V), Co(I)-(II) (III), Ti(II)-(III)-(IV), V(II)-(III)-(IV)-(V), Mo(II) (III)-(IV)-(V)-(VI) and W(IV)-(V)-(VI); 25 X represents a coordinating species selected from any mono, bi or tri charged anions and any neutral molecules able to coordinate the metal in a mono, bi or tridentate manner; Y represents any non-coordinated counter ion; 30 a represents an integer from 1 to 10; k represents an integer from 1 to 10; WO 01/16272 PCT/EPOO/08144 - 42 n represents an integer from 1 to 10; m represents zero or an integer from 1 to 20; and L represents a ligand as defined in any of the preceding claims, or its protonated or deprotonated 5 analogue.

12. A complex according to claim 11, wherein: M represents Fe(II)-(III)-(IV)-(V); X represents a coordinating species selected from 02-, 10 RBO 2 -, RCOO , OH-, NO3, S -, RS-, P0 3 -, H 2 0, C03 2-, HC0 3 ~, ROH, N(R) 3 , Cl~ , Br-, OCN , SCN , RCN, N 3 -, F-, I~, RO~, C104~, and CF 3 SO3~; Y represents any non-coordinated counter ion selected from C104~, BR4~ , [FeCl 4 ] -, PF6(, RCOO~, N0 3 ~, RO0, N*(R) 4 , Cl~ 15 , Br~, F~, I-, CF 3 SO3 , S 2 0 6 2- , OCN , SCN , H 2 0 and BF 4 ~; a represents an integer from 1 to 4; k represents an integer from 1 to 10; n represents an integer from 1 to 4; m represents zero or an integer from 1 to 8; and 20 each R independently represents a group selected from hydrogen, optionally substituted alkyl and optionally substituted aryl. 25