AU783910B2 - Use of estrone derivatives as antitumour agents - Google Patents

Use of estrone derivatives as antitumour agents Download PDF

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Publication number
AU783910B2
AU783910B2 AU47668/00A AU4766800A AU783910B2 AU 783910 B2 AU783910 B2 AU 783910B2 AU 47668/00 A AU47668/00 A AU 47668/00A AU 4766800 A AU4766800 A AU 4766800A AU 783910 B2 AU783910 B2 AU 783910B2
Authority
AU
Australia
Prior art keywords
group
cells
compound
ring
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU47668/00A
Other languages
English (en)
Other versions
AU4766800A (en
Inventor
Barry Victor Lloyd Potter
Michael John Reed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sterix Ltd
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9910166.9A external-priority patent/GB9910166D0/en
Priority claimed from GB0002113A external-priority patent/GB0002113D0/en
Application filed by Sterix Ltd filed Critical Sterix Ltd
Publication of AU4766800A publication Critical patent/AU4766800A/en
Priority to AU2005225148A priority Critical patent/AU2005225148B2/en
Application granted granted Critical
Publication of AU783910B2 publication Critical patent/AU783910B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AU47668/00A 1999-04-30 2000-04-28 Use of estrone derivatives as antitumour agents Ceased AU783910B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2005225148A AU2005225148B2 (en) 1999-04-30 2005-10-25 Use

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9910166 1999-04-30
GBGB9910166.9A GB9910166D0 (en) 1999-04-30 1999-04-30 Use
US13952099P 1999-06-16 1999-06-16
US60/139520 1999-06-16
GB0002113A GB0002113D0 (en) 2000-01-28 2000-01-28 Use
GB0002113 2000-01-28
PCT/GB2000/001661 WO2000066095A2 (en) 1999-04-30 2000-04-28 Use of estrone derivatives as antitumour agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2005225148A Division AU2005225148B2 (en) 1999-04-30 2005-10-25 Use

Publications (2)

Publication Number Publication Date
AU4766800A AU4766800A (en) 2000-11-17
AU783910B2 true AU783910B2 (en) 2005-12-22

Family

ID=27255503

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47668/00A Ceased AU783910B2 (en) 1999-04-30 2000-04-28 Use of estrone derivatives as antitumour agents

Country Status (7)

Country Link
US (1) US8207152B2 (enExample)
EP (1) EP1173182A2 (enExample)
JP (1) JP5042411B2 (enExample)
AU (1) AU783910B2 (enExample)
IL (2) IL145995A0 (enExample)
NZ (1) NZ515061A (enExample)
WO (1) WO2000066095A2 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908910B2 (en) 1993-08-06 2005-06-21 The Children's Medical Center Corporation Estrogenic compounds as anti-mitotic agents
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
GB9913536D0 (en) * 1999-06-10 1999-08-11 Sterix Ltd Use
US7087592B1 (en) 1999-08-23 2006-08-08 Entre Med, Inc. Compositions comprising purified 2-methoxyestradiol and methods of producing same
US20020106348A1 (en) * 2000-07-12 2002-08-08 Peng Huang Cancer therapeutics involving the administration of 2-methoxyestradiol and an agent that increases intracellular superoxide anion
GB0020498D0 (en) 2000-08-18 2000-10-11 Sterix Ltd Compound
US6995278B2 (en) 2000-08-18 2006-02-07 Entre Med, Inc. Antiangiogenic agents
US7135581B2 (en) 2000-08-18 2006-11-14 Entremed, Inc. Antiangiogenic agents
AU8838601A (en) * 2000-11-27 2002-06-03 Entremed Inc Antiangiogenic agents
GB0113920D0 (en) 2001-06-07 2001-08-01 Sterix Ltd Composition
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
ATE317369T1 (de) * 2001-12-21 2006-02-15 Schering Ag Industriell anwendbares verfahren zur sulfamoylation von alkoholen und von phenolen
GB0306717D0 (en) * 2003-03-24 2003-04-30 Sterix Ltd Compound
AU2004224053B2 (en) * 2003-03-24 2011-06-09 Sterix Limited Oestrogen derivatives as inhibitors of steroid sulphatase
WO2005030120A2 (en) 2003-05-28 2005-04-07 Entremed, Inc. Antiangiogenic agents
EP1756139A4 (en) 2004-03-12 2009-07-29 Entremed Inc ANTI-ANGIOGENIC AGENTS
GB0421106D0 (en) * 2004-09-22 2004-10-27 Sterix Ltd Compound
CA2646065C (en) 2006-03-20 2014-01-14 Entremed, Inc. Disease modifying anti-arthritic activity of 2-methoxyestradiol
WO2023105303A1 (en) * 2021-12-06 2023-06-15 Kashiv Biosciences, Llc Compounds for the treatment of cancer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9003939D0 (en) * 1990-02-21 1990-04-18 Imperial College Sulphatase inhibitors
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
US6083978A (en) 1996-03-05 2000-07-04 Sterix Limited Compounds with a sulfamate group
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9603325D0 (en) 1996-02-16 1996-04-17 Imperial College A compound
GB9118465D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US6087347A (en) 1996-09-12 2000-07-11 Teikoku Hormone Mfg. Co., Ltd. 3-substituted-D-homo-1,3,5(10)-estratriene derivatives
US5763492A (en) * 1996-10-01 1998-06-09 Duguesne University Of The Holy Ghost Methods for effecting memory enhancement mediated by non-steroidal sulfatase inhibitors
US5880115A (en) 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
GB2331987B (en) * 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
GB2331988B (en) * 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
ATE401896T1 (de) * 1998-06-10 2008-08-15 Sterix Ltd Pharmazeutische zusammensetzungen mit tumor nekrose faktor und 2-methoxyestron-3-o-sulphamat als estrone sulphatasehemmern
GB9913536D0 (en) * 1999-06-10 1999-08-11 Sterix Ltd Use
US20030086924A1 (en) * 1999-06-25 2003-05-08 Genentech, Inc. Treatment with anti-ErbB2 antibodies

Also Published As

Publication number Publication date
EP1173182A2 (en) 2002-01-23
IL145995A (en) 2009-11-18
US8207152B2 (en) 2012-06-26
JP2002543114A (ja) 2002-12-17
WO2000066095A2 (en) 2000-11-09
NZ515061A (en) 2004-04-30
AU4766800A (en) 2000-11-17
IL145995A0 (en) 2002-07-25
WO2000066095A3 (en) 2001-08-09
JP5042411B2 (ja) 2012-10-03
US20060122161A1 (en) 2006-06-08

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