AU776102B2 - Matrix for transdermal drug delivery and pressure sensitive adhesive - Google Patents

Description

MATRIX FOR TRANSDERMAL DRUG DELIVERY AND PRESSURE SENSITIVE ADHESIVE Background of the Invention Field of the Invention This invention relates to drug containing matrices for use in transdermal drug delivery devices. In another aspect this invention relates to pressure sensitive skin adhesives. In yet another aspect this invention relates to pharmaceutical formulations involving a pressure sensitive skin adhesive layer.

Description of the Related Art Transdermal drug delivery devices are designed to deliver a therapeutically effective amount of drug across the skin of a patient. For example, JP-A-57011916 teaches a simple device having tape backing with adhesive and a drug on the surface of the adhesive. Other devices known to the art include reservoir type devices involving membranes that control the rate of drug release to the skin and devices involving membranes that control the :rate of drug release to the skin and devices involving a dispersion of the drug in a matrix. Certain acrylic copolymers have been used as matrices for delivery of specific drugs. It is critical in such devices that intimate skin contact be achieved and maintained between the skin and the drug-containing matrix.

Thus the range of copolymers that are suitable for use as matrices is limited by the ability of the copolymer to comply to the surface of the skin and still release cleanly from the skin. Moreover, the skin presents a substantial barrier to ingress of foreign substance such as drugs into the body. It is therefore often desirable or necessary to incorporate certain materials that enhance the rate at which the drug passes through the skin.

Certain transdermal drug delivery devices have incorporated pressure sensitive adhesive matrices. Fundamentally, PSAs require a balance of viscous and elastic properties which result in a four-fold balance of adhesion, cohesion, stretchiness, and elasticity. In essence, PSA products have sufficient cohesiveness and elasticity so that, despite their tackiness, they can be handled with the finner and removedl frm the sklin without !eavwnn substantial residue.

Summary of the Invention This invention provides a transdermal drug delivery device, comprising: a backing; a matrix adhered to one side of the backing and comprising a copolymer comprising one or more A monomers selected from the group 10 consisting of alkyl acrylates containing 4 to 10 carbon atoms in the alkyl group and alkyl methacrylates containing 4 to 10 carbon atoms in the alkyl group; and (ii) optionally one or more ethylenically unsaturated B monomers copolymerizable with the A monomer; and (iii) a macromonomer, preferably a substantially linear macromonomer, copolymerizable with the A and B monomers defined above and having a molecular weight in the range 500-500,000; a softener dissolved in the copolymer; and, if the softener is not therapeutically effective, a therapeutically effective amount of a drug, wherein the structure and amount of the comonomers in the copolymer, the inherent viscosity of the copolymer, and the amount and structure of the drug and the softener are such as to provide the matrix with a compliance value in the range 2 x 10~cm /N to about 4 x 10-cm2/N.

It has been found that the copolymer and the softener as defined above can be selected such that the resulting composition adheres to the skin.

Accordingly this invention also provides a pressure sensitive skin adhesive comprising: a copolymer comprising one or more A monomers selected from the group consisting of alkyl acrylates containing 4 to 10 carbon atoms in the alkyl group and alkyl methacrylates containing 4 to 10 carbon atoms in the alkyl group; and 3 optioally vone o more lency i unsy ra.ted B monomers copolymerizable with the A monomer; and a macromonomer copolymerizable with the A and B monomers defined above and having a molecular weight in the range 500- 500,000; and a softener dissolved in the copolymer, wherein the structure and amount of the comonomers in the copolymer, the inherent viscosity of the copolymer, and the amount and structure of the softener are such as to provide the pressure sensitive skin adhesive with a 10 compliance value in the range 2 x 10 11 cm 2 /N to about 4 x 10 cm 2

/N.

The invention provides a transdermal drug delivery device that allows dissolution of drug and relatively heavy loading with oily excipients, maintains contact with the skin, and can be removed cleanly from the skin. The pressure sensitive skin adhesives of the invention provide these advantages and in addition adhere to the skin.

Detailed Description of the Invention Throughout the description and claims of this specification the word "comprise" and variations of that word, such as "comprises" and "comprising", are not intended to exclude other additives or components or integers or steps.

The term "lower alkyl" as used herein means straight chain or branched chain alkyl containing 1 to 4 carbon atoms.

The present invention provides a transdermal drug delivery device having a backing and a matrix adhered to one side thereof. It can be adhered directly to a backing or it can be adhered indirectly to a backing via an intermediate layer.

The matrix contains a copolymer as defined above and a softener. The matrix is preferably a pressure sensitive skin adhesive. In addition, the matrix (whether adhesive or not) can be removed cleanly from the skin.

The copolymer utilized in the practice of the invention should be substantially chemically inert to other components utilized in conjugation therewith the drugs andlor softeners discussed in detail below). Also the inherent viscosity of the copolymer is such as to ultimately provide a suitable 3A transdermal matrix, preferably a pressure sensitive skin adhesive. Preferably the copolymer has an inherent viscosity in the range 0.2 dl/g to about 2 dl/g, more preferably in the range 0.4 dlg to 1.4 dl/g.

Suitable copolymers comprise one or more A monomers preferably in an amount about 40 to 95 percent by weight, more preferably about 50 to about percent by weight, based on the total weight of all monomers in the copolymer.

The A monomer is selected from the group consisting ofalkyl acrylates containing 4 to 10 carbon atoms in the alkyl group and alkyl methacrylates containing 4 to carbon atoms in the alkyl group. Examples of suitable alkyl acrylates and methacrylates are n-butyl, n-pentyl, n-hexyl, isoheptyl, n-nonyl, n-decyl, isohexyl, 2- 10 ethyloctyl, isooctyl and 2-ethylhexyl acrylates and methacrylates. Preferred alkyl acrylates include isooctyl acrylate, 2-ethylhexyl acrylate, butyl acrylate, and cyclohexyl acrylate. The most preferred alkyl acrylate is isooctyl acrylate.

Preferred alkyl methacrylates include butyl methacrylate, cyclohexyl methacrylate, isobornyl methacrylate, and methyl methacrylate.

The copolymer further optionally comprises one or more ethylenically :unsaturated B monomers copolymerizable with the A monomer. Suitable B monomers include those comprising a functional group selected from the group consisting of carboxylic acid, carboxylic acid ester, hydroxy, sulfonamide, urea, carbamate, carboxamide, amine, oxy, oxo, and cyano. The B monomers are preferably used in a total amount from 0 to about 60 percent by weight, more preferably greater than 25 to about 50 percent by weight, and most preferably S. greater than 30 to about 50 percent by weight (based on the total weight of all the monomers in the copolymer). Preferred B monomers include but are not limited to acrylic acid, methacrylic acid, maleic acid, a hydroxyalkyl acrylate containing 2 to 4 carbon atoms in the hydroxyalkyl group, a hydroxyalkyl methacrylate containing 2 to 4 carbon atoms in the hydroxyalkyl group, acrylamide, methacrylamide, an alkyl substituted acrylamide containing 1 to 8 carbon atoms in the alkyl group, diacetone acrylamide, a dialkyl acrylamide having 1 or 2 carbon atoms in the alkyl group, Nvinyl-N-methyl acetamide, N-vinyl valerolactam, N-vinyl caprolactam, N-vinyl-2pyrrolidone, glycidyl methacrylate, alkoxyethyl acrylate containing 1 to 4 carbon atoms in the alkoxy group, alkoxyethyl methacrylate containing 1 to 4 carbon atoms in the alkoxy group, 2-ethoxyethoxyethyl acrylate, furfuryl methacrylate, furfuryl acrylate, tetrahydrofurfuryl acrylate, tetrahydrofurfuryl methacrylate, propylene glycol monomethacrylate, propylene glycol monoacrylate, polyethylene glycol acrylate, polyethylene glycol methyl ether acrylate, polyethylene glycol methacrylate, polyethylene oxide methyl ether acrylate, di(lower)alkylamino ethyl acrylate, di(lower)alkylamino ethyl methacrylate, di(lower)alkylaminopropyl methacrylamide, acrylonitrile, methacrylonitrile, and vinyl acetate.

Particularly preferred B monomers include hydroxyethyl acrylate, acrylamide, hydroxyethyl methacrylate, glyceryl acrylate, N,N-dimethyl acrylamide, 10 2-ethoxyethoxyethyl acrylate, 2-ethoxyethyl acrylate, tetrahydrofurfuryl acrylate, vinyl acetate and acrylic acid. Most preferred B monomers include hydroxyethyl .acrylate and N,N-dimethyl acrylamide, and a combination thereof As noted in detail below, the compositions of the invention can contain a relatively high loading of softener. In order to accommodate such loadings the copolymer incorporates a macromonomer, preferably a substantially linear S. macromonomer, copolymerizable with the A and B monomers defined above and having a molecular weight in the range 500-500,000, preferably 2,000-100,000, and more preferably 5,000-30,000, in an amount at least about 0.1 percent by weight based on the total weight of comonomers in the copolymer) effective to 20 control the rheological properties of the copolymer. The macromonomer is generally present in an amount of not more than about 30% by weight based on the total weight of all monomers in the copolymer, more preferably not more than and most preferably not more than The macromonomer can be a compound of the formula

R

2

X(C-CH

2

).R

3

R

wherein X is a moiety comprising an ethylenically unsaturated group (such as

-CH

2

-C=CH

2

-CH=C(CH

3

)(CO

2

CH

3 vinyl, or 2-propenyl) copolymerizable with C0 2 d11 3 the A and B monomers, R 2 is a hydrogen atom or a lower alkyl group, R.

3 is a lower alkyl group or the residue of a free-radical initiator, n is an integer from 20 to 500 and each R" is a monovalent radical independently selected from the group consisting of

R

-CN, and -C0 2

R

6 wherein R5 is a hydrogen atom or a lower alkyl group, and R 6 is a :lower alkyl group. Suitable macromonomers include polymethylmethacrylate, styrene/acrylonitrile, And polystyrene macromonomers. Polymethylmethacrylate rnacromonomers are preferred.

:.Exemplary macromonomers include those having a general formula selected from the group consisting of 11 1

H

2

C=C-C-O-C-CH

2 (C-CH2)R 3 R' 7 R 4 *4 0 0OH R 2

H

2 C=C-C-0-CH 2

C

2

NH-C--C-CH(C-C

2 K7 R'R

R

7 R 2 I I H K H R 2 IZ I

CH

2

-O-C-CH

2 (C-CH2)R 3

H

2 C=CHOMZ I I 0 H R2 RI i I

H

2

C=C-O-C-CH

2

-O-C-CH

2 (C-CH).R 3 1 1 1 AR7 R 4 R 2 CH2=C-CH--(C-CH 2 3 I I

COL

2 CHk 3 Rw H R 2 I I

H

2

C=CH-OCH

2

CH

2

-O-C-CH

2

(C-CH

2 )nR 3 I I

R

7

R

4 wherein R 7 is a hydrogen atom or a lower alkyl group, R 8 is hydrogen or methyl, and R 2

R

3 and R 4 are as defined above.

The macromonomers shown in the formulae directly above are functionally terminated polymers having a single functional group and are sometimes identified as a "semitelechelic" polymers. (Vol. 27 "Functionally Terminal Polymers via Anionic Methods" D. N. Schultz et al., pages 427-440, Anionic Polymerization, 15 American Chemical Society (1981)). Such macromonomers are known and may be prepared by the method disclosed in U.S. Pat. Nos. 3,786,116, 3,842,059 (both to Milkovich et and 4,732,808 (Krampe et the disclosures of which are incorporated herein by reference for the description of the preparation of the macromonomers. Certain macromonomers are commercially available, for example those polymethylmethacrylate macromonomers sold under the trade designation "ELVACITE" by ICI Acrylics ELVACITE 1010, a polymethylmethacrylate macromonomer having an inherent viscosity of 0.070-0.080, a T, of 105 0 C, a GPC weight average molecular weight of 7,000-10,000, a GPC number average molecular weight of 2,500-4,000, and a polydispersity of 2.5-3.0, and ELVACITE 25 1020, a polymethylmethacrylate macromonomer having an inherent viscosity of 0.085-0.10, a T 8 of 105°C, a GPC weight average molecular weight of 12,000- 15,000, a GPC number average molecular weight of 4,600-6,000, and a polydispersity of 2.5-3.0).

A matrix of the invention further comprises a softener. The softener is dissolved in the matrix. As used herein the term "softener" refers to a generally oily material that raises the compliance value or lowers the glass transition temperature of the matrix as compared to the copolymer.

Suitable softeners include certain materials that have been used as skin penetration enhancers or solubilizers in transdermal drug delivery systems.

9 Exemplary materials include C 8

-C

22 fatty acids such as isostearic acid, octanoic acid, and oleic acid, C 8 -C2 fatty alcohols such as oleyl alcohol and lauryl alcohol, lower alkyl esters of C 8

-C

22 fatty acids such as ethyl oleate, isopropyl myristate, butyl stearate, and methyl laurate, di(lower) alkyl esters of C 6

-C

8 diacids such as diisopropyl adipate, monoglycerides of C 8

-C

22 fatty acids such as glyceryl monolaurate, tetrahydrofurfuryl alcohol polyethylene glycol ether, polyethylene glycol, propylene glycol, ethoxyethoxy ethanol, 2-(2ethoxyethoxy)ethanol, diethylene glycol monomethyl ether, N,Ndimethyldodecylamine-N-oxide, and combinations of the foregoing. Alkylaryl 10 ethers of polyethylene oxide, polyethylene oxide monomethyl ethers, and polyethylene oxide dimethyl ethers are also suitable, as are solubilizers such as dimethyl sulfoxide, glycerol, ethanol, ethyl acetate, acetoacetic ester, N-methyl pyrrolidone, and isopropyl alcohol. Likewise certain drug substances function as softeners, including nicotine, nitroglycerine, chlorpheniramine, nicotinic acid benzyl ester, orphenadrine, scopolamine, and valproic acid.

Preferred softeners include glyceryl monolaurate, diethylene glycol monomethyl ether, tetrahydrofurfuryl alcohol polyethylene glycol ether, diisopropyl adipate, propylene glycol, isopropyl myristate, ethyl oleate, methyl laurate, 2-(2-ethoxyethoxy)ethanol, and oleyl alcohol.

Preferably the softener is present in not more than that amount which causes the matrix to leave substantial copolymer residue on the skin when peeled from the skin.

While many of the softeners enumerated above are known to effect skin penetration rate, certain softeners affect aspects of performance other than and in addition to skin penetration rate. For example, they are useful in softening or increasing the compliance value and/or lowering the glass transition temperature of otherwise non-compliant (and therefore non-pressure sensitive adhesive) copolymers, rendering them suitable for use as pressure sensitive skin adhesives. However, the softeners enumerated above are generally oily substances that function as plasticizers when incorporated in a copolymer.

Such materials can affect adversely the performance of a transdermal matrix, for example by softening it to the point of cohesive failure (where substantial copolymer residue is left on the skin upon removal of the device from the skin), or by separating from the continuous phase and forming an oily layer that reduces adhesion of an otherwise adhesive matrix. Also, certain softeners glyceryl monolaurate, N,Ndimethyldodecylamnine-N-oxide) can crystallize in the copolymer, resulting in unstable properties unstable drug delivery rates in a transdermal drug delivery device).

Possible adverse effects of soft eners notwithstanding, with proper selection of softeners, monomers and relative amounts thereof, and -inherent viscosity of the copolymer, softeners can be included in amounts of up to about 60% by weight based on the total weight of the matrix without cohesive failure or crystal formation, and often without loss of suitable skin adhesion. Softener amounts in excess of 20% and preferably less than about 45% by weight based on the total weight of the matrix have been found to be preferred in order to obtain optimal flux rates in transdermal devices containing the hormone levonorgestrel, and amounts in excess of 30% and less than 45% are more preferred.

The properties desirable in a transderinal matrix are well known to those skilled in the art. For example, it is necessary that the matrix remain in intimate contact with the skin in order to deliver drug at a stable rate. It is desirable for a matrix to have sufficiently little cold flow such that it is stable to flow upon storage.

It is also preferred that it release cleanly from the skin, and that it adhere to the skin.

:In order to achieve skin contact, clean release, preferred levels of adhesion, and resistance to cold flow the amount and structure of the cornonomers in the copolymer, the inherent viscosity of the copolymer, and the amount and structure of the softener are selected such that the matrix has a compliance value (measured according to the test method set forth in detail below) in the range 2 x 10'6 cm 2 /dyne to about 4 x 10,3 cm 2 /dyne, preferably in the range 3 x I e' cm 2 /dyne to about I x 10-3 cm 2 /dyne and even more preferably in the range I X 10, Q.S cmdyne to x 104 cm 2 /dyne. Compliance values outside the broad range recited above sometimes are obtained from materials that are suitable matrices, and even for some that are suitable for use as pressure sensitive skin adhesives. However, those matrices having substantially lower compliance values will generally be relatively stiff and have less than optimal skin contact and adhesion to skin. Those having substantially higher compliance values will generally have less than optimal cold flow and might leave substantial residue when removed from the skin. Also, a matrix of the invention that is intended for use as a pressure sensitive skin adhesive preferably has a glass transition temperature of -10 0 C or lower.

Particularly suitable compositions can be readily selected for a given set of desired properties considering the effects ofcomonomers, inherent viscosity, and softeners on the properties of the resulting matrix. Certain of such effects are well known to those skilled in the art, and others are described below: 1. 0 Strongly hydrogen bonding B monomers have been found to increase the i' .amount of polar or hydrogen bonding substances that can be dissolved in a matrix and to decrease the amount of generally nonpolar substances that can be dissolved.

Further, a strongly hydrogen bonding copolymer will be a relatively less compliant material. Therefore ifB monomers such as acrylic acid or acrylamide are used a lesser amount of macromonomer will be required in order to lower compliance sufficiently to avoid cohesive failure.

S .Macromonomers also decrease compliance. Therefore a given target compliance value can often be achieved using a lower inherent viscosity A/B copolymer combination and a greater amount of macromonomer, or a higher 20 inherent viscosity A/B combination and less macromonomer.

A relatively high compliance pressure sensitive skin adhesive involving a macromonomer will generally have better adhesive properties than an A/B copolymer having the same compliance value. Increasing macromonomer content generally increases the amount of softener that can be loaded into a pressure sensitive skin adhesive without cohesive failure. Increasing inherent viscosity will also tend to allow higher softener loading without cohesive failure.

A change that would increase inherent viscosity of a copolymer (such as increased molecular weight through selection of polymerization conditions and/or solvent ratios) will generally decrease compliance.

Further conventional components, such as stabilizers and reinforcers (e.g.

colloidal silicon dioxide), can be incorporated into the matrix if necessary or desirable.

Of course such high levels of certain individual softeners N,Ndimethyldodecylamine-N-oxide) are to be avoided in order to avoid excessive skin irritation.

The matrix of a transdermal drug delivery device of the invention further comprises a drug. Suitable drugs include those active substances enumerated above in connection with softeners, as well as antiinflammatory drugs, both steroidal hydrocortisone, prednisolone, triamcinolone) and nonsteroidal naproxen, piroxicam); antibacterials penicillins such as penicillin V, cephalosporins such as cephalexin, erythromycin, tetracycline, gentamycin, sulfathiazole, nitrofurantoin, and quinolones such as norfloxacin, flumequine, and ibafloxacin); antiprotazoals metronidazole); antifungals nystatin); coronary vasodilators nitroglycerin); calcium channel blockers nifedipine, diltiazem); bronchodilators theophylline, pirbuterol, salmeterol, isoproterenol); enzyme inhibitors such as collagenase inhibitors, protease inhibitors, elastase inhibitors, lipoxygenase inhibitors A64077), and angiotensin converting enzyme inhibitors captopril, lisinopril); other antihypertensives propranolol); leukotriene antagonists ICI204,219); anti-ulceratives such as H2 antagonists; steroidal hormones progesterone, testosterone, estradiol, levonorgestrel); antivirals and/or immunomodulators I1-isobutyl-l H-imidazo[4,5-c]quinolin-4-amine, 1-(2-hydroxy-2-methylpropyl)-I H-imidazo[4,5-c]quinoline-4-amine, and other compounds disclosed in U.S. Pat. No. 4,689,338, incorporated herein by reference, acyclovir); local anesthetics benzocaine, propofol); cardiotonics digitalis, digoxin); antitussives codeine, dextromethorphan); antihistamines diphenhydramine, chlorpheniramine, terfenadine); narcotic analgesics morphine, fentanyl); peptide hormones human or animal growth hormones, LHRH); cardioactive products such as atriopeptides; proteinaceous products insulin); enzymes anti-plaque enzymes, lysozyme, dextranase); antinauseants scopolomine); anticonvulsants carbamazine); immunosuppressives -12cyclosporine); psychotherapeutics diazepam); sedatives phenobarbital); anticoagulants heparin); analgesics acetaminophen); antimigraine agents ergotamine, melatonin, sumatriptan); antiarrhythmic agents flecainide); antiemetics metaclopromide, ondansetron); anticancer agents methotrexate); neurologic agents such as anxiolytic drugs; hemostatics; anti-obesity agents; and the like, as well as pharmaceutically acceptable salts and esters thereof.

The drug is present in a transdermal delivery device of the invention in a therapeutically effective amount, an amount effective to bring about a desired therapeutic result in the treatment of a condition. The amount that constitutes a 10 therapeutically effective amount varies according to the particular drug incorporated in the device, the condition being treated, any drugs being coadministered with the selected drug, desired duration of treatment, the surface area of the skin over which the device is to be placed, and other components of the transdermal delivery device. Accordingly it is not practical to enumerate particular preferred amounts but such can be readily determined by those skilled in the art with due consideration of these factors. Generally, however, a drug is present in a Stransdermal device of the invention in an amount of about 0.01 to about 30 percent by weight based on the total weight of the matrix. In a preferred embodiment the S" drug is substantially fully dissolved, and the matrix is substantially free of solid undissolved drug.

A transdermal delivery device or an adhesive coated sheet material of the invention also comprises a backing. The backing is flexible such that the device conforms to the skin. Suitable backing materials include conventional flexible backing materials used for pressure sensitive tapes, such as polyethylene, particularly low density polyethylene, linear low density polyethylene, high density polyethylene, polyester, polyethylene terephthalate, randomly oriented nylon fibers, polypropylene, ethylene-vinyl acetate copolymer, polyurethane, rayon and the like.

Backings that are layered, such as polyethylene-aluminum-polyethylene composites, are also suitable. The backing should be substantially inert to the ingredients of the matrix layer.

The copolymers described above for use in a device of the invention can be prepared by Methods well known to those skilled in the art and described, for example, in U.S. Patent RE 24,906 (Ulrich) and U.S. Pat. No. 4,732,808 (Kranipe at the disclosures of which are incorporated herein by reference.

Matrices of the invention can be used in the form of an adhesive coated sheet material. Such sheet materials are preferably prepared by combining the copolymner, the softener, and any additional components a drug) with an organic solvent ethyl acetate, methanol, acetone, 2-butanone, ethanol, isopropyl alcohol, toluene, alkanes, or a mixture thereof) to afford a coating formulation. The total solids content of the coating formulation is preferably in a *~.range of about 15 to 40 percent by weight, and more preferably in the range of about 20 to 35 percent by weight, based on the total weight of the coating formulation. The components of the coating formulation are combined and mixed by shaking or rolling) until a homogeneous formulation is obtained, then allowed to stand to dissipate air bubbles. The resulting coating formulation is knife :coated onto a suitable release liner to provide a predetermined uniform thickness of the coating formulation. Suitable release liners include conventional release liners comprising a known sheet material such as a polyester web, a polyethylene web, or a polystyrene web, or a polyethylene-coated paper, coated with a suitable fluoropolymer or silicone based coating. The coated release liner is dried and then lamidnated onto a backing material using conventional methods. Alternatively the coating formulation can be coated directly onto a backing. A transderrnal device involving a matrix that is not a skin adhesive can be fixed to the skin by conventional means such as a peripheral ring of a pressure sensitive skin adhesive.

Adhesive coated sheet materials of the invention can be made in the form of an article such as a tape, a patch, a sheet, a dressing or any other form known to those skilled in the art. Transdermal drug delivery devices generally are made in the form of a patch of a size suitable to deliver a preselected amount of a drug through the skin. Generally the transdermal device will have a surface area of about I cm 2 to about 40 cm 2 The examples set forth below are intended to illustrate the invention.

Compliance Test Method The compliance values given in the examples below were obtained using a modified version of the Creep Compliance Procedure described in U.S. Pat. No.

4,737,559 (Kellen), the disclosure of which is incorporated herein by reference.

The release liner is removed from a sample of the material to be tested. The exposed adhesive surface is folded back on itself in the lengthwise direction to produce a "sandwich" configuration, backing/adhesive/backing. The "sandwiched" sample is passed through a laminator, or alternatively rolled with a hand-operated roller, then two test samples of equal area are cut using a rectangular die. One test sample is centered on a first stationary plate of a shear-creep rheometer with the long axis of the test sample centered on the short axis of the plate. The small, non-stationary plate of the shear-creep rheometer is centered over the first sample on the first stationary plate such that the hook is facing up and toward the front of the rheometer. The second test sample is centered on the upper surface of the small, non-stationary plate matching the axial orientation of the first test sample. A second stationary plate is placed over the second test sample and the entire assembly is clamped into place. The end of the small, non-stationary plate that is opposite the end with the hook is connected to a chart recorder. A string is connected to the hook of the small, non-stationary plate and extended over the front pulley of the rheometer. A weight 500 g) is attached to the free end of the :string. The chart recorder is started and at the same time the weight is quickly released so that it hangs free. The weight is removed after exactly 3 minutes has elapsed. The displacement is read from the chart recorder. The compliance is then calculated using the equation:

AX

hf where A is the area of one face of the test sample, h is the thickness of the adhesive mass two times the matrix thickness of the sample being tested), X is the displacement and fis the force due to the mass attached to the string. Where A is expressed in cm 2 h in cm, X in cm and fin dynes, the compliance value is given in cm 2 /dyne.

Determination of sopropyl Myristate Content The amount of isopropyl myristate present in a pressure sensitive skin adhesive composition was determined using the following test method. The release liner is removed from a sample of the material to be tested. The adhesive coating is manually scraped from the backing film. A 15 mg portion of the adhesive coating is placed into a clean sample vial. Tetrahydrofuran (2 mL containing 0.10 mg/mL of **10 lauryl acrylate which serves as an internal standard) is added and the sample is mixed until all of the adhesive coating is dissolved. A portion of the solution is placed in an autosampler vial and analyzed by gas chromatography using the following conditions: Instrument: HP5890; Column: DB-5, 30 meter, 0.25 pM film, "0.25 mm Temperature Program: Initial 100 0 C, ramp 10 0 C/min to 300 0 C, hold 2 min; Injection: 2 tL, split 25/1, 300 0 C; Detection: FID, 300 0 C. Isopropyl S. myristate standards are prepared using copolymer samples containing no isopropyl myristate. Separate standard curves are prepared for each copolymer. Each sample is run in duplicate.

Determination of Oleyl Alcohol Content The amount of oleyl alcohol present in a pressure sensitive skin adhesive composition was determined using the following test method. The release liner is removed from a sample of the material to be tested. The adhesive coating is manually scraped from the backing film. A 15 mg portion of the adhesive coating is placed into a clean sample vial. Tetrahydrofuran (10 mL containing 0.1 mg/mL of dodecyl alcohol which serves as an internal standard) is added and the sample is mixed until all of the adhesive coating is dissolved. A portion of the solution is placed in an autosampler vial and analyzed by gas chromatography using the following conditions: Instrument: HP5890; Column: DB-wax, 15 meter, 0.25 pM film, 0.25 mm Temperature Program: Initial 60 0 C, ramp 7 0 C/min to 2500C, hold 2 min; Injection: 2 pL, split 25/1, 250 0 C; Detection: FID, 250 0 C. Oleyl -16alcohol standards are prepared using copolymer samples containing no oleyl alcohol. Separate standard curves are prepared for each copolymer. Each sample is run in duplicate.

Preparation of Copolymers The copolymers used in the examples that follow were prepared generally according to the methods described below. The inherent viscosity values which are reported were measured by conventional means using a Cannon-Fenske viscometer in a water bath controlled at 27°C to measure the flow time of 10 milliliters of a polymer solution (0.15-0.25 g per deciliter of polymer in ethyl acetate, unless other wise indicated). The test procedure followed and the apparatus used are described in detail in "Textbook of Polymer Science", F. W.

Billmeyer, Wiley Interscience, Second Edition, 1971, Pages 84 and Preparation of sooctyl Acrylate: Dimethylacrylamide: Hydroxyethyl Acrylate: Polymethylmethacrylate Macromonomer (60/15/15/10) Copolymer Isooctyl acrylate (141.0 N,N-dimethylacrylamide (35.25 hydroxyethyl acrylate (35.25 ELVACITE' 1010 polymethylmethacrylate macromonomer (23.50 g, ICI), ethyl acetate (251.75 isopropanol (13.25 g) and 2,2'-azobis(2,4dimethylpentanenitrile) (0.47 g, VAZO' M 52 available from DuPont) were charged into a one liter bottle. The mixture was deoxygenated by purging with nitrogen (1L/min) for 2 minutes. The bottle was sealed and placed in a rotating water bath at for 24 hours. The bottle was removed, opened, charged with an additional 0.47 g of VAZO 52, repurged with nitrogen as before, sealed and placed in the launderometer for an additional 24 hours. The percent solids of the resulting solution of copolymer was 45.51%. The inherent viscosity was 0.469 deciliter/gram in ethyl acetate at 0.25 g/dl.

Preparation ofIsooctyl Acrylate: Dimethylacrylamide: Polymethylmethacrylate Macromonomer (50/40/10) Copolymer Isooctyl acrylate (117.5 N,N-dimethylacrylamide (94.0 ELVACITE' m 1010 polymethylmethacrylate macromonomer (23.5 ethyl acetate (251.75 g), isopropanol (13.25 g) and VAZO 52 (0.47 g) were charged into a one liter bottle.

The mixture was deoxygenated by purging with nitrogen (IL/min) for 2 minutes.

The bottle was sealed and placed in a rotating water bath at 45 0 C for 24 hours. The bottle was removed, opened, charged with an additional 0.47 g of VAZO 52, 10 repurged with nitrogen as before, sealed and placed in the launderometer for an additional 24 hours. The percent solids of the resulting solution of copolymer was 46.19%. The inherent viscosity was 0.532 dlg in ethyl acetate at 0.25 g/dl.

*0 Preparation ofIsooctyl Acrylate: Dimethylacrylamide: Polymethylmethacrylate Macromonomer (63/27/10) Copolymer go Isooctyl acrylate (157.5 N,N-dimethylacrylamide (67.5 ELVACITE 1010 macromonomer (25.0 ethyl acetate (261.25 isopropanol (13.75 g) and *0 S *VAZO 52 (0.5 g) were charged into a one liter bottle. The mixture was 20 deoxygenated by purging with nitrogen (IL/min) for 3 minutes. The bottle was sealed and placed in a rotating water bath at 45°C for 24 hours. The bottle was removed, opened, charged with an additional 0.5 g of VAZO 52, repurged with nitrogen as before, sealed and placed in the launderometer for an additional 24 hours. The percent solids of the resulting solution of copolymer was 47.8%. The inherent viscosity was 0.394 dl/g in ethyl acetate at 0.15 g/dl.

Preparation ofIsooctyl Acrylate: Hydroxyethyl Acrylate: Polymethylmethacrylate Macromonomer (55/40/5) Copolymer Molecular sieves (50 g of 8-12 mesh, 4A, 1.6 mm beads) were added to each of 4 quart (0.95 L) wide mouth jars. The jars were filled with isooctyl acrylate, hydroxyethyl acrylate, ethyl acetate, and isopropanol respectively. The jars were tightly capped and allowed to stand for at least 24 hours. The molecular sieves were then removed by filtration through Whatman filter paper No. 4. The 10 "dry" monomers and solvents were then stored in tightly capped bottles until used to prepare copolymer. Isooctyl acrylate (137.5 hydroxyethyl acrylate (100.0 g), see& ELVACITE M 1010 polymethylmethacrylate macromonomer (12.5 ethyl acetate (318.75 isopropanol (56.25 g) and VAZO 52 (0.5 g) were charged into a one liter bottle. The mixture was deoxygenated by purging with nitrogen (1L/min) for 3 minutes. The bottle was sealed and placed in a rotating water bath at 45 0 C for 24 hours. The bottle was removed, opened, charged with an additional 0.5 g of VAZO 52, repurged with nitrogen as before, sealed and placed in the launderometer for an additional 24 hours. The percent solids of the resulting solution of copolymer was 39.30%. The inherent viscosity was 0.335 d/g in ethyl acetate at 0.15 g/dl.

Preparation of Isooctyl Acrylate: Hydroxyethyl acrylate: Polystyrene Macromonomer (54/36/10) Copolymer Isooctyl acrylate (135 hydroxyethyl acrylate (90 polystyrene macromonomer (25.0 ethyl acetate (356.25 isopropanol (18.75 g) and VAZO 52 (0.5 g) were charged into a one liter bottle. The mixture was deoxygenated by purging with nitrogen (IL/min) for 3 minutes. The bottle was sealed and placed in a rotating water bath at 45 0 C for 24 hours. The bottle was removed, opened, charged with an additional 0.5 g of VAZO 52, repurged with nitrogen as before, sealed and placed in the launderometer for an additional 24 hours. The percent solids of the resulting solution of copolymer was 41.2%. The inherent viscosity was 0.75 dl/g in ethyl acetate at 0.15 g/dl.

Preparation ofIsooctyl Acrylate: Hydroxyethyl acrylate: Polystyrene Macromonomer (54/36/10) Copolymer Isooctyl acrylate (135 hydroxyethyl acrylate (90 polystyrene macromonomer (25.0 ethyl acetate (318.75 isopropanol (56.25 g) and VAZO 52 (0.5 g) were charged into a one liter bottle. The mixture was deoxygenated by purging with nitrogen (IL/min) for 3 minutes. The bottle was sealed and placed in a rotating water bath at 45 0 C for 24 hours. The bottle was removed, opened, charged with an additional 0.5 g of VAZO 52, repurged with nitrogen as before, sealed and placed in the launderometer for an additional 24 hours. The percent solids of the resulting solution of copolymer was 39.6%. The inherent viscosity was 0.29 dl/g in ethyl acetate at 0.15 g/dl.

Preparation of Isooctyl Acrylate:Polystyrene Macromonomer (95/5) Copolymer 20 Isooctyl acrylate (237.5 polystyrene macromonomer (12.5 ethyl acetate (261.25 isopropanol (13.75 g) and VAZO 52 (0.5 g) were charged into a one liter bottle. The mixture was deoxygenated by purging with nitrogen (IL/min) for 3 minutes. The bottle was sealed and placed in a rotating water bath at 45 0 C for 24 hours. The bottle was removed, opened, charged with an additional 0.5 g of VAZO 52, repurged with nitrogen as before, sealed and placed in the launderometer for an additional 24 hours. The percent solids of the resulting solution of copolymer was 47.5%. The inherent viscosity was 0.45 dl/g in ethyl acetate at 0.15 g/dl.

Preparation oflsooctyl Acrylate: Vinyl Acetate: Polystyrene Macromonomer (61/37/2) Copolymer Isooctyl acrylate (134.2 vinyl acetate (81.4 polystyrene macromonomer (4.4 2,2'-azobis(isobutyronitrile) (0.55 ethyl acetate (126.0 and toluene (54.0 g) were charged into a one liter bottle. The mixture was deoxygenated by purging with nitrogen (1 L/min) for 2 minutes. The bottle was sealed and placed in a rotating water bath at 60"C for 24 hours. The resulting copolymer solution was diluted with ethyl acetate (150 mL). The inherent viscosity in ethyl acetate at 0.2 g/dl was measured at 0.87 dl/g.

Preparation of Isooctyl Acrylate: Vinyl Acetate: Polystyrene Macromonomer (61/37/2) Copolymer Isooctyl acrylate (134.2 vinyl acetate (81.4 polystyrene macromonomer (4.4 2,2'-azobis(isobutyronitrile) (0.55 ethyl acetate (144.0 and toluene (36.0 g) were charged into a one liter bottle. The mixture was deoxygenated by purging with nitrogen (1 L/min) for 2 minutes. The bottle was sealed and placed in a rotating water bath at 60 0 C for 24 hours. The resulting 20 copolymer solution was diluted with ethyl acetate (150 mL). The inherent viscosity in ethyl acetate at 0.2 g/dl was measured at 1.02 dl/g.

Preparation of Isooctyl Acrylate: Vinyl Acetate: Polystyrene Macromonomer (58/37/5) Copolymer Isooctyl acrylate (127.6 vinyl acetate (81.4 polystyrene macromonomer (11.0 2,2'-azobis(isobutyronitrile) (0.55 ethyl acetate (126.0), and toluene (54.0 g) were charged into a one liter bottle. The mixture was deoxygenated by purging with nitrogen (1 L/min) for 2 minutes. The bottle was sealed and placed in a rotating water bath at 60 0 C for 24 hours. The resulting copolymer solution was diluted with ethyl acetate (150 mL). The inherent viscosity in ethyl acetate at 0.2 g/dl was measured at 0.89 dl/g.

Preparation of Isooctyl Acrylate: Vinyl Acetate: Polystyrene Macromonomer (58/37/5) Copolymer Isooctyl acrylate (127.6 vinyl acetate (81.4 polystyrene macromonomer (11.0 2,2'-azobis(isobutyronitrile) (0.55 ethyl acetate (144.0), and toluene (36.0 g) were charged into a one liter bottle. The mixture was deoxygenated by purging with nitrogen (1 L/min) for 2 minutes. The bottle was sealed and placed in a rotating water bath at 60 0 C for 24 hours. The resulting copolymer solution was diluted with ethyl acetate (150 mL). The inherent viscosity in ethyl acetate at 0.2 g/dl was measured at 1.02 dl/g.

Preparation of Isooctyl Acrylate: Vinyl Acetate: Polymethylmethacrylate Macromonomer (58/37/5) Copolymer Isooctyl acrylate (145.0 vinyl acetate (92.5 ELVACITET 1020 S. polymethylmethacrylate macromonomer (12.5 2,2'-azobis(2,4- 20 dimethylpentanenitrile) (0.5 and ethyl acetate (282.0) were charged into a one liter bottle. The mixture was deoxygenated by purging with nitrogen (1 L/min) for 3 minutes. The bottle was sealed and placed in a rotating water bath at 45*C for 24 hours. The bottle was removed from the bath, opened, charged with an additional g of 2,2'-azobis(2,4-dimethylpentanenitrile), deoxygenated as before, sealed and returned to the rotating water bath for an additional 24 hours. The inherent viscosity in ethyl acetate at 0.15 g/dl was measured at 1.05 dug.

Preparation of Isooctyl Acrylate: Vinyl Acetate: Polymethylmethacrylate Macromonomer (58/37/5) Copolymer Isooctyl acrylate (145.0 vinyl acetate (92.5 ELVACITET M 1020 polymethylmethacrylate macromonomer (12.5 2,2'-azobis(2,4dimethylpentanenitrile) (0.5 and ethyl acetate (250.0) were charged into a one liter bottle. The mixture was deoxygenated by purging with nitrogen (1 L/min) for 3 minutes. The bottle was sealed and placed in a rotating water bath at 45 0 C for 24 hours. The bottle was removed from the bath, opened, charged with an additional 0.5 g of 2,2'-azobis(2,4-dimethylpentanenitrile), deoxygenated as before, sealed and returned to the rotating water bath for an additional 24 hours. The inherent viscosity in ethyl acetate at 0.15 g/dl was measured at 1.15 dl/g.

Preparation of Isooctyl Acrylate: Vinyl Acetate: Polymethylmethacrylate Macromonomer (53/37/10) Copolymer Isooctyl acrylate (132.5 vinyl acetate (92.5 ELVACITE T M 1020 polymethylmethacrylate macromonomer (25.0 2,2'-azobis(2,4dimethylpentanenitrile) (0.5 and ethyl acetate (230.8) were charged into a one 20 liter bottle. The mixture was deoxygenated by purging with nitrogen (1 L/min) for 3 minutes. The bottle was sealed and placed in a rotating water bath at 45°C for 24 hours. The bottle was removed from the bath, opened, charged with an additional 0.5 g of 2,2'-azobis(2,4-dimethylpentanenitrile), deoxygenated as before, sealed and returned to the rotating water bath for an additional 24 hours. The inherent viscosity in ethyl acetate at 0.15 g/dl was measured at 0.815 dl/g.

Preparation of Isooctyl Acrylate: Vinyl Acetate: Polymethylmethacrylate Macromonomer (53/37/10) Copolymer Isooctyl acrylate (132.5 vinyl acetate (92.5 ELVACITE T M 1020 polymethylmethacrylate macromonomer (25.0 2,2'-azobis(2,4- -23dimethylpentanenitrile) (0.5 and ethyl acetate (204.5) were charged into a one liter bottle. The mixture was deoxygenated by purging with nitrogen (1 L/min) for 3 minutes. The bottle was sealed and placed in a rotating water bath at 45 0 C for 24 hours. The bottle was removed from the bath, opened, charged with an additional 0.5 g of 2,2'-azobis(2,4-dimethylpentanenitrile), deoxygenated as before, sealed and returned to the rotating water bath for an additional 24 hours. The inherent viscosity in ethyl acetate at 0.15 g/dl was measured at 0.92 dl/g.

Preparation of "Dried" Adhesive Dried adhesive is prepared by knife coating a 25 to 50 percent solids solution of the adhesive copolymer at a thickness of 20 to 25 mil (500 to 635 lM) onto a release liner. The adhesive coated release liner is oven dried 4 min at 110°F (43 0 2 minutes at 185 0 F and 10 minutes at 300"F (149 0 to remove solvent and reduce the amount of residual monomers. The dried adhesive copolymer is stripped off the release liner and stored in a glass container.

In the examples that follow all percentages are weight/weight unless otherwise indicated. The weight percentages of the formulations after drying are calculated values, unless otherwise indicated, and assume that only solvent was 20 evaporated during the drying process. The abbreviations IOA, HEA, DMACM, PSMac, PMMAMac, and VoAc are used for isooctyl acrylate, hydroxyethyl acrylate, dimethylacrylamide, polystyrene macromonomer, polymethylmethacrylate macromonomer, and vinyl acetate respectively. The polystyrene macromonomer used in the copolymers in the examples below is that macromonomer designated as Example M-1 in U.S. Pat. No. 4,732,808 (Krampe). Except as noted, the polymethylmethacrylate macromonomer used was ELVACITE 1010. The abbreviations BS, DDAO, DGME, DIPA, EO, GML, IPM, ISA, LG, ML, OA and PG are used for butyl stearate, N,N-dimethyldodecylamine-N-oxide, diethylene glycol monoethyl ether, diisopropyl adipate, ethyl oleate, glyceryl monolaurate, isopropyl myristate, isostearic acid, lauryl glycol, methyl laurate, oleyl alcohol and propylene glycol respectively. The abbreviation LN is used for levonorgestrel.

-24- Example 1 Copolymer (50 g of 54/36/10 IOA/HEA/PSMac, 41% solids in 95/5 ethyl acetate/isopropanol, inherent viscosity 0.75 dVg) and isopropyl myristate (1.08 g) were combined in a glass jar. The jar was capped and placed on a roller for about 24 hours. The resulting formulation was knife coated at a wet thickness of 12 mil (305 pM) onto a silicone release liner [5 mil (127 pM) Daubert PESTER].

The coated release liner was oven dried at 110 0 F (43 C) for 4 minutes then at 180F (82 0 C) for 4 minutes. The resulting coating contained 95 percent 54/36/10 IOA/HEA/PSMac copolymer and 5 percent isopropyl myristate. The coated liner was laminated to the corona treated side ofa 3 mil (76 pM) polyethylene film. The I' compliance was measured using the test method described above and found to be 0.42 X 10 cm 2 /dyne (average of three independent determinations).

Examples 2- 33 Using the general method of Example 1, a series of coated sheet materials in which the copolymer, softener and amount of softener were varied was prepared.

The copolymer, identity and amount of softener, wet coating thickness, and the compliance values are shown in Table 1. Unless otherwise indicated, each J-value is the average of three independent determinations. When the compliance was "not run", the formulation was too soft to be tested.

i e Table I Example Copolymer Softener Wet Coating i-value Number Thickness (X 10-1 (milviM) cm 2 f/dynej) Type iv (du/g) 2 54/36/10 IOAA-IEA/PSMac 0.75 10% 1PM 12/305 0.57 3 54/36/10 IOA/HEAIPSMac, 0.75 13% 1PM 12/305 0.57 4 5436/10 IOAII-EAIPSMac 0.75 17% 1PM 10/254 0.80 54/36/10 IOAIHEA/PSMac 0.75 20% 1PM 10/254 1.12 6 54/36/10 IOAIHEAIPSMac 0.75 25% IPM 8/203 2.26 7 54/36/10 IOAIHIEAIPSMac 0.29 5% 1PM 12/305 1.09 8 54/36/10 IOA/HEA/PSMac 0.29 10% 1PM 12/305 1.65 9 54/36/10 IOAIHEA/PSMac 0.29 13% 1PM 12/305 1.83 54/36/10 [OA/HEA/PSMac 0.29 17% IPM 10/254 2.13' Table I Example Copolymer Softener Wet Coating J-value Number Thickness (X 1 0- (mi/LIVM) cm.

2 /dyne) Type iv (dl/g) 11 54/36/10 IOA/HEAIPSMac 0.29 20% 1PM 10/254 3.87 2 12 54/36/10 IOAIHEA/PSMac, 0.29 25% 1PM 8/203 14.2 13 5 1/34/15 IOAIHEA/PM4MAMac 0.38 10% 1PM 12/305 0.28 14 5 1/34/15 IOAIHEAIPM4MAMac 0.38 20% [PM 10/254 0.46 5 1/34/15 IOA/HEAIPMMALac* 0.42 10% 1PM 12/305 0.28 16 5 1/34/15 IOAIHEA/PMMNAMac* 0.42 20% IPM 10/254 0.38 17 72/13/15 IOAIHEA/PNMA ac 0.36 10% 1PM 12/305 0.38 18 72/13/15 I0A/HiEAIPMMAMac 0.36 20% IPM 10/254 0.53 19 85115 IOA/PMMfvAMac 0.48 10% 1PM 12/305 not run p p p p p *p *p Table I Example Copolymier Softener Wet Coating 1-value Number Thickness (X I O" (miV/iM) cm 2 /dyne) Type iv (dVg) 85/15 IOA/PMMAAMac 0.48 20% 1PM 10/254 off scale C 1 57/38/5 IQA/HEA/PSMac 0.32 none 6/152 1.29 21 54/36/10 IOA/HEAIPSMac 0.29 30% IPM 6/152 66.8 22 5 1/34/15 IOAIHBAIPSMac 0.28 30% 1PM 6/152 18.2 23 5 1134/15 IOAIH-EA/PSMac 0.28 15% 1PM 10/254 0.76 C2 57/38/5 IOAIH-EA/PSMac 0.65 none 6/152 0.57 24 54/36/10 IQA/HEAIPSMac 0.75 35% 1PM 6/152 11.2 51/34/15 IQA/fHBAIPSMac 0.73 50% 1PM 6/152 155 26 5 1/34/15 IOA!HEAIPSMac 0. 73 40%/ 1PM 6/152 27.8 S S S S S S S S S S S S *5 *S Table I Example Copolymer Softener Wet Coating I-value Number Thickness (X 105 (mu/PM) CM 2 /dyne) Type iv (dl/g) 27 5 1/34/15 IOA/HEA/PSMac 0.73 30% IPM 6/152 2.36 28 5 1/34/15 IOA/HEA/PSMac 0.73 50% OA 10/254 not run 29 51/34/15 IOAIHEAIPSMac 0.73 40% OA 10/254 3.59 5 1/34/15 IQAIHEA/PSMac 0.73 30% OA 10/254 0.64 31 5 1/34/15 IOA/1-EAIPSMac 0.73 20% OA 10/254 0.42 32 5 1/34/15 IOA/HEAIPSMac 0.73 40% ISA 10/254 0.79 33 51/34115I1OAIHEAIPSMac 0.73 40% BS 10/254 not run 'average of 2 determinations 2aeaeof 4 determinations PMA~ac* ELVACITE 1020 Examples 34 38 Using the general method of Example 1, a series of coated sheet materials in which the copolymer was varied but the amount of IPM was theoretically held constant was prepared. The copolymer and amount (both calculated and determined using a modification of the method described above) of IPM, wet coating thickness, and the compliance values are shown in Table 2. In the modified analysis procedure, sample preparation involved combining 2 mL ethyl acetate containing 0.05 mg/mL lauryl acrylate with 25 mg of polymer. In the modified analysis procedure, isopropyl myristate standards did not contain copolymer.

Unless otherwise indicated, each J-value is the average of three independent determinations.

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*5 S S S S S S S S S S S S 5 S S S 55 5.

Table 2 Examle opoyme WtPerent1PM Wet Coating I-value N u m b eC p l m rW e c n P T hickness (X I 0 Nubr(mil/pM) cm 2 /dyne) Type iv Caic. Actual (d~g) 34 78/14/8 IOA/HE-A/PSMac 1.60' 20 13.5 10/254 1.68' 78/14/8 IOAIHEAIPSMac 1.07' 20 11.7 10/254 3.86 36 95/5 IOAIPSMac 0.47 20 12.5 10/254 12.8 37 55/40/5 IOA/HEA/PSMac 0.38 20 13.4 10/254 19.7 38 55/40/5 IOAIHEA/PMMAMac 0.34 20 10.5 10/254 10.3 'Run in tetrahydrof'uran 2 Average of 4 determinations Example 39 Copolymer (50 g of 51/34/15 IOA/HEA/PSMac, 39.2% solids in 95/5 ethyl acetate/isopropanol, iv 0.73 dlg) and oleyl alcohol (8.4 g) were combined in a glass jar. The jar was capped and placed on a roller for about 24 hours. The resulting formulation was knife coated at a wet thickness of 15 mil (381 pM) onto a silicone release liner [5 mil (127 pM) Daubert PESTER]. The coated release liner was oven dried at 110 0 F (43 C) for 20 minutes. The resulting coating theoretically contained 70 percent 51/34/15 IOA/HEA/PSMac copolymer and 30 percent oleyl alcohol. The coated liner was laminated to a backing (1109 SCOTCHPAK M tan, polyester film laminate, available from the 3M Company). The compliance was measured using the test method described above and found to be 0.74 X 10' S: cm 2 /dyne (average of three independent determinations). A portion of the coating o e was removed from the backing and assayed for oleyl alcohol using the test method described above. The oleyl alcohol content was found to be 28 percent.

Examples 40 106 Using the general method of Example 39, a series of coated sheet materials in which the copolymer, softener and amount of softener were varied was prepared.

The copolymer, identity and amount (weight percent, both calculated and 20 determined using the methods described above) of softener, wet coating thickness, and the compliance values are shown in Table 3. Unless otherwise indicated, each J-value is the average of three independent determinations.

0 0** 0 0 0 0*0 000 0 9 0 ~0* 9 0 0* 0** 0 000 0 0** 0@ 0 0 0 00 0 0 0 *o Table 3 Example Copolymer Softener Wet Coating J-value Number Thickness (X 10-1 (ml VA~M) cm 2 /dyn Type iv ID Caic Actual (d~g) C3 57/38/5 IOA/HEA/PSMac 0.65 None 0 0 15/38 1 0.92' 57/38/5 IOA/HEA/PSMac 0.65 OA 10 8.9 15/38 1 2.05 41 57/38/5 IOA!HEA/PSMac 0.65 OA 20 19.9 15/381 3.39 42 57/38/S IOAIHEA/PSMac 0.65 OA 30 29.7 15/381 4.29 C4 95/5 IOAIPSMac 0.45 none 0 0 15/381 3.22 43 95/5 IOAIPSMac 0.45 OA 20 18.9 15/38 1 5.00 44 95/5 IOAIPSMac 0.45 OA 40 37.1 15/381 8.16 90/10OIOAIPSMac 0.65- none 00 15/381 1.07

S

0000 0 S *0e *5* 0 0*@ 0e 0 6 @05 000 0 0600 S 0 S 0

S.

0SS 0 @00 0 0@ 0e@O S @0 0 S S 0005 5 @0 SOSe S 0 500 0 0 00 55 Table 3 Example Copolymer Softener Wet Coating J-value Number Thickness (X1,- (miV PM) cm.

2 /dyne)' Type iv ID) Caic Actual (dl/g) 90/10 IOA/PSMac 0.65 OA 20 18.8 15/381 1.63 46 90/10 IOA/PSMac 0.65 OA 40 39 15/381 2.72 C6 85/15 IOAIPSMac 0.55 none 0 0 15/381 -0.56 47 85/15 IQA/PSMac 0.55 OA 20 19 15/381 0.85 48 85/15 IOAIPSMac 0.55 OA 40 36 15/381 1.74 49 57/38/5 IOAIHEFAIPSMac 0.65 OA 40 37 15/381 4.99 57/38/5 IOAII-EAIPSMac 0.65 OA 60 56.5 15/381 22 12 51 57/38/5 IOAIHEAIPSMac; 0.65 OA 60 4/102 1300' 52 95/5 IOA/PSMac 0.45 OA 40 36.7 15/381 9.88 Table 3 Example Copolymer Softener Wet Coating J-value Number Thickness (X (miVlPM) cm 2 /dyne) Type iv DD Caic Actual (d~g) 53 95/5 IGA/PSMac 0.45 OA 60 52.8 15/381 not run 54 95/5 IGA/PSMac 0.45 OA 60 4/102 not run 90/10 IOA/PSMac 0.65 GA 40 38 15/381 2.95 56 90/10 IGA/PSMac 0.65 GA 60 56.6 15/381 not run 57 90/10 IOAJPSMac 0.65 GA 60 4/102 4.12' 58 85/15 IOA/PSMac 0.55 GA 40 40.5 15/381 1.99 59 85/15 IOAIPSMac 0.55 GA 60 60 15/381 48.22 85/15 [OAIPSMac 0.55 OA 60 4/102 2.82' C7 54/36/10 IOA/HEA/PSMac 0.54 none 0 0 15/381 0.51 9 *9 9 9 9 9.

Table 3 Example Copolymer Softener Wet Coating J-value Number Thickness (X 1-1 (milIPM) cm 2 /dyne) Type iv ED Caic Actual (d~g) 61 54/36/10 IOAIHEAIPSMac 0.54 OA 10 9.1 15/381 0.83 62 54/36/10 IOAII-EAIPSMac 0.54 OA 20 18.3 15/381 1.18 63 54/36/10 IOAlHEAIPSMac 0.54 OA 30 28.1 15/381 1.63 64 54/36/10 IOA/HEFAIPSMac 0.54 OA 40 37.6 15/381 2.32 6554/36/10 IOAIHEAIPSMac 0.54 OA 60 56.9 15/381 66 54/36/10 IOAIHEAIPSMac 0.54 OA 60 4/102 230' 67 95/5 IOAIPSMac 0.45 OA 47 45.5 15/381 40.52 68 90/10 IOA/PSMac 0.65 OA 47 48 15/381 3.34 69 90/10 IOA/PSMac 0.65 OA 53 53.5 15/381 6.26' Table 3 Example Copolymer Softener Wet Coating J-value Number Thickness (X 10-1 (ril/lgM) cm 2 dyne) Type iv EID Caic Actual (dUg) 90/10 IOAIPSMac 0.65 OA 53 4/102 4.43' 71 85/15 IOAIPSMac 0.55 OA 47 42.2 151381 15.i1' 72 85/15 IOAIPSMac 0.55 OA 53 50.7 151381 27.03 73 57/38/5 IQAJHEAIPMMVAMac* 0.53 1PM 20 19.2 15/381 2.34' 74 57/38/5 IOA/HEA/PMMAMac* 0.53 1PM 40 39.3 15/381 34.4 54/36/10 IOAIHEA/PMMAMac* 0.46 1PM 20 19.6 15/381 0.79 76 54/36/10 IOA./HEA/PNiMA~ac* 0.46 rpm 40 38.5 15/381 93.37 C8 51/34/15 IOA/HEAIPMMA~ac* 0.35 None 0 0 15/38 1 0.42 7751/34/15 IOA/HEA/PMMAAMac* 0.5 1M 10 9.6 15/381 0.83'

S.

S S S S S 55 Table 3 Example Copolymer Softener Wet Coating J-value Number Thickness (X 1 0- (ITiVJIM) cm 2 /dyne) Type iv ID Caic Actual (dI/g) 78 5 1/34/15 IOA/HEA/PMMAMac* 0.35 1PM 20 18.7 15/381 1. 18' 79 51/34/1510OA/HEAIPMMAMac* 0.35 1PM 30 27.2 15/381 1.52' 5 1/34/15 1OA/1HEAIPMMAMac* 0.35 1PM 40 36.6 15/381 334 2 81 51/34/15 IOA/HEAIPMMAMac* 0.35 1PM 50 42.1 4/102 4.46' 82 5 1/34/15 IQAIHEA/PMMAMac* 0.35 1PM 60 45.2 4/102 4.26' 83 51/34/15 1OA/IHEA/PMNA~ac* 0.35 OA 10 9.7 15/381 0.6 13 84 51/34/15 IOAIIHEAIPMMENAMac* 0.35 GA 20 19.3 15/381 0.94' 5 1/34/15 IOA/HEAIPMMAMac* 0.35 GA 30 30.5 15/38 1 1.22 3 86 5 1/34/15 ioA/HEAIPMMAAMac* 0.35 OA 40 40.3 15/381 1.77 3 Table 3 Example Copolymer Softener Wet Coating J-value Number Thickness (X 1-1 (ntiVpM) cm 2 /dyne) Type iv ID Caic Actual (dVg) 87 5 1/34/15 IGA/HEA/PMMAiac* 0.35 GA 50 48.7 15/38 1 2.43' 88 51/34/15 IOAHEA/PMM4AMac* 0.35 GA 60 58.6 15/381 3.69' 89 5 1/34/15 IOAIHEAIPMMA~ac* 0.35 OA 60 60.1 4/102 4.03 2 57/38/5 IOAIHEAIPSMac 0.65 OA 47 46.3 15/381 9.86 91 57/38/5 IOAIHBEAIPSMac 0.65 GA 47 4/102- 36.3' 92 57/38/5 IOAIH-EAIPSMac 0.65 GA 53 52.3 15/381 47.2 93 57/38/5 IOAIHEAIPSMac 0.65 OA 53 4/102 2.87 2 94 54/36/10 IOAIHEA/PSMac 0.56 GA 47 46 15/38 1 2.99 54/36/10 IOALHEA/PSMac 0.56 GA 47 4/102 3.62' 0 0 000 0..

a a a a a a a.

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a a a a a a a a a a a a a a a a *a Table 3 Example Copolymer Softener Wet Coating J-value Number Thickness M2 1 o-1 (mi~pM) cm/dyne) Type iv II) Caic Actual (dVg) 96 54/36/10 IOA/HE-A/PSMac 0.56 OA 53 51 15/381 19.1 97 54/36/10 IOAIHEA/PSMac 0.56 OA 53 4/102 125' C9 5 1/34/15 IOAIHEAIPSMac 0.52 none 0 0 15/381 0.36 98 51/34/15 IOAIHBAIPSMac 0.52 OA 10 10 15/381 0.50 99 S51/34/15 IOAIHE-A/PSMac 0.52 OA 20 19.7 15/381 0.56 100 5 1/34/15 IOA/HIEAIPSMac 0.52 OA 30 30.4 15/381 0.77' 101 5 1/34/15 IOAIHE-AIPSMac 0.52 OA 40 40.5 15/381 1.16 102 51/34/15 I0A/HEA/PSMac 0.52 OA 47 48.1 15/381 1.56 103 51/34/15 IOAIEAIPSMac 0.52 OA 47 4/102 1.81, Table 3 Example Copolymner Softener Wet Coating ]-value Number Thickness (X I-0-1 (il/I/ cm 2 ldyne) Type iv ID Caic Actual (dug) 104 5 1/34/15 IOAIHEA/PSMac 0.52 OA 53 53.9 15/381 33.7 105 5 1/34/15 IOAII-EAIPSMac 0.52 OA 53 4/102 4.04 2 106 51/34/15 IOAIHEAIPSMac 0.52 OA 60 61 15/381 147 2 'Average of four determinations 2 Single determination 3'Average of two determinations PMIMAMac* is ELVACITE 1020 Examples 107- 129 Using.the general method of Example 39, a series of coated sheet materials in which the copolymer, softener and amount of softener were varied was prepared.

The copolymer, identity and amount (weight percent) of softener, wet coating thickness, and the compliance values are shown in Table 4. Unless otherwise indicated, each J-value is the average of two independent determinations. When the compliance was "not run", the formulation was too soft to be tested.

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a a a a a p a 0Oe a., a a a. a af a 0 *4 9 a a a a a* a a a a a a a 0* 0.

Table 4 Example Copolymer Softener Wet Coating J-value Number Thickness (X (mul/pM) cm 2 /dyne Type iv (dI/g) CIO 57/38/5 IOA/HEA/PMMAMac* 0.54 none 15/381 0.80' 107 57/38/5 IQAIHEA/PMMQAMac* 0.54 10% 1PM 4 15/38 1 1.50 108 57138/5 1OAIH~EA/PMMAAMac* 0.54 20% 1pM 4 15/38 1 2.62 109 57/38/5 IOA/HEA/PMM4AMac* 0.54 30% 1PM 4 15/38 1 4.58 110 57/38/5 IOAIHEAIPMMAMac* 0.54 40% 1PM 4 4/102 64.2 2 111 57/38/5 IOA/HEA!PMIMAMac* 0.54 50% 1PM 4/102 not run 112 57/38/15 1OAf1HEA/PNMAMac* 0.54 60% 1PM 4/102 not run C11 54/36/10 IOA/HEA/PMMfvAMac* 0.50 none 15/381 0.44 S S Table 4 Example Copolymer Softener Wet Coating ]-value Number Thickness (X I 0" (mit/pM) cm 2 /dyne Type iv (dVg) 1 13 54/36/10 1QA/H~EA/PMfMAMac* 0.50 10% IPM 4 15/381 0.69 114 54/36/10 IOAIHiEAIPMiMAMac* 0.50 20% 1PM 4 15/381 0.94' 115 54/36/10 IOA/HIEAIPMMAMac* 0.50 30% 1PM 4 15/38 1 1.46 116 54/36/10 IOAIEAIPMMfAMac* 0.50 40% 1PM 4/102 not run 117 54/36/10 IOAIH~EAIPMMAMac* 0.50 50% 1PM 4/102. not run 118 57/38/5 IOAIIHEA/PMIMA~ac* 0.54 10% OA -15/381 1.63 119 57/38/5 IOAIHEA/PMMvAMac* 0.54 20% OA 15/381 2.70 120 57/38/5 IOAI1HEA/PMMvAMac* 0.54 30% OA 15/38 1 4.19 121 57/38/5 LOAIHEA!PMiMAMac* 0.54 40% OA 4/102 6.01 Table 4 Example Copolymer Softener Wet Coating I-value Number Thickness (X 101 (miVA~M) cm 2 /dyrie Type iv (dVg) 122 57/38/5 IOA/HEA/PMM4AMac* 0.54 50%/oOA 4/102 8.27 123 57/38/5 IOA/HEA/PMM4AMac* 0.54 60% OA 4/102 11.8 124 54/36/10OIOA/HBAIPMMA~ac* 0.50 10% OA 15/381 0.60 125 54/36/10 1OA/HE1AIPMA~ac* 0.50 20% OA 15/381 0.89 126 54/36/10 IOAIHEAIPMMAMac* 0.50 30% OA 15/381. 1.19 127 54/36/10 IOAIHEAIPMfMAMac* 0.50 40% OA 4/102 1.56 128 54/36/10 IOAIHEAIPM4MAMac* 0.50 50% OA 4/102 2.65 129 54/36/10 IOAIHEAIPMUVIAac* 0.50 60% OA 4/102 3.99 PNM*c is ELACT 1020. 'Aerg of fou determinations*. 3 Average of for determinations '1PM content confirmed using the test method described above.

Example 130 Copolymer (6.7306 g of 63/27/10 IOA/DMACM/PMMAMac, 47.8% solids in 95/5 w/w ethyl acetate/isopropanol, iv 0.39 dlg), levonorgestrel (0.0502 g) and methyl laurate (1.7606 g) were combined in an 11 dram (40.7 mL) glass vial.

The vial was capped then shaken overnight on a platform shaker. The resulting formulation was knife coated at a thickness of 16 mil (406 pm) onto a release liner (Daubert 164Z 5 mil [127 gM] PESTER). The coated release liner was oven dried for 4 minutes at 125 0 F (52 0 for 2 minutes at 185°F (85 0 C) and for 2 minutes at 225"F (107°C). The resulting adhesive coating contained 64.0 percent 63/27/10 IOA/HEA/PMMAMac copolymer, 1.0 percent levonorgestrel and 35.0 percent methyl laurate. The coated liner was then laminated onto the corona treated surface of a 3 mil (76.2 pm) polyethylene backing. The compliance was measured using the test method described above and found to be 4.4 X 10-' cm 2 /dyne.

15 Examples 131 178 Using the general method of Example 130, a number of coated sheet materials were prepared in order to assess the effect of increasing the amount of skin penetration enhancer(s) on the compliance of certain formulations containing levonorgestrel. The compliance was measured using the test method described 20 above. The formulations and the J-values are shown in Table 5, where amounts are percent by weight. Except as noted, the polymethylmethacrylate macromonomer was ELVACITE 1010. PMMAMac* indicates that the polymethylmethacrylate was ELVACITE 1020.

C Table ExAdhesive LN GM DDA Additional J-Value No. L 0 Enhancer(s) (cm 2 /dyne) Amount Type iv 131 68.7 63/27/10 1.0 0 0 30.3 ML 2.4 x IOAIDMACM/PMMvAMac 132 74.2 63/27/10 1.0 0 0 24.8 ML 2.1 x10* IOA/DMACMIPMM4AMac 133 64.5 55/40/5 1.0 0 0 17.1 DGME off scale IOA/HEA/PMMAAMac 17.4 LG 134 68.7 55/40/5 1.0 0 0 15.2 DGME 15.4 x IOAIHEAIPMMvAMac 15.1 LG 135 74.0 55/40/5 1.0 0 0 12.6 DGME 5.2 x IOA/HEAIPMMdAMac 12.4 LG Table Ex Adhesive LN GM DDA Additional J-Value No. L 0 Enhancer(s) (cm 2 /dyne) Amount Type iv 136 78.9 55/40/5 1.0 0 0 10. 1 DGMIE 5.0Ox IOAIHBAIPMMfAMac 10.0OLG 137 65.7 55/40/5 0.51 1.0 5.0 3.0 12.8 DGME 2.6 x IOA/HEAIPMMAAMac 12.5 LO 138 60.9 55/40/5 0.51 1.0 5.0 3.0 15.0ODGME 2.9 x IOAIHEAIPMMA~ac 15.1 LG 139 55.8 55/40/5 0.51 1.0 5.0 3.0 17.6 DGME 3.4 x IOAIHEAIPMMVAMac 17.6 LG 51.1 5514015 0.51 1.0 5.0 3.0 20.0ODGME 8.1 x 0-' IOAIHEAIPMMvAMac 19.9 LG 141 65.4 55/35/10 0.42 1.0 4.9 3.1 12.7 DGME 2.2 x IOA/HEAIPMlMAMac 12.9 LG *q a.

a a a Table Ex Adhesive LN GM DDA Additional J-Value No. L 0 Enhancer(s) (cm 2 /dyne) Amount Type iv 142 60.5 55/35/10 0.42 1.0 4.9 3.0 15.4 DGME 1.9 x 101 IOAIHEAIPMMAtac 15.2 LG 143 55.7 55/35/10 0.42 1.0 5.2 3.0 17.6 DGMB 2.2 x IOAII-EAIPMMALac 17.5 LG 144 50.7 55/35/10 0.42 1.1 5.0 2.9 20.0 DGME 2.8 x IOAIHEAIPMMALac 20.3 LG 145 65.4 55/35/10 0.46 1.0 4.9 3.0 13.1 DGMIE 1.5 x IOA/HIEAIPMMfvAMac 12.6 LG 146 60.7 55/35/10 0.46 1.1 5.4 3.0 15.0ODGME 1.8 x 10O1 [OAIHEA[PMMYAMac* 14.8 LG 147 56.0 55/35/10 0.46 1.0 5.0 3.0 17.5 DGME 2.2 x IOAIHIEAJPMMAAMac* 1 17.5 LG Table Ex Adhesive LN GM DDA Additional J-Value No. L 0 Enhancer(s) (cm 2 ldyne) Amount Type iv 148 50.7 55/35/10 0.46 1.1 5.0 3.0 20.0 DGMIE 2.4 x IOA/HEA/PfMAac* 20.2 LG 149 52.9 63/27/10 0.48 1.0 5.1 1.0 40.0 ML 17.4 x IOA/DMACMIPMM4AMac 150 58.0 63/27/10 0.48 1.0 5.1 1.0 34.9 ML 9.5 x IOAIDMACMIPMfMAMac 151 63.1 63/27/10 0.48 1.0 5.0 1.0 29.9 ML 4.0 x IOA/DMACMIPMMAAMac 152 67.8 63/27/10 0.48 1.0 5.1 1.1 25.0OML 3.7 IOA/DMACMIPMMIAMac 153 72.9 63/27/10 0.48 1.0 5.0 1.0 20.1 ML 2.2 x 10Y IOA/DMACM/PMMfvAMac 9 9** 9** 9 9** 9 9 9* 9 9* 9* 9** 9 9 9* 9e*e *9 9 9 9 .9 *9 Table Ex Adhesive LN GM DDA Additional J-Value No. L 0 Enhancer(s) (cm 2 /ldyne) Amount Type iv 154 70.6 55/40/5 0.51 1.0 5.0 3.0 10.3 PG 3.3 x 1- IQA/HEAIPMMA~ac 110.1 ML 155 65.0 55/40/S 0.51 1.0 5.1 3.0 12.3 PG 3.1 xlO0- IOAIHEA/PMMAAMac 13.6 ML 156 60.5 55/40/5 0.51 1.0 5.0 3.1 15.3 PG 4.9 IOA/HEAIPMMAAMac 15.1 ML 157 55.7 55/40/5 0.51 1.0 5.1 3.0 17.7 PG 5.3 x [OA/HEA!PMAMac 17.5 ML 158 51.0 55/40/5 0.51 1.0 5.0 3.0 20.2 PG 3.4 IOAIHEAIPMMA"ac 19.8 ML 159 69.8 55/35/10 0.42 1.0 5.2 3.0 10.0 PG 1.4 x IOAIHEA/PMMAAMac 11.0 NS a a a. a a a a a a a..

a a. a a. a a a a a a aa a a. a a a Table Ex Adhesive LN GM DDA Additional J-Value No. L 0 Enhancer(s) (cm 2 e/dyne) Amount Type iv 160 66.1 55/35/10 0.42 1.0 4.9 3.0 12.3 PG 1.4 IOA/HEA/PMMAMac 12.7 ML 161 60.7 55/35/10 0.42 1.0 5.0 3.0 15.3 PG 2.0 x IOA/HEAIPMMYAMac 15.0 ML 162 55.8 55/35/10 0.42 1.0 5.0 3.0 17.7 PG 2.3 x10- IOA/HEAIPMM4AMac 17.5 ML 163 50.7 55/35/10 0.42 1.0 5.3 3.0 20.2 PG 2.7 x IOAIHEA/PMMAMac 19.8 MIL 164 72.0 60/15/15/10 0.47 1.0 5.0 2.0 14.3 M1L 2.0Ox IOA/DMACM/HIEA/PMMA~ac 5.7 DIPA 165 67.3 60/15/15/10 0.47 1.0 5.0 2.1 17.8 ML 2.4 x IOA/DMACM/HEA/PMMAt~Mac 6.8 DIMA p p*.

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p p p p p p p pp p p p p p* Table Ex Adhesive LN GM DDA Additional J-Value No. L 0 Enhancer(s) (cm 2 /dyne) Amount Type iv 166 61.7 60/15/15/10 0.47 1.0 5.0 2.1 21.8 ML 5.0 IOA/DMACM/HEA/PMM4AMac 8.4 DEPA 167 56.9 60/15/15/10 0.47 1.0 5.1 2.0 25.4 ML 7.8 x 1- IOAIDMACMTHEAIPMMAMac 9.6 DIPA 168 52.0 60/1 5/15/10 0.47 1.0 5.2 2.0 28.8 ML 16.6 x 1- IOAIDMACM/HEAJPMMAAMac 11.0 DEPA 169 72.7 68/27/5 0.47 1.0 5.0 1.0 20.3 ML 15.4 IOA/DMACMIPMMAMac 170 68.0 68/27/5 0.47 1.0 5.0 1.1 24.9 ML 24.8 x IOA/DMACMIPMMvAMac 11 72.2 50/40/10 0.53 1.0 4.9 1.0 20.9 ML 1.8 x 1o-s IOAJDMACM/PMMAMac

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I OCOC C C SC. S CS S* Table Ex Adhesive LN GM DDA Additional J-Value No. L 0 Enhancer(s) (cm 2 /dyne) Amount Type iv 172 67.7 50/40/10 0.53 1.0 5.0 1.0 25.3 ML 2.7 x IOAIDMACM/PMMAAMac1 173 63.5 50/40/10 0.53 1.0 4.9 1.0 29.6 NE 5.2 x IOAIDMACM/PMIMAMac 174 58.3 50/40/10 0.53 1.1 5.0 1.1 34.5 ML 10.7 x IOAIDMACMIPMMAMac 175 53.0 50/40/10 0.53 1.0 5.1 1.1 39.8MNIL 21.5 IOA/DMACMIPMMAMac 176 71.0 65/15/15/5 0.47 1.0 5.0 2.0 13.7 ML 8.8 x10-1 IOA/DMACM/HEA/PMMAMac 7.3 DIPA 177 66.7 65/15/15/5 0.47 1.0 5.1 2.0 17.5 NE 13.2 x IOAIDMACMIHEA/PMMA~ac 7.7 DIPA S Table Ex Adhesive LN GM DDA Additional J-Value No. L 0 Enhancer(s) (cm 2 /dyne) Amount Type iv 178 62.6 65/15/15/5 0.47 1.0 5.1 2.0 20.3 MLf 22.9 x i0-' IOA/DMACM/1-IA/PMMAAMac 9.0 DIPA In Vitro Skin Penetration Test Method The skin penetration data given in the examples below was obtained using the following test method. A Diffusion cell 20 of the type shown in Figure 1 is used. Human cadaver skin (Dermatomed skin about 5001M thick obtained from a skin bank) is used. A shown in Figure 2, the skin 22 is mounted epidermal side up between upper portion 24 and lower portion 26 of the cell, which are held together by means of ball joint clamp 28.

The portion of the cell below the mounted skin is completely filled with receptor fluid (30% N-methyl-2-pyrrolidone in water) such that the receptor fluid is S in contact with the skin. The receptor fluid is stirred using a magnetic stirrer (not illustrated). The sampling port 30 is covered except when in use.

When a transdermal delivery device is evaluated, the skin is placed across the orifice of the lower portion of the diffusion cell, the release liner is removed from a 2.0 cm 2 patch and the patch is applied to the skin and pressed to cause uniform contact with the skin. The diffusion cell is assembled and the lower portion o.

is filled with 10 mL of warm (32 0 C) receptor fluid.

The cell is the placed in a constant temperature (32 2 0 C) and humidity 10 relative humidity) chamber. The receptor fluid is stirred by means of a magnetic stirrer throughout the experiment to assure a uniform sample and a reduced diffusion barrier on the dermal side of the skin. The entire volume of receptor fluid is withdrawn at specified time intervals 12, 24, 48 and 72 hours) and immediately replaced with fresh fluid. The withdrawn fluid is filtered through a 0.45 pM filter. A 1 mL portion of filtrate is then analyzed for levonorgestrel using high performance liquid chromatography (Column: 15 cm X 4.6 mm I.D.

ZORBAX

T M RX-C18 from DuPont, 5 pM particle size; Mobile Phase: 60/40 v/v water/acetonitrile; Flow Rate: 1.5 mL/min; Run Time: 11.0 min; Detection: uv at 230 nm). The cumulative amount of levonorgestrel penetrating the skin is calculated. The greatest slope of a plot of the cumulative penetration versus time is reported as steady state levonorgestrel flux measured in ug/cm 2 /hour.

-57- Example 179 Levonorgestrel (19.85 methyl laurate (330.8 propylene glycol (198.5 glyceryl monolaurate (33.08 N,N-dimethyldodecylamine-N-oxide (19.85 g) and copolymer (1803 g of 55/40/5 IOA/HEA/PMMAMac copolymer, 40% solids in 95/5 w/w ethyl acetate/isopropanol, which had been dried then resolvated, iv 0.59 dl/g after drying) were placed in a 1 gallon (3.8 L) high density polyethylene carboy.

The carboy was tightly capped then placed on a roller/shaker for 19 hours. The carboy was allowed to stand until all entrapped air bubbles had dissipated. The resulting formulation was knife coated at a wet thickness of 16 mil (406 M) onto a silicone coated polyester (5 mil, 127 1tM) film. The coated release liner was oven dried at 127 0 F (53°C) for 30 minutes. The resulting adhesive coating contained percent levonorgestrel, 15.0 percent propylene glycol, 25.0 percent methyl laurate, 2.5 percent glyceryl monolaurate, 1.5 percent N,N-dimethyldodecylamine-N-oxide, and 54.5 percent 55/40/5 IOA/HEA/PMMAMac copolymer. The coated liner was allowed to cool for 10 minutes then it was laminated to the corona treated side of a 2 mil (51 pM) polypropylene film. The compliance was measured using the test method described above and found to be 6.57 X 10-' cm 2 /dynes. Skin penetration through human cadaver skin was measured using the test method described above; the steady state flux was found to be 0.166 gg/cm 2 /hr.

Example 180 SLevonorgestrel (18.29 methyl laurate (457.2 glyceryl monolaurate (65.31 N,N- dimethyldodecylamine-N-oxide (13.06 g) and copolymer (1401 g of 50/40/10 IOA/DMACM/PMMAMac copolymer, 53.7% solids in 95/5 w/w ethyl acetate/isopropanol, which had been dried then resolvated, iv 0.55 dlg before drying; iv 0.52 dl/g after drying) were placed in a 1 gallon (3.8 L) high density polyethylene carboy. The carboy was tightly capped then placed on a roller/shaker for 19 hours. The carboy was allowed to stand until all entrapped air bubbles had dissipated. The resulting formulation was knife coated at a wet thickness of 12 mil (305 uM) onto a silicone coated polyester (5 mil, 127 pM) film. The coated release liner was oven dried at 127 0 F (53 0 C) for 80 minutes. The resulting adhesive coating contained 1.4 percent levonorgestrel. 35.0 percent methyl laurate. percent glyceryl monolaurate, 1.0 percent N,N-dimethyldodecylamine-N-oxide, and 57.6 percent 50/40/10 IOA/DMACM/PMMAMac copolymer. The coated liner was allowed to cool for 10 minutes then it was laminated to the corona treated side of a 2 mil (51 pM) polypropylene film. The compliance was measured using the test method described above and found to be 5.74 X 10 cm 2 /dynes. Skin penetration through human cadaver skin was measured using the test method described above; the steady state flux was found to be 0.148 pg/cm 2 /hr.

10 Example 181 Levonorgestrel (18.04 methyl laurate (264.6 tetraglycol (96.23 g), glyceryl monolaurate (60.14 N,N-dimethyldodecylamine-N-oxide (12.03 g) and copolymer (1400 g of 50/40/10 IOA/DMACM/PMMAMac copolymer, 53.7% solids in 95/5 w/w ethyl acetate/isopropanol, which had been dried then resolvated, iv 0.55 dlg before drying; iv 0.52 dl/g after drying) were placed in a 1 gallon (3.8 L) high density polyethylene carboy. The carboy was tightly capped then placed on a roller/shaker for 19 hours. The carboy was allowed to stand until all entrapped air bubbles had dissipated. The resulting formulation was knife coated at a wet thickness of 13 mil (330 pM) onto a silicone coated polyester (5 mil, 127 tM) film. The coated release liner was oven dried at 127 0 F (53 0 C) for 75 minutes.

The resulting adhesive coating contained 1.5 percent levonorgestrel, 22.0 percent methyl laurate, 8.0 percent tetraglycol, 5.0 percent glyceryl monolaurate, percent N,N-dimethyldodecylamine-N-oxide, and 62.5 percent 50/40/10 IOA/DMACM/PMMAMac copolymer. The coated liner was allowed to cool for 10 minutes then it was laminated to the corona treated side of a 2 mil (51 pM) polypropylene film. The compliance was measured using the test method described above and found to be 8.72 X 10 cm 2 /dynes. Skin penetration through human cadaver skin was measured using the test method described above; the steady state flux was found to be 0.131 pg/cm 2 /hr.

Example 182 Copolymer (50.13 g of 57/38/5 IOA/HEA/PMMAMac, 39.5% solids in 97/3 ethyl acetate/isopropanol, iv 0.69 dlg) and nicotine (5.04 g) were combined in a glass jar. The jar was capped and shaken for 15 minutes. The resulting formulation was knife coated at a wet thickness of 8 mil (203 pM) onto a silicone coated polyester release liner (5 mil (127 pM) Daubert). The coated release liner was oven dried at 110°F (43°C) for 30 minutes. The resulting coating theoretically contained 79.71 percent 57/38/5 IOA/HEA/PMMAMac copolymer and 20.29 percent nicotine. The coated liner was laminated to a backing (1109

SCOTCHPAK

T tan, polyester film laminate, available from the 3M Company).

The compliance was measured 4 hours after the laminate was prepared using the test method described above and found to be 1.79 X 10s cm 2 /dyne. The compliance was measured again after the laminate had sat overnight and was found to be 1.5 X I 0' cm 2 /dyne (average of two independent determinations).

Example 183 The formulation prepared in Example 182 was knife coated at a wet thickness of 6 mil (152 pM) onto a silicone coated polyester release liner (5 mil (127 pM) Daubert). The coated release liner was allowed to dry at ambient 20 temperature (22 0 C) for 100 minutes. The resulting coating theoretically contained 79.71 percent 57/38/5 IOA/HEA/PMMAMac copolymer and 20.29 percent .i nicotine. The coated liner was laminated to a backing (1109 SCOTCHPAKT M tan, polyester film laminate, available from the 3M Company). The compliance was measured after the laminate had sat over the weekend and was found to be 2.4 X 10 cm'/dyne (average of two determinations).

Example 184 Copolymer (10.0 g of 55/9/28/8 2-ethylhexylacrylate/vinyl acetate/tetrahydrofirfuryl acrylate/ELVACITE 1020 PMMAMac 37.28 solids in 90/10 w/w ethyl acetate/isopropanol, iv 0.706 dl/g) and isopropyl myristate (0.93 g) were combined then mixed to provide a homogeneous formulation. The formulation was coated at a wet thickness of 15 mil (381 pM) onto a polyethylene terephthalate film then air dried to provide a pressure sensitive adhesive with clean release from skin.

Example 185 Copolymer (10.0 g of 55/9/28/8 2-ethylhexylacrylate/vinyl acetate/tetrahydrofirfuryl acrylate/ELVACITE 1020 PMMAMac 37.28 solids in 90/10 w/w ethyl acetate/isopropanol, 0.706 dl/g) and isopropyl myristate (1.60 g) were combined then mixed to provide a homogeneous formulation. The formulation was coated at a wet thickness of 15 mil (381 pM) onto a polyethylene terephthalate film then air dried to provide a pressure sensitive adhesive with clean release from skin.

Example 186 Copolymer (10.0 g of 82/10/8 IOA/2-hydroxyethyl methacrylate/ELVACITE 1020 PMMAMac 38.7% solids in 95/5 w/w ethyl acetate/isopropanol, iv 0.378 dl/g) and oleyl alcohol (0.97 g) were combined then mixed to provide a homogeneous formulation. The formulation was coated at a wet thickness of 15 mil (381 pM) onto a polyethylene terephthalate film then air 20 dried to provide a pressure sensitive adhesive with clean release from skin.

Example 187 Copolymer (10.0 g of 77/4/15/4 IOA/acrylamide/DMACM/ELVACITE 1020 PMMAMac 39.5% solids in 95/5 w/w ethyl acetate/isopropanol, iv 0.443 dl/g) and isopropyl myristate (0.99 g) were combined then mixed to provide a homogeneous formulation. The formulation was coated at a wet thickness of mil (381 pM) onto a polyethylene terephthalate film then air dried to provide an aggressive pressure sensitive adhesive with clean release from skin.

Example 188 Copolymer (10.0 g of 74/9/9/8 2-ethylhexyl acrylate/N-viny pyrroiidone/2hydroxyethyl acrylate/ELVACITE 1020 PMMAMac 39.4% solids in 95/5 w/w ethyl acetate/isopropanol, iv 0.365 dl/g) and isopropyl myristate (0.99 g) were combined then mixed to provide a homogeneous formulation. The formulation was coated at a wet thickness of 15 mil (381 pM) onto a polyethylene terephthalate film then air dried to provide an aggressive pressure sensitive adhesive with clean release from skin.

Example 189 Copolymer (10.0 g of 55/9/28/8 IOA/butyl methacrylate/ethoxy ethoxy ethyl acrylate/ELVACITE 1020 PMMAMac 38.3% solids in 95/5 w/w ethyl acetate/isopropanol, iv 0.78 dl/g) and oleyl alcohol (0.96 g) were combined then mixed to provide a homogeneous formulation. The formulation was coated at a wet thickness of 15 mil (381 pM) onto a polyethylene terephthalate film then air dried to provide a pressure sensitive adhesive with clean release from skin.

Example 190 Copolymer (10.0 g of 55/9/28/8 IOA/butyl methacrylate/ethoxy ethoxy ethyl 20 acrylate/ELVACITE 1020 PMMAMac 38.3% solids in 95/5 w/w ethyl acetate/isopropanol, iv 0.78 d/g) and oleyl alcohol (1.64 g) were combined then mixed to provide a homogeneous formulation. The formulation was coated at a wet thickness of 15 mil (381 pM) onto a polyethylene terephthalate film then air dried to provide a pressure sensitive adhesive with limited tack and with clean release from skin.

-62- Example 191 Copolymer (10.0 g of 55/9/28/8 IOA/butyl acrylate/ethoxy ethoxy ethyl acrylate/ELVACITE 1020 PMMAMac 38.5% solids in 95/5 w/w ethyl acetate/isopropanol, iv 0.78 dl/g) and oleyl alcohol (0.96 g) were combined then mixed to provide a homogeneous formulation. The formulation was coated at a wet thickness of 15 mil (381 pM) onto a polyethylene terephthalate film then air dried to provide a pressure sensitive adhesive with clean release from skin.

Example 192 Copolymer (10.0 g of 55/9/28/8 IOA/butyl acrylate/ethoxy ethoxy ethyl acrylate/ELVACITE 1020 PMMAMac 38.5% solids in 95/5 w/w ethyl acetate/isopropanol, iv 0.78 dl/g) and oleyl alcohol (1.65 g) were combined then mixed to provide a homogeneous formulation. The formulation was coated at a wet thickness of 15 mil (381 M) onto a polyethylene terephthalate film then air dried to provide a pressure sensitive adhesive with limited tack and with clean release from skin.

Example 193 Copolymer (100 g of 61/37/2 IOA/oAc/PSMac, 34 percent solids in 84/16 20 ethyl acetate/toluene, iv 0.87 dl/g) and oleyl alcohol (14.57 g) were combined in a glass jar. The jar was placed on a roller mixer overnight. The resulting formulation was knife coated at a wet thickness of about 7 mil (178 pM) onto a 2 il (51 pM) polyethylene terephthalate film. The coated film was oven dried at 110°F (43 C) for 20 minutes. The resulting coating theoretically contained percent 61/37/2 IOA/VoAc/PSMac copolymer and 30 percent oleyl alcohol. The coated film was folded back onto itself to form a "sandwich" and the compliance was measured using the test method described above. The compliance was found to be 6.8 X 10- 5 cm 2 /dyne (average of three independent determinations).

Examples 194 218 Using the general method of Example 193, a series of coated sheet materials in which the copolymer, softener and amount of softener were varied was prepared.

The copolymer, identity and amount (weight percent) ofsoftener, and the compliance values are shown in Table 6 where each J-value is the average of three independent determinations. The polymethylmethacrylate macromonomer used was ELVACITE 1020.

e -64- C ft ft C ft C ft.. C. ft ft ft ft ft ft S C ft ft ft* ft Table 6 Example Copolymer Softener J- value Number (X 10-5 cm 2 /dyrie) Type iv (du/g) C12 6 1137/2 IOA/VoAcIPSMac 0.87 none 1 194 61137/2 IOAIVoAcIPSMac 0.87 20% 1PM 15.7 195 6 1/37/2 IOA[VoAcJPSMac 0.87 30% 1PM 196 6 1/37/2 IOAIVoAcIPSMac 0.87 40% 1PM 197 61/37/2 IOAI~oAc/PSMac 0.87 40% OA C 13 61/37/2 IOAI~oAc/PSMac 1.02 none 0.65 198 6 1/37/2 IOAI~oAc/PSMac 1.02 20% 1PM 8.3 199 61/37/2 IOAI~oAc/PSMac 1.02 30% 1PM 17.6 200 61/37/2 IOAI~oAc/PSMac 1.02 40% 1PM 201 6 1/37/2 IOAI~oAc/PSMac 1.02 30% OA 3.2 202 6 1/37/2 IOA/VoAc/PSMac 1.02 40% OA C14 58/37/5 IOAI~oAcIPSMac 0.89 none 0.46 203 58/37/5 IOAI~oAc/PSMac 0.89 20% 1PM 2.3 204 58/37/5 IOA/VoAc/PSMac 0.89 30% 1PM 17.7 9 9 9 9 9 9 9 9 9 9* .99 9 9 9* 9 .9 9 9 *9 9 9 9 *9 Table 6 Example Copolymer Softener I- value Number (X 1 0's cm 2 /dyne) Type iv (dl/g) 205 58/37/5 IOAIVoAcIPSMac 0.89 40% 1PM 206 58/37/5 IOAf~oAc,'PSMac 0.89 30% OA 1.1 207 58/37/5 IOA/VoAc/PSMac 0.89 40% OA C1 5 58/37/5 IOAI~oAc/PSMac 1.02 none 0.44 208 58/37/5 IOA!VoAcIPSMac 1.02 20% 1PM 3.9 209 58/37/5 IOA/VoAc/PSMac 1.02 30% 1PM 11.2 210 58/37/5 IOAI~oAc/PSMac 1.02 40% UPM 211 58/37/5 IOAI~oAcIPSMac 1.02 30% OA 1.6 212 58/37/5 IOAJVoAcJPSMac 1.02 40% OA C 16 53/37/10 IOA/VoAc/PMMAtMac 0.815 none 0.15 213 53/37/10 IOA/VoAc/PMMvAMac 0.8 15 30% OA 0.32 C 17 53/37/10 IOAI~oAc/PMMAtMac 0.92 none 0.16 214 53/37/10 IOAI~oAcIPMMAMac 0.92 30% OA 0.36 C18 58/37/5 IOA/VoAc/PMMAAMac 1.05 none 0.4 Table 6 Example Copolymer Softener J- value Number (X 1 0- cm 2 /dyne) Type iv (dVg) 215 58/37/5 IOAIVoAcfPMMvAMac 1.05 30% OA 0.67 216 58/37/5 IOA/VoAcIPMMAMac 1.05 30% 1PM 0.71 c 19 58/37/5 IOAIVoAcIPMMAAMac 1.15 none 0.37 217 58/37/5 IOAIVoAc/PMMAMac 1.15 30% OA 0.7 218 58/37/5 IOA/VoAc/PMMfvAMac 1.15 30% 1IPM 0.8 Example 219 Copolymer (58/37/5 lOA/VoAc/PSMac, 34 percent solids in 84/16 ethyl acetate/toluene, iv 0.89 dl/g) was knife coated at a wet thickness of about 7 mil (178 pM) onto a 2 mil (51 tiM) polyethylene terephthalate film. The coated film was oven dried at 160 0 F (71°C) for 20 minutes and then at 210F (99 0 C) for minutes. Patches (5 cm 2 circles) each containing 0.044 g of dry adhesive were cut from the adhesive coated film. Nicotine (0.011 g) was placed on top of the adhesive in each patch using a micropipette to provide a patch with an adhesive layer containing 20 percent by weight of nicotine. The adhesive layer was covered with a release liner (SCOTCHPAKT m 1022) and allowed to equilibrate overnight.

The rate of release of nicotine from the patch was determined using the test method described below. The results are shown in Table 7 below where each entry is the average of three independent determinations.

Example 220 The method of Example 219 was repeated using a 58/37/5 IOA/VoAc/PSMac having an iv 1.02 dl/g. The rate of release of nicotine from the patch was determined using the test method described below. The results are shown in Table 7 below where each entry is the average of three independent 20 determinations.

In-vitro Release of Nicotine This method describes the dissolution test procedure used to evaluate invitro release characteristics of nicotine transdermal delivery patches.

The method uses a Hanson Dissolution Apparatus with the dissolution media temperature set at 32 0 C; the paddle speed set at 50 rpm; and the paddle height above the sample set at 25 mm.

Each patch (5 cm 2 is affixed with double sided adhesive tape to a separate stainless steel plate so that the release liner is facing upward (backing is in direct contact with the double sided tape). Each dissolution flask is charged with 500 mL -68- 0.1 M phosphate buffer (pH 6.0) and the temperature of the buffer is allowed to equilibrate at,32 0.5 0

C.

SThe release liner is removed from the patch and the mounted patch is placed in the dissolution flask. At 5, 10, 20, 30, 60, 90, 120, 240, 480 and 720 minutes, 4 mL samples are withdrawn and analyzed for nicotine content using uv sprectrophotometry with the wavelength set at 262 nm using a 1 cm flow through the spectrophotometer cell. The results are reported as the cumulative percent nicotine released.

Table 7 In-vitro Nicotine Release Time (minutes) Cumulative Percent Nicotine Released Example 219 Example 220 0 0 0 36.7 38.4 10 44.2 46.6 55.8 60.3 30 65.9 68.7 60 77.5 80.0 80.5 84.6 120 84.9 87.2 240 87.6 89.3 480 88.5 90.4 720 89.8 90.9 Example 221 Using the method of Example 219, patches having an adhesive layer containing 25 percent by weight of nicotine were prepared using a 53/37/10 IOA/VoAc/ELVACITE 1020 copolymer having an iv 0.92 dVg. The adhesive -69layer of the patch had many air bubbles. The compliance was found to be X 10' 3 cm2/dyne (average of three independent determinations).

Example 222 Using the method of Example 219, patches having an adhesive layer containing 25 percent by weight of nicotine were prepared using a 58/37/5 IOA/VoAc/ELVACITE 1020 copolymer having an iv 1.15 dlg. The compliance was found to be 0.9 X 10- 5 cm 2 /dyne (average of three independent determinations).

Example 223 Propylene glycol (1.52 methyl laurate (2.54 glyceryl monolaurate (0.25 N,N-dimethyldodecylamine-N-oxide (0.15 dried copolymer (5.53 g of 55/40/5 IOA/HEA/PMMAMac, iv 0.45 dlg prior to drying) and solvent (15 g of 95/5 w/w ethyl acetate/isopropanol) were combined and mixed to provide a homogeneous coating formulation. The formulation was coated at a wet thickness of 20 mil (508 pM) onto a silicone coated polyester release liner (Daubert PESTER). The coated release liner was oven dried for 4 minutes at 43 0 C, for 3 minutes at 85 0 C, and for 2 minutes at 107 0 C. The coated release liner was then laminated to the corona treated side of a clear 2 mil (51 uM) polypropylene film.

Patches (circular, 5 cm 2 were die cut from the resulting laminate. One patch was applied to the left forearm of a human subject. A second patch was applied to the right forearm of the same subject. The percent of patch surface adhering to skin was approximated by visual assessment through the clear backing. The results are shown in Table 8 below.

Examples 224 261 Using the general method of Example 223, a number of patches were prepared and the adhesion to skin evaluated in order to assess the effect of copolymer composition, copolymer inherent viscosity, wet coating thickness, softener composition and the amount of softener on adhesion to skin. The formulations (amounts are percent by weight) and adhesion evaluations are shown in Table 8 below wherein the absence of an entry indicates that the adhesion was not assessed at that time point, "OFF" means that the patch fell off by itself and "R" means that the patch was removed by the subject. All adhesion testing was conducted on the same subject and unless otherwise indicated the patch was adhered to the left forearm.

ao S 6 0 0 *0* 0 0** 0 ~0 0 ~0 0*0 ~0 0 0* *00 0 000 0 0* *e 0.@ 0 0 9 0*eO S 00 0 0 0 0 00 00 Table 8 Example Copolymner Softener Wet Coating Adhesion(% Number Thickness (miygM) Type iv DayO0 Day I Day 2 Day 3 Day 4 (d~g) 223' 55/40/5 IOAII-EA/PMMAMac 0.45 15.2 PG; 25.4 ML; 20/508 100 85 65

GML

247. 55/40/5 IOA/HEA/PMMAMac 0.45 15.2 PG; 25.4 ML; 20/508 100 95 85

GML

22' 55/40/5 IOA/HECA/PMMAMac 0.45 10. 1 PG; 30.5 ML; 20/508 100 90 75

GML

T2-T 55/40/5 IOA/HEAIPMMAMac 0.45 10. 1 PG, 30.5 ML; 20/508 100 95 85

GML

227' 55/40/5 IOAIHEAIPMMAMac 0.45 5.1 PG; 35.5 ML; 20/508 100 90 85 415

GML

0 0

S

.0@ 649@ 0 S. 0 0g

S

SS S 04 *0 .05 see 060 00 0 @00 *o so 00 0 0 Table 8 Example Copolymer Softener Wet Coating Adhesion Number Thickness (miV/1M) Type iv DayO0 DaylI Day 2 Day 3 Day 4 (dl/g) 22" 55/40/5 [OAIHEA/PMM4AMac 0.45 5.1 PG; 35.5 NIL; 20/508 100 90 75

GML

22' 60/35/S IOA/HEAIPMM4AMac 0.75 15.2 PG; 25.4 ML; 20/508 100 95 65 OFF

GML

230'.2 60/35/5 IOAIHEAIPMMAAMac 0.75 15.2 PG; 25.4 ML; 20/508 100 100 98 60 R

GML

231 60/35/5 IOAII-EAIPMMAtac 0.75 10. 1 PG; 30.5 ME; 20/508 100 95 85 10 It

GML

232'-' 60/35/5 IOAIHEAIPMMAVL ac 0.75 10. 1 PG, 3 0.5 ML; 20/508 100 100 100 -98 It

GML

0 00@ 0 S

S

0@S gee O oe @0 0 S. e g *0 5 0 e S S C e** 0 0 000 0 0e 0000 ego 0 gO 0 S go Gee 0 0g@ 0 S @0 Ce Table 8 Example Copolymer Softener Wet Coating Adhesion Number Thickness (mil/VM) Type iv Day0 Dayl Day2 Day3 Day4 (dVg) 233 60/35/5 IOA/HEA/PMMAMac 0.75 5.1 PG; 35.5 ML; 20/508 100 95 10 R

GML

234' 2 60/35/5 IOA/HEA/PMMAMac 0.75 5.1 PG; 35.5 ML; 20/508 100 100 100 -95 R

GML

235 55/40/5 IOA/HEA/PMMAMac 0.45 30 OA 15/381 100 95 80 60 236 55/40/5 IOA/HEA/PMMAMac 0.45 44 OA 15/381 100 85 70 65 OFF 237 55/40/5 IOA/HEA/PMMAMac 0.45 30 ML 15/381 100 50 OFF 238 55/40/5 IOA/HEA/PMMAMac 0.45 44 ML 15/381 100 90 65 OFF 239' 59/40/1 IOA/HEA/PMMAMac* 0.68 10.2 PG; 30.5 ML; 15/381 100 80 80 78

GML

Table 8 Example Copolymer Softener Wet Coating Adhesion Number Thickness (mul/pM) -Type iv DayO0 DaylI Day 2 Day 3 Day 4 (dL/g) 240' 59/39/2 IOA/HEA/PMMAMac* 0.63 10.2 PG; 30.5 ML; 15/38 1 100 95 -93 90

GML

241P 58/39/3 IOA/HEA/PMMAMac* 0.62 10.2 PG; 30.5 ML; 15/381 100 -92 -88 40 R

GML

242' 58/38/4 IOA/HEA/PMMA~ac* 0.69 10.2 PG; 30.5 ML; 15/381 100 85 75 40 R

GML

24' 59/40/1 IOAIHEAIPMMAMac* 0.68 10.2 PG; 30.5 ML; 25/635 100 90 80 75

GML

244' 59/39/2 IOA/HEAIPMM4AMac* 0.63 10.2 PG; 30.5 ML; 25/635 100 100 100 100

GML

Table 8 Example Copolymer Softener Wet Coating Adhesion(% Number Thickness (milj.AM) Type iv DayO0 Day!I Day 2 Day 3 Day 4 (d~g) 245' 58/39/3 IOA.IHEAIPMIvfAMac* 0.62 10.2 PG; 30.5 NIL; 25/635 100 100 90 -88 s0

GML

246' 58/38/4 IOAIHEA/PMMAMac* 0.69 10.2 PG; 30.5 ML; 25/63 5 100 -98 -96 95 610

GML

24' 57/38/5 IOA/I-EAIPSMac 0.55 10.2 PG; 30.5 MS; 15/38 1 80 65 65 OFF

GML

248' 57/38/5 IOAIHEAIPSMac 0.32 10.2 PG; 30.5 ML; 15/38 1 95 85 80 75 R GM1L 249 57/38/5 IOAJHEAIPSMac 0.55 44 EQ 15/38 1 100 85 70 60 R 250 57/38/5 IOA/H-EAJPSMac 0.55 44 OA 15/38 1 95 70 20 OFF 251 57/39/5 I0A1-EAIPSMac 0.55 44 ML 15/381 95 75 55 50 R Table 8 Example Copolymer Softener Wet Coating Adhesion Number Thickness (ndV/1iM) Type iv DayO0 DaylI Day 2 Day 3 Day 4 (d~g) 252 57/38/5 IOA.JHIEAIPSMac 0.55 30 EO 20/508 100 95 80 75 R 253 57/38/5 IOAIHEAIPSMac 0.55 30 OA 20/508 100 OFF 254 57/38/S IOAIHEA/PSMac 0.55 30 ML 20/508 100 30 R 255 57/38/5 IOAJI-EA/PSMac 0.55 30 1PM 20/508 100 -98 -95 -93 OFF 256 57/38/5 IOAII-EAIPSMac 0.55 44 EQ 20/508 100 OFF 257 57/38/5 IOAIEA/PSMac 0.55 44 OA 20/508 100 OFF 258 57/38/5 IOAJI-EAIPSMac 0.55 44 ML 20/508 100 '50 35 35 OFF 259 57/38/5 IOAIHLEA/PSMac 0.55 44 1PM 20/508 100 80 70 50 OFF 260' 57/38/5 IOA!HEAIPSMac 0.32 10.2 PG; 30.5 NIL; 20/508 100 70 45 45 OFF

OML

Table 8 Example Copolymer Softener Wet Coating Adhesion Number Thickness Type iv DayO0 Day!I Day 2 Day 3 Day 4 (d~g) -T1 57/3815 IOA/HEA/PSMac: 0.55 10.2 PG; 30.5 ML; 20/508 100 80 80 OFF OFF

GML

*PN~

4 tA4ac is ELVACITE 1020 'Formulation also contained 1.5% DDAO 'Adhesion test conducted on subject's right arm