AU7688298A - Spirocyclopropyl fluorenes as melatonergic agents - Google Patents

Spirocyclopropyl fluorenes as melatonergic agents

Info

Publication number
AU7688298A
AU7688298A AU76882/98A AU7688298A AU7688298A AU 7688298 A AU7688298 A AU 7688298A AU 76882/98 A AU76882/98 A AU 76882/98A AU 7688298 A AU7688298 A AU 7688298A AU 7688298 A AU7688298 A AU 7688298A
Authority
AU
Australia
Prior art keywords
spirocyclopropyl
fluorenes
melatonergic agents
melatonergic
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU76882/98A
Inventor
Karen L. Leboulluec
Katherine S. Takaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AU7688298A publication Critical patent/AU7688298A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/94—Spiro compounds containing "free" spiro atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU76882/98A 1997-05-23 1998-05-19 Spirocyclopropyl fluorenes as melatonergic agents Abandoned AU7688298A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4748597P 1997-05-23 1997-05-23
US60047485 1997-05-23
PCT/US1998/010206 WO1998052554A1 (en) 1997-05-23 1998-05-19 Spirocyclopropyl fluorenes as melatonergic agents

Publications (1)

Publication Number Publication Date
AU7688298A true AU7688298A (en) 1998-12-11

Family

ID=21949252

Family Applications (1)

Application Number Title Priority Date Filing Date
AU76882/98A Abandoned AU7688298A (en) 1997-05-23 1998-05-19 Spirocyclopropyl fluorenes as melatonergic agents

Country Status (2)

Country Link
AU (1) AU7688298A (en)
WO (1) WO1998052554A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE354098T1 (en) * 1998-12-28 2007-03-15 Takeda Pharmaceutical SCREENING PROCEDURE
CN106565503B (en) * 2016-10-19 2018-04-24 华北理工大学 The method for synthesizing (1R, 2S) -1- amino-(3,4- difluorophenyls)-cyclopropane
CN106631887B (en) * 2016-10-19 2018-03-20 杨绮红 A kind of preparation technology of (1R, 2S) 1 cyano group 2 (3,4 difluorophenyl) cyclopropane

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3423461A (en) * 1965-10-19 1969-01-21 Smithkline Corp 2-amino- or aminoalkylene-10',11'-dihydrospiro(cyclopropane - 1,5' - 5h-dibenzo-(a,d)cycloheptenes) and the salts thereof
SE361306B (en) * 1971-06-11 1973-10-29 Astra Laekemedel Ab
US3855295A (en) * 1973-06-15 1974-12-17 Searle & Co 6-{8 SPIRO-4{40 -(OPTIONALLY SUBSTITUED AMINO) CYCLOHEXYL{9 -1,1a,6,10b-TETRAHYDRODIBENZO {8 a,e{9 CYCLOPROPA{8 c{9 CYCLOHEPTENES

Also Published As

Publication number Publication date
WO1998052554A1 (en) 1998-11-26

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase