AU767582B2 - The use of a botanical substance given in high dilution to treat or prevent pathologic infiltration of the phospholipid cytoplasmic outer membrane of the human cell - Google Patents

Description

ANDREW J. POLLITT SND. Dirr. D.Ac. D.Hom.

S* NATUROPATH HOMOEOPATH *ACUPUNCTURIST IRIDOLOGIST 4C b D"e, ran u en 1 V (0359958 INVENTION TITLE THE USE OF A BOTANICAL SUBSTANCE GIVEN IN HIGH DILUTION TO TREAT OR PREVENT PATHOLOGIC INFILTRATION OF THE PHOSPHOLIPID CYTOPLASMIC OUTER MEMBRANE OF THE HUMAN CELL 1 The following statement is a full description of this invention including the best method of performing it known to me The protective membrane of the Human Cell is composed of three major types of Phospholipids These are Lecithins Cephalins ,and Sphingomyelins Phospholipids are the major lipids in cell membranes Penetration and pathologic damage to the human cell wall can occur from many types of noxious stimuli These can be bacterial or viral in origen Damage and penetration to the cell phospholipid membrane can also occur when the bodies own antibodies attack healthy cells as if the normal tissue antigenic proteins have not been seen or recognized by the bodies own antibodies. Thus they are attacked as if they are foreign or pathogenic cells. A failure of the body to recognize self. This is the area of Auto Immune Disease.

Bacterial examples of cell wall phospholipid damage can be seen when the Alpha Toxin produced by Clostridia 20 Perfringens and other Clostridia Bacteria acts as a powerful Lecithinase causing massive hemolysis as it penetrates and destroys normal cell walls Staphylococcus Aureus produces a powerful coagulase which breaks down the normal phospholipid cell wall causing massive cell destruction.

The Hemolytic Streptococcus also causes hemolysis of normal human cells causing destruction of normal protective phospholipid cell wall membranes SA method of treatment that could cause inhibition of the 30 pathologic phospholipid damage caused by the above described Bacteria would be of use to those people in need of such treatment Currently many therapies attempt to destroy these pathogenic Bacteria; however very few if any attempt as 35 does this treatment to instead strengthen the cell to prevent or reduce bacterial penetration of the cell wall, GRAYS ANATOMY: CELL STRUCTURE "Both external and internal membranes (cytomembranes) have many features in common. They are all composed chemically of phospholipids, and proteins, usually in an approximately 3:2 ratio with a small amount of carbohydrate." Question How important would it be if you could reduce reverse or inhibit Phospholipid damage in Multiple Sclerosis MULTIPLE SCLEROSIS (MS) The Demyelination of central and peripheral nerves is the the principal cause which then manifests the symptom picture in Multiple Sclerosis.

Lipids constitute about 75% of the dry weight of Myelin and these include cerebroside, phospholipids ,and cholesterol The lesions of MS consist of scattered areas of dissolution of CNS myelin within which the axons remain intact A method of treatment that could protect the Lipid- Phospholipid Myelin Sheath from Auto antibody, viral, or currently unknown causes would be of use to people in need of such treatment.

This method of protecting the phospholipid membrane would be of use even if the cause remains un known 60 SYSTEMIC LUPUS ERYTHEMATOSIS (SLE) Question How important would it be if you could reduce, reverse, or inhibit Phospholipid damage in SLE In the Auto Immune Disease SLE Phospholipid damage is Known to occur when phospholipid cell membranes on normal platelets are destroyed probhably by the bodies own antibodies Although there may be viral or as yet unknown causes This results in a decrease in the total number of platelets Thrombocytopenia) A method of treatment that could inhibit phospholipid damage to these platelets would be of use to those in need of such treatment This treatment could be applied to other types of cell destruction in SLE Any Cell that has been destroyed has had its protective phospholipid cell wall penetrated and damaged Question How important would it be if you could reduce reverse or inhibit the powerful Lecithinase Phospholipase effect of the Alpha Toxin produced by Clostridia Perfringens,and other Clostridia Bacteria that causes massive hemolysis to tissue as it destroys Human cell phospholipid protective cell membranes? CLOSTRIDIA PERFRINGENS (ALPHA TOXIN) Intravenous administration of Alpha Toxin in experimental animals causes massive hemolysis ,platelet destruction, and wide spread capillary damage.

A method of treatment that could cause inhibition of the effects of the Alpha Toxin produced by Clostridia Perfringens would be of use to those people in need of such treatment Question How important would it be if you could reduce, reverse, or inhibit the powerful coagulase with anti phospholipid properties produced by the Bacteria Staphylococcus Aureus STAPHYLOCOCCUS AUREUS A variety of studies in experimental models has shown a high correlation between coagulase production and organism virulence In the community Staphylococcus, particularly Staph Aureus are the leading cause of acute, serious, and progressive skin, soft tissue, and post traumat.ic infections 105 For the first time in our history there are now strains of Staph-Aureus that are resistant to all known AntiBiotic therapy, including Vancomycin A method of treatment that could cause inhibition of the coagulase that dammages the Phospholipid membrane of the 110 human cell would be of use to those people in need of such a treatment *o o Question How important would it be if you could reduce, reverse, or inhibit the anti phospholipid hemolysis caused by the 115 Hemolytic Streptococcal group of Bacteria? HEMOLYTIC STREPTOCOCCAL BACTERIA The hemolysis of normal cell walls and subsequent destruction of normal human phospholipid cell wall membranes caused by the Hemolytic group of Bacteria 120 Streptococci is the cause of many common infections in the community and can cause sepsis and systemic illness.

Common diseases caused by Streptococci include sore throat skin infections, pneumonia, food poisoning, septicemia, urinary tract infections.

125 A method of treatment that could cause inhibition of the hemolytic effect of the Hemolytic group of Streptococci Bacteria would be of use to those people in need of such a treatment THE THERAPEUTIC PROPERTIES OF THE BOTANICAL SUBSTANCE 130 AESCULUS HIPPOCASTANUM( HORSE CHESTNUT WHEN GIVEN IN HIGH DILUTION A PLANT CONTAINING SAPONOSIDES So far in this specification there have been described two types of Pathology; Auto immune, and Bacterial.

135 Plants containing saponosides have the property of reducing the surface tension of water as a result of this they also have the property of increasing 'the permiability of membranes As a result of this, plants in this group have hemolytic 140 properties which varies considerably 145 *eeo 145 o* o* *o Saponosides also have the effect of inhibiting the vital activities of the protoplast of the cell

SUMMARY

Saponosides :*Have Hemolytic properties *Cause inhibition of the vital activities of the cell Protoplast.

THE THERAPEUTIC PROPERTIES OF THE BOTANICAL SUBSTANCE AESCULUS HIPPOCASTANUM HORSE CHESTNUT) WHEN GIVEN IN HIGH DILUTION, contd 150 History tells us that Dr Samual Hahnemann born in Miessen Germany in 1775, and died in Paris in 1843 carried out study using medicines in high dilutions culminating in the publication of his major work The Organon This work is based on the "The Law of Similars".

155 THE LAW OF SIMILARS can be understood by the following Definition.

1 Any pharmacologically active substance will bring about a group of symptoms which are characteristic of that particular substance if it is administered to a 160 healthy sensitive person.

2 All ill people display a group of symptoms which are characteristic of their disease.

3 A successful treatment which may be said to be complete when the morbid symptoms have ceased may be 165 brought about by prescribing weak or infinitesimal doses of the substance whose experimental symptoms see first premise are similar to those displayed by the patient AESCULUS HIPPOCASTANUM contains a glycoside, esculoside, whose aglycone is esculetol a coumarin in weak amounts.

170 Coumarin if we consider premise 1 above) of the Law Of Similars reduces normal coagulation by causing inhibition of hepatic synthesis of vitamin K dependent coagulation factors SUMMARY REVIEW 175 Saponosides: Have haemolytic properties Cause inhibition of the vital activities of the cell protoplast Coumarin Has haemolytic properties (inhibits coagulation) 180 PHARMACOLOGICAL PROPERTIES: Given in high dilutions) Anti haemolytic properties.

Reduced inhibition of the vital.

metabolic activities of the Phospholipid outer membrane of the human cell.

185 Anti, Anti Phospholipid properties.

SUMMARY REVIEW (Bacteria) Clostridia Perfringens: produces Alpha Toxin, a powerful Lecithinase phospholipase that causes massive hemolysis in cell tissue 190 Staphylococcus Aureus produces a powerful coagulase that causes massive hemolysis in cell tissue.

Hemolytic Streptococcus: causes massive hemolysis in cell tissue All 3 Bacteria can cause moderate to massive hemolysis 195 dependent on such factors as organism virulence and the state of resistance of the host As these Bacteria cause injury to the cell.They cause inhibition to the cells primary defence to commence the formation of a clot A poor response from the 200 host can result in the Bacteria advancing further destroying more cell tissue as it advances..

Hemolysis causes injury to the phospholipid outer layer of the cell wall. However phospholipid injury is one of the primary initiators of the intrinsic and extrinsic .205 clotting pathway Therefore Bacterial Hemolysis attempts to extinguish or S inhibit one of the bodies primary mechanisms for initiating clot formation, and collagen repair This hemolysis has very strong anti phospholipid properties Therefore a treatment that could reduce Bacterial hemolysis of the primary outer phospholipid membrane of the cell could help reduce the destructive pathology initiated by the Bacterial hemolysis 215 This would be a treatment that focuses on increasing the resistant strength of the cell rather than being toxic 00. to the Bacteria, as is the case with Antibiotic Therapy.

Such a treatment of protecting the phospholipid outer membrane of the cell from Bacterial Hemolysis would be 220 of use to those people in need of such treatment Such a treatment could significantly reduce the advance of the pathology initiated by these Bacteria AUTO IMMUNE DISEASE MULTIPLE SCLEROSIS 225 Demyelination of the nerves Myelin sheath is the principal pathology in MS If we consider that Lipids constitute 75% of the dry weight of Myelin, then a treatment that had protective properties specific to the phospholipids of the Myelin 230 sheath could greatly reduce the advance or anti phospholipid effect on normal phospholipid tissue.

SYSTEMIC LUPUS ERYTHEMATOSIS (SLE) Destruction of normal cells by the bodies own antibodies is the principal pathology in SLE 235 The primary physiological protection of every cell in the body is the Phospholipid Cytoplasmic outer membrane of the cell Phospholipids fulfill a variety of body functions, including cellular membrane composition and permiability, and some control of enzyme activity within 240 the the membrane In SLE cell destruction can be organ specific ie when an organ specific antigen- antibody complex causes destruction of a specific organ or tissue type Destruction can also be non specific where seemingly any S 245 cell may become the focus of antigen antibody pathology Destruction of any cell implies that the protective phospholipid outer membrane of the cell has been damaged and penetrated 250 A treatment that had protective properties specific to the outer phospholipid membrane of the cell that caused inhibition to the cell destruction due to the effect of antigen antibody destruction of the cells phospholipid cytoplasmic outer membrane would be of use 255 to those in need of such treatment *e* PREPERATION OF THE ACTIVE SUBSTANCE MOTHER TINCTURE of Aesculus Hippocastanum is produced from fresh ripe Horse Chestnuts of which the outer case is removed and discarded, and (only the seed is used). The seeds are spread to dry for 3 days at room temperature 15-30 degrees 260 centigrade. The seeds can then be sliced into 3 to 4 sections to increase surface area for maceration. One part (by volume) of the seed is then added to five parts (by volume) of 70% ethyl alcohol, 30% distilled water in a clean sterile glass container.

This mixture is then stored at room temperature 15 30 degrees centigrade for 7 days to allow maceration to occur. Following this the seeds can be lightly pressed, or 265 squeezed, and then all of the contents are strained and filtered through a single use cloth or paper filter to eliminate particulate material. The remaining fluid is the mother tincture, and is stored in a dark glass jar below 30 degrees centigrade out of direct sunlight.

Confirmation testing for this traditional method of mother tincture preparation can be 270 done by thin layer chromatography TLC. This is an accepted method in the herbal industry to confirm the specific individual herbal plant is genuine and valid. Also observation of characteristic darkened coloration indicating maceration has occurred.

HOMOEOPATHIC SERIAL DILUTION OF THE MOTHER TINCTURE Homoeopathic serial dilution using the Centesimal scale is used. The centesimal S 2 7 5 scale of dilution refers to a dilution ratio of one part mother tincture to 99 parts of S* 70% ethyl alcohol and 30% distilled water. Various manufacturers may use different ratios of ethyl alcohol and distilled water.

A dilution of one part mother tincture added to 99 parts ethyl alcohol and distilled S" water is named as lc dilution.

2 80 One part of the Ic dilution added to 99 parts ethyl alcohol and distilled water is named as 2c dilution.

One part of the 2c dilution added to 99 parts ethyl alcohol and distilled water is named as 3c dilution, and so forth.

Succussion or shaking the mixture strongly is vital following each combining of the 285 one part of the previous dilution to 99 parts ethyl alcohol and distilled water. This is said to potentize the medicine and failure to do this may produce an ineffective homoeopathic medicine.

SCOMMERCIAL SUPPLY Homoeopathic dilutions ofAesculus Hippocastanum (Horse Chestnut have been 290 Obtained from commercial manufacturers.

Brauer Biotherapies: 1 Para Rd, Tanunda, South Australia The Pharmaceutical Plant Company, 24 London Drive, Bayswater, Victoria 8 (A) AESCULUS HIPPOCASTANUM (HORSE CHESTNUT) PHARMACOLOGICAL PROPERTIES WHEN GIVEN IN HIGH DILUTION 295 Anti haemolytic properties.

Reversal of inhibition of the vital metabolic activities of the cytoplasmic phospholipid outer membrane of the human cell caused by the pathological effect of destructive cell tissue haemolysis.

Anti, Anti phospholipid properties.

300 KEY STATEMENT Pathological haemolysis whether caused by the destructive effects of the 3 named bacteria; or whether caused by Autolysis; haemolysis caused by the effect of an active antigen antibody complex can cause great pain and suffering, an at times death.

305 The best method known to me of performing the invention that can cause inhibition of the destructive pathology described in this specification caused by the bacteria Clostridia Perfringens Alpha Toxin) Staphylococcus aureus 310 Type A beta haemolytic Streptococcus, And the diseases known as Multiple Sclerosis Systemic Lupus Erythematosis 3 can be carried out by giving to a person in need of such treatment, a mother tincture of 315 the seed of the fruit of the botanical plant Aesculus Hippocastanum diluted by homoeopathic serial dilution using the centesimal scale of dilution, the lower range being 3c, the higher dose rang being 15c, with dosages of 6c and 9c being used to provide effective treatment for most individuals in need of such treatment, administered orally as 1.18 ml 20 drops one time daily or one time every second 320 day given between meals not with food, these serial dilutions being in compliance with British and European homoeopathic pharmacopoeia standards.

EDITORIAL NOTE APPLICATION NUMBER 199959432 The following claim page has not been numbered by the applicant.