AU7651681A - Penicillins - Google Patents

Penicillins

Info

Publication number
AU7651681A
AU7651681A AU76516/81A AU7651681A AU7651681A AU 7651681 A AU7651681 A AU 7651681A AU 76516/81 A AU76516/81 A AU 76516/81A AU 7651681 A AU7651681 A AU 7651681A AU 7651681 A AU7651681 A AU 7651681A
Authority
AU
Australia
Prior art keywords
formula
hydrogen
group
lower alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU76516/81A
Other versions
AU547251B2 (en
Inventor
Solange Adam-Molina
Werner Hofheinz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU7651681A publication Critical patent/AU7651681A/en
Application granted granted Critical
Publication of AU547251B2 publication Critical patent/AU547251B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)

Abstract

There are presented beta -lactams of the formula <IMAGE> I wherein R1 is cyano or a group of the formula R4-CO- or R5-A-CO-, R2 is hydrogen, lower alkyl or halogen, R3 is hydrogen or a group readily cleavable by hydrolysis, n is the number 0, 1 or 2, R4 is hydrogen, hydroxy, lower alkoxy, lower alkyl, aryl or a group of the formula <IMAGE> R5 is halogen, lower alkoxy, lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, aryl, aryloxy, arylthio, arylsulphinyl, arylsulphonyl or di-(loweralkoxy)phoshinyl, R6 and R7 are lower alkyl and A is lower alkylene, and pharmaceutically acceptable salts of carboxylic acids of formula I with bases. The compounds exhibit pronounced beta -lactamase-inhibiting properties.
AU76516/81A 1980-10-24 1981-10-16 Penicillins Ceased AU547251B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH7946/80 1980-10-24
CH794680 1980-10-24

Publications (2)

Publication Number Publication Date
AU7651681A true AU7651681A (en) 1982-04-29
AU547251B2 AU547251B2 (en) 1985-10-10

Family

ID=4332789

Family Applications (1)

Application Number Title Priority Date Filing Date
AU76516/81A Ceased AU547251B2 (en) 1980-10-24 1981-10-16 Penicillins

Country Status (12)

Country Link
US (1) US4512999A (en)
EP (1) EP0050805B1 (en)
JP (1) JPS5799590A (en)
AT (1) ATE14434T1 (en)
AU (1) AU547251B2 (en)
CA (1) CA1180005A (en)
DE (1) DE3171499D1 (en)
DK (1) DK470181A (en)
IL (1) IL64073A (en)
NZ (1) NZ198672A (en)
PH (1) PH17984A (en)
ZA (1) ZA817194B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3265578D1 (en) * 1981-05-14 1985-09-26 Beecham Group Plc Modified beta-lactam compounds
EP0120613A1 (en) * 1983-03-02 1984-10-03 Beecham Group Plc Penem derivatives and precursors
US4647457A (en) * 1983-12-16 1987-03-03 Hoffmann-La Roche Inc. Penicillanic acid derivatives
DE3584015D1 (en) * 1984-01-30 1991-10-17 Pfizer 6- (SUBSTITUTED) METHYLENE PENICILLANIC ACID AND 6- (SUBSTITUTED) HYDROXYMETHYL PENICILLANIC ACID AND THEIR DERIVATIVES.
US5015473A (en) * 1984-01-30 1991-05-14 Pfizer Inc. 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
US4826833A (en) * 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
EP0170192B1 (en) * 1984-07-30 1992-05-13 Merck & Co. Inc. Penicillin derivatives as anti-inflammatory and antidegenerative agents
US5464616A (en) * 1994-08-04 1995-11-07 Synphar Laboratories, Ind. 6β-substituted penicillanic acids as beta-lactamase inhibitors
DE69815395T2 (en) 1997-12-29 2004-05-13 Research Corp. Technologies, Inc., Tucson METHOD FOR PRODUCING ALPHA OXOLACTAMS
ES2178301T3 (en) * 1997-12-29 2002-12-16 Res Corp Technologies Inc DERIVATIVES OF PENICILANIC ACID 2-BETA-SUBSTITUTED-6-RENTED AS INHIBITORS OF BETA-LACTAMA.
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
CA2454413A1 (en) 2001-07-24 2003-03-13 Alamx, L.L.C. 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors
JP2005525399A (en) 2002-04-04 2005-08-25 アラムクス エルエルシー Inhibitors of serine and metallo-β-lactamases
US8299051B2 (en) * 2008-05-13 2012-10-30 Southern Methodist University Beta-lactamase inhibitory compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714156A (en) * 1970-06-22 1973-01-30 Univ California Lactam process
US4020077A (en) * 1972-07-21 1977-04-26 Glaxo Laboratories Limited Antibiotics
JPS5749555B2 (en) * 1973-04-04 1982-10-22
US4207323A (en) * 1975-11-21 1980-06-10 Merck & Co., Inc. 6-Substituted methyl penicillins, derivatives and analogues thereof
US4053468A (en) * 1976-02-25 1977-10-11 Smithkline Corporation Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
US4236001A (en) * 1976-12-01 1980-11-25 Smithkline Corporation 7β-Acyloxy-3-heterocyclicthiomethyl cephalosporins
US4282149A (en) * 1977-03-21 1981-08-04 Massachusetts Institute Of Technology Carbon and oxygen analogs of penicillin
US4123539A (en) * 1977-12-29 1978-10-31 Merck & Co., Inc. 6-Ethylpenicillanic acid

Also Published As

Publication number Publication date
ZA817194B (en) 1982-09-29
JPS5799590A (en) 1982-06-21
EP0050805B1 (en) 1985-07-24
PH17984A (en) 1985-02-26
IL64073A0 (en) 1982-01-31
EP0050805A1 (en) 1982-05-05
ATE14434T1 (en) 1985-08-15
CA1180005A (en) 1984-12-27
IL64073A (en) 1984-09-30
DK470181A (en) 1982-04-25
AU547251B2 (en) 1985-10-10
NZ198672A (en) 1985-05-31
DE3171499D1 (en) 1985-08-29
US4512999A (en) 1985-04-23

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