AU758983B2 - Use of a COX-2 inhibitor and a NK-1 receptor antagonist for treating inflammation - Google Patents

Use of a COX-2 inhibitor and a NK-1 receptor antagonist for treating inflammation Download PDF

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AU758983B2
AU758983B2 AU39486/99A AU3948699A AU758983B2 AU 758983 B2 AU758983 B2 AU 758983B2 AU 39486/99 A AU39486/99 A AU 39486/99A AU 3948699 A AU3948699 A AU 3948699A AU 758983 B2 AU758983 B2 AU 758983B2
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Prior art keywords
phenyl
methylsulfonyl
fluorophenyl
benzenesulfonamide
trifluoromethyl
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AU3948699A (en
Inventor
Susan Boyce
Raymond George Hill
Nadia Melanie Rupniak
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Organon Pharma UK Ltd
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Merck Sharp and Dohme Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Description

WO 99/59635 PCT/GB99/01632 USE OF A COX-2 INHIBITOR AND A NK-1 RECEPTOR ANTAGONIST FOR TREATING INFLAMMATION The present invention involves a drug combination comprising an inhibitor of cyclooxygenase-2 in combination with a neurokinin-1 (NK-1) receptor antagonist.
Inhibitors of cyclooxygenase-2 are a sub-class of the class of drugs known as non-steroidal antiinflammatory drugs (NSAIDs). The NSAIDs are active in reducing the prostaglandin-induced pain and swelling associated with the inflammation process but are also active in affecting other prostaglandin-regulated processes such as maintenance of the gastric lining. Thus, use of high doses of most common NSAIDs can produce severe side effects, including life threatenting ulcers, that limit their therapeutic potential. An alternative to NSAIDs is the use of corticosteroids, which have even more serious side effects, especially when long term therapy is involved.
Previous NSAIDs have been found to prevent the production of prostaglandin by inhibiting enzymes in the human arachidonic acid/prostaglandin pathway including the enzyme cyclooxygenase (COX).
There are two isoforms of the COX enzyme, the first, COX-1, is constitutively expressed and is involved with physiological functions and the second, COX-2, is induced locally in inflamed tissue. While conventional NSAIDs block both forms of the enzyme, the inducible COX-2 enzyme associated inflammation has provided a more focussed drug target which should enable effective antiinflammatory analgesia with reduced gastrointestinal side effects. Many compounds which have activity as COX-2 inhibitors have been identified, and clinical trials are reported to be in progress.
Neurokinin 1 (NK-1; substance P) receptor antagonists are being developed for the treatment of a number of physiological disorders associated with an excess or imbalance of tachykinins, and in particular substance P. Substance has been implicated in the pathology of a number of inflammatory conditions (see, for instance, International (PCT) patent specification Nos.
WO 95/16679, WO 95/18124 and WO 95/23798).
Improved therapies for treating and preventing inflammatory disorders are currently being sought for the large number of individuals who are at risk from these disorders.
The present invention addresses this problem by providing a combination therapy comprised of a COX-2 inhibitor with a NK- 1 receptor antagonist. When administered as part of a combination therapy, the COX-2 inhibitor together with the NK-1 receptor antagonist provide enhanced treatment options as compared with administration of either to the COX-2 inhibitor or the NK- 1 receptor antagonist alone.
According to a first embodiment, the present invention provides use of a selective COX-2 inhibitor and a NK- 1 receptor antagonist for the manufacture of a medicament for the treatment or prevention of an inflammatory disorder, wherein said selective COX-2 inhibitor is selected from the group consisting of: 3 -phenyl- 4 -(4-(methylsulfonyl)phenyl)-2-(5H)- uranone; 3 3 4 -difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-fjranone; 5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3 -(3-fluorophenyl)-5H-furan-2-one; 5,5-dimethyl-4-(4-methylsulfonyl)phenyl)3-2poxy5Hfrn-ne 3 4 -(methysu lfonyl)pheny1)-2-(2methyl..-pyridinyl)pyridine; 2-(3,5-difluorophenyl)-3 4 -(methylsulfonyl)phenyl)-2-cyclopenten- 1 -one; i 5(S)-5-ethyl-5 -methyl-4 -(4-(methyl sulfonyl)phenyl)-3 -propoxy)-5H-furan-2-one -ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3.(3 ,4-dufluorophenyl)-5H-flran-2-one; 2 -thiazolyl)methoxy)-4-(4(methylsulfonyl)phenyly5,5dimethyl5Hfuran2.one; 3-propyloxy-4-(4-methylsulfonyl)phenyly5,5-dimethyl-5H-furan-2-one; 3-(1 -cyclppylethoxy)-5,5-dimethyl-4-(4-(m sodium 2-(4-chlorophenyl)-3 4 -(methylsulfonyl)phenyl)-4-oxo-2-pentenoate; ,5-dimethyl-4-(4-(methylsulfony)phenylysH-fran-2-one; ,-dimethyl-4-(4-(methylsulfonyl)phenyl>2,sdihydrofran2ol; 3-isopropoxy-5 ,-dimethy-4-(4-(methylsulfony)phenyl)-2,5-dihydrofuran2-ol; [R:\LIBH]03976.doc:aak 5,5-dimethyl-3.(3-fluoropheny)2.hydroxy-4.(4..(methylsulfonyl)phenyl)- 5-hoo3(-mtysloy~hey)2(-yiiy~yiie 4 -(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; 5-(4-fluorophenyl)-1- [4-(methylsulfonyl)phenylJ -3- (trifluoromethyl)pyrazole; 4-(4-fluorophenyl)-5- [4-(methylsulfonyl)phenylJ -1-phenyl-3- (trifluoromethyl)pyrazole; 4 4 -chlorophenyl)-3-(4-methoxyphenyl)1Hpyrazol-1.
yl)benzenesulfonamnide; 4 3 ,5-bis(4-methylpheny)-lHpyrazo1...y1)benzenesufonanide; 4 4 -chlorophenyl)-3-(4-methylphenyl).lHpyrazol1..
yl)benzenesulfonamide; 4 4 -chlorophenyl)-3-(4nitrophenyl).lHpyrazol.1.
yl)benzenesulfonamide; 4 4 -chlorophenyl)-3-(5-choro2thienyl)1lH..pyazol-lyl)benzenesulfonamide;* 4 4 -chloro-3,5-dipheny11H-pyazol.1-y1)benzenesulfonamide; 4 4 -chlorophenyl)-3-(trifluoromethyl)lH-pyrazol-lyl)benzenesulfonamide; 4 4 -fluoropheny)-3-(trifluoromethyly..1Hpyraz11...
yl)benzenesulfonamide; 4 4 -methoxyphenyl)-3-(trifluoromethyl)>1H..pyazol-l-.
yl)benzenesulfonamide; 4 4 -chlorophenyl)-3-(difluoromethyl)1Hpyrazol-lyl)benzenesulfonamide; 4 4 -methylphenyl)-3-trifluoromethyl)y1H-pyaz1.. x Yl)benzenesulfonamide; yl)benzenesulfonamide; 4 3 -(difluoromethyl)-5-(4-methylphenyl)-1H-pyrazol1..
yl)benzenesulfonamide; 4-3(ilooehl--hnll-przl1y~eznsloaie 4 3 -(difluoromethyl)-5-(4-methoxyphenyl).lH-pyrazol-l-.
yl)benzenesulfonamide; 4 3 -cyano-5-(4-fluoropheny)-Hpyrazo11y)benzenesufonamide; 4 3 -(difluoromethy1)-5-(3-fluoro-4-methoxyphenyl)1lHjpyrazol-lyl)benzenesulfonamide; 4 3 -fluoro-4methoxypheny)3-(trfuoromethyl)1lH..pyazol-lyl)benzenesulfonamide; 4-4cloo5phnllHprzo-: ~ezneufnaie 4 4 -chlorophenyl)-3-(hydroxyphenyl)1Hpyrazol.1.
yl)benzenesulfonamide; 4 4 -(N,N-dimethylamino)phenyl)-3-(trifluoromethyl)-1Hpyrazol.. 1 yl)benzenesulfonamide; 5-V14-Iuoropfeny)-t-(4-(methylsulfonyl)pheny1)spiro [2.4lhept-5-ene; 4 6 4 -fluoropheny)spiro[2.4]hept-5.en.5y1)benzenesulfonamide; 6 4 -fluorophenyl)-7-(4-(methylsulfonyl)phenyl)spiro [3 .4loct-6-ene; 3 -chloro-4-methoxyphenyl)-6-(4(methylsulfonyl)phenyl)spiro 12.41 hept- 4 6 3 -chloro-4-methoxyphenyl)spiro [2.4lhept-5-en-5yl)benzenesulfonamide; 5-( 3 ,5-dichloro-4-methoxyphenyl)-6(4.(methylsulfony1)phenyl)- Spiro [2.4]hept-5-ene; 3 -chloro-4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.41 ene; 4 -(6-(3,4-dichlorophenyl)spiro [2.41 2 3 -chloro-4-fluoropheny)-4-(4-fluoropheny)5.(4.
methylsulfonylphenyl)thiazole; 2 2 -chlorophenyl)-4-(4-fluorophenyly..s.(4-.methylsulfonylphenyl)thiazole; 4 -fluorophenyl)-4-(4-methylsulfonylphenyl).2-methylthiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl).2trifluoromethylthiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)2(2-thienyl)thiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl).2-benzylamsnothiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)2(l-propylamhio)thiazole; 2 3 ,5-dichlorophenoxy)methy).4-(4-fluoropheny)-5-(4- (methylsulfonyl)phenyl)thiazole; 5-4furpey)4(-ehlufnypey)2tilooehlhaoe 1-methylsulfonyl-4-(1, l-dimethyl-4-(4-fluorophenyl)cyclopenta-2,4Aien-3yl)benzene; 4 -(4-(4-fluorophenyl)-1, l-dimethylcyclopenta-2,4-dien-3yl)benzenesulfonamide; 4 -fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro hepta-4,6-diene; 4-(6-(4-fluorophenyl)spiro 2 4 lhepta-4,6-dien-5-yL)benzenesulfonainide; 6-( 4 -fluorophenyl)-2-methoxy-5(4-(methysufony)phenyl..pyidine-3.
carbonitrile; 2 -bromo-6-(4-fluoropheny)5-4(methysufony)pheny).pyrdine3carbonitrile; 6 4 -fluoropheny)-5-(4-(methylsulfony1)phenyl)-2-.pheny..pyidine.3 **carbonitrile; 4 2 4 -methylpyridin-2-yl)-4-(trifluoromethyl).lHiidazol-1.
yl)benzenesulfonamide; 4 2 -(5-methylpyridin-3-yl)4-(trifluoromethy)lHimjdazol-l yl)benzenesulfonamnide; 4 2 2 -methylpyridin-3-yl)-4-(trifluoromethyl)..lHimidazol-l-.
yl)benzenesulfonamide; 3 4 -(methylsulfonyl)phenyl)-4-(trifluoromethyly..lH-imidazol-2 yl)benzenesulfonamide; 2 4 -(methylsulfony1)pheny1)-4-(trifluoromethyl)-lH-imdazo12.
yl)pyridine; 2d 2-methyl-4-(l 4(ehlufnlpey)4(tilooehl-Hindzl 2-yl)pyridine; 2-ehl6(-4(ehlufnlpeyl--tilooehl-Hiadzl 2 -yl)pyridine; 4 2 6 -methylpyridin-3-y)4-(trifluoromethy)lHjimidazol-lyl)benzenesulfonamide; 2 3 4 -difluoropheny)-1-(4-(methylsulfonyl)phenyl).4.(tlifluoromethyl)lHimidazole; 4 2 4 -methylphenyl)-4-(trifluoromethyl)1IHimdazol.lyl)benzenesulfonamide; 2 4 -chlorophenyl)4(4-fluorophenyly..1.(4-.(methylsulfonyl)phenyl)lHimidazole; 2 3 -fluoro- 4 -methoxypheny)-l-(4.(methysufony)pheny).4- (trifluoromethyl)-lH-imidazole; 2 4 -methylphenyl)-l-(4-(methylsulfony)pheny)4.tifluoromethy11Himidazole; 20 4 2 3 -chloro-4-methylpheny)4(trifluoromethy).1H-imidazol-l yl)benzenesulfonamide; 2 3 -fluoro-5-methypheny)-(4-(methysufony)pheny)4.
(trifluoromethyl)-1H-imidazole; 4 2 3 -fluoro-5-methylpheny)-4-(trifluoromethy)1Himidazo...1.
yl)benzenesulfonamide; 2 3 -methylphenyl)-1-(4-(methylsulfonyl)phenyl)..4(trifluoromethyl)1Himidazole; 4 2 3 -methylphenyl)-4-(trifluoromethyl..lHimidazol.1.
yl)benzenesulfonamide; l-( 4 -(methylsulfonyl)pheny1)2(-choropheny)4(trifluoromethyl)lHimidazole; 4 2 3 -chlorophenyl)-4-(trifluoromethyl)-lH-imidazol-lyl)benzenesulfonaniide; 4 2 -phenyl-4-(trifluoromethyl)-1H-imidazol..1.yl)benzenesulfonamide; 4 2 4 -methoxy-3-chlorophenyl)-4-(trfluoromethyl)1Himidazol-l1.
yl)benzenesulfonamide; l-allyl- 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl).5-(tifluoromethyl).
IH-pyrazole; 4 -(l-ethyl- 4 -(4-fluorophenyl)-5-(trifluoromethyl)1lHpyrazol-3 yl)benzenesulfonamide; N-pheny1-(4-(4-fluoropheny)-3-(4-(methysufony)pheny).5 ethyl 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)5(tifluoromethyl)lH-pyrazol-1-yl)acetate; 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl).1.(2-.phenylethyl)1H.
pyrazole; 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)1..{2phenylethyl)5.
(trifluoromethyl)pyrazole; l-ethyl- 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5(trifluoromethyl).
1H-pyrazole; 20 5-( 4 -fluorophenyl)-4-(4-(methylsulfonyl)phenyl)2(tirifluoromethyl)IH- :*..*imidazole; 4 4 -(methylsulfonyl)phenyl)-5-(2-tiophenyl).2..(trifluoromethyl)1H.
imidazole; 4 -fluorophenyl)-2-methoxy-4-(4-(methylsulfonyl)phenyl)6- (trifluoromethyl)pyridine; 2 -ethoxy-5-(4-fluorophenyl)-4-(4-(methylsufony)phenyl)6.
(trifluoromethyl)pyridine; 4 -fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(2propynyoxy)6- (trifluoromethyl)pyridine; 2 -bromo-5-(4-fluorophenyl)-4-(4..(methylsulfonyl)phenyl).6- (trifluoromethyl)pyridine; l-( 4 -fluorophenyl)-2-(4-(methylsulfonyl)phenyl)benzene; 5-difluoromethyl-4-(4-(methylsulfonyl)phenyl)-3phenylisoxazole; 4 3 -ethyl-5-phenylisoxazol-4-yl)benzenesulfonamide; 4 -(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide; l-( 2 4 -fluorophenyl)cyclopenten-1-yl)-4-(methysulfonyl)benzene; l-( 2 4 -fluoro- 2 -methylpheny)cyclopenten-1-y1)-4-(methylsulfonyl)ibenzene; 1-( 2 2 4 -dichlorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-( 2 4 -trifluoromethylphenyl)cyclopenten-1.y1)-4(methysufonyl)benzene; l-( 2 4 -methylthiophenylcyclopenten-.1y)4(methylsulfonyl)benzene; l-( 2 4 -fluorophenyl)-4,4-dimethylcyclopenten-1yl)4.
(methylsulfonyl)benzene; 4-2(-loohnl-,-iehlycoetn1y~eznsloa-ie l-( 2 4 -chlorophenyl)-4,4-dimethylcyclopenten-1yl).4 (methylsulfonyl)benzene; 4 2 4 -chlorophenyl)-4,4-dimethylcyclopenten-1.yl)benzenesulfonamide; a. 4 2 4 chlorophenyl)cyclopenten-1-yl)benzenesulfonanmjde; l-( 2 4 -methoxphenyl)cyclopenten1y).4(methylsulfony1)benzene; l-( 2 2 3 -difluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 4-2(-loo4mtoyhnlccoetn1y~eznsloaie l-( 2 3 -chloro-4-methoxypheny)cyclopenten-1y1)-4 (methylsulfonyl)benzene; 4 2 3 -chloro-4-fluorophenyl)cyclopenten-1-yl)benzenesulfonamide; 4-2(-ehlyii--lccoetn1y~eznsloaie ethyl 2 4 -(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol2yl)2benzyl-acetate; 2 4 4 -fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol.2-y1)acetic acid; 2g According to a second embodiment the present invention provides a pharmaceutical composition for the treatment or prevention of an inflammatory disorder comprising a selective COX-2 inhibitor and a NK-1 receptor antagonist, together with at least one pharmaceutically acceptable carrier or excipient, wherein said selective COX-2 inhibitor is selected from the compounds of the first embodiment.
According to a third embodiment the present invention provides a product comprising a selective COX-2 inhibitor and a NK-1 receptor antagonist as a combined preparation for simultaneous, separate or sequential use in the treatment or prevention of an inflammatory disorder, wherein said selective COX-2 inhibitor is selected from the compounds of the first embodiment.
According to a fourth embodiment the present invention provides a method for the treatment or prevention of an inflammatory disorder, which method comprises -administration to a patient in need thereof of an amount of a selective COX-2 inhibitor *and an amount of a NK-1 receptor antagonist, such that together they give effective relief 15 wherein said selective COX-2 inhibitor is selected from the compounds of the first embodiment.
According to a fifth embodiment the present invention provides a process for preparing a pharmaceutical composition comprising combining a selective COX-2 .•inhibitor and a NK-1 receptor antagonist with a pharmaceutically acceptable carrier, wherein said selective COX-2 inhibitor is selected from the compounds of the first 0000 embodiment.
O 0 00 According to a sixth embodiment the present invention provides the use of a NK-1 receptor antagonist for the manufacture of a medicament for the combined use with a selective cyclooxygenase-2 inhibitor for preventing or reducing the risk of developing an inflammatory disorder, for halting or slowing the progression of an inflammatory disorder, or for preventing or reducing the risk of occurrence or recurrence of an inflammatory disorder, wherein said selective COX-2 inhibitor is selected from the compounds of the first embodiment.
According to a seventh embodiment the present invention provides the use of a selective cyclooxygenase-2 inhibitor for the preparation of a medicament for the combined use with a NK-1 receptor antagonist for preventing or reducing the risk of developing an inflammatory disorder, for halting or slowing the progression of an inflammatory disorder, or for preventing or reducing the risk of occurrence or recurrence SRA,, of an inflammatory disorder, wherein said selective COX-2 inhibitor is selected from the S 35 ompounds of the first embodiment.
[R:\LIBH]03976.doc:aak 2h According to an eighth embodiment the present invention provides a method of preventing or reducing the risk of developing an inflammatory disorder, for halting or slowing the progression of an inflammatory disorder, or for preventing or reducing the risk of occurrence or recurrence of an inflammatory disorder, said method comprising administration of an NK-1 receptor antagonist combined with administration of a selective cycloxygenase-2 inhibitor, wherein said COX-2 inhibitor is selected from the compounds of the first embodiment.
*S [R:\LIBH]03976.doc:aak WO 99/59635 PCT/G B99/0 632 -3- It will be appreciated that the COX-2 inhibitor and the NK-1 receptor antagonist, may be present as a combined preparation for simultaneous, separate or sequential use for the treatment or prevention of inflammatory disorders. Such combined preparations may be, for example, in the form of a twin pack.
In a further or alternative aspect of the present invention, there is therefore provided a product comprising a COX-2 inhibitor and a NK-1 receptor antagonist as a combined preparation for simultaneous, separate or sequential use in the treatment or prevention of inflammatory disorders.
It will be appreciated that when using a combination of the present invention, both the COX-2 inhibitor and the NK-1 receptor antagonist will be administered to a patient, within a reasonable period of time. The compounds may be in the same pharmaceutically acceptable carrier and therefore administered simultaneously. They may be in separate pharmaceutical carriers such as conventional oral dosage forms which are taken simultaneously. The term "combination" also refers to the case where the compounds are provided in separate dosage forms and are administered sequentially. Therefore, by way of example, the COX-2 inhibitor may be administered as a tablet and then, within a reasonable period of time, the NK-1 receptor antagonist may be administered either as an oral dosage form such as a tablet or a fast-dissolving oral dosage form. By a "fast dissolving oral formulation" is meant, an oral delivery form which when placed on the tongue of a patient, dissolves within about 10 seconds.
By "reasonable period of time" is meant a time period that is not in excess of about 1 hour. That is, for example, if the COX-2 inhibitor is provided as a tablet, then within one hour, the NK-1 receptor antagonist should be administered, either in the same type of dosage form, or another dosage form which provides effective delivery of the medicament.
WO 99/59635 PCT/G B99/01632 -4- It will be appreciated that the combination of the present invention will be particularly useful in the treatment of a COX-2 mediated disease or disorder. COX-2 mediated diseases and disorders includes inflammatory diseases susceptible to treatment with a non-steroidal anti-inflammatory agent. Such "inflammatory disorders" include rheumatoid arthritis, degenerative joint diseases (osteoarthritis), bursitis, tendinitis, ankylosing spondylitis, gout and synovitis.
The terms "inhibitor of cyclooxygenase-2", "cyclooxygenase-2 inhibitor" and "COX-2 inhibitor" as used herein embrace compounds which selectively inhibit cyclooxygenase-2 over cyclooxygenase-1. Employing the human whole blood COX-1 assay and the human whole blood COX-2 assay described in C. Brideau ct al, Inflanmm. Res. 45: 68-74 (1996), herein incorporated by reference, preferably, the compounds have a cyclooxygenase-2 ICso of less than about 2 tM in the human whole blood COX-2 assay, yet have a cyclooxygenase-1 ICso of greater than about 5 uM in the human whole blood COX-1 assay. Also preferably, the compounds have a selectivity ratio of cyclooxygenase-2 inhibition over cyclooxygenase-1 inhibition of at least 10, and more preferably of at least The resulting selectivity may indicate an ability to reduce the incidence of common NSAID-induced side effects.
As explained in J. Talley, Exp. Opin. Ther. Patents (1997), pp.
55-62, three distinct structural classes of selective COX-2 inhibitor compounds have been identified. One class is the methane sulfonanilide class of inhibitors, of which NS-398, flosulide, nimesulide and L-745,337 are example members.
WO 99/59635 WO 9959635PCT/G B99/0 1632 N HS0 2
CH
3 NH S0 2
CH
3 NHS0 2
CH
3
NO
2 N0 2 0 L-745,337, X =S Flosulide, X 0 NS-398 Nimesulide A second class is the tricyclic inhibitor class, which can be further divided into the sub-classes of tricyclic inhibitors with a central carbocyclic ring (examples include SC-57666, 1, and those with a central monocyclic heterocyclic ring (examples include DuP 697, SC-58125, SC-58635, and 3, 4 and and those withi a central bicyclic heterocyclic ring (examples include 6, 7, 8, 9 and 10). Compounds 3, 4 and 5 are described in U.S. Patent No. 5,474,995.
CH
3
SO
2
NF'
2 S0 2
CH
3
SO
2 SC-57666 0H 3 S0 2
CH
3
SO
2 _a 'N
F
F SC-58 125 DuP 697 WO 99/59635 WO 9959635PCT/G B99/01 632 -6-
CH
3
SO
2
-CF
3 SC-58635
CH
3 SO; CH 3
S'
0
N
CH
3
SO
2
F
CH
3
SO
2
NN
N
7 NH 2 SO 2
FC
NH
2
SO
2
CF
3 CH 3 0 WO 99/59635 PCT/GB99/01632 -7- The third identified class can be referred to as those which are structurally modified NSAIDS, and includes L-761,066 and structure 11 as example members.
CO
2 H N Br& -CI
CH
r
CH
3 L-761,066 0 11 In addition to the structural classes, sub-classes, specific COX-2 inhibitor compound examples, and reference journal and patent publications described in the Talley publication which are all herein incorporated by reference, examples of compounds which selectively inhibit cyclooxygenase-2 have also been described in the following patent publications, all of which are herein incorporated by reference: U.S.
Patent No.'s 5,344,991, 5,380,738, 5,393,790, 5,409,944, 5,434,178, 5,436,265, 5,466,823, 5,474,995, 5,510,368, 5,536,752, 5,550,142, 5,552,422, 5,604,253, 5,604,260, 5,639,780; and International Patent Specification Nos. 94/13635, 94/15932, 94/20480, 94/26731, 94/27980, 95/00501, 95/15316, 96/03387, 96/03388, 96/06840; and International Publication No.'s WO 94/20480, WO 96/21667, WO 96/31509, WO 96/36623, WO 97/14691, WO 97/16435.
Additional COX-2 inhibitor compounds which are included in the scope of this invention include: 0 0 WO 99/59635 WO 9959635PCT/G B99/O 1632
F
0~ N0
S,
16 0 00 0 18 0 19 o 0
'A
0 Cl I v WO 99/59635 WO 9959635PCT/G B99/01 632 -9- I on OH OH Q/O 22 23 0
F
OH
24 0 NHNR
S
0
N
XI
26 Some of the compounds above can also be identified by the following chemical names: 3: 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone; 4: 3-(3 ,4-difluorophenyl)-4-(4-(methylsulfonyl )phenyl 5 ,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3-(3 2-one; 12: 5 dime thyl ethylsulfo nyl )ph enyl prop oxy) -5H-fu ran-2 one; WO 99/59635 WO 9959635PCT/GB99/01 632 10 13: 5 -chlIo ro-3 ethyl sul fonyl )phenyl ethyl -5 -pyri di nyl )pyri dine; 14: 2-(3 ,5-difl uorophenyl)-3-(4-(methylsulfonyl )phenyl)-2-cyclopenten- 1one; 5 -ethyl -5 -methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5Hfuran-2-one; 16: 5 -ethyl -5-m ethyl -4-(4-(methylsul fonyl)phenyl)-3 ,4 -difl u oroph enyl)- 5H-furan-2-one; 17: 3 -thi azolyl)methoxy)-4 ethyl sulfonyl )phenyl ,5 -dim ethyl furan-2-one; 18: 3 -pro pyloxy-4-(4 -(mnethyl sulIfonyl) phe nyl)- 5,5 -dim ethyl 5H-furan -2-one; 19: 3 -cyclopropylethoxy)-5,5 -dim ethyl -4-(4-methylsul fonyl)phenyl)- furan-2 -one; sodium 2-(4-chlorophenyl )-3-(4-(methylsulfonyl)phenyl)-4-oxo-2pentenoate; 21: 3 -(cycl opropylm ethoxy)-5 ,5-dim ethyl -4-(4-(methylsulIfonyl) phenyl furan-2-one;- 22: 3 cyci opropylm ethoxy 5,5-di inethyl ethylsul fonyl )ph e ny)-2 ,5 dihydrofuran-2-ol;, 23: 3 -i sopropoxy- 5,5-d 1imethyl -444-(mnethyls ul fonyl)phen-yl 2,5 dihydrofuran-2-ol; 24: 5,5 -dim ethyl-3-(3 -fluorophenyl)-2-hydroxy-4-(4- 5-chloro-3-(4-(methylsulfonyl)phenyl)-2-(3-pyridinyl)pyridine; 26: 4 -mnethyl -3 -phenyl-4-i soxazolyl)b enzenesulfonamide.
The following publications describe and/or provide methods for making the compounds as indicated: compounds 12, 15, 17, 18, 19 and 2 1, WO 97/14691; compounds 22, 23 and 24, WO 97/16435; compound 20, WO 96/36623; compound 14, U.S. Patent No. 5,536,752; compound 16, U.S.
Patent No. 5,474,995. See Examples herein for compounds 13 and compound 26, U.S. Patent No. 5,633,272.
WO 99/59635 WO 9959635PCT/G B99/O 1632 11 Also incorporated herein by reference are those compounds described in WO 96/41645 as having structural Formula I, shown below, and the definition and preferred definitions and species described therein: 0
R
2 A"
AA
1/ ~0R Particularly preferred compounds of formula include: 5-(4-fluorophenyl [4-(methylsulfonyl)phenyll -3- (tri fl uorom ethyl) pyra zol e; 4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl 1-ph1-enyl-3- (trifi uoromethyl )pyrazole; 4-(5-(4-chlorophenyl)-3-(4-m eth-oxyphen-yl H-p~yrazol- 1yl )benzenesulfonamide; 4-(3 ,5-bis(4-methylphenyl 1H-pyrazol- 1-yl)benzenesulfoinamide;, 4-(5-(4-chlor-ophenyl)-3-pheniyl- 1H-pyrazol-1-yl)benzenesulfonamide; 4-(3 ,5-bis(4-methoxyphenyl)- 1H-pyrazol- 1-yl )benzeinesulfonamide; 4-(5-(4-chlorophenyl)-3-(4-methylphenyl)- 1H-pyr-azol- 1yl )benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(4-nitrophenyl )-1H.-pyrazol- 1yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(5-chloro-2-thienyl)- 1H-pyrazol- 1yl)benzenesulfonamide; 4-(4-chloro-3 ,5-diphenyl- 1H-pyrazol- 1-yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)- 1H-pyrazol- 1yl)benzenesulfonamide; 4-(5-phenyl)-3-(trifluoromethyl)-iHI-pyrazol- 1-yl)benzenesulfonamide; 5-(4-fluorophenyl trifi uorom ethyl 1iH-pyrazol- 1 yl)benzenesulfonamide; WO 99/59635 WO 9959635PCT/GB99/OI 632 12 methoxyphenyl)-3 -(tri fl uorom ethyl) 1 H-pyrazol- 1yl )benzenes ulfonamide; 4-(5-(4-chlorophenyl)-3-(difluoromethyl 1H-pyrazol- 1yl)benzenesulfonamide; -methylphenyl)-3 -(trifluorom ethyl)- 1H-pyrazol-1Iyl )benzenesulfonamide; 4-(4-chloro-5-(4-chlorophenyl)-3-(trifluoromethyl)-iHI-pyrazol- 1yl)benzenesulfonamide; 4-(3-(difluoromethyl)-5-(4-methylphenyl)-1H-pyrazol- 1yl)benzenesulfonamide; 4-(3-(difl uoromethyl )-5-phenyl- 1H-pyrazol- 1 -yl)benzenesulfonamide; 4-(3-(difl uorornethyl)-5-(4-methoxyphenyl)- iH-pyrazol- 1yl )benzenesulfonamide; 4-(3-cyano-5-4-fl uorophenyl)- 1H-pyrazol-1-yI)benzenesulfonarnide; 4-(3-(di fl uorornethyl)-5-(3-fluoro-4-methoxyphenyl)-1IH-pyrazol-1 yl)benzenesulfonamide; 4-(5-(3-fluoro-4-methoxyphenyl )-3-(trifl uorom ethyl)- iHI-pyrazol- 1 yl )benzenesulfonamide; 4-(4-chloro-5-phenyl-iHI-pyrazol- l-yl )benzenesulfonamide;, 4-(5-(4-chlorophenyl)-3-(hydroxyphenyl 1H-pyrazol-1yl)benzenesulfonamide; 4-(5-(4-(N,N-dimethylamino)phenyl)-3-(trifluoromethyl)- 1H-pyrazol- 1yl)benzenesulfonamide; 5-(4-fluorophenyl)-6-(4-(methylsulfonyl )phenyl )spirol2.4lhept-5-ene; 4-(6-(4-fluorophenyl)spiro[2.4lhept-5-en-5-yl)benzenesulfonamide- 6-(4-fluorophenyl)-7-(4-(methylsulfonyl )phenyl)spiro[3 .4loct-6-ene; 5-(3-chloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)spiro hept- 46-(3-chiloro-4-methoxyph enyl )spiro [2.41 he pt-5 yl)benzenesulfonamide; WO 99/59635 WO 9959635PCTIG B9910 1632 13 5-(3 ,5-dichloro-4-methoxyphenyl (m ethyl su lfonylphe nyl)s pi ro 5-43 -chl oro-4-flu oroph enyl ethyl sul fonyl) ph enyl Ospi ro ene; 4(6-(3,4-dichlorophenyl~spiro 2-(3-chloro-4.-fluorophenyl )-4-(4-fluorophenyl)-5-(4m ethyl s ulfonylphenyl)thi azol e; 2 (2-chl orophenyl)-4-(4-fl uoro phenyl 5-(4-m ethyl sulfonyl phe nyl )thi azol e; 5-4441fu orophenyl)-4-(4-m ethyl sul fonyl phenyl -m ethylthi az ole; 4-4-flu oroph-enyl)-5-(4 -m ethyl sulfonyl phenyl)-2-trifl uorom ethylthi azol e; 4-(4-fluorophenylI)-5-(4-m ethyl sul fonylphenyl )-2-(2-thienyl)thi azol e; 4-(4-fluorophenyl)-5 ethyl sulfonylphenyl )-2-benzylani n othiazol e; 4-(4-fl uorophenyl)-5-(4-m ethylsulfonylphenyl)-2-( 1-propylarnino)thI azole;, ,5-dichlorophenoxy)rnethyl )-4-(4-fluorophenyl (m-ethylsulfonyl)phenyl)thiazole; -(4-fl uoroph enyl ethyls ulIfonylIphe nyl )-2-Aniflu ororn ethylithiazol e; 1 -rethylsulfonyl-4-( 1, 1 -dlirethyl-4-4-fl uorophenyl)cyclopenta-2,4-dien-3 yl)benzene; 44-(4-fluorophenyl)- 1, 1-dimethiylcyclopenta-2,4-dien-3yl)benzenesulfonamide; 5-(4-fl uorophenyl ethyl sul fonyl)phenyl)spiro hepta-4 ,6-diene; 4-(6-(4-fluorophenyl)spiro[2 .4lhepta-4,6-dien-5-yl)benzenesulfonamide; 6-(4-fluorophenyl)-2-methoxy-5-(4-(methylsulfonyl)phenyl)-pyridine-3carhonitrile; 2-bromo-6-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-pyridine-3carbonitrile; 6-(4-fluorophenyl ethyl sulfonyl~phenyl)-2-pheny I -pyri dine-3carbonitrile; 4-(2-(4-methyl pyridi n-2-yl )-4-(tri fl uorom ethyl 1H-imidazol 1 yl)benzenesulfonamide;, WO 99/59635 WO 9959635PCT/GB99/01632 14 4424(5 -methyl pyri din -3 -yl)-4-(tri fl uoromethyl 1H-imidazol- 1yl )benzenesulfonamide;- 4-(2-(2-methylpyridin-3-yl)-4-(trifluorornethyl 1H-imidazol-1yl )benzenesulfonarnide; 1-(4-(methylsulfonyl )phenyl)-4-(trifluorom ethyl)- 1H-imidazol-2yl)benzenesulfonarnide; 2 1-(4 ethyls ulfonyl) phenyl)-4-(trifl uorornethyl)- 1H-iinidazol -2yl )pyridine; 2-methyl 1(4 -(rethylsulfonyl)phenyl)-4 -(trif u orom ethyl)- I1H-Irid azol 2-yl)pyridine; 2 -m ethyl -6 1-(4 -(me thyls ulfo iyl )phenyl (tri fl uorornethyl)- 1 H-irn1ida zol 2-yl )pyridine;, 4-(2-(6-methylpyridin-3-yl)-4-(trifl uoromethyl)- 1H-irnidazol-1IyI)benzenesulfonarnide; 2-(3,4-difluorophenyl)- 1-(4-(methylsulfonylI)phenyl)-4-(trifluoromethyl)-1IHimidazole; 42-4-rnethylphenyl tri fl uorornethyl 1H-imidazol- 1yl)benzenesulfonarnide; 2-(4-chlorophenyl 1-(4-(methylsulfonyl )phelnyl )-4-rnethyl- iR-irnidazole; 2-(4-chlorophenyl)- 1444 4-rethyl sul fonyl) phenyl)-4-phenyl 1H-imidazole; 2-(4-chlorophenyl )-4-(4-fluorophenyl)-1-(4-(methylsulfonyl)phenyl)- 1Himidazole; 2-(3-fluoro-4-methoxyphenyl)- 1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl 1H-imidazole; 1-(4-(methyisulfonyl)phenyl)-2-phenyl-4-trifluoromethyl-1H-imidazole; 2-(4-methylphenyl)- 1-(4-(methyls ulfonyl) phenyl) -4-trifl uorom ethyl- I1Himidazole; 4424(3-chl oro-4-m ethyl phenyl) -4-(tri flu oromniethyl 1H-ini da zol- 1 yl )benzenesulfonarnide; 24(3-fl uoro-5 -m ethyl phenyl 1-4-(m ethyl sul fonyl )phenyl (tri fl uorom ethyl 1H-imidazole; WO 99/59635 WO 9959635PCT/G B99/O 1632 15 4-(2-(3-fl uoro-5-methylphenyl trifluoromethyl)- 1H-imidazol- 1yl )benzenesulfonamide;, 2-(3-methylphenyl)- 1-(4(m ethyl sul fonyl) phenyl) -4 -(tri flu orom ethyl 1Himidazole; 4-(2-(3-methylphenyl)-4-(trifluorornethyl)-1H-imidazol- 1yl)benzenesulfonamide; ethyl sul fonyl)phenyl) -24(3-chl orophenyl)-4-(tri fluoromethyl 1Himidazole; 4424(3-chl orophenyl)-4-(trifl uorom ethyl)- 1 H-imi d azol 1 yl)benzenesulfonamide; 4-(2-ph enyl-4-(triflu orom ethyl) 1H-imidazol- Il-yl )benzenesulfonamide; 4- -m ethoxy-3 -chl orophe nyl) -4 -(tri fl uorom ethyl 1H-irnidazol- 1 yl )benzenesulfonamide; 1-allyl-4-(4-fl uorophenyl -(methyls ul fonyl )phenyl tifl uorom ethyl 1H-pyrazole; 441 -ethyl -4-4-fluorophenyl 5- (tri fl uorom ethyl 1 H-pyrazol -3 yl )benzenesulfonami de; N-phenyl-(4-(4-fluorophenyl -(4-(methylsulfonyl)phenyl (trifluoromethyl)- iR-pyrazol- l-yl )acetamide; ethyl (4-(4-fl uorophenyl)-3 ethyl sul fonyl)ph enyl)-5-(tri fl uorom ethyl 1H-pyrazol- l-yl )acetate; 4-(4-fluorophenyl)-3-(4-(methylsulfonyl )phenyl)- 1-(2-phenylethyl)- 1Hpyrazole; 4-441luorophenyl)-3-(4-(methyl sulfo nyl) ph enyl) 1-(2-phenyl ethyl)-5 (trifluoromethylbpyrazole; 1-ethyl-4-(4-fluorophenyl)-3-(4-(methylsulfonyl 1H-pyrazole; 5-(4-fluorophenyl )-4-(4-(methylsulfonyl)phenyl)-2-(trifluoromethyl )-l1Himidazole; 4-(4-(methylsulfonyl)phenyl)-5-(2 -thiophenyl)-2-(trifluorom ethyl)-1IHimidazole; WO 99/59635 WO 9959635PCT/G B99/O 1632 16 5-(4-fluorophenyl)-2-m ethoxy-4-(4-(methylsulfonyl )phenyl)-6- (tri fl uorom ethyl) )pynid ine; 2-ethoxy--5-(4-fluorophenyl )-4-(4-(nethylsulfonyl)phenyl (trifluoromethyl)pyridine; 5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(2-propynyloxy)-6- (trifluoromethyl)pyridine;, 2-brom o-5-44 -fl uorophenylI)-4-(4-(m ethyl sulfonyl)phenyl)-6- (trifluorom ethyl)pyri dine', 4-(2-(3-chloro-4-methoxyphenyl)-4,5-difluorophenyl)benzenesulfonamide; 1 -(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)benzene; 5-difluoromethyl-4-(4-(rnethylsulfonyl )phenyl )-3-phenylisoxazole;, 4-(3-ethyl-5-phenylisoxazol-4-yl )benzenesulfonarnide; 4-(5-difluoromethyl-3-phenylisoxazol-4-yl)benzenesulfoinaride; 445-hydroxym ethyl 3-p henylis oxa zo 1-4 -yl)be nzenesul fonam 1ide; 5-methyl-3 -phienylisoxazol-4-yl)benzenesulfonanide, 14(2-4-flu oroph enyl)cycl opente n- 1 -yl)-4 ethyl sulfonyl)benz ene; 1-(2-4-fluoro-2-rnethyl phenyl)cyclopenteii- 1l-yl )-4-(methylsulfonyl)benzene; 1 -(2-(4-chlorophenyl )cyclopenten- l-yl )-4-(methylsulfonylbenzene; 1-(2-(2,4-dichlorophenyl )cyclopenten- methylsulfonyl )benzene; 1-(2-4-tri fl uorom ethyl phenyl)cycl openten- 1 -yl.)-4-(rnethyl sulfonyl)benzene; 1-(2-(4-methylthiophenyl)cyclopenten- 1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-fluorophenyl )-4,4-dimethylcyclopenten- l-yl)- 4 (methylsulfonyl)benzene; 4-(2-(4-fluorophenyl)-4 ,4-dimethylcyclopenten-1-yl )benzenesulfonamide; 1-(2-(4-chlorophenyl)-4,4-dimethylcyclopenten-1-yl)-4- (methylsulfonyl )benzene; 44(2-(4-chloro phe nyl) -4,4 -di methyl cyclopen ten- I1-yl)benzenes ul fonamid e; 4-(2-(4-fluorophenyl)cyclopenten- l-yl )benzenesulfonarnilde; 4-(2-(4-chlorophenyl)cyclopenten- 1-yl)benzenesulfonamide;, 1 -(2-(4-rnethoxyphenyl )cyclopenten- l-yl )-4-(methylsulfonyl )benzene; 1-(2-(2,3-difluorophenyl )cyclopenten- 1-yl)-4-(methylsulfonyl )benzene; WO 99/59635 WO 9959635PCT/G B99/O 1632 17 44(2-3-fl uor-o-4-methoxyphenyl)cyclopenten- 1-yl)benzenesulfonamide; 1-(2-(3-chloro-4-methoxyphenyl )cyclopenten- 1l-yl)- 4 (methylsulfonyl)benzene,- 442-43 -chiloro-4-41luorophenyl)cycl ope nten- 1 -yl )benzenes ul fonami de; 44(2-(2-methyl pyri din- 5-yl)cycl open te n- I1-yl)benzenesul fonamide; ethyl 2-(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)-2benzyl-acetate; 2-(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)acetic acid; 2-(tert-butyl orophenyl)-5 ethyl su Ifonyl )phenyl)oxazol e; 4-(4-fluorophenyl )-5-(4-(methylsulfonyl )phenyl )-2-phenyloxazole; 4-(4-fl uorophenyl ethyl ethylsulfonyl )phenyl )oxazole;- and 445-(3-fl uoro-4-methoxyphenyl )-2-trifi uorom ethyl -4oxazolyl )benzenesulfonamide; or a pharmaceutically acceptable salt thereof.
NK-1 receptor antagonists of use in the present invention are described in published European Patent Specification Nos. 0 360 390, 0 394 989, 0 429 366, 0 443 132, 0 482 539, 0 512 901, 0 512 902, 0 514 273, 0 514 275, 0 517 589, 0 520 555, 0 522 808, 0 528 495, 0 532 456, 0 533 280, 0 536 817, 0 545 478, 0 577 394, 0 590 152, 0 599 538, 0 610 793, 0 634 402, 0 686 629, 0 693 489, 0 694 535, 0 699 655, 0 699 674, 0 707 006, 0 708 101, 0 714 891, 0 723 959, 0 733 632 and 0 776 893; and in International Patent Specification Nos.
90/05525, 90/05729, 91/09844, 91/18899, 92/01688, 92/06079, 92/12151, 92/15585, 92/17449, 92/20661, 92/20676, 92/21677, 93/00330, 93/0033 1, 93/01159, 93/01165, 93/01169, 93/01170, 93/06099, 93/09116, 93/10073, 93/14113, 93/18023, 93/19064, 93/21155, 9321181, 93/23380, 93/24465, 94/01402, 94/02461, 94/03429, 94/03445, 94/04494, 94/04496, 94/05625, 94/07843, 94/10165, 94/10167, 94/10168, 94/10170, 94/11368, 94/13639, 94/13663, 94/14767, 94/15903, 94/19320, 94/19323, 94/20500, 94/26735, 94/26740, 94/29309, 95/02595, 95/04040, 95/04042, 95/06645, 95/07886, 95/07908, 95/08549, 95/1 1880, 95/140 17, 95/153 11, 95/16679, 95/17382, WO 99/59635 PCT/GB99/01632 18- 95/18124, 95/18129, 95/19344, 95/20575, 95/21819, 96/22525, 95/23798, 95/26338, 95/28418, 95/30674, 95/30687, 96/05193, 96/05203, 96/06094, 96/07649, 96/10562, 96/16939, 96/18643, 96/20197, 96/21661, 96/29304, 96/29317, 96/29326, 96/29328, 96/31214, 96/32385, 96/37489, 97/01553, 97/01554, 97/03066, 97/08144, 97/14671, 97/17362, 97/18206, 97/19084, 97/19942, 97/21702, 97/30055, 97/49710 and 98/01450; and in British Patent Specification Nos. 2 266 529, 2 268 931, 2 269 170, 2 269 590, 2 271 774, 2 292 144, 2 293 168, 2 293 169, 2 302 689 and 2 309 458.
Particularly preferred NK-1 receptor antagonists are those described in European Patent Specification No. 0 577 394, especially compounds of formula 3 4 <X R 4 I R (1)
R
2 N R'
R
or a pharmaceutically acceptable salt thereof, wherein: RI is selected from the group consisting of: Cl-ialkyl, substituted with one or more of the substituents selected from: heterocycle, wherein the heterocycle is selected from the group consisting of: benzimidazolyl, imidazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, pyrazinyl, pyrazolyl, pyridyl, pyrrolyl, WO 99/59635 WO 9959635PCT/G B99/O 1632 19 tetrazolyl, thiadiazolyl, triazolyl, and piperidinyl, and wherein the heterocycle is unsubstituted or substituted with one or more substituent(s) selected from:
CI-
6 alkyl, unsubstituted or substituted with halo, -CF 3
-OCH
3 or phenyl, (11) Cl-6alkoxy, .0 (iii) OXO, (iv) thioxo, (v cyano, (vi -SCH 3 (vii) phenyl, (viii) hydroxy, (ix) tri fl uorom ethyl, (x -(CH 2 1
,-NRR
1 wherein in is 0, 1 or 2, and R 9 and RIO areindependently selected from: hydrogen, (11) C 1.6alkyl, (111) hydroxyCl-6alkyl, and (IV) phenyl, (xi) -NR 9 CORIO, wherein R 9 and RIO are as defined above, and (xii) -CONR 9 RiO, wherein R 9 and Rio are as defined above,
R
2 and R 3 are independently selected from the group consisting of: hydrogen;, Cl.6alkyl
C
2 .6alkenyl, and phenyl; xis WO 99/59635 WO 9959635PCT/G B99/O 1632 20 R4 is z
R
R
5 is phenyl, unsubstituted or substituted with halo;,
R
6
R
7 and W 8 are independently selected from the group consisting of: hydrogen, C1l6alkyl, halo, and
-CF
3 Y is and Z is hydrogen or CI4alkyl; and pharmaceutically acceptable salts thereof'.
Particularly preferred comnpounds of formula are: 1,2,4-triazolo)methyl ,5-bis(trifluoromethyl )benzyloxy)-3(S)phenyl-morpholine; 1,2,4-triazolo)methyl)-2(S )-(3,5-bis(trifluoromethyl)berizyloxy)-3(R)phenyl -morpholine; 4-(3-(5-oxo- 1H,4H-1,2,4-tr-iazolo)methyl)-2(S)-(3,5bis(trifluoromethyl)benzyloxy)-3(S)-phenyl-morpholine; and ,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4-(3-(5-oxo- 1H,4H- 1,2,4-triazolo)methyl)morpholine; or a pharmaceutically acceptable salt thereof.
Further preferred NK-1 receptor antagonists are those described in International (PCT) Patent Specification No. WO 95/18124, especially compounds of formula (II) and pharmaceutically acceptable salts thereof: WO 99/59635 PCT/GB99/01632 -21-
A
l O O
N
R
6
A
3
(II)
wherein: A' is fluorine or CF 3
A
2 is fluorine or CF 3 A is fluorine or hydrogen;
R
6 is a 5-membered or 6-membered heterocyclic ring containing 2 or 3 nitrogen atoms optionally substituted by =S or a C3-4alkyl group, and optionally substituted by a group of the formula ZNR 7 R8 where Z is Ci-calkylene or C3-6cycloalkylene;
R
7 is hydrogen, C1- 4 alkyl, C3-7cycloalkyl or C37cycloalkylC1-4alkyl, or C2- 4 alkyl substituted by C1-4alkoxy or hydroxyl;
R
8 is hydrogen, C1i 4 alkyl, C3-7cycloalkyl or C3-7cycloalkylC1- 4 alkyl, or C2- 4 alkyl substituted by one or two substituents selected from C1- 4 alkoxy, hydroxyl or a 4, 5 or 6 membered heteroaliphatic ring containing one or two heteroatoms selected from N, O and S; or R 7
R
8 and the nitrogen atom to which they are attached form a heteroaliphatic ring of 4 to 7 ring atoms, optionally substituted by a hydroxy group, and optionally containing a double bond, which ring may optionally contain an oxygen or sulphur ring atom, a group S(0) or S(0)2 or a second nitrogen atom which will be part of a NH or NR c moiety where Rc is C1.
4 alkyl optionally substituted by hydroxy or C1-4alkoxy; or R 7
R
8 and the nitrogen atom to which they are attached form a non-aromatic azabicyclic ring system of 6 to 12 ring atoms; WO 99/59635 PCT/GB99/01632 -22or Z, R 7 and the nitrogen atom to which they are attached form a heteroaliphatic ring of 4 to 7 ring atoms which may optionally contain an oxygen ring atom; X is an alkylene chain of 1 to 4 carbon atoms optionally substituted by oxo; and Y is a C1.4alkyl group optionally substituted by a hydroxyl group; with the proviso that if Y is Ci14alkyl, R 6 is susbstituted at least by a group of formula ZNR 7 R8 as defined above.
Particularly preferred compounds of formula (II) include: 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(5-(dimethylamino) methyl-1,2,3-triazol-4-yl)methyl-3-(S)-phenylmorpholine; 2-(R)-(l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(5-(dimethylamino) methyl- 1,2,3-triazol-4-yl)methyl-3-(S)-(4-fluorophenyl)morpholine; 2-(R)-(1-(S)-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethoxy)-3-(S)-(4fluorophenyl)-4-(1,2,4-triazol-3-yl)methylmorpholine; and pharmaceutically acceptable salts thereof.
Further preferred NK-1 receptor antagonists are those described in European Patent Specification No. WO 95/23798, especially compounds of formula (III):
R
G
R
3 X Y
R
z R (III) R 2 N P A S 13 R12 B R or a pharmaceutically acceptable salt thereof, wherein:
R
2 and R 3 are independently selected from the group consisting of: hydrogen, C1.6alkyl, WO 99/59635 PCT/G B99/01632 -23- C2-6alkenyl, and phenyl;
R
6
R
7 and R s are independently selected from the group consisting of: hydrogen, Cil6alkyl, fluoro, chloro, bromo, iodo, and
-CF
3
R
11
R
12 and R 13 are independently selected from the group consisting of: fluoro, chloro, bromo, and iodo; A is unsubstituted 1-6alkyl; B is selected from the group consisting of: H X X N-N X X HH N-N N-N N-N N s 0 0 iN N N X H N-H X H X N-N H X N-N N-N N-N N /x X X N S N
N
X H X N-N N N-N N SN N N X X WO 99/59635 WO 9959635PCT/G B99/0 1632 x
N
H
N
x 24
IN
x
H
/-N
N0 x
N
H
H
N
K N p is 0 or 1; X is selected from: -PO(OH)0- e wherein M' is a pharmaceutically acceptable monovalent counterion, -PO(0-) 2 *2M+, -PO(0-) 2
D
2 wherein D 2 is a pharmaceutically acceptable divalent counterion, -CH(R4)-PO(OH)O- wherein R4 is hydrogen Or CI-3alkyl, 2
-CO-CH
2
CH
2 -C0 2
-CH(CH
3
)-O-CO-R
5 wherein R 5 is selected from the group consisting of: WO 99/59635 WO 9959635PCT/G B99/O 1632 25 H 2 M (ii) 0 OH2M 0 GO,, M+ 02' NH3 (vi) 0-C0 2
'M
CO0 M+ C0,; M (Vii) ;and Y is Z is hydrogen or Cl-6alkyl; and pharmaceutically acceptable salts thereof.
Particularly preferred compounds of formula (III) include: 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(3-(5-oxo- 1H,4H-1,2,4-triazolohriethyl)morpholine N-oxide; WO 99/59635 WO 9959635PCT/G B99/O 1632 26 ,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(3-(4- (ethoxycarbonyloxy- 1-ethyl)-5-oxo- 11-- 1,2,4triazolo)methyl)morpholine; ,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4fluorophenyl)-4-(3-(4-monophosphoryl-5-oxo- 1H-1,2 ,4triazolo)methyl)morpholine; 1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4fluorophenyl)-4-(3-( 1-monophosphoryl-5-oxo-1H- 1,2,4triazolo)rnethyl)morpholine; 1-(R)-(3,5-bis(trifluoron-ethyl)phenyl)ethoxy)-3-(S)-(4fluorophenyl )-4-(3-(2-monophosphoryl-5-oxo- 1H- 1,2,4triazolo)methyl )morpholine; 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4fluorophenyl )-4-(3-(5-oxyphosphoryl- 11-- 1,2,4triazolo)methyl)morpholine; ,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4fluorophenyl)-4-(3-( 1-monophosphoryI -5-oxo-4H- 1,2,4triazolo)methyl)rnorpholine; and pharmaceutically acceptable salts thereof.
Further preferred NK-1 receptor antagonists are those described in International Patent Specification No. WO 97/49710, especially compounds of formula (LV): R R k
X//
(IV)
N 3~
H
wherein WO 99/59635 PTGB9O 3 PCT/G B99/01632 27 RI represents hydrogen, hydroxy, C1-6alkyl, C2-6alkenyl, C3-7CYCloalkyl, C3- 7 cycloalkylC i-4alkyl, C 1-6alkoxy, fluoroC 1.6alkoxy, CI-6alkoxyCl-4alkyl, C l-6alkoxyC l4alkoxy, fluoroC l6alkoxyC 1-4alkyl, C2-6alkenyloxy, C3-7cycloalkoxy, C3.7cycloalkylC l-alkoxy, phenoxy, benzyloxy, cyano, halogen, NRaRb, SRa, SORa, SO 2 Ra, OSO 2 Ra, NRaCOR14, CORa, CO 2 Ra or CONRaRb where Ra and Rb each independently represent hydrogen, C1-4alkyl or fluoroCl-4alkyl;
R
2 represents hydrogen, halogen, Cl-6alkyl or C1l6alkoxy; or RI and R 2 may be joined together such that there is formed a 5- or 6-membered saturated or unsaturated ring containing one or two atoms selected from nitrogen, oxygen and sulphur, which ring is optionally substituted by a group selected from C14alkyl, CF 3 =0 Or=S R3 represents hydrogen, halogen, C1b6alkyl, fluoroCI-6alkyl, C 1-6alkoxy, fi uoroC 1-6alkoxy, C3-7CYCloalkyl, C3-7cycloalkylC l4alkyl, cyano, SRa, SORa, SO 2 Ra, NRaRb, NRaCOR14, CORa, CO 2 Ra, CONRaRb or C1- 4 alkyl substituted by cyano, CO 2 Ra or CONRaRb where Ra and Rb are as previously defined; R4 represents hydrogen, halogen, CI.6alkyl, Cl-6alkoxy, CF 3
OCF
3 N0 2 CN, SRa, SORa, SO 2 Ra, CO 2 Ra, CONRaRb, C2-6alkenyl, C2-6alkynyl or C1 4 alkyl substituted by Cl4alkoxy, where Ra and Rb are as previously defined; and the broken line represents an optional double bond; and pharmaceutically acceptable salts thereof.
Particularly preferred compounds of formula (IV) include: 3 R,5R,6S)-3-(2-methoxy-5-(trifluoromethoxy)phenyl)-6-phenyl- 1-oxa-7aza-spiro decane; (3R ,5R ,6S)-3-(2-methoxy-5-(trifluoromethyl)phenyl )-6-phenyl-1-oxa-7-azaspiro [4.51 decane;, (3R, 5R ,6S)-7 -benzyl-3 2 -methoxy-5-(trifluor omethoxy)phenyl] -6-phenyl- 1 oxa-7 -aza-spiro [4.51ldecane; (3R, 5R ,6S)-3 -(2-methoxy-5-tri fluorom ethoxyphenyl )-6-phenyl- I1-oxa-7 -aza- WO 99/59635 WO 9959635PCT/G B99/0 1632 28 (3R, 5R,6S)-3,6-bis(phenyl )-1I-oxa-7-aza-spiro [4.51 decane; ,6S)-7-benzyl-3-(2-methoxy-5-trifluoromethoxyphenyl )-6-phenyl- 1oxa-7-aza-spiro decane; 5R*,6' 3(-ehxpenl--hnlloa7 (phenylmethoxycarbonyl)aza-spiro[4.51 decane; (3R,5R,6S)-3-(2-methoxyphenyl)-6-phenyl- 1-oxa-7-aza-spiro [4.51 decane; (3S, 5R,6S)-3-(2-cyclopropoxy-5-(trifluoromethoxy)phenyl)-6-phenyl- 1 -oxa- 7-aza-spiro decane; (3R, 5R,6S)-3-[2-cyclopropoxy-5-(trifluoromethoxy)phenyl -6-phenyl-l1-oxa- 7-aza-spiro decane; (3S, 5R [2-cyclopropoxy-5-(trifluoromethyl )phenyl] -6-phenyl- 1 -oxa-7aza-spiro decane; and pharmaceutically acceptable salts thereof.
Another class of NK-1 receptor antagonists of use in the present invention is that described in European Patent Specification No.
0 436 334, i.e. compounds of formula R 2
(V)
1 6
R
or a pharmaceutically acceptable salt thereof, wherein Y is (CH 2 wherein n is an integer from 1 to 4, and wherein any one of the carbon-carbon single bonds in said (CH 2 )n may optionally be replaced by a carbon-carbon double bond, and wherein any one of the carbon atoms of said (CH 2 )n may optionally be substituted with R 4 and wherein any one of the carbon atoms of said (CI- 2 )n may optionally be substituted with R 7 WO 99/59635 PCT/GB99/01632 -29- Z is (CH 2 )m wherein m is an integer from 0 to 6, and wherein any one of the carbon-carbon single bonds of (CH2)m may optionally be replaced by a carbon-carbon double bond or a carbon-carbon triple bond, and any one of the carbon atoms of said (CH 2 )m may optionally be substituted with R8;
R
1 is hydrogen or Clisalkyl optionally substituted with hydroxy, C1i 4 alkoxy or fluoro;
R
2 is a radical selected from hydrogen, C 1 6 straight or branched alkyl, C3-7cycloalkyl wherein one of the CH 2 groups in said cycloalkyl may optionally be replaced by NH, oxygen or sulphur; aryl selected from phenyl and naphthyl; heteroaryl selected from indanyl, thienyl, furyl, pyridyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, tetrazolyl and quinolyl; phenyl-C26alkyl, benzhydryl and benzyl, wherein each of said aryl and heteroaryl groups and the phenyl moieties of said benzyl, phenyl C2-6alkyl and benzhydryl may optionally be substituted with one or more substituents independently selected from halo, nitro, C 1 -6 alkyl, Ci-lalkoxy, trifluoromethyl, amino, C.-6alkylamino, Ci.-alkyl-O-CO, Ci- 6 alkyl-O-CO- Ci-6alkyl, C1-6alkyl-CO-O, Ci-6alkyl-CO-C-.6alkyl-O-, CI-6alkyl-CO, Ci-6alkyl-CO-C -6alkyl-, di-Ci-alkylamino, -CONH-Ci-6alkyl, Cl-6alkyl-CO-NH-Cl-ealkyl, -NHCOH and -NHCO-Ci- 6 alkyl; and wherein one of the phenyl moieties of said benzhydryl may optionally be replaced by naphthyl, thienyl, furyl or pyridyl;
R
5 is hydrogen, phenyl or C1l6alkyl; or R 2 and R 5 together with the carbon to which they are attached, form a saturated ring having from 3 to 7 carbon atoms wherein one of the
CH
2 groups in said ring may optionally be replaced by oxygen, NH or sulfur;
R
3 is aryl selected from phenyl and naphthyl; heteroaryl selected from indanyl, thienyl, furyl, pyridyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, tetrazolyl and quinolyl; and cycloalkyl having 3 to 7 WO 99/59635 PCT/GB99/01632 carbon atoms wherein one of the (CH 2 groups in said cycloalkyl may optionally be replaced by NH, oxygen or sulphur; wherein each of said aryl and heteroaryl groups may optionally be substituted with one or more substituents, and said C3.7cycloalkyl may optionally be substituted with one or two substituents, each of said substituents being independently selected from halo, nitro, Cl-6alkyl, Ci-6alkoxy, trifluoromethyl, amino, Ci-6alkylamino, -CO-NH- C1.6alkyl, CI-6alkyl-CO-NH-C 1.alkyl, -NHCOH and -NHCO-Ci-6alkyl;
R
4 and R 7 are each independently selected from hydroxy, halogen, halo, amino, oxo, cyano, methylene, hydroxymethyl, halomethyl, Ci-6alkylamino, di-Ci-6alkylamino, Ci.-alkoxy, Cl-6alkyl-O-CO, C1-6alkyl-O-CO-C.-6alkyl, Ci.6alkyl-CO-O, Ci-6alkyl-CO-Ci-6alkyl-O-, Cil.alkyl-CO-, Ci.6alkyl-CO-CI.-alkyl, and the radicals set forth in the definition of R 2
R
6 is -NHCOR 9
-NHCH
2
R
9
SO
2
R
8 or one of the radicals set forth in any of the definitions of R 2
R
4 and R 7
R
8 is oximino (=NOH) or one of the radicals set forth in any of the definitions of R 2
R
4 and R 7
R
9 is C1.6alkyl, hydrogen, phenyl or phenylCi6alkyl; with the proviso that when m is 0, R 8 is absent, when R 4
R
6
R
7 or
R
8 is as defined in R 2 it cannot form together with the carbon to which it is attached ,a ring with R5, and when R 4 and R 7 are attached to the same carbon atom, then either each of R 4 and R 7 is independently selected from hydrogen, fluoro and C1-6alkyl, or R 4 and R 7 together with the carbon to which they are attached, for a C3- 6 saturated carbocyclic ring that forms a spiro compound with the nitrogen-containing ring to which they are attached.
A particularly preferred compound of formula is (2S,3S)-cis-3-(2methoxybenzylamino)-2-phenylpiperidine; or a pharmaceutically acceptable salt thereof.
WO 99/59635 PCT/GB99/01632 -31 Another class of NK-1 receptor antagonists of use in the present invention is that described in International Patent Specification No. WO 93/21155, i.e. compounds of formula (VI): N CH-R'
(VI)
12
R
R 3
R
or a pharmaceutically acceptable salt thereof, wherein radicals R are phenyl radicals optionally 2- or 3-substituted by a halogen atom or a methyl radical; RI is optionally substituted phenyl, cyclohexadienyl, naphthyl, indenyl or optionally substituted heterocycle;
R
2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, optionally substituted alkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino;
R
3 is optionally 2-substituted phenyl;
R
4 is OH or fluorine when R 5 is H; or R 4 and R 5 are OH or R 4 and R 5 together form a bond.
A particularly preferred compound of formula (VI) is (3aS, 4S, 7aS)- 7,7-diphenyl-4-(2-methoxyphenyl)-2-[(2S)-(2-methoxyphenyl)propionyl] perhydroisoindol-4-ol; or a pharmaceutically acceptable salt thereof.
Another class of NK-1 receptor antagonists of use in the present invention is that described in European Patent Specification No.
0 591 040, i.e. compounds of formula (VII): R
Q
Ar-T-CO-N-CH 2
-C-CH
2
-CH
2 -Am A (VII) Ar' wherein WO 99/59635 PCT/GB99/01632 -32- Ar represents an optionally substituted mono-, di- or tricyclic aromatic or heteroaromatic group; T represents a bond, a hydroxymethylene group, a C1.4alkoxymethylene group or a Ci-salkylene group; Ar' represents a phenyl group which is unsubstituted or substituted by one or more substituents selected from halogen, preferably chlorine or fluorine, trifluoromethyl, C1.
4 alkoxy, C1-4alkyl where the said substituents may be the same or different; a thienyl group; a benzothienyl group; a naphthyl group; or an indolyl group; R represents hydrogen, C1- 4 alkyl, o-C1-4alkoxyCi.
4 alkyl, or co-C2.4alkanoyloxyC2- 4 alkyl; Q represents hydrogen; or Q and R together form a 1,2-ethylene, 1,3-propylene or 1,4butylene group; Am represents the radical in which X 1
X
2 and X 3 together with the nitrogen atom to which they are attached, form an azabicyclic or azatricyclic ring system optionally substituted by a phenyl or benzyl group; and A- represents a pharmaceutically acceptable anion.
A particularly preferred compound of formula (VII) is (3,4-dichlorophenyl)-1-[(3-isopropoxyphenyl)acetyl]-3-piperidinyl] ethyl] -4phenyl-1-azabicyclo[2,2,2]octane; or a pharmaceutically acceptable salt, especially the chloride, thereof.
Another class of NK-1 receptor antagonists of use in the present invention is that described in European Patent Specification No.
0 532 456, i.e. compounds of formula (VIII): WO 99/59635 PCT/GB99/01632 -33- R -N X R 4
(VIII)
R
X
or a pharmaceutically acceptable salt thereof, wherein
R
I represents an optionally substituted aralkyl, aryloxyalkyl, heteroaralkyl, aroyl, heteroaroyl, cycloalkylcarbonyl, aralkanoyl, heteroarylalkanoyl, aralkoxycarbonyl or arylcarbamoyl group or the acyl group of an a-amino acid optionally N-substituted by a lower alkanoyl or carbamoyl-lower alkanoyl group;
R
2 represents cycloalkyl or an optionally substituted aryl or heteroaryl group;
R
3 represents hydrogen, alkyl, carbamoyl or an alkanoyl or alkenoyl group optionally substituted by carboxy or esterified or amidated carboxy;
R
4 represents an optionally substituted aryl group or an optionally partially saturated heteroaryl group; Xi represents methylene, ethylene, a bond, an optionally ketalised carbonyl group or an optionally etherified hydroxymethylene group;
X
2 represents alkylene, carbonyl or a bond; and
X
3 represents carbonyl, oxo-lower alkyl, oxo(aza)-lower alkyl, or an alkyl group optionally substituted by phenyl, hydroxymethyl, optionally esterified or amidated carboxy, or (in other than the a-position) hydroxy.
A particularly preferred compound of formula (VIII) is 4S*)-2benzyl-l-(3,5-dimethylbenzoyl)-N-(4-quinolinylmethyl)-4-piperidineamine; or a pharmaceutically acceptable salt thereof.
Another class of NK-1 receptor antagonists of use in the present invention is that described in European Patent Specification No.
0 443 132, i.e. compounds of formula (IX) WO 99/59635 PCT/GB99/01632 -34-
CH
2 R -Y-A-N CONHCHCON (IX) R4 or a pharmaceutically acceptable salt thereof, wherein
R
1 is aryl, or a group of the formula: z X is CH or N; and Z is O or N-R 5 in which R 5 is hydrogen or lower alkyl;
R
2 is hydroxy or lower alkoxy;
R
3 is hydrogen or optionally substituted lower alkyl;
R
4 is optionally substituted ar(lower)alkyl; A is carbonyl or sulfonyl; and Y is a bond or lower alkenylene.
A particularly preferred compound of formula (IX) is the compound of formula (IXa)
HO
0 I I (IXa) or a pharmaceutically acceptable salt thereof.
WO 99/59635 PCT/G B99/01632 Another class of NK-1 receptor antagonists of use in the present invention is that described in International Patent Specification No. WO 92/17449, i.e. compounds of the formula (X)
H
N R 2
H
(X)
or a pharmaceutically acceptable salt thereof, wherein
R
1 is aryl selected from indanyl, phenyl and naphthyl; heteroaryl selected from thienyl, furyl, pyridyl and quinolyl; and cycloalkyl having 3 to 7 carbon atoms, wherein one of said carbon atoms may optionally be replaced by nitrogen, oxygen or sulfur; wherein each of said aryl and heteroaryl groups may optionally be substituted with one or more substituents, and said C3.7cycloalkyl may optionally be substituted with one or two substituents, said substituents being independently selected from chloro, fluoro, bromo, iodo, nitro, Ci.ioalkyl optionally substituted with from one to three fluoro groups, Ci-ioalkoxy optionally substituted with from one to three fluoro groups, amino, Ci-ioalkyl-S-, Ciioalkyl-S(O)-, Ci-ioalkyl-SO2-, phenyl, phenoxy, Cl-o1alkyl-SO2NH-, Ci-loalkyl-SO 2 NH-Ci-ioakyl-, Ci-ioalkylamino-diCiioalkyl-, cyano, hydroxy, cycloalkoxy having 3 to 7 carbon atoms, C1.6alkylamino, Cl-6dialkylamino, HC(O)NH- and Cl-ioalkyl-C(O)NH-; and
R
2 is thienyl, benzhydryl, naphthyl or phenyl optionally substituted with from one to three substituents independently selected from chloro, bromo, fluoro, iodo, cycloalkoxy having 3 to 7 carbon atoms, Cl-loalkyl optionally substituted with from one to three fluoro groups and Ci-loalkoxy optionally substituted with from one to three fluoro groups.
A particularly preferred compound of formula is (2S,3S)-3-(2methoxy-5-trifluoromethoxybenzyl)-amino-2-phenylpiperidine; or a pharmaceutically acceptable salt thereof.
WO 99/59635 PCT/GB99/01632 -36- Another class of NK-1 receptor antagonists of use in the present invention is that described in International Patent Specification No.
WO 95/08549, i.e. compounds of formula (XI)
R
2
(CH
2
H
N N -3 H
R"
R
(XI)
or a pharmaceutically acceptable salt thereof, wherein
R
1 is a C1- 4 alkoxy group;
R
2 is 6
_N
N
N-N
R
3 is a hydrogen or halogen atom;
R
4 and R 5 may each independently represent a hydrogen or halogen atom, or a C1-4alkyl, C1-4alkoxy or trifluoromethyl group;
R
6 is a hydrogen atom, a C1-4alkyl, (CH2)mcyclopropyl, -S(O)nC1-4alkyl, phenyl, NR7R8, CH 2 C(O)CF3 or trifluoromethyl group;
R
7 and R 8 may each independently represent a hydrogen atom, or a C1.4alkyl or acyl group; x represents zero or 1; n represents zero, 1 or 2; and m represents zero or 1.
Particularly preferred compounds of formula (XI) are tetrazol-l-yl-benzyl)-([2S,3S]-2-phenyl-piperidin-3-yl)-amine; and [2- WO 99/59635 WO 9959635PCT/G B99/O1 632 37 m ethoxy-5 -tri flu orom ethyl -tetrazol 1 -yl)-benzyll-( [2S,3S1 -2-phenylpiperidin-3-yl)-amine; or a pharmaceutically acceptable salt thereof.
Another class of tachykinin antagonists of use in the present invention is that described in International Patent Specification No.
WO 95/14017, i.e. cornpounds of formula (XII) R
R
NH R (CO)p 1 1 (XII) or a pharmaceutically acceptable salt thereof, wherein i11 is zero, 1; 2 or 3; n is zero or 1; o is zero,l1or 2; p) is zero or 1; R is phenyl, 2- or 3-indolyl, 2- or 3-indolinyl, benzothienyl, benzofuranyl, or naphthyl; which R groups may be substituted with one or two halo, Cl-3alkoxy, trifluorom ethyl, C1- 4 alkyl, phenyl-CI.3alkoxy, or C1l4alkanoyl groups; R1 is trityl, phenyl, diphenylmethyl, phenoxy, phenylthio, piperazinyl, piperidinyl, pyrrolidinyl, morpholinyl, indolinyl, indolyl, benzothienyl, hexamethyleneiminyl, benzofuranyl, tetrahydropyridinyl, quinolinyl, isoquinolinyl, reduced quinolinyl, reduced isoquinolinyl, phenyl-(C I.
4 alkyl)-, phenyl-(CI-4alkoxy)-, quinolinyl-(C 1-4alkyl)-, isoquinolinyl-(C i4alkyl)-, reduced quniolinyl-(C 1-4alkyl)-, reduced isoqui nolinyl-(CIl4alkyl)-, benzoyl-(C 1 -3alkyl C1-4alkyl, or -NH-CH 2 any one of which RI groups may be substituted with halo, Ci 4 alkyl, Cl4alkoxy, trifl uorom ethyl, amino, CI- 4 alkylamino, di(CI- 4 alkyl)amino, or C2- 4 alkanoylamino; WO 99/59635 WO 9959635PCT/G B99/O1 632 38 or any one of which RI groups may be substituted with phenyl, piperazinyl, C3-8CYCloalkyl, benzyl, CI-4alkyl, piperidinyl, pyridinyl, pyrimidinyl, C2.alkanoylamino, pyrrolidinyl, C2-6alkanoyl, or C 1-4alkoxycarbonyl; any one of which groups may be substituted with halo, CI- 4 alkyl, C i-4alkoxy, trifluoromethyl, amino, C 14alkylamino, di(C 1-4alkyl)amino, or C2-4alkanoylamino; or R 1 is amino, a leaving group, hydrogen, Cl-4alkylamino, or di(C -4alkyl)amino;,
R
5 is pyridyl, anilino-(Clv3alkyl)-, or anilinocarbonyl;
R
2 is hydrogen, C l4alkyl, C l-alkylsulfonyl, carboxy-(CI-3alkyl Cl-3alkoxycarbonyl-(Cl-3alkyl)-, or -CO-R 6
R
6 is hydrogen, C 1 4 alkyl, C 1.3haloalkyl, phenyl, C1l3alkoxy, C1.3hydroxyalkyl, amino, Cl-4alkylamino, di(CI-4alkyl)amino, or -(CH2)q-R 7 q is zero to 3;
R
7 is carboxy, C 1 4alkoxycarbonyl, C l4alkylcarbonyloxy, amino, C -4alkylamino, di(C 1 4 alkyl )amino, C 1-6alkoxycarbonylamino, or phenoxy, phenylthio, piperazinyl, piperidinyl, pyrrolidinyl, morpholinyl, indolinyl, indolyl, benzothienyl, benzofuranyl, quinolinyl, phenyl-(C 1-4alkyl quinolinyl-(C I 4 alkyl isoquinolinyl-(C l4alkyl reduced quinolinyl- (Cl-4alkyl)-, reduced isoquinolinyl-(C I 4 alkyl)-, benzoyl-C 1-3alky1; any one of which aryl or heterocyclic R 7 groups may be substituted with halo, trifluoromethyl, C1I4alkoxy, CI-4alkyl, amino, Cl-4alkylamino, di(CI-4alkyl)amino, or C2-4alkanoylamino; or any one of which R 7 groups may be substituted with phenyl, piperazinyl, C3.8cycloalkyl, benzyl, piperidinyl, pyridinyl, pyrimidinyl, pyrrolidinyl, C2-6alkanoyl, or C l4alkoxycarbonyl; any of which groups may be substituted withi halo, trifluoromethyl, amino, CI- 4 alkoxy, CI- 4 alkyl, CI-4alkylamino, di(CI- 4 alkyl)amino, or C24alkanoylamino;,
R
8 is hydrogen or Cl-6alkyl; WO 99/59635 PCT/GB99/01632 -39-
R
3 is phenyl, phenyl-(Ci-6alkyl)-, Ca.scycloalkyl, Cs-scycloalkenyl, Cl-alkyl, naphthyl, C2.8alkenyl, or hydrogen; any one or which groups except hydrogen may be substituted with one or two halo, C1.3alkoxy, Ci-3alkylthio, nitro, trifluoromethyl, or C1.3alkyl groups; and
R
4 is hydrogen or C-l3alkyl; with the proviso that if R 1 is hydrogen or halo, R 3 is phenyl, phenyl-(C -6alkyl)-, C3-8cycloalkyl, Cs-scycloalkenyl, or naphthyl.
A particularly preferred compound of formula (XII) is methoxybenzyl)acetylamino]-3-(1H-indol-3-yl)-2-[N-(2-(4-piperidin-1yl)piperidin-l-yl)acetylamino]propane; or a pharmaceutically acceptable salt thereof.
The preferred compounds of formulae (II) and (III) will have the 2- and 3-substituents on the morpholine ring in the cis arrangement, the preferred stereochemistry being as shown in the following general formula: O O N 2
R
Where the benzyloxy moiety is a-substituted, the preferred stereochemistry of the o-carbon is either when the substituent is an alkyl methyl) group or when the substituent is a hydroxyalkyl hydroxymethyl) group.
The preferred compounds of formula (IV) will have the stereochemistry of the 5- and 6-positions as shown below Where the optional double bond shown in formula (IV) is absent, the WO 99/59635 PCT/G B99/01632 40 particularly preferred compounds will have the stereochemistry of the 3-position as shown below 3- H
H
Unless otherwise defined herein, suitable alkyl groups include straight-chained and branched alkyl groups containing from 1 to 6 carbon atoms. Typical examples include methyl and ethyl groups, and straightchained or branched propyl and butyl groups. Particular alkyl groups are methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl and tert-butyl.
Unless otherwise defined herein, suitable alkenyl groups include straight-chained and branched alkenyl groups containing from 2 to 6 carbon atoms. Typical examples include vinyl and allyl groups.
Unless otherwise defined herein, suitable alkynyl groups include straight-chained and branched alkynyl groups containing from 2 to 6 carbon atoms. Typical examples include ethynyl and propargyl groups.
Unless otherwise defined herein, suitable cycloalkyl groups include groups containing from 3 to 7 carbon atoms. Particular cycloalkyl groups are cyclopropyl and cyclohexyl.
Unless otherwise defined herein, suitable aryl groups include phenyl and naphthyl groups.
A particular aryl-Cl 6 alkyl, e.g. phenyl-Cl.-alkyl, group is benzyl.
Unless otherwise defined herein, suitable heteroaryl groups include pyridyl, quinolyl, isoquinolyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyranyl, furyl, benzofuryl, thienyl, benzthienyl, imidazolyl, oxadiazolyl and thiadiazolyl groups.
WO 99/59635 PCT/G B99/0 632 -41- The term "halogen" as used herein includes fluorine, chlorine, bromine and iodine.
Suitable pharmaceutically acceptable salts of the NK-1 receptor antagonists of use in the present invention include acid addition salts which may, for example, be formed by mixing a solution of the compound with a solution of a pharmaceutically acceptable non-toxic acid such as hydrochloric acid, fumaric acid, maleic acid, succinic acid, acetic acid, citric acid, tartaric acid, carbonic acid, phosphoric acid or sulphuric acid. Salts of amine groups may also comprise the quaternary ammonium salts in which the amino nitrogen atom carries an alkyl, alkenyl, alkynyl or aralkyl group. Where the compound carries an acidic group, for example a carboxylic acid group, the present invention also contemplates salts thereof, preferably non-toxic pharmaceutically acceptable salts thereof, such as the sodium, potassium and calcium salts thereof.
The compounds of use in this invention may have one or more chiral centers and the present compounds may occur as racemates, racemic mixtures and as individual diasteriomers or enantiomers with all such isomeric forms and mixtures thereof being included within the scope of this invention. Furthermore, some of the crystalline forms for compounds of the present invention may exist as polymorphs and as such are intended to be included in the present invention. In addition, some of the compounds of the instant invention may form solvates with water or common organic solvents. Such solvates and hydrates, as well as anhydrous compositions, are encompassed within the scope of this invention. Some of the compounds described herein may contain olefinic double bonds, and unless specified otherwise, are meant to include both E and Z geometric isomers.
The COX-2 inhibitors that may be used with this invention encompass all pharmaceutically acceptable salt forms of the compounds.
Examples of such salt forms of COX-2 inhibitors include but are not limited to salts derived from inorganic bases including aluminum, WO 99/59635 PCT/G B99/01632 -42 ammonium, calcium, copper, ferric, ferrous, lithium, magnesium, manganic salts, manganous, potassium, sodium, zinc, and the like.
Particularly preferred are the ammonium, calcium, magnesium, potassium, and sodium salts. Salts derived from pharmaceutically acceptable organic non-toxic bases include salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines, and basic ion exchange resins, such as arginine, betaine, caffeine, choline, N,N-dibenzylethylenediamine, diethylamine, 2-diethylaminoethanol, 2-dimethylaminoethanol, ethanolamine, ethylenediamine, N-ethylmorpholine, N-ethylpiperidine, glucamine, glucosamine, histidine, hydrabamine, isopropylamine, lysine, methylglucamine, morpholine, piperazine, piperidine, polyamine resins, procaine, purines, theobromine, triethylamine, trimethylamine, tripropylamine, tromethamine, and the like.
The instant pharmaceutical combination comprising a COX-2 inhibitor in combination with a NK-1 receptor antagonist includes administration of a single pharmaceutical dosage formulation which contains both the COX-2 inhibitor and the NK-1 receptor antagonist, as well as administration of each active agent in its own separate pharmaceutical dosage formulation. Where separate dosage formulations are used, the COX-2 inhibitor and the NK-1 receptor antagonist can be administered at essentially the same time, concurrently, or at separately staggered times, i.e, sequentially. The instant pharmaceutical combination is understood to include all these regimens. Administration in these various ways are suitable for the present invention as long as the beneficial pharmaceutical effect of the COX-2 inhibitor and the NK-1 receptor antagonist are realized by the patient at substantially the same time. Such beneficial effect is preferably achieved when the target blood level concentrations of each active drug are maintained at substantially the same time. It is preferred that the COX-2 inhibitor and the NK-1 receptor antagonist be co-administered concurrently on a once-a-day WO 99/59635 PCT/GB99/01632 43 dosing schedule; however, varying dosing schedules, such as the COX-2 inhibitor once, twice or more times per day and the NK-1 receptor antagonist once per day, is also encompassed herein. A single oral dosage formulation comprised of both the COX-2 inhibitor and the NK-1 receptor antagonist is preferred. A single dosage formulation will provide convenience for the patient, which is an important consideration especially for patients who already have an inflammatory disorder such as rheumatoid arthritis and may be in need of multiple medications.
The term "therapeutically effective amount" is intended to mean that amount of a drug or pharmaceutical agent that will elicit the biological or medical response of a tissue, a system, animal or human that is being sought by a researcher, veterinarian, medical doctor or other clinician. The term "prophylactically effective amount" is intended to mean that amount of a pharmaceutical drug that will prevent or reduce the risk of occurrence of the biological or medical event that is sought to be prevented in a tissue, a system, animal or human by a researcher, veterinarian, medical doctor or other clinician. The dosage regimen utilizing a COX-2 inhibitor in combination with a NK-1 receptor antagonist is selected in accordance with a variety of factors including type, species, age, weight, sex and medical condition of the patient; the severity of the condition to be treated; the route of administration; the renal and hepatic function of the patient; and the particular compound or salt or ester thereof employed. Since two different active agents are being used together in a combination therapy, the potency of each of the agents and the interactive effects achieved by combining them together must also be taken into account. A consideration of these factors is well within the purview of the ordinarily skilled clinician for the purpose of determining the therapeutically effective or prophylactically effective dosage amounts needed to prevent, counter, or arrest the progress of the condition.
The term "patient" includes mammals, especially humans, who take a COX-2 inhibitor in combination with a NK-1 receptor antagonist for any WO 99/59635 PCT/G B99/0 1632 -44of the uses described herein. Administering of the drug combination to the patient includes both self-administration and administration to the patient by another person.
The inhibitor of cyclooxygenase-2 may be administered at a dosage level up to conventional dosage levels for NSAIDs. Suitable dosage levels will depend upon the antiinflammatory effect of the chosen inhibitor of cyclooxygenase-2, but typically suitable levels will be about 0.001 to mg/kg per day, preferably 0.005 to 30mg/kg per day, and especially 0.05 to per day. The compound may be administered on a regimen of up to 6 times per day, preferably 1 to 4 times per day, and especially once per day.
A suitable dosage level for the NK-1 receptor antagonist is about 0.05 to 1500mg per day, preferably about 0.25 to 1500mg per day, and especially about 0.25 to 500mg/kg per day. The compounds may be administered on a regimen of up to 6 times per day, preferably 1 to 4 times per day, especially 1 or 2 times daily.
The active agents employed in the instant combination therapy can be administered in such oral forms as tablets, capsules (each of which includes sustained release or timed release formulations), pills, powders, granules, elixirs, tinctures, suspensions, syrups, and emulsions. The instant invention includes the use of both oral rapid-release and timecontrolled release pharmaceutical formulations. A particular example of an oral time-controlled release pharmaceutical formulation is described in U.S Patent No. 5,366,738. Oral formulations are preferred. Such pharmaceutical compositions are known to those of ordinary skill in the pharmaceutical arts; for example, see Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, PA.
In the methods of the present invention, the active agents are typically administered in admixture with suitable pharmaceutical diluents, excipients or carriers (collectively referred to herein as "carrier" materials) suitably selected with respect to the intended form of WO 99/59635 PCT/G B99/01632 administration, that is, oral tablets, capsules, elixirs, syrups and the like, and consistent with conventional pharmaceutical practices.
For instance, for oral administration in the form of a tablet or capsule, the active drug component can be combined with a non-toxic, pharmaceutically acceptable, inert carrier such as lactose, starch, sucrose, glucose, modified sugars, modified starches, methyl cellulose and its derivatives, dicalcium phosphate, calcium sulfate, mannitol, sorbitol and other reducing and non-reducing sugars, magnesium stearate, steric acid, sodium stearyl fumarate, glyceryl behenate, calcium stearate and the like.
For oral administration in liquid form, the drug components can be combined with non-toxic, pharmaceutically acceptable inert carrier such as ethanol, glycerol, water and the like. Moreover, when desired or necessary, suitable binders, lubricants, disintegrating agents and coloring and flavoring agents can also be incorporated into the mixture.
Stabilizing agents such as antioxidants (BHA, BHT, propyl gallate, sodium ascorbate, citric acid) can also be added to stabilize the dosage forms. Other suitable components include gelatin, sweeteners, natural and synthetic gums such as acacia, tragacanth or alginates, carboxymethylcellulose, polyethylene glycol, waxes and the like.
The active drugs can also be administered in the form of liposome delivery systems, such as small unilamellar vesicles, large unilamellar vesicles and multilamellar vesicles. Liposomes can be formed from a variety of phospholipids, such as cholesterol, stearylamine or phosphatidylcholines.
Active drug may also be delivered by the use of monoclonal antibodies as individual carriers to which the compound molecules are coupled. Active drug may also be coupled with soluble polymers as targetable drug carriers. Such polymers can include polyvinylpyrrolidone, pyran copolymer, polyhydroxy-propyl-methacrylamide-phenol, polyhydroxy-ethyl-aspartamide-phenol, or polyethyleneoxide-polylysine substituted with palmitoyl residues. Furthermore, active drug may be WO 99/59635 PCT/G B99/01632 -46coupled to a class of biodegradable polymers useful in achieving controlled release of a drug, for example, polylactic acid, polyglycolic acid, copolymers of polylactic and polyglycolic acid, polyepsilon caprolactone, polyhydroxy butyric acid, polyorthoesters, polyacetals, polydihydropyrans, polycyanoacrylates and cross linked or amphipathic block copolymers of hydrogels.
Although the active agents of the present method may be administered in divided doses, for example two or three times daily, a single daily dose of each of the COX-2 inhibitor and the NK-1 receptor antagonist is preferred, with a single daily dose of both agents in a single pharmaceutical composition being most preferred.
The instant invention also encompasses a process for preparing a pharmaceutical composition comprising combining the COX-2 inhibitor and the NK-1 receptor antagonist with a pharmaceutically acceptable carrier, as well as the pharmaceutical composition which is made by combining the COX-2 inhibitor and the NK-1 receptor antagonist with a pharmaceutically acceptable carrier.
A therapeutically effective amount of a COX-2 inhibitor and a NK-1 receptor antagonist can be used together for the preparation of a medicament useful for preventing or reducing the risk of developing an inflammatory disorder such as rheumatoid arthritis, halting or slowing the progression of an inflammatory disorder such as rheumatoid arthritis, once it has become clinically manifest, and preventing or reducing the risk of a first or subsequent occurrence of an inflammatory disorder such as rheumatoid arthritis. For example, the medicament may be comprised of a COX-2 inhibitor in combination with about 1 mg to 300 mg of a NK-1 receptor antagonist, or more particularly about 3 mg to 100 mg of the NK-1 receptor antagonist. More specific amounts of NK-1 receptor antagonist which may be used in the medicament preparation include 1 mg, 3 mg, 5 mg, 10 mg, 20 mg, 30 mg, 50 mg, 100 mg and 300 mg, as well as sub-milligram amounts of NK-1 receptor antagonists which have WO 99/59635 PCT/G B99/01632 -47 sufficient potency at such levels. As a further example, the medicament may be comprised of a NK-1 receptor antagonist, for example, at the above dosages, in combination with about 0.1 to 20 mg of a COX-2 inhibitor.
The instant invention also encompasses the use of a NK-1 receptor antagonist for the manufacture of a medicament for the combined use with a cyclooxygenase-2 inhibitor for preventing or reducing the risk of developing an inflammatory disorder, for halting or slowing the progression of an inflammatory disorder, or for preventing or reducing the risk of occurrence or recurrence of an inflammatory disorder; and the use of a cyclooxygenase-2 inhibitor for the preparation of a medicament for the combined use with a NK-1 receptor antagonist for preventing or reducing the risk of developing an inflammatory disorder, for halting or slowing the progression of an inflammatory disorder, or for preventing or reducing the risk of occurrence or recurrence of an inflammatory disorder.
The compounds of formulae (III), (VII), (VIII), (XI) and (XII) may be prepared by the methods described in EP-A-0 577 394 (or WO 95/16679), WO 95/18124, WO 95/23798, WO 97/49710, EP-A-0 436 334, WO 93/21155, EP-A-0 591 040, EP-A-0 532 456, EP-A-0 443 132, WO 92/17449, WO 95/08549 and WO 95/14017, respectively.
Particularly preferred NK-1 receptor antagonists of the formulae (III), (VII), (VIII), (XI) and (XII) for use in the present invention are compounds which are potent NK-1 receptor antagonists, i.e. compounds with an NK-1 receptor affinity (ICso) of less than 100nM. Most preferred are compounds of formulae (III) and
(IV).
Even more preferred NK-1 receptor antagonists of use in the present invention are compounds which are potent NK-1 receptor antagonists with an NK-1 receptor affinity (ICso) of less than favourably less than 2nM and preferably less than InM.
WO 99/59635 PCT/GB99/01632 -48- Especially preferred NK-1 receptor antagonists of use in the present invention are orally active, long acting, CNS-penetrant NK-1 receptor antagonists, identified using a combination of the following assays: ASSAY 1: NK-1 Receptor binding NK-1 receptor binding assays are performed in intact Chinese hamster ovary (CHO) cells expressing the human NK-1 receptor using a modification of the assay conditions described by Cascieri et al, J.
Pharmacol. Exp. Ther., 1992, 42, 458. Typically, the receptor is expressed at a level of 3x10 5 receptors per cell. Cells are grown in monolayer culture, detached from the plate with enzyme-free dissociation solution (Speciality Media Inc.), and washed prior to use in the assay. 125 1-TyrSsubstance P (0.lnM, 2000Ci/mmol; New England Nuclear) is incubated in the presence or absence of test compounds (dissolved in 51 dimethylsulphoxide, DMSO) with 5x10 4 CHO cells. Ligand binding is performed in 0.25ml of 50mM Tris-HC1, pH7.5, containing 5mM MnC1 2 150mM NaC1, 0.02% bovine serum albumin (Sigma), 50ig/ml chymostatin (Peninsula), 0.1nM phenylmethylsulphonyl fluoride, 2ag/ml pepstatin, 2pg/ml leupeptin and 2.8pg/ml furoyl saccharine. The incubation proceeds at room temperature until equilibrium is achieved (>40 minutes) and the receptor-ligand complex is harvested by filtration over GF/C filters presoaked in 0.1% polyethylenimine using a Tomtek 96-well harvester. Nonspecific binding is determined using excess substance P (ilM) and represents <10% of total binding.
ASSAY 2: Gerbil Foot-Tapping CNS-penetrant NK-1 receptor antagonists for use in the present invention can be identified by their ability to inhibit foot tapping in gerbils induced by central infusion of NK-1 receptor agonists such as GR73632, WO 99/59635 PCT/GB99/01632 -49based on the method of Rupniak Williams, Eur. J. Pharmacol., 1994, 265, 179.
Male or female Mongolian gerbils (35-70g) are anaesthetised by inhalation of an isoflurane/oxygen mixture to permit exposure of the jugular vein in order to permit administration of test compounds or vehicle in an injection volume of approximately 5ml/kg i.v. Alternatively, test compounds may be administered orally or by subcutaneous or intraperitoneal routes. A skin incision is then made in the midline of the scalp to expose the skull. The selective NK-1 receptor agonist (e.g.
GR73632 (d Ala[L-Pro 9 ,Me-Leu 1]-substance is infused directly into the cerebral ventricles 3pmol in 5pl depending on test substance) by vertical insertion of a cuffed 27 gauge needle to a depth of below bregma. The scalp incision is closed and the animal allowed to recover from anaesthesia in a clear perspex observation box (approximately 25cm x 20cm x 20cm). The duration and/or intensity of hind foot tapping is then recorded continuously for approximately minutes.
ASSAY 3: Ferret Emesis Individually housed male ferrets (1.0 -2.5 kg) are dosed orally by gavage with test compound. Ten minutes later they are fed with approximately 100g of tinned cat food. At 60 minutes following oral dosing, cisplatin (10mg/kg) is given i.v. via a jugular vein catheter inserted under a brief period of halothane anaesthesia. The catheter is then removed, the jugular vein ligated and the skin incision closed. The ferrets recover rapidly from the anaesthetic and are mobile within 10-20 minutes. The animals are observed continuously during recovery from the anaesthetic and for 4 hours following the cisplatin injection, after which time the animals are killed humanely. The numbers of retches and vomits occurring during the 4 hours after cisplatin administi-ation are recorded by trained observers.
WO 99/59635 PCT/G B99/01632 ASSAY 4: Footpad FCA Guinea Pig Model Male Dunkin Hartly guinea pigs (180g-200g) are housed in groups in a twelve hour dark/light cycle and given vitamin C supplemented food and water ad libitum. Inflammation is induced by injection of 100pl Freunds Complete Adjuvant (FCA) into the right hind footpad. The FCA is composed of 10mg/ml heat killed mycobacterium blended with sterile paraffin. For the purposes of the study 6 animals are included in each treatment group and are dosed with experimental compounds as provided on a daily basis.
Inflammation is assessed as follows: 1. The diameter of the hind footpads is measured with vernier calipers at a consistent mid plantar site.
2. Measurement of thermal hyperalgesia is determined by the Hargreaves Method on unrestrained animals. The method determines the withdrawal latency to an infra-red source (Ugo Basile). Hyperalgesia is assessed 4 hours after dosing.
3. Mechanical hyperalgesia is assessed using the Ugo Basile analgesymeter according to the Randall-Selitto test. Force is applied onto the foot pad at a designated site increasing at 4.8g per second.
Hyperalgesia is assessed 4 hours after dosing.
A suitable selection cascade for NKI antagonists of use according to the present invention is as follows: Determine affinity for human NK 1 receptor in radioligand binding studies (Assay select compounds with IC 5 o 10nM, preferably ICso 2nM, especially IC 5 o InM.
WO 99/59635 PCT/GB99/01632 -51- (ii) Determine ability of compounds to penetrate CNS by their ability to inhibit foot tapping in gerbils induced by central injection of an NKi agonist (Assay select compounds that inhibit foot tapping with
ID
50 3mg/kg and preferably ID 50 1mg/kg i.v. when administered immediately prior to central NKI agonist challenge, or ID 50 3 0mg/kg p.o., and preferably ID 5 o 10mg/kg p.o. 1 hour prior to challenge.
(iii) Determine central duration of action of compounds in gerbil foot tapping assay following intravenous administration 24 hours prior to central NK 1 agonist challenge; select compounds showing 25-fold loss of potency compared with ID 5 o determined in step (ii) above with the proviso that ID 0 o 10mg/kg and preferably 5mg/kg i.v. after 24 hour pre-treatment.
(iv) Determine oral bioavailability of compounds by pharmacokinetic analysis, activity in gerbil foot tapping assay following oral administration and/or by ability to inhibit cisplatin-induced emesis in ferrets (Assay select compounds with ID 90 3mg/kg and preferably
ID
9 0 I1mg/kg p.o.
Particularly preferred compounds of use in the present invention are identified using steps to (iv) followed by step Determine activity of compounds in assays for inhibition of pharmacologically evoked foot tapping in gerbils and/or inhibition of adjuvant arthritis in guinea-pigs (Assay Select compounds with ID 50 and preferably IDso Yet further preferred compounds of use in the present invention may be selected from those compounds which satisfy the NK-1 receptor binding criteria of step which, in addition, have 5-fold shift in affinity when incubated in the presence of human serum albumin (HSA) to show non-specific protein binding.
One example of a NK-1 receptor antagonist of use in the present invention is the compound 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)- WO 99/59635 PCT/GB99/01632 -52 ethoxy)-3-(S)-(4-fluorophenyl)-4-(3-(5-oxo- H,4H-1,2,4-triazolo)methyl)morpholine, the preparation of which is described in International Patent Specification No. WO 95/16679. In the aforementioned assays, this compound has the following activity: human NK-1 receptor binding: ICso=0.1nM gerbil foot-tapping (5 mins.): ID50=0.36mg/kg i.v.
gerbil foot-tapping (24 hrs.): IDso=0.33mg/kg i.v.
ferret emesis: ID9o<3mg/kg p.o.
Another example of a NK-1 receptor antagonist of use in the present invention is the compound bis(trifluoromethyl)phenyl)ethoxy)-4-(5-(N,N-dimethylamino)methyl-1,2,3triazol-4-yl)methyl-3-(S)-phenylmorpholine, the preparation of which is described in International Patent Specification No. WO 95/18124. In the aforementioned assays, this compound has the following activity: human NK-1 receptor binding: IC 5 o=0.25nM gerbil foot-tapping (5 mins.): IDso=0.12mg/kg i.v.
gerbil foot-tapping (24 hrs.): IDso=0.17mg/kg i.v.
Especially preferred COX-2 inhibitors of use in the present invention are identified using the following one or more of the following selection criteria: Determine the affinity for human COX-2 in whole cell assay; select compounds with ID5 0 <40nM, and preferably ID 50 (ii) Determine oral bioavailability of compounds by pharmacokinetic analysis or inhibition of carrageenan-induced paw oedema in rats following oral administration. Select compounds with and preferably ED5o<2.5mg/kg p.o.
WO 99/59635 PCT/G B99/01632 -53- (iii) Determine the ability of compounds to induce gastric ulceration or increase in faecal 51 Cr excretion. Select compounds that have no adverse gastrointestinal effects at >100mg/kg when administered up to two times a day.
(iv) Determine antinociceptive effects of compounds in carrageenan-induced hyperalgesia in rats; select compounds with and preferably EDso52.5mg/kg p.o.
Determine the affinity for COX-2 in human whole blood assay which is used as an index for biochemical efficacy in the clinic and select compounds with ICsoIIpM for inhibition of PGE 2 The following examples illustrate pharmaceutical compositions according to the invention.
These formulations may be prepared with separate active ingredients or with a combination of active ingredients in one composition.
In such combined preparations, the ratio of the COX-2 inhibitor and the NK-1 receptor antagonist will depend upon the choice of active ingredients.
EXAMPLE 1 Amount (mg) per tablet NK-1 receptor antagonist 50.0 100.0 300.0 Microcrystalline cellulose 80.0 80.0 80.0 Modified food corn starch 80.0 80.0 80.0 Lactose 189.5 139.5 139.5 Magnesium Stearate 0.5 0.5 The active ingredient, cellulose, lactose and a portion of the corn starch are mixed and granulated with 10% corn starch paste. The resulting granulation is sieved, dried and blended with the remainder of the corn starch and the magnesium stearate. The resulting granulation is WO 99/59635 PCT/GB99/01632 -54then compressed into tablets containing 50mg, 100mg and 3 0 0 mg of the NK-1 receptor antagonist per tablet.
NK-1 receptor antagonist COX-2 inhibitor Microcrystalline cellulose Modified food corn starch Lactose Magnesium Stearate EXAMPLE 2 Amount (mg) per tablet 50.0 100.0 300.0 20.0 20.0 20.0 80.0 80.0 80.0 80.0 80.0 80.0 169.5 119.5 119.5 0.5 0.5 The active ingredients, cellulose, lactose and a portion of the corn starch are mixed and granulated with 10% corn starch paste. The resulting granulation is sieved, dried and blended with the remainder of the corn starch and the magnesium stearate. The resulting granulation is then compressed into tablets containing 20mg of the COX-2 inhibitor and 100mg and 300mg of the NK-1 receptor antagonist per tablet.
EXAMPLE 3 Wet granulated tablet composition COX-2 Inhibitor Microcrystalline cellulose Lactose monohydrate Hydroxypropyl cellulose Croscarmellose sodium Iron oxide Magnesium stearate 2 79 79 0 Amount (mg) !5 12.5 .7 86 .7 86 6 6 8 8 .6 0.6 per tablet 10 87.2 87.2 6 8 0.6 1 89.7 89.7 6 8 0.6 1 WO 99/59635 PCT/GB99/01632 Tablet dose strengths of between 5 and 25 mg can be accomodated by varying total tablet weight, and the ratio of the first three ingredients.
Generally it is preferable to maintain a 1:1 ratio for microcrystalline cellulose:lactose monohydrate.
EXAMPLE 4 Directly compressed tablet composition Amount (mg) per tablet COX-2 Inhibitor 25 12.5 10 Microcrystalline cellulose 106.9 113.2 42.5 Lactose anhydrate 106.9 113.2 42.5 Crosmellose sodium 7.5 7.5 4 4 Magnesium stearate 3.7 3.7 1 1 Tablet dose strengths of between 5 and 25 mg can be accomodated by varying total tablet weight, and the ratio of the first three ingredients.
Generally it is preferable to maintain a 1:1 ratio for microcrystalline cellulose:lactose monohydrate.
EXAMPLE Hard gelatin capsule composition Amount (mg) per capsule COX-2 Inhibitor Microcrystalline cellulose 37 Lactose anhydrate 37 Magnesium stearate 1 Hard gelatin capsule 1 capsule Capsule dose strengths of between 1 and 50 mg can be accomodated by varying total fill weight, and the ratio of the first three ingredients.
WO 99/59635 PCT/GB99/01632 -56- Generally it is preferable to maintain a 1:1 ratio for microcrystalline cellulose lactose monohydrate.
EXAMPLE 6 Oral solution Amount per 5 ml dose COX-2 Inhibitor 50 mg Polyethylene oxide 400 to 5 ml Solution dose strengths of between 1 and 50 mg/5ml can be accomodated by varying the ratio of the two ingredients.
EXAMPLE 7 Oral suspension Amount per 5 ml dose COX-2 Inhibitor 100 mg Polyvinylpyrrolidone 150 mg Polyoxyethylene sorbitan monolaurate 2.5 mg Benzoic acid 10 mg sorbitol solution to 5 ml Suspension dose strengths of between 1 and 50 mg/5ml can be accomodated by varying the ratio of the first two ingredients.
EXAMPLE 8 Intravenous infusion Amount per 200ml dose COX-2 inhibitor 1 mg Polyethylene oxide 400 0.2 mg Sodium chloride 1.8 mg Purified water to 2 00ml WO 99/59635 PCT/GB99/0 1632 -57- While the invention has been described and illustrated with reference to certain particular embodiments thereof, those skilled in the art will appreciate that various changes, modifications and substitutions can be made therein without departing from the spirit and scope of the invention. For example, effective dosages other than the particular dosages as set forth herein above may be applicable as a consequence of variations in the responsiveness of the mammal being treated for any of the indications for the active agents used in the instant invention as indicated above. Likewise, the specific pharmacological responses observed may vary according to and depending upon the particular active compound selected or whether there are present pharmaceutical carriers, as well as the type of formulation and mode of administration employed, and such expected variations or differences in the results are contemplated in accordance with the objects and practices of the present invention. It is intended, therefore, that the invention be defined by the scope of the claims which follow and that such claims be interpreted as broadly as is reasonable.

Claims (8)

1. Use of a selective COX-2 inhibitor and a NK-1 receptor antagonist for the manufacture of a medicament for the treatment or prevention of an inflammatory disorder, wherein said selective COX-2 inhibitor is selected from the group consisting of:
3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone; 3 4 -difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(SH)-furanone; 5,5-dimethyl-4-(4-(methylsulfonyl)pheny1)-3-(3-fluorophenyl)-5H-.firan2- 10 one; ,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)..sHuran-2one;
5-chloro-3-( 4 -(methylsulfonyl)phenyl)-2-(2-methyl.s.pyridinyl)pyidine; 2 3 ,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten.. -one; S(S)-5-ethyl- 5 -methyl-4-(4-(methylsulfonyl)phenyl)3-(2-propoxy)-5.H. furan-2-one; 5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)3.(3,4.difluorophenyl).SH furan-2-one; 3 2 -thiazolyl)methoxy)-4-(4-(methylsulfonyl)phenyl).s,s.dimethyl.5H- furan-2-one; .20 3 -propyloxy- 4 -(4-(methylsulfonyl)phenyl)-,..dimethylsHfuran2-one; l-cyclopropylethoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl).5H- furan-2-one; 3 -(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl).SH. dirfuran-2-o 3 -(cyopropyoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)..2,s..dofuan 2-ol; -59- 5,5-dimethy1-3-(3-fluoropheny)-2-hydroxy-4-(4-(methysufony)pheny). 5-chloro-3-(4-(methylsulfonyl)phenyl)-2-(3-pyridinyl)pyridine; 4 -(5-methyl- 3 -phenyl-4-isoxazolyl)benzenesulfonamide; 5-(4-fluorophenyl)-1- [4-(methylsulfonyl)phenyl] -3- (trifluoromethyl)pyrazole; 4-(4-fluorophenyl)-5- [4-(methylsulfonyl)phenyl] -1-phenyl-3- (trifluoromethyl)pyrazole; 4 4 -chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-1- yl)benzenesulfonamiide; 4-(3,5-bis(4-methylphenyl)- 1H-pyrazol-1-yl)benzenesulfonamide; 9999 4 4 -chlorophenyl)-3-phenyl-1H-pyrazol-1-yl)benzenesulfonamide; 4-39bs4mthxpey)l*yrzl1y**zeeufnnie 4 4 -chlorophenyl)-3-(4-methylphenyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4 4 -chlorophenyl)-3-(4-nitrophenyl)-lH-pyrazol-l- yl)benzenesulfonamide; 4 4 -chlorophenyl)-3-(5-chloro-2-thienyl)-lH-pyrazol-l-.. yl)benzenesulfonamide;, 4 -(4-chloro-3,5-diphenyl- 1H-pyrazol-1-yl)benzenesulfonamide; 4 4 -chloropheny1)-3-(trifluoromethy)-lH-pyrazol-l- yl)benzenesulfonamide; 4 -(5-phenyl)-3-(trifluoromethyl)-1H-pyrazol-1..yl)benzenesulfonamide; 4 4 -fluorophenyl)-3-(trifluoromethyl)- 1H-pyrazol- 1- yl)benzenesulfonamide; 4 4 -methoxyphenyl)-3-(trifluoromethyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-(difluoromethyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4 4 -methylphenyl)-3-(trifluoromethyl)-lH-pyrazol-l yl)benzenesulfonamide; 60 4 -(4-chloro-5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1- ylbenzenesulfonamide; 4 -(3-(difluoromethyl)-5-(4-methylphenyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(3-(difluoromethyl)-5-phenyl-1H-pyrazol-1-yl)benzenesulfonamide; 4-(3-(difluoromethyl)-5-(4-methoxyphenyl)-1H-pyrazol-l- yl)benzenesulfonamide; 4 -(3-cyano-5-(4-fluorophenyl)-1H-pyrazol-1-yl)benzenesulfonamide; 4 -(3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4 -(5-(3-fluoro-4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-l- S...yl)benzenesulfonamide; SS 4 4 -chloro-5-phenyl-1H-pyrazol-1-yl)benzenesulfonainide; 4 -(5-(4-chlorophenyl)-3-(hydroxyphenyl)-1H-pyrazol-l- yl)benzenesulfonamide; 4 4 -(N,N-dimethylamino)phenyl)-3-(trifluoromethyl)-1H-pyrazol- 1- yl)benzenesulfonamide; **Sa 5-( 4 -fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro 4-(6-(4-fluorophenyl)spiro [2.4]hept-5-en-5-yl)benzenesulfonainide; 6 4 -fluorophenyl)-7-(4-(methylsulfonyl)phenyl)spiro [3 .4]oct-6-ene; a 0 3 -chloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.4]hept- 1.a. 4 -(6-(3-chloro-4-methoxyphenyl)spiro yl)benzenesulfonamide; 5-(3,5-dichloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)- spiro [2.4lhept-5-ene; 3 -chloro-4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro ene; 4-(6-(3,4-dichlorophenyl)spiro 2 -(3-chloro-4-fluorophenyl)-4-(4-fluorophenyl)-5-(4- methylsulfonylphenyl)thiazole; 61 2-(2-chlorophenyl)-4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)thiazole; 5-(4-fluorophenyl)-4-(4-methylsulfonylphenyl)-2-methylthiazole; 4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-2-(2-thienyl)thiazole; 4-(4-fluorophenyl)-5-(4-methylsulfonylpheny1)-2-benzylaminothiazole; 4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-2-( 1-propylamino)thiazole; 2-((3,5-dichlorophenoxy)methyl)-4-(4-fluorophenyl)-5-(4- (methylsulfonyl)phenyl)thiazole; 5-(4-fluorophenyl)-4-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 1-methylsulfonyl-4-(1 ,1-dimethyl-4-(4-fluorophenyl)cyclopenta-2,4-dien-3- yl)benzene; 4-(4-(4-fluorophenyl)-1 ,1-dimethylcyclopenta-2,4-dien-3- yl)benzenesulfonamide; 0 5-(4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro hepta-4,6-diene; 4-(6-(4-fluorophenyl)spiro [2.4lhepta-4,6-dien-5-yl)benzenesulfonamide;
6-(4-fluorophenyl)-2-methoxy-5-(4-(methylsulfonyl)phenyl)-pyridine-3- carbonitrile; 2-bromo-6-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-pyridine-3- carbonitrile; 6-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-phenyl-pyridine-3- carbonitrile; 4-(2-(4-methylpyridin-2-yl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; 4-(2-(5-methylpyridin-3-yl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; 4-(2-(2-methylpyridin-3-yl)-4-(trifluoromethyl)- 1H-imidazol- 1- yl)benzenesulfonamide; 1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H-imidazol-2- yl)benzenesulfonamide; 1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)- 1H-imidazol-2- yl)pyridine; 62 2 -methyl-4-(1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-lH-imidazol- 2-yl)pyridine; 2 -methyl-6-(1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H-imidazol- 2-yl)pyridine; 4 -(2-(6-methylpyridin-3-yl)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonamide; 2 4 -difluorophenyl)-l-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-lH- imidazole; 4-(2-(4-methylphenyl)-4-(trifluoromethyl)-lH-imidazol-l- yl)benzenesulfonamide; 2 4 -chlorophenyl)-1-(4-(methylsulfonyl)phenyl)-4-methyl-lH-iniidazole; 2 4 -chlorophenyl)-1-(4-(methylsulfonyl)phenyl)-4-phenyl-1H-imidazole; 2-(4-chlorophenyl)-4-(4-fluorophenyl)- 1-(4-(methylsulfonyl)phenyl)-1H- imidazole; 2-(3-fluoro-4-methoxyphenyl)- 1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)-1H-imidazole; l-(4-(methylsulfonyl)phenyl)-2-phenyl-4-trifluoromethyl-lH-imidazole; 2 4 -methylphenyl)-1-(4-(methylsulfonyl)phenyl)-4-trifluoromethyl- 1H- imidazole; 20 4 -(2-(3-chloro-4-methylphenyl)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonamide; 2-(3-fluoro-5-methylphenyl)-1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)-1H-imidazole; 4 2 -(3-fluoro-5-methylphenyl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; 2 3 -methylphenyl)-1-(4-(methylsulfonyl)phenyl).4-(trifluoromethyl)-lH- imidazole; 4-(2-(3-methylphenyl)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonamide; l-( 4 -(methylsulfonyl)phenyl)-2-(3-chlorophenyl)-4-(trifluoromethyl)-lH- ~Tr~.\i~dazole; 63 4-(2-(3-chlorophenyl)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonamide; 4 -(2-phenyl-4-(trifluoromethyl)-1H-imidazol-1-yl)benzenesulfonamide; 4 2 -(4-methoxy-3-chlorophenyl)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonamide; l-allyl- 4 -(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl). 1H-pyrazole; 4 -(1-ethyl-4-(4-fluorophenyl)-5-(trifluoromethyl)- 1H-pyrazol-3- yl)benzenesulfonamide; N-phenyl-(4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5- (trifluoromethyl)-1H-pyrazol-1-yl)acetainide; ethyl 4 -(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl)- 1H-pyrazol-1-yl)acetate; 4 -(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)- 1-(2-phenylethyl)-1H- pyrazole; 4 -(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)- 1-(2-phenylethyl)-5- (trifluoromethyl)pyrazole; l-ethyl- 4 -(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl).5.(trifluoromethyl)- 1H-pyrazole; 20 5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(trifluoromethyl)-1H- imidazole; 0. 4-(4-(methylsulfonyl)phenyl)-5-(2-thiophenyl)-2-(trifluoromethyl)-lH- 0. 0.:imidazole; 4 -fluorophenyl)-2-methoxy-4-(4-(methylsulfonyl)phenyl)-6- (trifluoromethyl)pyridine; 2 -ethoxy-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-6. (trifluoromethyl)pyridine; 4 -fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(2-propynyloxy)-6- (trifluoromethyl)pyridine; 2-bromo-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)6. (trifluoromethylpyridine; -64- 4-(2-(3-chloro-4-methoxyphenyl)-4,5-difluorophenyl)benzenesulfonanide; 1-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)benzene; 5-difluoromethyl-4-(4-(methylsulfonyl)phenyl)-3-phenylisoxazole; 4-(3-ethyl-5-phenylisoxazol-4-yl)benzenesulfonamide; 4-(5-difluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 4-(5-hydroxymethyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 1-(2-(4-fluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-fluoro-2-methylphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-chlorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(2,4-dichlorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-trifluoromethylphdnyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-methylthiophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-fluorophenyl)-4,4-dimethylcyclopenten- 1-yl)-4- (methylsulfonyl)benzene; 4 -(2-(4-fluorophenyl)-4,4-dimethylcyclopenten-1-yl)benzenesulfonamide; 1-(2-(4-chlorophenyl)-4,4-dimethylcyclopenten- l-yl)-4- (methylsulfonyl)benzene; 4-2(-hoohny)44dmtycylpne-*lbeznsloaie 4 -(2-(4-lorophenyl)-44dtycyclopenten-1-yl)benzenesulfona inide; 4 -(2-(4-lorophenyl)cyclopenten-1-yl)benzenesulfonamide; 4 -(2-(4-loromexphenyl)cyclopenten-1-yl)benzenesulfonamide; 1-(2-(3-ho4-methoxyphenyl)cyclopenten- 1-yl)-4-ylufnLbzn; l- 2 (,-iloohnlccoetn1y)4(methylsulfonyl)benzene; 4 -(2-(3-loro-4-metophenyl)cyclopenten-1-yl)benzenesulfonamide; 4 -(2-(2-methylpyridin-5-yl)cyclopenten-1-yl)benzenesulfonamide; ethyl 2-(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)-2- benzyl-acetate; 2 -(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)acetic acid; 65 2-(tert-butyl)-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazole; 4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-phenyloxazole; 4-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)oxazole; and 4-(5-(3-fluoro-4-methoxyphenyl)-2-trifluoromethyl-4- oxazolyl)benzenesulfonamide; or a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition for the treatment or prevention of an inflammatory disorder comprising a selective COX-2 inhibitor and a NK-1 receptor antagonist, together with at least one ::.pharmaceutically acceptable carrier or excipient, wherein said selective COX-2 inhibitor is selected from the group consisting of: 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone; 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone; 5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3-(3-fluorophenyl)-5H-furan-2- one; 5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one; 5-chloro-3-(4-(methylsulfonyl)phenyl)-2-(2-methyl-5-pyridinyl)pyridine; 2 3 ,5-difiuorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten- 1-one; 20 5(S)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H- furan-2-one; S-ethyl-S -methyl-4-(4-(methylsulfonyl)phenyl)-3-(3,4-difluorophenyl)-5H- furan-2-one; 3 2 -thiazolyl)methoxy)-4-(4-(methylsulfonyl)phenyl)-5,5-.dimethyl-5H- furan-2-one; 3 -propyloxy-4-(4-(methylsulfonyl)phenyl)-5,5-dimethyl-5H-furan-2-one; l-cyclopropylethoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl)-5H- furan-2-one; sodium 2 -(4-chlorophenyl)-3-(4-(methylsulfonyl)phenyl)-4-oxo-2- pentenoate; 66 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H- furan-2-one; 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-2,5- dihydrofuran-2-ol; 3-isopropoxy-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-2,5-dihydrofuran- 2-ol; 5,5-dimethyl-3-(3-fluorophenyl)-2-hydroxy-4-(4-(methylsulfonyl)phenyl)- 5-chloro-3-(4-(methylsulfonyl)phenyl)-2-(3-pyridinylpyridine; 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; 5-(4-fluorophenyl)-1- [4-(methylsulfonyl)phenyl] -3- :5 (trifluoromethyl)pyrazole; 4-(4-fluorophenyl)-5- [4-(methylsulfonyl)phenyl] -1-phenyl-3- ~.(trifluoromethyl)pyrazole; 4-(5-(4-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(3,5-bis(4-methylphenyl)-1H-pyrazol-1-yl)benzenesulfonamide 4-(5-(4-chlorophenyl)-3-phenyl-1H-pyrazol-1-yl)benizenesulfonamide; 4-(3,5-bis(4-methoxyphenyl)- 1H-pyrazol-1-yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(4-methylphenyl)-1H-pyrazol-1- yl)benzenesulfonamide; :4-(5-(4-chlorophenyl)-3-(4-nitrophenyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(5-chloro-2-thienyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(4-chloro-3,5-diphenyl-1H-pyrazol-1-yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(5-phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide; 4-(5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1- yl)benzenesulfonamide; 67 4 -(5-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-l- yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(difluoromethyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-l- yl)benzeniesulfonainide; 4 -(4-chloro-5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(3-(difluoromethyl)-5-(4-methylphenyl)-1H-pyrazol-1- yl)benzenesulfonamide; :2 4 -(3-(difluoromethyl)-5-phenyl-1H-pyrazol-1-yl)benzenesulfonamide; 4 -(3-(difluoromethyl)-5-(4-methoxyphenyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(3-cyano-5-(4-fluorophenyl)- 1H-pyrazol-1-yl)benzenesulfonamide; 4 3 -(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4 -(5-(3-fluoro-4-methoxyphenyl)-3-(trifluoromethyl)-lH-pyrazol-1- yl)benzenesulfonamide; 4 4 -chloro-5-phenyl-lH-pyrazol-1-yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-(hydroxyphenyl)-lH-pyrazol-1- yl)benzenesulfonamide; 4 4 -(N,N-dimethylamino)phenyl)-3-(trifluoromethyl)-lH-pyrazol-1- yl)benzenesulfonamide; 4 -fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.4lhept-5-ene; 4 -(6-(4-fluorophenyl)spiro 6-(4-fluorophenyl)-7-(4-(methylsulfonyl)phenyl)spiro oct-6-ene; 3 -chloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)spiro hept- 4 -(6-(3-chloro-4-methoxyphenyl)spiro [2.4lhept-5-en-5- yl)benzenesulfonamide; 68 5-(3,5-dichloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)- Spiro 5-(3-chloro-4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.41 ene; 4-(6-(3,4-dichlorophenyl)spiro 2 -(3-chloro-4-fluorophenyl)-4-(4-fluorophenyl)-5-(4- methylsulfonylphenylthiazole; 2 2 -chlorophenyl)-4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)thiazole; 5-(4-fluorophenyl)-4-(4-methylsulfonylphenyl)-2-methylthiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 4 -(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-2-(2-thienyl)thiazole; 4-4furpey) -4mtyslonlhnl..ezyaiohaoe 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-benzroylaminothiazole; 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-(1-plurolmtnolthiazole; -(-dchloropenoxy-1,-dmethyl-4-(4-fluorophenyl)cyloena(4-den3 (mehylsulfonlmphey;haoe 5-( 4 -fluorophenyl)--(4-methylsulfonylphenyl)2-tiforom4]epthylthize; 1-mehlufny--1 -dmty--(4-fluorophenyl)spyclopenta-2,44,-dien-3-lbneesloaie 4-(4o-(4-fluorophenyl 1 -dimehylylloen-24-deny-3- idne ylbeniteeufnai 6 4 -fluoropheny1)2-hy-5-(4-(methyunyfohnyl)pheny-pyridine-3- carbonitrile; 4 2 -(4-methylpyridin-2-yl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; 69 4-(2-(5-methylpyridin-3-yl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; 4-(2-(2-methylpyridin-3-yl)-4-(trifluoromethyl)-1H-inidazol-1- yl)benzenesulfonamide; 3-(1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H-imidazol-2- yl)benzenesulfonamide; 2-(l-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-lH-imidazol-2- yl)pyridine; 2 -methyl-4-(l-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H-imidazol- 2-yl)pyridine; 2 -methyl-6-(1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H-imidazol- 2-yl)pyridine; 4-(2-(6-methylpyridin-3-yl)-4-(trifluoromethyl)-1H-iniidazol-1- yl)benzenesulfonamide; 2-(3,4-difluorophenyl)- 1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H- imidazole; 4 -(2-(4-methylphenyl)-4-(trifluoromethyl)-1H-imidazol-1- **yl)benzenesulfonamide; 2 -(-hoohnl.-4(ehlufnlpey)4mty-Hiiaoe 2 -(4-chlorophenyl)-1-(4-(methylsulfonyl)phenyl)-4-metyl-1H-imidazole; 2 4 -chlorophenyl)-4-(4-fluorophenyl)-1-(4-(methylsulfonyl)phenyl)- 1H- iridazole; 2 -(3-fluoro-4-methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)-lH-imidazole; l-(4-(methylsulfonyl)phenyl)-2-phenyl-4-trifluoromethyl-lH-imidazole; 2 -(4-methylphenyl)-l-(4-(methylsulfonyl)phenyl)-4-trifluoromethyl-lH- imidazole; 4 -(2-(3-chloro-4-methylphenyl)-4-(trifluoromethyl)-lH-imidazol- 1- yl)benzenesulfonamide; 2-(3-fluoro-5-methylphenyl)- 1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)-1H-imidazole; 70 4 2 -(3-fluoro-5-methylphenyl)-4-(trifluoromethyl)-lH-imidazol-1- yl)benzenesulfonamide; 2 -(3-methylphenyl)-1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl) 1H- imidazole; 4 -(2-(3-methylphenyl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; l-( 4 -(methylsulfonyl)phenyl)-2-(3-chlorophenyl)-4-(trifluoromethyl)-lH- imidazole; 4 -(2-(3-chlorophenyl)-4-(trifluoromethyl)-1H-imidazol-l- yl)benzenesulfonamide; 4 2 -phenyl-4-(trifluoromethyl)-1H-im-idazol-1-yl)benzenesulfonamide; 4 -(2-(4-methoxy-3-chlorophenyl)-4-(trifluoromethyl)- 1H-imidazol-1- 9: yl)benzenesulfonamide; l-allyl- 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl). 1H-pyrazole; 4 -(l-ethyl-4-(4-fluorophenyl)-5-(trifluoromethyl)-1H-pyrazol-3- yl)benzenesulfonamide; :9 *.N-phenyl-(4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-
9. (trifluoromethyl)-1H-pyrazol-1-yl)acetamide; 20 ethyl 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl)- 1H-pyrazol-1-yl)acetate; 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-l-(2-phenylethyl)- 1H- pyrazole; 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-1-(2-phenylethyl)-5- (trifluoromethyl)pyrazole; l-ethyl- 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-s..(trifluoromethyl). lil-pyrazole; 4 -fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(trifluoromethyi)- H- imidazole; 4 4 -(methylsulfonyl)phenyl)-5-(2-thiophenyl)-2-(trifluoromethyl)1lH- imidazole; 71 5-(4-fluorophenyl)-2-methoxy-4-(4-(methylsulfonyl)phenyl)-6- (trifluoromethyl)pyridine; 2 -ethoxy-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-6- (trifluoromethyl)pyridine; 5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(2-propynyloxy)-6- (trifluoromethyl)pyridine; 2-bromo-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-6- (trifluoromethyl)pyridine; 4 2 -(3-chloro-4-methoxyphenyl)-4,5-difluorophenyl)benzenesulfonamide; l-( 4 -fluorophenyl)-2-(4-(methylsulfonyl)phenyl)benzene; 5-difluoromethyl-4-(4-(methylsulfonyl)phenyl)-3-phenylisoxazole; 4-3ehl5phnlsxz.*-lbneesloaie 4 -(5-diloethyl-3-phenylisoxazol-4-yl)benzenesulfonamide; S..oxmty--peyioxzl4y~bneeuloaie 4 -(5-dfrmethyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 1 4 2-(-ydro-2ymethylphenylisyoazol--yl)nzene lamide; nen 4 -(5-ehl-3phenylisycoazo--yl)enzeneulsfnlfonamide 1l-( 2 -(24-dluorophenyl)cyclopenten- 1-yl)-4-(methylsulfonyl)benzene; l-( 2 4 -trfluoro2methylphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; l-( 2 4 -mehlophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; l-( 2 -(4-diorophenyl)c4dmelyclopenten-1-yl)-4-hlufnlbnn; 0 l- 2 (-riloomtypenlcclpne-1y)4(methylsulfonyl)benzene; l-( 2 4 -methlhophenyl)4dmycyclopenten-1-yl)eylesulfonmnee; 2 4 -lorophenyl)-4,4-dimethylcyclopenten-1-yl)-4- (methylsulfonyl)benzene; 4 2 -(4-lorophenyl)-4,4-dimethylcyclopenten- 1-yl)benzenesulfonainde; 4 2 -(4-lorophenyl)-44dtycyclopenten- 1-yl)benzenesulfonamide; 4 2 -(4-lorophenyl)cyclopenten- 1-yl)benzenesulfonamide; -(2-(4-cehoophenyl)cyclopenten- 1-yl)enzeesulfonide zn l-(2-(4,-ethoyphenyl)cyclopenten- 1-yl)-4-(methylsulfonyl)benzene; 72 4-(2-(3-fluoro-4-methoxyphenyl)cyclopenten- -1-yl)benzenesulfonamide; 1-(2-(3-chloro-4-methoxyphenyl)cyclopenten-1-yl)-4- (methylsulfonyl)benzene; 4-(2-(3-chloro-4-fluorophenyl)cyclopenten- 1-yl)benzenesulfonamide; 4-(2-(2-methylpyridin-5-yl)cyclopenten-1-yl)benzenesulfonaniide; ethyl 2-(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)-2- benzyl-acetate; 2-(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)acetic acid; 2-(tert-butyl)-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazole; 4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-phenyloxazole; 4-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)oxazole; and 4 4-(5-(3-fluoro-4-methoxyphenyl)-2-trifluoromethyl-4- oxazolyl)benzenesulfonamide; or a pharmaceutically acceptable salt thereof. 3. A product comprising a selective COX-2 inhibitor and a NK-1 receptor antagonist as a combined preparation for simultaneous, separate or sequential use in the treatment or prevention of an inflammatory disorder, wherein said selective COX-2 inhibitor is selected from the group consisting of: 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone; 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone; 5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3-(3-fluorophenyl)-5H-furan-2- one; 5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one; 5-chloro-3-(4-(methylsulfonyl)phenyl)-2-(2-methyl-5-pyridinyl)pyridine; 2 -(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten- 1-one; 5(S)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H- furan-2-one; 73 5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(3,4-difluorophenyl)-5H- furan-2-one; 3-((2-thiazolyl)methoxy)-4-(4-(methylsulfonyl)phenyl)-5,5-dimethy1-5H- furan-2-one; 3-propyloxy-4-(4-(methylsulfonyl)phenyl)-5,5-dimethyl-5H-furan-2-one; 1-cyclopropylethoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl)-5H- furan-2-one; sodium 2-(4-chlorophenyl)-3-(4-(methylsulfonyl)phenyl)-4-oxo-2- pentenoate; 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H- furan-2-one; 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-2,5- dihydrofuiran-2-ol; ****3-isopropoxy-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-2,5-dihydrofuran- 2-ol; ,5-dimethyl-3-(3-fluorophenyl)-2-hydroxy-4-(4-(methylsulfonyl)phenyl)- 5-chloro-3-(4-(methylsulfonyl)phenyl)-2-(3-pyridinyl)pyridine; ::*4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; 20 5-(4-fluorophenyl)-1- [4-(methylsulfonyl)phenyl] -3- (trifluoromethyl)pyrazole; 4-(5-(4-chlorophenyl)-3-(4-methoxyphenyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4-(3,5-bis(4-methylphenyl)-lH-pyrazol-1-yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-phenyl-1H-pyrazol- 1-yl)benzenesulfonamide; 4-(3,5-bis(4-methoxyphenyl)- li-pyrazol- 1-yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-(4-methylphenyl)-1H-pyrazol-1- yl)benzenesulfonamide;
74- 4-(5-(4-chlorophenyl)-3-(4-nitrophenyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(5-chloro-2-thienyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4 -(4-chloro-3,5-diphenyl-1H-pyrazol-1-yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(5-phenyl)-3-(trifluoromethyl)-1H-pyrazol- 1-yl)benzenesulfonamide; 4-(5-(4-fluorophenyl)-3-(trifluoromethyl)- 1H-pyrazol-1- yl)benzenesulfonamide; e 4-(5-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol- 1- yl)benzenesulfonamide; g~e. 4-(5-(4-chlorophenyl)-3-(difluoromethyl)-1H-pyrazol-1- ylbenzenesulfonamide; 4-(5-(4-methylphenyl)-3-(trifluoromethyl)- 1H-pyrazol-1- yl)benzenesulfonaniide; 4-(4-chloro-5-(4-chlorophenyl)-3-(trifluoromethyl)- 1H-pyrazol-1- ee*yl)benzenesulfonamide; *see4-(3-(difluoromethyl)-5-(4-methylphenyl)-1H-pyrazol- 1- Goo**: 20 yl)benzenesulfonamide; 4-(3-(difluoromethyl)-5-phenyl- 1H-pyrazol-1-yl)benzenesulfonaniide; S. C 4 -(3-(difluoromethyl)-5-(4-methoxyphenyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4 -(5-3-dfurmty)fluorolur-4-methoxypheny)3(rfuomtyl)- 1H-pyrazol- 1- yl)benzenesulfonamide; 4-(4-chloro-5-phenyl- 1H-pyrazol-.1-yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(hydroxyphenyl)- 1H-pyrazol-1- Syl)benzenesulfonamide; 75 4-(5-(4-(N,N-dimethylamino)phenyl)-3-(trifluoromethyl)-1H-pyrazol- 1- yl)benzenesulfonamide; 5-(4-fluorophenyl)-6-(4-(methylsulfonyl)phenylbspiro [2.4lhept-5-ene; 4-(6-(4-fluorophenyl)spiro 6-(4-fluorophenyl)-7-(4-(methylsulfonyl)phenyl)spiro oct-6-ene; 5-(3-chloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenylspiro [2.4lhept- 4-(6-(3-chloro-4-methoxyphenyl)spiro yl)benzenesulfonamide; 5-(3 ,5-dichloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)- Spiro [2.4]hept-5-ene; 5-(3-chloro-4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2 ene; **4-(6-(3,4-dichlorophenyl)spiro [2.4]hept-5-en-5-yl)benzenesulfonamide; 2-(3-chloro-4-fluorophenyl)-4-(4-fluorophenyl)-5-(4- methylsulfonylphenyl)thiazole; 2-(2-chlorophenyl)-4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)thiazole; 5-(4-fluorophenyl)-4-(4-methylsulfonylphenyl)-2-methylthiazole; 4-4furpey)*-4mtysloylhnl -rfuooehlhaoe 4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-2-(2tiuoromthyiazole;
204-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-2-(2enylninthiazole; .::4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-2-benzroylaminothiazole; 2-((3,5-dichlorophenoxy)methyl)-4-(4-fluorophenyl)-5-(4- (methylsulfonyl)phenyl)thiazole; 5-(4-fluorophenyl)-4-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 1-methylsulfonyl-4-( 1, 1-dimethyl-4-(4-fluorophenyl)cyclopenta-2,4-dien-3- yl)benzene; 4-(4-(4-fluorophenyl)- 1, 1-dimethylcyclopenta-2,4-dien-3- yl)benzenesulfonamide; 5-(4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.4]hepta-4,6-diene; S4-(6-(4-fluorophenyl)spiro [2 .4lhepta-4,6-dien-5-yl)benzenesulfonamide; 76 6-(4-fluorophenyl)-2-methoxy-5-(4-(methylsulfonyl)phenyl)-pyridine-3- carbonitrile; 2-bromo-6-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-pyridine-3- carbonitrile; 6-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-phenyl-pyridine-3- carbonitrile; 4-(2-(4-methylpyridin-2-yl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; 4-(2-(5-methylpyridin-3-yl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; 4-(2-(2-methylpyridin-3-yl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; 3-(1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H-imidazol-2- yl)benzenesulfonamide; 2 -(1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-H-iyidazol-2- ylpyridine; 2-methyl-4-( 1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H-imidazol- 2-yl)pyridine; 2-methyl-6-( 1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)- iR-imidazol- 20 2-yl)pyridine; 4 -(2-(6-methylpyridin-3-yl)-4-(trifluoromethyl)-lH-imidazol-1- yl)benzenesulfonamide; 2 3 4 -difluorophenyl)-1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-lH- imidazole; 4 2 4 -methylphenyl)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonamide; 2-(4-chlorophenyl)- 1-(4-(methylsulfonyl)phenyl)-4-methyl-1H-imnidazole; 2 4 -chlorophenyl)-1-(4-(methylsulfonyl)phenyl)-4-phenyl-1H-imidazole; 2 4 -chlorophenyl)-4-(4-fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-1H- imidazole; 77 2-(3-fluoro-4-methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)-lH-imidazole; 1-(4-(methylsulfonyl)phenyl)-2-phenyl-4-trifluoromethyl-lH-iniidazole; 2-(4-methylphenyl)-1-(4-(methylsulfonyl)phenyl)-4-trifluoromethyl-1H- imidazole; 4-(2-(3-chloro-4-methylphenyl)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonamide; 2-(3-fluoro-5-methylphenyl)- 1-(4-(methylsulfonyl)phenyl)-4- (trifluoromaethyl)-lH-imidazole; 4-(2-(3-fluoro-5-methylphenyl)-4-(trifluoromethyl)- 1H-imidazol- 1- yl)benzenesulfonamide; 2-(3-methylphenyl)- 1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H- imidazole; 4-(2-(3-methylphenyl)-4-(trifluoromethyl)-1H-imidazol- 1- yl)benzenesulfonamide; 1-(4-(methylsulfonyl)phenyl)-2-(3-chlorophenyl)-4-(trifluoromethyl)- 1H- imidazole; 4-(2-(3-chlorophenyl)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonan-ide; 20 4 -(2-phenyl-4-(trifluoromethyl)-1H-imidazol-1-yl)benzenesulfonamide; 4 -(2-(4-methoxy-3-chlorophenyl)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonamide; l-allyl-4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl)- 1H-pyrazole; 4-(1-ethyl-4-(4-fluorophenyl)-5-(trifluoromethyl)- 1H-pyrazol-3- yl)benzenesulfonamide; N-phenyl-(4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5- (trifluoromethyl)-1H-pyrazol-1-yl)acetamide; ethyl (4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl)- 1H-pyrazol-1-yl)acetate; 78 4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-1-(2-phenylethyl)- 1H- pyrazole; 4-(4-fluoropheny)-3-(4-(methylsulfonyl)pheny1)-1-(2-phenylethy)-5- (trifluoromethyl)pyrazole; l-ethyl-4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl)- iR-pyrazole; 5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(trifluoromethyl)-lH- iniidazole; 4-(4-(methylsulfonyl)phenyl)-5-(2-thiophenyl)-2-(trifluoromethyl)-lH- imidazole; 5-(4-fluorophenyl)-2-methoxy-4-(4-(methylsulfonyl)phenyl)-6- (trifluoromethyl)pyridine; 2-etoxy-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-6- (trifluoromethyl)pyridine; 5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-2-ponylxy-6 (trifluoromethyl-pyridinehlufnlpey)3peyioaoe 4-bromohy-5-4-fluorophenyl-4-(4-(ezhysulfonylmpheny); 4-**(rifluoromethyl-yridin sxzl4-lbneesloai 25:: 4 -(5-3cr--meth 0 4 -fluorophenyl)-(et--y)4-(methylsulfony~hnyl)benzene; 1-di(fluoro2methyl( yloete--y)4-(methylsulfonyl)phnl--heyioao e zn 1 4 2-3-hl-5-phenylsyopol4-ltenn)4(etylfonamide; nene 1 4 2-(2-dioroehlphenylioxazon-1-yl)b4(ezenesulfonmjdezne l-( 2 -(4-trfluoromyphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; l-(2-(4-fu--methylphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; -79- l-(2-(4-fluorophenyl)-4,4-dimethylcyclopenten- l-yl)-4- (methylsulfonyl)benzene; 4 -(2-(4-fluorophenyl)-4,4-dimethylcyclopenten- 1-yl)benzenesulfonamide; l-( 2 -(4-chlorophenyl)-4,4-dimethylcyclopenten-1-yl)-4- (methylsulfonyl)benzene; 4 2 -(4-chlorophenyl)-4,4-dimethylcyclopenten- 1-yl)benzenesulfonamide; 4 2 4 -fluorophenyl)cyclopenten-1-yl)benzenesulfonamide; 4 2 -(4-chlorophenyl)cyclopenten-1-yl)benzenesulfonamide; l-( 2 -(4-methoxyphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; l-( 2 -(2,3-difluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 4 2 3 -fluoro-4-methoxyphenyl)cyclopenten-1-yl)benzenesulfonamide; 6004,00 l-( 2 3 -chloro-4-methoxyphenyl)cyclopenten-1-yl)-4- (methylsulfonyl)benzene; Vooo' 4 2 3 -chloro-4-fluorophenyl)cyclopenten-1-yl)benzenesulfonaniide; 4 2 2 -methylpyridin-5-yl)cyclopenten-1-yl)benzenesulfonamide; ethyl 2 -(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)-2- benzyl-acetate; :06. 2 4 4 -fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)acetic acid; 0000% 2 -(tert-butyl)-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazole; Soo* 2 0 4 -l o op.y 5 e h l u f ny. .n l -p e y o a o e 20 4 4 -fluorophenyl)-2my-5-(4-(methylsulfonyl)phenyl)eyoxazole;an 4 -(5-(-fluoro-mhxphenyl)-2- trfurmethyl-5-4(ehlufnl -hnloaoe n 4. AS 4 -S(-loomethod frphey)trtentorpevethnyfln-nfamatr or a phracetcall ceta ble suhtat teherf. iv feciereif 80 wherein said selective COX-2 inhibitor is selected from the group consisting of: 3 -phenyl-4-(4-(methylsulfonyl)phenyl)-2-(SH)-furanone; 3 4 -difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone; 5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3-(3-fluorophenyl)-SH-furan-2- one; 5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan.2-one; 5-chloro-3-(4-(methylsulfonyl)phenyl)-2-(2-methyl-5-pyridinyl)pyrijine; 2 -(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten1..one; 5(S)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H- fiiran-2-one; 5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(3,4-difluorophenyl..5H. furan-2-one; 2 -hialymoxy)-4-(4-(methylsulfonyl)phenyl)-5,5-dimethyl..5Hn--oe 150. furan-2-one; sodiu 20 pentenoate; 3 -(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H- 0: furan-2-one; 3 -(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-2,s- dihydrofuran-2-ol; 3 -isopropoxy-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-2,5.dihydrofuran. 2-ol; ,5-dimethyl-3-(3-fluorophenyl)-2-hydroxy-4-(4-(methylsulfonyl)phenyl)- 5-chloro-3-(4-(methylsulfonyl)phenyl)-2-(3-pyridinyl)pyridine; 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; 81 5-(4-fluorophenyl)-1- [4-(methylsulfonyl)phenyll -3- (trifluoromethyl)pyrazole; 4-(4-fluorophenyl)-5- [4-(methylsulfonyl)phenyl]-1-phenyl-3- (trifluoromethyl)pyrazole; 4-(5-(4-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(3,5-bis(4-methylphenyl)- 1H-pyrazol-1-yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-phenyl-1H-pyrazol-1-yl)benzenesulfonamide; 4-(3,5-bis(4-methoxyphenyvl)-1H-pyrazol-1-yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(4-methylphenyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(4-nitrophenyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(5-chloro-2-thienyl)-1H-pyrazol-1- yl)benzenesulfonamnide; 4-(4-chloro-3,5-diphenyl-1H-pyrazol-1-yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(5-phenyl)-3-(trifluoromethyl)-1H-pyrazol- 1-yl)benzenesulfonamlae; 20 4-(5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(5-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(difluoromethyl)-1H-pyrazol-1- ylbenzenesulfonamide; 4-(5-(4-methylphenyl)-3-(trifluoromethyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4-(4-chloro-5-(4-chloropheny1)-3-(trifluoromethy1)- 1H-pyrazol- 1- yIbenzenesulfonamide; 4-(3-(difluoromethyl)-5-(4-methylphenyl)-1H-pyrazol- 1- yl)benzenesulfonamide; STF S-S 7A 82 4-(3-(difluoromethyl)-5-phenyl- 1H-pyrazol-1-yL)benzenesulfonamide; 4-(3-(difluoromethyl)-5-(4-methoxyphenyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4 -(3-cyano-5-(4-fluorophenyl)-1H-pyrazol-1-yl)benzenesulfonamide; 4-(3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-lH-pyrazol-1- yl)benzenesulfonamide; 4-(5-(3-fluoro-4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-l- yl)benzenesulfonamide; 4-(4-chloro-5-phenyl- 1H-pyrazol-1-yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(hydroxyphenyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4 -(5-(4-(N,N-dimethylamino)phenyl)-3-(trifluoromethyl)-1H-pyrazol- 1- yl)benzenesulfonamide; 5-(4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.4lhept-5-ene; 4-(6-(4-fluorophenyl)spiro 6 4 -fluorophenyl)-7-(4-(methylsulfonyl)phenyl)spiro [3.41 oct-6-ene; 5-(3-chloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)spiro 12.4] hept- 4-(6-(3-chloro-4-methoxyphenyl)spiro 20 yl)benzenesulfonamide; 0 0 5-(3,5-dichloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)- Spiro [2.4lhept-5-ene; 5-(3-chloro-4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.41 ene; 4-(6-(3,4-dichlorophenyl)spiro 2 -(3-chloro-4-fluorophenyl)-4-(4-fluorophenyl)-5-(4- methylsulfonylphenyl)thiazole; 2 2 -chlorophenyl)- 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)thiazole; 4 -fluorophenyl)- 4 4 -methylsulfonylphenyl)-2-methylthiazole; 4 4 -fluorophenyl)-5-( 4 -methylsulfonylphenyl)-2-trifluoromethylthiazole; S 4 4 -fluorophenyl)-5-( 4 -methysulfonylpheny)-2-(2-thieny)thiazole; 83 4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-2-benzylaminothiazole; 4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-2-( 1-propylamino)thiazole; 2-((3,5-dichlorophenoxy)methyl)-4-(4-fluorophenyl)-5-(4- (methylsulfonyl)phenyl)thiazole; 5-( 4 -fluorophenyl)-4-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 1-methylsulfonyl-4-(1 ,1-dimethyl-4-(4-fluorophenyl)cyclopenta-2,4-dien-3- yl)benzene; 4-(4-(4-fluorophenyl)-1 ,1-dimethylcyclopenta-2,4-dien-3- yl)benzenesulfonamide; 5-(4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.4]hepta-4,6-diene; 4-(6-(4-fluorophenyl)spiro [2.4]hepta-4,6-dien-5-yl)benzenesulfonamide; 6 4 -fluorophenyl)-2-methoxy-5-(4-(methylsulfonyl)phenyl)-pyridine-3- carbonitrile; 2 -bromo-6-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-pyridine-3 carbonitrile; 6-( 4 -fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-phenyl-pyridine-3- carbonitrile; 4 2 4 -methylpyridin-2-yl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; 4 2 -(5-methylpyridin-3-yl)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonamide; 4 2 2 -methylpyridin-3-yl)-4-(trifluoromethyl)-1H-imidazol-l- yl)benzenesulfonamide; 3 -(l-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)- 1H-imidazol-2- yl)benzenesulfonamide; 2 -(l-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)- 1H-imidazol-2- yl)pyridine; 2 -rnethyl-4-(1-(4-(methylsulfonyl)phenyl)>4-.(trifluoromethyl)lH-imsdazolb 2 -yl)pyridine; 2-methyl-6-( 1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)- 1H-imidazol- 2 -yl)pyridine; T- C S 'Irc 84- 4 2 -(6-methylpyridin-3-yl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; 2-(3 ,4-difluorophenyl)- 1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H- imidazole; 4-(2-(4-methylphenyl)-4-(trifluoromethyl)-lH-imidazol-1- yl)benzenesulfonamide; 2-( 4 -chlorophenyl)-1-(4-(methylsulfonyl)phenyl)-4-methyl-1H-imidazole; 2-(4-chlorophenyl)-1-(4-(methylsulfonyl)phenyl)-4-phenyl-1H-imidazole; 2-( 4 -chlorophenyl)-4-(4-fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-1H- imidazole; 2 -(3-fluoro-4-methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)-1H-imidazole; l-(4-(methylsulfonyl)phenyl)-2-phenyl-4-trifluoromethyl- 1H-imidazole; 2 4 -methylphenyl)-1-(4-(methylsulfonyl)phenyl)-4-trifluoromethyl- 1H- imidazole; 4 2 -(3-chloro-4-methylphenyl)-4-(trifluoromethyl)-H-imidazol-1- yl)benzenesulfonamide; 2 -(3-fluoro-5-methylphenyl)-1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)-1H-imidazole; 20 4 2 -(3-fluoro-5-methylphenyl)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonamide; 2 3 -methylphenyl)-1-(4-(methylsulfonyl)phenyl)4(trifluoromethyl)-lH- imidazole; 4 2 -(3-methylphenyl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; l-(4-(methylsulfonyl)phenyl)-2-(3-chlorophenyl)-4-(trifluoromethyl)-1H- imidazole; 4-(2-(3-chlorophenyl)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonamide; 4-(2-phenyl-4-(trifluoromethyl)-1H-imidazol- 1-yl)benzenesulfonamide; 85 4-(2-(4-methoxy-3-chlorophenyl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; 1-allyl-4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl)- 1H-pyrazole; 4-(1-ethyl-4-(4-fluorophenyl)-5-(trifluoromethyl)-lH-pyrazol-3- yl)benzenesulfonamiide; N-phenyl-(4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5- (trifluoromethyl)-1H-pyrazol-1-yl)acetamide; ethyl (4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl)- 1H-pyrazol-1-yl)acetate; 4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-1-(2-phenylethyl)-1H- pyrazole; 4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)- 1-(2-phenylethyl)-5- (trifluoromethyl)pyrazole; l-ethyl-4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl)- 1H-pyrazole; 4 -fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(trifluoromethyl)-1H- imidazole; 4 -(4-(methylsulfonyl)phenyl)-5-(2-thiophenyl)-2-(trifluoromethyl)-lH- imidazole; S-(4-fluorophenyl)-2-methoxy-4-(4-(methylsulfonyl)phenyl)-6- (trifluoromethyl)pyridine; 2 -ethoxy-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-6- (trifluoromethyl)pyridine; 5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(2-propynyloxy)-6- (trifluoromethyl)pyridine; 2-bromo-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-6- (trifluoromethyl)pyridine; 4-(2-(3-chloro-4-methoxyphenyl)-4,5-difluorophenyl)benzenesulfonamide; 1-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)benzene; 5-difluoromethyl-4-(4-(methylsulfonyl)phenyl)-3-phenylisoxazole; 86 4-(3-ethyl-5-phenylisoxazol-4-yl)benzenesulfonamide; 4-(5-difluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 4-(5-hydroxymethyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 1-(2-(4-fluorophenyl)cyclopenten- 1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-fluoro-2-methylphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-chlorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(2,4-dichlorophenyl)cyclopenten-1-yl)4-(methylsulfonyl)benzene; 1-(2-(4-trifluoromethylphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-methylthiophenyl)cyclopenten- 1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-fluorophenyl)-4,4-dimethylcyclopenten-1-yl)-4- (methylsulfonyl)benzene; 4-(2-(4-fluorophenyl)-4,4-dimethylcyclopenten- 1-yl)benzenesulfonamidde; 1-(2-(4-chlorophenyl)-4,4-dimethylcyclopenten- l-yl)- 4 (methylsulfonyl)benzene; 4-(2-(4-chlorophenyl)-4,4-dimethylcyclopenten-1-yl)benzenesulfonamide; 4-(2-(4-fluorophenyl)cyclopenten-1-yl)benzenesulfonamide; 4-(2-(4-chlorophenyl)cyclopenten-1-yl)benzenesulfonamide; 1-(2-(4-methoxyphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(2,3-difluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 4-(2-(3-fluoro-4-methoxyphenyl)cyclopenten-1-yl)benzenesulfonamide; 1-(2-(3-chloro-4-methoxyphenyl)cyclopenten-1-yl)-4- (methylsulfonyl)benzene; 4-(2-(3-chloro-4-fluorophenyl)cyclopenten-1-yl)benzenesulfonamide; 4-(2-(2-methylpyridin-5-yl)cyclopenten- 1-yl)benzenesulfonamide; ethyl 2-(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)- 2 benzyl-acetate; 2-(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)acetic acid; 2-(tert-butyl)-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazole; 4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-phenyloxazole; -4-(4-fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)oxazole; and -87- 4 -(5-(3-fluoro-4-methoxyphenyl)-2-trifluoromethyl-4- oxazolyl)benzenesulfonamide; or a pharmaceutically acceptable salt thereof. S. S S *5*S A use according to claim 1, a composition according to claim 2, a product according to claim 3 or a method according to claim 4 wherein the NK-1 receptor antagonist is a compound of formula I: X R 4 (I) R2 N R R wherein: R 1 is selected from the group consisting of: Ci-6alkyl, substituted with one or more of the substituents selected from: S S S. the group heterocycle, wherein the heterocycle is selected from consisting of: benzimidazolyl, imidazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, pyrazinyl, pyrazolyl, pyridyl, pyrrolyl, tetrazolyl, thiadiazolyl, triazolyl, and 88 S S *5 See. *555 S C S. C ~e C S. C C S S .5CC C S S S S C C *5 piperidinyl, and wherein the heterocycle is unsubstituted or substituted with one or more substituent(s) selected from: C1-6alkyl, unsubstituted or substituted with halo, -CF 3 -OCH 3 or phenyl, (ii) Ci-6alkoxy, (iii) oxo, (iv) thioxo, cyano, (vi) -SCH 3 (vii) phenyl, (viii) hydroxy, (ix) trifluoromethyl, (x -(CH2)m-NR 9 R 10 wherein m is 0, 1 or 2, and R 9 and RIO are independently selected from: hydrogen, (II) Ci..oalkyl, (III) hydroxyCi-6alky1, and (IV) phenyl, 20 (xi) -NR 9 CORiO, wherein R9 and Rio0 are as defined above, and (xii) -CONR 9 RO, wherein R9 and RiO are as defined above, R2 and R 3 are independently selected from the group consisting of: hydrogen; Ci-6alkyl C2-alkenyl, and phenyl; X is R 4 is -89- Z M R 5 is phenyl, unsubstituted or substituted with halo; R 6 R 7 and R 8 are independently selected from the group consisting of: hydrogen, Ci-alkyl, halo, and -CF 3 Y is and Z is hydrogen or Ci-alkyl; or a pharmaceutically acceptable salt thereof. 6. A use according to claim 1, a composition according to claim 2, a product according to claim 3 or a method according to claim 4 wherein the NK-1 receptor antagonist is a compound of formula II: A YI R A (II) wherein: A 1 is fluorine or CF 3 A 2 is fluorine or CFa; A 3 is fluorine or hydrogen; R 6 is a 5-membered or 6-membered heterocyclic ring containing 2 or 3 nitrogen atoms optionally substituted by =S or a C-4alkyl group, and optionally substituted by a group of the formula ZNR7R8 where Z is Ci-6alkylene or C3-6cycloalkylene; R 7 is hydrogen, Cli4alkyl, C3-7cycloalkyl or C3-7cycloalkylCi-4alkyl, or C2-4alkyl substituted by Cl4alkoxy or hydroxyl; R 8 is hydrogen, C-4alkyl, C3-7cycloalkyl or C3-7cycloalkylC1-4alkyl, or C2-4alkyl substituted by one or two substituents selected from Cl4alkoxy, hydroxyl or a 4, 5 or 6 membered heteroaliphatic ring containing one or two heteroatoms selected from N, O and S; or R 7 R 8 and the nitrogen atom to which they are attached form a heteroaliphatic ring of 4 to 7 ring atoms, optionally substituted by a hydroxy group, and optionally containing a double bond, which ring may "optionally contain an oxygen or sulphur ring atom, a group S(0) or S(0)2 or a second nitrogen atom which will be part of a NH or NR c moiety where Rc is Ci-4alkyl optionally substituted by hydroxy or C14alkoxy; or R 7 R 8 and the nitrogen atom to which they are attached form a non-aromatic azabicyclic ring system of 6 to 12 ring atoms; or Z, R 7 and the nitrogen atom to which they are attached form a heteroaliphatic ring of 4 to 7 ring atoms which may optionally contain an oxygen ring atom; X is an alkylene chain of 1 to 4 carbon atoms optionally substituted by oxo; and Y is a C14alkyl group optionally substituted by a hydroxyl group; with the proviso that ifY is C-4alkyl, R 6 is susbstituted at least by a group of formula ZNR 7 R 8 as defined above; or a pharmaceutically acceptable salt thereof. 7. A use according to claim 1, a composition according to claim 2, a product according to claim 3 or a method according to claim 4 wherein the NK-1 receptor antagonist is a compound of formula III: -91- 2 J, Z R (III) R N R (0)P A I 12 R 13 R 12 wherein: R 2 and R 3 are independently selected from the group consisting of: hydrogen, C1-6alkyl, C2-6alkenyl, and phenyl; R 6 R 7 and R 8 are independently selected from the group consisting of: hydrogen, C1-6alkyl, fluoro, chloro, 15 bromo, iodo, and -CF 3 R 1 R 12 and R 1 3 are independently selected from the group consisting of: fluoro, chloro, bromo, and iodo; A is unsubstituted 1-6alkyl; B is selected from the group consisting of: -92- N-9 N x H N-N N I x x N-N N 0 H N-N N H N-N N 0 H N-N N 0 X\ H N-N N-N a r r r x N-N N x 1 N H H N x N-N N x N N x N 0 1 x H 'N x N H H N S N S p is O or 1; X is selected from: -PO(OH)O- e wherein M+ is a pharmaceutically acceptable monovalent counterion, -PO(O-) 2 2M+, -PO(O-) 2 D2+, wherein D 2 is a pharmaceutically acceptable divalent counterion, -CH(R 4 )-PO(OH)O- wherein R 4 is hydrogen or C1.3alkyl, -CH(R4)-PO(O) 2 2M+, -CH(R4)-PO(O-) 2 D2+, -CO-CH 2 CH 2 -C0 2 M+, -93- -CH(CH 3 )-O-CO-R 5 wherein R 5 is selected from the group consisting of: NH M H2 M ONN, OH 0 CO 2 M CO02M' O NCO NH: .CO2 M 9 C. 9* 9* (vii) Co 2 -M+ 0- and Y is and Z is hydrogen or C1-6alkyl; or a pharmaceutically acceptable salt thereof. 8. A use according to claim 1, a composition according to claim 2, a product according to claim 3 or a method according to claim 4 wherein Wit he NK-1 receptor antagonist is a compound of formula IV: 94- (IV) K.N H d wherein R' represents hydrogen, hydroxy, Ci..oalkyl, C2-6alkenyl, C3-7'cycloalkyl, C3-7cycloalkylCl-4alkyl, C1.6alkoxy, fluoroCi.ealkoxy, Ci..oalkoxyCli4alkyl, Cl-6alkoxyCi-4alkoxy, fluoroC1-6alkoxyCl-4alkyl, C2-6alkenyloxy, C3..7CYCloalkoxy, C3-7CYCloalkylCl-4alkoxy, phenoxy, 10 benzyloxy, cyano, halogen, NRaRb, SRa, SORa, SO 2 Ra, OSO 2 R1a, NRaCORl 4 CORa, CO 2 Ra or CONRaRb where Ra and Rb each independently represent hydrogen, C1-4alkyl or fluoroCl-4alkyl; R 2 represents hydrogen, halogen, C1-6alkyl or Cl-6alkoxy; or Ri and R 2 may be joined together such that there is formed a 5- or 15 6-membered saturated or unsaturated ring containing one or two atoms selected from nitrogen, oxygen and sulphur, which ring is optionally substituted by a group selected from Ci-4alkyl, CF 3 =0 or =S; *R 3 represents hydrogen, halogen, CI-6alkyl, fluoroCl-6alkyl, C1-6alkoxy, fluoroCi-6alkoxy, C3-7cycloalky1, Ca-7cycloalkylCi~alkyl, cyano, SRa, SORa, SO 2 Ra, NRaRb, NRaCORl 4 CORa, CO 2 Ra, CONRaRb or Ci-4alkyl substituted by cyano, CO 2 Ra or CONRaRb where Ra and Rb are as previously defined; R 4 represents hydrogen, halogen, C1.6alkyl, C1i6alkoxy, CF 3 OCF 3 NO 2 CN, SRa, SORa, SO 2 Ra, CO 2 Ra, CONRaRb, C2-6alkenyl, C2-6alkynyl or Ci~alkyl substituted by C1-4alkoxy, where Ra and Rb are as previously defined; and the broken line represents an optional double bond; or a pharmaceutically acceptable salt thereof. 9. A use according to claim 1, a composition according to claim 2, a product according to claim 3 or a method according to claim 4 wherein the NK-1 receptor antagonist is a compound of formula V: R 7 R N R 2 (V) R e R R or a pharmaceutically acceptable salt thereof, wherein S: Y is (CH 2 )n wherein n is an integer from 1 to 4, and wherein any one S 10 of the carbon-carbon single bonds in said (CH 2 )n may optionally be replaced by a carbon-carbon double bond, and wherein any one of the carbon atoms of said (CH 2 )n may optionally be substituted with R 4 and wherein any one of the carbon atoms of said (CH 2 )n may optionally be substituted with R 7 15 Z is (CH 2 )m wherein m is an integer from 0 to 6, and wherein any one of the carbon-carbon single bonds of (CH 2 )m may optionally be replaced by a carbon-carbon double bond or a carbon-carbon triple bond, and any one of the carbon atoms of said (CH 2 )m may optionally be substituted with R8; R 1 is hydrogen or C-l.alkyl optionally substituted with hydroxy, C14alkoxy or fluoro; R 2 is a radical selected from hydrogen, C 1 i straight or branched alkyl, C3-7cycloalkyl wherein one of the CH 2 groups in said cycloalkyl may optionally be replaced by NH, oxygen or sulphur; aryl selected from phenyl and naphthyl; heteroaryl selected from indanyl, thienyl, furyl, pyridyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, tetrazolyl and 96 quinolyl; phenyl-C2-6alkyl, benzhydryl and benzyl, wherein each of said aryl and heteroaryl groups and the phenyl moieties of said benzyl, phenyl C2-6alkyl and benzhydryl may optionally be substituted with one or more substituents independently selected from halo, nitro, C1..6 alkyl, C1..6alkoxy, trifluoromethyl, amino, Obo6alkylamino, Cl-6alkyl-O-CO, CI-6alkyl-O-CO- Ci..oalkyl, Ci..oalkyl-CO-O, Cio6alkyl-CO-Cl-6alkyl-O-, C1..6alkyl-CO, Ci..oalkyl-CO-Ci-6alkyl-, di-Ci..oalkylamino, -CONH-CI..oalkyl, Ci..oalkyl-CO-NH-Ci-6alkyl, -NHCOH and -NHCO-Cr-6alkyl; and wherein one of the phenyl moieties of said benzhydryl may optionally be replaced by naphthyl, thienyl, furyl or pyridyl; is hydrogen, phenyl or Ci..oalkyl; or R 2 and R5 together with the carbon to which they are attached, form a saturated ring having from 3 to 7 carbon atoms wherein one of the OH 2 groups in said ring may optionally be replaced by oxygen, NH or 15 sulfur; R 3 is aryl selected from phenyl and naphthyl; heteroaryl selected from indanyl, thienyl, furyl, pyridyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, tetrazolyl and quinolyl; and cycloalkyl having 3 to 7 carbon atoms wherein one of the (CH 2 groups in said cycloalkyl. may 20 optionally be replaced by NH, oxygen or sulphur; wherein each of said aryl and heteroaryl groups may optionally be substituted with one or more substituents, and said C3..7cycloalkyl may optionally be substituted with one or two substituents, each of said substituents being independently selected from halo, nitro, Ci..oalkyl, CI-6alkoxy, trifluoromethyl, amino, C1.6alkylamino, -CO-NH- C1..6alkyl, C1.6alkyl-CO-NH-Clo6alkyl, -NHCOH and -NHCO-Ci.oalkyl; R 4 and R 7 are each independently selected from hydroxy, halogen, halo, amino, oxo, cyano, methylene, hydroxymethyl, halomethyl, Ci..oalkylamino, di-Cl-6alkylamino, Ci..oalkoxy, Cl-6alkyl-O-CO, Clioalkyl-O-CO-Clioalkyl, Ci-6alkyl-CO-O, Clioalkyl-CO-C 1-6alkyl-O-, -97- Clialkyl-CO-, Ci-6alkyl-CO-Cl-ealkyl, and the radicals set forth in the definition of R 2 R 6 is -NHCOR S -NHCH 2 R 9 S0 2 R8 or one of the radicals set forth in any of the definitions of R 2 R 4 and R 7 R8 is oximino (=NOH) or one of the radicals set forth in any of the definitions of R2, R4 and R 7 R 9 is Ci-ealkyl, hydrogen, phenyl or phenylCl-alkyl; with the proviso that when m is 0, R s is absent, when R 4 R 6 R 7 or R 8 is as defined in R 2 it cannot form together with the carbon to which it is attached ,a ring with R 5 and when R 4 and R 7 are attached to the same carbon atom, then either each of R 4 and R 7 is independently selected from hydrogen, fluoro and Cl-6alkyl, or R 4 and R 7 together with the carbon :i to which they are attached, for a C3-6 saturated carbocyclic ring that forms a spiro compound with the nitrogen-containing ring to which they are 15 attached; or a pharmaceutically acceptable salt thereof. A use according to claim 1, a composition according to claim 2, a product according to claim 3 or a method according to claim 4 wherein S 20 the NK-1 receptor antagonist is a compound of formula VI: N ICH-R 1 (VI) R 5 12 R R' R 4 wherein: radicals R are phenyl radicals optionally 2- or 3-substituted by a halogen atom or a methyl radical; R 1 is optionally substituted phenyl, cyclohexadienyl, naphthyl, indenyl or optionally substituted heterocycle; -98- R 2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, optionally substituted alkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino; R 3 is optionally 2-substituted phenyl; R 4 is OH or fluorine when R 5 is H; or R 4 and R 5 are OH; or R 4 and R 5 together form a bond; or a pharmaceutically acceptable salt thereof. 11. A use according to claim 1, a composition according to claim 2, a product according to claim 3 or a method according to claim 4 wherein the NK-1 receptor antagonist is a compound of formula VII: *R Q Ar-T-CO- -CH 2 -C-CH 2 -CH-Am A- (VII) Ar' wherein: Ar represents an optionally substituted mono-, di- or tricyclic aromatic or heteroaromatic group; T represents a bond, a hydroxymethylene group, a 20 C14alkoxymethylene group or a Cl-5alkylene group; Ar' represents a phenyl group which is unsubstituted or substituted by one or more substituents selected from halogen, preferably chlorine or fluorine, trifluoromethyl, C14alkoxy, C14alkyl where the said substituents may be the same or different; a thienyl group; a benzothienyl group; a naphthyl group; or an indolyl group; R represents hydrogen, C1-4alkyl, o)-Ci4alkoxyC14alkyl, or )-C2-4alkanoyloxyC2-4alkyl; Q represents hydrogen; -99- or Q and R together form a 1,2-ethylene, 1,3-propylene or 1,4- butylene group; Am represents the radical 2 1, in which X 1 X 2 and Xa, together with the nitrogen atom to which they are attached, form an azabicyclic or azatricyclic ring system optionally substituted by a phenyl or benzyl group; and A- represents a pharmaceutically acceptable anion. 12. A use according to claim 1, a composition according to claim 2, a product according to claim 3 or a method according to claim 4 wherein the NK-1 receptor antagonist is a compound of formula VIII R 3 R 1 (VIII) R---X wherein: 15 R 1 represents an optionally substituted aralkyl, aryloxyalkyl, 'heteroaralkyl, aroyl, heteroaroyl, cycloalkylcarbonyl, aralkanoyl, S. heteroarylalkanoyl, aralkoxycarbonyl or arylcarbamoyl group or the acyl C group of an a-amino acid optionally N-substituted by a lower alkanoyl or carbamoyl-lower alkanoyl group; R 2 represents cycloalkyl or an optionally substituted aryl or heteroaryl group; R 3 represents hydrogen, alkyl, carbamoyl or an alkanoyl or alkenoyl group optionally substituted by carboxy or esterified or amidated carboxy; R 4 represents an optionally substituted aryl group or an optionally partially saturated heteroaryl group; -100- X 1 represents methylene, ethylene, a bond, an optionally ketalised carbonyl group or an optionally etherified hydroxymethylene group; X 2 represents alkylene, carbonyl or a bond; and X 3 represents carbonyl, oxo-lower alkyl, oxo(aza)-lower alkyl, or an alkyl group optionally substituted by phenyl, hydroxymethyl, optionally esterified or amidated carboxy, or (in other than the a-position) hydroxy; or a pharmaceutically acceptable salt thereof. 13. A use according to claim 1, a composition according to claim 2, a product according to claim 3 or a method according to claim 4 wherein the NK-1 receptor antagonist is a compound of formula IX: R 3 R -Y-A-N CONHCHCON (IX) 15 wherein: S z X is CH or N; and Z is 0 or N-R 5 in which R 5 is hydrogen or lower alkyl; R2 is hydroxy or lower alkoxy; R 3 is hydrogen or optionally substituted lower alkyl; R4 is optionally substituted ar(lower)alkyl; A is carbonyl or sulfonyl; and Y is a bond or lower alkenylene; or a pharmaceutically acceptable salt thereof. -101- 14. A use according to claim 1, a composition according to claim 2, a product according to claim 3 or a method according to claim 4 wherein the NK-1 receptor antagonist is a compound of formula X: H 1 N R2 H (X) wherein: R 1 is aryl selected from indanyl, phenyl and naphthyl; heteroaryl selected from thienyl, furyl, pyridyl and quinolyl; and cycloalkyl having 3 to 7 carbon atoms, wherein one of said carbon atoms may optionally be 10 replaced by nitrogen, oxygen or sulfur; wherein each of said aryl and heteroaryl groups may optionally be substituted with one or more substituents, and said C3-7cycloalkyl may optionally be substituted with one or two substituents, said substituents being independently selected from chloro, fluoro, bromo, iodo, nitro, Cl-ioalkyl optionally substituted with from one to three fluoro groups, Ci-loalkoxy optionally substituted with from one to three fluoro groups, amino, Ci-loalkyl-S-, Cli-oalkyl-S(O)-, Ci-ioalkyl-S0 2 phenyl, phenoxy, Cl-loalkyl-SO 2 NH-, S:Ci-loalkyl-SO 2 NH-C-loakyl-, Ci-loalkylamino-diCi-loalkyl-, cyano, hydroxy, cycloalkoxy having 3 to 7 carbon atoms, Ci-ealkylamino, Cledialkylamino, 20 HC(O)NH- and Cl-loalkyl-C(O)NH-; and R 2 is thienyl, benzhydryl, naphthyl or phenyl optionally substituted with from one to three substituents independently selected from chloro, bromo, fluoro, iodo, cycloalkoxy having 3 to 7 carbon atoms, Ci-loalkyl optionally substituted with from one to three fluoro groups and Ci-loalkoxy optionally substituted with from one to three fluoro groups; or a pharmaceutically acceptable salt thereof. -102- A use according to claim 1, a composition according to claim 2, a product according to claim 3 or a method according to claim 4 wherein the NK-1 receptor antagonist is a compound of formula XI: R 2 I H N -R R wherein: R 1 is a C-4alkoxy group; R 2 is 6 N N I N N-N 10 R 3 is a hydrogen or halogen atom; R 4 and R 5 may each independently represent a hydrogen or halogen atom, or a C-4alkyl, C-4alkoxy or trifluoromethyl group; R 6 is a hydrogen atom, a Ci-4alkyl, (CH2)mcyclopropyl, -S(O)nCl4alkyl, phenyl, NR 7 R 8 s CH 2 C(O)CF 3 or trifluoromethyl group; R 7 and R8 may each independently represent a hydrogen atom, or a Cl4alkyl or acyl group; x represents zero or 1; n represents zero, 1 or 2; and m represents zero or 1; or a pharmaceutically acceptable salt thereof. 103 16. A use according to claim 1, a composition according to claim 2, a product according to claim 3 or a method according to claim 4 wherein the NK-1 receptor antagonist is a compound of formula XII: R8 R4 NH 1I (XII) wherein: m is zero, 1, 2 or 3; n is zero or 1; o is zero, 1 or 2; p is zero or 1; R is phenyl, 2- or 3-indolyl, 2- or 3-indolinyl, benzothienyl, benzofuranyl, or naphthyl; which R groups may be substituted with one or two halo, C1..3alkoxy, trifluoromethyl, CI-4alkyl, phenyl-Cl-3alkoxy, or Ci-4alkanoyl groups; R1 is trityl, phenyl, diphenylmethyl, phenoxy, phenylthio, piperazinyl, piperidinyl, pyrrolidinyl, morpholinyl, indolinyl, indolyl, benzothienyl, hexamethyleneiminyl, benzofuranyl, tetrahydropyridinyl, quinolinyl, isoquinolinyl, reduced quinolinyl, reduced isoquinolinyl, phenyl-(Ci-4alkyl)-, phenyl-(Ci-4alkoxy)-, quinolinyl-(Cl-4alkyl)-, isoquinolinyl-(Cl-4alkyl)-, reduced quniolinyl-(Cl-4alkyl)-, reduced isoquinolinyl-(CI- 4 alkyl)-, benzoyl-(C1..3alkyl)-, Ci-4alkyl, or -NH-CH2-R 5 any one of which R' groups may be substituted with halo, Ci4alkyl, C14alkoxy, trifluoromethyl, amino, Ci-4alkylarnino, di(Ci-4alkyl)amnino, or C2A4alkanoylamino; 104 or any one of which R' groups may be substituted with phenyl, piperazinyl, C3a8cycloalky1, benzyl, Ci-4alkyl, piperidinyl, pyridinyl, pyrimidinyl, C26alkanoylamnino, pyrrolidinyl, C2..alkanoyl, or Cl-4alkoxycarbonyl; any one of which groups may be substituted with halo, Cl4alkyl, Cl-4alkoxy, trifluoromethyl, amino, C1-4alkylamino, di(Cl-4alkyl)amino, or C2A4alkanoylamino; or R' is amino, a leaving group, hydrogen, Ci-4alkylamino, or di(Cl-4alkyl)amino; R 5 is pyridyl, anilino-(Cl-3alkyl)-, or anilinocarbonyl; R 2 is hydrogen, Cl-4alkyl, Cl-4alkylsulfonyl, carboxy-(Ci..aalkyl)-, Cl-alkoxycarbonyl-(Cl.3alkyl)-, or -CO-R6; R 6 is hydrogen, Ci-4alkyl, Cl..3haloalkyl, phenyl, Cka3alkoxy, Ci-3hydroxyalkyl, amino, Cl-4alkylamnino, di(Ci-4alkyl)amino, or -(CH2)q-R 7 15 q is zero to 3; R 7 is carboxy, Cl-4alkoxycarbonyl, Ci-4alkylcarbonyloxy, amino, Cl-4alkylamino, di(Cl-4alkyl)amino, C1.6alkoxycarbonylamino, or phenoxy, phenylthio, piperazinyl, piperidinyl, pyrrolidinyl, morpholinyl, indolinyl, indolyl, benzothienyl, benzofuranyl, quinolinyl, phenyl-(Ci-4alkyl)-, see*.: 20 quinolinyl-(Cl-4alkyl)-, isoquinolinyl-(Cl-4alkyl)-, reduced quinolinyl- ~~(Ci-4alkyl)-, reduced isoquinolinyl-(iakl- ezy-1.akl :aa any one of which aryl or heterocyclic R 7 groups may be substituted with halo, trifluoromethyl, Ci-4alkoxy, C1-4alkyl, amino, Ci-4alkylaMino, di(Cl-4alkyl)amino, or C2A4alkanoylamino; or any one of which R7 groups may be substituted with phenyl, piperazinyl, C3..8cycloalkyl, benzyl, piperidinyl, pyridinyl, pyrimidinyl, pyrrolidinyl, C2.6alkanoyl, or Cl-4alkoxycarbonyl; any of which groups may be substituted with halo, trifluoromethyl, amino, C1..4alkoxy, Ci-4alkyl, Ci-4alkylamino, di(Ci-4alkyl)amino, or C2-4alkanoylamino; R8 is hydrogen or C1-6alkyl; 105 RWis phenyl, phenyl-(Ci-6alkyl)-, C3.8cycloalkyl, C1..8alkyl, naphthyl, C2-8alkenyl, or hydrogen; any one or which groups except hydrogen may be substituted with one or two halo, Cisalkoxy, Ci..salkylthio, nitro, trifluoromethyl, or Ci..3alkyl groups; and R 4 is hydrogen or Ci-3alkyl; with the proviso that if R' is hydrogen or halo, RWis phenyl, phenyl-(Ci-6alkyl)-, C3acycloalkyl, C5.acycloalkenyl, or naphthyl; or a pharmaceutically acceptable salt thereof. *17. A use, composition, product or method according to any one of the preceding claims wherein the NK-1 receptor antagonist is orally active, long acting and CNS-penetrant. 6 15 18. A use according to claim 1, a composition according to claim 2, a product according to claim 3 or a method according to claim 4 wherein the NK-1 receptor antagonist is selected from the classes of compounds described in EP-A-0577394, WO-A-9508549, WO-A-9518124, WO-A-9523798 or WO-A-9605181. *Gt: *006 19. A use according to claim 1, a composition according to claim *O 2, a product according to claim 3 or a method according to claim 4 wherein the NK-1 receptor antagonist is selected from 4 3 2 4 -triazolo)methyl)-2(S)-(3,5-bis(trifluoromethyl)benzyloxcy)-3(S) phenyl-morpholine; l, 2 4 -triazolo)methyl)-2(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3(R)- phenyl-morpholine; 4 3 -(5-oxo-1H,4H- 1,2,4-triazolo)methyl)-2(S)-(3,s.. bis(trifluoromethyl)benzyloxy)-3(S)-phenyl.morpholine; .2()(-R-35bstilooehlpey~toy--S-4furpey) 4 3 -(5-oxo- 1H,4H-1 2 4 -triazolo)methyl)morpholine; 106 1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(5-(dimethyla-ino) methyl-i ,2,3-triazol-4-yl)methyl-3-(S)-phenylmorpholine; 1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(5-(dimethylamjno) methyl-1,2,3-triazol-4-yl)methy-3-(S)-(4-fluorophenyl)morpholine; 1-(S)-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethoxy)-3-(S)-(4- fluorophenyl)-4-(1,2,4-triazol-3-yl)methylmorpholine; 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(3-(5-oxo-lH,4H. 1,2,4-triazolo)methyl)morpholine N-oxide; 2-(S)-(3,5-bis(trifluoromethyl)benzyloxy)-3-(S)-phenyl-4-(3-(4- (ethoxycarbonyloxy-1-ethyl)-5-oxo-1H-1,2,4-triazolo)methyl)morpholine; 1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4 3 4 -monophosphoryl-5-oxo-1H-1,2,4-triazolo)methyl)morpholine; 1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 1-monophosphoryl-5-oxo-1H- 1,2,4-triazolo)methyl)morpholine; 2 -(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl). 4-(3-(2-monophosphoryl-5-oxo-1H-1 ,2,4-triazolo)methyl)morpholine; l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 4 3 -(5-oxyphosphoryl-1H-1,2,4-triazolo)methyl)morpholine; l-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluorophenyl)- 20 1-monophosphoryl-5-oxo-4H-1 ,2,4-triazolo)methyl)morpholine; 3 R,5R,6S)-3-(2-methoxy-5-(trifluoromethoxy)phenyl)-6-phenyl-1-oxa-7- aza-spiro [4.Sldecane; (3R,5R,6S)-3-(2-methoxy-5-(trifluoromethyl)phenyl)-6-phenyl- 1-oxa-7-aza- Spiro (3R,5R,6S)-7-benzyl-3- [2-methoxy-5-(trifluoromethoxy)pheny1lJ-6-phenyl- 1- oxa-7-aza-spiro decane; (3R, 5R,6S)-3-(2-methoxy-5-trifluoromethoxyphenyl)-6-phenyl- 1-oxa-7-aza- Spiro [4.51 decane; (3R, 5R,6S)-3 ,6-bis(phenyl)- 1-oxa-7-aza-spiro decane; (3R,5R,6S)-7-benzyl-3-(2-methoxy-5-trifluoromethoxyphenyl)-6-phenyl- 1- oxa-7-aza-spiro decane; 107 (t)-3R*5R*,S*)3-(-metoxyhenl)-6pheyl1-oxa-7- (phenylmethoxycarbonyl)aza-spiro decane; (3R,5R,6S)-3-(2-methoxyphenyl)-6-phenyl-1-oxa-7-aza-spiro (3S, 5R,6S)-3-(2-cyclopropoxy-5-(trifluoromethoxy)phenyl)-6-phenyll1oxa. 7-aza-spiro [4.51 decane; (3R, 5R,6S)-3- [2-cyclopropoxy-5-(trifluoromethoxy)phenyll -6-phenyl-1-oxa- 7-aza-spiro [4.51 decane; (3S, 5R [2-cyclopropoxy-5-(trifluoromethyl)phenyl -6-phenyl- 1-oxa-7- aza-spiro decane; se. 10 (2S,3S)-cis-3-(2-methoxybenzylamino)-2-phenylpiperidine; (3aS, 4S, 7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2- methoxyphenyl)propionyl] perhydroisoindol-4-ol; see+ 1- [3-(3,4-dichlorophenyD- 1- [(3-isopropoxyphenyl)acetylJ -3- piperidinyl] ethyl] -4-phenyl-1-azabicyclo [2,2,21 octane; 4S)2bny--35dmtybnol--4qioiymty)4 piperidineamine; HO~ /NN 2 S,3S)-3-(2-methoxy-5-trifluoromethoxybenzy)..amno.2 phenylpiperidine; 2 -methoxy-5-tetrazol-1-yl-benzyl)-( [2S,3S] -2-phenyl-piperidin-3-yl)-amine; 2 -methoxy-5-(5-trifluoromethyl-tetrazol- 1-yl)-benzyl] [2S,3S] -2-phenyl- piperidin-3-yl)-amine; and [N-(2-methoxybenzyl)acetylaminol 1H-indol-3-yl)-2- [N-(2-(4-piperidin- 1- yl)piperidin-1-yl)acetylaminolpropane; a pharmaceutically acceptable salt thereof. 108 A process for preparing a pharmaceutical composition comprising combining a selective COX-2 inhibitor and a NK-1 receptor antagonist with a pharmaceutically acceptable carrier, wherein said selective COX-2 inhibitor is selected from the group consisting of: 3 -phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)..furanone; 3 3 4 -difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)4furanone; 5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3-(3-fluorophenyl)Hfuran2- one; 5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy).5H.furan2one; 3 4 -(methylsulfonyl)phenyl)-2-(2-methyl..spyridinyl)pyridine; 2-(3 ,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2cyclopenten-1-one; (S)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)3(2-propoxy)-5H- furan-2-one; 5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3(3,4..difluorophenyl)-5H- furan-2-one; 3 2 -thiazolyl)methoxy)-4-(4-(methylsulfonyl)phenyl)-,.dimethyl.5H- furan-2-one; 3 -propyloxy- 4 4 -(methylsulfonyl)phenyl)-5,s..dimethylbsH-uran2-one; 3 -(l-cyclopropylethoxy)-5,5-dimethyl4(4-methylsulfonyl)phenyl).5H- ftiran-2-one; .:sodium 2 4 -chlorophenyl)-3-(4-(methylsulfonyl)phenyl)4oxo-2 pentenoate; 3 -(cyclopropylmethoxy)-5,s-dimethyl.4(4..(methylsulfonyl)phenyl).SH furan-2-one; 3 -(cyclopropylmethoxy)-,5-.dimethyl.4-.(4.(methylsulfonyl)phenyl..2,5-. dihydrofuran-2-ol; 3 -isopropoxy-5,5-dimethyl-4(4-.(methylsulfonyl)phenyl)>25-dihydrofuran. 2-ol; 5,5-dimethyl- 3 -(3-fluorophenyl).2hydroxy-4-.(4-(methylsulfonyl)phenyl). 2 109 5-chloro-3-(4-(methylsulfonyl)phenyl)-2-(3-pyridinyl)pyridine; 4 -(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; 5-(4-fluorophenyl)-1- [4-(methylsulfonyl)phenyl] -3- (trifluoromethyl)pyrazole; 4-(4-fluorophenyl)-5- [4-(methylsulfonyl)phenyl] -1-phenyl-3- (trifluoromethyl)pyrazole; 4-(5-(4-chlorophenyl)-3-(4-methoxyphenyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4-(3,5-bis(4-methylphenyl)- 1H-pyrazol-1-yl)benzenesulfonamide; 4 4 -chlorophenyl)-3-phenyl-1H-pyrazol-1-yl)benzenesulfonamide; 4-(3,5-bis(4-methoxyphenyl)- 1H-py-razol- 1-yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-(4-methylphenyl)- 1H-pyrazol- 1- yl)benzenesulfonainide; 4 -(5-(4-chlorophenyl)-3-(4-nitrophenyl)-1H-pyrazol- 1- yl)benzenesulfonam-ide; 4 4 -chlorophenyl)-3-(5-chloro-2-thienyl)-1H-pyrazol-l- yl)benzenesulfonaniide; 4 4 -chloro-3,5-diphenyl-lH-py-razol-1-yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1- 20 yl)benzenesulfonamide; 4-(5-phenyl)-3-(trifluoromethyl)- iR-pyrazol- 1-yl)benzenesulfonamide; a. 4 -(5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-l- yl)benzenesulfonamide; 4-(5-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(difluoromethyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(5-(4-methylphenyl)-3-(trifluoromethyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4 4 -chloro-5-(4-chlorophenyl)-3-(trifluoromethyl)1lHpyrazopl-.. yl)benzenesulfonamide; 110 4 -(3-(difluoromethyl)-5-(4-methylphenyl)-lH-pyrazol-l-. yl)benzenesulfonamide; 4-3(ilooehl--hnll-przl1y~eznsloaie 4 -(3-(difluoromethyl)-5-(4-methoxyphenyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4-3cao5(-loohnl-Hprzl1y~eznsloaie 4 3 -(difluoromethy)-5-(3-fluoro-4-methoxypheny)-lH-pyrazol-l-. yl)benzenesulfonamide; 4 3 -fluoro-4-methoxypheny)-3-(trifluoromethy).1Hpyrazol-l- yl)benzenesulfonamide; 4-4clr--hnll-yazl1y~eznsloaie 4 4 -chlorophenyl)-3-(hydroxyphenyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4 4 -(N,N-dimethylamino)pheny1)-3-(trifluoromethyl)1lH.pyazol-l-1 yl)benzenesulfonamide; 4 -fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.4lhept-5-ene; 4 6 4 -fluorophenyl)spiro 2 4 6 4 -fluorophenyl)-7-(4-(methylsulfonyl)phenyl)spiro[13.41 oct-6-ene; 3 -chloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.4lhept- 20 4 6 3 -chloro-4-methoxyphenyl)spiro [2.4]hept-5-en-5- yl)benzenesulfonamide; 3 ,S-dichloro-4-methoxypheny)-6-(4-(methylsulfony)pheny). spiro [2.41 5-( 3 -chloro-4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.41 ene; 4-(6-(3,4-dichlorophenyl)spiro 2 4 2 -(3-chloro-4-fluorophenyl)-4-(4-fluorophenyl)-5-(4. methylsulfonylphenyl)thiazole; 2 2 -chlorophenyl)- 4 4 -fluoropheny)-5-(4-methylsulfonylpheny1)thiazole; 4 -fluorophenyl)- 4 4 -methylsufonylpheny)-2-methylthiazole; ill 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-(2-thienyl)thiazole; 4 -(4-fluorophenyl)-5-(4-methylsulfonylpheny1)-2-benzylaininothiazole; 4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-2-( 1-propylamino)thiazole; 2-((3,5-dichlorophenoxy)methyl)-4-(4-fluorophenyl)-5-(4- (methylsulfonyl)phenyl)thiazole; 5-(4-fluorophenyl)-4-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 1-methylsulfonyl-4-( 1, 1-dimethyl-4-(4-fluorophenyl)cyclopenta-2,4-dien-3- yl)benzene; 4-(4-(4-fluorophenyl)-1 ,1-dimethylcyclopenta-2,4-dien-3- yl)benzenesulfonamide; 5-(4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro hepta-4,6-diene; 4-(6-(4-fluorophenyl)spiro [2 .4lhepta-4,6-dien-5-yl)benzenesulfonamide; 6-( 4 -fluorophenyl)-2-methoxy-5-(4-(methylsulfonyl)phenyl)-pyridine-3- carbonitrile; 2 -bromo-6-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-pyridine-3- carbonitrile; 6-( 4 -fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-phenyl-pyridine-3- carbonitrile; 20 4 -(2-(4-methylpyridin-2-yl)-4-(trifluoromethyl)- 1H-imidazol-1- ylbenzenesulfonamide; 4 2 -(5-methylpyridin-3-yl)-4-(trifluoromethyl)-1H-imidazol-l- yl)benzenesulfonamide; 4 -(2-(2-methylpyridin-3-yl)-4-(trifluoromethyl)- 1H-imnidazol- 1- yl)benzenesulfonamide; l-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)- 1H-imidazol-2- yl)benzenesulfonamide; l-( 4 -(methylsulfonyl)phenyl)-4-(trifluoromethyl)1lH-imidazob2- yl)pyridine; 2-methyl-4-( l-( 4 -(methylsulfonyl)phenyl)-4-(trifluoromethyl) 1H-imidazol- 2-yl)pyridine; 112 2-methyl-6-( 1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-lH-iiazol. 2-yl)pyridine; 4 2 -(6-methylpyridin-3-yD)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonamide; 2 4 -difluorophenyl)-1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)1lH imidazole; 4 4 -methylphenyl)-4-(trifluoromethyl)-1H-imidazol-l- yl)benzenesulfonamide; 2 4 -chlorophenyl)--(4-(methylsulfonyl)phenyl)-4-methyllH-imidazole; 2-(4-chlorophenyl)- l-(4-(methylsulfonyl)phenyl)-4-phenyl-lH-imidazole; 2 4 -chloropheny)-4-(4-fluoropheny)--(4.(methysufony)pheny)-.1H imidazole; 2 -(3-fluoro-4-methoxyphenyl)- 1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)- 1H-imidazole; l-( 4 -(methylsulfonyl)phenyl)-2-phenyl-4-trifluoromethylblH.inidazole; 2-(4-methylphenyl)- l-( 4 -(methylsulfonyl)phenyl)-4-trifluoromethyl.H. imidazole; 4 2 -(3-chloro-4-methylpheny)-4-(trifluoromethy)-Himdazo...1. yl)benzenesulfonamide; 2 3 -fluoro-5-methylpheny)-l-(4-(methylsulfony)pheny>.4. (trifluoromethyl)-1H-inudazole; 4 2 -(3-fluoro-5-methylphenyl)-4-(trifluoromethyl)-lH-imidazol-l-. yl)benzenesulfonamide; 2-(3-methylphenyl)- 1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-H. imidazole; 4-( 2 -(3-methylphenyl)-4-(trifluoromethyl)-lH-imidazol-l- yl)benzenesulfonamide; l-(4-(methylsulfonyl)phenyl)-2-(3-chlorophenyl)-4-(trifluoromethyl)- 1H- imidazole; 4-(2-(3-chlorophenyl)-4-(trifluoromethyl)- 1H-imidazol- 1- yl)benzenesulfonamide; 113 4 2 -phenyl- 4 -(trifluoromethyl)-1H-imidazol-1-yl)benzenesulfonamide; 4 2 -(4-methoxy-3-chlorophenyl)-4(trifluoromethy)1Himdazol-l-. yl)benzenesulfonamide; l-allyl- 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl). 1H-pyrazole; yl)benzenesulfonamide; N-phenyl-(4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl..s. (trifluoromethyl)-1H-pyrazol-1-yl)acetamide; ethyl 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl).5-(trifluoromethyl). lH-pyrazol-1-yl)acetate; 4 4 -fluorophenyl)-3-(4-(methylsufonyl)phenyl)i...(2.phenylethyl)lH- pyrazole; 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)..1.(2..phenylethyl).s.. (trifluoromethyl)pyrazole; l-ethyl- 4 -(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5..(tirifluoromethyl). IH-pyrazole; 4 -fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(trifluoromethyl). H- imidazole; 20 4 4 -(methylsulfonyl)phenyl)-5-(2-thiophenyl>2-(trifluoromethyl) 1H- imidazole; 4 -fluorophenyl)-2-methoxy-4-(4-(methylsulfonyl)phenyl).6 (trifluoromethyl)pyridine; 2 -ethoxy-5-(4-fluorophenyl)4(4-(methylsufonyl)pheny)-6- (trifluoromethyl)pyridine; 4 -fluorophenyl)-4-4-(methylsulfonyl)phenyl)2(2-propyyloxy..6- (trifluoromethyl)pyridine; 2 -bromo-5-(4-fluorophenyly..4-(4..{methylsulfonyl)phenyl..6 (trifluoromethyl)pyridine; 4 2 3 -chloro-4-methoxyphenyl)-4,5-difluorophenyl)benzenesulfonamjide; l-( 4 -fluorophenyly..2-.(4(methylsulfonyl)phenyl)benzen; 114 5-difluoromethyl-4-(4-(methylsulfonyl)phenyl)-3-phenylisoxazole; 4-(3-ethyl-5-phenylisoxazol-4-yl)benzenesulfonamide; 4-(5-difluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 4-(5-hydroxymethyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 4-(5-methyl-3-phenylisoxazol-4-yL)benzenesulfonamide; 1-(2-(4-fluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-fluoro-2-methylphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-chlorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(2,4-dichlorophenylcyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-trifluoromethylphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-methylthiophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-fluorophenyl)-4,4-dimethylcyclopenten-1-yl)-4- (methylsulfonyl)benzene; 4-(2-(4-fluorophenyl)-4,4-dimethylcyclopenten- 1-yl)benzenesulfonaniide; 1-(2-(4-chlorophenyl)-4,4-dimethylcyclopenten-1-yl)-4- (methylsulfonyl)benzene; 4-(2-(4-chlorophenyl)-4,4-dimethylcyclopenten-1-yl)benzenesulfonamide; 4-2(-lorpey*ycoetn1**bneesloaie 4-(2-(4-lorophenyl)cyclopenten-1-yl)benzenesulfonamide; 20 1-(2-(4-methoxyphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(2,3-difluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 4-(2(3fluoro4methoxypheny)cyclopenten1y)benzenesulfonapmjde; 1-(2-(3-chloro-4-methoxyphenyl)cyclopenten- l-yl)-4- (methylsulfonyl)benzene; 4-(2-(3-chloro-4-fluorophenyl)cyclopenten- 1-yl)benzenesulfonamide; 4-(2-(2-methylpyridin-5-yl)cyclopenten-1-y1)benzenesulfonanmjde; ethyl 2 4 -(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)-2- benzyl-acetate; 2 -(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)acetic acid; 2 -(tert-butyl)-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazole; 4 4 -fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-phenyloxazole; 115 4 4 -fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)oxazole; and 4 3 -fluoro-4-methoxyphenyl)-2-trifluoromethyl-4. oxazolyl)benzenesulfonaniide; or a pharmaceutically acceptable salt thereof. 21. The use of a NK-1 receptor antagonist for the manufacture of a medicament for the combined use with a selective cyclooxygenase-2 inhibitor for preventing or reducing the risk of developing an inflammatory disorder, for halting or slowing the progression of an inflammatory disorder, or for preventing or reducing the risk of occurrence or recurrence of an inflammatory disorder, wherein said selective COX-2 inhibitor is selected from the group consisting of: 3-hnl4(-(ehlufny hnl--(H-uaoe 3 3 4 -difluorophenyl)-4-(4(methylsulfony)phenyl)2.(5H)-furanone; 4 -(4-(methylsulfonyl)phenyl)3(3fluorophenyl)5H-fran-2. one; 4 (4(methylsulfonyl)phenyl)3.(2propoxy)5H.furan2one; 20 2 3 ,5-difluorophenyl)3(4(methylsulfonyl)phenyl)2cyclopentenlone; 9 (S)-5-ethyl-5-methyl-4-(4(methylsulfonyl)phenyl)3.(2propoxy)-5H- 2~ furan-2-one; 5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)3(3,4-dijfluorophenyl)5H. furan-2-one; 3 2 -thiazolyl)methoxy)-4-(4-(methylsulfonyl)phenyl)..,s.dimethyls5H furan-2-one; 3 -propyloxy- 4 4 -(methylsulfonyl)phenyl)-,5-dimethyl.sHfran2-one; 3 -(l-cyclopropylethoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl)5H- furan-2-one; sodium 2 4 -chlorophenyl)-3-(4(methylsulfonyl)phenyl)4ox-2- pentenoate; 116 0 0 00 0* 00 0 0000 0000 3 -(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H. furan-2-one; 3 -(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-2,5-. dihydrofuran-2-ol; 3 -isopropoxy-5,5-dimethy-4-(4-(methylsulfony1)phenyl).25-ihydroffiran. 2-ol; 5,S-dimethyl-3-(3-fluoropheny)-2-hydroxy-4-(4(methysufony)pheny). 5-chloro-3-(4-(methylsulfonyl)phenyl)-2-(3-pyridinyl)pyridine; 10 4 -(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonanmjde; 5-(4-fluorophenyl)-1- [4-(methylsulfonyl)phenyl] -3- (trifluoromethyl)pyrazole; 4-(4-fluorophenyl)-5- [4-(methylsulfonyl)phenyll -1-phenyl-3- (trifluoromethyl)pyrazole; 4 4 -chlorophenyl)-3-(4-methoxypheny)-lH-pyrazol-1.. yl)benzenesulfonamide; 4 -(3,5-bis(4-methylphenyl)- 1H-pyrazol-1-yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-phenyl- lH-pyrazol-1-yl)benzenesulfonamide; 4 3 ,S-bis(4-methoxyphenyl)-1H-pyrazol- 1-yl)benzenesulfonamide; 20 4 4 -chlorophenyl)-3-(4-methylphenyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4 4 -chlorophenyl)-3-(4-nitrophenyl)-1H-pyrazol-l-. yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-(5-chloro-2-thienyl)-1H-pyrazol- 1- yl)benzenesulfonamide; 4-(4-chloro-3,5-diphenyl- lH-pyrazol-1-yl)benzenesulfonamide; 4 4 -chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-l- yl)benzenesulfonamide; 4 -(5-phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide; 4 -(5-(4-fluorophenyl)- 3 -(trifluoromethyl)-1H-pyrazol-1- yl)benzenesulfonamide; 117 4 4 -methoxyphenyl)-3-(trifluoromethyl)-lH-pyrazoll- yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-(difluoromethyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4 4 -methylphenyl)-3-(trifluoromethyl)-lH.pyrazol.1. yl)benzenesulfonamide; 4 4 -chloro-5-(4-chloropheny1)-3-(trifluoromethyl)1H-pyrazol-l-. yl)benzenesulfonamide; 4 3 -(difluoromethyl)-5-(4-methylphenyl)-H-pyrazol-l-. yl)benzenesulfonamide; 4 3 -(difluoromethy)-5-(4-methoxypheny)-lHpyrazo..1.. yl)benzenesulfonamide; 4 -(3-cyano-5-(4-fluorophenyl)- lH-pyrazol-1-yl)benzenesulfonamide; 4 3 -(difluoromethy1)-5-(3-fluoro4-methoxypheny)1lH-pyazol-l-1 yl)benzenesulfonamide; 4 3 -fluoro-4-methoxyphenyl)-3-(trifluoromethyl). H-pyrazol-1- yl)benzenesulfonamide; 4 4 -chloro-5-pheny-lH-pyrazo1-y1)benzenesulfonamide; 20 4 4 -chlorophenyl)-3-(hydroxyphenyl)1Hpyrazol.1. yl)benzenesulfonamide; a, a. 4 4 -(N,N-dimethylamino)phenyl)-3-(trifluoromethyl).1H-pyrazol1.. yl)benzenesulfonamide; 4 -fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.4]hept-5-ene; 4 6 4 -fluorophenyl)spiro 2 4 6 4 -fluorophenyl)-7-(4-(methylsulfonyl)phenyl)spiro oct-6-ene; 5-3clr--ehxpey)6(4(ehlufnlpey pr[2.4]hept- 4 6 3 -chloro-4-methoxyphenyl)spiro [2 .4lhept-5-en-5- yl)benzenesulfonamide; 118 5-(3 ,5-dichloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)- Spiro 3 -chloro-4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro ene; 4 -(6-(3,4-dicfflorophenyl)spiro 2-(3-chloro-4-fluorophenyl)-4-(4-fluorophenyl)-5-(4- methylsulfonylphenyl)thiazole; 2 2 -chlorophenyl)-4-(4-fluorophenyl).5-.(4..methylsulfonylphenyl)thiazole; 5-(4-fluorophenyl)-4-(4-methylsulfonylphenyl)-2-methylthiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-(2-thienyl)thiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-benzylanminothiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-( 1-propylamino)thiazole; 2 -((3,5-dichlorophenoxy)methyl)-4-(4-fluorophenyl)-5-(4- (methylsulfonyl)phenyl)thiazole; 4 -fluorophenyl)-4-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 1-methylsulfonyl-4-( 1, 1-dimethyl-4-(4-fluorophenyl)cyclopenta-2,4-dien-3- yl)benzene; 4-(4-(4-fluorophenyl)- 1, 1-dimethylcyclopenta-2,4-dien-3- *ee. 20 yl)benzenesulfonamide; S-( 4 -fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.41 hepta-4,6-diene; 4 6 -(4-fluorophenyl)spiro 2 .4]hepta-4,6-dien-5-yl)benzenesulfonamide; 6 4 -fluorophenyl)-2-methoxy-5-(4-(methylsulfonyl)phenyl).pyridine3- carbonitrile; 2 -bromo-6-( 4 -fluorophenyl)-5-(4-(methylsulfonyl)phenyl).pyidine.3 carbonitrile; 6 4 -fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-phenyl-pyridine3- carbonitrile; 4 2 4 -methylpyridin-2-yl)-4-(trifluoromethyl)-H-imidazol.1. yl)benzenesulfonamide; 119 4-(2-(5-methylpyridin-3-yl)-4-(trifluoromethyl)-1H-imidazol-l- yl)benzenesulfonamide; 4-(2-(2-methylpyridin-3-yl)-4-(trifluoromethyl)- 1H-imidazol- 1- yl)benzenesulfonamide; 3-(1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H-imidazol-2- yl)benzenesulfonamide; 2-(l-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H-imidazol-2- yl)pyridine; 2-methyl-4-(1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)- 1H-imidazol- 2-yl)pyridine; e~g. 2-methyl-6-(l-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H-imidazol- 2-yl)pyridine; 4-(2-(6-methylpyridin-3-y1)-4-(trifluoromethy1)-lH-imidazol-1- yl)benzenesulfonamide; 2-(3,4-difluorophenyl)-1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H- imidazole; 4-(2-(4-methylphenyl)-4-(trifluoromethyl)-1H-imidazol-l- yl)benzenesulfonamide; 2-(4-chlorophenyl)-1-(4-(methylsulfonyl)phenyl)-4-methyl-1H-imidazole; 2-(4-chlorophenyl)-l-(4-(methylsulfonyl)phenyl)-4-phenyl-1H-imidazole; 2-(4-chlorophenyl)-4-(4-fluorophenyl)- 1-(4-(methylsulfonyl)pheny1)-1H- imidazole; 2-(3-fluoro-4-methoxyphenyl)-l-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)-1H-imidazole; l-(4-(methylsulfonyl)phenyl)-2-phenyl-4-trifluoromethyl-lH-imidazole; 2 -(4-methylphenyl)-1-(4-(methylsulfonyl)phenyl)-4-trifluoromethyl-1H- imidazole; 4-(2-(3-chloro-4-methylphenyl)-4-(trifluoromethyl)- 1H-imidazol- 1- yl)benzenesulfonamide; 2 -(3-fluoro-5-methylphenyl)-1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)- 1H-imidazole; 120 4 2 3 -fluoro-5-methylphenyl)-4-(trifluoromethyl).lH-imsdazol-l- yl)benzenesulfonamide; 2 3 -methylphenyl)-1-(4-(methylsulfonyl)phenyl)4.(trifluoromethyl). H- imidazole; 4 2 -(3-methylphenyl)-4-(trifluoromethy)-H-imjdazo...1 yl)benzenesulfonamide; 1-( 4 -(methylsulfony)phenyl)-2-(3-choropheny)4(trifluoromethyl).1H- imidazole; 4 2 3 -chlorophenyl)-4-(trifluoromethy)-lH-imidazol-l- yl)benzenesulfonamide; 4 2 -phenyl- 4 -(trifluoromethy)-1H-imdazo1..y1)benzenesulfonamide; 4 2 4 -methoxy-3-chlorophenyl)-4-(trifluoromethyl)1H..jmjdazol. yl)benzenesulfonamide; -allyl- 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)5.(trifluoromethy)- 1H-pyrazole; 4 -(l-ethyl- 4 -(4-fluoropheny1)-5-(trifluoromethyl)1lH..pyazo13. yl)benzenesulfonamide; a a N-phenyl-(4-(4-fluorophenyl)3(4(methysufony)pheny)5- 0a 2 et( 4 4 -fluorophenyl)-3-(4-(methylsulfonyl) nyl)2pyltlrmeHyl lpyrazol-1yceae a 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)..(2.phenylethyl)15. 2 tiloehlpyrazole; 1el 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(t(2.phenylethyl)..5. (tioomylprazole; l-etl 4 lH-pyazole; flohey) 4 4 -(methylsulfonyl)phenyl)...2tiohny)2(trifluoromethyl)..IH. imidazole; 121 4 -fluorophenyl)-2-methoxy-4-(4-(methylsulfonyl)phenyl)-6- (trifluoromethyl)pyridine; 2-ethoxy-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-6. (trifluoromethyl)pyridine; 5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(2-propynyloxy)-6- (trifluoromethyl)pyridine; 2-bromo-5-(4-fluoropheny)-4-(4-(methysufony)pheny)-6- (trifluoromethyl)pyridine; 4 2 -(3-chloro-4-methoxyphenyl)-4,5-difluorophenyl)benzenesulfonamide; l-( 4 -fluorophenyl)-2-(4-(methylsulfonyl)phenyl)benzene; 5-difluoromethyl-4-(4-(methylsulfonyl)phenyl)-3-phenylisoxazole; 4 -(8-ethyl-5-phenylisoxazol-4-yl)benzenesulfonamide; 4 -(5-difluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 4-5hdoxmty*-peyioxzl4y*bneeuloa*e 4 -(5-hyxmethyl-3-phenylisoxazol-4-yl)benzenesulfonamide; -(2-metyl-3phenylisycoazo--yl)enzeneulnamidle; zn l-( 2 -(4-fluoro-2myphenyl)cyclopenten- 1-yl)-4-(methylsulfonyl)benzene; 1-( 2 4 -lorop2-eyh~yclpheny-)cyc )-openteny).4.(metyl~bunznyenzne 0*-iclrpeylccoetn--l--mehlufny~enee l-( 2 -(4-chiloromyphenyl)cyclopenten- 1-yl)-4-(methylsulfonyl)benzene; l-( 2 24 -dichlorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 2 -(4-trfluoromyphenyl)dmtcyclopenten- 1-yl)-4-ehsufnlbzn; l{(mtytipey~ylpne-1y)4(methylsulfonyl)benzene; 25 2 -(4-lorophenyl)-4,4-dimethylcyclopenten- l-yl)-4- (methylsulfonyl)benzene; 4 2 4 -lorophenyl)-4,4-dimethylcyclopenten-1-yl)benzenesulfonanide; 4-(2-(4-lorophenyl)-44dtycyclopenten- 1-yl)benzenesulfonamide; 4-(2-(4-lorophenyl)cyclopenten- 1-yl)benzenesulfonamide; 4 2 4 -cehloophenyl)cyclopenten-1-yl)enzeesulfonide zn 1-(2--metoyphenyl)cyclopenten- l-yl)-4-(methylsulfonyl)benzene; 0-_ 122 4 2 3 -fluoro-4-methoxyphenyl)cyclopenten-1 -yl)benzenesulfonamjde. l-( 2 3 -chloro-4-methoxyphenyl)cyclopenten-l-yl)-4- (methylsulfonyl)benzene; 4-2(-hoo4furpey~yloetn1y~eznsloaie 4 2 2 -methylpyridin-5syl)cyclopenten-. -yl)benzenesulfonamide; ethyl 2 4 4 -fluorophenyl)5(4(methysulfonyl)phenyl)oxazol 2 yl)- 2 benzyl-acetate; 2 4 4 fluorophenyl)5.(4(methylsufo~hnyl)heny1oxazol)cti acid; 4 4 fluorophenyl)5-(4(4..(methfoylulfnynyl)peyl2phe 4 4 fluorophenyl)2mehy5(4(m ethluoylulfonyl)henle;an 4-5(3fuoo4-ehoyhey) andlormthl4 oxazolyl)benzenesulfonamide; :9 or a pharmaceutically acceptable salt thereof. 22. The use of a selective cyclooxygeriase-2 inhibitor for the preparation of a medicament for the combined use with a NK-1 receptor antagonist for preventing or reducing the risk of developing an inflammatory disorder, .see*: 20 for halting or slowing the progression of an inflammatory disorder, or for preventing or reducing the risk of occurrence or recurrence of an inflammatory disorder, wherein said selective COX-2 inhibitor is selected from the group consisting of: 3-(3,4dfurpey)4(-mtysufnlpey)2(H-uaoe one; 2-(3 ,5-dfurpey)3(-mtyslonlpey)2ccoetnloe 123 5(S)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-SH- furan-2-one; 5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(3,4..difluorophenyl)-5H. furan-2-one; 3 2 -thiazoly1)methoxy)-4-(4-(methylsulfonyl)phenyl)-5,5-dimethy..5H. furan-2-one; 3 -propyloxy-4-(4-(methylsulfonyl)phenyl).5,5-dimethyl..SH.furan-2-one; 3 -(l-cyclopropylethoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl)-5H. furan-2-one; sodium 2 4 -chlorophenyl)-3-(4-(methylsulfonyl)phenyl)-4-oxo-2- pentenoate; 3 -(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H- furan-2-one; 3 -(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-2,5. dihydrofuran-2-ol; 3 -isopropoxy-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl).2,5..dihydrofuran. 2-ol; 5,5-dimethyl-3-(3-fluorophenyl)-2-hydroxy-4-(4-(methylsulfonyl)phenyl). 5-chloro-3-( 4 -(methylsulfony1)phenyl)-2(3pyridinyl)pyridine; 4 -(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; 5-(4-fluorophenyl)-1- [4-(methylsulfonyl)phenyll -3- (trifluoromethyl)pyrazole; 4-(4-fluorophenyl)-5-[14-(methylsulfonyl)phenyl] -phenyl-3- (trifluoromethyl)pyrazole; 4 4 -chlorophenyl)-3-(4-methoxyphenyl).lHprazol.1 ylbenzenesulfonamide; 4-(3 ,5-bis(4-methylphenyl)- 1H-pyrazol- 1-yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-phenyl- lH-pyrazol-1-yl)benzenesulfonamide; 4-(3 ,5-bis(4-methoxyphenyl)- lH-pyrazol-1-y1)benzenesulfonamide; 124 4 -(5-(4-chlorophenyl)-3-(4-methylphenyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-(4-nitrophenyl)- 1H-pyrazol- 1- yl)benzenesulfonamide; 4 4 -chlorophenyl)-3-(5-chloro-2-thienyl)-lH-pyrazol-1- yl)benzenesulfonamide; 4 4 -chloro-3,5-dipheny-lH-pyrazo-1-y)benzenesufonamAde; 4 4 -chlorophenyl)-3-(trifluoromethyl)-lH-pyrazol-l- yl)benzenesulfonamide; 4 -(5-phenyl)- 3 -(trifluoromethyl)-lH-pyrazol-1-yl)benzenesulfonamiae; 4 4 -fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol- 1- S yl)benzenesulfonamide; 4 4 -methoyphenyl)-3-(trifluoromethyl)- H-pyrazol-- yl)benzenesulfonamide; 0* 15 4 4 -chlorophenyl)-3-(rifluoromethyl)-H-pyrazol- yl)benzenesulfonamide; 4 -(3-dfurmty)5-( 4 -methylphenyl)-3-tilooehl1H-pyrazol-1- 6 yl)benzenesulfonamide; Se.' 4 -(3-chiloromet4-hlrohey1)-3rfluoromthpety)-Hpyrazol-l- 4 -(5-3-di o4-ehxphnl--(trifmehy-5(4mthopen1) H-ylHprazol- *S 30 yl)benzenesulfonamide; 3- R7- 4 -3-iloromhl-5-phenyl- 1H-pyrazol-1-yl)benzenesulfonamide; 013 F 1- 125 4-(5-(4-chlorophenyl)-3-(hydroxyphenyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4 -(5-(4-(N,N-dimethylamino)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1- yl)benzenesulfonamide; 5-(4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro 4-(6-(4-fluorophenyl)spiro [2.4]hept-5-en-5-yl)benzenesulfonamide; 6-(4-fluorophenyl)-7-(4-(methylsulfonyl)phenyl)spiro oct-6-ene; 5-(3-chloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.41 hept- 4-(6-(3-chloro-4-methoxyphenyl)spiro [2.4]hept-5-en-5- yl)benzenesulfonamide; 0 5-(3,5-dichloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)- 0 0 0. Spiro [2.4]hept-5-ene; 5-(3-chloro-4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro ene; 4-(6-(3,4-dichlorophenyl)spiro 2 -(3-chloro-4-fluorophenyl)-4-(4-fluorophenyl)-5-(4- methylsulfonylphenyl)thiazole; :00.0 2 2 -chlorophenyl)-4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)thiazole; 00.0 20 5-( 4 -fluorophenyl)-4-(4-methylsulfonylphenyl)-2-methylthiazole; .o 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 0 0 oo...o 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-(2-thienyl)thiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-benzylaminothiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-(1-propylamino)thiazole; 2 -((3,5-dichlorophenoxy)methyl)-4-(4-fluorophenyl)-5-(4- (methylsulfonyl)phenyl)thiazole; 4 -fluorophenyl)-4-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 1-methylsulfonyl-4-(1, 1-dimethyl-4-(4-fluorophenyl)cyclopenta-2,4-dien-3- yl)benzene; 4-(4-(4-fluorophenyl)-1, 1-dimethylcyclopenta-2,4-dien-3- Syl)benzenesulfonamide; 126 4 -fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro hepta-4,6-diene; 4 -(6-(4-fluorophenyl)spiro[1 2 4 hepta-4,6-dien-5-yl)benzenesulfonamide; 6 4 -fluorophenyl)-2-methoxy-5-(4-(methylsulfonyl)phenyl)pyridine3- carbonitrile; 2 -bromo-6-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)..pyicine-3 carbonitrile; 6 4 -fluoropheny)-5-(4-(methylsulfonyl)phenyl)-2-pheny1..pyrdine.3 carbonitrile; 4 2 -(4-methylpyridin-2-yl)-4-(trifluoromethyl)-lHimidazol-l. yl)benzenesulfonamide; 4 2 -(5-methylpyridin-3-yl)-4-(trifluoromethyl)..lHimidazol-l-. yl)benzenesulfonamide; *:eo 4 2 2 -methylpyridin-3-yl)-4-(trifluoromethyl).. H-imidazol- 1- I. yl)benzenesulfonamide; 0 15 3 4 -(methylsulfonyl)phenyl)-4-(trifluoromethyl) 1H-imidazol-2- yl)benzenesulfonamide; 2 4 -(methylsulfonyl)phenyl)-4-(trifluoromethyl)..lHjijdazol.2 yl)pyridine; o o 2 -methyl-4-(1-(4-(methylsufony)pheny)4(trifluoromethyl).1Hjimdaz1.. *oo 20 2-yl)pyridine;
250. 2-(3 4 -lurphyl-(4-(methylsulfonyl)phenyl)4(trifluoromethyl) 1H...daol o -yim ide; 0 oc 4 2 -(6-methylpheinyl)-4-(trifluoromethyl)-H-imidazol-l- yl)benzenesulfonamide; 2-(4-chlorophenyl)- l-( 4 -(methylsulfony)pheny)-4-methy...H-imidazole; 2-4clrpey)l(-mtyslonlpey)4pey-Hiiaoe 127 2-(4-chlorophenyl)-4-(4-fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-1H- imidazole; 2-(3-fluoro-4-methoxyphenyl)- 1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)- iR-imidazole; 1-(4-(methylsulfonyl)phenyl)-2-phenyl-4-trifluoromethylblH-imidazole; 2 -(4-methylphenyl)-1-(4-(methylsulfonyl)phenyl)-4-trifluoromethyl.1H imidazole; 4 -(2-(3-chloro-4-methylphenyl)-4-(trifluoromethyl)-1H-imidazol-l- yl)benzenesulfonamide; 2 -(3-fluoro-5-methylphenyl)-1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)- 1H-imidazole; 4-(2-(3-fluoro-5-methylphenyl)-4-(trifluoromethyl)- 1H-imidazol- 1- yl)benzenesulfonamide; 2-(3-methylphenyl)- 1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)- 1H- imidazole; 4-(2-(3-methylphenyl)-4-(trifluoromethyl)-1H-imidazol-1- yl)benzenesulfonamide; l-(4-(methylsulfonyl)phenyl)-2-(3-chlorophenyl)-4-(trifluoromethyl)-lH- imidazole; 20 4 2 -(3-chlorophenyl)-4-(trifluoromethyl)-1H-i-idazol-1- yl4benzenesulfonamide; 4 -(2-phenyl-4-(trifluoromethyl)-1H-imidazol-1-yl)benzenesulfonamide; 4-(2-(4-methoxy-3-chlorophenyl)-4-(trifluoromethyl)- 1H-imidazol-1- yl)benzenesulfonamide; 1-allyl-4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl)- 1H-pyrazole; 1-ethyl-4-(4-fluorophenyl)-5-(trifluoromethyl)- 1H-pyrazol-3- yl)benzenesulfonamide; N-phenyl-(4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5- (trifluoromethyl)-1H-pyrazol-1-yl)acetamide; 128 ethyl (4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl). lH-pyrazol-1-yl)acetate; 4 -(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-1-(2-phenylethyl)1H- pyrazole; 4 -(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)- 1-(2-phenylethyl)-5- (trifluoromethyl)pyrazole; l-ethyl-4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl).5.(trifluoromethyl). 1H-pyrazole; 4 -fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(trifluoromethyl)1lH imidazole; 4 -(4-(methylsulfonyl)phenyl)-5-(2-thiophenyl)-2-(trifluoromethyl)lH- imidazole; 5-(4-fluorophenyl)-2-methoxy-4-(4-(methylsulfonyl)phenyl)6. (trifluoromethyl)pyridine; 15 2 -ethoxy-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)6. (trifluoromethyl)pyridine; 4 -fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(2-propynyloxy).6 (trifluoromethyl)pyridine; 2 -bromo-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)6- 20 (trifluoromethyl)pyridine; 4 2 3 -chloro- 4 l-( 4 -fluorophenyl)-2-(4-(methylsulfonyl)phenyl)benzene; 0. 90: -difluoromethyl-4-(4-(methylsulfonyl)phenyl).3-phenylisoxazole; 4 3 -ethyl-5-phenylisoxazol-4-ylenzenesulfonamide; 4-5hdoyehl3peyioxzl4y~eznsloaie 4 -(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide; l-( 2 -(4-fluorophenyl)cyclopenten- l-yl)-4-(methylsulfonyl)benzene; l-( 2 4 -fluoro-2-methylphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; l1-( 2 -(4-chlorophenyl)cyclopenten- l-yl)- 4 -(methylsulfonyl)benzene; l-( 2 2 ,4-dichlorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 129 l-( 2 4 -trifluoromethylphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; l-( 2 4 -methylthiophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; l-( 2 4 -fluorophenyl)-4,4-dimethylcyclopenten-1-yl)-4- (methylsulfonyl)benzene; 4 2 4 -fluorophenyl)-4,4-dimethylcycopenten.1yl)benzenesulfonamide; l-( 2 4 -chlorophenyl)-4,4-dimethylcyclopenten- l-yl)- 4 (methylsulfonyl)benzene; 4 2 -(4-chlorophenyl)-4,4-diniethylcyclopenten- 1-yl)benzenesulfonamide; 4 2 4 -fluorophenyl)cyclopenten-1-yl)benzenesulfonamide; 4 2 4 -chlorophenyl)cyclopenten-1-yl)benzenesulfonamide; l-( 2 4 -methoxyphenyl)cyclopenten-1-yl).4.(methylsulfonyl)benzene; l-( 2 2 3 -difluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 4 2 3 -fluoro- 4 -methoxyphenyl)cyclopenten-1-y1)benzenesulfonamide; l-( 2 3 -chloro-4-methoxyphenyl)cyclopenten-1-yl)-4- 15 (methylsulfonyl)benzene; 4 2 3 -chloro-4-fluorophenyl)cyclopenten..1.yl)benzenesulfonamide; 4 2 2 -methylpyridin-5-yl)cyclopenten-1-yl)benzenesulfonanmjde; ethyl 2 4 4 -fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol2yl)2. benzyl-acetate; 2 4 4 -fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol2yl)acetic acid; 2 -(tert-butyl)-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazole; 4 4 -fluorophenyl)-5-(4-(methylsulfonylphenyl)-2-phenyloxazole; 4 4 -fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)oxazole; and 4 3 -fluoro-4-methoxyphenyl)-2-trifluoromethyl-4- oxazolyl)benzenesulfonamide; or a pharmaceutically acceptable salt thereof. 23. A use, composition, product or method according to any one of the preceding claims wherein the inflammatory disorder is selected from 130 rheumatoid arthritis, degenerative joint diseases, osteoarthritis, bursitis, tendinitis, ankylosing spondylitis, gout and synovitis. 24. Use of a selective COX-2 inhibitor and a NK-1 receptor antagonist for the manufacture of a medicament for the treatment or prevention of inflammatory disorders, wherein said selective COX-2 inhibitor is selected from the group consisting of: 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone; 3 4 -difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone; 5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3-(3-fluorophenyl).SHfuran.2 one; 4 4 -(methylsulfonyl)phenyl)-3-(2-propoxy).SH-furan-2.one; -chloro-3-(4-(methylsulfonyl)phenyl)-2-(2-methybspyridinyl)pyr.idine; 2-(3,5-d1ifuorophenyl)- 3 -(4-(methysulfonyl)phenyl)2cyclopenten-1-one; 15 5(S)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)3(2propoy)-5H- furan-2-one; 5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl).3.(3,4..difluorophenyl).5H- furan-2-one; 3 2 -thiazolyl)methoxy)-4-(4-(methylsulfonyl)phenyl)5,Sdimethyl-5H- furan-2-one; 3 -propyloxy- 4 -(4-(methylsulfonyl)phenyl)-,5.dimethyl..H.furan-2..one; 1-cyclopropyettioxy)-5,5-dimethyl-4-(4methylsulfonyl)phenyl).5H. furan-2-one; sodium 2 4 -chlorophenyl)-3-(4-(methylsulfonyl)phenyl)4.oxo.2. pentenoate; 3 -(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl).5H- furan-2-one; 3 -(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl).2,s.. dihydrofuran-2-ol; .3-isopropoxy-5,5-dimethyl- 4 -(4-(methylsulfonyl)phenyl)-2,5-dihydroffiran. 2-ol; 131 5,5-dimethyl-3-(3-fluorophenyl)-2-hydroxy-4-(4-(methylsulfonyl)phenyl)- 5-chloro-3-(4-(methylsulfonyl)phenyl)-2-(3-pyridinyl)pyridine; 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; 5-(4-fluorophenyl)-1-[14-(methylsulfonyl)phenyl] -3- (trifluoromethyl)pyrazole; 4-(4-fluorophenyl)-5- [4-(methylsulfonyl)phenyll -1-phenyl-3- (trifluoromethyl)pyrazole; 4-(5-(4-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4-(3,5-bis(4-methylphenyl)-1H-pyrazol- 1-yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-phenyl-1H-pyrazol- 1-yl)benzenesulfonamide; 4 -(3,5-bis(4-methoxyphenyl)-1H-pyrazol-1-yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(4-methylphenyl)-1H-pyrazol- 1- ylbbenzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-(4-nitrophenyl)-1H-pyrazol- 1- yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-(5-chloro-2-thienyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4 4 -chloro-3,5-diphenyl-lH-pyrazol-1-yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1- yl)benzenesulfonamide; 4 -(5-phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonarnide; 4-(5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol- 1- 4-(5-(4-mhophenyl)-3-(ifluoromethyl)-H-pyrazol- yl)benzenesulfonamide; 4-(5-(4-cehlphenyl)-3-(difluoromethyl)- 1H-pyrazol-- FAyl)benzenesulfonamide; -132- 4 4 -chloro-5-(4-chlorophenyl)-3-(trifluoromethyl)-lH-pyrazol- 1- yl)benzenesulfonamide; 4 -(3-(difluoromethyl)-5-(4-methylphenyl)-1H-pyrazol-l- yl)benzenesulfonamide; 4 -(3-(difluoromethyl)-5-phenyl-1H-pyrazol-1-yl)benzenesulfonamide; 4 -(3-(difluoromethyl)-5-(4-methoxyphenyl)-1H-pyrazol-l- yl)benzenesulfonamide; 4-(3-cyano-5-(4-fluorophenyl)-1H-pyrazol- 1-yl)benzenesulfonamide; 4 3 -(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-lH-pyrazol-l-. yl)benzenesulfonamide; 4 -(5-(3-fluoro-4-methoxyphenyl)-3-(trifluoromethyl)-lH-pyrazol-l- yl)benzenesulfonamide; 4-(4-chloro-5-phenyl- 1H-pyrazol-1-yl)benzenesulfonamide; 4 -(5-(4-cffiorophenyl)-3-(hydroxyphenyl)- 1H-pyrazol- 1- 1 5 yl)benzenesulfonamide; 4 4 -(N,N-dimethylamino)phenyl)-3-(trifluoromethyl)-lH-pyrazol yl)benzenesulfonamide; 4 -fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro 4 6 -(4-fluorophenyl)spiro [2.4]hept-5-en-5-yl)benzenesulfonamide; 6 4 -fluorophenyl)-7-(4-(methylsulfonyl)phenyl)spiro oct-6-ene; S-( 3 -chloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)spiro hept- 4 -(6-(3-chloro-4-methoxyphenyl)spiro [2.4]hept-5-en-5- yl)benzenesulfonamide; 5-(3,5-dichloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl). Spiro [2.4]hept-5-ene; 3 -chloro-4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro ene; ,4-dichlorophenyl)spiro 2-(3-chloro-4-fluorophenyl)-4-(4-fluorophenyl)-5-(4- ,~~thysu~onypheny)thiazole; 133 2 2 -chlorophenyl)-4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)thiazole; 5-(4-fluorophenyl)-4-(4-methylsulfonylphenyl)-2-methylthiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 4 -(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-2-(2-thienyl)thiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-benzylaminothiazole; 4 -(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-2-( 1-propylamino)thiazole; 2-((3,5-dichlorophenoxy)methyl)-4-(4-fluorophenyl)-5-(4- (methylsulfonyl)phenyl)thiazole; 4 -fluorophenyl)-4-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 1-methylsulfonyl-4-(1, 1-dimethyl-4-(4-fluorophenyl)cyclopenta-2,4-dien-3- yl)benzene; 4-(4-(4-fluorophenyl)-1, 1-dimethylcyclopenta-2,4-dien-3- yl)benzenesulfonamide; 5-( 4 -fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.4]hepta-4,6-diene; 15 4-(6-(4-fluorophenyl)spiro hepta-4,6-dien-5-yl)benzenesulfonamide; 6 4 -fluorophenyl)-2-methoxy-5-(4-(methylsulfonyl)phenyl)-pyricdine-3- carbonitrile; 2 -bromo-6-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl).pyridine-3. carbonitrile; 6 4 -fluorophenyl)-5-(4-(methyllsulfonyl)phenyl)-2-phenyl-pyridine.3 carbonitrile; 4 2 -(4-methylpyridin-2-yl)-4-(trifluoromethyl)-J.H-imidazo1-1- yl)benzenesulfonamide; 4 2 -(5-methylpyridin-3-y1)-4-(trifluoromethyl)-lH-imdazol-l- yl)benzenesulfonamide; 4 2 2 -methylpyridin-3-yl)-4-(trifluoromethyl) 1H-imidazol-1- yl)benzenesulfonamide; l-( 4 -(methylsulfonyl)phenyl)-4-(trifluoromethyl H-imidazol-2- yl)benzenesulfonamide; l-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyly H-imidazol-2- Syl)pyridine; 134 2-methyl-4-( l-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)-1H-imidazol- 2-yl)pyridine; 2 -methyl-6-(1-(4-(methylsulfonyl)pheny1)-4-(trifluoromethyl)...Hjimidazol1 2-yl)pyridine; 4 2 -(6-methylpyridin-3-yl)-4-(trifluoromethyl)-lH-imidazol1.. yl)benzenesulfonam-ide; 2-(3,4-difluorophenyl)- 1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)- 1H- inidazole; 4 4 -methylphenyl)-4-(trifluoromethyl)-1H-imidazol-l- yl)benzenesulfonamide; 2 4 -chlorophenyl)-1-(4-(methylsulfonyl)phenyl)-4-methyl- iR-imidazole; 2-(4-chlorophenyl)- 1-(4-(methylsulfonyl)phenyl)-4-phenyl-1H-imidazole; 2 4 -chlorophenyl)-4-(4-fluorophenyl)--(4-(methylsulfonyl)phenyl)lH- imidazole; 15 2 3 -fluoro-4-methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)-1H-imidazole; l-( 4 -(methylsulfonyl)phenyl)-2-phenyl-4-trifluoromethyl-lH-iniidazole; 2 4 -methylphenyl)-1-(4-(methylsulfonyl)phenyl)-4-trifluoromethyl4lH imidazole; 20 4 2 3 -chloro-4-methylphenyl)-4-(trifluoromethyl)-1H-imidazol- 1- yl)benzenesulfonamide; 2 -(3-fluoro-5-methylphenyl)-1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)- 1H-imidazole; 4 2 -(3-fluoro-5-methylphenyl)-4-(trifluoromethyl)-1H-imidazol- 1- yl)benzenesulfonamide; 2-(3-methylphenyl)- 1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl)- 1H- imidazole; 4 2 3 -methylphenyl)-4.(trifluoromethyl)- H-imidazol- 1- yl)benzenesulfonamide; l-( 4 -(methylsufony)pheny)-2-(3-chlorophenyl)-4-(trifluoromethyl) 1H- imidazole; 135 4 2 -(3-chlorophenyl)-4-(trifluoromethyl)-lH-imidazol-1- yl)benzenesulfonamide; 4-(2-phenyl-4-(trifluoromethyl)- lH-imidazo-1-y1)benzenesulfonaniide; 4 2 -(4-methoxy-3-chloropheny)-4-(trifluoromethy)1H-imdazol-l1. yl)benzenesulfonamide; l-allyl- 4 -(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl).5.(trifluoromethyl)- 1H-pyrazole; 4 -(l-ethyl-4-(4-fluorophenyl)-5-(trifluoromethyl)1Hpyrazol3. yl)benzenesulfonamide; N-phenyl-( 4 -(4-fluiorophenyl)-3-(4-(methylsulfonyl)phenyl)s.. (trifluoromethyl)-1H-pyrazol-1-yl)acetamide; a ethyl 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-(trifluoromethyl)- lH-pyrazol-1-yl)acetate; a 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)..1.(2-phenylethyl)..H- pyrazole; 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl).1.(2-.phenylethyl)-5 (trifluoromethyl)pyrazole; l-ethyl-4-( 4 -fluorophenyl)-3(4(methylsulfonyl)phenyl)-5.(trifluoromethyl). 1H-Dvrazole; 5-( 4 -fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(trifluoromethyl)-lH- a imidazole; 4 4 -(methylsulfonyl)phenyl)-5-(2-thiophenyl)2(trifluoromethyl)1lH imidazole; 4 -fluorophenyl)-2-methoxy-4-(4-(methylsulfonyl)phenyl).6. (trifluoromethyl)pyridine; 2 -ethoxy-5-(4-fluorophenyl)4.(4-.(methylsutfonyl)phenyl..6 (trifluoromethyl)pyridine; 4 -fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(2-propynyoxy..6- (trifluoromethyl)pyridine; 2-bromo-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl..6 (trifluoromethyl)pyridine; 136 4 2 -(3-chloro-4-methoxyphenyl)-4,5-difluorophenyl)benzenesulfonainide; l-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)benzene; 5-difluoromethyl-4-(4-(methylsulfonyl)phenyl)-3-phenylisoxazole; 4-(3-ethyl-5-phenylisoxazol-4-yl)benzenesulfonamide; 4-(5-difluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 4-(5-hydroxymethyl-3-phenylisoxazol-4-yl)benzenesulfonamide; 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonaniide; l-(2-(4-fluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; l-(2-(4-fluoro-2-methylphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-chlorophenyl)cyclopenten- 1-yl)-4-(methylsulfonyl)benzene; l-(2-(2,4-dichlorophenyl)cyclopenten-1-yL)-4-(methylsulfonyl)benzene; boo"**l-(2-(4-trifluoromethylphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; too* l-(2-(4-methylthiophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(4-fluorophenyl)-4,4-dimethylcyclopenten- l-yl)-4- (methylsulfonyl)benzene; 4-(2-(4-fluorophenyl)-4,4-dimethylcyclopenten-1-yl)benzenesulfonamide; 1-(2-(4-chlorophenyl)-4,4-dimethylcyclopenten- l-yl)-4- (methylsulfonyl)benzene; 4-(2-(4-chlorophenyl)-4,4-dimethylcyclopenten-1-yl)benzenesulfonamide; 4 -(2-(4-fluorophenyl)cyclopenten- 1-yl)benzenesulfonamide; 4-(2-(4-chlorophenyl)cyclopenten- 1-yl)benzenesulfonamide; l-(2-(4-methoxyphenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 1-(2-(2,3-difluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 4-(2-(3-fluoro-4-methoxyphenyl)cyclopenten-1-yl)benzenesulfonamide; 1-(2-(3-chloro-4-methoxyphenyl)cyclopenten-1-yl)-4- (methylsulfonyl)benzene; 4-(2-(3-chloro-4-fluorophenyl)cyclopenten- 1-yl)benzenesulfonamide; 4-(2-(2-methylpyridin-5-yl)cyclopenten-1-yl)benzenesulfonamide; ethyl 2 -(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)-2- benzyl-acetate; 2-(4-(4-fluorophenyl)-5-( 4 -(methylsulfonyl)phenyl)oxazol-2-yl)acetic acid; <0tVTC 137 2-(tert-butyl)-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phelyl)oxazole; -4 fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-phenyloxazole; 4-(4-fluorophenyl)-2- methyl-5-(4-(methylsulfonyl)phenyl)oxazole; and 4-(5-(3-fluoro-4-methoxyphenyl)-2- trifluoromethyl-4-oxazolyl)benzenesulfonamide; or a pharmaceutically acceptable salt thereof, wherein said medicament is substantially as hereinbefore described. A pharmaceutical composition when prepared by the process of claim 26. A method of preventing or reducing the risk of developing an inflammatory disorder, for halting or slowing the progression of an inflammatory disorder, or for preventing or reducing the risk of occurrence or recurrence of an inflammatory disorder, said method comprising administration of an NK-l receptor antagonist combined with administration of a selective cycloxygenase-2 inhibitor, wherein said COX-2 inhibitor is selected from the group consisting of: 3-phenyl-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone; 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone; '5 5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3-(3-fluorophenyl)-5H-furan-2- one; 5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H-furan-2-one; 5-chloro-3-(4-(methylsulfonyl)phenyl)-2-(2-methyl-5-pyridinyl)pyridine; 2-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyelopenten-1-one-, 5(S)-5-ethyl-5-methyl-4-(4-(methylsulfonyl)phenyl)-3-(2-propoxy)-5H- furan-2-one; 5-ethyl-5-methyl-4-(4-(methylsulfonylphenyl)-3-(3,4-clifluorophenyl)-5H- furan-2-one; 00* 3-((2-thiazolyl)methoxy)-4-(4-(methylsulfonyl)phenyl)-5,5-dimethyl-5H- furan-2-one; 3-propyloxy-4-(4-(methylsulfonyl)phenyl)-5,5-dimethyl-5H-furan-2-one; 1-cyclopropylethoxy)-5,5-dimethyl-4-(4-methylsulfonyl)phenyl)-5H- furan-2-one; sodium 2-(4-chlorophenyl)-3-(4-(methylsulfonyl)phenyl)-4-oxo-2- pentenoate; [R:\LIB3H]021 2 I .doc :sxc 138 3 -(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H- furan-2-one; 3 -(cyclopropylmethoxy)-5,5-dimethy-4-(4-(methysufony)pheny).2,5. dihydrofuran-2-ol; 3 -isopropoxy-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)..25.dihydrofuran- 2-ol; 5,5-dimethy-3-(3-fluoropheny)-2-hydroxy-4-(4-(methysufonyl)pheny). 5-chloro-3-( 4 -(methylsulfonyl)pheny1)-2-(3-pyridinyl)pyricline; 4 -(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; 5-(4-fluorophenyl)-1- [4-(methylsulfonyl)phenylj -3- (trifluoromethyl)pyrazole; 4-(4-fluorophenyl)-5- [4-(methylsulfonyl)phenyl] -1-phenyl-3- (trifluoromethyl)pyrazole; 4 4 -chlorophenyl)-3-(4-methoxypheny)-lH-pyrazol-. 1 yl)benzenesulfonamide; 4-(3,5-bis(4-methylphenyl)- lH-pyrazol-1-yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-phenyl- lH-pyrazol-1-yl)benzenesulfonamjde; 4-(3,5-bis(4-methoxyphenyl)- 1H-pyrazol- 1-yl)benzenesulfonamide; 20 4 -(5-(4-chlorophenyl)-3-(4-methylphenyl)- 1H-pyrazol-1- yl)benzenesulfonamide; 4 4 -chlorophenyl)-3-(4-nitrophenyl)-lH-pyrazoli... yl)benzenesulfonamide; 4-(5-(4-chlorophenyl)-3-(5-cluoro-2-thyl)-H-pyrazol...1. 4-(4-phloro-35-dtiphl-1omty-H-pyrazol- -yl)benzenesulfonamide; 4-(5-(4-lorophenyl)-3-(trifluoromethyl)- 1H-pyrazol-l- yl)benzenesulfonamide; 139 4 4 -methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-l-. yl)benzenesulfonamide; 4 -(5-(4-chlorophenyl)-3-(difluoromethyl)-1H-pyrazol-l-. yl)benzenesulfonamide; 4 4 -methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1.. yl)benzenesulfonamide; 4 4 -chloro-5-(4-chloropheny)-3-(trifluoromethy)-lH-pyrazopl... yl)benzenesulfonamide; 4 -(3-(difluoromethyl)-5-(4-methylphenyl)-1H-pyrazol-l1. yl)benzenesulfonamide; 4-3(ilooehl--hnll-przl1y~eznsloaie 4 -(3-(difluoromethyl)-5-(4-methoxyphenyl)-H-pyrazol.1. yl)benzenesulfonamide; 4-(3-cyano-5-(4-fluorophenyl)- lH-pyrazol-1-yl)benzenesulfonamide; 4 3 -(difluoromethyl)-5-(3-fluoro-4-methoxypheny)1IHpyazol-l- yl)benzenesulfonamide; 4 3 -fluoro-4-methoxyphenyl)-3-(trifluoromethyl). H-pyrazol-1- yl)benzenesulfonamide; 4 4 -chloro-5-phenyl-1H-pyrazol-1-yl)benzenesulfonanmjde; 4 4 -chlorophenyl)-3-(hydroxyphenyl)-lHpyrazol-l yl)benzenesulfonamide; 4 4 -(N,N-dimethylamino)phenyl)-3-(trifluoromethyl)1lHpyrazol.1. yl)benzenesulfonamide; 4 -fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.4lhept-5-ene; 4-(6-(4-fluorophenyl)spiro 2 4 6-(4-fluorophenyl)-7-(4-(methylsulfonyl)phenyl)spiro oct-6-ene; 3 -chloro-4-methoxypheny1)-6-(4-(methylsulfonyl)phenyl)spiro [2.4]hept- 4 -(6-(3-chloro-4-methoxyphenyl)spiro [2.4lhept-5-en-5- yl)benzenesulfonamide; 140 5-(3 ,5-dichloro-4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)- spiro 5-(3-chloro-4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2 ene; 4-(6-(3,4-dichlorophenyl)spiro [2 4 2-(3-chloro-4-fluorophenyl)-4-(4-fluorophenyl)-5-(4- methylsulfonylphenyl)thiazole; 2 2 -chlorophenyl)-4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)tffiazole; 5-(4-fluorophenyl)-4-(4-methylsulfonylphenyl)-2-methyltfiazole; 4 4 -fluoropheny1)-5-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 4 4 -fluorophenyl)-5-(4-methylsulfonylphenyl)-2-(2-thienyl)thiazole; 4 4 -fluoropheny)-5-(4-methylsulfonylpheny1)-2-benzylaminothiazole; 4-4furpey)*-4mtysloylhnl -lpoplmn~haoe 2-((3,5-dichlorophenoxy)methyl)-4-(4-fluorophenyl).5(4- (methylsulfonyl)phenyl)thiazole; 4 -fluorophenyl)-4-(4-methylsulfonylphenyl)-2-trifluoromethylthiazole; 1-methylsulfonyl-4-( 1, l-dimethyl-4-(4-fluorophenyl)cyclopenta2,4-dien-3. yl)benzene; 4-(4-(4-fluorophenyl)-1, l-dimethylcyclopenta-2,4-dien-3- 20 ylbenzenesulfonamide; 4 -fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.4]hepta-4,6-diene; 4-(6-(4-fluorophenyl)spiro 2 4 lhepta-4,6-dien-5-yl)benzenesulfonan de; 6 4 -fluorophenyl)-2-methoxy-5-(4-(methylsulfonyl)phenyl)-py.jijne.3- carbonitrile; furpey)--4(ehlufoy~hnl--hey-yiie3 carbonitrile; 4 -urohenyin2y1))5-4-(mthyfuo1)hyl)..2..Heny1..pazol e..3. yl)benzenesuli'onamide; 14 1 4 2 -(5-methylpyridin-3-yl)-4-(trifluoromethyl)-lH-imidazol-l-1 yl)benzenesulfonamide; 4-(2-(2-methylpyridin-3-y1)-4-(trifluoromethy)-lH-imidazol-l- yl)benzenesulfonamide; 1-(4-(methylsulfony1)pheny1)-4-(trifluoromethy)-lH-imidazol.2. yl)benzenesulfonamide; 2-(l-(4-(methylsulfony1)phenyl)-4-(trifluoromethyl)1Hini~dazol12- yl)pyridine; 2-methyl-4-(1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethyl) 1H-imidazol- 2-yl)pyridine; 2 -methyl-6-(l-(4-(methylsulfony1)phenyl)-4-(trifluoromethyly..1Hjimdazo.. 2-yl)Pyridine; 4 2 -(6-methylpyridin-3-yl)-4-(trifluoromethyl)-lHiidazol-l-. yl)benzenesulfonamide; 2 3 4 -difluoropheny1)-1-(4-(methylsulfony1)pheny1)-4(trifluoromethyl)lH- imidazole; 4 2 4 -methylphenyl)-4-(trifluoromethyl)-lH-irmjdazoll yl)benzenesulfonamide; 2-(4-chlorophenyl)- l-(4-(methylsulfonyl)phenyl)-4-methyl- 1H-iinidazole; 2-(4-chlorophenyl)-4-(4-fluorophenyl)-1-(4-(methylsulfonyl)phenyl) 1H- imidazole; 2 3 -fluoro-4-methoxyphenyl)-1-(4-(methylsulfonyl)phenyl).4- (trifluoromethyl)-1H-imidazole; 1-4(ehlufnlpey)2pey--rfurmty-Hiiaoe 2 4 -methylphenyl)-1-(4-(methylsulfonyl)phenyl)y4-.tiifluoromethy..1H imidazole; 4 2 3 -chloro-4-methylpheny1)-4-(trifluoromethyl)lHimidazol-l-1 yl)benzenesulfonamide; 2-(3-fluoro-5-methylphenyl)- 1-(4-(methylsulfonyl)phenyl)-4- (trifluoromethyl)-1H-imidazole; 142 4 -(2-(3-fluoro-5-methylphenyl)-4-(trifluoromethy)-lH-iidazol-l-. yl)benzenesulfonamide; 2 -(3-methylphenyl)-1-(4-(methylsulfonyl)phenyl)-4-(trifluoromethy)1H- imidazole; 4-(2-(3-methylphenyl)-4-(trifluoromethyl)-H-imidazol-l-.. yl)benzenesulfonamide; 1-( 4 -(methylsulfony1)pheny1)-2-(3-chloropheny)-4(trifluoromethyl)lH- imidazole; 4-(2-(3-chlorophenyl)-4-(trifluoromethyl)-lH-imidazol-l yl)benzenesulfonaniide; 4 2 -phenyl- 4 -(trifluoromethy)-1H-imidazol1-y1)benzenesulfonamide; 4 -(2-(4-methoxy-3-chlorophenyl)-4-(trifluoromethyl)ylHjimdazo.ll- .9 *~.yl)benzenesulfonamide; l-allyl- 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)&5(trifluoromethyl)- 1H-pyrazole; l-ethyl-4-(4-fluorophenyl)-5-(trifluoromethyl).. H-pyrazol-3- yl)benzenesulfonamide; N-phenyl-(4-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-5-. (trifluoromethyl)-1H-pyrazol- 1-yl)acetamide; ethyl 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)5(trifluoromethyl). 1H-pyrazol-1-yl)acetate; 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)1.(2phenylethyl)lH- pyrazole; 4 4 -fluorophenyl)-3-(4-(methylsulfonyl)phenyl)1..(2-phenylethyl)5- (trifluoromethyl)pyrazole; l-ethyl- 4 -(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)5-(trifluoromethyl) 1H-pyrazole; 4 -fluorophenyl)- 4 4 -(methylsulfonyl)phenyl)-2-(trifluoromethyl). H- imidazole; 4 -(4-(methylsulfonyl)pheny1)-5-(2-thiophenyl)-2-(trifluoromethy) 1W- imidazole; 143 4 -fluorophenyl)-2-methoxy-4-(4-(methylsulfonyl)phenyl).6 (trifluoromethyl)pyridine; 2 -ethoxy-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-6. (trifluoromethyl)pyridine; 5-4furpey)4(-mtyslfnlpey)2(-rpnlx)6 (trifluoromethyl)pyridine; 2-bromo-5-(4-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)6- (trifluoromethyl)pyridine; 4-2(-hoo4mtoyhnl-,-dfurpey~eznsloaie l-( 4 -fluorophenyl)-2-(4-(methylsulfonyl)phenyl)benzene; 5-difluoromethyl-4-(4-(methysufony)pheny)-3-phenylisoxazole; 4 3 -ethyl-5-phenylisoxazol-4-yl)benzenesulfonamide; 4 -(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide; l-(2-(4-fluorophenyl)cyclopenten- l-yl)- 4 -(methylsulfonyl)benzene; l-( 2 4 -fluoro- 2 -methylpheny)cyclopenten-1-y)-4-(methylsulfonyl)benzene; l-(2-(4-chlorophenyl)cyclopenten- l-yl)-4-(methylsulfonyl)benzene; l-( 2 2 4 -dichlorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; l-( 2 4 -trifluoromethylphenyl)cyclopenten-1-y1)-4(methylsulfony1)benzene; l-( 2 4 -methylthiophenyl)cyclopenten-1-y)-4-(methylsulfonyl)benzene; l-( 2 4 -fluorophenyl)-4,4-dimethylcyclopenten-1-y).4 (methylsulfonyl)benzene; 4 2 4 -fluorophenyl)-4,4-dimethylcyclopenten- 1-yl)benzenesulfonamide; l-( 2 4 -chlorophenyl)-4,4-dimethylcyclopenten- l-yl)-4- (methylsulfonyl)benzene; 4 -(2-(4-chlorophenyl)-4,4-dimethylcyclopenten- l-yl)benzenesulfonamide; 4-(2-(4-fluorophenyl)cyclopenten- l-yl)benzenesulfonamide; 4 2 -(4-chlorophenyl)cyclopenten-1-yl)benzenesulfonamide; l-( 2 -(4-methoxyphenyl)cyclopenten-1-y1)-4-(methylsulfonyl)benzene; l-( 2 -(2,3-difluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene; 144 4-2(-loo4mtoyhnlccoetn1y~eznsloaie 1-(2-(3-chloro-4-methoxyphenyl)cyclopenten- l-yl)-4- (methylsulfonyl)benzene; 4-(2-(3-chloro-4-fluorophenyl)cyclopenten-1-yl)benzenesulfonamde; 4-(2-(2-methylpyridin-5-yl)cyclopenten-1-yl)benzenesulfonamide; ethyl 2-(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)-2 benzyl-acetate; 2-(4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazol-2-yl)acetic acid; 2-(tert-butyl)-4-(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)oxazole; 4 -(4-fluorophenyl)-5-(4-(methylsulfonyl)phenyl)-2-phenyloxazole; 4 4 -fluorophenyl)-2-methyl-5-(4-(methylsulfonyl)phenyl)oxazole; and 4-(5-(3-fluoro-4-methoxyphenyl)-2-trifluoromethyl-4- oxazolyl)benzenesulfonamnide; or a pharmaceutically acceptable salt thereof. Dated 21 January, 2003 Merck Sharp Dohme Limited Patent Attorneys for the Applicant/Nominated Person SPRUSON FERGUSON
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