AU747389B2 - Melt-extruded orally administrable opioid formulations - Google Patents

Description

MELT-EXTRUDED ORALLY ADMINISTRABLE OPIOID FORMULATIONS BACKGROUND OF THE INVENTION The present invention relates to the use of melt extrusion technology in the production ofbioavailable sustained-release matrix pharmaceutical formulations.

Previously, melt extrusion has been used in the production of immediate release formulations.

It is known in the pharmaceutical art to prepare compositions which provide for controlled release of pharmacologically active substances contained in the compositions after oral administration to humans and animals. Such slow release .1i, compositions are used to delay absorption of a medicament until it has reached certain portions of the alimentary tract. Such sustained-release of a medicament in the alimentary tract further maintains a desired concentration of said medicament in the *0o blood stream for a longer duration than would occur if conventional rapid release .dosage forms are administered.

Different methods of preparing controlled release pharmaceutical dosage forms have been suggested. For example, direct compression techniques, wet granulation techniques, encapsulation techniques and the like have been proposed to deliver 0 opharmaceutically active ingredients to the alimentary tract over extended periods.

Additionally, various types of sustained release formulations are known in the art, including specially coated pellets, coated tablets and capsules wherein the slow release of the active medicament is brought about through selective breakdown of the coating of the preparation or through compounding with a special matrix to affect the release of a drug. Some sustained release formulations provide for related sequential release of a single dose of an active compound at predetermined periods after administration.

It is the intent of all sustained-release preparations to provide a longer period of pharmacologic response after the administration of the drug and is ordinarily experienced after the administration of the rapid release dosage forms. Such longer periods of response provide for many inherent therapeutic benefits that are not achieved with corresponding short acting, immediate release preparations. This is especially true in the treatment of cancer patients or other patients in need of treatment for the alleviation of moderate to severe pain, where blood levels of an opioid analgesic medicament must be maintained at a therapeutically effective level to provide pain relief. Unless conventional rapid acting drug therapy is carefully administered at frequent intervals to maintain effective steady state blood levels of the drug, peaks and valleys in the blood level of the active drug occur because of the rapid absorption, systemic excretion of the compound and through metabolic inactivation. thereby producing special problems in maintenance of analgesic efficacy *i The prior art teaching of the preparation and use of compostlions providing the sustained-release of an active compound from a carrier is basicall\ concrncJ with the release of the active substance into the physiologic fluid of the alhmentan tract How- :20 ever, it is generally recognized that the mere presence of an acive substance in the gastrointestinal fluids does not, by itself, insure bioavailablht\ In order to be absorbed, the active drug substance must be in solution. The time required for a given proportion of an active substance from a unit dosage form is determined as the proportion of the amount of active drug substance released from a unit dosage form over a specified time base by a test method conducted under standardized conditions. The physiologic fluids of the gastrointestinal tract are the media for determining dissolution time. The present state of the art recognizes many satisfactory test procedures to measure dissolution time for pharmaceutical compositions, and these test procedures are described in official compendia world wide.

Although there are many diverse factors which influence the dissolution of drug substance from its carrier, the dissolution time determined for a pharmacologically active substance from the specific composition is relatively constant and reproducible.

Among the different factors affecting the dissolution time are the surface area of the drug substance presented to the dissolution solvent medium, the pH of the solution, the solubility of the substance in the specific solvent medium, and the driving forces of the saturation concentration of dissolved materials in the solvent medium. Thus, the dissolution concentration of an active drug substance is dynamically modified in its steady state as components are removed from the dissolution medium through absorption across the tissue site. Under physiologic conditions, the saturation level of the dissolved materials is replenished from the dosage form reserve to maintain a relatively uniform and constant dissolution concentration in the solvent medium "i providing for a steady state absorption.

I" 5 The transport across a tissue absorption site of the gastrointestinal tract is influenced by the Donnan osmotic equilibrium forces on both sides of the membrane since the direction of the driving force is the difference between the concentrations of active substance on either side of the membrane, the amount dissolved in the gastrointestinal fluids and the amount present in the blood. Since the blood levels are 0 constantly being modified by dilution, circulatory changes, tissue storage, metabolic o• conversion and systemic excretion, the flow of active materials is directed from the gastrointestinal tract into the blood stream.

Notwithstanding the diverse factors influencing both dissolution and absorption of a drug substance, a strong correlation has been established between the in-vitro dissolution time determined for a dosage form and (in-vivo) bioavailability. The dissolution time and the bioavailability determined for a composition are two of the most significant fundamental characteristics for consideration when evaluating sustained-release compositions.

Melt granulation techniques have also been suggested to provide controlled release formulations. Generally, melt granulation involves mechanically working an active ingredient in particulate form with one or more suitable binders and/or pharmaceutically acceptable excipients in a mixer until one or more of the binders melts and adheres to the surface of the particulate, eventually building up granules.

U.S. Patent No. 4,957,681 (Klimesch, et. al.) discloses a continuous process for preparing pharmaceutical mixtures having at least two components which are continuously metered. The process includes continuously metering the individual components of the pharmaceutical mixture at a rate of at least 50 g/h on electronic differential metering balances having a metering accuracy of at least 5% within time intervals of less than one minute and, additionally, having screw conveyors, thereby obtaining a substantially uniformly metered mixture; and shaping the mixture. Example 1 of the '681 patent is representative of the process. The requisite amounts of a 15 copolymer having a K value of 30 and obtained from 60% of N-vinylpyrrolid-2-one (NVP), stearyl alcohol and theophylline are metered via three metering balances into the hopper of an extruder and extruded. The temperatures of the extruder cylinder consisting of six shots ranged from 30-60"C and the die is heated to 100*C. The resultant extrudate is then pressed into tablets of the required shape. The '681 patent 2 :0 does not disclose preparation of sustained release opioid pharmaceutical formulations.

N. Follonier., et al., Hot-Melt Extruded Pellets for the Sustained Release of Highly Dosed Freely Soluble Drues, Proceed. Intern. Symp. Control. Rel. Bioact.

Mater., 18 (1991) describes certain diltiazem hydrochloride formulations prepared using hot-melt screw-extrusion to obtain sustained-release pellets to be filled into hard gelatin capsules. The polymers used were ethylcellulose, a copolymer ofehtyl acrylate and methyl methacrylate containing quaternary ammonium groups, cellulose acetate butyrate, poly(vinyl chloride-co-vinyl acetate) and a copolymer of ethylene and vinyl acetate. In order to lower the extrusion temperature, some plasticizers were used.

WO 93/07859 describes drug loaded pellets produced through melt spheronization wherein the therapeutically active agent is blended with various excipoients and binders; the formulation is fed to an extruder where it is heated and extruded at a speed of about 0.05 to 10 mm/sec. at approximately 60-180" C. The extrudate is then cut into pieces in a pelletizer and subsequently fed to a spheronizer for uniform pellet formulation.

Despite the foregoing advances and the various techniques for preparing sustained release formulations available in the pharmaceutical art, there is a need in the art for an orally administrable opioid formulation which would provide an extended duration of effect which is also easy to prepare, e.g via melt-granulation techniques.

SOBJECTS AND SUMMARY OF THE INVENTION It is therefore an object of the present invention to provide sustained- release pharmaceutical formulations suitable for oral administration and methods for preparing the same utilizing melt-extrusion techniques.

20 It is also an object of the present invention to provide improved methods for S* producing pharmaceutical extrudates containing opioid analgesics and pharmaceutical acceptable hydrophobic materials via melt extrusion techniques.

It is a further object of the present invention to provide a sustained-release melt extruded multi-particulate formulation which need not be spheronized in order to obtain a final dosage form..

It is also an object of the present invention to provide methods of treatment for human patients in need of opioid analgesic therapy using dosage forms prepared in 3 o accordance with the methods disclosed herein.

4 6 In accordance with the above objects and others which will be apparent from the further reading of the specification and of the appended claims, the present invention is related in part to the surprising discovery that sustained-release oral opioid analgesic formulations may be prepared utilizing melt extrusion techniques to provide bioavailable unit dose products which provide analgesia in a patient for, 8-24 hours.

The invention is also related in part to a new melt-extruded oral sustained-release dosage forms which comprise a pharmaceutically acceptable hydrophobic material, a retardant selected from waxes, fatty alcohols, and fatty acids, and a drug.

Accordingly, a first aspect of the present invention provides a unit dose sustained release oral io dosage form comprising a plurality of extruded particles, each of said particles consisting essentially of: an opioid analgesic dispersed in a matrix comprising one or more hydrophobic materials; and a retardant; said particles being non-spheroidal and having a length from about 0.1mm to about 12mm and 15 a diameter from about 0.1mm to about 5mm, said unit dose providing a release of said opioid analgesic over from about 8 hours to about 24 hours, said particles being formed by mixing the opioid analgesic, the one or more hydrophobic materials, and the retardant in an extruder to form said matrix, extruding the matrix in the extruder to form strands, and cutting said strands into said extruded particles.

20o A second aspect of the present invention provides a sustained-release particle comprising: an active agent selected from the group consisting of disinfecting agents, chemical impregnants, cleansing agents, deodorants, fragrances, dyes, animal repellents, insect repellents, fertilizing agents, pesticides, herbicides, fungicides and plant growth stimulants dispersed in a matrix comprising: at least one hydrophobic material; and a retardant selected from the group consisting of fatty alcohols, hydrogenated fats, fatty acid glycerides, hydrocarbons, waxes, hydrophobic and hydrophilic polymers having hydrocarbon backbones, fatty acid esters and mixtures thereof; said particle being non-spheroidal and having a length from about 0.1mm to about 12mm and a diameter from about 0.1mm to about 5mm and providing sustained release of said active agent, said particle being formed by mixing the active agent, the at least one hydrophobic material, and the retardant in an extruder to form said matrix, extruding the matrix in the extruder to form strands, and ting said strands into said extruded particles.

[R:\LIBA]469 .doc:mef 6a A third aspect of the present invention provides a sustained-release formulation comprising: a plurality of extruded particles, each of said particles comprising an opioid analgesic dispersed in a matrix comprising: one or more hydrophobic materials selected from the group consisting of ethylcellulose and acrylic polymers; and a retardant selected from the group consisting of fatty alcohols, hydrogenated fats, fatty acid glycerides, hydrocarbons, waxes, hydrophobic and hydrophilic polymers having hydrocarbon backbones, fatty acid esters and mixtures thereof; said particles being non-spheroidal and having a length from about O.1mm to about 12mm and a diameter from about O.1mm to about 5mm and providing sustained release of the opioid analgesic over from about 8 hours to about 24 hours, said particles being formed by mixing the opioid analgesic, the one or more hydrophobic materials, and the retardant in an extruder to form said matrix, extruding Sthe matrix in the extruder to form strands, and cutting said strands into said extruded particles.

A fourth aspect of the present invention provides a unit dose comprising: 15 a gelatin capsule containing a plurality of extruded particles, each of said particles comprising }o-an opioid analgesic dispersed in a matrix comprising: one or more hydrophobic materials selected from the group consisting of ethylcellulose, acrylic polymers and mixtures thereof; a retardant selected from the group consisting of stearic acid; and 20 a hydroxyalkycellulose; said particles being non-spheroidal and having a length from about O.1mm to about 12mm and a diameter from about O.1mm to about 5mm, said formulation providing sustained release of the opioid analgesic over from about 8 hours to about 24 hours, said particles being formed by mixing the opioid analgesic, the one or more hydrophobic materials, and the retardant in an extruder to form said matrix, extruding the matrix in the extruder to form strands, and cutting said strands into said extruded particles.

A fifth aspect of the present invention provides a method of preparing a multiparticulate sustained release oral dosage form, comprising the steps of: feeding, in powder form, a therapeutically active agent, and a hydrophobic material into an extruder; mixing together the therapeutically active agent and the hydrophobic material in the extruder to obtain a homogeneous mixture; S heating said homogeneous mixture in the extruder; [R:\LIBA]4691 .doc:mef extruding said homogeneous mixture with the extruder to thereby form strands; cooling said strands containing said homogeneous mixture; cutting said strands into generally cylindrically-shaped particles having a length from about 0.1 mm to about 12mm and a diameter of from about 0.1 mm to about 5mm; and dividing said generally cylindrically-shaped particles into unit doses, the ratio of said hydrophobic material to said therapeutically active agent in said mixture being sufficient to impart a release of said therapeutically active agent from said particles over a time period of from about 8 hours to about 24 hours when said particles are exposed to an aqueous fluid.

A sixth aspect of the present invention provides a method of treating a patient with a sustained 1o release multiparticulate formulation of a therapeutically active agent, comprising the steps of: feeding in powder form, a therapeutically active agent, and a hydrophobic material into an extruder; mixing together the therapeutically active agent and the hydrophobic material in the 4l66 4, 4 extruder to obtain a homogeneous mixture; 1 5 heating said homogeneous mixture in the extruder; o- extruding said homogeneous mixture with the extruder to thereby form strands; cooling said strands containing said homogeneous mixture; cutting said strands into generally cylindrically-shaped particles having a length of from about 0.1mm to about 12mm and a diameter of from about 0. lmm to about 3mm; 20 dividing said generally cylindrically-shaped particles into unit doses; and administering said unit dose to a patient, the ratio of said hydrophobic material to said :therapeutically active agent in said mixture being sufficient to impart a release of said therapeutically active agent from said particles over a time period of at least about 6 hours when said unit dose is administered to said patient.

A seventh aspect of the present invention provides a method of preparing a multiparticulate sustained release oral dosage form, comprising the steps of: directly metering into an extruder a hydrophobic material and a therapeutically active agent to obtain a homogeneous mixture; heating said homogeneous mixture; extruding said homogeneous mixture to thereby form strands; cooling said strands containing said homogeneous mixture; cutting said strands into generally cylindrically-shaped particles having a length of from about 0.1mm to about 12mm and a diameter of from about 0.1mm to about 3mm; and S(f) dividing said generally cylindrically-shaped particles into unit doses.

[R:\LIBA]469 .doc:mef 6c An eighth aspect of the present invention provides an opioid unit dose sustained-release oral dosage form having substantially no feeding-fasting effect, comprising a plurality of extruded particles, each of said particles comprising a matrix consisting essentially of: an opioid analgesic; one or more hydrophobic materials; said particles having a length from about 0.1mm to about 12mm and a diameter of from about 0.1mm to about 3mm, said unit dose providing a release of said opioid analgesic over at least about 12-24 hours, said particles being formed by mixing the opioid analgesic, the one or more hydrophobic materials, an optional retardant, and optional excipients in an extruder to form said matrix, extruding ,o the matrix in the extruder to form strands, and cutting said strands into said extruded particles.

Particularly, one aspect of the present invention is related to a pharmaceutical extrudate including an opioid analgesic dispersed in a matrix. Preferably, the extrudate is strand or spaghetti- Sshaped and has a diameter from about 0.1 to about 5mm. The extrudate is divide into unit doses of the opioid analgesic for oral administration to a patient, and provides a sustained analgesic effect for S is 8-24 hours or more.

The matrices preferably include a hydrophobic material and a second retardant material (preferably a hydrophobic fusible carrier) which acts to further slow or control the release of the therapeutically active agent when the formulation is expose to aqueous solutions in-vitro, or exposed to gastric and/or intestinal fluids.

S: 20 Preferably, the hydrophobic material is selected from the group consisting of alkylcelluloses, e* acrylic and methacrylic acid polymers and copolymers, shellac, zein, hydrogenated castor oil or hydrogenated vegetable oil, or mixtures thereof.

The retardant material (hydrophobic fusible carrier) is preferably selected from natural and synthetic waxes, fatty acids, fatty alcohols and mixtures of the same. synthetic waxes, fatty acids, fatty alcohols and mixtures of the same.

[R:\LIBA]4691 .doc:mef Examples include beeswax and carnauba wax, stearic acid, and stearyl alcohol. This list is of course not meant to be exclusive.

The extrudate may be cut into multiparticulates by any cutting means known in the art. Preferably, the multiparticulates have a length of from about 0.1 to 5 mm in length. The multiparticulates may then be divided into unit doses such that each individual unit dose includes a dose of opioid analgesic sufficient to provide analgesia to a mammal, preferably a human patient.

The unit doses of multiparticulates may then be incorporated into a solid pharmaceutical dosage formulation, e.g. via compression or shaping into tablets, by placing a requisite amount inside a gelatin capsule, or by forming the extruded product into the form of a suppository.

5 The pharmaceutical extrudates of the present invention may be prepared by blending the drug together with all matrix ingredients (hydrophobic material, binder and any additional (optional) excipients), feeding the resultant mixture into an extruder heated to the requisite temperature necessary to soften the mixture sufficiently to S.. render the mixture extrudable; extruding the viscous, heated mass as a spaghetti-like strand; allowing the extrudate to congeal and harden, and then dividing the strand into S" desired pieces. This may be accomplished, by cutting the strands into pellets of 1.5 mm in diameter and 1.5 mm in length. Preferably, the extrudate has a diameter of from about 0.1 to about 5 mm and provides sustained release of said opioid analgesic for a time period of from about 8 to about 24 hours.

Another aspect of the invention is directed to pharmaceutical dosage forms including the extrudate prepared as outlined above. The extrudate is cut into multiparticulates using any cutting means known in the art, e.g a blade. The multiparticulates are then divided into unit doses containing an effective amount of opioid analgesic to provide analgesia or pain relief in a human patient over the desired dosing interval. The unit dose of multiparticulates may then be incorporated into tablets, e.g. via direct compression, formed into suppositories, or encapsulated by any means known in the art.

In yet a further aspect of the invention, there is provided a method of treating a patient with sustained-release formulations prepared as described above. This method includes administering a dosage form containing the novel extrudate to a patient in need ofopioid analgesic therapy. For purposes of the present invention, a unit dose is understood to contain an effective amount of the therapeutically active agent to produce pain relief and/or analgesia to the patient. One skilled in the art will recognize that the dose of opioid analgesic administered to a patient will vary due to numerous factors; e.g. the specific opioid analgesic(s) being administered, the weight and tolerance of the patient, other therapeutic agents concomitantly being administered, etc.

As mentioned above, in order for a dosage form to be effective for its intended purpose, the dosage form must be bioavailable. For purposes of the present invention, the term "bioavailable" is defined as the total amount of a drug substance that is absorbed and available to provide the desired therapeutic effect after administration of *20 a unit dosage form. Generally, the bioavailability of a given dosage form is determined S: by comparison to a known reference drug product, as commonly determined and accepted by Governmental Regulatory Agencies, such as the United States FDA.

The term "bioavailability" is defined for purposes of the present invention as the extent to which the drug opioid analgesic) is absorbed from the unit dosage form and is available at the site of drug action.

The terms "sustained release", "extended duration", and "controlled release" are defined for purposes of the present invention as the release of the drug opioid analgesic) at such a rate that blood plasma) levels are maintained within the therapeutic range but below toxic levels over a period of time greater than 8 hours, more preferably for about 12 to about 24 hours, or longer.

The term "unit dose" is defined for purposes of the present invention as the total amount of multiparticulates needed to administer a desired dose of therapeutically active agent opioid analgesic) to a patient.

The extrudates of the present invention preferably permit release of the opioid (or salts thereof) over a sustained period of time in an aqueous medium. The term "aqueous medium" is defined for purposes of the present invention as any watercontaining medium, e.g. water, pharmaceutically acceptable dissolution medium, gastric fluid and/or intestinal fluid and the like.

O*

SBRIEF DESCRIPTION OF THE DRAWINGS The following drawing is illustrative of an embodiment of the invention and is not meant to limit the scope of the invention as encompassed by the claims.

44 4 9O 9* Figure 1 is a graph displaying the dissolution results of Examples I and 2; •Figure 2 is a graph displaying the dissolution rates of Examples 3-6; Figures 3 and 4 are graphs displaying the pH dependency of the dissolution results of Examples 3 and 6 respectively; Figure 5 is a graph displaying the dissolution results of Examples 7 and 8 vs.

Example 6; Figure 6 is a graph displaying the dissolution results of Examples 9 and Figure 7 is a graph displaying the dissolution results of Examples 11 and 12; Figure 8 is a graph displaying the dissolution results of Examples 15 and 16; Figure 9 is a schematic representation of a system for carrying out the present 3 0 invention; Figure 10 is a graph displaying the fed/fast bioavailability results for Example Figure 11 is a graph displaying the plasma morphine concentrations of Example 21 obtained from administration of the capsules from Example 6 vs. MS Contin Figure 12 is a graph displaying the plasma oxycodone concentrations of Example 22 obtained from administrating the capsules from Examples 11 and 13 vs.

OxyContin Figure 13 is a graphical representation of the plasma oxycodone concentrations of Example 14; Figure 14 is a graphical representation of the hydromorphone concentrations of Example 24 using the capsules from Example 17 vs. Dilaudid®; Figure 15 is a graph displaying the plasma hydromorphone concentrations of Example 24 using capsules from Example 18 vs. Dilaudid®; Figure 16 is a graph of the steady-state plasma hydromorphone concentrations 15 of Example 25 using the capsules of Example 17; and Figure 17 is a graph of the plasma hydromorphone concentrations of Example 26 using the capsules of Example 19.

DETAILED DESCRIPTION In one aspect of the invention, the sustained-release dosage forms comprise an opioid analgesic as the therapeutically active agent. In such formulations, the drug is incorporated into a melt-extruded strand which includes a pharmaceutically acceptable hydrophobic material such as an alkylcellulose or an acrylic polymer or copolymer. In certain embodiments, it is preferably to further add to the blend a plasticizer for the hydrophobic material in order to reduce the extrusion temperature. The choice of the most suitable plasticizer is made based on its ability to lower the glass transition temperature (Tg) of the polymer. In preferred alternative embodiments, a hydrophobic fusible carrier (which may also act as a binder) is utilized instead of a plasticizer. The hydrophobic fusible carrier preferably imparts a slower release of the therapeutically active agent from the melt extruded formulation. Any further pharmaeutical excipients known to those skilled in the art may be added as deemed necessary.

Another aspect of the invention is directed to improved melt extruded matrices which comprise a hydrophobic material and a fatty binder such as previously specified.

In accordance therewith, a therapeutically active agent is combined with one or more suitable hydrophobic materials and a hydrophobic fusible carrier is extruded to form an extrudate. The extrudate may then be cut into multiparticulates which are subsequently incorporated into sustained release dosage forms.

Tharapeutically Active Agents *9 9 Therapeutically active agents which may be used in accordance with the present invention include both water soluble and water insoluble drugs. Examples of such therapeutically active agents include antihistamines dimenhydrinate, diphenhydramine, chlorpheniramine and dexchlorpheniramine maleate), analgesics aspirin, codeine, morphine, dihydromorphone, oxycodone, etc.), non-steroidal anti-inflammatory agents naproxen, diclofenac, indomethacin, ibuprofen, sulindac), anti-emetics metoclopramide, methylnaltrexone), anti-epileptics phenytoin, meprobamate and nitrazepam), vasodilators nifedipine, papaverine, diltiazem and nicardipine), anti-tussive agents and expectorants codeine phosphate), anti-asthmatics theophylline), antacids, anti-spasmodics (e.g.

atropine, scopolamine), antidiabetics insulin), diuretics ethacrynic acid, bendrofluthiazide), anti-hypotensives propranolol, clonidine), antihypertensives clonidine, methyldopa), bronchodilators albuterol), steroids hydrocortisone, triamcinolone, prednisone), antibiotics tetracycline), antihemorrhoidals, hypnotics, psychotropics, antidiarrheals, mucolytics, sedatives, decongestants, laxatives, vitamins, stimulants (including appetite suppressants such as phenylpropanolamine), as well as salts, hydrates, and solvates of the same.

In embodiments of the invention directed to opioid analgesics, the opioid analgesics used in accordance with the present invention include alfentanil, allylprodine, alphaprodine, anileridine, benzylmorphine, bezitramide, buprenorphine, butorphanol, clonitazene, codeine, cyclazocine, desomorphine, dextromoramide, dezocine, diampromide, dihydrocodeine, dihydromorphine, dimenoxadol, dimepheptanol, dimethylthiambutene, dioxaphetyl butyrate, dipipanone, eptazocine, ethoheptazine, ethylmethylthiambutene, ethylmorphine, etonitazene fentanyl, heroin, hydrocodone, hydromorphone, hydroxypethidine, isomethadone, ketobemidone, levallorphan, levorphanol, levophenacylmorphan, lofentanil, meperidine, meptazinol, metazocine, methadone, metopon, morphine, myrophine, nalbuphine, narceine, nicomorphine, norlevorphanol, normethadone, nalorphine, normorphine, norpipanone, opium, oxycodone, oxymorphone, papaveretum, pentazocine, phenadoxone, S: phenomorphan, phenazocine, phenoperidine, piminodine, piritramide, propheptazine, promedol, properidine, propiram, propoxyphene, sufentanil, tramadol, tilidine, salts if 5 thereof, mixtures of any of the foregoing, mixed mu-agonists/antagonists, muantagonist combinations, and the like. The opioid analgesic may be in the form of the free base, or in the form of a pharmaceutically acceptable salt, or in the form of a pharmaceutically acceptable complex.

In certain preferred embodiments, the opioid analgesic is selected from morphine, codeine, hydromorphone, hydrocodone, oxycodone, dihydrocodeine, dihydromorphine, oxymorphone, tramadol or mixtures thereof.

In one preferred embodiment the sustained-release opioid oral dosage form of the present invention includes hydromorphone as the therapeutically active ingredient in an amount from about 4 to about 64-mg hydromorphone hydrochloride.

Alternatively, the dosage form may contain molar equivalent amounts of other hydromorphone salts or of the hydromorphone base. In other preferred embodiments where the opioid analgesic is other than hydromorphone, the dosage form contains an appropriate amount to provide a substantially equivalent therapeutic effect. For example, when the opioid analgesic comprises morphine, the sustained-release oral dosage forms of the present invention include from about 5 mg to about 800 mg morphine, by weight (based on morphine sulfate). When the opioid analgesic comprises oxycodone, the sustained-release oral dosage forms of the present invention include from about 5 mg to about 400 mg oxycodone. When the opioid analgesic is tramadol, the sustained-release oral dosage forms of the invention include from about mg to about 800 mg tramadol by weight, based on the hydrochloride salt.

The sustained-release dosage forms of the present invention generally achieve and maintain therapeutic levels substantially without significant increases in the intensity and/or degree of concurrent side effects, such as nausea, vomiting or drowsiness, which are often associated with high blood levels ofopioid analgesics.

There is also evidence to suggest that the use of the present dosage forms leads to a reduced risk of drug addiction.

S In the present invention, the oral opioid analgesics have been formulated to provide for an increased duration of analgesic. Surprisingly, these formulations, at comparable daily dosages of conventional immediate-release drug, are associated with a lower incidence in severity of adverse drug reactions and can also be administered at o.0 a lower daily dose than conventional oral medication while maintaining pain control.

When the therapeutically active agent included in the dosage forms of the present invention is an opioid analgesic, the dosage form may further include one or more additional which may or may not act synergistically with the opioid analgesics of the present invention. Examples of such additional therapeutically active agents include non-steroidal anti-inflammatory agents, including ibuprofen, diclofenac, naproxen, benoxaprofen, flurbiprofen, fenoprofen, flubufen, ketoprofen, indoprofen, piroprofen, carprofen, oxaprozin, pramoprofen, muroprofen, trioxaprofen, suprofen, aminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, indomethacin, sulindac, tolmetin, zomepirac, tiopinac, zidometacin, acemetacin, fentiazac, clidanac, oxpinac, 14 mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid tolfenamic acid, diflurisal, flufenisal, piroxicam, sudoxicam or isoxicam, and the like. Other suitable additional drugs which may be included in the dosage forms of the present invention include acetaminophen, aspirin, salicylate-derived analgesics and antipyretics or salts thereof, and other non-opioid analgesics.

The additional (non-opioid) therapeutically active agent may be included in controlled release form or in immediate release form. The additional drug may be incorporated into the controlled release matrix along with the opioid; incorporated as a separated controlled release layer or immediate release layer; or may be incorporated as a powder, granulation, etc., in a gelatin capsule with the extrudates of the present invention.

Matrix Ingredients The extrudates of the present invention include at least one hydrophobic eoc material. The hydrophobic material will preferably impart sustained release of the opioid analgesic to the final formulation. Preferred hydrophobic materials which may be used in accordance with the present invention include alkylcelluloses such as natural 20 or synthetic celluloses derivatives ethylcellulose), acrylic and methacrylic acid polymers and copolymers, shellac, zein, wax-type substances including hydrogenated castor oil or hydrogenated vegetable oil, or mixtures thereof This list is not meant to be exclusive, and any pharmaceutically acceptable hydrophobic material which is capable of imparting sustained release of the active agent and which melts (or softens to the extent necessary to be extruded) may be used in accordance with the present invention.

In certain preferred embodiments of the present invention, the hydrophobic material is a pharmaceutically acceptable acrylic polymer, including but not limited to acrylic acid and methacrylic acid copolymers, methyl methacrylate, methyl methacrylate copolymers, ethoxyethyl methacrylates, cynaoethyl methacrylate, aminoalkyl methacrylate copolymer, poly(acrylic acid), poly(methacrylic acid), methacrylic acid alkylamine copolymer, poly(methyl methacrylate), poly(methacrylic acid)(anhydride), polymethacrylate, polyacrylamide, poly(methacrylic acid anhydride), and glycidyl methacrylate copolymers. In other embodiments, the hydrophobic material is selected from materials such as hydroxyalkylcelluloses such as hydroxypropylmethylcellulose and mixtures of the foregoing.

The retardant material is preferably a hydrophobic fusible carrier which may comprise one or more water-insoluble wax-like thermoplastic substances possibly mixed with one or more wax-like thermoplastic substances being less hydrophobic than said one or more water-insoluble wax-like substances. In order to achieve constant release, the individual wax-like substances in the binder material should be substantially non-degradable and insoluble in gastrointestinal fluids during the initial release phases.

'Useful water-insoluble wax-like substances may be those with a watersolubility that is lower than about 1:5,000 (w/w) Such hydrophobic fusible carrier materials are preferably watr -insoluble with :2 more or less pronounced hydrophilic and/or hydrophobic trends Prcf-ra y. the retardant materials useful in the invention have a melting point trom ajt,ut 10 to about 200*C, preferably from about 45 to about 90°C. Specifically, the hydrophobic fusible carrier may comprise natural or synthetic waxes fatty alcohols (such as lauryl, myristyl stearyl, cetyl or preferably cetostearyl alcool), fatty acids, including but not limited to fatty acid esters, fatty acid glycerides (mono-, di-, and tri-glycerides), hydrogenated fats, hydrocarbons, normal waxes, stearic aid, stearyl alcohol and hydrophobic and hydrophilic polymers having hydrocarbon backbones. Suitable waxes include, for example, beeswax, glycowax, castor wax and carnauba wax. For purposes of the present invention, a wax-like substance is defined as any material which is 16 normally solid at room temperature and has a melting point of from about 30 to about 100 0

C.

Suitable hydrophobic fusible carrier materials which may be used in accordance with the present invention include digestible, long chain especially C, 2 substituted or unsubstituted hydrocarbons, such as fatty acids, fatty alcohols, glyceryl esters of fatty acids, mineral and vegetable oils and natural and synthetic waxes.

Hydrocarbons having a melting point of between 250 and 90 0 C are preferred. Of the long chain hydrocarbon materials, fatty (aliphatic) alcohols are preferred in certain embodiments.. The oral dosage form may contain up to 60% (by weight) of at least one digestible, long chain hydrocarbon.

In addition to the above ingredients, a sustained-release matrix may also contain suitable quantities of other materials, diluents, lubricants, binders, .5 granulating aids, colorants, flavorants and glidants that are conventional in the pharmaceutical art. The quantities of these additional materials will be sufficient to provide the desired effect to the desired formulation. In addition to the above ingredients, a sustained-release matrix incorporating melt-extruded multiparticulates may also contain suitable quantities of other materials, e.g. diluents, lubricants, binders, granulating aids, colorants, flavorants and glidants that are conventional in the S: pharmaceutical an in amounts up to about 50% by weight of the particulate if desired.

Specific examples of pharmaceutically acceptable carriers and excipients that may be used to formulate oral dosage forms are described in the Handbook of Pharmaceutical Excipients, American Pharmaceutical Association (1986), incorporated by reference herein.

In order to facilitate the preparation of a solid, sustained-release oral dosage form according to this invention there is provided, in a further aspect of the present invention, a process for the preparation of a solid, sustained-release oral dosage form according to the present invention comprising incorporating opioids or a salt thereof in a sustained-release melt-extruded matrix. Incorporation in the matrix may be effected, for example, blending the opioid analgesic, together with at least one hydrophobic material and preferably the additional retardant material (hydrophobic fusible carrier) to obtain a homogeneous mixture. The homogeneous mixture is then heated to a temperature sufficient to at least soften the mixture sufficiently to extrude the same.

The resulting homogeneous mixture is then extruded, using a twin-screw extruder, to form strands. The extrudate is preferably cooled and cut into multiparticulates by any means known in the art. The strands are cooled and cut into multiparticulates. The multiparticulates are then divided into unit doses. The extrudate preferably has a diameter of from about 0.1 to about 5 mm and provides sustained release of the therapeutically active agent for a time period of from about 8 to about 24 hours.

An optional process for preparing the melt extrusions, multiparticulates and 15 unit doses of the present invention includes directly metering into an extruder a waterinsoluble retardant, a therapeutically active agent, and an optional binder; heating said homogenous mixture; extruding said homogenous mixture to thereby form strands; cooling said strands containing said homogeneous mixture; and cutting said strands into particles having a size from about 0. 1 mm to about 12 mm; and dividing said particles into unit doses. In this aspect of the invention, a relatively continuous manufacturing procedure is realized.

The diameter of the extruder aperture or exit port can also be adjusted to vary the thickness of the extruded strands. Furthermore, the exit part of the extruder need not be round; it can be oblong, rectangular, etc. The exiting strands can be reduced to particles using a hot wire cutter, guillotine, etc.

The melt extruded multiparticulate system can be, for example, in the form of granules, spheroids or pellets depending upon the extruder exit orifice. For purposes of the present invention, the terms "melt-extruded multiparticulate(s)" and "meltextruded multiparticulate system(s)" and "melt-extruded particles" shall refer to a plurality of units, preferably within a range of similar size and/or shape and containing one or more active agents and one or more excipients, preferably including a retardant as described herein. In this regard, the melt-extruded multiparticulates will be of a range of from about 0.1 to about 12 mm in length and have a diameter of from about 0. 1 to about 5 mm. In addition, it is to be understood that the melt-extruded multiparticulates can be any geometrical shape within this size range such as beads, microspheres, seeds, pellets, etc.

A particular advantage provided by the invention is the preparation of sustained-release melt-extruded multiparticulate formulations which do not require further processing, the extrudate may simply be cut into desired lengths and divided into unit doses of the therapeutically active agent without the need of a spheronization step.

In one preferred embodiment, oral dosage forms are prepared to include an effective amount of melt-extruded multiparticulates within a capsule. For example, a plurality of the melt-extruded multiparticulates may be placed in a gelatin capsule in an amount sufficient to provide an effective sustained-release dose when ingested and 20 contacted by gastric fluid.

In another preferred embodiment, a suitable amount of the multiparticulate extrudate is compressed into an oral tablet using conventional tableting equipment using standard techniques. Techniques and compositions for making tablets (compressed and molded), capsules (hard and soft gelatin) and pills are also described in Remington's Pharmaceutical Sciences, (Arthur Osol, editor), 1553-1593 (1980), incorporated by reference herein.

In yet another preferred embodiment, the extrudate can be shaped into tablets as set forth in U.S. Patent No. 4,957,681 (Klimesch, et. described in addtional detail above and hereby incorporated by reference.

In yet a further embodiment, the extrudate can be shaped into suppositories containing a unit dose of the therapeutically active agent. This may be accomplished using techniques and equipment well known to those skilled in the art.

Optionally, the sustained-release melt-extruded multiparticulate systems or tablets can be coated, or the gelatin capsule can be further coated, with a sustainedrelease coating comprising one of the hydrophobic materials described above. Such coatings preferably include a sufficient amount of hydrophobic material to obtain a weight gain level from about 2 to about 30 percent, although the overcoat may be greater depending upon the physical properties of the particular opioid analgesic S1' compound utilized and the desired release rate, among other things. In certain preferred embodiments of the present invention, the hydrophobic polymer comprising the sustained-release coating is a pharmaceutically acceptable acrylic polymer, such as those described hereinabove. The solvent which is used for the hydrophobic material in the coating may be any pharmaceutically acceptable solvent, including water, 20 methanol, ethanol, methylene chloride and mixtures thereof The unit dosage forms of the present invention may further include combinations of melt-extruded multiparticulates containing one or more of the therapeutically active agents disclosed above before being encapsulated. Furthermore, the unit dosage forms can also include an amount of an immediate release therapeutically active agent for prompt therapeutic effect. The immediate release therapeutically active agent may be incorporated, as separate pellets within a gelatin capsule, or may be coated on the surface of the compressed tablet which has been prepared from the multiparticulate extrudate as set forth above.

The controlled-release formulations of the present invention slowly release the therapeutically active agent, when ingested and exposed to gastric fluids, and then to intestinal fluids. The controlled-release profile of the melt-extruded formulations of the invention can be altered, for example, by varying the amount of retardant, i.e., hydrophobic polymer, by varying the amount of plasticizer relative to hydrophobic polymer, by the inclusion of additional ingredients or excipients, by altering the method of manufacture, etc. In certain embodiments of the invention, the the sustained-release dosage forms of the present invention preferably release the therapeutically active agent at a rate that is independent ofpH, between pH 1.6 and 7.2. In other embodiments, the formulations can be designed to provide a pH-dependent release of the therapeutically active agent.

In other embodiments of the invention, the melt extruded material is prepared without the inclusion of the therapeutically active agent, which is added therafter to the extrudate. Such formulations typically will have the therapeutically aciive agent blended together with the extruded matrix material, and then the mixture would be tabletted in order to provide a slow release formulation Such formulanons may be advantageous, for example, when the therapeutically acti e a ecnt in,nJJc in the 2 0nformulation is sensitive to temperatures needed for soficnin thc h Jri,;phbhi material 20 and/ or the retardant material.

Opioid Analgesic Formulations In certain preferred embodiments, the invention is directed to sustained-release oral opioid formulations which are administrable on a once-a-day basis, and which are prepared from the melt extrudates described herein. Such dosage forms will provide an in-vitro release (when assessed by the USP Paddle or Basket Method at 100 prm at 900 ml aqueous buffer (pH between 1.6 and 7.2) at 37*C from about 1 to about 42.5% opioid released after one hour, from about 5 to about 65% opioid released after 2 hours, from about 15 to about 85% opioid released after 4 hours, from about 20 to about 90% opioid released after 6 hours, from about 35 to about 95% opioid released after 12 hours, from about 45 to about 100% opioid released after 18 hours, and from about 55 to about 100% opioid released after 24 hours, by weight. Such formulations may further be characterized by a peak plasma level at from about 2 to about 8 hours after oral administration, and preferably from about 4 to about 6 hours after administration. Such formulations are further characterized by a Wso from about 4 to about 12 hours.

In certain preferred embodiments, the oral 24 hour sustained-release opioid dosage form provides a rapid rate of initial rise in the plasma concentration of the opioid after oral administration, such that the peak plasma level obtained in-vivo occurs from about 2 to about 8 hours after oral administration, and/or the absorption de C half-life is from about I to about 8 hours after oral administration (in the fasted state).

s More preferably in this embodiment the absorption half-life is 1-6 hours and possibly o 1-3 hours after oral administration (in the fasted state). Such formulations provide an in-vitro dissolution under the conditions specified above, from about 12.5 to about 42.5% opioid released after one hour, from about 25 to about 65% opioid released after 2 hours, from about 45 to about 85% opioid released after 4 hours, and greater 0 than about 60% opioid released after 8 hours, by weight.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The following examples illustrate various aspects of the present invention.

They are not to be construed to limit the claims in any manner whatsoever.

MELT-EXTRUSION TECH NIOUES Typical melt extrusion systems capable of carrying-out the present invention include a suitable extruder drive motor having variable speed and constant torque control, start-stop controls, and ammeter. In addition, the system will include a temperature control console which includes temperature sensors, cooling means and temperature indicators throughout the length of the extruder. In addition, the system will include an extruder such as twin-screw extruder which consists of two counterrotating intermeshing screws enclosed within a cylinder or barrel having an aperture or die at the exit thereof. The feed materials enter through a feed hopper and is moved through the barrel by the screws and is forced through the die into strands which are thereafter conveyed such as by a continuous movable belt to allow for cooling and being directed to a pelletizer or other suitable device to render the extruded ropes into the multiparticulate system. The pelletizer can consist of rollers, fixed knife, rotating cutter and the like. Suitable instruments and systems are available from distributors such as C.W. Brabender Instruments, Inc. of South Hackensack, New Jersey. Other suitable apparatus will be apparent to those of ordinary skill in the art.

4 .15 A further aspect of the invention is related to the preparation of melt extruded multiparticulates as set forth above in a manner which controls the amount of air included in the extruded product. By controlling the amount of air included in the extrudate, it has been surprisingly found that the release rate of the therapeutically o.* active agent from the, multiparticulate extrudate, can be altered significantly.

o In certain embodiments, it has been surprisingly found that the pH dependency of the extruded product can be altered as well.

Thus, in a further aspect of the invention, the melt extruded product is prepared in a manner which substantially excludes air during the extrusion phase of the process.

This may be accomplished, for example, by using a Leistritz extruder having a vacuum attachment. It has been surprisingly found that extruded multiparticulates prepared according to the invention using the Leistritz extruder under vacuum provides a meltextruded product having different physical characteristics. In particular, the extrudate is substantially non-porous when magnified, using a scanning electron microscope which provides an SEM (scanning electron micrograph). Contrary to conventional 23 thought, it has been found that such substantially non-porous formulations provide a faster release of the therapeutically active agent, relative to the same formulation prepared without vacuum. SEMs of the multiparticulates prepared using an extruder under vacuum appear very smooth, and the multiparticulates tend to be more robust than those multiparticulates prepared without vacuum. It has been observed that in at least certain formulations, the use of extrusion under vacuum provides an extruded multiparticulate product which is more pH-dependent than its counterpart formulation prepared without vacuum.

General Pellet Manufacturing Procedure The following technique was used to manufacture the extrudate and multiparticulates for Examples 1-26: Blend the required amount of drug, hydrophobic material and binder along with any additional excipients.

Charge a powder feeder with proper amount of drug/ excipient blend.

Set temperatures of extruder heating zones to the required temperature, depending on the formulation. Typically, the temperature should be set at about 83" C. Wait until the corresponding heating zones reach steady temperatures. Set the extruder screw rotation speed to 20 rpm Start the feeder, the conveyor and the pelletizer. After the excipients are melted and the drug is embedded in the molten mixture, the resultant viscous mass is extruded as spaghetti-like strands. The diameter of the extruder aperture can be adjusted to vary the thickness of the resulting strand.

Set the conveyor belt speed to an appropriate speed 3-100 ft/min).

Allow the extruded semisolid strand(s) to be congealed and/or hardened while 2 5 transported to the pelletizer on the conveyor belt. Additional cooling devices may be needed to ensure proper congealing. (The conveyor belt may not be needed to cool the strand, if the material congeals rapidly enough.) Set the roller knife to an appropriate speed to 3-100 ft/min and 100-800 rpm). Cut the congealed strands to desired size 3-5 mm in diameter, 0.3-5 mm in length).

Collect the pellet product.

Fill a desired weight of pellets into hard gelatin capsules to obtain an appropriate doses of the drug.

Dissolution Method The following dissolution method was used to obtain dissolution profiles for the dosage forms of Examples 1-25: (USP II Paddle at 100 rpm at 37 0

C)

Media 1st hour in 700 ml simulated gastric fluid (SGF), pH 1.2 without enzyme thereafter, 900 ml simulated intestinal fluid (SIF), pH 7.5 without enzyme Using HPLC procedures for assay The following examples illustrate various aspects of the present invention.

They are not meant to be construed to limit the claims in any manner whatsoever.

EXAMPLES 1-2 CONTROLLED RELEASE CHLORPHENIRAMINE FORMULATIONS In these examples, chlorpheniramine maleate controlled release pellets were prepared according to the above manufacturing procedure using ethylcellulose and an acrylic polymer (Eudragit RSPO), respectively as the retardant. The formulations are set forth in Tables 1 and 2 below. The dissolution of these formulations is set forth in Figure 1. Drug release rate from ethylcellulose pellets (prepared at 105°C) is significantly slower than that from Eudragit RSPO pellets (prepared at EX. I TABLE 1 Composition Amt. (mg) per Capsule Chlorpheniramine Maleate Ethyl Cellulose 84 Stearic Acid 36 Total 180 EX. 2 TABLE 2 Composition Amt. (mg) per Capsule Chlorpheniramine Maleate Eudragit RSPO 84 Stearic Acid 36 Total 180 EXAMPLES 3-6 CONTROLLED RELEASE MORPHINE FORMULATIONS Ex.3 The excipients used in Ex. 2 were employed to make morphine sulfate controlled release pellets.

EX. 3 TABLE 3 Composition Anmt. (mg) per Cap'ule Morphine Sulfate Eudragit RSPO 42 Stearic Acid I8 Total 120 The drug release rate of Example 3 was slower than expected especially during later hours of the dissolution.

Ex. 4-5 Examples 4-5 were prepared in accordance with Example 3 above. To increase the drug dissolution rate during later hours, varying amounts of Eudragit L-100 were incorporated in the formulation. The drug dissolution rate increases with increasing amount of Eudragit L-l100 in the formulation. The morphine sulfate capsule formulation are set forth in tables 4-6 below: EX. 4 TABLE 4 Composition Amt. (mg) per Capsule Morphine Sulfate Eudragit RSPO 38.4 Eudragit L-100 3.6 Stearic Acid 18 Total 120 EX. 5 Composition Amt. (mg) per Capsule Morphine Sulfate Eudragit RSPO 33.6 Eudragit L-1008.

Stearic Acid 18 Total 120 Ex. 6. A sustained release morphine sulfate formulation was prepared having the ingredients listed in Table 6 below:

S..

S.

S

S

TABLE 6 Ingredients Amt(mg)/Capsule Percentage in Formula Morphine Sulfate 60 Eudragit RSPO 36 Eudragit L-100 6 Stearic Acid 18 Total 120 100 The formulation of Example 6 was prepared as follows: Pellet Manufacture a. Extruder system description- The twin screw extruder is consisted of a pair of counterrotating screws and a barrel block equipped with heating/cooling zones. The extrudate is delivered to a pelletizer through a conveyor belt and cut into pellets of the desirable size.

b. Manufacturing procedure- 1. Blend the drug and all the excipients in a proper mixer.

2. Place the mixture in a powder feeder.

3. Set temperatures of the extruder heating zones to approximately 83 0

C.

4. Set the extruder screw rotation speed to 20 rpm.

Start the feeder, the conveyor and the pelletizer.

6. After the excipients are melted and the drug embedded in the molten mixture, the viscous mass is extruded as spaghetti-like strands.

7. The extrudate is congealed and hardened while being delivered to the pelletizer on the conveyor belt.

8. The roller knife of the pelletizer cuts the strands into pellets of 1.5 mm in diameter and 1.5 mm in length.

Encapsulation After the pellets were manufactured, 120 mg of pellets are encapsulated in size #2 hard gelatin capsules, rendering capsules containing 60 mg of morphine sulfate.

These capsules were then tested using the following dissolution methodology: The capsules of Example 6 were found to have the following dissolution results: Time (hr) 1 2 4 8 12 18 24 Mean dissolved 16 33 52 72 84 95 102 As seen in Figure 3, the drug dissolution rate obtained from the product of Ex.

3 showed a significant pH dependency. The release rate was slower in SIF (simulated intestinal fluid) than in SGF (simulated gastric fluid).

In Figure 4, it can be seen that due to the addition of Eudragit L-100, the drug dissolution rate obtained from Ex. 6 was less pH dependent. The drug release rate was faster in SIF during later hours of dissolution which is desirable for complete bioavailability.

EXAMPLES 7-8 As demonstrated in Fig. 5, with proper choice ofplasticizers, the drug release rate from the formula containing Eudragit L-100 can be reduced. This may be necessary to achieve desirable plasma drug concentration profiles after oral administration of the pellets.

EX. 7 TABLE 7 Composition Amt. (mg) p er Capsule Morphine Sulfate Eudragit RSPO 33.6 Eudragit L-100 8.4 Stearic Acid 9 Diethyl Phthalate 9 Total 120 EX. 8 TABLES8 Composition Amt. (mg) per Capsule Morphine Sulfate Eudragit RSPO 33.6 Eudragit L- 100 8.4 Stearic Acid 9 Tributyl Citrate 9 Total 120 a..

EXAMPLES 9-10 A different polymer/wax combination was used as an alternative formulation.

As seen in Figure 6, the drug dissolution rate from ethylcellulose/polyvinyl acetate phthalate was somewhat faster.

.4 EX. 9 TABLE9 Composition Amt. (mg) per Capsule Morphine-Sulfate Ethyl Cellulose 38.4 Polyvinyl Acetate Phthalate 3.6 Stearic Acid ]a Total 120 EX. 10 TABLE Composition Amt. (mg) per Capsule Morphine Sulfate Ethyl Cellulose 34,8 Polyvinyl Acetate Phthalate 72 Stearic Acid 18 Total 12.0 EXAMPLES 11-14 CONTROLLED RELEASE OXYCODOMI: FORM1.%IAIONS The formula used in Ex. 6 was applied to oxycodone hydrochloride. Due to the higher potency of oxycodone, only 20 mg of drug was used. The missing 40 mg was replaced by 40 mg of talc (Ex. 12). No replacement was used in Ex. 11. When tested in only SGF or SIF, the use of Eudragit L causes the formulation to become less pH dependent. The results are shown in Figure 7.

31 TABLE 11 Ingredients Amt(mg)/Capsule Percentage in Formula Oxycodone HCL 20 Eudragit RSPO 36 Eudragit L- 100 6 Stearic Acid 18 22.5 Total 80 100 The pellet manufacturing procedure and the dissolution method are the same as described in Example 6.

The above capsules were found to have the dissolution results set forth in Table I Ila below: 0 4.

09 C 9 0 9 9e*U 9. 0* 0 9 9 0*

C

0*@9

S

0~SS 9S* S .4 9.

.9

*OSC

Se S C 9.

*5 0 ,t 9*

S

eq 4@ 9e9 4 TABLE I Ia Time (hr) 1 2 4 8 12 18 24 Mean dissolved 14 29 45 66 81 94 101' EX. 12 TABLE 12 Cornposition Amt. (mg) per Capsule Oxycodone Hydrochloride Eudragit RSPO 36 Eudragit L- 100 6 Stearic Acid 18 Talc Total 120 .0

LD

4 4* .0 2 000 Ex. 13 Oxycodone HCI once-a-day capsules were produced with the following formula using the technology described in Example 6. The formulation is set forth in Table 13 below.

TABLE 13 Ingredients Amt(mg)/Capsule Percentage in Formula Oxycodone HCI 20 Eudragit RSPO 39 48.75 Eudragit L-100 3 3.75 Stearic Acid 18 22.5 Total 80 100 The pellet manufacturing procedure is the same as described in Example 6.

However, 80 mg of pellets were encapsulated to contain 20 mg of oxycodone HCL.

The above capsules were tested using the following dissolution methodology: I. Apparatus-USP type II (paddle), 100rpm at 37 C 2. Media- Either 900 ml simulated gastric fluid (SGF), pH 1.2 without enzyme.

or 900 ml simulated intestinal fluid (SIF), pH 7.5 without enzyme.

3. Analytical method- High performance liquid chromatography The dissolution results are set forth in Table 13a below: TABLE 13a Time (hr) 1 2 4 8 12 18 24 Mean dissolved (SGF) 13 20 29 41 51 62 71 Mean dissolved (SIF) 14 21 31 44 57 68 Ex. 14 To prepare an oxycodone HCI controlled release tablet which would dissolve preferentially in a lower pH, the following formula is used: TABLE 14 Ingredients Oxycodone HCI Eudragit RS30D (solid) Spray Dried Lactose

PVP

Triacetin Stearyl Alcohol Talc Magnesium Stearate Film Coat Amt(mg)/Tablet 40 14 35.25 5 2 25 2.5 1.25 5 130 Percentage in Formula 30.8 10.8 27.1 3.9 19.2 1.9 0.9 3.9 100 is: TnitaI Total Manufacture 1.

2.

3.

4.

6.

Mixer.

7.

congea 8.

Mix Eudragit RS30D (suspension) and Triacetin for 5 minutes.

Place spray dried lactose, oxycodone HCI, PVP, in a fluid bed drier.

Spray the suspension onto the powders under fluidization.

Pass the granulation through a Comil to reduce lumps.

Melt stearyl alcohol at Incorporate the molten stearyl alcohol into the dry granulation in a Collete Transfer the waxed granulation to a cooling tray and allow the granulation to 1.

Pass the granulation through a Comil.

9.

Mixer.

11.

Mix the waxed granulation with talc and magnesium stearate in a Collete Compress the lubricated granulation into tablets using a rotary tablet press.

Film coat the tablets.

These tablets were then tested using the following dissolution methodology described in Example 13.

The above tablets were found to have the following dissolution results: TABLE 14a Time (hr) 1 2 4 8 12 Mean dissolved SGF 39 53 70 90 99 Mean dissolved SIF 35 48 65 83 93 15 0 0 0 00 0 0 0.

EXAMPLES 15-19 CONTROLLED RELEASE HYDROMORPHONE FORMULATIONS Ex. 15-16 The formula used in Ex. 6 was applied to hydromorphone hydrochloride. Due to the higher potency of hydromorphone, only 8 mg of drug was used. The missing 52 mg was replaced by 52 mg of talc (Ex. 16) or 52 mg of excipients (Ex. 15). The results are shown in Figure 8.

EX. 15 TABLE Composition Amnt. (mg) per Capsule Hydromorphone Hydrochloride 8 Eudragit RSPO 67.2 Eudragit L-100 11.2 Stearic Acid 33.6 Total 120 EX. 16 TABLE 16 Composition Amit. (mg) per Capsule1 Hydromorphone Hydrochloride8 Eudragit RSPO 36 Eudragit L-100 6 Stearic Acid 18 Talc 52 ETotal 120 15 Ex. 17 1-ydromorphone HCI once-a-day capsules were produced with the formula set forth in Table 17 below using the technology described in Example 6.

TABLE 17 Ingredients Amt(rng)/Capsule Percentage in Formula Hydromorphone HCL 8 Eudragit RSPO 53 66.25 Stearyl Alcohol 19 23.75 Total 80 100 The pellet manufacturing procedure is the same as described in Example 6.

However, pellets of 1.0 mm in diameter and 1.0 mm in length were prepared. Each capsule holds 80 mg of pellets and contains 8 mg of hydromorphone HCL.

The above capsules were tested using the dissolution methodology described in Example 6.

The above capsules were found to have the dissolution results set forth in Table 17a below: TABLE 17a Time (hr) 1 2 4 8 12 18 24 Mean dissolved 17 28 32 45 56 69 82 Ex. 18 Hydromorphone HCI once-a-day capsules were produced with the formula set forth in Table 18 below as the second example of the technology described in Example 6.

TABLE 18 Ingredients Amt(mg)/Capsule Percentage in Formula Hydromorphone HCI 8 Eudragit RSPO 48 Stearyl Alcohol 24 Total 80 100 The pellet manufacturing procedure and the dissolution method are the same as described in Example 6.

The above capsules were found to have the dissolution results set forth in Table 18a below: TABLE 18a Time (hr) 1 2 4 8 12 18 24 Mean dissolved 23 29 40 56 69 84 96 a.

a a a..

Ex. 19 Hydromorphone HCI once-a-day capsules were produced with the following formula according to the method described Example 6.

TABLE 19 Ingredients Amt(mg)/Capsule Percentage in Formula Hydromorphone HCL 8 Eudragit RSPO 41.5 51.9 Eudragit L-100 8.5 10.6 Stearic Acid 22 27.5 Total 80 100 The manufacturing procedure of the pellets and the dissolution method are the same as described in Example 6.

The above capsules were found to have the following dissolution results: TABLE 19a Time (hr) 1 2 4 8 12 18 24 Mean dissolved 4 14 36 52 64 75 84 EXAMPLE In this Example, a bioavailability study was undertaken. Fourteen subjects were given the morphine sulfate formulations of Example 3. The results are provided in Table below in Figure TABLE Group AUC Cmax Tmax Example 3 Fasted 230 15.7 2.1 Example 3 Fed 213 14.0 3.2 From the above data, it can be seen that the formulation is an ideal candidate for an extended release or once-a-day product without a food effect.

EXAMPLE 21 Bioavailability of morphine sulfate melt extrusion multiparticulate 60 mg capsules.

A bioavailability study of morphine capsules of Example 6 was conducted in 12 normal male volunteers. Capsules of 60 mg in strength were administered either with 20 or without food in a single dose, two-way crossover study Blood samples were taken "periodically and assayed for morphine concentrations using gas chromatography with mass detection From the data, the following pharmacokinetic parameters were calculated and are indicated in Table 21 below.

TABLE 21 Treatment AUC, Cmax, n/ml Tmax, hr n. hr/ml Fasted 228 15.7 2.1 Fed 210 14.0 3.2 When compared to the typical blood levels of MS Contin®, a single dose twice-a-day marketed morphine sulfate 30 mg tablets, in the fasted state, it can be seen that the capsules of Example 6 are suitable for once daily administration. At the 24th hour the blood levels are well above MS-Contin and within the therapeutic range (Figure 11).

EXAMPLE 22 Bioavailability of OXY-MEM 20 mg capsules.

A bioavailability study of oxycodone capsules of examples 11 and 13 was conducted in 10 normal male volunteers. Capsules of example 13 were administered either with or without food. Capsules of example 11 were administered without food.

The study was conducted in a single dose, four-way crossover design. Blood samples were taken periodically and assayed for oxycodone concentrations using gas chromatography with mass detection (G/MS).

From the data, the following pharmacokinetic parameters were calculated as set forth in Table 22 below: TABLE 22 Treatment AUC, Cmax, n/ml Tmax, hr n. hr/mi Example 13, fasted 207 9.7 5.3 Example 13, fed 261 14.8 6.4 Example 11, fasted 244 12.9 Oxycontin, fasted 249 20.8 3.2 From the above data, it can be concluded that both Examples 11 and 13, but particularly Example 13, are suitable for once daily administration. This is shown graphically in Figure 12.

EXAMPLE 23 Bioavailability of Example 14 Tablets.

A bioavailability study of oxycodone controlled release tablets of example 14 was conducted in 25 normal volunteers. These tablets were administered either with or without food. The study was conducted in a single dose, randomized crossover design. Blood samples were taken periodically and assayed for oxycodone concentrations using gas chromatography with mass detection (GC/MS). The plasma oxycodone concentration versus time curves are shown in Figure 13.

From the data, the following pharmacokinetic parameters were calculated.

TABLE 23 Treatment AUC, ng.hr/ml Cmax, ng/ml Tmax, hr :15 Example 14, fasted 422 39.3 3.1 .Example 14, fed 416 35.3 4.8 Surprisingly, it was found that the controlled release oxycodone HCI Spreparation, which dissolved preferentially in low pH, does not show substantial food 20 effect. From the Cmax data, it can be seen that there is no significant change in blood oxycodone levels when the drug was taken with food than without food (35.3/39.3=.09). From the AUC (area under the curve) data, it appears that the amount of drug absorbed with or without food is similar (416/422=0.986).

EXAMPLE 24 Bioavailability of HH-MEM 8 mg capsules.

A bioavailability study of hydromorphone capsules of Examples 17 and 18 was conducted using a single dose, five-way crossover study in 12 normal male volunteers.

The subjects received either 8 mg of Dilaudid tablet (immediate release) or 8 mg of 41 HH-MEM capsules. Dilaudid tablets were administered after an overnight fast. MEM capsules were administered with or without food. Blood samples were taken periodically and assayed for hydromorphone concentrations using gas chromatography with mass detection From the data, the following pharmacokinetic parameters were calculated.

TABLE 24 ?2 0 Treatment AUC, Cmax, n/ml Tmax, hr n. hr/ml Example 17, fasted 19.23 0.76 3.9 Example 17, fed 21.47 0.93 1.9 Example 18, fasted 19.00 0.72 6.8 Example 18, fed 20.10 0.75 2.4 Dilaudid, fasted 14.55 3.69 0.7 From the above data, both formulations 17 and 18 would be suitable for oncea-day administration both not having a food effect, and in fact Example 17 looks ideal.

The data of Example 17 is shown graphically in Figure 14 and the data of Example 18 is shown graphically in Figure EXAMPLE Steady State Bioavailability of HH-MEM 8 mg capsules.

To assess steady state plasma levels and the effect of food on hydromorphone, a single dose, two-way crossover study was conducted in 12 normal male volunteers.

The subjects received either 4 mg of Dilaudid (immediate release) every 6 hours or 16 mg of the capsules according to Example 17 every 24 hours. Venous blood samples were taken at predetermined time points. The plasma hydromorphone concentrations were quantitated using gas chromatography with mass detection (G/MS).

From the data from day 4, the following pharmacokinetic parameters were calculated and are set forth in Table 25 below.

TABLE Treatment AUC, Cmax, Cmin, n/ml Tmax, hr n. hr/ml n/ml Example 16 36.08 2.15 1.49 5.8 Dilaudid 33.53 3.44 0.94 1.6 The results are shown graphically in Figure 16. From this data it can be seen that Example 17 is an ideal product for once-a-day administration for either single dose or multiple dose administration.

EXAMPLE 26 Bioavailability of HH-MEM 8 mg capsules.

a 6 6 0 6 6*

S

6**

S

6* 20 5*

S.

5 6* To assess bioavailability and effect of food on hydromorphone MEM capsules, a single dose, three-way crossover study was conducted in 12 normal male volunteers.

The subjects received either 8 mg of Dilaudid tablet (immediate release) or 8 mg of HH-MEM (Example 19.) Dilaudid tablets were administered after an overnight fast.

MEM capsules were administered with or without food. Venous blood samples were taken at predetermined at time points. The plasma hydromorphone concentrations were quantitated using gas chromatography with mass detection (G/MS).

From the data, the following pharmacokinetic parameters were calculated and are set forth in Table 26 below.

TABLE 26 Treatment AUC, Cmax, Tmax, hr n. hr/ml n/ml Example 18, fasted 15.83 0.52 5.6 Example 18, fed 16.55 0.65 4.1 Dilaudid, fasted 16.54 3.15 0.8 From the above data it can be concluded that a once-a-day Hydromorphone product can be produced using other ingredients than are used for Examples 17 and 18. This data is shown graphically in Figure 17.

EXAMPLE 27 Tramadol HC1200 mg SR Tablet The following formula is used to prepare melt extrusion granulation and tablet.

TABLE 27 Ingredients Amt(mg)/Tablet Percentage in Formula Tramadol HCI 200 53.4 SEudragit RSPO 74 19.8 *o Tributyl Citrate 14.8 Stearyl Alcohol 74 19.8 15 Talc 7.4 S, Magnesium Stearate 3.8 Total 374 100 Granulation Manufacture *see.: a. Extruder system description- The twin screw extruder is consisted of a pair of counterrotating screws and a barrel block equipped with heating/cooling zones. The stranded extrudate is congealed on a conveyor belt and cut into pellets of the desirable size.

b. Manufacturing procedure- 1 .Blend the drug and all the excipients in a proper mixer.

2.Place the mixture in a powder feeder.

3.Set temperatures of the extruder heating zones to approximately 65 "C.

4.Set the extruder screw rotation speed to 40 rpm.

Start the feeder and the conveyor.

6.After the excipients are melted and the drug embedded in the molten mixture, the viscous mass is extruded as spaghetti-like strands.

7.The extrudate is congealed and hardened while being carried away on a conveyor belt.

8.The stranded extrudate was cut into pellets of 2 mm in diameter and 2-8 cm in length.

Tabletting 00* The pellets were milled into granules through a suitable screen. The granulation was 15 blended with talc and magnesium stearate. The mixture was then compressed into capsule-shaped tablets.

fe Dissolution Method 1. Apparatus- USP Type II (paddle), 100 rpm at 37 0

C.

2. The tablet was placed in a tablet sinker clip and immersed in each vessel.

3. Media- 900 ml pH 6.5 phosphate buffer.

4. Analytical method- High performance liquid chromatography.

The above tablets were found to have the following dissolution results: TABLE 27a Time (hr) 1 2 4 8 12 18 24 Mean% 24 33 45 61 71 82 88 dissolved EXAMPLE 28 Tramadol HCI 200 mg SR Tablet The following formula is used to prepare melt extrusion granulation and tablet with a slower dissolution profile than example 27.

Ingredients Ingredients Tramadol HCI Ethyl cellulose Tributyl Citrate Stearyl Alcohol Talc Magnesium Stearate Total TABLE 28 Amt(mg)/Tablet Percentage in Formula 200 44.1 110 24.3 22 4.9 110 24.3 7.4 1.6 3.8 0.8 453.2 100 20 The manufacturing procedure and dissolution method are the same as described in example 27. Additional dissolution media used include pH 1.2 simulated gastric fluid (SGF) without enzyme, pH 7.5 simulated intestinal fluid (SIF) without enzyme, and pH 4 phosphate buffer.

The above tablets were found to have the following dissolution results: TABLE 28a Time (hr) 1 2 4 8 12 18 24 Mean dissolved SGF 18 26 35 49 59 70 pH4 17 25 34 49 60 73 83 17 23 33 46 57 70 81 SIF 17 23 32 45 56 68 78 The results show that the dissolution profiles of Tramadol SR tablets in media of different pH values are similar. Based on our experience with similar formulae of other opiates, a formula which demonstrates pH independent dissolution profile would provide a consistent drug release profile in vivo without food effect.

The examples provided above are not meant to be exclusive. Many other variations of the present invention would be obvious to those skilled in the art, and are contemplated to be within the scope of the appended claims.

o.

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Claims (55)

1. A unit dose sustained-release oral dosage form comprising a plurality of extruded particles, each of said particles consisting essentially of: an opioid analgesic dispersed in a matrix comprising one or more hydrophobic materials; and a retardant; said particles being non-spheroidal and having a length from about 0.1mm to about 12mm and a diameter from about O.1mm to about 5mm, said unit dose providing a release of said opioid analgesic over from about 8 to about 24 hours, said particles being formed by mixing the opioid analgesic, the one or more hydrophobic materials, and the retardant in an extruder to form said matrix, extruding the matrix in the extruder to form strands, and cutting said strands into said extruded particles. o: 2. A sustained-release particle comprising: an active agent selected from the group consisting of disinfecting agents, chemical impregnants, cleansing agents, deodorants, fragrances, dyes, animal repellents, insect repellents, 15 fertilizing agents, pesticides, herbicides, fungicides and plant growth stimulants dispersed in a matrix comprising: at least one hydrophobic material; and *a retardant selected from the group consisting of fatty alcohols, hydrogenated fats, fatty acid glycerides, hydrocarbons, waxes, hydrophobic and hydrophilic polymers having hydrocarbon S 20 backbones, fatty acid esters and mixtures thereof; oo said particle being non-spheroidal and having a length from about 0.1mm to about 12mm and a 0 g0diameter from about O.1mm to about 5mm and providing sustained release of said active agent, said particle being formed by mixing the active agent, the at least one hydrophobic material, and the retardant in an extruder to form said matrix, extruding the matrix in the extruder to form strands, and cutting said strands into said extruded particles.

3. A sustained-release formulation comprising: a plurality of extruded particles, each of said particles comprising an opioid analgesic dispersed in a matrix comprising: one or more hydrophobic materials selected from the group consisting of ethylcellulose and acrylic polymers; and a retardant selected from the group consisting of fatty alcohols, hydrogenated fats, fatty acid glycerides, hydrocarbons, waxes, hydrophobic and hydrophilic polymers having hydrocarbon backbones, fatty acid esters and mixtures thereof; said particles being non-spheroidal and having a length from about 0.1mm to about 12mm and /j3 a iameter from about O.1mm to about 5mm and providing sustained release of the opioid analgesic [R:\LIBA]4691 .doc:mef 48 over from about 8 hours to about 24 hours, said particles being formed by mixing the opioid analgesic, the one or more hydrophobic materials, and the retardant in an extruder to form said matrix, extruding the matrix in the extruder to form strands, and cutting said strands into said extruded particles.

4. The unit dose of claim 1, wherein said opioid analgesic is selected from the group consisting of alfentanil, allylprodine, alphaprodine, anileridine, benzylmorphine, bezitramide, burprenophine, butorphanol, clonitazene, codeine, desomorphine, destromoramide, dezocine, diampromide, dihydrocodeine, dihydromorphine, dimenoxadol, dimepheptanol, dimethylthiambutene, dioxaphetyl butyrate, dipipanone, eptazocine, ethoheptazine, ethylmethylthiambutene, ethylmorphine, etonitazene, fentanyl, heroin, hydrocodone, hydromorphone, hydroxypethidine, isomethadone, ketobemidone, levallorphan, levorphanol, levophenacyl morphan, lofentanil, meperidine, meptazinol, metazocine, methadone, metophon, morphine, myrophine, nalbuphine, narceine, nicomorphine, norlevorphanol, normethadone, nalorphine, normorphine, norpipanone, opium, oxycodone, oxymorphone, papaveretum, pentazocine, phenadoxone, phenomorphan, phenazocine, phenoperidine, piminodine, piritramide, proheptazoine, promedol, properidine, propiram, propoxyphene, sufentanil, tramadol, tilidine, salts thereof and mixtures thereof.

5. The unit dose of claim 1, wherein said opioid analgesic consists of from about 2mg to about 64mg hydromorphone.

6. The unit dose of claiml, wherein said opioid analgesic consists of from about 5mg to about 800mg morphine. 20 7. The unit dose of claim 1, wherein said opioid analgesic consists of from about 5mg to about 400mg oxycodone.

8. The unit dose of claim 1, wherein said hydrophobic material is selected from the group consisting of acrylic polymers, hydroxyalkylcelluloses and mixtures thereof.

9. The unit dose of claim 8, wherein said acrylic polymer is comprised of monomers selected from the group consisting of an ester of acrylic acid, an ester of methacrylic acid, an alkyl ester of acrylic acid, an alkyl ester of methacrylic acid, and mixtures of any of the foregoing. The unit dose of claim 1, wherein said retardant is selected from the group consisting of fatty alcohols, hydrogenated fats, fatty acid esters, fatty acid glycerides, hydrocarbons, waxes, stearic acid, stearyl alcohol, and hydrophobic and hydrophilic polymers having hydrocarbon backbones, and mixtures thereof.

11. The unit dose of claim 1, wherein said retardant is selected from the group consisting of stearyl alcohol, stearic acid, water-insoluble waxes, and mixtures thereof.

12. A unit dose comprising: Sa gelatin capsule containing a plurality of extruded particles, each of said particles comprising apioid analgesic dispersed in a matrix comprising: [R:\LIBA]4691.doc:mef one or more hydrophobic materials selected from the group consisting of ethylcellulose, acrylic polymers and mixtures thereof; a retardant selected from the group consisting of stearic acid; and a hydroxyalkycellulose; said particles being non-spheroidal and having a length from about 0.1mm to about 12mm and a diameter from about 0.1mm to about 5mm, said formulation providing sustained release of the opioid analgesic over from about 8 hours to about 24 hours, said particles being formed by mixing the opioid analgesic, the one or more hydrophobic materials, and the retardant in an extruder to form said matrix, extruding the matrix in the extruder to form strands, and cutting said strands into said extruded particles.

13. The unit dose of claim 1, wherein each of said particles comprise from about 1% to about 99% of said one or more hydrophobic materials.

14. The unit dose of claim 1, wherein each of said particles comprise from about 5% to about of said one or more hydrophobic materials. is 15. A method of preparing a multiparticulate sustained release oral dosage form, comprising the steps of: feeding, in powder form, a therapeutically active agent, and a hydrophobic material into an extruder; mixing together the therapeutically active agent and the hydrophobic material in the i 20 extruder to obtain a homogeneous mixture; heating said homogeneous mixture in the extruder; extruding said homogeneous mixture with the extruder to thereby form strands; cooling said strands containing said homogeneous mixture; cutting said strands into generally cylindrically-shaped particles having a length from about 0.1 mm to about 12mm and a diameter of from about 0.1 mm to about 5mm; and dividing said generally cylindrically-shaped particles into unit doses, the ratio of said hydrophobic material to said therapeutically active agent in said mixture being sufficient to impart a release of said therapeutically active agent from said particles over a time period of from about 8 hours to about 24 hours when said particles are exposed to an aqueous fluid.

16. The method of claim 15, wherein said unit doses and placed into gelatin capsules.

17. The method of claim 15, wherein said homogeneous mixture is heated to a temperature from about 30 degree C to about 200 degree C prior to extrusion.

18. A method of treating a patient with a sustained release multiparticulate formulation of a ,therapeutically active agent, comprising the steps of: [R:\LIBA]4691 .doc:mef feeding in powder form, a therapeutically active agent, and a hydrophobic material into an extruder; mixing together the therapeutically active agent and the hydrophobic material in the extruder to obtain a homogeneous mixture; heating said homogeneous mixture in the extruder; extruding said homogeneous mixture with the extruder to thereby form strands; cooling said strands containing said homogeneous mixture; cutting said strands into generally cylindrically-shaped particles having a length of from about 0.1mm to about 12mm and a diameter of from about 0.1mm to about 3mm; dividing said generally cylindrically-shaped particles into unit doses; and administering said unit dose to a patient, the ratio of said hydrophobic material to said therapeutically active agent in said mixture being sufficient to impart a release of said therapeutically active agent from said particles over a time period of at least about 6 hours when said unit dose is administered to said patient. 15 s19. The method of claim 15, wherein said therapeutically active agent is an opioid analgesic *0 selected from the group consisting of morphine, codeine, hydromorphone, hydrocodone, oxycodone, oxymorphone, dihydrocodeine, dihydromorphine, tramadol, salts thereof, and mixtures thereof.

20. The method of claim 15 wherein said therapeutically active agent is an opioid analgesic selected from the group consisting of opioid analgesic is selected from the group consisting of S 20 alfentanil, allylprodine, alphaprodine, anileridine, benzylmorphine, bezitramide, buprenophine, butorphanol, clonitazene, codeine, desomorphine, destromoramide, dezocine, diampromide, dihydrocodeine, dihydromorphine, dimenoxadol, dimepheptanol, dimethylthiambutene, dioxaphetyl butyrate, dipipanone, eptazocine, ethoheptazine, ethylmethylthiambutene, ethylmorphine, etonitazene, fentanyl, heroin, hydrocodone, hydromorphone, hydroxypethidine, isomethadone, ketobemidone, levallorphan, levorphanol, levophenacyl morphan, lofentanil, meperidine, meptazinol, metazocine, methadone, metophon, morphine, myrophine, nalbuphine, narceine, nicomorphine, norlevorphanol, normethadone, nalorphine, normorphine, norpipanone, opium, oxycodone, oxymorphone, papaveretum, pentazocine, phenadoxone, phenomorphan, phenazocine, phenoperidine, piminodine, piritramide, proheptazoine, promedol, properidine, propiram, propoxyphene, sufentanil, tramadol, tilidine, salts thereof and mixtures thereof.

21. The method of claim 15, wherein said therapeutically active agent consists of from about 2mg to about 64mg hydromorphone.

22. The method of claim 15, wherein said therapeutically active agent consists of from about 5mg to about 800mg morphine. [R:\LIBA]4691.doc:mef 51

23. The method of claim 15, wherein said therapeutically active agent consists of from about to about 400mg oxycodone.

24. The method of claim 15, wherein said hydrophobic material is selected from the group consisting of acrylic polymers, hydroxyalkylcelluloses and mixtures thereof.

25. The method of claim 15, wherein said hydrophobic material is comprised of monomers selected from the group consisting of an ester of acrylic acid, an ester of methacrylic acid, an alkyl ester of acrylic acid, an alkyl ester of methacrylic acid, and mixtures of any of the foregoing.

26. The method of claim 15, wherein step further includes feeding a retardant into the extruder, and wherein step further includes mixing the retardant with the therapeutically active agent, and the hydrophobic material to obtain the homogeneous mixture, and wherein said retardant is water insoluble and is selected from the group consisting of fatty alcohols, hydrogenated fats, stearic acid, stearyl alcohol, fatty acid glycerides, hydrocarbons, waxes, hydrophobic and hydrophilic polymers having hydrocarbon backbones, fatty acid esters, and mixtures thereof.

27. A method of preparing a multiparticulate sustained release oral dosage form, comprising S 15 the steps of: directly metering into an extruder a hydrophobic material and a therapeutically active agent to obtain a homogeneous mixture; heating said homogeneous mixture; extruding said homogeneous mixture to thereby form strands; 20 cooling said strands containing said homogeneous mixture; cutting said strands into generally cylindrically-shaped particles having a length of from about 0.1mm to about 12mm and a diameter of from about 0.1mm to about 3mm; and dividing said generally cylindrically-shaped particles into unit doses.

28. An opioid unit dose sustained-release oral dosage form having substantially no feeding- fasting effect, comprising a plurality of extruded particles, each of said particles comprising a matrix consisting essentially of: an opioid analgesic; one or more hydrophobic materials; said particles having a length from about 0.1 mm to about 12mm and a diameter of from about 0. 1mm to about 3mm, said unit dose providing a release of said opioid analgesic over at least about 12-24 hours, said particles being formed by mixing the opioid analgesic, the one or more hydrophobic materials, an optional retardant, and optional excipients in an extruder to form said matrix, extruding the matrix in the extruder to form strands, and cutting said strands into said extruded particles.

29. A sustained release unit dose formulation comprising the particles prepared according to 3 the method of claim [R:\LIBA]4691.doc:mef 52 The method according to claim 27, wherein step further includes directly metering a retardant into the extruder.

31. The method according to claim 27, wherein step further includes directly metering a pharmaceutical excipient into the extruder.

32. The unit dose of claim 10 wherein said hydrogenated fats are selected from the group consisting of hydrogenated vegetable oil and hydrogenated castor oil; and wherein said waxes are water-insoluble.

33. The unit dose of claim 1, wherein said one or more hydrophobic materials is an acrylic polymer.

34. The unit dose of claim 1, wherein said one or more hydrophobic materials is an hydroxyalkylcellulose.

35. The unit dose of claim 32, wherein said water-insoluble wax is paraffin. oo

36. The method of claim 26, wherein said hydrogenated fats are selected from the group consisting of hydrogenated vegetable oil and hydrogenated castor oil; and wherein said waxes are :1 *water-insoluble.

37. The dosage form of claim 28, wherein said one or more hydrophobic materials is an acrylic polymer.

38. The dosage form of claim 28, wherein said one or more hydrophobic materials is an 0 hydroxyalkylcellulose. 2 39. The method of claim 15, further comprising the step of formulating said unit doses into tablets. :40. The method of claim 36, wherein said water-insoluble wax is paraffin.

41. The unit dose of claim 1, wherein said retardant is stearic acid.

42. The unit dose of claim 41, wherein said one or more hydrophobic materials is ethylcellulose.

43. The unit dose of claim 1, wherein said therapeutically active agent is tramadol.

44. The unit dose of claim 42, wherein said opioid analgesic is selected from the group consisting of hydromorphone, oxycodone, morphine, tramadol, salts thereof and mixtures thereof. The unit dose of claim 1, wherein said retardant is selected from the group consisting of stearic acid, stearyl alcohol, and mixtures thereof.

46. The unit dose of claim 1 wherein said opioid analgesic, said one or more hydrophobic materials and said retardant are mixed together to obtain a homogeneous mixture.

47. The unit dose of claim 46, wherein said mixture is heated to a temperature sufficient to t said mixture but below the temperature required to melt said one or more hydrophobic materials. r/ "'35 48. The unit dose of claim 46, wherein said mixture further comprises a plasticizer. [R:\LIBA]4691 .doc:mef

49. The unit dose of claim 48, wherein said one or more hydrophobic materials is selected from the group consisting of ethylcellulose, acrylic polymers, and mixtures thereof. The unit dose of claim 49, wherein said mixture is heated to a temperature of from 85 to 105 degree C.

51. The unit dose of claim 50, wherein said plasticizer is selected from the group consisting of diethyl phthalate, tributyl citrate and polyvinyl acetate phthalate.

52. The method of claim 15, wherein said hydrophobic material is ethylcellulose.

53. The method of claim 26, wherein said retardant is stearic acid.

54. The method of claim 15, wherein said active agent is tramadol.

55. The sustained-release particle of claim 2, wherein said hydrogenated fats are selected from the group consisting of hydrogenated vegetable oil and hydrogenated castor oil; and wherein S. said wax is paraffin. S.56. The sustained-release formulation of claim 3, wherein said hydrogenated fats are selected from the group consisting of hydrogenated vegetable oil and hydrogenated castor oil; and 15 wherein said wax is paraffin.

57. The sustained release formulation of claim 28, wherein said opioid analgesic is selected from the group consisting of morphine, tramadol, oxycodone, hydromorphone, hydrocodone, oxymorphone, dihydrocodeine, dihydromorphine, salts thereof and mixtures thereof.

58. The oral dosage form of claim 28, further comprising a retardant. 20 59. The oral dosage form of claim 58, further comprising a pharmaceutical excipient.

60. The unit dose of claim 4, wherein said opioid analgesic is selected from the group consisting of morphine, codeine, hydromorphone, hydrocodone, oxycodone, oxymorphone, dihydrocodeine, dihydromorphine, tramadol, salts thereof and mixtures thereof.

61. The method according to claim 15, wherein step further includes feeding a retardant into the extruder, and wherein step further includes mixing the retardant with the therapeutically active agent, and the hydrophobic material to obtain the homogeneous mixture.

62. The method according to claim 61, wherein, prior to step the therapeutically active agent and the retardant are mixed together.

63. The method according to claim 61, wherein, prior to step the therapeutically active agent, the hydrophobic material and the retardant are mixed together.

64. The method according to claim 18, wherein step further includes feeding a retardant into the extruder, and wherein step further includes mixing the retardant with the therapeutically active agent, and the hydrophobic material to obtain the homogeneous mixture. The method according to claim 64, wherein, prior to step the therapeutically active t and the retardant are mixed together. [R:\LIBA]4691 .doc:mef 54

66. The method according to claim 65, wherein, prior to step the therapeutically active agent, the hydrophobic material and the retardant are mixed together.

67. A unit dose sustained-release oral dosage form comprising a plurality of extruded particles, substantially as hereinbefore described with reference to any one of the examples.

68. A sustained release formulation comprising a plurality of extruded particles, substantially as hereinbefore described with reference to any one of the examples.

69. A method of preparing a multiparticulate sustained release oral dosage form substantially as hereinbefore described with reference to any one of Examples 1-6, 11-14, 15-19 and 27-28. Dated 27 February, 2002 Euro-Celtique, S.A. Patent Attorneys for the Applicant/Nominated Person SPRUSON FERGUSON o e *ooo So *6 [R:\LIBA]4691.doc:mef