AU740447B2 - Thrombin inhibitors - Google Patents

Thrombin inhibitors Download PDF

Info

Publication number
AU740447B2
AU740447B2 AU93973/98A AU9397398A AU740447B2 AU 740447 B2 AU740447 B2 AU 740447B2 AU 93973/98 A AU93973/98 A AU 93973/98A AU 9397398 A AU9397398 A AU 9397398A AU 740447 B2 AU740447 B2 AU 740447B2
Authority
AU
Australia
Prior art keywords
mammal
compound
pharmaceutically acceptable
composition
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU93973/98A
Other languages
English (en)
Other versions
AU9397398A (en
Inventor
Craig Coburn
Joseph P. Vacca
Peter D. Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9807941.1A external-priority patent/GB9807941D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU9397398A publication Critical patent/AU9397398A/en
Application granted granted Critical
Publication of AU740447B2 publication Critical patent/AU740447B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU93973/98A 1997-09-23 1998-09-18 Thrombin inhibitors Ceased AU740447B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5980197P 1997-09-23 1997-09-23
US60/059801 1997-09-23
GB9807941 1998-04-15
GBGB9807941.1A GB9807941D0 (en) 1998-04-15 1998-04-15 Thrombin inhibitors
PCT/US1998/019471 WO1999015169A1 (en) 1997-09-23 1998-09-18 Thrombin inhibitors

Publications (2)

Publication Number Publication Date
AU9397398A AU9397398A (en) 1999-04-12
AU740447B2 true AU740447B2 (en) 2001-11-01

Family

ID=26313472

Family Applications (1)

Application Number Title Priority Date Filing Date
AU93973/98A Ceased AU740447B2 (en) 1997-09-23 1998-09-18 Thrombin inhibitors

Country Status (5)

Country Link
EP (1) EP1017383A4 (de)
JP (1) JP2001517623A (de)
AU (1) AU740447B2 (de)
CA (1) CA2301614A1 (de)
WO (1) WO1999015169A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
JP2003501389A (ja) * 1999-06-04 2003-01-14 メルク エンド カムパニー インコーポレーテッド トロンビン阻害物質
FR2795072B1 (fr) * 1999-06-15 2001-07-27 Adir Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
SI3762368T1 (sl) 2018-03-08 2022-06-30 Incyte Corporation Aminopirazin diolne spojine kot zaviralci PI3K-y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW263498B (de) * 1993-11-10 1995-11-21 Takeda Pharm Industry Co Ltd
SK83897A3 (en) * 1994-12-22 1998-05-06 Iaf Biochem Int Low molecular weight bicyclic thrombin inhibitors

Also Published As

Publication number Publication date
EP1017383A4 (de) 2001-11-28
CA2301614A1 (en) 1999-04-01
EP1017383A1 (de) 2000-07-12
WO1999015169A1 (en) 1999-04-01
JP2001517623A (ja) 2001-10-09
AU9397398A (en) 1999-04-12

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)