AU7130101A - Enzyme-cleavable prodrug compounds - Google Patents

Enzyme-cleavable prodrug compounds

Info

Publication number
AU7130101A
AU7130101A AU7130101A AU7130101A AU7130101A AU 7130101 A AU7130101 A AU 7130101A AU 7130101 A AU7130101 A AU 7130101A AU 7130101 A AU7130101 A AU 7130101A AU 7130101 A AU7130101 A AU 7130101A
Authority
AU
Australia
Prior art keywords
enzyme
prodrug compounds
cleavable prodrug
cleavable
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU7130101A
Inventor
Matthew H Nieder
Vincent Dubois
Sanjeev Gangwar
Thomas J Lobl
Leslie B Pickford
Andre Trouet
Geoffrey T Yarranton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corixa Corp
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corixa Corp filed Critical Corixa Corp
Publication of AU7130101A publication Critical patent/AU7130101A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU7130101A 2000-06-14 2001-06-11 Enzyme-cleavable prodrug compounds Pending AU7130101A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21188700P 2000-06-14 2000-06-14
US29044801P 2001-05-11 2001-05-11
PCT/US2001/018903 WO2001095945A2 (en) 2000-06-14 2001-06-11 Prodrug compounds cleavable by thimet oligopeptidase

Publications (1)

Publication Number Publication Date
AU7130101A true AU7130101A (en) 2001-12-24

Family

ID=26906558

Family Applications (2)

Application Number Title Priority Date Filing Date
AU7130101A Pending AU7130101A (en) 2000-06-14 2001-06-11 Enzyme-cleavable prodrug compounds
AU2001271301A Ceased AU2001271301B2 (en) 2000-06-14 2001-06-11 Prodrug compounds cleavable by thimet oligopeptidase

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2001271301A Ceased AU2001271301B2 (en) 2000-06-14 2001-06-11 Prodrug compounds cleavable by thimet oligopeptidase

Country Status (5)

Country Link
EP (1) EP1294405A2 (en)
JP (1) JP2004510703A (en)
AU (2) AU7130101A (en)
CA (1) CA2411660C (en)
WO (1) WO2001095945A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03011094A (en) 2001-05-31 2004-12-06 Medarex Inc Cytotoxins, prodrugs, linkers and stabilizers useful therefor.
ES2364452T3 (en) 2001-06-11 2011-09-02 Medarex, Inc. METHOD FOR DESIGNING PROFESSIONAL COMPOUNDS ACTIVATED BY CD10.
FR2858936A1 (en) * 2003-08-22 2005-02-25 Diatos New active compound precursor, useful as therapeutic or diagnostic agent or tracer, includes cleavable component that increases half-life in the circulation, attached through hydrophilic spacer
CN101626782B (en) 2006-12-01 2013-03-27 梅达雷克斯公司 Human antibodies that bind cd22 and uses thereof
CL2007003622A1 (en) 2006-12-13 2009-08-07 Medarex Inc Human anti-cd19 monoclonal antibody; composition comprising it; and tumor cell growth inhibition method.
AU2007333098A1 (en) 2006-12-14 2008-06-19 Medarex, Inc. Human antibodies that bind CD70 and uses thereof
US9662308B2 (en) 2008-02-01 2017-05-30 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg Orally bioavailable pentamidine prodrugs for the treatment of diseases
DE102008007381A1 (en) * 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Amidines and guanidines and their derivatives for the treatment of diseases
SG11201506804VA (en) 2013-03-21 2015-09-29 Sanofi Aventis Deutschland Synthesis of hydantoin containing peptide products
WO2014147129A1 (en) 2013-03-21 2014-09-25 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
AU2021405744A1 (en) 2020-12-22 2023-08-03 Cobiores Nv Compounds comprising a tetrapeptidic moiety
WO2022167664A1 (en) 2021-02-07 2022-08-11 Cobiores Nv Compounds comprising a tetrapeptidic moiety

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT769967E (en) * 1994-08-19 2008-02-18 Univ Catholique Louvain Conjugates comprising an antitumour agent and their use
NZ512171A (en) * 1998-12-11 2004-07-30 Medarex Inc Prodrug compound comprising a therapeutic agent, an oligopeptide with a non-genetically encoded amino acid, a stabilizing group and optionally a linker group

Also Published As

Publication number Publication date
AU2001271301B2 (en) 2006-08-31
CA2411660A1 (en) 2001-12-20
WO2001095945A3 (en) 2002-08-15
WO2001095945A2 (en) 2001-12-20
CA2411660C (en) 2011-03-01
EP1294405A2 (en) 2003-03-26
JP2004510703A (en) 2004-04-08

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