AU691226B2 - Amphiphilic derivatives of guanidine - Google Patents
Amphiphilic derivatives of guanidine Download PDFInfo
- Publication number
- AU691226B2 AU691226B2 AU11842/95A AU1184295A AU691226B2 AU 691226 B2 AU691226 B2 AU 691226B2 AU 11842/95 A AU11842/95 A AU 11842/95A AU 1184295 A AU1184295 A AU 1184295A AU 691226 B2 AU691226 B2 AU 691226B2
- Authority
- AU
- Australia
- Prior art keywords
- amphiphile
- lipid
- document
- date
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15772793A | 1993-11-24 | 1993-11-24 | |
US157727 | 1993-11-24 | ||
US24800594A | 1994-05-24 | 1994-05-24 | |
US248005 | 1994-05-24 | ||
PCT/US1994/013428 WO1995014381A1 (en) | 1993-11-24 | 1994-11-17 | Amphiphilic derivatives of guanidine |
Publications (2)
Publication Number | Publication Date |
---|---|
AU1184295A AU1184295A (en) | 1995-06-13 |
AU691226B2 true AU691226B2 (en) | 1998-05-14 |
Family
ID=26854424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU11842/95A Ceased AU691226B2 (en) | 1993-11-24 | 1994-11-17 | Amphiphilic derivatives of guanidine |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0730405A4 (no) |
JP (1) | JPH09505808A (no) |
KR (1) | KR960705771A (no) |
AU (1) | AU691226B2 (no) |
CA (1) | CA2176715A1 (no) |
NO (1) | NO962074L (no) |
NZ (1) | NZ276975A (no) |
WO (1) | WO1995014381A1 (no) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5910487A (en) * | 1994-12-09 | 1999-06-08 | Genzyme Corporation | Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules |
US6331524B1 (en) | 1994-12-09 | 2001-12-18 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile / DNA complexes for gene therapy |
US5719131A (en) * | 1994-12-09 | 1998-02-17 | Genzyme Corporation | Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules |
US5650096A (en) * | 1994-12-09 | 1997-07-22 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5747471A (en) * | 1994-12-09 | 1998-05-05 | Genzyme Corporation | Cationic amphiphiles containing steroid lipophilic groups for intracellular delivery of therapeutic molecules |
US5840710A (en) * | 1994-12-09 | 1998-11-24 | Genzyme Corporation | Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules |
US5767099A (en) * | 1994-12-09 | 1998-06-16 | Genzyme Corporation | Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules |
US6383814B1 (en) | 1994-12-09 | 2002-05-07 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5948767A (en) * | 1994-12-09 | 1999-09-07 | Genzyme Corporation | Cationic amphiphile/DNA complexes |
US5830878A (en) | 1995-06-07 | 1998-11-03 | Megabios Corporation | Cationic lipid: DNA complexes for gene targeting |
WO1997019675A2 (en) | 1995-11-30 | 1997-06-05 | Vical Incorporated | Complex cationic lipids |
SE9504347D0 (sv) * | 1995-12-01 | 1995-12-01 | Boerje Sellergren | Surface modification technique |
EP0779361A3 (en) | 1995-12-15 | 1999-11-10 | F. Hoffmann-La Roche Ag | Truncated form of inhibitory kappa B protein (1kB), recombinant production and uses thereof |
US6143729A (en) * | 1996-03-01 | 2000-11-07 | Aventis Pharma S.A. | Compounds related to the amidinium family, pharmaceutical compositions containing same, and uses thereof |
US5935936A (en) * | 1996-06-03 | 1999-08-10 | Genzyme Corporation | Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules |
US5861397A (en) * | 1996-10-03 | 1999-01-19 | Vical Incorporated | Piperazine based cytofectins |
CA2217550A1 (en) * | 1996-10-22 | 1998-04-22 | F. Hoffmann-La Roche Ag | Cationic lipids for gene therapy |
US5925628A (en) * | 1997-03-31 | 1999-07-20 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5958894A (en) * | 1997-04-04 | 1999-09-28 | Megabios Corporation | Amphiphilic biguanide derivatives |
US6235310B1 (en) | 1997-04-04 | 2001-05-22 | Valentis, Inc. | Methods of delivery using cationic lipids and helper lipids |
US5912239A (en) * | 1997-04-04 | 1999-06-15 | Genzyme Corporation | Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5948925A (en) * | 1997-05-06 | 1999-09-07 | Genzyme Corporation | Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids |
US5952516A (en) * | 1997-05-08 | 1999-09-14 | Genzyme Corporation | Cationic amphiphiles containing multiplesteroid lipophilic groups |
US5942634A (en) * | 1997-05-09 | 1999-08-24 | Genzyme Corporation | Cationic amphiphiles for cell transfections |
FR2763943B1 (fr) * | 1997-05-28 | 1999-07-09 | Rhone Poulenc Rorer Sa | Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules |
CA2309766C (en) | 1997-11-20 | 2008-09-30 | Vical Incorporated | Treatment of cancer using cytokine-expressing polynucleotides and compositions therefor |
GB0413613D0 (en) * | 2004-06-17 | 2004-07-21 | Univ London | Small molecule carriers |
CA2916898A1 (en) | 2013-07-16 | 2015-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of osteogenic potential of bone grafts |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
-
1994
- 1994-11-17 AU AU11842/95A patent/AU691226B2/en not_active Ceased
- 1994-11-17 CA CA002176715A patent/CA2176715A1/en not_active Abandoned
- 1994-11-17 WO PCT/US1994/013428 patent/WO1995014381A1/en not_active Application Discontinuation
- 1994-11-17 JP JP7515172A patent/JPH09505808A/ja active Pending
- 1994-11-17 EP EP95902642A patent/EP0730405A4/en not_active Ceased
- 1994-11-17 KR KR1019960702743A patent/KR960705771A/ko not_active Application Discontinuation
- 1994-11-17 NZ NZ276975A patent/NZ276975A/en unknown
-
1996
- 1996-05-21 NO NO962074A patent/NO962074L/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO962074L (no) | 1996-07-11 |
NO962074D0 (no) | 1996-05-21 |
EP0730405A4 (en) | 1997-02-19 |
KR960705771A (ko) | 1996-11-08 |
WO1995014381A1 (en) | 1995-06-01 |
NZ276975A (en) | 1998-04-27 |
JPH09505808A (ja) | 1997-06-10 |
CA2176715A1 (en) | 1995-06-01 |
AU1184295A (en) | 1995-06-13 |
EP0730405A1 (en) | 1996-09-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |