AU676826B2 - Transdermal therapeutic systems - Google Patents

Transdermal therapeutic systems

Info

Publication number
AU676826B2
AU676826B2 AU22298/92A AU2229892A AU676826B2 AU 676826 B2 AU676826 B2 AU 676826B2 AU 22298/92 A AU22298/92 A AU 22298/92A AU 2229892 A AU2229892 A AU 2229892A AU 676826 B2 AU676826 B2 AU 676826B2
Authority
AU
Australia
Prior art keywords
transdermal therapeutic
therapeutic systems
penetration enhancer
polar penetration
polar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU22298/92A
Other versions
AU2229892A (en
Inventor
Matthias Hartisch
Ralph Lipp
Jutta Riedl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU2229892A publication Critical patent/AU2229892A/en
Application granted granted Critical
Publication of AU676826B2 publication Critical patent/AU676826B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Described are transdermal therapeutic systems characterized in that they contain, in an adhesive matrix containing an active substance, a polar penetration enhancer and a non-polar penetration enhancer which is insoluble in the polar penetration enhancer.
AU22298/92A 1991-07-30 1992-07-07 Transdermal therapeutic systems Ceased AU676826B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE4125611 1991-07-30
DE4125611 1991-07-30
DE4210165A DE4210165A1 (en) 1991-07-30 1992-03-25 TRANSDERMAL THERAPEUTIC SYSTEMS
DE4210165 1992-03-25
PCT/EP1992/001515 WO1993002669A1 (en) 1991-07-30 1992-07-07 Transdermal therapeutic systems

Publications (2)

Publication Number Publication Date
AU2229892A AU2229892A (en) 1993-03-02
AU676826B2 true AU676826B2 (en) 1997-03-27

Family

ID=25906037

Family Applications (1)

Application Number Title Priority Date Filing Date
AU22298/92A Ceased AU676826B2 (en) 1991-07-30 1992-07-07 Transdermal therapeutic systems

Country Status (14)

Country Link
EP (1) EP0596903B1 (en)
JP (1) JPH06509346A (en)
AT (1) ATE151985T1 (en)
AU (1) AU676826B2 (en)
CA (1) CA2114537A1 (en)
DE (2) DE4210165A1 (en)
DK (1) DK0596903T3 (en)
ES (1) ES2103952T3 (en)
FI (1) FI940427A (en)
GR (1) GR3024097T3 (en)
HU (1) HU217215B (en)
NO (1) NO307736B1 (en)
PT (1) PT100737B (en)
WO (1) WO1993002669A1 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE184473T1 (en) * 1992-06-11 1999-10-15 Theratech Inc USE OF GLYCERINE TO ATTENUATE TRANSDERMAL DRUG ADMINISTRATION
US5843979A (en) * 1993-02-25 1998-12-01 Bristol-Myers Squibb Company Transdermal treatment with mast cell degranulating agents for drug-induced hypersensitivity
US5460820B1 (en) † 1993-08-03 1999-08-03 Theratech Inc Method for providing testosterone and optionally estrogen replacement therapy to women
DE4332094C2 (en) * 1993-09-22 1995-09-07 Lohmann Therapie Syst Lts Active substance plaster which can be produced without solvent and process for its preparation
DE4405899A1 (en) * 1994-02-18 1995-08-24 Schering Ag Agent for transdermal application containing desogestrel
DE4429667C2 (en) * 1994-08-20 1996-07-11 Lohmann Therapie Syst Lts Estradiol TTS with water-binding additives and process for its preparation
JP4024852B2 (en) * 1994-11-17 2007-12-19 東レ株式会社 "Transdermal absorption preparation"
DE19526864A1 (en) * 1995-07-22 1997-01-23 Labtec Gmbh Hormone patches
DE19533089C1 (en) * 1995-09-07 1997-05-22 Hexal Ag Tacrine patch
DE19626621A1 (en) * 1996-07-02 1998-01-08 Hexal Ag Plaster for transdermal application of pergolide
DE19701949A1 (en) * 1997-01-13 1998-07-16 Jenapharm Gmbh Transdermal therapeutic system
PL335410A1 (en) * 1997-02-28 2000-04-25 Minnesota Mining & Mfg Medium for transcutaneous testosterone administration
FR2761889B1 (en) * 1997-04-11 1999-12-31 Oreal PHARMACEUTICAL, COSMETIC OR DERMO-PHARMACEUTICAL PATCH FOR THE DELIVERY OF SEVERAL ACTIVE COMPOUNDS OF DIFFERENT NATURE
US7011843B2 (en) 1997-10-01 2006-03-14 Lts Lohmann-Therapie Systeme Ag Method for protecting a human being against health impairment by ingestion of a transdermal therapeutic system
DE10019171A1 (en) * 2000-04-07 2001-10-18 Schering Ag Compositions for use as penetration enhancers in transdermal formulations for highly lipophilic active ingredients
DE10107663B4 (en) * 2001-02-19 2004-09-09 Lts Lohmann Therapie-Systeme Ag Testosterone-containing transdermal therapeutic system, process for its preparation and its use
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
MXPA05004278A (en) 2002-10-25 2005-10-05 Foamix Ltd Cosmetic and pharmaceutical foam.
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
AU2004266502B2 (en) * 2002-10-25 2010-09-23 Foamix Pharmaceuticals Ltd. Penetrating pharmaceutical foam
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
RU2491096C9 (en) 2007-09-13 2014-02-10 Басф Се Using hydrophobin polypeptides as penetration intensifier
WO2009069006A2 (en) 2007-11-30 2009-06-04 Foamix Ltd. Foam containing benzoyl peroxide
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
DE102008006791B4 (en) * 2008-01-30 2011-11-24 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system with urea component and method for its production
WO2010050889A1 (en) * 2008-10-31 2010-05-06 Moberg Derma Ab Topical composition comprising a combination of at least two penetration enhancing agents
US20120087872A1 (en) 2009-04-28 2012-04-12 Foamix Ltd. Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof
CA2769677A1 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
BR112012007473A2 (en) 2009-10-02 2019-05-07 Foamix Ltd tetracycline topical compositions and methods of use
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
US10398641B2 (en) 2016-09-08 2019-09-03 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417496A2 (en) * 1989-08-17 1991-03-20 Schering Corporation Transdermal nitroglycerin patch with penetration enhancers
WO1991005529A1 (en) * 1989-10-13 1991-05-02 Watson Laboratories, Inc. Drug delivery systems and matrix therefor
EP0430491A2 (en) * 1989-11-17 1991-06-05 Beta Pharmaceuticals Co. Transdermal delivery device for estradiol and process for manufacturing said device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5855411A (en) * 1981-09-28 1983-04-01 Nitto Electric Ind Co Ltd Base material composition and medicinal composition for external use
AU561608B1 (en) * 1985-11-04 1987-05-14 Paco Research Corp. Transdermal vasoactive delivery
EP0394429B1 (en) * 1988-10-27 1996-01-10 Schering Aktiengesellschaft Preparation for transdermal application containing gestodene
DE69010076T2 (en) * 1989-05-25 1994-12-08 Takeda Chemical Industries Ltd Transdermal therapeutic agent.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417496A2 (en) * 1989-08-17 1991-03-20 Schering Corporation Transdermal nitroglycerin patch with penetration enhancers
WO1991005529A1 (en) * 1989-10-13 1991-05-02 Watson Laboratories, Inc. Drug delivery systems and matrix therefor
EP0430491A2 (en) * 1989-11-17 1991-06-05 Beta Pharmaceuticals Co. Transdermal delivery device for estradiol and process for manufacturing said device

Also Published As

Publication number Publication date
JPH06509346A (en) 1994-10-20
PT100737A (en) 1993-10-29
AU2229892A (en) 1993-03-02
HU9400253D0 (en) 1994-05-30
FI940427A0 (en) 1994-01-28
ES2103952T3 (en) 1997-10-01
ATE151985T1 (en) 1997-05-15
HU217215B (en) 1999-12-28
GR3024097T3 (en) 1997-10-31
EP0596903A1 (en) 1994-05-18
WO1993002669A1 (en) 1993-02-18
NO940313L (en) 1994-01-28
NO940313D0 (en) 1994-01-28
DK0596903T3 (en) 1997-11-03
HUT66125A (en) 1994-09-28
FI940427A (en) 1994-01-28
CA2114537A1 (en) 1993-02-18
NO307736B1 (en) 2000-05-22
PT100737B (en) 1999-07-30
EP0596903B1 (en) 1997-04-23
DE59208408D1 (en) 1997-05-28
DE4210165A1 (en) 1993-02-04

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