AU6726698A - Use of interleukin-15 - Google Patents

Use of interleukin-15

Info

Publication number
AU6726698A
AU6726698A AU67266/98A AU6726698A AU6726698A AU 6726698 A AU6726698 A AU 6726698A AU 67266/98 A AU67266/98 A AU 67266/98A AU 6726698 A AU6726698 A AU 6726698A AU 6726698 A AU6726698 A AU 6726698A
Authority
AU
Australia
Prior art keywords
antibodies
alpha
inhibiting
compounds
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU67266/98A
Inventor
Hans Peter Raf Dooms
Walter Charles Fiers
Johan Adriaan Marc Grooten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vlaams Instituut voor Biotechnologie VIB
Original Assignee
Vlaams Instituut voor Biotechnologie VIB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8228040&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU6726698(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vlaams Instituut voor Biotechnologie VIB filed Critical Vlaams Instituut voor Biotechnologie VIB
Publication of AU6726698A publication Critical patent/AU6726698A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Abstract

The invention relates to the use of IL-15 inhibiting or eliminating compounds that interfere with the binding of IL-15 to its receptor for the manufacture of a pharmaceutical composition for suppression of formation of CD4<+> memory cells of the immune system. Such inhibiting or eliminating compounds are for example anti-IL-15 antibodies, anti-IL-15R alpha antibodies, fragments of these antibodies, e.g. the Fab or F(ab')2 fragment, soluble IL-15R alpha , fusion proteins consisting of soluble IL-15R alpha , and Fc fragment, compounds, e.g. peptides, binding and/or inhibiting functional IL-15 receptor, IL-15 antisense oligonucleotides.
AU67266/98A 1997-02-21 1998-02-23 Use of interleukin-15 Abandoned AU6726698A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97200515 1997-02-21
PCT/EP1998/001127 WO1998036768A1 (en) 1997-02-21 1998-02-23 Use of interleukin-15

Publications (1)

Publication Number Publication Date
AU6726698A true AU6726698A (en) 1998-09-09

Family

ID=8228040

Family Applications (1)

Application Number Title Priority Date Filing Date
AU67266/98A Abandoned AU6726698A (en) 1997-02-21 1998-02-23 Use of interleukin-15

Country Status (9)

Country Link
US (3) US6344192B1 (en)
EP (2) EP0971728B1 (en)
AT (2) ATE229342T1 (en)
AU (1) AU6726698A (en)
DE (2) DE69810091T2 (en)
DK (1) DK1273304T4 (en)
ES (1) ES2187946T3 (en)
WO (1) WO1998036768A1 (en)
ZA (1) ZA981478B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192935B1 (en) * 1993-03-08 2007-03-20 Amgen Inc. Polynucleotides encoding epithelium-derived T-cell factor and uses thereof
IL126919A0 (en) * 1998-11-05 1999-09-22 Univ Ben Gurion Antisense oligomer
US5985663A (en) * 1998-11-25 1999-11-16 Isis Pharmaceuticals Inc. Antisense inhibition of interleukin-15 expression
EP1927657A3 (en) * 2000-05-11 2008-10-22 Baylor Research Institute Compositions and methods for producing antigen-presenting cells
IL154925A0 (en) 2000-09-14 2003-10-31 Beth Israel Hospital Modulation of il-2 and il-15-mediated t cell responses
US7041302B2 (en) * 2001-01-09 2006-05-09 Biother Corporation Therapeutic modulation of the tumor inflammatory response
US7247304B2 (en) 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
US7329405B2 (en) 2001-08-23 2008-02-12 Genmab A/S Human antibodies specific for interleukin 15 (IL-15)
SI1425389T1 (en) 2001-08-23 2012-02-29 Genmab As Human antibodies specific for interleukin 15 (il-15)
CU23093A1 (en) * 2002-10-09 2005-10-19 Ct Ingenieria Genetica Biotech VACCINE COMPOSITION INCLUDING INTERLEUCINE-15 (IL-15)
DE602004022390D1 (en) 2003-03-26 2009-09-17 Apogenix Gmbh IMPROVED FC FUSION PROTEINS
CA2531773A1 (en) 2003-07-21 2005-02-17 Transgene S.A. Novel multifunctional cytokines
CU23472A1 (en) * 2004-09-17 2009-12-17 Ct Ingenieria Genetica Biotech ANTAGONIST PEPTIDE OF INTERLEUCINE-15
WO2007037780A2 (en) 2004-10-08 2007-04-05 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Adoptive immunotherapy with enhanced t lymphocyte survival
PT1899364T (en) 2005-05-17 2020-05-20 Univ Connecticut Compositions and methods for immunomodulation in an organism
EP1777294A1 (en) 2005-10-20 2007-04-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
US20070160578A1 (en) * 2005-12-14 2007-07-12 The Gov. Of The Usa As Represented By The Secretary Of The Dep. Of Health And Human Services Expansion of natural killer and CD8 T-cells with IL-15R/ligand activator complexes
CA2636111C (en) 2006-01-13 2018-04-03 The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells
US20080131415A1 (en) 2006-11-30 2008-06-05 Riddell Stanley R Adoptive transfer of cd8 + t cell clones derived from central memory cells
PT2160401E (en) 2007-05-11 2014-10-30 Altor Bioscience Corp Fusion molecules and il-15 variants
NZ703668A (en) 2007-06-27 2016-07-29 Us Sec Dep Of Health And Human Services Complexes of il-15 and il-15ralpha and uses thereof
EP3135294B1 (en) 2009-08-14 2020-06-03 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Use of il-15-il-15 receptor heterodimers to treat lymphopenia
AU2011305476B2 (en) 2010-09-21 2016-12-01 Altor Bioscience Corporation Multimeric IL-15 soluble fusion molecules and methods of making and using same
US11053299B2 (en) 2010-09-21 2021-07-06 Immunity Bio, Inc. Superkine
MX359513B (en) 2011-03-23 2018-10-01 Hutchinson Fred Cancer Res METHOD and COMPOSITIONS FOR CELLULAR IMMUNOTHERAPY.
CA2909576C (en) 2013-04-19 2023-07-18 Cytune Pharma Cytokine derived treatment with reduced vascular leak syndrome
EP3160498B1 (en) 2014-06-30 2021-10-06 Altor BioScience Corporation Il-15-based molecules and methods of use thereof
JP2019533449A (en) 2016-10-21 2019-11-21 アルター・バイオサイエンス・コーポレーション Molecules based on multimeric IL-15
WO2023086772A1 (en) 2021-11-12 2023-05-19 Xencor, Inc. Bispecific antibodies that bind to b7h3 and nkg2d

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747024A (en) * 1993-03-08 1998-05-05 Immunex Corporation Vaccine adjuvant comprising interleukin-15
US5574138A (en) * 1993-03-08 1996-11-12 Immunex Corporation Epithelium-derived T-cell factor
US5591630A (en) * 1994-05-06 1997-01-07 Immunex Corporation Monoclonal antibodies that bind interleukin-15 receptors
CA2205430C (en) * 1994-11-17 2001-09-04 University Of South Florida Method for making a medicament for treating secondary immunodeficiency
US5795966A (en) * 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
CA2231603C (en) * 1995-10-17 2009-04-21 Wayne State University Chicken interleukin-15 and uses thereof
US5870759A (en) * 1996-10-09 1999-02-09 Oracle Corporation System for synchronizing data between computers using a before-image of data
US6065018A (en) * 1998-03-04 2000-05-16 International Business Machines Corporation Synchronizing recovery log having time stamp to a remote site for disaster recovery of a primary database having related hierarchial and relational databases
US6356917B1 (en) * 1998-07-17 2002-03-12 Ncr Corporation Monitoring and raising alerts for database jobs
US6553392B1 (en) * 1999-02-04 2003-04-22 Hewlett-Packard Development Company, L.P. System and method for purging database update image files after completion of associated transactions
US6728879B1 (en) * 1999-06-02 2004-04-27 Microsoft Corporation Transactional log with multi-sector log block validation

Also Published As

Publication number Publication date
DE69830257T2 (en) 2006-02-02
DE69830257D1 (en) 2005-06-23
ZA981478B (en) 1998-08-24
EP0971728A1 (en) 2000-01-19
EP1273304A2 (en) 2003-01-08
ES2187946T3 (en) 2003-06-16
WO1998036768A1 (en) 1998-08-27
US6344192B1 (en) 2002-02-05
US20070134718A1 (en) 2007-06-14
ATE295736T1 (en) 2005-06-15
EP1273304B1 (en) 2005-05-18
DK1273304T3 (en) 2005-09-12
EP1273304B2 (en) 2009-07-15
DE69810091T2 (en) 2003-10-09
ATE229342T1 (en) 2002-12-15
US20020182178A1 (en) 2002-12-05
DE69830257T3 (en) 2009-10-15
EP0971728B1 (en) 2002-12-11
DE69810091D1 (en) 2003-01-23
DK1273304T4 (en) 2009-08-31
EP1273304A3 (en) 2003-04-23

Similar Documents

Publication Publication Date Title
AU6726698A (en) Use of interleukin-15
AU1332099A (en) Costimulating t-cell polypeptide, monoclonal antibodies, their preparation and use
BG102983A (en) Extramembrane protein 106 polypeptide of moraxella catarrhalis, its gene sequence and application
NZ503763A (en) Antigenic compositions and vaccines comprising a high molecular weight (HMW) protein of Clamydia for therapeutic and prophylactic use
EP1260521A3 (en) Immunoglobulin variants for specific Fc epsilon receptors
EP0724456A4 (en) Antibodies to cd40
EP0340793A3 (en) Endowing cells with antibody specificity
WO1995016038A3 (en) Humanized antibodies and uses thereof
IL195338A (en) Antibody comprising an fc variant comprising d or e amino acid substitution at position 239 and pharmaceutical composition and use thereof
IL109016A (en) Purified soluble vascular endothelial cell growth factor (vegf) inhibitor encoding purified dna, a process for its preparation and pharmaceutical compositions comprising it
NZ508381A (en) Antibodies, antagonists and agonists of the death domain containing receptor 5 (DR5)
MX9707021A (en) Il-17 receptor.
IL142905A0 (en) Functional antagonists of hedgehog activity
AU2441895A (en) Heterodimer polypeptide immunogen carrier composition and method
BR9916266A (en) Abrasive article bonded using a hybrid binder
NZ296265A (en) Receptors able to specifically bind to a bacillus thuringiensis (bt) toxin; recombinant expression systems including the receptors for host cells; use as pesticides and in chemotherapy
EP0770624A3 (en) Peptide capable of inducing immune response to human gastric cancer and agent containing it for preventing or treating human gastric cancer
AU4157501A (en) Her-2 binding antagonists
ATE314474T1 (en) CLONING OF THE GENE FOR THE T GONDII PROTEIN GP 28.5 PEPTIDE FRAGMENTS FROM THIS PROTEIN AND THEIR USES.
EP0992584A3 (en) Purified mammalian FLT3 ligands and agonists and antagonists thereof
WO1998039027A3 (en) Sialyl lewis antigens as targets for immunotherapy
AU641736B2 (en) Delivery of agents
AU6631796A (en) The h-y antigen
IL86710A0 (en) Polypeptide receptor for interleukin-2,antibodies against this polypeptide and pharmaceutical compositions containing the same
AU6760294A (en) Immunotherapeutic peptides derived from toxic shock syndrome toxin-1, antibodies thereto, their uses in pharmaceutical compositions and diagnosis