AU671881B2 - Novel Process for the Preparation of Lyophilised Peptides - Google Patents
Novel Process for the Preparation of Lyophilised Peptides Download PDFInfo
- Publication number
- AU671881B2 AU671881B2 AU55235/94A AU5523594A AU671881B2 AU 671881 B2 AU671881 B2 AU 671881B2 AU 55235/94 A AU55235/94 A AU 55235/94A AU 5523594 A AU5523594 A AU 5523594A AU 671881 B2 AU671881 B2 AU 671881B2
- Authority
- AU
- Australia
- Prior art keywords
- lyophilisate
- peptide
- ala
- phe
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired, expires
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Steroid Compounds (AREA)
- Manufacture Of Tobacco Products (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (7)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4305225A DE4305225A1 (en) | 1993-02-19 | 1993-02-19 | New manufacturing process for Cetrorelix lyophilisate |
DE4305225 | 1993-02-19 |
Publications (3)
Publication Number | Publication Date |
---|---|
AU5523594A AU5523594A (en) | 1994-08-25 |
AU671881B2 true AU671881B2 (en) | 1996-09-12 |
AU671881C AU671881C (en) | 2004-01-15 |
Family
ID=6480924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU55235/94A Expired AU671881C (en) | 1993-02-19 | 1994-02-17 | Novel Process for the Preparation of Lyophilised Peptides |
Country Status (29)
Country | Link |
---|---|
EP (2) | EP0611572B1 (en) |
JP (1) | JP4033919B2 (en) |
KR (2) | KR100355686B1 (en) |
CN (1) | CN1109557C (en) |
AT (1) | ATE193653T1 (en) |
AU (1) | AU671881C (en) |
BR (1) | BR9400617A (en) |
CA (1) | CA2115943C (en) |
CZ (2) | CZ284314B6 (en) |
DE (2) | DE4305225A1 (en) |
DK (1) | DK0611572T3 (en) |
ES (1) | ES2148247T3 (en) |
FI (1) | FI110059B (en) |
GR (1) | GR3034237T3 (en) |
HR (1) | HRP940117B1 (en) |
HU (1) | HU218281B (en) |
IL (1) | IL108704A (en) |
MX (1) | MX9401312A (en) |
NO (1) | NO316601B1 (en) |
NZ (2) | NZ250906A (en) |
PL (1) | PL177177B1 (en) |
PT (1) | PT611572E (en) |
RU (1) | RU2145234C1 (en) |
SG (1) | SG46632A1 (en) |
SI (1) | SI9400087B (en) |
SK (2) | SK283021B6 (en) |
TW (1) | TW387812B (en) |
UA (1) | UA43829C2 (en) |
ZA (1) | ZA941136B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7718599B2 (en) | 2000-05-18 | 2010-05-18 | Aeterna Zentaris Gmbh | Pharmaceutical administration form for peptides, process for its preparation, and use |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6828415B2 (en) * | 1993-02-19 | 2004-12-07 | Zentaris Gmbh | Oligopeptide lyophilisate, their preparation and use |
AR006598A1 (en) * | 1996-04-19 | 1999-09-08 | Merck Sharp & Dohme | "ANTI-FUNGOUS COMPOSITIONS, ITS USE IN THE MANUFACTURE OF MEDICINES AND A PROCEDURE FOR THE PREPARATION" |
DE19712718C2 (en) * | 1997-03-26 | 1999-09-23 | Asta Medica Ag | Immobilized and activity-stabilized complexes of LHRH antagonists and process for their preparation |
ES2207941T3 (en) * | 1998-04-23 | 2004-06-01 | Zentaris Gmbh | METHOD FOR THE TREATMENT OF FERTILITY DISORDERS. |
DE10040700A1 (en) * | 2000-08-17 | 2002-02-28 | Asta Medica Ag | Salts of biologically active peptides, their production and use |
US20030186892A1 (en) * | 2002-03-28 | 2003-10-02 | Rajneesh Taneja | Enhancement of endogenous gonadotropin production |
NZ538928A (en) | 2002-09-27 | 2006-10-27 | Zentaris Gmbh | Administration form for pharmaceutically active peptides with sustained release of active ingredient, and method for the production thereof |
EP1722819B1 (en) | 2004-03-12 | 2007-12-26 | Intercell AG | Method for solubilising peptide mixtures |
EP1674082A1 (en) | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Process for the manufacture of sterile suspensions or lyophilisates of low-soluble basic peptide complexes, pharmaceutical formulations comprising these complexes and their use as medicament |
CN101630607B (en) * | 2008-07-19 | 2012-04-25 | 浙江家泰电器制造有限公司 | Liquid heating ware overheating protection controller assembly |
CN101629758B (en) * | 2008-07-19 | 2012-09-26 | 浙江家泰电器制造有限公司 | Liquid heating ware overheating protection controller assembly |
RU2454221C2 (en) * | 2010-07-06 | 2012-06-27 | Общество с ограниченной ответственностью "Завод Медсинтез" | Method for preparing lyophilised antiviral agent |
JP2014502282A (en) | 2010-12-06 | 2014-01-30 | アストロン リサーチ リミテッド | Stable ready-to-use cetrorelix injection solution |
GB201022147D0 (en) * | 2010-12-31 | 2011-02-16 | Immune Targeting Systems Its Ltd | Formulation |
CN102423484B (en) * | 2011-11-23 | 2014-01-15 | 深圳翰宇药业股份有限公司 | Stable cetrorelix medicinal composition and preparation method thereof |
EP3015553A1 (en) | 2014-10-30 | 2016-05-04 | Biotecon Diagnostics GmbH | Stabilised reaction mixture |
RU2667128C2 (en) * | 2016-12-29 | 2018-09-14 | Герман Петрович Беккер | Composition for preparation of anti-tumor medication and method for preparation of anti-tumor medication based on it |
WO2020254952A1 (en) | 2019-06-17 | 2020-12-24 | Intas Pharmaceuticals Ltd. | A stable formulation of cetrorelix |
CN112717119B (en) * | 2021-01-27 | 2024-04-30 | 南京羚诺生物医药技术研究院有限公司 | Cetrorelix pharmaceutical composition and preparation method thereof |
US20240123021A1 (en) | 2021-06-25 | 2024-04-18 | Extrovis Ag | Pharmaceutical compositions |
CN114159544A (en) * | 2022-01-24 | 2022-03-11 | 福州华为医药技术开发有限公司 | Cetrorelix acetate for injection and preparation method thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3816386A (en) * | 1972-06-20 | 1974-06-11 | Abbott Lab | Purification process for gn-rh |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD141996A1 (en) * | 1979-02-21 | 1980-06-04 | Ingrid Wolf | METHOD FOR PRODUCING LYOPHILIZED LHRH PRAEPARATIONS |
CS230614B1 (en) * | 1982-08-06 | 1984-08-13 | Martin Cs Flegel | Analogues of realising factor for luteining and folliculstimulated hormon |
US4565804A (en) * | 1984-09-07 | 1986-01-21 | The Salk Institute For Biological Studies | GnRH Antagonists VI |
EP0268066A3 (en) * | 1986-10-17 | 1990-07-11 | Syntex (U.S.A.) Inc. | Fertility control and uterine therapy in dogs with luteinizing hormone releasing hormone antagonists |
DE3735614A1 (en) * | 1986-10-31 | 1988-07-28 | Asta Pharma Ag | Ifosfamide lyophilisate and process for its preparation |
US4801577A (en) * | 1987-02-05 | 1989-01-31 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
NZ226170A (en) * | 1987-09-18 | 1990-07-26 | Ethicon Inc | Stable freeze-dried pharmaceutical composition containing epidermal growth factor |
US5180711A (en) * | 1990-06-14 | 1993-01-19 | Applied Research Systems Ars Holding N.V. | Combined treatment with gnrh antagonist and gnrh to control gonadotropin levels in mammals |
CN1036343C (en) * | 1990-11-10 | 1997-11-05 | 天津市计划生育研究所 | Synthesis, products and its application for luleinizing hormone releasing hormone and antagonistic znalogue |
-
1993
- 1993-02-19 DE DE4305225A patent/DE4305225A1/en not_active Ceased
-
1994
- 1994-01-31 TW TW083100769A patent/TW387812B/en not_active IP Right Cessation
- 1994-02-04 SG SG1996006874A patent/SG46632A1/en unknown
- 1994-02-04 EP EP94101672A patent/EP0611572B1/en not_active Expired - Lifetime
- 1994-02-04 ES ES94101672T patent/ES2148247T3/en not_active Expired - Lifetime
- 1994-02-04 PT PT94101672T patent/PT611572E/en unknown
- 1994-02-04 DE DE59409389T patent/DE59409389D1/en not_active Expired - Lifetime
- 1994-02-04 DK DK94101672T patent/DK0611572T3/en active
- 1994-02-04 AT AT94101672T patent/ATE193653T1/en active
- 1994-02-04 EP EP99102340.9A patent/EP0947200B1/en not_active Expired - Lifetime
- 1994-02-14 CZ CZ94312A patent/CZ284314B6/en not_active IP Right Cessation
- 1994-02-14 CZ CZ98974A patent/CZ285768B6/en not_active IP Right Cessation
- 1994-02-17 AU AU55235/94A patent/AU671881C/en not_active Expired
- 1994-02-17 KR KR1019940002771A patent/KR100355686B1/en not_active IP Right Cessation
- 1994-02-17 PL PL94302266A patent/PL177177B1/en unknown
- 1994-02-17 JP JP02053294A patent/JP4033919B2/en not_active Expired - Lifetime
- 1994-02-17 NZ NZ250906A patent/NZ250906A/en not_active IP Right Cessation
- 1994-02-17 NZ NZ314707A patent/NZ314707A/en not_active IP Right Cessation
- 1994-02-18 SK SK195-94A patent/SK283021B6/en not_active IP Right Cessation
- 1994-02-18 FI FI940779A patent/FI110059B/en not_active IP Right Cessation
- 1994-02-18 HR HRP4305225.8 patent/HRP940117B1/en not_active IP Right Cessation
- 1994-02-18 NO NO940564A patent/NO316601B1/en not_active IP Right Cessation
- 1994-02-18 CA CA002115943A patent/CA2115943C/en not_active Expired - Lifetime
- 1994-02-18 ZA ZA941136A patent/ZA941136B/en unknown
- 1994-02-18 UA UA94005526A patent/UA43829C2/en unknown
- 1994-02-18 RU RU94005001A patent/RU2145234C1/en active
- 1994-02-18 SK SK810-2001A patent/SK283022B6/en not_active IP Right Cessation
- 1994-02-18 BR BR9400617A patent/BR9400617A/en not_active Application Discontinuation
- 1994-02-18 IL IL10870494A patent/IL108704A/en not_active IP Right Cessation
- 1994-02-18 SI SI9400087A patent/SI9400087B/en unknown
- 1994-02-18 HU HU9400481A patent/HU218281B/en unknown
- 1994-02-18 CN CN94101378A patent/CN1109557C/en not_active Expired - Lifetime
- 1994-02-21 MX MX9401312A patent/MX9401312A/en unknown
-
2000
- 2000-08-23 GR GR20000401924T patent/GR3034237T3/en unknown
-
2001
- 2001-02-27 KR KR1020010009932A patent/KR100372187B1/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3816386A (en) * | 1972-06-20 | 1974-06-11 | Abbott Lab | Purification process for gn-rh |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7718599B2 (en) | 2000-05-18 | 2010-05-18 | Aeterna Zentaris Gmbh | Pharmaceutical administration form for peptides, process for its preparation, and use |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
NBA | Allowances - extensions of time- section 223(1) |
Free format text: THE TIME IN WHICH TO FILE FURTHER INFORMATION UNDER REGULATION 6.11 HAS BEEN EXTENDED TO 20011023 |
|
PC | Assignment registered |
Owner name: ZENTARIS AKTIENGESELLSCHAFT Free format text: FORMER OWNER WAS: ASTA MEDICA AKTIENGESELLSCHAFT |
|
ON | Decision of a delegate or deputy of the commissioner of patents (result of patent office hearing) |
Free format text: REQUEST UNDER S. 70 FOR AN EXTENSION OF THE TERM OF THE PATENT, AND OBJECTIONS THERETO BY THE COMMISSIONER S DELEGATE Opponent name: THE COMMISSIONER S DELEGATE Effective date: 20021021 |
|
NDA | Extension of term for standard patent accepted (sect.70) |
Free format text: PRODUCT NAME: CETROTIDE CETRORELIX Extension date: 20160222 |
|
DA2 | Applications for amendment section 104 |
Free format text: THE NATURE OF THE PROPOSED AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20021121 |
|
DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS AS WAS NOTIFIED IN THE OFFICIAL JOURNAL DATED 20030605 |
|
NDB | Extension of term for standard patent granted (sect.76) |
Free format text: PRODUCT NAME: CETROTIDE CETRORELIX Extension date: 20160222 |
|
PC | Assignment registered |
Owner name: ZENTARIS GMBH Free format text: FORMER OWNER WAS: ZENTARIS AKTIENGESELLSCHAFT |