AU6587986A - 5-amino and 5-hydroxy-6,8-difluoroquinolones as antibacterial agents - Google Patents
5-amino and 5-hydroxy-6,8-difluoroquinolones as antibacterial agentsInfo
- Publication number
- AU6587986A AU6587986A AU65879/86A AU6587986A AU6587986A AU 6587986 A AU6587986 A AU 6587986A AU 65879/86 A AU65879/86 A AU 65879/86A AU 6587986 A AU6587986 A AU 6587986A AU 6587986 A AU6587986 A AU 6587986A
- Authority
- AU
- Australia
- Prior art keywords
- difluoroquinolones
- hydroxy
- amino
- antibacterial agents
- antibacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/808,122 US4668680A (en) | 1985-12-12 | 1985-12-12 | 5-amino-6,8-difluoroquinolones as antibacterial agents |
| US808122 | 1985-12-12 | ||
| US918568 | 1986-10-20 | ||
| US06/918,568 US4977154A (en) | 1985-12-12 | 1986-10-20 | 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6587986A true AU6587986A (en) | 1987-06-18 |
| AU591732B2 AU591732B2 (en) | 1989-12-14 |
Family
ID=27123084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU65879/86A Ceased AU591732B2 (en) | 1985-12-12 | 1986-12-02 | 5-amino and 5-hydroxy-6,8-difluoroquinolones as antibacterial agents |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4977154A (en) |
| EP (1) | EP0226961B1 (en) |
| KR (1) | KR900000555B1 (en) |
| CN (1) | CN1013114B (en) |
| AU (1) | AU591732B2 (en) |
| DE (1) | DE3679793D1 (en) |
| DK (1) | DK166493B1 (en) |
| ES (1) | ES2039198T3 (en) |
| FI (1) | FI865004A (en) |
| GR (1) | GR3002129T3 (en) |
| HU (1) | HU203231B (en) |
| IE (1) | IE59261B1 (en) |
| IL (1) | IL80933A (en) |
| NO (1) | NO865013L (en) |
| OA (1) | OA08561A (en) |
| PT (1) | PT83909B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU620401B2 (en) * | 1988-05-23 | 1992-02-20 | Shionogi & Co., Ltd. | Pyridonecarboxylic acids and antibacterial agents |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU594983B2 (en) * | 1985-10-29 | 1990-03-22 | Dainippon Pharmaceutical Co. Ltd. | Novel quinoline derivatives and processes for preparation thereof |
| EP0242789A3 (en) * | 1986-04-25 | 1990-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel quinoline derivates and processes for preparation thereof |
| DE3711193A1 (en) * | 1987-04-02 | 1988-10-13 | Bayer Ag | 5-SUBSTITUTED CHINOLON AND NAPHTHYRIDONE CARBONIC ACID DERIVATIVES |
| US4780468A (en) * | 1987-08-07 | 1988-10-25 | Warner-Lambert Company | 8-trifluoromethyl quinolones as antibacterial agents |
| US4933335A (en) * | 1987-08-07 | 1990-06-12 | Warner-Lambert Company | Quinolones as antibacterial agents |
| US4929613A (en) * | 1987-08-26 | 1990-05-29 | Warner-Lambert Company | Antibacterial agents |
| EP0339406A1 (en) * | 1988-04-19 | 1989-11-02 | Hokuriku Pharmaceutical Co.,Ltd | Quinoline-3-carboxylic acid derivatives, process for preparing the same, and composition exhibiting excellent antibacterial effect containing the same |
| AU618823B2 (en) * | 1988-07-20 | 1992-01-09 | Sankyo Company Limited | 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use |
| ES2147721T3 (en) | 1990-04-18 | 2000-10-01 | Procter & Gamble Pharma | QUINOLONYL ANTIMICROBIAL LACTAMS. |
| DE4019023A1 (en) * | 1990-06-14 | 1991-12-19 | Bayer Ag | METHOD FOR PRODUCING CHINOLINE CARBONIC ACIDS |
| CZ12097A3 (en) * | 1994-07-18 | 1997-09-17 | Ube Industries | Trifluoromethylquinolinecarboxylic acid derivatives and pharmaceutical composition containing thereof |
| US5866150A (en) * | 1996-03-20 | 1999-02-02 | Aquaculture Technology Incorporated | Antibacterially active extracts from the marine algae chaetoceros and methods of use |
| IN186245B (en) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
| CN1091103C (en) * | 1999-04-02 | 2002-09-18 | 中国科学院上海药物研究所 | Compounds of carbostyrils and their preparation and use |
| AU2001232238B2 (en) | 2000-02-09 | 2005-03-24 | Daiichi Pharmaceutical Co., Ltd. | Anti-acid-fast bacterial agents containing pyridonecarboxylic acids as the active ingredient |
| DE102004035203A1 (en) * | 2004-07-21 | 2006-02-16 | Bayer Healthcare Ag | Substituted quinolones |
| US8546423B2 (en) | 2005-05-18 | 2013-10-01 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| CN100415212C (en) * | 2006-07-21 | 2008-09-03 | 哈药集团制药总厂 | An oral preparation containing caderofloxacin lactate |
| WO2010042549A1 (en) | 2008-10-07 | 2010-04-15 | Mpex Pharmaceuticals, Inc. | Inhalation of levofloxacin for reducing lung inflammation |
| NZ592717A (en) | 2008-10-07 | 2013-03-28 | Mpex Pharmaceuticals Inc | Aerosol fluoroquinolone formulations for improved pharmacokinetics comprising levofloxacin or ofloxacin and a di- or trivalent cation |
| ES2739979T3 (en) | 2009-09-04 | 2020-02-05 | Horizon Orphan Llc | Use of levofloxacin spray for the treatment of cystic fibrosis |
| CN104557896A (en) * | 2013-10-18 | 2015-04-29 | 沈敬山 | Brexpiprezole, and preparation methods of key intermediate and salt thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2808070A1 (en) * | 1978-02-24 | 1979-08-30 | Bayer Ag | PROCESS FOR THE PRODUCTION OF 4-PYRIDONE-3-CARBONIC ACIDS AND / OR DERIVATIVES |
| DE3248506A1 (en) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7 (ALKYL-1-PIPERAZINYL) -3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS |
| DE3574380D1 (en) * | 1984-02-17 | 1989-12-28 | Daiichi Seiyaku Co | 1,8-naphthyridine derivatives |
| US4604401A (en) * | 1984-07-20 | 1986-08-05 | Warner-Lambert Company | Antibacterial agents III |
| JPS61205258A (en) * | 1985-03-08 | 1986-09-11 | Kyorin Pharmaceut Co Ltd | Quinolonecarboxylic acid derivative and production thereof |
| AU594983B2 (en) * | 1985-10-29 | 1990-03-22 | Dainippon Pharmaceutical Co. Ltd. | Novel quinoline derivatives and processes for preparation thereof |
-
1986
- 1986-10-20 US US06/918,568 patent/US4977154A/en not_active Expired - Fee Related
- 1986-11-25 IE IE310486A patent/IE59261B1/en not_active IP Right Cessation
- 1986-12-02 AU AU65879/86A patent/AU591732B2/en not_active Ceased
- 1986-12-08 FI FI865004A patent/FI865004A/en not_active Application Discontinuation
- 1986-12-09 DK DK590586A patent/DK166493B1/en not_active IP Right Cessation
- 1986-12-10 IL IL8680933A patent/IL80933A/en not_active IP Right Cessation
- 1986-12-10 KR KR1019860010553A patent/KR900000555B1/en not_active IP Right Cessation
- 1986-12-11 PT PT83909A patent/PT83909B/en not_active IP Right Cessation
- 1986-12-11 ES ES198686117250T patent/ES2039198T3/en not_active Expired - Lifetime
- 1986-12-11 HU HU865180A patent/HU203231B/en not_active IP Right Cessation
- 1986-12-11 OA OA59014A patent/OA08561A/en unknown
- 1986-12-11 EP EP86117250A patent/EP0226961B1/en not_active Expired - Lifetime
- 1986-12-11 DE DE8686117250T patent/DE3679793D1/en not_active Expired - Fee Related
- 1986-12-11 NO NO865013A patent/NO865013L/en unknown
- 1986-12-12 CN CN86108942A patent/CN1013114B/en not_active Expired
-
1991
- 1991-06-13 GR GR91400732T patent/GR3002129T3/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU620401B2 (en) * | 1988-05-23 | 1992-02-20 | Shionogi & Co., Ltd. | Pyridonecarboxylic acids and antibacterial agents |
Also Published As
| Publication number | Publication date |
|---|---|
| FI865004A0 (en) | 1986-12-08 |
| DK590586A (en) | 1987-06-13 |
| GR3002129T3 (en) | 1992-12-30 |
| DE3679793D1 (en) | 1991-07-18 |
| IL80933A0 (en) | 1987-03-31 |
| DK166493B1 (en) | 1993-06-01 |
| EP0226961A1 (en) | 1987-07-01 |
| PT83909B (en) | 1989-05-12 |
| IE59261B1 (en) | 1994-01-26 |
| CN86108942A (en) | 1987-11-04 |
| KR870006034A (en) | 1987-07-08 |
| PT83909A (en) | 1987-01-01 |
| HU203231B (en) | 1991-06-28 |
| OA08561A (en) | 1988-09-30 |
| NO865013D0 (en) | 1986-12-11 |
| HUT42470A (en) | 1987-07-28 |
| ES2039198T3 (en) | 1993-09-16 |
| US4977154A (en) | 1990-12-11 |
| CN1013114B (en) | 1991-07-10 |
| DK590586D0 (en) | 1986-12-09 |
| FI865004A (en) | 1987-06-13 |
| NO865013L (en) | 1987-06-15 |
| IL80933A (en) | 1991-06-10 |
| KR900000555B1 (en) | 1990-01-31 |
| AU591732B2 (en) | 1989-12-14 |
| IE863104L (en) | 1987-06-12 |
| EP0226961B1 (en) | 1991-06-12 |
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