AU653758B2 - Herbicidal substituted aryl-haloalkylpyrazoles - Google Patents

Herbicidal substituted aryl-haloalkylpyrazoles

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Publication number
AU653758B2
AU653758B2 AU89275/91A AU8927591A AU653758B2 AU 653758 B2 AU653758 B2 AU 653758B2 AU 89275/91 A AU89275/91 A AU 89275/91A AU 8927591 A AU8927591 A AU 8927591A AU 653758 B2 AU653758 B2 AU 653758B2
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Prior art keywords
chloro
methyl
trifluoromethyl
pyrazol
formula
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AU8927591A (en
Inventor
Gerard Anthony Dutra
Bruce Cameron Hamper
Deborah Aileen Mischke
Kurt Moedritzer
Michael David Rogers
Scott Stantford Woodard
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Monsanto Co
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Monsanto Co
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention herein relates to certain substituted-arylpyrazole compounds, herbicidal compositions containing same, herbicidal methods of use and processes for preparing said compounds.

Description

HERBICIDAL SUBSTITUTED ARYL-HALOALKYLPYRAZOLES
FIELD OF THE INVENTION
The field of the invention contemplated herein pertains to herbicidal compounds generically defined by the above title, to compositions containing same and processes for preparing said compounds.
BACKGROUND OF THE INVENTION
Various substituted 3-aryl- and 5-arylpyrazole type compounds are known in the literature. Such compounds have various utilities, e.g., as chemical intermediates, pharmaceuticals and herbicides.
Among the substituted 3-aryl-5-(halo)alkyl- pyrazoles and 5-aryl-3-(halo)alkylpyrazoles in the art are those having a variety of substituent radicals on the aryl and/or pyrazole moieties of the compound, e.g., alkyl, carboxyl, alkoxycarbonyl, formyl, phenyl and phenyl substituted with various groups such as alkyl, halo or nitro groups, etc. For example, compounds of this type are known wherein the aryl moiety is a
substituted or unsubstituted phenyl radical, in which the substituent radicals are alkyl, cycloalkyl, alkaryl, halogen, trifluoromethyl, etc., and the pyrazolyl radical is substituted in various positions on the nitrogen or carbon atoms with alkyl, halogen, alkoxy, hetero-cycles, S(O)nR members, wherein n is 0-2 and R may be a variety of radicals such as those substituted on the aryl or pyrazole moieties.
Compounds of the above type having utility as herbicides, typically require application rates as high as five or ten or more kilograms per hectare to achieve adequate weed control. Accordingly, it is an object of this invention to provide a novel class of arylpyrazole- type compounds having uniquely high phytotoxic unit activity against a spectrum of weeds, including narrowleaf and broadleaf weeds yet maintain a high degree of safety in a plurality of crops, especially small grains and/or row crops such as wheat, barley, corn, soybeans, peanuts, etc.
The 1-(halo)alkyl-3-(substituted)aryl-4-halo- 5-haloalkylpyrazoles and 1-(halo)alkyl-5-(substituted)- aryl-4-halo-3-haloalkylpyrazoles described herein are new.
SUMMARY OF THE INVENTION
This invention relates to herbicidally-active compounds, compositions containing these compounds, processes for making them and herbicidal methods of using the same.
The herbicidal compounds of this invention are characterized by the structure of Formula I
and agriculturally-acceptable salts and hydrates thereof wherein
R1 is independently C1 -8 alkyl; C3-8 cycloalkyl, cycloalkenyl, cycloalkylalkyl, or cycloalkenylalkyl; C2-8 alkenyl or alkynyl; benzyl; wherein the above members may be optionally substituted with halogen, amino, nitro, cyano, hydroxy, alkoxy, alkylthio, YR8, - R9, YR10, or NR11R12;
R2 is C1-5 haloalkyl;
R3 is halogen;
R4 is an R1 member, thioalkyl, alkoxyalkyl or polyalkoxyalkyl, carbamyl, halogen, amino, nitro, cyano, hydroxy, C1-10 heterocycle containing 1-4 O, S(O)m and/or NR18 hetero atoms, C6-12 aryl, aralkyl or alkaryl, YR13, R14, YR15 or NR16R17 group. Any two R4 groups may be combined through a saturated and/or unsaturated carbon, -(C=X)-, and/or hetero O, S(O)m and/or NR18 linkage to form a cyclic ring having up to 9 ring members which may be substituted with any of the R4 members;
X is O, S(O)m, NR19 or CR20R21;
Y is O, S(O)m or NR22;
R8-22 are hydrogen or one of the R4 members; m is 0-2 and
n is 1-5.
A preferred subgenus of the substituted- arylpyrazolyl compounds in this invention are those according to Formula II
and agriculturally-acceptable salts and hydrates thereof wherein
R1 is C1-5 alkyl, alkylthio, alkoxyalkyl,
C2-4 alkenyl, benzyl, which members may optionally be substituted with halogen, amino, nitro, cyano, hydroxy or - - YR8 groups;
R2, R3, X, Y and R8 are as defined for Formula
I;
R5 is halogen or hydrogen;
R6 and R7 are as defined for the R4 member of Formula I. Particularly preferred compounds of this invention are those according to Formula III
and agriculturally-acceptable salts and hydrates thereof wherein
R1 is C1-5 alkyl;
R2, R3 and R5 are as previously defined;
R6 is halogen, nitro, cyano, YR10;
R7 is hydrogen or an R4 member and
R6 and R7 are combined through a saturated and/or unsaturated carbon, -(C=X)-, and/or hetero O, S(O)m and/or NR18 linkage to form a cyclic ring having up to 9 ring members which may be substituted with any of the R4 members, provided that when said linkage contains -NR18-, said cyclic ring has at least six ring members and
X, Y, R18 and m are as previously defined.
Still more preferred are compounds according to Formula III and agriculturally-acceptable salts and hydrates thereof wherein
R1 is methyl;
R2 is CF3, CF2Cl or CF2H;
R3 is chloro or bromo;
R5 is fluoro; R6 is chloro ;
R7 is propargyloxy, allyloxy, polyalkoxy, OCH(R23)COR24 where R23 is hydrogen, methyl or ethyl and R24 is YR10 or NR11R12;
R6 and R7 are combined through an
-OCH2(C=O)N(R18)-linkage to give a fused six member ring and
Y, R10-R12 and R18 are as previously defined. Preferred species according to this invention include the following:
4-Chloro-3-(4-chloro-2-fluoro-5-propargyl- oxyphenyl)-1-methyl-5-(trifluoromethyl)- 1H-pyrazole,
2-(2-Chloro-5-(4-chloro-1-methyl-5-(tri- fluoromethyl)-1H-pyrazol-3-yl)-4- fluorophenoxy)propanoic acid, ethyl ester, (2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluoro- phenoxy)acetic acid, 1-methylethyl ester, 4-Chloro-3-(4-chloro-2-fluoro-5-(methoxy- methoxy)phenyl)-1-methyl-5- (trifluoromethyl)-1H-pyrazole,
4-Chloro-3-(4-chloro-2-fluoro-5-(methoxy- ethoxy)phenyl)-1-methyl-5-(trifluoro- methyl)-1H-pyrazole,
(2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluoro- phenoxy) acetic acid, 1,1-dimethylethyl ester,
(2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorophenoxy)- acetic acid,
2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 2-ethoxy-1-methyl-2-oxoethyl ester, 2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 2-methoxy-1-methyl-2-oxoethyl ester,
2-Chloro-5-(4-chloro-1-methyl-5-(trifluoro- methyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, ethyl ester,
2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 1-methylethyl ester and 6-(4-Chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-7-fluoro-4-(2-propynyl)-2H- 1,4-benzoxazin-3-(4H)-one.
While all of the above compounds have exhibited particularly efficacious use in a plurality of crops, tests to date indicate that those of most
preferred interest are the Compound Nos. 135, 137, 261, 282 and 446. These compounds collectively provide outstanding control of resistant broadleaf weeds such as pigweed, cocklebur, velvetleaf and hemp sesbania in various crops such as corn, soybean and nuts and in forestry against trees and vines. Other of the compounds of this invention exhibit excellent herbicidal effect against weeds in other crops such as wheat and barley.
Some of the compounds of the present invention may have more than one possible stereoisomer and these stereoisomers may differ in herbicidal efficacy. The structures illustrated are intended to include all possible stereoisomers.
The above compounds may be suitably applied in a variety of application modes, e.g., pre-emergent and/or postemergent, surface applied, pre-plant
incorporated, etc.
Another aspect of this invention relates to processes for preparing the compounds according to Formulae I-III and their precursors, intermediates and/or starting materials. These process aspects will be discussed in more detail below.
Other aspects of this invention relate to herbicidal compositions containing the compounds of Formulae I-III and to herbicidal methods of using those compositions to control undesirable weeds.
It is further within the purview of this invention that the substituted-arylpyrazole compounds of Formulae I-III be formulated in compositions containing other herbicidal compounds as co-herbicides, e.g., acetamides, esp., acetanilides, thiocarbamates, ureas, sulfonylureas, sulfonamides, imidazolinones, benzoic acid and its derivatives, diphenyl ethers, salts of glyphosate, etc.
other additaments may be included in such herbicidal formulations as desired and appropriate, e.g, antidotes (safeners) for the herbicide(s), plant disease control agents, such as fungicides, insecticides, nematicides and other pesticides.
As used herein, the terms "alkyl", "alkenyl", alkynyl" when used either alone or in compound form, e.g., haloalkyl, haloalkenyl, alkoxy, alkoxyalkyl, etc., are intended to embrace linear or branched-chain
members. Preferred alkyl members are the lower alkyls having from 1 to 4 carbon atoms and preferred alkenyl and alkynyl members are those having from 2 to 4 carbon atoms.
The term "haloalkyl" is intended to mean alkyl radicals substituted with one or more halogen (chloro, bromo, iodo or fluoro) atoms; preferred members of this class are those having from 1 to 4 carbon atoms, especially the halomethyl radicals, e.g., trifluoro- methyl. In polyhaloalkyl members, the halogens can all be the same or mixed halogens.
Representative, non-limiting alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl and cycloalkenylalkyl members include the following: Methyl, ethyl, the isomeric propyls, butyls, pentyls, hexyls, heptyls, octyls, nonyls, decyls, etc.; vinyl, allyl, crotyl, methallyl, the isomeric butenyls, pentenyls, hexenyls, heptenyls, octenyls; ethynyl, the isomeric propynyls, butynyls, pentynyls, hexynyls, etc.; the alkoxy, polyalkoxy, alkoxyalkyl and polyalkoxyalkyl analogs of the foregoing alkyl groups, e.g., methoxy, ethoxy, propoxys, butoxys, pentoxys and hexoxys and corresponding polyalkoxys and alkoxyalkyls, e.g., methoxymethoxy, methoxyethoxy, ethoxymethoxy, ethoxy- ethoxy, methoxymethyl, methoxyethyl, ethoxymethyl, ethoxyethyl, propoxymethyl, isopropoxymethyl, butoxy- methyl, isobutoxymethyl, tertbutoxymethyl, pentoxy- methyl, hexoxymethyl, etc., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, etc.; the isomeric cyclopentenes, cyclohexenes and cycloheptenes having mono- or di-unsaturation; representative aryl, aralkyl and alkaryl groups include phenyl, the isomeric tolyls and xylyls, benzyl, naphthyl, etc.
Representative mono-, di- and tri- haloalkyl members include: chloromethyl, chloroethyl, bromomethyl, bromoethyl, iodomethyl, iodoethyl, chloropropyl, bromopropyl, iodopropyl, 1,1,-dichloromethyl, 1,1-di- bromomethyl, 1,1-dichloropropyl, 1,2-dibromopropyl, 2,3- dibromopropyl, 1-chloro-2-bromoethyl, 2-chloro-3- bromopropyl, trifluoromethyl, trichloromethyl, etc.
Representative heterocyclic members include: alkylthiodiazolyl; piperidyl; piperidylalkyl; dioxo- lanylalkyl, thiazolyl; alkylthiazolyl; benzothiazolyl; halobenzothiazolyl; furyl; alkyl-substituted furyl;
furylalkyl; pyridyl; alkylpyridyl; alkyloxazolyl;
tetrahydrofurylalkyl; 3-cyanothienyl; thienylalkyl;
alkyl-substituted thienyl; 4,5-polyalkylene-thienyl; piperidinyl; alkylpiperidinyl; pyridyl; di- or tetra- hydropyridinyl; alkyltetrahydromorpholyl; alkylmor- pholyl; azabicyclononyl; diazabicycloalkanyl,
benzoalkylpyrrolidinyl; oxazolidinyl; perhydro- oxazolidinyl; alkyloxazolidyl; furyloxazolidinyl, thienyloxazolidinyl, pyridyloxazolidinyl, pyrimi- dinyloxazolidinyl, benzooxazolidinyl, C3-7 spiro- cycloalkyloxazolidinyl, alkylaminoalkenyl; alkyl- ideneimino; pyrrolidinyl; piperidonyl; perhydroazepinyl; perhydroazocinyl; pyrazolyl; dihydropyrazolyl; pipera- zinyl; perhydro-1,4-diazepinyl; quinolinyl, isoquino- linyl; di-, tetra- and perhydroquinolyl - or - iso- quinolyl; indolyl and di- and perhydroindolyl and said heterocyclic members substituted with radicals such as defined in Formulae I-III.
By " agriculturally-acceptable salts" of the compounds defined by the above formulae is meant a salt or salts which readily ionize in aqueous media to form a cation or anion of said compounds and the corresponding salt anion or cation, which salts have no deleterious effect on the herbicidal properties of a given herbicide and which permit formulation of various mixtures, e.g., herbicide-antidote compositions without undue problems of mixing, suspension, stability, applicator equipment use, packaging, etc.
By "herbicidally-effective" is meant the amount of herbicide required to effect a meaningful injury or destruction to a significant portion of affected undesirable plants or weeds. Although of no hard and fast rule, it is desirable from a commercial viewpoint that 80-85% or more of the weeds be destroyed, although commercially significant suppression of weed growth can occur at much lower levels, particularly with some very noxious, herbicide-resistant plants. DETAILED DESCRIPTION OF THE INVENTTON
The compounds according to this invention are suitably prepared by a variety of processes as will be described below.
In broad aspect, the preferred overall process for preparing the compounds of Formulae I-III is best viewed in the separate process steps required to get the necessary intermediates, immediate precursors and end products of the above formulae. The products of
"Process I" provide the intermediates necessary for
"Processes II-XVI". The products according to Formulae I-III are prepared by either a single process "II-XVI" or any combination of "Processes II-XVI". It is expressly understood that various modifications obvious to those skilled in the art are contemplated. Specific embodiments are described in Examples 1-42 below.
In the sequence of process steps described below, the various symbols defining radical substituents, e.g., R1-R24, X, Y, etc. have the same meanings as defined for the compounds of Formulae I-III, unless otherwise qualified or limited.
Process I
This process describes the preparation of important intermediate compounds of Formula B, or isomeric mixtures thereof, which are useful in the overall process scheme for producing compounds of
Formulae I-III.
The process for the preparation of a compound of Formula B suitably proceeds from compounds of Formula A. Compounds of Formula A are prepared by known means from substituted acetophenones, which also are known in the art; the structure shown for Formula A is meant to embody all possible tautomeric forms or mixtures
thereof. Compounds of Formula A can be prepared in any anhydrous solvent or mixture of solvents; the preferred solvents are ether, alcohols, dimethylsulfoxide, toluene, benzene, etc., by reacting a substituted acetophenone in the presence of an ester with a strong base such as an alkali alkoxide, alkali amide or alkali hydride with alkali alkoxides such as sodium methoxide being preferred. Reaction temperature is in the range of -100ºC to 200ºC, preferably -78ºC to 50ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. After completion of the reaction, the compound of Formula A is isolated by diluting the reaction mixture with water, which may be followed by acidification of the aqueous layer or, alternatively, by diluting the reaction mixture with aqueous acid. Subsequently, the product is isolated by a method such as crystallization or solvent extraction. If necessary, the product is purified by standard methods. The cyclization of this intermediate to give compounds of Formula B can be carried out in any
suitable solvent by treatment with hydrazine or
substituted hydrazines with alkylhydrazines being preferred. Reaction temperature is in the range of
-78º C to 200ºC, preferably 10ºC to 120ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. The product is isolated after completion of the reaction by filtration and/or concentration of the reaction mixture. If necessary, the product is purified by standard methods such as extraction, crystallization, column chromatography, etc.
In the case of the addition of hydrazine to compounds of Formula A, the resultant pyrazole of
Formula C may be treated with an alkylating agent to obtain compounds of Formula B. In this case, products of Formula B can be obtained by treatment of the above compound with an alkylating agent such as methyl iodide, benzyl bromide, allyl bromide, dimethylsulfate, etc.
The preferred solvents are toluene, dimethylsulfoxide, acetone, dimethylformamide, dioxane, etc. The reaction may be carried out with or without a base. In cases in which a base is employed, alkali metal carbonates or hydroxides such as sodium carbonate or sodium hydroxide may be used. Reaction temperature is in the range of -78ºC to 200ºC, preferably 10ºC to 120ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. The product is isolated after completion of the reaction by filtration and/or concentration of the reaction mixture. If necessary, the product is purified by standard methods such as extraction, crystallization, column chromatography, etc.
Compounds illustrated by Formula C can exist in two possible tautomeric forms, either a 5-aryl- pyrazole or a 3-arylpyrazole. The 5-arylpyrazole depicted in Formula C is meant to include both possible tautomeric forms. Table 1 shows typical examples of compounds of Formula C. In all tables herein, boiling points and melting points are measured in degrees Centigrade (ºC) and unless otherwise indicated refractive indices are at 25ºC.
* Compound No. 10 was prepared from Compound No. 9 by Process II. The 2-fluoro-4-chloro-5-methoxyacetophenone, used to prepare compound Nos. 3, 4 and 9 by the above process, was prepared from 2-chloro-4-fluoroanisole, which can be obtained from 2-chloro-4-fluorophenol by methods known in the art (C. A. Buehler and D. E.
Pearson, Survey of Organic Synthesis, pages 285-382, wiley-lnterscience, New York, 1970). Treatment of 2- chloro-4-fluoroanisole with titanium tetrachloride and dichloromethylmethylether at room temperature gives 2- fluoro-4-chloro-5-methoxybenzaldehyde. The 2-fluoro-4- chloro-5-methoxybenzaldehyde is converted to 2-fluoro- 4-chloro-5-methoxyacetophenone by treatment with methyl Grignard followed by oxidation using standard methods known in the art.
The above mentioned 2-fluoro-4-chloro-5- methoxyacetophenone and its analogous precursor, 2- fluoro-4-chloro-5-methoxybenzaldehyde and processes for preparing them are the discovery of other inventors (Bruce C. Hamper and Kindrick L. Leschinsky) employed by the assignee herein.
Tables 2 and 3 show typical examples of compounds prepared by Process I.
Process II
In this process description, one class of products according to Formula I wherein R3 is halogen is prepared by the halogenation of the corresponding compound of Formula B. In this process, R1 can be as previously defined and further include hydrogen.
Any inert solvent may be used in this reaction that does not markedly hinder the reaction from proceeding or the reaction may be carried out neat. Such solvents include, but are not limited to, organic acids, inorganic acids, hydrocarbons, halogenated hydrocarbons, aromatic hydrocarbons, ethers and sulfides, sulfoxides or sulf ones . Halogenating agents suitable for the above reaction include bromine, chlorine, N-bromosuccinimide, N-chlorosuccinimide, sulfuryl chloride, etc. With some halogenating agents it is preferable to use an organic peroxide or light as a catalyst. The amount of halo- genating agent can range from less than one molar equivalent to an excess. Reaction temperature is in the range of -100ºC to 200ºC, preferably 10ºC to 100ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. After completion of the reaction the product is isolated by diluting the reaction mixture with water and the product is isolated by a method such as crystallization or solvent
extraction. If necessary, the product is purified by standard methods. Process III
This section describes a process for the preparation of compounds according to Formula D (a
Formula I compound in which one of the R4 residues is a nitro group) starting with compounds according to
Formula I.
Nitrating agents such as concentrated nitric acid, fuming nitric acid, mixtures of nitric acid with concentrated sulfuric acid, alkyl nitrates and acetyl nitrate are suitable for this reaction. Solvents such as mineral acids, organic acids, organic solvents, such as acetic anhydride or methylene chloride, and water or mixtures of these solvents may be used. The nitrating agent may be used in equimolar amounts or in excess.
Reaction temperature is in the range of -100ºC to 200ºC, preferably -10ºC to 100ºC. The reaction period may be chosen from the range of a few minutes to several days depending on the amounts of reagents, reaction tempera- ture, etc. After completion of the reaction the product is isolated by diluting the reaction mixture with water and the product is isolated by methods such as crystallization or solvent extraction. If necessary, the product is purified by standard methods.
Process IV
In this process description, one class of products according to Formula F (one species of Formula II compounds) is prepared by displacement of the Z radical of the corresponding compound of Formula E, wherein Z is any suitable leaving group of the
previously defined R4 members.
Formation of products of Formula F can be carried out by treatment of compounds of Formula E with an alkoxide, thioalkoxide, amine, etc., or an alcohol, mercaptan, amine, etc., in the presence of a base in any suitable solvent or mixture of solvents. The preferred solvents are dimethylsulfoxide, acetone, dimethylformamide, dioxane, water, etc. or mixtures of solvents including two phase mixtures (such as water and methylene chloride or other organic solvent). The base may be an organic base (such as a trialkylamine or another organic amine) or an inorganic base (an alkali carbonate such as potassium carbonate or sodium carbonate or an alkali metal hydroxide such as sodium hydroxide). In the case of two immiscible liquid phases, it may be advantageous to add a phase transfer catalyst such as a benzyl- trialkylammonium halide or other ammonium salt.
Reaction temperature is in the range of -100ºC to 200ºC, preferably -10ºC to 100ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction
temperature, etc. The product is isolated after
completion of the reaction by filtration and/or
concentration of the reaction mixture. If necessary, the product is purified by standard methods such as extraction, crystallization, column chromatography, etc. Process V
In this process description, compounds of Formula I are prepared from compounds of Formula G
(Formula I compounds in which one of the R4 members is a nitro residue).
A. In the first step of this two step process, com- pounds according to Formula G are reduced to give a derivative according to Formula I wherein one of the R6 radicals is an amine group. Reducing agents suitable in an acidic medium include, but are not limited to, metals such as iron, zinc, or tin. The reaction solvent can include either organic or inorganic acids, such as acetic acid or hydrochloric acid, and may be used as concentrated acid solutions or dilute aqueous solutions. Reaction temperature is in the range of 0ºC to 200ºC, preferably 10ºC to 120ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction
temperature, etc.
After completion of the reaction the product is isolated by diluting the reaction mixture with water and the product is isolated by a method such as crystallization or solvent extraction. If necessary, the product is purified by standard methods.
Alternatively, compounds of Formula G may be reduced by catalytic hydrogenation. For catalytic hydrogenation, which may be carried out at atmospheric or elevated pressures, suitable catalysts include Raney nickel, palladium-carbon, palladium black, palladium on any suitable support, palladium oxide, platinum, platinum black, etc. Solvents include any inert solvent which does not markedly hinder the reaction including alcohols, ethers, etc. The product is isolated after completion of the reaction by filtration and concentration of the reaction mixture. If necessary, the product is purified by standard methods such as
extraction, crystallization, column chromatography, etc.
B. The amine radical of the product of step A can be converted to a variety of functional groups, e.g., a halogen (preferred), cyano, hydroxyl, etc. In the case of conversion of the amine radical to a halogen, a solution or slurry of the product of step A is treated with copper salts including cupric halides, cuprous halides, mixtures of cupric and cuprous halides or other copper salts and their mixtures and with an alkyl nitrite or organic nitrite such as t-butylnitrite. In this reaction any suitable solvent may be employed, although, anhydrous solvents such as anhydrous aceto- nitrile are preferred. Reaction temperature is in the range of 0ºC to 200ºC, preferably 10ºC to 100ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. The product is isolated after completion of the reaction by filtration and/or concentration of the reaction mixture. If necessary, the product is purified by standard methods such as extraction, crystallization, column
chromatography, etc.
Alternative process operations for converting the amine radical to various functional groups,
including those mentioned in the preceding paragraph include use of various conventional procedures, e.g., the Sandmeyer, Meerwein, etc., reactions which employ diazonium salts as intermediates.
Process VI
In this process description, compounds according to Formula I, wherein one of the R4 members is YH, are prepared from compounds according to Formula I wherein one of the R4 members is YR15 and R15 is not hydrogen. The reaction can be carried out as a solution or suspension in any suitable solvent or neat. A Lewis acid such as, but not limited to, BBr3, AlCl3, etc., or inorganic or organic acids such as concentrated or aqueous hydrochloric acid, sulfuric acid, hydrobromic acid, acetic acid, etc., can be employed. Alternatively, nucleophilic reagents for dealkylation may be employed including trimethylsilyl iodide, cyanide salts, mercaptide salts, alkali metal halides, etc. Reaction temperature is in the range of 0ºC to 200ºC, preferably 10ºC to 100ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. The product is isolated after completion of the reaction by filtration and/or concentration of the reaction mixture. If necessary, the product is purified by standard methods such as extraction, crystallization, column chromatography, etc.
Process VII
In this process description, compounds
according to Formula I (which includes Formulae II and III compounds), wherein one of the R4 members is YR15 and R15 is not hydrogen, are prepared from compounds
according to Formula I wherein one of the R4 members is YH or NR16R17.
In representative embodiments of this process, formation of products defined above can be carried out by treatment of the starting material with an alkylating agent such as an alkyl halide or alkyl sulfonate, e.g., methyl iodide, allyl bromide, propargyl bromide, methyl phenylsulfonate, etc., or an acylating agent. The reaction may be carried out in any suitable solvent or mixture of solvents, with or without a catalyst, in the presence or absence of a base. The preferred solvents are dimethylsulfoxide, acetone, dimethylformamide, dioxane, etc., or mixtures of solvents including two phase mixtures (such as water and methylene chloride or other organic solvent). In the case of two immiscible liquid phases, it may be advantageous to add a phase transfer catalyst such as a benzyltrialkylammonium halide or other ammonium salt. The base may be an organic base (such as a trialkylamine or another organic amine) or an inorganic base (an alkali carbonate or metal, such as potassium or sodium carbonate or sodium hydroxide). Reaction temperature is in the range of 0ºC to 200ºC, preferably 10ºC to 100ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. The product is isolated after completion of the reaction by filtration and/or concentration of the reaction mixture. If necessary, the product is purified by standard methods such as extraction,
crystallization, column chromatography, etc.
Process VIII
This process describes the preparation of compounds of Formula K (Formula II compounds wherein R7 is YCH2-p(R25)pCOYR27) from the corresponding compounds of Formula H. The radicals R25-27 are as previously defined for the said R4 members; the Y members are independently, as previously defined and p is an integer from 0 to 2.
A. In the first step of this two step
process , compounds of Formula H are converted to
compounds of Formula J by hydrolysis of the YR26 radical. The reaction can be carried out in any suitable solvent or mixture of solvents, with or without a catalyst, in the presence of a base or acid. The preferred solvents are water, alcohols, dioxane, dimethylsulfoxide, acetic acid, acetone, dimethylformamide, etc. In the case of base hydrolysis, inorganic bases such as alkali hydroxides are preferred. For acid hydrolysis, inorganic acids such as concentrated hydrochloric acid or sulfuric acid, organic acids or mixtures of such acids may be employed. Reaction temperature is in the range of about 0ºC to 200ºC, preferably 10ºC to 100ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. After completion of the reaction the product is isolated by diluting the reaction mixture with water and/or treating the solution with acid (in the case of base hydrolysis) and the product is isolated by a method such as crystallization or solvent extraction. If necessary, the product is purified by standard methods.
B. The last step of this process is meant to include the transformation of compounds of Formula J to compounds of Formula K by any of the variety of standard techniques for the preparation of derivatives of carboxylic acids. This process step is an esterification or an amide-forming reaction. The esterification can be carried out by using an excess of the alcohol corresponding to the objective ester in the presence of a mineral acid (e.g., sulfuric acid). The amide derivatives can be prepared by treating compounds of Formula J with the desired amine either neat or in a suitable solvent. The esterification or amide-forming reactions can also be carried out in the presence of an inert solvent and a dehydrating agent.
Alternatively, the product of step A can be converted to an acid halide or anhydride and treated with an alcohol or amine. Preparation of the acid halide is carried out in the presence of a halogenating agent such as, but not limited to, thionyl chloride, phosphorus pentachloride, oxalyl chloride, etc., with or without an inert solvent. Any inert solvent which does not interfere with the reaction may be employed. A catalytic amount of an amine base such as triethylamine, pyridine or dimethylformamide or the like may be added for the purpose of promoting this reaction. The reaction temperature is in the range of -20ºC to the boiling point of the solvent used. The reaction period ranges from several minutes to 48 hours depending upon the amounts of reactants used and the reaction temperature. After completion of the reaction, the excess
halogenating reagent and solvent (s) are removed from the reaction product by evaporation or distillation. The resultant acid halide may be subjected to an amine or alcohol directly or purified by the usual means.
The acid halide is treated with an alcohol or amine to give a compound of Formula K. The reaction can be carried out in the absence of a solvent, in the presence of an inert solvent or with a mixture of solvents including two phase mixtures (such as water and methylene chloride or other organic solvent). A base such as triethylamine, pyridine, alkali metal hydroxide and/or a catalytic amount of a phase transfer catalyst such as a benzyltrialkylammonium halide or other
ammonium salt may be added for the purpose of promoting this reaction. The reaction temperature is in the range of -20º C to the boiling point of the solvent used. The reaction period ranges from several minutes to 48 hours depending upon the amounts of reactants used and the reaction temperature. The product is isolated after completion of the reaction by filtration and/or
concentration of the reaction mixture. If necessary, the product is purified by standard methods such as extraction, crystallization, column chromatography, etc.
Compounds required as starting materials for Processes IX through XI are obtained by the above
Processes II-VIII.
Process IX
In this process description, compounds
according to Formula N are prepared from compounds according to Formula L (Formula II compounds wherein R6 is YCH2-q(R28)qCOOR29, R7 is a nitro radical, Y is as previously defined, q is an integer from 0 to 2 and radicals R28-30 are as previously defined for the said R4 members), as described below. A. In the first step of this two step
process, compounds according to Formula L are converted to compounds of Formula M by reduction of the nitro radical to an amine radical and subsequent cyclization. By choice of the reaction conditions, one can obtain either the uncyclized amine (Formula L compounds wherein the nitro radical is substituted by an amine radical) or the cyclized product. Typically, reaction conditions are chosen such that the cyclized product is obtained directly. Alternatively, the uncyclized amine can be isolated by standard methods and cyclized to give compounds of Formula M in a separate step using standard conditions. Reducing agents suitable in an acidic medium include, but are not limited to, metals such as iron, zinc or tin. The reaction solvent can include either organic or inorganic acids, such as acetic acid or hydrochloric acid, and may be used as concentrated acid solutions or dilute aqueous solutions. Reaction temperature is in the range of 0ºC to 200ºC, preferably 10ºC to 120ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc.
After completion of the reaction the product is separated by diluting the reaction mixture with water and isolated by a method such as crystallization or solvent extraction. If necessary, the product is purified by standard methods.
Alternatively, compounds of Formula L may be reduced by catalytic hydrogenation. For catalytic hydrogenation, which may be carried out at normal or elevated pressures, suitable catalysts include Raney nickel, palladium-carbon, palladium black, palladium on any suitable support, palladium oxide, platinum, platinum black, etc. Solvents include any inert solvent which does not markedly hinder the reaction including alcohols, ethers, etc. By choice of the reaction
conditions, one can obtain either the uncyclized amine (Formula L compounds wherein the nitro radical is substituted by an amine radical) or the cyclized
product. Typically, reaction conditions are chosen such that the cyclized product is obtained directly. Alternatively, the uncyclized amine can be isolated by standard methods and cyclized to give compounds of
Formula M in a separate step using standard conditions. The product is isolated after completion of the reaction by filtration and concentration of the reaction mixture. If necessary, the product is purified by standard methods such as extraction, crystallization, column chromatography, etc.
B. In this step the product of step A is converted to compounds of Formula N. Formation of products defined above can be carried out by treatment of compounds of Formula M with an alkylating agent such as an alkyl halide or alkyl sulfonate, e.g., methyl iodide, allyl bromide, propargyl bromide, methyl phenylsulfonate, etc., or an acylating agent. The reaction may be carried out in any suitable solvent or mixture of solvents, with or without a catalyst, in the presence or absence of a base. The preferred solvents are dimethylsulfoxide, acetone, dimethylformamide, dioxane, etc., or mixtures of solvents including two phase mixtures (such as water and methylene chloride or other organic solvent). In the case of two immiscible liquid phases, it may be advantageous to add a phase transfer catalyst such as a benzyltrialkylammonium halide or other ammonium salt. The base may be an organic base (such as a trialkylamine or another organic amine) or an inorganic base such as potassium or sodium carbonate or hydroxide. Reaction temperature is in the range of 0ºC to 200ºC, preferably 10ºC to 120ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. The product is isolated after completion of the reaction by filtration and/or concentration of the reaction mixture. If necessary, the product is purified by standard methods such ras extraction, crystallization, column chromatography, etc.
Process X
In this process description, compounds according to Formula Q wherein R33 is not hydrogen are prepared from compounds according to Formula O (Formula II compounds wherein R6 is a nitro radical, R7 is
YCH2-r(R31)rCOOR32, Y is as previously defined, r is an integer from 0 to 2 and radicals R31-33 are as previously defined for the said R4 members.
A. In the first step of this two step process, compounds according to Formula O are converted to compounds of Formula P by reduction of the nitro radical to an amine radical and subsequent cyclization. By choice of the reaction conditions, one can obtain either the uncyclized amine (Formula O compounds wherein the nitro radical is substituted by an amine radical) or the cyclized product. Typically, reaction conditions are chosen such that the cyclized product is obtained directly. Alternatively, the uncyclized amine can be isolated by standard methods and cyclized to give compounds of Formula P in a separate step using standard conditions. Reducing agents suitable in an acidic medium include, but are not limited to, metals such as iron, zinc or tin. The reaction solvent can include either organic or inorganic acids, such as acetic acid or hydrochloric acid, and may be used as concentrated acid solutions or dilute aqueous solutions. Reaction temperature is in the range of 0ºC to 200ºC, preferably 10ºC to 120ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. After completion of the reaction the product is separated by diluting the reaction mixture with water and isolated by a method such as crystallization or solvent extraction. If necessary, the product is purified by standard methods.
Alternatively, compounds of Formula O may be reduced by catalytic hydrogenation. For catalytic hydrogenation, which may be carried out at normal or elevated pressures, suitable catalysts include Raney nickel, palladium-carbon, palladium black, palladium on any suitable support, palladium oxide, platinum,
platinum black, etc. Solvents include any inert solvent which does not markedly hinder the reaction including alcohols, ethers, etc. By choice of the reaction conditions, one can obtain either the uncyclized amine (Formula 0 compounds wherein the nitro radical is substituted by an amine radical) or the cyclized product. Typically, reaction conditions are chosen such that the cyclized product is obtained directly. Alternatively, the uncyclized amine can be isolated by standard methods and cyclized to give compounds of Formula P in a separate step using standard conditions. The product is isolated after completion of the reaction by filtration and concentration of the reaction mixture. If necessary, the product is purified by standard methods such as extraction, crystallization, column chromatography, etc.
B. In this step the product of step A is converted to compounds of Formula Q wherein R33 is not hydrogen. Formation of products defined above can be carried out by treatment of compounds of Formula P with an alkylating agent such as an alkyl halide or alkyl sulfonate, e.g., methyl iodide, allyl bromide, propargyl bromide, methyl phenylsulfonate, etc., or an acylating agent. The reaction may be carried out in any suitable solvent or mixture of solvents, with or without a catalyst, in the presence or absence of a base. The preferred solvents are dimethylsulfoxide, acetone, dimethylformamide, dioxane, etc. The base may be an organic base (such as a trialkylamine or another organic amine) or an inorganic base such as potassium or sodium carbonate or hydroxide. Reaction temperature is in the range of 0ºC to 200ºC, preferably 10ºC to 120ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. The product is isolated after completion of the reaction by filtration and/or concentration of the reaction mixture. If necessary, the product is purified by standard methods such as extraction, crystallization, column
chromatography, etc.
Process XI
This section describes a process for the preparation of compounds according to Formula S from compounds of Formula R (Formula II compounds wherein R6 is an amino radical, R7 is YC(R34)sCCR35, Y is as
previously defined, s is an integer from 0 to 2 and the radicals R34-36 are any of the previously defined R4 members).
The process for the preparation of compounds of Formula S suitably proceeds from compounds of Formula R. In this reaction any suitable solvent may be
employed, although anhydrous solvents such as anhydrous acetonitrile are preferred. A solution or slurry of a compound of Formula R is treated with copper salts including cupric halides, cuprous halides, mixtures of cupric and cuprous halides or ether copper salts and their mixtures and with an alkyl nitrite or organic nitrite such as t-butylnitrite. Reaction temperature is in the range of 0ºC to 200ºC, preferably 10ºC to 100ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. The product is isolated after completion of the reaction by filtration and/or concentration of the reaction mixture. If necessary, the product is purified by standard methods such as extraction, crystallization, column
chromatography, etc.
Process XII
This process describes the preparation of compounds of Formulae U, V, W, X, Y or Z (Formula II compounds in which the R7 substituent is alkyl,
substituted alkyl, haloalkyl, carboxaldehyde, carboxylic acid or a carboxylic acid derivative such as the
previously defined CXYR8 or CXR9) from compounds of Formula T. The radicals R37 and R38 are as previously defined for the R4 members and X1 and X2 are halogens. Process schematics are shown below.
In the first step of this process, compounds of Formula T are converted to either compounds of
Formula U or W or a mixture of these products. Any inert solvent may be used in this reaction that does not markedly hinder the reaction from proceeding. Such solvents include, but are not limited to, organic acids, inorganic acids, hydrocarbons, halogenated hydrocarbons, aromatic hydrocarbons, ethers, sulfoxides or sulfones. Halogenating agents suitable for the above reaction include bromine, chlorine, N-bromosuccinimide, N- chlorosuccinimide, sulfuryl chloride, etc. With some halogenating agents it is preferable to use an organic peroxide or light as a catalyst. The amount of halogenating agent can range from less than one molar amount to an excess. Reaction temperature is in the range of -78ºC to 200ºC, preferably 10ºC to 120ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. After completion of the reaction the product or products are isolated by
diluting the reaction mixture with water and the
product(s) are isolated by a method such as crystallization or solvent extraction. If necessary, the product(s) are purified by standard methods.
Compounds of Formula U can be converted to compounds of Formula V by displacement of the halogen radical X1 by a suitable nucleophile. Formation of products of Formula V can be carried out by treatment of compounds of Formula U with an alkoxide, thioalkoxide, cyanide, amine, alkyl or aryl anion, etc., or an
alcohol, mercaptan, amine, etc., in the presence of a base in any suitable solvent or mixture of solvents. The preferred solvents are dimethyl-sulfoxide, acetone, dimethylformamide, dioxane, water, etc., or mixture of solvents including two-phase mixtures (such as water and methylene chloride or other organic solvent). The base may be an organic base (such as a trialkylamine or another organic amine) or an inorganic base (an alkali carbonate such as potassium carbonate or sodium
carbonate or an alkali metal hydroxide such as sodium hydroxide). In the case of two immiscible liquid phases, it may be advantageous to add a phase transfer caralyst such as a benzyltrialkylammonium halide or other ammonium salt. Reaction temperature is in the range of -78ºC to 200ºC, preferably 10ºC to 120ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. The product is isolated after completion of the reaction by filtration and/or concen-tration of the reaction mixture. If necessary, the product is purified by standard methods such as extraction, crystallization, column
chromatography, etc.
Formation of products of Formula X can be carried out by acid hydrolysis of compounds of Formula W. To effect acid hydrolysis, compounds of Formula W are subjected to an excess of a mineral acid such as hydrochloric acid or sulfuric acid, with excess of sulfuric acid being preferred. Reaction temperature is in the range of 0ºC to the boiling point of the inert solvent, preferably 10ºC to 100ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. After completion of the reaction the product or products are separated by diluting the reaction mixture with water and are isolated by a method such as crystallization or solvent extraction. If necessary, the product (s) are purified by standard methods.
Compounds of Formula Y are obtained by
oxidation of Formula X compounds. Any suitable inert solvent may be employed in this reaction including hydrocarbons, aromatic hydrocarbons, pyridine and its derivatives, water, etc. Oxidizing agents employed include, but are not limited to, potassium permanganate or potassium dichromate. Reaction temperature is in the range of- 50ºC to the boiling point of the inert
solvent, preferably 10ºC to 100ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. After completion of the reaction the product or products are separated by diluting the reaction mixture with water and isolated by a method such as crystallization or solvent extraction. If necessary, the product (s) are purified by standard methods.
The last step of this process is meant to include the transformation of compounds of Formula Y to compounds of Formula Z by any of the variety of standard techniques for preparation of derivatives of carboxylic acids . This process step is an esterif ication or an amide-forming reaction. This may be accomplished directly from compound of Formula Y or via an alkali metal salt of compound of Formula Y. The esterification can be carried out by using an excess of the alcohol corresponding to the objective ester in the presence of a mineral acid (e.g., sulfuric acid). The amide
derivatives can be prepared by treating compound of Formula Y with the desired amine either neat or in a suitable solvent. The esterification or amide-forming reactions can also be carried out in the presence of an inert solvent and a dehydrating agent.
Alternatively, compounds of Formula Y can be converted to an acid halide or anhydride and treated with an alcohol or amine. Preparation of the acid halide is carried out in the presence of a halogenating agent such as, but not limited to, thionyl chloride, phosphorus pentachloride, oxalyl chloride, etc., with or without an inert solvent. Any inert solvent which does not interfere with the reaction may be employed. A catalytic amount of an amine base such as triethylamine, pyridine or dimethylformamide or the like may be added for the purpose of promoting this reaction. The
reaction temperature is in the range of -20ºC to the boiling point of the solvent used. The reaction period ranges from several minutes to 48 hours depending upon the amounts of reactants used and the reaction temperature. After completion of the reaction, the excess halogenating reagent and solvent (s) are removed from the reaction product by evaporation or distillation. The acid halide is treated with an alcohol or amine to give a compound of Formula Z. The reaction can be carried out in the absence of a solvent, in the presence of an inert solvent or with a mixture of solvents including two phase mixtures (such as water and methylene chloride or other organic solvent). A base such as triethylamine, pyridine, alkali metal and/or a catalytic amount of a phase transfer catalyst such as a benzyltrialkyl- ammonium halide or other ammonium salt may be added for the purpose of promoting this reaction. The reaction temperature is in the range of -20ºC to the boiling point of the solvent used. The reaction period ranges from several minutes to 48 hours depending upon the amounts of reactants used and the reaction temperature. The product is isolated after completion of the reaction by filtration and/or concdentration of the reaction mixture. If necessary, the product is purified by standard methods such as extraction, crystallization, column chromatography, etc.
Process XIII
This section describes a process for the preparation of compounds according to Formula I in which one of the R4 residues is a thiol group (Formula AA) starting with compounds according to Formula I.
In this process, the desired compounds are obtained by preparation of a halosulfonyl intermediate followed by reduction to give compounds of Formula AA. Any solvent may be employed that does not hinder the progress of the reaction such as halogenated hydrocarbons, ethers, alkylnitriles, mineral acids, etc. An excess of chlorosulfonic acid is preferred as both the reagent and solvent for the formation of chlorosulfonyl intermediates. The reaction temperature is in the range of 25ºC to the boiling point of the solvent employed. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. After completion of the reaction the product or products are isolated by diluting the reaction mixture with water and the pro- duetts) are isolated by a method such as crystallization or solvent extraction. If necessary, the product(s) are purified by standard methods.
Reduction of the halosulfonyl intermediate can be carried out in organic or inorganic acids, such as acetic acid or hydrochloric acid, or mixtures of these acids in inert solvents. Reducing agents suitable in an acidic medium include, but are not limited to, metals such as iron, zinc or tin. Reaction temperature is in the range of 0ºC to 150ºC, preferably 10ºC to 120ºC. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc.
After completion of the reaction the product is isolated by diluting the reaction mixture with water and the product is isolated by a method such as crystal lization or solvent extraction. If necessary, the product is purified by standard methods.
Process XIV
This section describes a process for the preparation of compounds according to Formula I in which one of the R4 residues is a cyclic (thio)ketal or (thio)- acetal radical (Formula CC) starting with compounds according to Formula BB.
R39 is hydrogen or a previously-defined R4 member; A and B are independently 0 or S and n is an integer from 0 to 2. In this process, the desired compounds of Formula CC are prepared from compounds of Formula BB by conversion of the carbonyl group to a cyclic (thio)acetal or
(thio)ketal group. The aldehyde or ketone group of a compound of Formula BB is treated with a diol, dithiol or hydroxythiol. Any solvent may be employed that does not hinder the progress of the reaction such as
halogenated hydrocarbons, aromatic hydrocarbons, ethers, alkyl-nitriles, mineral acids, etc. Alternatively, the reaction may be carried out in the absence of a solvent. Typically, the reaction is carried out in the presence of an acid such as mineral acids, organic acids, etc. The reaction temperature is in the range of 25ºC to the boiling point of the solvent employed. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. After completion of the reaction the product or products are isolated by concentration of the reaction mixture and purified by a method such as crystallization or solvent extraction. If necessary, the product (s) are further purified by standard methods.
Process XV
This section describes a process for the preparation of compounds according to Formula DD
starting with compounds according to Formula BB.
R39-R41 are hydrogen or previously-defined R4 members.
Compounds of Formula DD are prepared by conversion of the ketone or aldehyde group of compounds of Formula BB to an alkene group. This transformation can be carried out by treatment of a compound of Formula BB with a Wittig type reagent such as an alkylidenephosphorane, ylides derived from phosphonium salts or phosphonate esters, alkylidenesulfuranes, etc. Suitable solvents include, but are not limited to, aromatic hydrocarbons, alcohols, alkanes, ethers, halogenated hydrocarbons, etc. The reaction temperature is in the range of -50ºC to the boiling point of the solvent employed. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction temperature, etc. After completion of the reaction the product or products are isolated by concentration of the reaction mixture and the product(s) are purified by a method such as crystallization or solvent extraction. If necessary, the product (s) are further purified by standard methods.
Process XVI
This section describes a process for the preparation of compounds according to Formula EE starting with compounds according to Formula BB.
R39 and R42 are as previously defined for the R4 members. In this process step, compounds of Formula EE which have an oxime substituent as one of the phenyl radicals are prepared from compounds of Formula BB. The ketone or aldehyde substituent of a compound of Formula BB can be converted to an oxime by either of two methods. The starting aldehyde or ketone of Formula BB can be treated with an O-substituted oxime to afford an oxime of
Formula EE. This compound may be further derivatized by standard methods known by those skilled in the art.
Examples of this approach include, but are not limited to, treatment of the aldehyde or ketone with
(aminooxy)acetic acid or other 2-(aminooxy)carboxylic acids and conversion of the resultant carboxylic acid to any of a number of carboxylic acid derivatives such as amides, esters, thioesters, etc. Alternatively, the oxime can be prepared by treatment of compounds of
Formula BB with hydroxylamine or hydroxylamine salts. The resultant oxime can be alkylated to afford
derivatives by treatment with an alkylating agent such as alkyl halides, alkyl sulfonates, etc. Suitable solvents for the above reactions include, but are not limited to, aromatic hydrocarbons, alkanes, ethers, alcohols, halogenated hydrocarbons, etc. The reaction temperature is in the range of -50ºC to the boiling point of the solvent employed. The reaction may be carried out with or without a base. In cases in which a base is employed, sodium acetate, alkali metal carbonates such as sodium carbonate or alkali metal
hydroxides such as sodium hydroxide may be used. The reaction period may be chosen from the range of a few minutes to several weeks depending on the amounts of reagents, reaction tempera-ture, etc. After completion of the reaction the product or products are isolated by concentration of the reaction mixture and the product (s) are purified by a method such as crystallization or solvent extraction. If necessary, the product (s) are further purified by standard methods. The following Examples 1-42 describe specific working embodiments for the preparation of representative compounds according to this invention.
Examples 1 through 4 describe specific working embodiments of Process I.
Example 1
This example describes the preparation of 3- (2,5-difluorophenyl)-1-methyl-5-(trifluoromethyl)-1H- pyrazole (Compound No. 40) and of 5-(2,5-difluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole
(Compound No. 20).
A. 28.5g of 2,5-difluoroacetophenone and 26g of ethyl trifluoroacetate were stirred in 400ml of anhydrous ether and cooled in an ice bath. 42ml of 25 wt % sodium methoxide in methanol was then added over 5 minutes. After stirring 1 hour at room temperature, the reaction mixture was extracted with water, the water acidified and extracted with methylene chloride to give 42g of 1-(2,5-difluorophenyl)-3-(trifluoromethyl)- propane-1,3-dione.
B. 34.5g of 1-(2,5-difluorophenyl)-3-
(trifluoromethyl)-propane-1,3-dione was dissolved in 250ml of acetic acid and 9.5 mL of methylhydrazine slowly added. The mixture was heated at 100ºC for 5 minutes then cooled and diluted with ether. The ether solution was washed with water and potassium carbonate solution, then dried with magnesium sulfate, filtered and concentrated. The residue was chromatographed to give 9.5 g of 3-(2,5-difluorophenyl)-1-methyl-5- (trifluoro-methyl)-1H-pyrazole.
Anal. Calc. for C11H7N2F5: C,50.39%; H,2.69%; N,10.68%.
Found: C,50.48%; H,2.72%; N, 10.64%. and 21.11g of 5-(2,5-difluorophenyl)-1-methyl-3-(tri- fluoromethyl)-1H-pyrazole (mp 38-39ºC).
Anal. Calc. for C11H7N2F5: C,50.39%; H,2.69%; N,10.68%.
Found: C,50.63%; H,2.65%; N, 10.40%.
Example 2
This example describes the preparation of 5-(2,4-difluorophenyl)-3-(trifluoromethyl)-1H-pyrazole (Compound No. 6).
A. To a solution of 40.0g (0.256 moles)
2',4'-difluoroacetophenone (commercially available) in 400mL diethyl ether at 0ºC was added 40mL (0.405 moles) ethyl trifluoroacetate. At 5ºC, 80mL of a 25% wt.
sodium methoxide in methanol (0.37 moles) were added over 15 minutes. The reaction mixture was stirred overnight at 25ºC. The mixture was poured over 300 mL ice water and 21.3mL (0.37 moles) acetic acid were added. The organic layer was washed two times with water, dried over anhydrous MgSO4, and concentrated in vacuo to give 62.85g (97%) 4-(2,4-difluorophenyl)-1,1,1- trifluoro-4-hydroxy-3-buten-2-one as a yellow oil; 1HNMR (CDCl3) ppm: 6.61 (s,1H), 6.87 (m,1H), 6.97 (m,1H), 7.97 (m,1H).
Anal. Calc. for C10H5F5O2; C,47.64; H,2.00.
Found: C, 47.70; H,1.96.
B. At 24ºC, 15.0g (0.06 mole) of the product of step A was dissolved in 50mL glacial acetic acid and treated with 2 mL (0.064 mole) anhydrous hydrazine, added over a period of 5 minutes. The reaction was heated to 95ºC for 30 minutes. The reaction was cooled and poured into 300mL ice water. The slurry was
filtered and the cake washed with water and air dried to give 13.86g (94%) of 5-(2,4-difluorophenyl)-3-(tri- fluoromethyl)-1H-pyrazole as a white solid, mp 157- 158ºC.
Anal. Calc. for C10H5F5N2: C,48.40; H,2.03; N, 11.29.
Found: C,48.38 ; H, 2 . 03 ; N , 11. 32 .
Example 3
This example describes the preparation of 3- (2,4-difluorophenyl)-1-methyl-5-(trifluoromethyl)-1H- pyrazole (Compound No. 42) and of 5-(2,4-difluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole
(Compound No. 21).
A slurry of 13.6g (0.055 mole) of the product of step B, 7.7g (0.056 mole) K2CO3, and 3.7mL (0.06 mole) methyl iodide in 150mL acetone was stirred overnight at 25ºC. The solution was diluted with 300mL cold water and extracted three times with ethyl acetate. The ethyl acetate extracts were washed with brine, dried over anhydrous MgSO4, and concentrated in vacuo . The residue was purified chromatographically using 5% ethyl acetate in hexane as the eluent to give 8.3g (58%) of 3-(2,4- difluorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole as a white solid, mp 51ºC.
Anal. Calc. for C11H7F5N2: C,50.39; H,2.69; N, 10.68.
Found: C,50.36; H,2.70; N,10.70.
The chromatography described in the above preparation gave a second fraction which was collected, concentrated and the residue crystallized to give 4.0g (28% yield) 5- (2,4-difluorophenyl)-1-methyl-3-(trifluoromethyl)-1H- pyrazole as a white solid, mp 37-38ºC.
Anal. Calc. for C11H7F5N2: C,50.39; H,2.69; N,10.68.
Found: C,50.40; H,2.67; N, 10.67.
Example 4
This example describes the preparation of 3-
(2,5-difluorophenyl)-1-methyl-5-(trifluoromethyl)-1H- pyrazole (Compound No. 40). A solution of 8.5g (34 mmole) of dry 5-(2,5- difluorophenyl)-1H-3-(trifluoromethyl)-1H-pyrazole in 100mL of anhydrous toluene was heated to reflux in an apparatus equipped with a Dean-Stark trap and treated with 3.25mL of dimethylsulfate. The mixture was
refluxed for 5 hours, allowed to cool and washed with 10% w/v aqueous NaOH. The organic phase was dried with MgSO4 and concentrated to afford 7.74g (86.2%) of a clear, almost colorless oil nD 1.4925 (25ºC).
Anal. Calc. for C11H7N2F5: C,50.39%; H,2.69%; N,10.68%.
Found: C,50.48%; H,2.72%; N, 10.64%.
Examples 5 through 7 describe specific working embodiments of Process II.
Example 5
This example describes the preparation of 4- chloro-5-(2,5-difluorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole (Compound No. 361).
At 25ºC, 5.24g (0.02 mole) 3-(2,5-difluoro- phenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole was dissolved in 40mL glacial acetic acid and 2.1g (0.03 mole) chlorine gas was bubbled in over a period of 1 hour. The reaction mixture was allowed to stir for 2 hours. The reaction solution was poured into 200mL ice water and extracted with ethyl acetate. The organic layer was washed with water, a saturated NaHCO3 solution, brine and dried over anhydrous MgSO4, and stripped in vacuo . The residue was purified chromatographically using 3% ethyl acetate in hexane as the eluent to give 5.87g (99%) of 4-chloro-5-(2,5-difluorophenyl)-1-methyl- 5-(trifluoro-methyl)-1H-pyrazole as a light yellow oil n25 1.4977.
Anal. Calc. for C11H6Cl1F5N2: C44.54; H,2.04; N,9.44;
Cl, 11.95.
Found: C,44.53; H,2.00; N,9.44;
Cl, 11.94. Examole 6
This example describes the preparation of 4- chloro-3-(2,5-difluoro-4-nitrophenyl)-1-methyl-5-(tri- fluoromethyl)-1H-pyrazole (Compound No. 389).
To 5.00g of 3-(2,5-difluoro-4-nitrophenyl)-1- methyl-5-(trifluoromethyl)-1H-pyrazole dissolved in 50ml of acetic acid was added 15ml of sulfuryl chloride. The mixture was mildly refluxed with 2ml portions of sulfuryl chloride added every 15 minutes. After 6 hours, the mixture was cooled, then diluted with water and extracted with ether. The ether was washed 3 times with water, dried with anhydrous magnesium sulfate, filtered and concentrated. The residue was chromatographed to give a quantitative yield of 4-chloro-3-(2,5-difluoro- 4-nitrophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole.
Anal. Calc. for C11H5N3O2Cl1F5: C,38.67%; H,1.48%;
N,12.30%.
Found: C, 38.73%; H,1.48%;
N,12.34%.
Example 7
This example describes the preparation of 4- chloro-3-(4-chloro-2-fluoro-5-methoxyphenyl)-1-(1- methylethyl)-5-(trifluoromethyl)-1H-pyrazole (Compound No. 489).
To a solution of 1.6g of 3-(4-chloro-2-fluoro- 5-methoxyphenyl)-1-(1-methylethyl)-5-(trifluoromethyl)- 1H-pyrazole in 20mL of dimethylformamide was added 2.0g of N-chlorosuccinimide. The solution was heated to 80ºC for 2 hours, allowed to cool and poured into ice water. The aqueous mixture was extracted three times with methylene chloride, the combined organic extracts washed with water, dried with MgSO4 and concentrated to give a crude oil . The oil was purif ied by chromatography and distilled bulb-to-bulb to afford 1.54g of 4-chloro-3- (4-chloro-2-fluoro-5-methoxyphenyl)-1-(1-methylethyl)- 5-(trifluoromethyl)-1H-pyrazole as a yellow oil, nD 1.5192 (24ºC). Anal. Calc. for C14H12N2O1F4Cl1: C,45.31%; H,3.26%;
N,7.55%.
Found: C,45.19%; H,3.27%;
N,7.49%.
Examples 8 through 10 describe specific working embodiments of Process III.
Example 8
This example describes the preparation of 3-
(2,5-difluoro-4-nitrophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole (Compound No. 388).
To an ice cooled solution of 50ml of fuming nitric acid (90%) was added slowly 8.29g of 3-(2,5-di- fluorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole. After addition, the mixture was allowed to warm to room temperature and then gently heated to 52ºC. Heated for 2.5 hours, then cooled and poured onto ice. The
resulting mixture was extracted with ether and the ether then washed twice with water, dried with anhydrous magnesium sulfate, filtered and the solvent removed by concentration in vacuo. The residue was purified utilizing a combination of chromatography and crystallization to give 5.62g of 3-(2,5-difluoro-4-nitro- phenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole, mp 80-81ºC.
Anal. Calc. for C11H6N3O2F5: C,43.01%; H,1.97%;
N,13.68%.
Found: C,42.99%; H,1.97%;
N, 13.68%.
Example 9
This example describes the preparation of 4- bromo-3-(2,5-difluoro-4-nitrophenyl)-1-methyl-5-(tri- fluoromethyl)-1H-pyrazole (Compound No. 396).
At 15ºC, 9.5g (0.03 mole) 4-bromo-3-(2,5- difluorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole was slowly added to 100mL of fuming nitric acid. The reaction warmed to 28ºC over a period of 20 minutes. The reaction mixture was stirred at 30ºC for 4 hours. The mixture was poured into 500mL of ice. After stirring for 1 hour, the slurry was extracted 3 times with methylene chloride. The methylene chloride extracts were washed with water, dried over anhydrous MgSO4, and concentrated in vacuo . The residue was purified chroma-tographically using 10% ethyl acetate in hexane as the eluent to give 5.84g (55%) of 4-bromo-3- (2,5-difluoro-4-nitrophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole as a white solid, mp 45.5ºC.
Anal. Calc. for C11H5Br1F5N3O2: C,34.22; H,1.31;
N, 10.88.
Found: C, 34.25; H,1.38;
N, 10.76.
Example 10
This example describes the preparation of 4- chloro-3-(2,5-difluoro-4-nitrophenyl)-1-methyl-5-(tri- fluoromethyl)-1H-pyrazole (Compound No. 389).
A solution of 5.9g of 4-chloro-5-(2,5-di- fluorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole in 6mL of concentrated H2SO4 was cooled to 15ºC and treated dropwise with a solution of 1.8g of 70% HNO3 in 2mL of concentrated H2SO4. The reaction mixture was allowed to stir at 30ºC for 5 hours and subsequently treated with an additional 1.8g of 70% HNO3. After stirring overnight at room temperature, the mixture was poured into 250mL of ice water and extracted with methylene chloride. The methylene chloride extract was washed three times with saturated aqueous NaHCO3, twice with water, dried with MgSO4 and concentrated in vacuo . The resultant material was chromatographed through silica using 10% ethyl acetate in hexane as the eluant to afford 3.93g (58%) of 4-chloro-3-(2,5-difluoro-4- nitrophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole. Anal. Calc. for C11H5N3O2Cl1F5: C,38.67%, H,1.48%;
N, 12.30%.
Found: C,38.73%; H,1.48%;
N,12.34.
Examples 11 through 15 describe specific working embodiments of Process IV.
Example 11
This example describes the preparation of 4- chloro-3-(2-fluoro-5-methoxy-4-nitrophenyl)-1-methyl-5- (trifluoromethyl)-1-pyrazole (Compound No. 390).
5.04g of 4-chloro-3-(2,5-difluoro-4-nitro- phenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole was dissolved in anhydrous ether and the solution cooled with an ice bath, then 3.7ml of a 25 wt. % sodium methoxide in methanol was added. After addition, the ice bath was removed and the mixture stirred for 30 minutes at room temperature. The solution was then extracted 4 times with water, dried with anhydrous magnesium sulfate, filtered and concentrated. The residue was chromatographed to give 4.63g of 4-chloro- 3-(2-fluoro-5-methoxy-4-nitrophenyl)-1-methyl-5-(tri- fluoromethyl)-1H-pyrazole, mp 115-116ºC.
Anal. Calc. for C12H8N3O3Cl1F4: C,40.75%; H,2.28%;
N,11.88%.
Found: C,40.84%; H,2.24%;
N, 11.83%.
Example 12
This example describes the preparation of 4- chloro-3-(2-fluoro-4-methoxy-5-nitrophenyl)-1-methyl-5- (trifluoromethyl)-1H-pyrazole (Compound No. 387).
At 35'C, 13.7g (0.04 mole) 4-chloro-3-(2,4- difluoro-5-nitrophenyl)-1-methyl-5-(trifluoromethyl)- 1H-pyrazole, 5.5g (0.04 mole) K2CO3, and 100mL methanol were stirred for 1 hour. The reaction was cooled, diluted with 100mL cold water, and extracted four times with ethyl acetate. The ethyl acetate extracts were washed with brine, dried over anhydrous MgSO4, and stripped in vacuo . The residue was purified chromatographically using 25% ethyl acetate in hexane as the eluent to give 13.0g (90%) of 4-chloro-3-(2-fluoro-4- methoxy-5-nitrophenyl)-1-methyl-5-(trifluoromethyl)-1H- pyrazole as a white solid, mp 116ºC.
Anal. Calc. for C12H8Cl1F4N3O3: C,40.75; H,2.28;
N, 11.88.
Found: C, 40.74; H,2.34;
N,11.90.
Example 13
This example describes the preparation of (5- (4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3- yl)-4-fluoro-2-nitrophenyl)thio-acetic acid, ethyl ester (Compound No. 393).
At 25ºC, 1.5g (4.5 mmole) 4-chloro-3-(2,5- difluoro-4-nitrophenyl)-1-methyl-5-(trifluoromethyl)- 1H-pyrazole, 0.69g (5.0 mmole) K2CO3, 0.55mL (5.0 mmole) ethyl mercaptoacetate, and 0.05g (0.5 mmole) CuF2 were slurried in 15mL 1-methy1-2-pyrrolidinone. The reaction mixture was stirred 28ºC for 24 hours. The mixture was cooled, diluted with 100mL cold water, and extracted four times with ethyl acetate. The ethyl acetate extracts were washed with brine, dried over anhydrous MgSO4, and stripped in vacuo . The residue was purified chromato-graphically using 10% diethyl ether and 15% methylene chloride in hexane as the eluent to give 0.86g (43%) of (5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-4-fluoro-2-nitrophenyl) thio-acetic acid, ethyl ester as a yellow solid, mp 79ºC.
Anal. Calc. for C15H12Cl1F4N3O4S1: C,40.78; H,2.74;
N,9.51; S,7.26.
Found: C,40.89; H,2.69;
N,9.61; S,7.31. Example 14
This example describes the preparation of 5- (4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3- yl)-4-fluoro-N-methyl-2-nitro-N-propylbenzeneamine
(Compound No. 402).
At 25ºC, 6.83g (0.02 mole) 4-chloro-3-(2,5- difluoro-4-nitrophenyl)-1-methyl-5-(trifluoromethyl)- 1H-pyrazole, 4.1g (0.03 mole) K2CO3, 3.1mL (0.03 mole) N- methyl-N-propylamine and a catalytic amount of CuF2 were slurried in 50mL 1-methyl-2-pyrrolidinone. The reaction mixture was stirred at 35ºC for 2 hours. The mixture was cooled , diluted with 100mL cold water , and extracted four times with ethyl acetate. The ethyl acetate extracts were washed with brine, dried over anhydrous MgSO4, and stripped in vacuo . The residue was purified chromatographically using 15% ethyl acetate in hexane as the eluent to give 6.8g (86%) of 5-(4-chloro-1-methyl- 5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluoro-N-methyl- 2-nitro-N-propylbenzeneamine as an orange oil, 1.5534. Anal. Calc. for C15H15Cl1F4N4O2: C45.64; H,3.83;
N,14.19.
Found: C,45.52; H,3.87;
N,14.32. Example 15
This example describes the preparation of (4- (4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3- yl)-5-fluoro-2-nitrophenoxy)acetic acid, butyl ester (Compound No. 498).
A solution of 3.4g (0.01 mole) 4-chloro-3-
(2,4-difluoro-5-nitrophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole and 1.4mL (0.011 mole) butyl
glycolate in 25mL anhydrous THF was chilled to 0ºC.
Maintaining the temperature below 5ºC, 0.33g (0.011 mole) NaH was added in portions. Once the addition was completed, the reaction mixture was allowed to warm to 25ºC. After 3 hours the mixture was carefully quenched with water and extracted with ethyl acetate. The ethyl acetate extracts were washed with brine, dried over anhydrous MgSO4, and concentrated in vacuo . The residue was purified chromatographically with 20% ethyl
acetate/hexanes to yield 3.25g (72%) (4-(4-chloro-1- methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-fluoro-2- nitrophenoxy) acetic acid, butyl ester as a light yellow solid; mp 65ºC.
Anal. Calc. for C17H16Cl1F4N3O5: C,45.00; H,3.55;
N,9.26.
Found: C,44.97; H,3.56;
N,9.29.
Examples 16 through 19 describe specific working embodiments of Process V.
Example 16
This example describes the preparation of 4- chloro-3-(4-chloro-2-fluoro-5-methoxyphenyl)-1-methyl- 5-(trifluoromethyl)-1H-pyrazole (Compound No. 312).
A. To a solution of 4.05g of 4-chloro-3-(2- fluoro-5-methoxy-4-nitrophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole in 50ml of acetic acid was added 1.39g (0.0249mol) of iron powder. The reaction mixture was heated near reflux for 2 hours, treated with 1.39g of iron powder, and heated at near reflux for another hour. After cooling, concentrating and chromatography, 3.54g of 4-chloro-3-(4-amino-2-fluoro-5-methoxyphenyl)- 1-methyl-5- (trif luoromethyl) -1H-pyrazole was isolated.
B. 3.064g of 4-chloro-3-(4-amino-2-fluoro-5- methoxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole was dissolved in 50ml of anhydrous acetonitrile and
1.90g of anhydrous cupric chloride added. 1.93ml of t- butyl nitrite (tech., 90%) dissolved in 10ml of
anhydrous acetonitrile was then added dropwise over 10 minutes, stirred an additional 20 minutes and then concentrated. The residue was taken up in ethyl acetate, extracted 3 times with 10% aqueous HCl, dried with anhydrous magnesium sulfate, filtered, concenrrated and chromatographed to give 2.10g of 4-chloro-3-(4- chloro-2-fluoro-5-methoxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole, mp. 70-71ºC.
Anal. Calc. for C12H8N2O1Cl1F4: C,42.01%; H,2.35%;
N,8.16%.
Found: C,42.15%; H,2.34%;
N,8.18%.
Example 17
This example describes the preparation of 2- chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-4-fluoro-N-methyl-N-propylbenzenamine (Compound No. 166).
A. A solution of 5.2g (0.013 mole) 5-(4- chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4- fluoro-N-methyl-2-nitro-N-propylbenzenamine in 100mL acetic acid was heated to 80ºC under a nitrogen
atmosphere. The heat and nitrogen were removed and 2.2g (0.039) mole iron powder was added in 3 portions over 5 min. The solution was stirred at 80ºC for an additional 30 min. The solution was cooled and filtered through Celite®. The filtrate was diluted with 100mL water and extracted three times with ethyl acetate. The ethyl acetate extracts were washed with a saturated NaHCO3 solution, dried over anhydrous MgSO4, and concentrated in vacuo . The residue was purified chromatographically using 30% ethyl acetate in hexane as the eluent to give 3.85g (80%) of 5-(4-chloro-1-methyl-5-(trifluoromethyl)- 1H-pyrazol-3-yl)-4-fluoro-N-methyl-N-propyl-1,2- benzenediamine as a light yellow oil, 1.5352.
Anal. Calc. for C15H17Cl1F4N4: C,49.39; H,4.70;
N,15.36.
Found: C,49.40; H,4.64;
N,15.16.
B. All equipment was flame dried under nitrogen. A solution of 3.35g (9.2 mmole) of the product of step A in 60mL acetonitrile at 25ºC was treated with 0.9g (9.2 mmole) CuCl and 1.8g (13.3 mmole) CuCl2. A solution of 2.2mL (18.4 mmole) 90% t-butyl nitrite was added over 5 minutes. After 2 hours at 28ºC the reaction mixture was stripped in vacuo . The
reaction residue was taken up in ethyl acetate and washed three times with a 10% HCl solution, two times with brine and dried over anhydrous MgSO4, and concentrated in vacuo . The residue was purified chromatographically using 20% ethyl acetate in hexane as the eluent to give 2.45g (70%) of 2-chloro-5-(4-chloro-1- methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluoro-N- methyl-N-propylbenzenamine as a clear colorless oil, 1.5030. Anal. Calc. for C15H15Cl2F4N3: C,46.89; H,3.94;
N,10.94.
Found: C, 46.84; H,3.83;
N, 10.93.
Example 18
This example describes the preparation of 4- bromo-3-(4-chloro-2-fluoro-5-methoxyphenyl)-1-methyl-5- (trifluoromethyl)-1H-pyrazole (Compound No. 313).
A. A solution of 3.16g (7.9 mmole) 4-bromo-3- (2-fluoro-5-methoxy-4-nitrophenyl)-1-methyl-5-(tri- fluoromethyl)-1H-pyrazole in 59mL acetic acid was heated to 80ºC under a nitrogen atmosphere. The heat and nitrogen were removed and 1.76g (31.6 mmole) iron powder was added in 3 portions over 5 min. The solution was stirred at 80ºC for an additional 30 min. The solution was cooled and filtered through Celite®. The filtrate was diluted with 100mL water and extracted three times with diethyl ether. The ether extracts were washed with brine, dried over anhydrous MgSO4, and concentrated in vacuo . The residue was purified chromatographically using 40% ethyl acetate in hexane as the eluent to give 2.4g (83%) of 4-(4-bromo-1-methyl-5-(trifluoromethyl)- 1H-pyrazol-3-yl)-5-fluoro-2-methoxy-benzeneamine as a white solid, mp 85-86ºC. Anal . Calc . for C12H10Br1F4N3O1 : C, 39 . 15 ; H, 2 . 74 ;
N, 11.41.
Found: C,39.13; H,2.74;
N,11.40.
B. All equipment was flame dried under nitrogen. A solution of 6.6g (0.0179 mole) of the product of step A in 100mL acetonitrile was cooled to 5ºC. 1.8g (0.018 mole) CuCl and 3.7g (0.027 mole) CuCl2 were added at 5ºC. A solution of 4.8mL (0.036 mole) 90% t-butyl nitrite in 15mL acetonitrile was added over 15 minutes. The reaction mixture was stirred at 5ºC for 15 minutes and then allowed to warm to 28ºC. After 2 hours at 28ºC the reaction mixture was stripped in vacuo. The reaction residue was taken up in diethyl ether and washed three times with a 10% HCl solution, two times with brine and dried over anhydrous MgSO4, and concentrated in vacuo . The residue was purified chromatographically using 20% ethyl acetate in hexane as the eluent to give 6.3g (91%) of 4-bromo-3-(4-chloro-2- fluoro-5-methoxyphenyl)-1-methyl-5-(trifluoromethyl)- 1H-pyrazole as a white solid, mp 85-86ºC.
Anal. Calc. for C12H8Br1Cl1F4N2O1: C,37.19; H,2.08;
N,7.23.
Found: C, 37.23; H,2.08;
N,7.24.
Example 19
This example describes the preparation of 4- chloro-3-(5-chloro-2,4-difluorophenyl)-1-methyl-5- (trifluoromethyl)-1H-pyrazole (Compound No. 354).
A. A solution of 3.4g (0.01 mole) 4-chloro-3- (2,4-difluoro-5-nitrophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole in 50mL acetic acid was heated to 80ºC under a nitrogen atmosphere. The heat and nitrogen were removed and 1.7g (0.03 mole) iron powder was added in 3 portions over 5 min. The solution was stirred at 80ºC for an additional 30 min. The solution was cooled and filtered through Celite®. The filtrate was diluted with 100mL water and extracted three times with ethyl acetate. The ethyl acetate extracts were washed with a saturated NaHCO3 solution, dried over anhydrous MgSO4, and concentrated in vacuo . The residue was purified chromatographically using 35% ethyl acetate in hexane as the eluent to give 2.46g (79%) of 5-(4-chloro-1-methyl- 5-(trifluoromethyl)-1H-pyrazol-3-yl)-2,4-difluoro- benzenamine as a white solid, mp 82ºC.
Anal. Calc. for C11H7Cl1F5N3: C,42.40; H,2.26;
N,13.48.
Found: C,42.40; H,2.26;
N, 13.49.
B. All equipment was flame dried under nitrogen. A solution of 2.0g (6.4 mmole) of the product of step A in 50mL acetonitrile at 25ºC was treated with 0.63g (6.4 mmole) CuCl and 1.2g (9.4 mmole) of CuCl2. A solution of 1.74mL (5.0 mmole) 90% t-butyl nitrite was added over 5 minutes. After 4 hours at 28ºC the
reaction mixture was stripped in vacuo. The reaction residue was taken up in ethyl acetate and washed three times with a 10% HCl solution, two times with brine and dried over anhydrous MgSO4, and concentrated in vacuo . The residue was purified chromatographically using 10% ethyl acetate in hexane as the eluent to give 1.63g (78%) of 4-chloro-3-(5-chloro-2,4-difluorophenyl)-1- methyl-5-(trifluoromethyl)-1H-pyrazole as a white solid, mp 50-51ºC.
Anal. Calc. for C11H5Cl2F5N2: C,39.91; H,1.52;
N,8.46.
Found: C,39.89; H,1.52;
N,8.39.
Examples 20 and 21 describe working embodiments of Process VI.
Example 20
This example describes the preparation of 4- chloro-3-(4-chloro-2-fluoro-5-hydroxyphenyl)-1-methyl- 5-(hydroxyphenyl)-1-methyl-5-(trifluoromethyl)-1H- pyrazole (Compound No. 325).
1.39g of 4-chloro-3-(4-chloro-2-fluoro-5- methoxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole was dissolved in 80ml of anhydrous methylene chloride and then cooled with a dry ice/acetone bath and 0.14ml of boron tribromide added. After allowing to warm to room temperature, the mixture was treated with an additional 0.28 ml of boron tribromide. Added was an additional 1.0ml of boron tribromide and stirred at room temperature for 6 hours. After stirring, 30-50ml of ice cooled water was added and the mixture stirred for 10 minutes. The organic phase was extracted with water, dried with anhydrous magnesium sulfate, filtered and concentrated to give 1.28g of 4-chloro-3-(4-chloro-2- fluoro-5-hydroxyphenyl)-1-methyl-5-(trifluoromethyl)- 1H-pyrazole, m.p. 123.0-126.0ºC.
Anal. Calc. for C11H6N2O1Cl2F4: C,40.15; H,1.84;
N,8.51.
Found: C,40.08; H,1.87;
N,8.48.
Example 21
This example describes the preparation of 4-(4- chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5- fluoro-2-nitrophenol (Compound No. 429).
A solution of 1.4g (4 mmole) 4-chloro-3-(2- fluoro-4-methoxy-5-nitrophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole in 20mL methylene chloride was chilled to 0ºC. Next 5.0mL of a 1M methylene chloride solution of BBr3 (4.9 mmole) was added slowly over 10 minutes. The solution was allowed to stir overnight at room temperature . The solution was washed two times with water , dried over anhydrous MgSO4, and concentrated in vacuo . The residue was recrystallized from hexane to give 0.7g (54%) of 4-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-fluoro-2-nitrophenol as a beige solid, mp 89-90ºC. Anal. Calc. for C11H6Cl1F4N3O3: C,38.90; H,1.78;
N,12.37.
Found: C,38.93; H,1.78;
N,12.16.
Examples 22 through 24 describe specific working embodiments of Process VII.
Example 22
This example describes the preparation of 4- chloro-3-(4-chloro-2-fluoro-5-progargyloxyphenyl)-1- methyl-5-(trifluoromethyl)-1H-pyrazole (Compound No.
261).
1.01g of 4-chloro-3-(4-chloro-2-fluoro-5- hydroxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole, 0.44g of anhydrous potassium carbonate and 0.5 mL of propargyl bromide (80% by wt. in toluene) were dissolved in 20-30 mL of anhydrous DMF. The mixture was heated at 65ºC for 90 minutes. After cooling, the mixture was diluted with water and then extracted three times with ether. The combined ether extracts were extracted twice with water, dried with anhydrous magnesium sulfate, filtered, concentrated and chromatographed to give 1.05g of 4-chloro-3-(4-chloro-2-fluoro-5-progargyloxyphenyl)- 1-methyl-5-(trifluoromethyl)-1H-pyrazole, mp.
89.5-91.0ºC.
Anal. Calc. for C14H8N2O1Cl2F4: C,45.80%; H,2.20%;
N,7.63%.
Found: C,45.93%; H,2.21%;
N,7.61%.
Example 23
This example describes the preparation of (4- (4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3- yl)-5-fluoro-2-nitrophenoxy)acetic acid, ethyl ester (Compound No. 386).
At 25ºC, 6.11g (0.018 mole) 4-(4-chloro-1- methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-fluoro-2- nitrophenol, 2.5g (0.019 mole) K2CO3, and 2.0mL (0.019 mole) ethyl bromoacetate were slurried in 100mL acetone. The reaction mixture was stirred at 40ºC for 4 hours. The mixture was cooled, diluted with 100mL cold water, and extracted four times with ethyl acetate. The ethyl acetate extracts were washed with brine, dried over anhydrous MgSO4, and stripped in vacuo . The residue was recrystallized from methylcyclohexane to give 7.5g (99%) of (4-(4-chloro-1-methy1-5-(trifluoromethyl)-1H- pyrazol-3-yl)-5-fluoro-2-nitrophenoxy)acetic acid, ethyl ester as a light yellow solid, mp 95-96ºC.
Anal. Calc. for C15H12Cl,F4N3O5: C,42.32; H,2.84;
N,9.87.
Found: C,42.30; H,2.83;
N,9.85.
Example 24
This example describes the preparation of (2- chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-4-fluorophenoxy)acetic acid, ethyl ester (Compound No. 290).
At 25ºC, 13.16g (0.04 mole) 4-chloro-3-(4- chloro-2-fluoro-5-hydroxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole, 6.1g (0.044 mole) K2CO3, and 4.8mL (0.044 mole) ethyl bromoacetate were slurried in 25 mL acetone. The reaction mixture was stirred at 25ºC for 16 hours. The reaction solution was poured into 150mL ice water, filtered, washed with water and air dried. The residue was recrystallized from hexane to give 16.6g (100%) of (2-chloro-5-(4-chloro-1-methyl-5-(trifluoro- methyl)-1H-pyrazol-3-yl)-4-fluorophenoxy)acetic acid, ethyl ester as a white solid, mp 130-131ºC.
Anal. Calc. for C15H12Cl2F4N2O3: C43.40; H,2.91;
N,6.75.
Found: C,43.54; H,2.91;
N,6.77.
Examples 25 and 26 describe specific working embodiments of Process VIII. Examole 25
This example describes the preparation of 2-(2- chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-4-fluorophenoxy)-N-methyl-propanamide (Compound No. 237).
A. To a slurry of 1.4g (3.3 mmole) 2-(2-chloro- 5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3- yl)-4-fluorophenoxy)-propanoic acid, ethyl ester in 50mL water and 30mL 1,4-dioxane was added 1.3mL (3.3 mmole) of a 10% NaOH solution. After 30 minutes, the solution was cooled and the pH adjusted to 3 with concentrated HCl. The reaction mixture was extracted with diethyl ether. The ether solution was washed with water, dried over anhydrous MgSO4, and concentrated in vacuo . The residue was recrystallized from methylcyclohexane to give 1.3g (100%) of 2-(2-chloro-5-(4-chloro-1-methyl-5- (tri-fluoromethyl)-1H-pyrazol-3-yl)-4-fluorophenoxy)- propanoic acid as a white solid, mp 150-151ºC.
Anal. Calc. for C14H10Cl2F4N2O3: C,41.92; H,2.51;
N,6.98.
Found: C,41.96; H,2.48;
N,7.00.
B. To a solution of 0.8g (2.0 mmole) of the product of step A in 100mL methylene chloride was added 0.5mL (6.0 mmole) oxalyl chloride over 5 minutes, causing the evolution of gas. When this evolution ceased, one drop of DHF was added and the solution stirred until the gas evolution ceased. The solution was stripped to dryness in vacuo . The residue was dissolved in 10mL THF and added to a solution of 5mL 40% aqueous methyl amine and 10mL THF at 0ºC over 5 minutes. The reaction mixture was allowed to stir for 30 minutes at room temperature. The solution was diluted with 100mL cold water and extracted with ethyl acetate. The ethyl acetate was washed with brine, dried over anhydrous MgSO4 and concentrated in vacuo . The solid was recrystallized from methylcyclohexane to give 0.83g (99%) of 2-(2-chloro-5-(4-chloro-1-methyl-5-(trifluoro- methyl)-1H-pyrazol-3-yl)-4-fluorophenoxy)-N-methyl- propanamide as a white solid, mp 134.5-135.5ºC.
Anal. Calc. for C15H13Cl2F4N3O2: C,43.50; H,3.16;
N,10.16.
Found: C, 43.70; H,3.16;
N,10.20.
Example 26
This example describes the preparation of 2-(2- chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-4-fluorophenoxy)propanoic acid, 3-methyl- butyl ester (Compound No. 288).
To a solution of 1.9g (5.0 mmole) of 2-(2- chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-4-fluorophenoxy)-propanoic acid in 50mL methylene chloride was added 1.3mL (15.0 mmole) oxalyl chloride over 5 minutes, causing the evolution of gas. When this evolution ceased, one drop of DMF was added and the solution stirred until the gas evolution ceased. The solution was stripped to dryness in vacuo . The acid chloride was dissolved in 40mL of 3-methyl-1-butanol and heated to reflux for one hour. The reaction mixture was cooled, diluted with 100mL cold water and extracted with ethyl acetate. The ethyl acetate was washed with brine, dried over anhydrous MgSO4 and concentrated in vacuo . The residue was purified chromatographically using 25% ethyl acetate in hexane as the eluent to give 2.17g (95%) of 2-(2-chloro-5-(4-chloro-1-methyl-5- (trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorophenoxy)-propanoic acid, 3-methylbutyl ester as a white solid; mp 128ºC. Anal. Calc. for C18H18Cl2F4N2O3: C,47.28; H,3.97;
N,6.13.
Found: C,47.32; H,3.95;
N,6.17. Example 27
This example describes the preparation of 2H- 1,4-benzoxazin-3(4H)-one, 6-(4-chloro-1-methyl-5-(tri- fluoromethyl)-1H-pyrazol-3-yl)-7-fluoro-4-(2-propynyl)- 2H-1,4-benzoxazin-3(4H)-one (Compound No. 446) and is a specific embodiment of Process IX.
A. A solution of 4.5g (0.0106 mole) (4-(4- chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5- fluoro-2-nitrophenoxy)-acetic acid, ethyl ester in 75mL acetic acid was heated to 80ºC under a nitrogen
atmosphere. The heat and nitrogen were removed and 1.8g (0.033 mole) iron powder was added in 3 portions over 5 min. The solution was stirred at 80ºC for an additional 3 hours. The solution was cooled and filtered through Celite®. The filtrate was diluted with 100mL water and extracted three times with ethyl acetate. The ethyl acetate extracts were washed with a saturated NaHCO3 solution, dried over anhydrous MgSO4, and concentrated in vacuo. The residue was recrystallized from methylcyclo- hexane/ethyl acetate to give 2.95g (80%) of 6-(4-chloro- 1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-fluoro- 2H-1,4-benzoxazin-3(4H)-one as a white solid, mp 207ºC. Anal. Calc. for C13H8Cl1F4N3O2: C,44.65; H,2.31;
N,12.02.
Found: C,44.66; H,2.31;
N,11.97.
B. At 25ºC, 3.0g (8.6 mmole) of the product of step A, 1.22g (6.0 mmole) K2CO3 and 0.79mL (8.8 mmole) 80% propargyl bromide were slurried in 50mL acetone.
The reaction was stirred at 40ºC for 6 hours. The reaction was cooled, diluted with 100mL cold water, and extracted four times with ethyl acetate. The ethyl acetate extracts were washed with brine, dried over anhydrous MgSO4, and stripped in vacuo . The residue was recrystallized from methylcyclohexane to give 2.97g (89%) of 2H-1,4-benzoxazin-3(4H)-one, 6-(4-chloro-1- methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-fluoro-4- (2-propynyl)-2H-1,4-benzoxazin-3(4H)-one as a beige solid, mp 142-143ºC. Anal. Calc. for C16H10Cl1F4N3O2: c,49.57; H,2.60;
N, 10.84.
Found: C,49.58; H,2.62;
N, 10.85.
Example 28
This example describes the preparation of 7- (4- chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-6- fluoro-4-(2-propynyl)-2H-1,4-benzoxazin-3(4H)-one
(Compound No. 479) and is a specific embodiment of
Process X.
A. A solution of 2.3g (5.4 mmole) (5-(4-chloro- 1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluoro- 2-nitrophenoxy) acetic acid, ethyl ester in 50mL acetic acid was heated to 80ºC under a nitrogen atmosphere.
The heat and nitrogen were removed and 0.9g (16.2 mmole) iron powder was added in 3 portions over 5 minutes. The solution was stirred at 80ºC for an additional 50 minutes. The solution was cooled and filtered through Celite®. The filtrate was diluted with 100mL water and extracted three times with ethyl acetate. The ethyl acetate extracts were washed with a saturated NaHCO3 solution, dried over anhydrous MgSO4 and concentrated in vacuo . The residue was recrystallized from methylcyclo- hexane/ethyl acetate to give 0.96g (50%) of 7-(4-chloro- 1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-6-fluoro- 2H-1,4-benzoxazin-3(4H)-one as a white solid, mp 242ºC. Anal. Calc. for C13H8Cl1F4N3O2: C,44.65; H,2.31;
N,12.02.
Found: C,44.61; H,2.27;
N, 11.99.
B. At 25'C, 2.7g (7.7 mmole) the product of step A, 1.1g (8.0 mmole) K2CO3 and 0.9mL (8.0 mmole) 80% propargyl bromide were slurried in 25 mL DMSO. The mixture was stirred at 45ºC for 16 hours. The mixture was cooled, diluted with 100mL cold water and extracted four times with ethyl acetate. The ethyl acetate extracts were washed with brine, dried over anhydrous MgSO4 and stripped in vacuo . The residue was purified chromatographically using methylene chloride as the eluent to give 2.7g (90%) of 7-(4-chloro-1-methyl-5- (trifluoromethyl)-1H-pyrazol-3-yl)-6-fluoro-4-(2- propynyl)-2H-1,4-benzoxazin-3(4H)-one as a white solid, mp 184ºC.
Anal. Calc. for C16H10Cl1F4N3O2: C,49.57; H,2.60;
N, 10.84.
Found: C,49.48; H,2.56;
N, 10.95.
Example 29
This example describes the preparation of cis- and trans-4-chloro-3-(3-(chloromethylene)-5-fluoro-2,2- dihydro-6-benzofuranyl)-1-methyl-5-(trifluoromethyl)- 1H-pyrazole (Compound Nos. 481 and 482) and is a
specific embodiment of Process XI.
All equipment was flame dried under nitrogen. A solution of 2.0g (5.75 mmole) 4-(4-chloro-1-methyl-5- (trifluoromethyl)-1H-pyrazol-3-yl)-5-fluoro-2-(2-pro- pynloxy)-benzeneamine in 100mL acetonitrile at 25ºC was treated with 0.6g (5.75 mmole) CuC1 and 0.8g (5.75 mmole) CuCl2. A solution of 1.1mL (8.6 mmole) 90% t- butyl nitrite was added over 5 minutes. After 6 hours at 28ºC the reaction mixture was stripped in vacuo. The reaction residue was taken up in ethyl acetate and washed three times with a 10% HCl solution, two times with brine and dried over anhydrous MgSO4 and concentrated in vacuo . The residue was purified chromatographically using 20% ethyl acetate in hexane as the eluent to give 0.73g (35%) of cis-4-chloro-3-(3- (chloromethylene)-5-fluoro-2,3-dihydro-6-benzofuranyl)- 1-methyl-5-(trifluoromethyl)-1H-pyrazole as a white solid, mp 140.5-142.5ºC.
Anal. Calc. for C14H8Cl2F4N2O1: C45.80; H,2.20;
N,7.63; Cl,19.31.
Found: C,45.64; H,2.22;
N,7.60; Cl,19.29.
The chromatography described above gave a second fraction following the main component. This fraction was collected, stripped and the residue crystallized from hexanes to give 0.68g (32% yield) of trans-4- chloro-3-(3-(chloromethylene)-5-fluoro-2,3-dihydro-6- benzo-furanyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole as a beige solid, mp 132-135ºC.
Anal. Calc. for C14H8Cl2F4N2O1: C,45.80; H,2.20;
N,7.63; Cl,19.31.
Found: C,45.71; H,2.23;
N,7.63; Cl, 19.28.
Examples 30 through 37 describe working embodiments of Process XII.
Example 30
This example describes the preparation of 3-[5- (bromomethyl)-4-chloro-2-fluorophenyl]-4-chloro-1- methyl-5-(trifluoromethyl)-1H-pyrazole (Compound No. 108).
A slurry of 3-[5-methyl-4-chloro-2-fluorophenyl]-4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazole (25g, 76.4mmole) and N-bromosuccinimide (13.6g, 76.4mmole) in 100ml of carbon tetrachloride in a 500ml round bottomed flask equipped with a magnetic stirrer was treated with a catalytic amount of benzoul peroxide. The temperature was raised to reflux for one hour. The reaction mixture was cooled to room temperature, filtered and concentrated to give 31.5g of white solid. The material was recrystallized twice from hexanes to afford 15.3g (49%) of 3-[5-(bromomethyl)-4-chloro-2- fluorophenyl]-4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazole as a white solid; mp 112-114ºC.
Anal. Calc. for C12H7N2F4Cl2Br1 : C,35.50; H,1.74;
N,6.90.
Found: C,35.57; H,1.76;
N,6.88.
Example 31
This example describes the preparation of (((2- chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-4-fluorophenyl)methyl)thio)acetic acid, ethyl ester (Compound No. 123).
A mixture of 1.62g (4.0 mmole) 3-[5-(bromomethyl)-4-chloro-2-fluorophenyl]-4-chloro-1-methyl-5- (trifluoromethyl)-1H-pyrazole, 0.44mL ethyl mercaptoacetate and 0.55g K2CO3 was slurried in 25mL of acetone. The reaction mixture was allowed to stir at room
temperature overnight. After dilution with 100mL of cold water, the mixture was extracted with ethyl
acetate, the organic extracts washed with water, dried with MgSO4 and concentrated in vacuo . The residue was purified by chromatography to afford l.7g (96%) of (((2- chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-4-fluorophenyl)methyl)thio)acetic acid, ethyl ester as a white solid; mp 63ºC.
Anal. Calc. for C16H14Cl2F4N2O2S1 : C,43.16; H,3.17;
N,6.29.
Found: C,43.16; H,3.16;
N,6.27.
Example 32
This example describes the preparation of 2- chloro-5-[4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl]-4-fluorobenzenemethanol (Compound No.
122).
To a solution of 7.1g (0.0175 mole) 3-[5- (bromomethyl)-4-chloro-2-fluorophenyl]-4-chloro-1- methyl-5-(trifluoromethyl)-1H-pyrazole in 20mL DMF was added 1.5g (0.018 mole) sodium acetate. The mixture was stirred for 12 hours at 25ºC. The mixture was poured into 100mL cold water and the solid filtered and dried. The product was recrystallized from ethanol/-water to give 6.0g (90%) of 2-chloro-5-(4-chloro-1-methyl-5- (trifluoromethyl)-1H-pyrazol-3-yl)-4-fluoro- benzenemethanol, acetate (ester), mp 90ºC. The acetate was dissolved in 10mL 1,4-dioxane and 10mL water and 6.3mL (0.0158 mole) 10% NaOH solution was added. After 30 minutes the solution was neutralized with concentrated HCl, filtered and the solid dried. The solid was recrystallized from ethanol/water to give 5.4g (99%) of 2-chloro-5-[4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl]-4-fluorobenzenemethanol as a white solid; mp 103ºC.
Anal. Calc. for C12H8N2O1F4Cl2: C,42.01; H,2.35;
N,8.16.
Found: C,41.88; H,2.34;
N,8.09. Example 33
This example describes the preparation of ((2- chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-4-fluorophenyl)methoxy)acetic acid, 1- methylethylester (Compound No. 119).
At 25ºC, 1.7g (5.0 mmole) 2-chloro-5-[4-chloro- 1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-4-fluoro- benzenemethanol, 0.8g (5.5 mmole) K2CO3 and 0.7mL (5.5 mmole) isopropyl bromoacetate were slurried in 15mL DMSO. The mixture was stirred overnight at 45ºC. The mixture was cooled, diluted with 100mL cold water and extracted four times with ethyl acetate. The ethyl acetate extracts were washed with brine, dried over anhydrous MgSO4 and stripped in vacuo . The residue was purified chromatographically using 10% ethyl acetate in hexane as the eluent to give 0.9g (41%) of ((2-chloro- 5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3- yl)-4-fluorophenyl)methoxy)acetic acid, 1-methylethyl ester as a white solid; mp 55ºC.
Anal. Calc. for C17H16Cl2F4N2O3: C46.07; H,3.64;
N,6.32.
Found: C,46.21; H,3.69;
N,6.11. Example 34
This example describes the preparation of 4- chloro-3-[4-chloro-5-(dibromomethyl)-2-fluorophenyl]-1- methyl-5-(trifluoromethyl)-1H-pyrazole (Compound No.
132).
In a 250ml round bottomed flask equipped with a magnetic stirrer, a slurry of 3-[5-methyl-4-chloro-2- fluorophenyl]-4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazole (8.18g, 25mmole) and N-bromosuccinimide (8.9g, 50.0mmole) was prepared in 50ml of carbon tetrachloride. A catalytic amount of benzoyl peroxide was added and the temperature was raised to reflux and held for 3.5 hours. The reaction mixture was cooled to room temperature, filtered and concentrated. The residue was purified by chroma-tography to afford 10.36g (85%) of 4-chloro-3- [4-chloro-5-(dibromomethyl)-2-fluorophenyl]-1-methyl-5- (tri-fluoromethyl)-1H-pyrazole as a white solid; mp 89- 92ºC.
Anal. Calc. for C12H6N2F4Cl2Br2; C,29.72; H,1.25;
N,5.78.
Found: C,29.72; H,1.25;
N,5.78.
Example 35
This example describes the preparation of 2- chloro-5-[4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl]-4-fluorobenzaldehyde (Compound No. 133).
In a 100ml round bottomed flask equipped with a magnetic stirrer, 4-chloro-3-[4-chloro-5-(dibromo- methyl)-2-fluorophenyl]-1-methyl-5-(trifluoromethyl)-
1H-pyrazole (5.0g, 10.3mmole) was stirred for 30 minutes in 20ml of sulfuric acid. The resulting clear yellow solution was allowed to stand at room temperature for 10 days, stirred briefly to remove color, and poured onto 200ml of ice/water. The aqueous mixture was extracted with ether and the organic layer was dried with MgSO4, filtered and concentrated to give 3.15g of white solid which was recrystallized from cold hexanes to afford 2.5g (71%) of 2-chloro-5-[4-chloro-1-methyl-5- (trifluoromethyl)-1H-pyrazol-3-yl]-4-fluorobenzaldehyde as a white solid; mp 70-72ºC.
Anal. Calc. for C12H6N2O1F4Cl2: C,42.26; H,1.77;
N,8.21.
Found: C,42.22; H,1.78;
N,8.24. Example 36
This example describes the preparation of 2- chloro-5-[4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl]-4-fluorobenzoic acid (Compound No. 149).
To a solution of 2-chloro-5-[4-chloro-1-methyl- 5-(trifluoromethyl)-1H-pyrazol-3-yl]-4-fluorobenzalde- hyde (4.5g, 13.2mmole) in 40ml of acetone was added 13ml (26mmole) of Jones' reagent. The solution was stirred at ambient temperature for 2 hours and poured into 400ml of water. The resulting solid was filtered and air dried overnight to afford 4.5g (96%) of 2-chloro-5-[4- chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-4- fluoro-benzoic acid as a white solid. An analytical sample was recrystallized from ether/hexanes; mp 179- 181ºC.
Anal. Calc. for C13H6N2O2F4Cl2: C,40.36; H,1.69;
N,7.84.
Found: C,40.49; H,1.74;
N,7.77. Example 37
This example describes the preparation of 2- chloro-5-[4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl]-4-fluorobenzoic acid, 1-methylethyl ester (Compound No. 135).
To a solution of 4.3g (0.012 mole) 2-chloro-5-
(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3- yl)-4-fluorobenzoic acid in 50mL methylene chloride was added 3.1mL (0.036 mole) oxalyl chloride causing the evolution of gas. When this evolution ceased, one drop of DMF was added and the solution stirred until the gas evolution ceased. The solution was concentrated in vacuo and the resultant residue dissolved in 25mL iso- propanol and heated to 60ºC for 1 hour. The solution was cooled, poured into 200mL cold water and the solid filtered and dried. The product was recrystallized from ethanol/water to yield 1.69g (70%) of 2-chloro-5-[4- chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-4- fluorobenzoic acid, 1-methylethyl ester as a white solid; mp 69ºC.
Anal. Calc. for C15H12Cl2F4N2O2: C,45.13; H,3.03;
N,7.02.
Found: C,45.14; H,3.04;
N,7.03.
Examples 38 and 39 describe working embodiments of Process XIII.
Example 38
This example describes the preparation of 2- chloro-5-[4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl]-4-fluorobenzenesulfonyl chloride (Compound No. 346).
A solution of 4-chloro-3-(4-chloro-2- fluorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole in 20mL of chlorosulfonic acid was heated in a 120ºC oil bath for four hours and allowed to cool to room
temperature. Methylene chloride was added and the solution added dropwise to a stirring mixture of ice and water (caution, extremely reactive). The layers were separated and the aqueous layer was washed with
methylene chloride. The combined organic layers were dried with MgSO4, filtered and concentrated and the resultant solid residue washed with a very small amount of ether and recrystallized from hexanes to afford 1.65g (63%) of 2-chloro-5-[4-chloro-1-methyl-5-(trifluoro- methyl)-1H-pyrazol-3-yl]-4-fluorobenzenesulfonyl chloride as a white solid; mp 116-117ºC.
Anal. Calc. for C11H5N2O2S1F4Cl3: C,32.10; H,1.22;
N,6.81; Cl,25.84.
Found: C,32.15; H,1.17;
N,6.76; Cl,25.77.
Example 39
This example describes the preparation of 2- chloro-5-[4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl]-4-fluorobenzenethiol (Compound No. 343).
To a solution of 12.8g (0.031 mole) 2-chloro-5 [4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3- yl]-4-fluorobenzenesulfonyl chloride in 100mL acetic acid was added 40.7g (0.62 mole) zinc powder. The slurry was stirred at 80ºC for 4 hours, allowed to cool and filtered through Celite®. The filtrate was poured into 1.0 L water, the solid filtered and dried. The solid was recrystallized from ethanol/water to give 10.2g (95%) of 2-chloro-5-[4-chloro-1-methyl-5-
(trifluoromethyl)-1H-pyrazol-3-yl]-4-fluorobenzenethiol as a yellow solid; mp 56-58ºC.
Anal. Calc. for C11H6N2S1F4Cl2: C,38.28; H,1.75;
N,8.12.
Found: C,38.29; H,2.02;
N,8.12.
Example 40
This example describes the preparation of 4- chloro-3-(4-chloro-5-(1,3-dioxolan-2-yl)-2- fluorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole (Compound No . 100 ) and is a specific embodiment of Process XIV.
In an apparatus equipped with a Dean-Stark trap for azeotropic removal of water, 2.4g (7.0 mmoles) 2- chloro-5-[4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl]-4-fluorobenzaldehyde, 0.4mL (7.7 mmoles) ethylene glycol and a catalytic amount of p-toluene- sulfonic acid in 50mL toluene was heated to reflux for 24 hours. The resultant mixture was concentrated and the residue purified by chromatography to give 1.65g (61%) of 4-chloro-3-(4-chloro-5-(1,3-dioxolan-2-yl)-2- fluorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole as a clear colorless oil; 1.5348.
Anal. Calc. for C14H10Cl2F4N2O2: C,43.66; H,262;
N,7.27.
Found: C,43.67; H,2.59;
N, 7.24.
Example 41
This example describes the preparation of 3-(2- chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-4-fluorophenyl)propenoic acid, methyl ester (Compound No. 128) and is a specific embodiment of Process XV.
To a solution of 2.3g (6.8 mmole) 2-chloro-5- [4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3- yl]-4-fluorobenzaldehyde in 25mL methanol was added 2.27g (6.8mmole) methyl(triphenylphosphoranylidene)- acetate, keeping the temperature below 35ºC. The reaction mixture was allowed to stir for 15 minutes and diluted with ethyl acetate, washed with brine, dried over anhydrous MgSO4, and concentrated in vacuo . The residue was purified chromatographically using 20% ethyl acetate in hexane as the eluent to give 2.0g (74%) of 3- (2-chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-4-fluorophenyl) propenoic acid, methyl ester as a white solid; mp 117ºC.
Anal. Calc. for C15H10Cl2F4N2O2: C45.36; H,2.54;
N,7.05.
Found: C,45.41; H,2.59;
N,7.03. Example 42
This example describes the preparation of ((((2- chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-4-fluorophenyl)methylene)amino)oxy)acetic acid (Compound No. 130) and is a specific embodiment of Process XVI.
A mixture of 3.4g (0.01 mole) 2-chloro-5-[4- chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-4- fluorobenzaldehyde, 2.73g (0.0125 mole) carboxymethoxyl- amine hemihydrochloride and 1.03g (0.0125 mole) sodium acetate in 50mL ethanol was heated to reflux for 2 hours. The reaction mixture was allowed to cool, treated with 150mL of water and the resultant precipitate collected and dried. The product was recrystal- lized from methylcyclohexane with a minimum amount of ethyl acetate to yield 3.35g (81%) of ((((2-chloro-5- (4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3- yl)-4-fluorophenyl)methylene)amino)oxy)acetic acid as a white solid; mp 170ºC.
Anal. Calc. for C14H19Cl2F4N3O3: C,40.60; H,2.19;
N,10.15.
Found: C,40.54; H,2.28;
N,10.17. Tables 4-6 show examples of compounds prepared according to Processes II-XVI. In Table 4 are listed examples of 1-methyl-5-arylpyrazole compounds. In Table 5 are examples of 1-methyl-3-arylpyrazoles. Table 6 lists a variety of compounds, most of which include compounds wherein R6 and R7 are cyclized to form fused- ring heterocyclic structures.
2 3
In Table 6 are listed various other compounds according to Formula I whose structures do not conveniently fit into Tables 4 and 5.
2
PRE-EMERGENCE HERBICIDE TESTS
As noted above, the compounds of this invention have been found to be surprisingly effective as herbicides.
The tests for pre-emergence herbicide activity are conducted as follows:
Topsoil is placed in an aluminum pan and compacted to a depth of 0.95 to 1.27 cm from the top of the pan. On the top of the soil is placed a predetermined number of seeds of each of several monocotyledonous and dicotyledonous annual plant species and/or vegetative propagules of various perennial plant species. A known amount of the active ingredient dissolved or suspended in an organic solvent, e.g., acetone, or water as carrier is then applied directly to the seed bed, which is then covered with a layer of untreated topsoil to level fill the pan. After treatment, the pans are moved to a greenhouse bench where they are watered from below as needed to give adequate moisture for germination and growth.
Approximately 10-14 days (usually 11 days) after seeding and treating, the pans are observed and the results (% inhibition) are recorded.
Tables 7 and 7A below summarize the results of the pre-emergence herbicidal activity tests of compounds of this invention in weeds. The herbicidal rating shown in these tables is the percent inhibition of each plant species. The plant species usually regarded as weeds which are utilized in one set of tests, the data for which are shown in the tables, are identified by letter headings above the columns in accordance with the following legend: Yens - Yellow nutsedge
Anbg - Annual bluegrass
Sejg - Seedling johnsongrass
Dobr - Downy Brome
Bygr - Barnyardgrass
Mogl - Morningglory
Cobu - Cocklebur
Vele - Velvetleaf
Inmu - Indian Mustard
Wibw - Wild buckwheat
Where noted in the tables below, the symbol 'C" represents 100% control and the symbol "N" indicates that the species was planted, but no data obtained for one reason or another. Compound Nos. 1-61 are
intermediate compounds and do not appear in Tables 7 and 8 below.
* Poor germanation- Wibw.
@ Cocklebur germination eratic
+ Excessive damping off
( Sejg germination was thin.
) FREQUENT DAMPING OFF-Inmu, Wibw
POST-EMERGENCE HERBICIDE TESTS
The post-emergence herbicidal activity of some of the various compounds of this invention was demonstrated by greenhouse testing in the following manner. Topsoil is placed in aluminum pans having holes in the bottom and compacted to a depth of 0.95 to 1.27 cm from the top of the pan. A predetermined number of seeds of each of several dicotyledonous and monocotyledonous annual plant species and/or vegetative propagules for the perennial plant species are placed on the soil and pressed into the soil surface. The seeds and/or
vegetative propagules are covered with soil and leveled. The pans are then placed on a bench in the greenhouse and watered from below as needed. After the plants reach the desired age (two to three weeks), each pan, is removed individually to a spraying chamber and sprayed by means of an atomizer, operating at a spray pressure of 170.3 kPa (10 psig) at the application rates noted. In the spray solution is an amount of an emulsifying agent mixture to give a spray solution or suspension which contains about 0.4% by volume of the emulsifier. The spray solution or suspension contains a sufficient amount of the candidate chemical in order to give application rates of the active ingredient corresponding to those shown in Tables 8 and 8A, while applying a total amount of solution or suspension equivalent to 1870 L/Ha (200 gallons/acre). The pans were returned to the greenhouse and watered as before and the injury to the plants as compared to the control is observed at approximately 10-14 days (usually 11 days) and in some instances observed again at 24-28 days (usually 25 days) after spraying. The post-emergent herbicidal activity shown in these tables is the percent inhibition of each plant species.
The herbicidal compositions of this invention, including concentrates which require dilution prior to application, may contain at least one active ingredient and an adjuvant in liquid or solid form. The compositions are prepared by admixing the active ingredient with an adjuvant including diluents, extenders,
carriers, and conditioning agents to provide compositions in the form of finely-divided particulate solids, granules, pellets, solutions, dispersions or emulsions. Thus, it is believed that the active ingredient could be used with an adjuvant such as a finely-divided solid, a liquid of organic origin, water, a wetting agent, a dispersing agent, an emulsifying agent or any suitable combination of these.
Suitable wetting agents are believed to include alkyl benzene and alkyl naphthalene sulfonates, sulfated fatty alcohols, amines or acid amides, long chain acid esters of sodium isothionate, esters of sodium
sulfosuccinate, sulfated or sulfonated fatty acid esters, petroleum sulfonates, sulfonated vegetable oils, ditertiary acetylenic glycols, polyoxyethylene
derivatives of alkylphenols (particularly isooctylphenol and nonylphenol) and polyoxyethylene derivatives of the mono-higher fatty acid esters of hexitol anhydrides (e.g., sorbitan). Preferred dispersants are methyl cellulose, polyvinyl alcohol, sodium lignin sulfonates, polymeric alkyl naphthalene sulfonates, sodium
naphthalene sulfonate, and polymethylene bisnaphthalene sulfonate. Wettable powders are water-dispersible compositions containing one or more active ingredients, an inert solid extender and one or more wetting and dispersing agents. The inert solid extenders are usually of mineral origin such as the natural clays, diatomaceous earth and synthetic minerals derived from silica and the like. Examples of such extenders include kaolinites, attapulgite clay and synthetic magnesium silicate. The wettable powders compositions of this invention usually contain from above 0.5 to 60 parts (preferably from 5-20 parts) of active ingredient, from about 0.25 to 25 parts (preferably 1-15 parts) of wetting agent, from about 0.25 to 25 parts (preferably 1.0-15 parts) of dispersant and from 5 to about 95 parts (preferably 5-50 parts) of inert solid extender, all parts being by weight of the total composition. Where required, from about 0.1 to 2.0 parts of the solid inert extender can be replaced by a corrosion inhibitor or anti-foaming agent or both.
Other formulations include dust concentrates comprising from 0.1 to 60% by weight of the active ingredient on a suitable extender; these dusts may be diluted for application at concentrations within the range of from about 0.1-10% by weight.
Aqueous suspensions or emulsions may be prepared by stirring a nonaqueous solution of a water-insoluble active ingredient and an emulsification agent with water until uniform and then homogenizing to give stable emulsion of very finely divided particles. The
resulting concentrated aqueous suspension is characterized by its extremely small particle size, so that when diluted and sprayed, coverage is very uniform.
Suitable concentrations of these formulations contain from about 0.1-60%, preferably 5-50% by weight of active ingredient, the upper limit being determined by the solubility limit of active ingredient in the solvent. Concentrates are usually solutions of active ingredient in water-immiscible or partially water-immiscible solvents together with a surface active agent. Suitable solvents for the active ingredient of this invention include dimethylformamide, dimethylsulfoxide, N-methyl- pyrrolidone, hydrocarbons, and water-immiscible ethers, esters, or ketones. However, other high strength liquid concentrates may be formulated by dissolving the active ingredient in a solvent then diluting, e.g., with kerosene, to spray concentration. The concentrate compositions herein generally contain from about 0.1 to 95 parts (preferably 5-60 parts) active ingredient, about 0.25 to 50 parts
(preferably 1-25 parts) surface active agent and where required about 5 to 94 parts solvent, all parts being be weight based on the total weight of emulsifiable oil.
Granules are physically stable particulate compositions comprising active ingredient adhering to or distributed through a basic matrix of an inert, finely- divided particulate extender. In order to aid leaching of the active ingredient from the particulate extender, a surface active agent can be present in the composition. Natural clays, pyrophyllites, illite, and vermiculite are examples of operable classes of
particulate mineral extenders. The preferred extenders are the porous, absorptive, preformed particles such as preformed and screened particulate attapulgite or heat expanded, particulate vermiculite and the finely- divided clays such as kaolin clays, hydrated attapulgite or bentonitic clays. These extenders are sprayed or blended with the active ingredient to form the
herbicidal granules.
The granular compositions of this invention may contain from about 0.1 to about 30 parts by weight of active ingredient per 100 parts by weight of clay and 0 to about 5 parts by weight of surface active agent per 100 parts by weight of particulate clay.
The compositions of this invention can also contain other additaments, for example, fertilizers, other herbicides, other pesticides, safeners and the like used as adjuvants or in combination with any of the above-described adjuvants. Chemicals useful in
combination with the active ingredients of this
invention included, for example, triazines, ureas, sulfonylureas, carbamates, acetamides, acetanilides, uracils, acetic acid or phenol derivatives, thiol- carbamates, triazoles, azolopyrimidines, benzoic acid and its derivatives, nitriles, biphenyl ethers, nitrobenzenes and the like such as:
Heterocyclic Nitrogen/Sulfur Derivatives
2-Chloro-4-ethylamino-6-isopropylamino-s-triazine 2-Chloro-4,6-bis(isopropylamino)-s-triazine
2-Chloro-4,6-bis(ethylamino)-s-triazine
3-Isopropyl-1H-2,1,3-benzothiadiazin-4-(3H)-one 2,2- dioxide
3-Amino-1,2,4-triazole
6,7-Dihydrodipyrido(1,2-:2',1'-c)-pyrazidiinium salt 5-Bromo-3-isopropyl-6-methyluracil
1,1'-Dimethyl-4,4'-bypyridinium
2-(4-Isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3- quinolinecarboxylic acid
Isopropylamine salt of 2-(4-isopropyl-4-methyl-5- oxo-2-imidazolin-2-yl) nicotinic acid
Methyl 6-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2- yl) -m-toluate and methyl 2- (4-isopropyl-4-methyl- 5-oxo-2-imidazolin-2-yl)-p-toluate
Ureas/Sulfonylureas
N-(4-Chlorophenoxy) phenyl-N,N-dimethylurea
N,N-dimethyl-N'-(3-chloro-4-methylphenyl) urea
3-(3,4-dichlorophenyl)-1,1-dimethylurea
1,3-Dimethyl-3-(2-benzothiazolyl) urea
3-(p-Chlorophenyl)-1,1-dimethylurea
1-Butyl-3-(3,4-dichlorophenyl)-1-methylurea
2-Chloro-N[(4-methoxy-6-methyl-1,3,5-triazin-2-yl) aminocarbonyl]-benzenesulfonamide
N-(2-methoxycarbonylphenyl sulfonyl ()-N'-(4,6-bis- difluoromethoxypyrimidin-2-yl)urea
Methyl 2-(((((4,6-dimethyl-2-pyrimidinyl)amino)- carbonyl)amino)sulfonyl) benzoate
Ethyl 1-[methyl 2-(((((4,6-dimethyl-2-pyrimidinyl)- amino)carbonyl)amino)sulfonyl)] benzoate
Methyl-2((4,6-dimethoxy pyrimidin-2-yl)aminocarbonyl)amino sulfonyl methyl) benzoate
Methyl 2-(((((4-methoxy-6-methyl-1,3,5-triazin-2-yl)- amino)carbonyl)amino)sulfonyl) benzoate Carbamates/Thiolcarbamates
2-Chloroallyl diethyldithiocarbamate
S-(4-chlorobenzyl)N,N-diethylthiolcarbamate
Isopropyl N-(3-chlorophenyl) carbamate
S-2,3-dichloroallyl N,N-diisopropylthiolcarbamate S-N,N-dipropylthiolcarbamate
S-propyl N,N-dipropylthiolcarbamate
S-2,3,3-trichloroallyl-N,N-diisopropylthiolcarbamate
Acetamides/Acetanilides/Anilines/Amides
2-Chloro-N,N-diallylacetamide
N,N-dimethyl-2,2-diphenylacetamide
N-(2,4-dimethylthien-3-yl)-N-(1-methoxyprop-2-yl)-2- chloroacetamide
N-(1H-pyrazol-1-ylmethyl-N-(2,4-dimethylthien-3-yl)-2- chloroacetamide
N-(1-pyrazol-1-ylmethyl)-N-(4,6-dimethoxypyrimidin-5- yl)-2-chloroacetamide
N-(2,4-dimethyl-5-[[[(trifluoromethyl)sulfonyl]amino]- phenyl]acetamide
N-Isopropyl-2-chloroacetanilide
N-Isopropyl-1-(3,5,5-trimethylcyclohexen-1-yl)-2- chloroacetamide
2',6'-Diethyl-N-(butoxymethyl)-2-chloroacetanilide 2',6'-Diethyl-N-(2-n-propoxyethyl)-2-chloroacetanilide 2',6'-Dimethyl-N-(1-pyrazol-1-ylmethyl)-2- chloroacetanilide
2',6',Diethyl-N-methoxymethyl-2-chloroacetanilide 2'-Methyl-6'-ethyl-N-(2-methoxyprop-2-yl)-2- chloroacetanilde
2'-Methyl-6'-ethyl-N-(ethoxymethyl)-2-chloro- acetanilide
α , α ,α-Trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine N-(1,1-dimethylpropynyl)-3,5-dichlorobenzamide
Acids/Esters/Alcohols
2,2-Dichloropropionic acid
2-Methyl-4-chlorophenoxyacetic acid
2,4-Dichlorophenoxyacetic acid
Methyl-2-[4-(2,4-dichlorophenoxy)phenoxy]propionate 3-Amino-2,5-dichlorobenzoic acid
2-Methoxy-3,6-dichlorobenzoic acid
2,3,6-Trichlorophenylacetic acid
N-1-naphthylphthalamic acid
Sodium 5-[2-chloro-4-(trifluororaethyl)phenoxy]-2- nitrobenzoate
4,6-Dinitro-o-sec-butylphenol
N-(phosphonomethyl)glycine and its salts
Butyl (R)-2-[4-[(5-(trifluoromethyl)-2-pyridinyl)oxy]- phenoxy] propanoate
Ethers
2,4-Dichlorophenol-4-nitrophenyl ether
2-Chloro-δ,δ,δ-trifluoro-p-tolyl-3-ethoxy-4-nitro- diphenyl ether
5-(2-chloro-4-trifluoromethylphenoxy)-N-methylsulfonyl 2-nitrobenazmide
1'-(Carboethoxy) ethyl 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate
Miscellaneous
2,6-Dichlorobenzonitrile
Monosodium acid methanearsonate
Disodium methanearsonate
2-(2-chlorophenyl)methyl-4,4-dimethyl-3-isoxazolidinone
7-Oxabicyclo (2.2.1) heptane, 1-methyl-4-(1-methylethyl)-2-(2-methylphenylmethoxy)-, exo- Glyphosate and salts thereof.
Fertilizers useful in combination with the active ingredients include, for example, ammonium nitrate, urea, potash and superphosphate. Other useful additaments include materials in which plant organisms take root and grow such as compost, manure, humus, sand and the like.
Herbicidal formulations of the types described above contemplated as within the purview of this invention are exemplified in several illustrative embodiments below. J. . Emulsifiable Concentrates
Weight Percent A. Compound No. 308 11.0
Free acid of complex organic phosphate
or aromatic or aliphatic hydrophabe
base (e.g., GAFAC RE-610, registered
trademark of GAF Corp.) 5.59
Polyoxyethylene/polyoxypropylene block
copolymer with butanol (e.g., Tergitol XH,
registered trademark of Union Carbide
Corp.) 1.11
Phenol 5.34
Monochlorobenzene 76.96
100.00 B. Compound No. 261 25.00
Free acid of complex organic phosphate
of aromatic or aliphatic hydrophobe
base (e.g., GAFAC RE-610) 5.00
Polyoxyethylene/polyoxypropylene block
copolymer with butanol (e.g., Tergitol
XH) 1 . 60
Cyclohexanone 4 . 75 Monochlorobenzene 63 . 65
100 . 00 C. Compound No. 291 12 . 0
Free acid of complex organic phosphate
or aromatic or aliphatic hydrophobe
base (e.g., GAFAC RE-610, registered
trademark of GAF Corp.) 6.0 Polyoxyethylene/polyoxypropylene block
copolymer with butanol (e.g., Tergitol XH,
registered trademark of Union Carbide
Corp.) 1.5
Cyclohexanone 5.5 Monochlorobenzene 75.0
100.00 Weight Percent
D. Compound of No. 229 20.0
Free acid of complex organic phosphate
of aromatic or aliphatic hydrophobe
base (e.g., GAFAC RE-610 5.00
Polyoxyethylene/polyoxypropylene block
copolymer with butanol (e.g., Tergitol
XH) 2.0
Cyclohexanone 5.0 Monochlorobenzene 68.0
100.00
E. Compound No. 312 11.0
Free acid of complex organic phosphate
or aromatic or aliphatic hydrophobe
base (e.g. GAFAC RE-610, registered
trademark of GAF Corp.) 5.59
Polyoxyethylene/polyoxypropylene block
copolymer with butanol (e.g., Tergitol XH,
registered trademark of Union Carbide
Corp.) 1.11
Cyclohexanone 5.34
Monochlorobenzene 76.96
100.00
F. Compound No. 282 25.00
Free acid of complex organic phosphate
of aromatic or aliphatic hydrophobe
base (e.g., GAFAC RE-610 5.00
Polyoxyethylene/polyoxypropylene block
copolymer with butanol (e.g., Tergitol
XH) 1.60
Cyclohexanone 4.75
Monochlorobenzene 63.65
100.00 Weight Percent
II. Flowables
A. Compound No. 261 25.0
Methyl cellulose 0.3
Silica Aerogel 1.5
Sodium lignosulfonate 3.5
Sodium N-methyl-N-oleyl taurate 1.0
Water 67.7
100.00 B . Compound No. 270 45.0
Methyl cellulose .3
Silica aerogel 1.5
Sodium lignosulfonate 3.5
Sodium N-methyl-N-oleyl taurate 1.0
Water 47.7
100.00
C . Compound No. 294 30.0
Methyl cellulose 0.3
Silica Aerogel 1.5
Sodium lignosulfonate 3.5
Sodium N-methyl-N-oleyl taurate 3.0
Water 62.0
100.00D. Compound No. 135 23.0
Methyl cellulose 0.5
Silica Aerogel 2.0
Sodium lignosulfonate 3.5
Sodium N-methyl-N-oleyl taurate 2.0
Water 69.0
100.00 E. Compound No. 148 45.0
Methyl cellulose .3
Silica aerogel 1.5
Sodium lignosulfonate 3.5
Sodium N-methyl-N-oleyl taurate 1.0
Water 47.7
100.00 Weight Percent III. Wettable Powders
A. Compound No. 261 25.0
Sodium lignosulfonate 3.0 Sodium N-methyl-N-oleyl-taurate 1.0
Amorphous silica (synthetic) 71.0
100.0
B. Compound No. 312 45.0
Sodium dioctyl sulfosuccinate 1.25 Calcium lignosulfonate 1.75
Amorphous silica (synthetic) 52.0
100.0
C. Compound No. 237 10.0
Sodium lignosulfonate 3.0 Sodium N-methyl-N-oleyl-taurate 1.0
Kaolinite clay 86.0
100.00
D. Compound No. 463 30.0
Sodium lignosulfonate 3.0 Sodium N-methyl-N-oleyl-taurate 1.0
Kaolin 56.0
Amorphous silica (synthetic) 10.0
100.0
E. Compound No. 446 75.0
Sodium dioctyl sulfosuccinate 1.25
Calcium lignosulfonate 1.75
Kaolin 12.0
Amorphous silica synthetic 10.0
100.00 F. Compound No. 482 15.0
Sodium lignosulfonate 3.0
Sodium N-methyl-N-oleyl-taurate 1.0
Amorphous silica, synthetic 10.0
Kaolinite clay 71.0
100.00 IV. Granules
A. Compound No. 74 15. 0 Dipropylene Glycol 5. 0 Granular attapulgite (20/40 mesh) 80. 0
100. 0
B. Compound No. 390 15. 0 Dipropylene Glycol 5. 0 Diatomaceous earth (20/40) 80. 0
100. 0 C. Compound No. 399 1. 0 Ethylene glycol 5. 0 Methylene blue 0. 1 Pyrophyllite 93. 9
100. 0 D. Compound No. 393 5.0 Ethylene Glycol 5.0 Pyrophyllite (20/40) 90.0
100.0
E. Compound No. 312 15.0 Propylene Glycol 5.0
Granular attapulgite (20/40 mesh) 80.0
100.0
F. Compound No. 324 25.0 Diatomaceous earth (20/40) 75 .0
100 .0
G. Compound No. 261 5 .0 Ethylene glycol 5 .0 Methylene blue 0 .5 Pyrophyllite 94 .5
100 .00
H. Compound No. 262 10 .0 Propylene Glycol 5 .0 Pyrophyllite (20/40) 85 .0
100 .0 Weight Percent V. Suspension Concentrates
A. Compound No. 262 16.0
Nonylphenol ethoxylate 9.5 mole
EO Sterox NJ 13.8
Sodium lignosulfonate (Reax 88B) 12.2
Water 58.0
100.0
B. Compound No. 446 32.5
Potassium salt of napthalene sulfonate
formaldehyde condensate (DAXAD 11 KLS) 9.0 Nonylphenol ethoxylate 10 mole EO
(Igepal CO-660) 9.0
Water 49 . 5
100.0
C. Compound No. 76 10.0
Sodium dioctyl sulfosuccinate Aerosol
OTB 11.0 Castor oil + 36 Ethylene oxide
(FloMo 3G) 11.0
Water 70.0
100.0
D. Compound No. 261 15.0
Nonylphenol ethoxylate 9.5 mole
EO sterox NJ 1.0
Sodium lignosulfonate (Reax 88B) 5.0
Water 79.0
100.0
E. Compound No. 290 30.0
Potassium salt of napthalene sulfonate
formaldehyde condensate (DAXAD 11 KLS) 4.0 Nonylphenol ethoxylate 10 mole EO
(Igepal CO-660) 2.0
Warer 64.0
100.0 Weight Percent F. Compound No. 135 18 .0
Nonylphenol ethoxylate 9.5 mole
EO Sterox NJ 14 .0 Sodium lignosulfonate (Reax 88B) 12 .0 Water 56 .0
100 .0G. Compound No. 148 34 .0
Potassium salt of napthalene sulfonate
formaldehyde condensate (DAXAD aag) 8.0 Nonylphenol ethoxylate 10 mole EO
(Igepal CO-660) 10.0 Water 48.0
100.0 H. Compound No. 482 14.0
Sodium dioctyl sulfosuccinate Aerosol
OTB 3.0 Castor oil + 36 Ethylene oxide
(FloMo 3G) 3.0 Water 80.0
100.0
VI. Liquid Concentrates
A. Compound No. 76 20.0
Xylene 80.0
100.0
B. Compound No. 229 10.0
Xylene 90.0
100.0C. Compound No. 217 25.0
Xylene 75.0
100.0 D. Compound No. 482 15.0
Xylene 85.0
100.0 VII. Microcapsules
A. Compound No. 135 encapsulated in a
polyurea shell wall 4.5
Reax® C-21 1.5
NaCl 5.0
Water 89.0
100.0
B, Compound No. 137 encapsulated in a
polyurea shell wall 20.0
Reax® 88B 2.0
NaNO3 10.0
Xylene 30.0
Water 38.0
100.0 C. Compound No. 138 encapsulated in a
polyurea shell wall 4.8
Reax® 88B 1.2
NaNO3 5.0
Kerosene 20.0 Water 69.0
100.0 D. Compound No. 148 encapsulated in a
urea-formaldehyde polymer shell wall 50.0 Reax® C-21 1.5
NaCl 8.5
Petroleum oil (Aromatic 200) 20.0
Water 20.0
100.0 E. Compound No. 229 encapsulated in a
thiourea-formaldehyde shell
wall 30.0
Reax® C-21 2.0
NaCl 8.0 Xylene 30.0
Water 30.0
100.0 Weight PercentF. Compound No. 261 encapsulated in a
polyurea shell wall 7.5
Reax® 88B 1.5
NaCl 8.0
Aromatic 200 30.0
Water 53.0
100.0 G. Compound No. 308 encapsulated in a
melamine-formaldehyde co- polymeric shell wall 9.0 Reax® 88B 2.0 NaNO3 10.0 Kerosene 40.0 Water 39.0
100. 0
H. Compound No. 446 encapsulated in a
urea-formaldehyde polymeric
shell wall 15.0
Reax® 88B 10.0
NaNO3 8.0
Xylene 42.0
Water 25.0
100.0 I. Compound No. 312 encapsulated in a
polyurea shell wall 22.0
Reax® 88B 2.0
NaCl 8.0
Xylene 35.0
Water 33.0
100. 0 When operating in accordance with the present invention, effective amounts of the compounds of this invention are applied to the soil containing the seeds, or vegetative propagules or may be incorporated into the soil media in any convenient fashion. The application of liquid and particulate solid compositions to the soil can be carried out by conventional methods, e.g., power duster, boom and hand sprayers and spray dusters. The compositions can also be applied from airplanes as a dust or a spray because of their effectiveness at low dosages. The exact amount of active ingredient to be employed is dependent upon various factors, including the plant species and stage of development thereof, the type and condition of soil, the amount of rainfall and the specific compounds employed. In elective pre- emergence application or to the soil, a dosage of from about 0.02 to about 11.2 kg/ha, preferably from about 0.1 to about 5.60 kg/ha, is usually employed. Lower or higher rates may be required in some instances. One skilled in the art can readily determine from this specification, including the above examples, the optimum rate to be applied in any particular case.
The term "soil" is employed in its broadest sense to be inclusive of all conventional "soils" as defined in Webster's New International Dictionary, Second Edition, Unabridged (1961). Thus, the term refers to any substance or medium in which vegetation may take root and grow, and includes not only earth but also compost, manure, muck, humus, loam, silt, mire, clay, sand and the like, adapted to support plant growth.
Although this invention has been described with respect to specific embodiments, the details of these embodiments are not to be construed as limitations.
Various equivalents, changes and modifications may be made without departing from the spirit and scope of this invention, and it is understood that such equivalent embodiments are part of this invention.

Claims (45)

WE CLAIM :
1. Compounds according to Formula I:
and agriculturally-acceptable salts and hydrates thereof wherein
R1 is independently C1-8 alkyl; C3-8 cycloalkyl, cycloalkenyl, cycloalkylalkyl, or cycloalkenylalkyl; C2-8 alkenyl or alkynyl; benzyl; and said R1 members substituted with halogen, amino, nitro, cyano, hydroxy, alkoxy, alkylthio,
X YR8, - R9, YR10, or NR11R12;
R2 is C1-5 haloalkyl;
R3 is halogen;
R4 is an R1 member, thioalkyl, alkoxyalkyl or polyalkoxyalkyl, carbamyl, halogen, amino, nitro, cyano, hydroxy, C1-10 heterocycle containing O, S(O)m and/or NR18 hetero atoms, C6-12 aryl, aralkyl or alkaryl, YR13, CR14, YR15 or NR16R17 group and any two R4 groups combined through a saturated and/or unsaturated carbon, -(C=X)-, and/or hetero O, S(O)m and/or NR18 linkage to form a cyclic ring having up to 9 ring members which may be substituted with any of said R4 members;
X is O, S(O)m, NR19 or CR20R21;
Y is O, S(O)m or NR22;
R8-22 are hydrogen or one of the R4 members;
m is 0-2 and
n is 1 to 5.
2. Compounds according to Formula II
and agriculturally-acceptable salts and hydrates thereof wherein
R1 is C1-5 alkyl, alkylthio, alkoxyalkyl, C2-4 alkenyl, benzyl, which members may optionally be substituted with halogen, amino, nitro, cyano, hydroxy groups or - - YR8;
R2, R3, X, Y and R8 are as defined for Formula I; R5 is halogen or hydrogen;
R6 and R7 are as defined for the R4 member of Formula I.
3. Compounds according to Formula III:
and agriculturally-acceptable salts and hydrates thereof wherein
R1 is C1-5 alkyl;
R2, R3 and R5 are as previously defined; R6 is halogen, nitro, cyano, YR10 and
R7 is hydrogen or an R4 member or R6 and R7 are combined through a saturated and/or unsaturated carbon, -(C=X)-, and/or hetero O, S(O)m and/or NR18 linkage to form a cyclic ring having up to 9 ring members which may be substituted with any of said R4 members, provided that when said linkage contains -NR18-, said cyclic ring has at least six ring members and
X, Y, R18 and m are as previously defined.
4. Compounds, salts and hydrates according to Claim 3 wherein
R1 is methyl;
R2 is CF3 , CF2Cl or CF2H ;
R3 is chloro or bromo ;
R5 is f luoro ;
R6 is chloro ;
R7 is propargyloxy , allyloxy , polyalkoxy ,
OCH (R23) COR24 where R23 is hydrogen , methyl or ethyl and R24 is YR10 or NR11R12 ;
R6 and R7 are combined through an
-OCH2 ( C=O) N (R18) -linkage to give a fused six-member ring and
Y , R10-R12 and R18 are as previously defined .
5. Compound according to Claim 4 selected from the group consisting of :
4-Chloro-3- (4-chloro-2-fluoro-5-progargyl- oxyphenyl)-1-methyl-5-(trifluoromethyl)-1H- pyrazole,
2-(2-Chloro-5-(4-chloro-1-methyl-5-(tri- fluoromethyl)-1H-pyrazol-3-yl)-4- fluorophenoxy)propanoic acid, ethyl ester,
(2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorophenoxy) acetic acid, 1-methylethyl ester, 4-Chloro-3-(4-chloro-2-fluoro-5-(methoxy- methoxy)phenyl)-1-methyl-5- (trifluoromethyl)-1H-pyrazole,
4-Chloro-3-(4-chloro-2-fluoro-5-(methoxy- ethoxy)phenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole,
(2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorophenoxy) acetic acid, 1,1-dimethylethyl ester, (2-Chloro-5-(4-chloro-1-methyl-5-
(trifluoromethyl)-1H-pyrazol-3-yl)-4- fluorophenoxy)-acetic acid,
2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 2-ethoxy-1-methyl-2-oxoethyl ester,
2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 2-methoxy-1-methyl-2-oxoethyl ester, 2-Chloro-5-(4-chloro-1-methyl-5-(trifluoro- methyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, ethyl ester,
2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 1-methylethyl ester and
6-(4-Chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-7-fluoro-4-(2-propynyl)-2H- 1,4-benzoxazin-3-(4H)-one.
6. 4-Chloro-3-(4-chloro-2-fluoro-5- propargyloxyphenyl)-1-methyl-5-(trifluoromethyl)-1H- pyrazole.
7. (2-Chloro-5-(4-chloro-1-methyl-5- (trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorophenoxy) acetic acid, 1-methylethyl ester.
8. 2-Chloro-5-(4-chloro-1-methyl-5-(tri- fluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 2- methoxy-1-methyl-2-oxoethyl ester.
9. 2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 1- methylethyl ester.
10. 6-(4-Chloro-1-methyl-5-(trifluoromethyl)- 1H-pyrazol-3-yl)-7-fluoro-4-(2-propynyl)-2H-1,4- benzoxazin-3-(4H)-one.
11. Herbicidal composition comprising an adjuvant and a herbicidally-effective amount of a compound according to Formula I:
and agriculturally-acceptable salts and hydrates thereof wherein
R1 is independently C1-8 alkyl; C3-8 cycloalkyl, cycloalkenyl, cycloalkylalkyl, or cycloalkenylalkyl; C2-8 alkenyl or alkynyl; benzyl; and said R1 members substituted with halogen, amino, nitro, cyano, hydroxy, alkoxy, alkylthio,
X
- YR8, - R9, YR10, or NR11R12;
R2 is C1-5 haloalkyl;
R3 is halogen;
R4 is an R1 member, thioalkyl, alkoxyalkyl or polyallcoxyalkyl, carbamyl, halogen, amino, nitro, cyano, hydroxy, C1-10 heterocycle containing O, S(O)m and/or NR18 hetero atoms, C6-12 aryl, aralkyl or alkaryl,
X CYR13, - CR14, YR15 or NR16R17 group and any two R4 groups combined through a saturated and/or unsaturated carbon, -(C=X)-, and/or hetero O, S (O)m and/or NR18 linkage to form a cyclic ring having up to 9 ring members which may be substituted with any of said R4 members; X is O, S(O)m, NR19 or CR20R21;
Y is O, S(O)m or NR22;
R8-22 are hydrogen or one of said R4 members;
m is 0-2 and
n is 1 to 5.
12. Herbicidal composition comprising an adjuvant and a herbicidally-effective amount of a compound according to Formula II:
and agriculturally-acceptable salts and hydrates thereof wherein
R1 is C1-5 alkyl, alkylthio, alkoxyalkyl, C2-4 alkenyl, benzyl, which members may optionally be substituted with halogen, amino, nitro, cyano, hydroxy groups or - - YR8;
R2, R3, X, Y and R8 are as defined for Formula I; R5 is halogen or hydrogen;
R6 and R7 are as defined for the R4 member of Formula I.
13. Composition according to Claim 12 where in Formula II the substituted-phenyl member is in the 3- position of the substituted pyrazole member resulting in compounds according to Formula III: and agriculturally-acceptable salts and hydrates thereof wherein
R1 is C1-5 alkyl;
R2, R3 and R5 are as previously defined; R6 is halogen, nitro, cyano, YR10 and
R7 is hydrogen or an R4 member or
R6 and R7 are combined through a saturated and/or unsaturated carbon, -(C=X)-, and/or hetero O, S(O)m and/or NR18 linkage to form a cyclic ring having up to 9 ring members which may be substituted with any of said R4 members and
X, Y, R18 and m are as previously defined.
14. Composition according to Claim 13 where in Formula III
R1 is methyl;
R2 is CF3, CF2Cl or CF2H;
R3 is chloro or bromo;
R5 is fluoro;
R6 is chloro;
R7 is propargyloxy, allyloxy, polyalkoxy, OCH(R23)COR24, wherein R23 is hydrogen, methyl or ethyl and R24 is YR10 or NR11R12;
R6 and R7 may be combined through an
-OCH2(C=O)N-(R18)-linkage to give a fused six-member ring and
Y, R10-R12 and R18 are as previously defined.
15. Composition according to Claim 14 wherein said compound is selected from the group consisting of
4-Chloro-3-(4-chloro-2-fluoro-5-progargyl- oxyphenyl)-1-methyl-5-(trifluoromethyl)-1H- pyrazole,
2-(2-Chloro-5-(4-chloro-1-methyl-5-(tri- fluoromethyl)-1H-pyrazol-3-yl)-4- fluorophenoxy)propanoic acid, ethyl ester, (2-Chloro-5-(4-chloro-1-raethyl-5-(trifluoro- methyl)-1H-pyrazol-3-yl)-4-fluorophenoxy)acetic acid, 1-methylethyl ester, 4-Chloro-3-(4-chloro-2-fluoro-5-(methoxy- methoxy)phenyl)-1-methyl-5- (trifluoromethyl)-1H-pyrazole,
4-Chloro-3-(4-chloro-2-fluoro-5-(methoxy- ethoxy)phenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole,
(2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluoro- phenoxy) acetic acid, 1,1-dimethylethyl ester,
(2-Chloro-5-(4-chloro-1-methyl-5-
(trifluoromethyl)-1H-pyrazol-3-yl)-4- fluorophenoxy)-acetic acid,
2-Chloro-5-(4-chloro-1-methyl-5-(trifluoro- methyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 2-ethoxy-1-methyl-2-oxoethyl ester, 2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 2-methoxy-1-methyl-2-oxoethyl ester, 2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, ethyl ester,
2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 1-methylethyl ester and
6-(4-Chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-7-fluoro-4-(2-propynyl)-2H- 1,4-benzoxazin-3-(4H)-one.
16. Composition comprising an inert adjuvant and a herbicidally-effective amount of 4-Chloro-3-(4- chloro-2-fluoro-5-propargyloxyphenyl)-1-methyl-5- (trifluoromethyl)-1H-pyrazole.
17. Composition comprising an inert adjuvant and a herbicidally-effective amount of (2-Chloro-5-(4- chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4- fluoro-phenoxy) acetic acid, 1-methylethyl ester.
18. Composition comprising an inert adjuvant and a herbicidally-effective amount of 2-Chloro-5-(4- chloro-1-methy1-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4- fluorobenzoic acid, 2-methoxy-1-methyl-2-oxoethyl ester.
19. Composition comprising an inert adjuvant and a herbicidally-effective amount of 2-Chloro-5-(4- chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4- fluorobenzoic acid, 1-methylethyl ester.
20. Composition comprising an inert adjuvant and a herbicidally-effective amount of 6-(4-Chloro-1-methyl- 5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-fluoro-4-(2- propynyl)-2H-1,4-benzoxazin-3-(4H)-one.
21. Method for combatting undesirable plants in crops which comprises applying to the locus thereof a herbicidally-effective amount of a compound according to Formula I
and agriculturally-acceptable salts and hydrates thereof wherein
R1 is independently C1-8 alkyl; C3-8 cycloalkyl, cycloalkenyl, cycloalkylalkyl, or cycloalkenylalkyl; C2-8 alkenyl or alkynyl; benzyl; and said R1 members substituted with halogen, amino, nitro, cyano, hydroxy, alkoxy, alkylthio. X
-CYR8 , R9, YR10 , or NR11R12 ;
R2 is C1-5 haloalkyl;
R3 is halogen;
R4 is an R1 member, thioalkyl, alkoxyalkyl or polyalkoxyalkyl, carbamyl, halogen, amino, nitro, cyano, hydroxy, C1-10 heterocycle containing O, S(O)m and/or NR18 hetero atoms, C6-12 aryl, aralkyl or alkaryl, YR13, R14, YR15 or NR16R17 group and any two R4 groups combined through a saturated and/or unsaturated carbon, -(C=X)-, and/or hetero O, S(O)m and/or NR18 linkage to form a cyclic ring having up to 9 ring members which may be substituted with any of said R4 members;
X is O, S(O)m, NR19 or CR20R21;
Y is O, S(O)m or NR22;
R8-22 are hydrogen or one of said R4 members;
m is 0-2 and
n is 1-5.
22. Method according to Claim 21 where in the substituted phenyl and the resulting compounds are those according to Formula II
and agriculturally-acceptable salts and hydrates thereof wherein
R1 is C1-5 alkyl, alkylthio, alkoxyalkyl,
C2-4 alkenyl, benzyl, which members may optionally be substituted with halogen, amino, nitro, cyano, hydroxy groups or - - YR8 ;
R2, R3, X, Y and R8 are as defined for Formula I; R5 is halogen or hydrogen;
R6 and R7 are as defined for the R4 member of Formula I.
23. Method according to Claim 22 where in
Formula II the substituted-phenyl member is in the 3- position of the substituted-pyrazole member resulting in compounds according to Formula III:
and agriculturally-acceptable salts and hydrates thereof wherein
R1 is C1-5 alkyl ;
R2, R3 and R5 are as previously defined; R6 is halogen, nitro, cyano, YR10 and
R7 is hydrogen or an R4 member or
R6 and R7 are combined through a saturated and/or unsaturated carbon, -(C=X)-, and/or hetero O, S(O)m and/or NR18 linkage to form a cyclic ring having up to 9 ring members which may be substituted with any of said R4 members, provided that when said linkage contains
O -C-NR18-, said cyclic ring has at least six ring members and
X, Y, R18 and m are as previously defined.
24. Method according to Claim 23 where in Formula III
R1 is methyl;
R2 is CF3, CF2Cl or CF2H;
R3 is chloro or bromo;
R5 is fluoro;
R6 is chloro;
R7 is propargyloxy, allyloxy, polyalkoxy,
OCH(R23)COR24 where R23 is hydrogen, methyl or ethyl and R24 is YR10 or NR11R12;
R6 and R7 are combined through an
-OCH2(C=O)N(R18)-linkage to give a fused six-member ring and
Y, R10-Rl2 and R18 are as previously defined.
25. Method according to Claim 24 wherein said compound is selected from the group consisting of
4-Chloro-3-(4-chloro-2-fluoro-5-progargyl- oxyphenyl)-1-methyl-5-(trifluoromethyl)-1H- pyrazole,
2-(2-Chloro-5-(4-chloro-1-methyl-5-(tri- fluoromethyl)-1H-pyrazol-3-yl)-4- fluorophenoxy)-propanoic acid, ethyl ester, (2-Chloro-5-(4-chloro-1-methyl-5-(trifluoro- methyl)-1H-pyrazol-3-yl)-4-fluorophenoxy) acetic acid, 1-methylethyl ester, 4-Chloro-3-(4-chloro-2-fluoro-5-(methoxy- methoxy)phenyl)-1-methyl-5- (trifluoromethyl)-1H-pyrazole,
4-Chloro-3-(4-chloro-2-fluoro-5-(methoxy- ethoxy)phenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole,
(2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluoro- phenoxy)acetic acid, 1,1-dimethylethyl ester,
(2-Chloro-5-(4-chloro-1-methyl-5-
(trifluoromethyl)-1H-pyrazol-3-yl)-4- fluorophenoxy)-acetic acid, 2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 2-ethoxy-1-methyl-2-oxoethyl ester,
2-Chloro-5-(4-chloro-1-methyl-5-(trifluoro- methyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 2-methoxy-1-methyl-2-oxoethyl ester,
2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, ethyl ester,
2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 1-methylethyl ester and
6-(4-Chloro-1-methyl-5-(trifluoromethyl)-1H- pyrazol-3-yl)-7-fluoro-4-(2-propynyl)-2H- 1,4-benzoxazin-3-(4H)-one.
26. Method according to Claim 24 wherein said compound according to Formula III is selected from the group consisting of
4-Chloro-3-(4-chloro-2-fluoro-5- propargyloxyphenyl)-1-methyl-5- (trifluoromethyl)-1H-pyrazole,
(2-Chloro-5-(4-chloro-1-methyl-5-
(trifluoromethyl)-1H-pyrazol-3-yl)-4- fluorophenoxy) acetic acid, 1-methylethyl ester.
2-Chloro-5-(4-chloro-1-methyl-5-(tri- fluoromethyl)-1H-pyrazol-3-yl)-4- fluorobenzoic acid, 2-methoxy-1-methyl-2- oxoethyl ester,
2-Chloro-5-(4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluorobenzoic acid, 1-methylethyl ester and
6-(4-Chloro-1-methy1-5-(trifluoromethyl)-1H- pyrazol-3-yl)-7-fluoro-4-(2-propynyl)-2H-
1,4-benzoxazin-3-(4H)-one.
27. Method according to Claim 24 wherein said crops are soybeans, cotton, corn, wheat or barley.
28. Process for preparing compounds of Formula
B
which comprises reacting a compound of Formula A
with a substituted or unsubstituted hydrazine; provided that when the hydrazine is unsubstituted, the resulting compound of Formula C is
reacted with an alkylating agent and wherein in the above formulae, R1, R2, R4 and n are as previously defined.
29. Process according to Claim 28 wherein the major regioisomer compound of Formula B is a 1-alkyl-3- aryl-5-haloalkylpyrazole compound.
30. Process according to Claim 29 wherein the alkylating reaction is conducted in the absence of a base.
31. Process according to Claim 30 wherein
R1 is methyl;
R2 is CF3, CF2Cl or CF2H and
R4 is as previously defined.
32. Process according to Claim 31 wherein (R4)n is independently halogen, nitro, YR15 and C1-5 alkyl, wherein R15 is as previously defined and n is an integer from 1-3.
33. Process for preparing compounds according to Formula I which comprises reacting compounds
according to Formula B with a halogenating agent, wherein R1-R4 and n are as previously defined.
34. Process according to Claim 33 wherein said compounds according to Formula I are compounds according to Formula III, wherein R1-R7 are as previously defined; provided that R6 can also be hydrogen.
35. Process according to Claim 34 wherein
R1 is methyl;
R2 is CF3, CF2Cl or CF2H;
R3 is chloro or bromo;
R5 is fluoro and
R6 and R7 are as previously defined.
36. Process for the preparation of compounds of Formula III wherein R1, R2, R3 and R5 are as previously defined, which comprises reacting the corresponding precursor compound of Formula III wherein R6 or R7 is - YH or -NR16R17, wherein Y, R16 and R17 are as previously defined, with an alkylating or acylating agent.
37. Process according to Claim 36 wherein the reaction is an alkylation.
38. Process according to Claim 37 wherein in said compound of Formula III R7 is -YR15 wherein R15 is alkyl, alkenyl, alkynyl, alkoxy or polyalkoxy having up to 10 carbon atoms or R7 is -YCH2-p(R25)pCOYR27, wherein p is 0-2, Y is as defined for Formula I and R25 and R27 are an R4 member as defined for Formula I.
39. Process according to Claim 38 wherein in said precursor of Formula III, R7 is OH and in Formula III, R7 is propargyloxy, OCH(CH3)CO2C2H5, OCH2CO2CH(CH3)2 or OCH2CO2H.
40. Process for the preparation of compounds of Formula III represented by compounds according to
Formula N
which comprises alkylating a compound of Formula M
wherein R1-R3, R5, R28, R30 and q are as previously
defined.
41. Process according to Claim 40 wherein R30 is an alkyl, alkenyl or alkynyl radical having up to 5 carbon atoms or said radicals substituted with -YR13, wherein X, Y and R13 are as previously defined.
42. Process according to Claim 41 wherein R30 is propargyl.
43. Process for the preparation of compounds of Formula III represented by compounds according to
Formula Z.
which comprises the derivatization of compounds
according to Formula Y,
wherein R1-R3, R5, R6 and R38 are as previously defined.
44. Process according to Claim 43 wherein in Formula Z, R38 is OC1-5 alkyl, optionally substituted with X -YR3, wherein X, Y and R13 are as previously defined.
45. Process according to Claim 44 wherein R38 is
OCH(CH3)2 or OCH(CH3)CO2CH3.
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