AU6477890A - Glycosyl-etoposide prodrugs, a process for the preparation thereof and the use thereof incombination with functionalized tumor-specific enzyme conjugates - Google Patents
Glycosyl-etoposide prodrugs, a process for the preparation thereof and the use thereof incombination with functionalized tumor-specific enzyme conjugatesInfo
- Publication number
- AU6477890A AU6477890A AU64778/90A AU6477890A AU6477890A AU 6477890 A AU6477890 A AU 6477890A AU 64778/90 A AU64778/90 A AU 64778/90A AU 6477890 A AU6477890 A AU 6477890A AU 6477890 A AU6477890 A AU 6477890A
- Authority
- AU
- Australia
- Prior art keywords
- glycosyl
- specific enzyme
- preparation
- enzyme conjugates
- incombination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nanotechnology (AREA)
- Immunology (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The present invention relates to glycosyl-etoposide prodrugs, process for their preparation and their use in combination with functionalised tumour-specific enzyme conjugates for the treatment of cancers, and it specifically relates to 4'-O-glycosyl-etoposides as prodrugs which can be cleaved to cytotoxic agents on exposure to tumour-specific enzyme conjugates, where the liberated agent is suitable, by reason of its cytostatic activity, for the treatment of cancers.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3935016A DE3935016A1 (en) | 1989-10-20 | 1989-10-20 | GLYCOSYL ETOPOSIDE PRODRUGS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN COMBINATION WITH FUNCTIONALIZED TUMOR-SPECIFIC ENZYME CONJUGATES |
DE3935016 | 1989-10-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU6477890A true AU6477890A (en) | 1991-04-26 |
AU638064B2 AU638064B2 (en) | 1993-06-17 |
Family
ID=6391872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU64778/90A Ceased AU638064B2 (en) | 1989-10-20 | 1990-10-19 | Glycosyl-etoposide prodrugs, a process for the preparation thereof and the use thereof incombination with functionalized tumor-specific enzyme conjugates |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0423747B1 (en) |
JP (1) | JP3293086B2 (en) |
KR (1) | KR910007948A (en) |
AT (1) | ATE168695T1 (en) |
AU (1) | AU638064B2 (en) |
CA (1) | CA2028086A1 (en) |
DE (2) | DE3935016A1 (en) |
DK (1) | DK0423747T3 (en) |
ES (1) | ES2119738T3 (en) |
GR (1) | GR3027569T3 (en) |
IE (1) | IE903764A1 (en) |
PT (1) | PT95620B (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5851527A (en) * | 1988-04-18 | 1998-12-22 | Immunomedics, Inc. | Method for antibody targeting of therapeutic agents |
US7241595B2 (en) * | 1989-10-20 | 2007-07-10 | Sanofi-Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
DE68928946T2 (en) * | 1989-12-11 | 1999-10-21 | Immunomedics Inc | METHOD FOR DETECTING DIAGNOSTIC OR THERAPEUTIC AGENTS BY ANTIBODIES |
FR2676058B1 (en) * | 1991-04-30 | 1994-02-25 | Hoechst Lab | GLYCOSYLATED PRODUCTS, THEIR PREPARATION PROCESS AND THEIR USE IN THE TREATMENT OF CANCERS. |
IT1250692B (en) * | 1991-07-23 | 1995-04-21 | PROCEDURE FOR THE PREPARATION OF DEMETYLEPIPODOPHYLOTOXY-BETA-D-GLUCOSIDES. | |
DE4236237A1 (en) * | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, their preparation and use as medicines |
DE19702988A1 (en) * | 1997-01-28 | 1998-07-30 | Hoechst Ag | Isoxazole and crotonic acid amide derivatives and their use as pharmaceuticals and diagnostics |
US6713454B1 (en) | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
WO2001049693A1 (en) * | 2000-01-03 | 2001-07-12 | Korea Research Institute Of Chemical Technology | 4-O-[2-(N,N-DIALKYLAMINO)-2-DEOXY-4,6-O,O-beta-D-GLUCOSYL]-4'-O-DEMETHYL-EPI-PODOPHYLLOTOXIN, DERIVATIVES, AND AN ANTICANCER COMPOSITION CONTAINING SAME |
WO2003035661A1 (en) * | 2001-10-26 | 2003-05-01 | Centre National De La Recherche Scientifique | Derivatives of etoposide and analogs, and pharmaceutical compositions containing them |
ATE483714T1 (en) | 2001-12-03 | 2010-10-15 | Universitaetsklinikum Charite | PODOPHYLLOTOXINS AS ANTIPROLIFERATIVE AGENTS |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3329184A1 (en) * | 1983-08-12 | 1985-02-21 | Behringwerke Ag, 3550 Marburg | MONOCLONAL ANTIBODIES WITH SPECIFICITY FOR MEMBRANE-ASSOCIATED ANTIGENS |
GB8705477D0 (en) * | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
NZ225599A (en) * | 1987-08-04 | 1991-09-25 | Bristol Myers Co | Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells |
DE4002888A1 (en) * | 1990-02-01 | 1991-08-08 | Behringwerke Ag | ANTHRACYCLIN-GLYCOSYL PRODRUGS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN COMBINATION WITH FUNCTIONALIZED TUMOR-SPECIFIC ENZYME CONJUGATES |
-
1989
- 1989-10-20 DE DE3935016A patent/DE3935016A1/en not_active Withdrawn
-
1990
- 1990-10-17 DE DE59010838T patent/DE59010838D1/en not_active Expired - Lifetime
- 1990-10-17 AT AT90119886T patent/ATE168695T1/en not_active IP Right Cessation
- 1990-10-17 DK DK90119886T patent/DK0423747T3/en active
- 1990-10-17 EP EP90119886A patent/EP0423747B1/en not_active Expired - Lifetime
- 1990-10-17 ES ES90119886T patent/ES2119738T3/en not_active Expired - Lifetime
- 1990-10-18 PT PT95620A patent/PT95620B/en not_active IP Right Cessation
- 1990-10-19 AU AU64778/90A patent/AU638064B2/en not_active Ceased
- 1990-10-19 CA CA002028086A patent/CA2028086A1/en not_active Abandoned
- 1990-10-19 JP JP27953590A patent/JP3293086B2/en not_active Expired - Lifetime
- 1990-10-19 IE IE376490A patent/IE903764A1/en not_active IP Right Cessation
- 1990-10-20 KR KR1019900016761A patent/KR910007948A/en not_active Application Discontinuation
-
1998
- 1998-08-04 GR GR980401753T patent/GR3027569T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
ES2119738T3 (en) | 1998-10-16 |
IE903764A1 (en) | 1991-04-24 |
PT95620A (en) | 1991-09-13 |
PT95620B (en) | 1997-08-29 |
DE59010838D1 (en) | 1998-08-27 |
JP3293086B2 (en) | 2002-06-17 |
AU638064B2 (en) | 1993-06-17 |
JPH03135993A (en) | 1991-06-10 |
ATE168695T1 (en) | 1998-08-15 |
EP0423747B1 (en) | 1998-07-22 |
GR3027569T3 (en) | 1998-11-30 |
KR910007948A (en) | 1991-05-30 |
DE3935016A1 (en) | 1991-04-25 |
EP0423747A3 (en) | 1991-09-11 |
DK0423747T3 (en) | 1999-04-26 |
EP0423747A2 (en) | 1991-04-24 |
CA2028086A1 (en) | 1991-04-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |