AU629664B2 - Prosthesis for preventing the gastric reflux in the oesophagus - Google Patents

Prosthesis for preventing the gastric reflux in the oesophagus Download PDF

Info

Publication number
AU629664B2
AU629664B2 AU59364/90A AU5936490A AU629664B2 AU 629664 B2 AU629664 B2 AU 629664B2 AU 59364/90 A AU59364/90 A AU 59364/90A AU 5936490 A AU5936490 A AU 5936490A AU 629664 B2 AU629664 B2 AU 629664B2
Authority
AU
Australia
Prior art keywords
prosthesis
eosophagus
lips
wall
valve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU59364/90A
Other versions
AU5936490A (en
Inventor
Norman Godin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of AU5936490A publication Critical patent/AU5936490A/en
Application granted granted Critical
Publication of AU629664B2 publication Critical patent/AU629664B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/044Oesophagi or esophagi or gullets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The prosthesis is configured like an anti-return valve arranged preferably in the area where the oesophagus and the hiatal hernia meet. Said valve is comprised of a tubular part (7) associated with an annular fixing element (8). The tubular part flatens progressively to form two joined lips (9, 10). It is possible to form said valve with a wall thickness which increases from the free end of the lips (9 and 10) towards the annular fixing part (8) in order to avoid an easy returning under the effect of the surging pressure. During the passage of the alimentary bolus, the lips (9, 10) are spaced apart and joined again owing to their natural elasticity. A metal wire (16) embedded in the annular fixing part (8) is used for the radiologic marking.

Description

5052F/SC OPI DATE 22/02/91 Pcr AOJP DATE 28/03/91 APPLN. I D 59364 PCT NUMBER PCI/CH90/0011 DEMANDE INTERNATIt,_ I I. &JI %laLi z..z'j-iiIL yrii 1 .,1ETS (51) Classification Internationale des brevets 5 (11) Numnero de publication Internationale: WO, 91/01117 A61F 2/02 Al (43) Date de publication intemnationale: 7 f~vrier 1991 (07.02.91) (21) Numnkro de la deniande internationale: PCT/CH9O/0017 1 Publice Avec rapport de recherche internationale.
(22) Date de dipfit international: 16 juillet 1990 (16.07.90) Avant I'expiration du ddai pr~vu pour la modijfication des revendications, sera repub~ie si de telles modijfi cations sont repues.
Donnies relatives a la priorite: 2703/89-2 20juillet 1989 (20.07.89) CH (71)(72) Diposant et inventeur: GODIN, Norman [CH/CH]; 4, quai du Seujet, CH-1201 Gen~ve (CH).
(74) Mandataires: DOUSSE, Blasco etc. 7, route de Drize,6 26 CH-1227 Carouge (CH).
(81) Etats d~signis: AT (brevet europ~en), AU, BE (brevet europ~en), CA, CH (brevet europ, en), DE (brevet euro- DK (brevet europ~en), ES (brevet europ~en), FR (brevet europ~en), GB (brevet europ~en), IT (brevet europ~en), JP, LU (brevet europ~en), NL (brevet europ~en), SE (brevet europ~en), US.
(54) Title: PROSTHESIS FOR PREVENTING THE GASTRIC REFLUX IN THE OESOPHAGUS (54)Titre: PROTHESE POUR EMPECHER LES REFLUX GASTRIQUES DANS L'cESOPHAGE (57) Abstract The prosthesis is configured like an anti-return valve arranged preferably in the area where the oesophagus and the hiatal hernia meet. Said valve is comprised of a tubular part associated with an annular fixing element The tubular part flat-4 ens progressively to formn two joined lips 10). It is possible to form said valve with a wall thickness which increases from the free end of the lips (9 and 10) towards the annular fixing part in order to avoid an easy returning under the effect of the surging pressure. During the passage of the alimentary bolus, the lips 10) are spaced apart and joined again owing to their natural elasticity. A metal wire (16) em- bedded in the annular fixing part is used for the radiologic marking.
(57) Abrege6 Cette proth~se a la formne d'une valve anti-retour dispos~e de preference dans la zone o11 l'sophage et l'hernie hiatale se rejoignent. Cette valve comporte une partie tubulaire associ~e A un 16ment annulaire de fixation La partie tubulaire s'aplatit ensuite progressivement pour former deux 16vres jointives 10). 11 est possible de former cette valve avec une 6paisseur de paroi qui augmente de l'extr~mit6 Ii- bre des 16vres (9 et 10) en direction de la partie annulaire de fixation pour &viter le retournement trop facile sous l'effet de la pression de reflux. Lors du passage du bol1 alimentaire, les 16vres 10) s'6cartent puis se rejoignent grAce i leur 61asticit6 naturelle. Un fil m~tallique (16) noy dans la partie annulaire de la fixation sert au rep~rage radiologique.
Voir au verso PROSTHESIS FOR PREVENTING THE GASTROC REFLUX IN THE OESOPHAGUS The present invention relates to a prosthesis for preventing gastric reflux in the esophagus, including a valve associated with an annular fixation portion and having an opening that is elastically kept closed.
Esophagitis is caused by chronic gastric reflux. Although the mucus of the stomach is capable of withstanding the highly acid pH of the gastric secretions, which is close to 1, this is Snot the case for the mucus of the esophagus. Consequently, when this reflux is chronic, it attacks the mucus of the esophagus and creates ulcers, which over the long term can cause shrinkage of the esophageal conduit.
This gastric reflux is generally associated with a hiatal hernia. The most currently used therapy for this type of affliction makes use of medicines. There are three categories: antacids, which tend to make the environment neutral by the intake of an alkaline product, H 2 antihistamines, which fix on the H 2 receptor of the parietal cell. Recently, a new medicine has been proposed that in turn blocks the production of H ions by the parietal cell. However, this medicine has no further effect as soon as it ceases to be administered, and it cannot be taken S continuously, because it might cause tumors, which has been confirmed at least for the rat. Finally, the thi.rd class comprises medicines that increase the motility of the esophagus and the stomach and tend to reduce the length of contact of the acid reflux with the esophagus. This.therapy does not attack the primary cause of the ailment, which is gastric reflux, which reappears as soon as the treatment with medicine stops, so that the patient is forced to take medication permanently. This solution is clearly unsatisfactory both medically and economically.
As an alternative to this medication route, it has already been proposed to use an external prosthesis for mechanical opposition to gastric reflux. This external prosthesis is formed by an elastically extensible ring disposed around the end where the esophagus discharges into the stomach. By thus surrounding the base of the esophagus, the centripetal force that this ring exerts offers a flow resistance that tends to prevent gastric reflux from rising in the esophagus. Nevertheless, the effect of this ring is equally manifest with gastric reflux and with deglutition of the gastric contents. Consequently, the centripetal pressure cannot be selected to be too high, or else it may cause an unacceptable impairment to swallowing. The absence of selectivity in this solution in terms of the direction of flow does not make it possible to guarantee total efficacy of this external prosthesis. It has also been found that the external prosthesis can be pushed upward by the pressure of gastric reflux, so that the base of the esophagus is again exposed to attack by the acidity of the gastric juices. This ring is located outside the esophagus, and so its position cannot be further modified by endoscopy. Shifts of this external prosthesis in the abdominal cavity limit its use and can have risks.
These disadvantages explain why the use of this prosthesis is not widespread, because it does not offer a sufficient guarantee. If it fails, then recourse to medication must be made anew, and the proportion of failures has proved to be high.
Finally, there are also surgical procedures, in particular the Nissen-Rossetti fundoplicature, which comprisns making a sleeve with the gastric fundus surrounding theAh4rt, under the diaphragm. The disadvantage of such an operation is that in the case of deficient esophageal peristalsis it may cause severe dysphagia. Still other surgical procedures exist. Nevertheless, all the surgical solutions have postoperative risks, such as a -2i: I ~le 0688k/lfg 3 recurrence of reflux after relaxation of the sutures, dysphagia when the sleeve is too tight, and sliding of part of the stomach upstream of the sleeve, thus causing severe reflux eosophagitis. This patient thus operated upon can also neither burp nor vomit, which is difficult for some patients to tolerate.
A prosthesis of an eleastomer material has also already been proposed in US Patent 4,846,836, and is intended to be placed in the eosophagus and includes a cone inside a tubular portion intended for fixation of the prosthesis.
The cone has a slit apex and is aimed toward the stomach, comprising a sort of funnel that ends in a valve, the slit of which is intended to open by a peristaltic thrust exerted on the alimentary bolus, but to prevent flow in the opposite direction. A second slit, made between the base of the cone and the tubular portion, is intended to open under a certain reflux pressure to enable vomiting.
A major disadvantage of this prosthesis is due to the fact that the gastric juices must pass through a substantially reduced cross section of the valve at the apex of the cone; this cone is necessary to enable flow in o reverse to have access to the second opening intended for S reflux in the case of vomiting. It is clear that such a valve comprises a certain hindrance to the patient, who will have difficulty in swallowing, particularly solids, because of the shrinkage at the passage through the slit, which can cause pain that is difficult to tolerate.
:o "The object of the present invention is at least in part to overcome the disadvantages of the above arrangements.
To this end, the subject of this invention is a prosthesis for preventing gastric reflux in the eosophagus S comprising: a fixing portion having a circular cross section substantially corresponding to the cross-section of the eosophagus, for fixing the prosthesis to the wall of the eosophagus; and a valve means to control the flow of material in the eosophagus comprising a resilient tubular shaped wall,
'V.
0688k/lfg 3a said valve means depending at one end from the fixing portion, the tubular wall progressively collapsing toward the opposite end to substantially resiliently close the flow cross-section of the valve means; said opposite end being intended to be placed in the eosophagus downstream of the fixing portion so that, in use, any force generated on an alimentary bolus by the peristaltic wave of the eosophagus tends to space the resiliently collapsed wall apart, while any force in the opposite direction tends to prevent gastric reflux through the collapsed end wall as long as it does not exceed a limit substantially greater than that generated by the peristaltic wave of the of the eosophagus and thus causing an at least partial inversion of said tubular shaped valve means.
The essential advantage of the proposed arrangement is due to the fact that the same valve, while it has a unidirectional effect, enables reflux when the pressure is sufficient., that is, iC S. S t ti
I
it 1 t in the case of vomiting. This valve also has the enormous advantage that in the open position it offers a passage cross section that is substantially equal to that of the esophagus, thus permitting easy swallowing of food.
The accompanying drawing schematically and by way of example illustrates an embodiment and two variants of the prosthesis that is the subject of the present invention.
Fig. 1 is a perspective view in section of one embodiment of this prosthesis, affixed to the base of the esophagus.
Fig. 2 is an elevational view of the embodiment of Fig. 1.
Fig. 3 is a sectional view along the line III-III of Fig.
2.
Fig. 4 is an elevational view of a variant of Figs. 1-3.
Fig. 5 is a sectional view along the line V-V of Fig. 4.
Fig. 6 is a sectional view along the line VI-VI of Fig. Fig. 7 is a view similar to Fig. 4, of a variant.
Fig. 8 is a sectional view along the line VIII-VIII of Fig.
7.
Fig. 9 is a view along the line IX-IX of Fig. 7.
Fig. 10 is a perspective view of the variant of Figs. 7-9, disposed in a hiatal hernia.
Fig. 1 shows the top of the stomach 1, which has a hiatal hernia 3 of the diaphragm 2. Although gastric reflux is not always linked with the presence of such a hernia, nevertheless it is the most frequent cause of this affliction. The base of the esophagus 4 opens into this hiatal hernia 3.
The embodiment shown in Figs. 1-3 has a valve formed of a tubular portion 7 associated with an annular fixation element 8.
This tubular portion, which moreover may itself form the fixation element, then flattens progressively to form two joined lips 9 and This solution offers very slight resistance to the passage of the gastric juices and requires little or no capacity for -4- L 1 extension, in so far as it suffices that the lips 9 and 10 are spaced apart from one another to allow passage to the flow. This prosthesis can be made from a silicone-based elastomer with two components of medical quality, sold under the mark Silastsicby Dow Corning Corporation, or it may be made of a biocompatible polymer such as that described in US Patent 4,657,544 or in US Patent 4,759,757, which can be suitable for such an application.
This is a solvent-free graft polymer with two hydrophilic or hydrophobic components, into which an inorganic water-soluble salt that has been ground and sifted is incorporated. A tube is then formed, and the salt crystals are washed out of the tube thus formed to make a honeycombed structure that increases flexibility and makes it possible to improve the adhesive bonding properties, in the case where this mode of fixation is used. Aside from the aforementioned elastomers, fluoroelastomer compounds such as Viton% can be cited, along with rubbers of the butyl type. The valves can be formed with a wall thickness that increases from the free end of the lips 9 and 10 toward the annular fixation part 8, to avoid overly easy inversion under the influence of the reflux pressure. It can be noted that this embodiment affords a large surface area on which the reflux pressure can act to close the lips 9 and 10. If the tubular portion is slightly more rigid because of its increased thickness, the valve functions essentially by moving the lips 9 and 10 farther apart and closing them again.
As can also be observed in Figs. 1-3, a very fine metal wire 16 can be embedded in the annular fixation element, with a view to permitting radiologic marking of the position of the valve.
Other embodiments based on this same concept are conceivable. The variant shown in Figs. 4 and 5 is distinguished essentially by the fact that the flattening of the annular portion L 1 11 to form the lips 12 and 13 is much more sudden, thus reducing the axial dimension of the valve. This dimensional reduction has the advantage of occupying less space and making it possible to accommodate the prosthesis in its entirety in practically all hiatal hernias. In this example, the axial dimension of the prosthesis is on the order to 15 to 20 mm. However, the primary difference in this variant is the fact that in the position of repose, the two lips 12 and 13 remain separated as shown in Fig.
so as to facilitate the passage of the gastric juices and prevent food residues and saliva from remaining in the valve. By keeping the lips 12 and 13 apart, this risk is practically avoided, and saliva can flow into the stomach without the aid of any force for spacing the lips 12 and 13 apart. In this variant, the thickness of the wall of the level of the end of the lips 12 and 13 is on the order of 0.2 to 0.4 mm, while it thickens to attain a value of 1.2 to 1.7 mm in the annular portion 11.
In the case of gastric acid reflux, the pressure exerted on the outer faces of the flattened portions that form the lips 12 and 13 cause the closure of these lips. Even if a small quantity of gastric acid passes between the lips, this reflux does not threaten to exceed the level of the valve and hence to attack the esophogeal mucus. As soon as the reflux pressure disappears, the lips 12 and 13 move apart again to the position of repose shown in Fig. 5 and allow the acid that may be located in the valve to drop downward again.
If the reflux pressure increases substantially, which occurs only in the case of vomiting, the lips 12 and 13 invert and allow the flow to pass in the opposite direction. In the variant shown in Figs. 4 and 5, it has been found that in the case of inversion, these lips return to their initial position by their intrinsic elasticity.
-6- Ap sJ, The second variant shown in Figs. 7-10 differs from that of Figs. 4 and 5 in that the lips 14 and 15 are asymmetrical, forming a D-shaped opening between them instead of the elongated O formed by the opening between the symmetrical lips 12 and 13. The reason for the choice of this asymmetrical form of the opening made between the lips 14 and 15 is the fact that the stomach itself has an asymmetrical shape, as illustrated in Fig. 6, such that the reflux pressure that is exerted on the lips 14 and 15 is not vertical but rather lateral, and that the lip 14 is thus subjected to higher pressure than the lip 15. Providing the lip 15 with a convex shape thus further facilitates the passage of the gastric juices. Contrarily, the straight lip 14 offers less resistance to deformation, and since it is subjected to the greatest reflux pressure, which comes from the right, it is pressed against the lip 15 and closes the orifice of the passage in case of reflux, with the lip 15 remaining practically immobile.
I
l~inOT-7- L i

Claims (4)

1. A prosthesis for preventing gastric reflux in the eosophagus comprising: a fixing portion having a circular cross section substantially corresponding to the cross-section of the eosophagus, for fixing the prosthesis to the wall of the eosophagus; and a valve means to control the flow of material in the eosophagus comprising a resilient tubular shaped wall, said valve means depending at one end from the fixing portion, the tubular wall progressively collapsing toward the opposite end to substantially resiliently close the flow cross-section of the valve means; said opposite end being intended to be placed in the eosophagus downstream of the fixing portion so that, in use, Sooo any force generated on an alimentary bolus by the peristaltic wairve of the eosophagus tends to space the resiliently collapsed wall apart, while any force in the opposite direction tends to prevent gastric reflux through the collapsed end wall as long as it does not exceed a limit substantially greater than that 8° generated by the peristaltic wave of the of the eosophagus and thus causing an at least partial inversion of said tubular shaped valve means.
2. The prosthesis of claim 1 wherein the fixing means is an integral extension of the tubular member.
3. The prosthesis as defined by claim 1 or claim 2, characterized in that the opposite end of the wall q i 0688k/lfg 9 forms an opening of reduced cross section in the position of repose.
4. The prosthesis as defined by any one of claims 1 to 3, wherein the thickness of the wall thins progressively in the direction of said opposite end. The prosthesis, substantially as herein described with reference to the drawings. DATED this llth day of August, 1992. NORMAN GODIN By His Patent Attorneys DAVIES COLLISON CAVE i tac tcI a i t t ct cc SI Ett 4 a t a t t a t t t *t 1 I 1: t ac a ca "a1 1 S a- a *dtr) wi I.; rnr I -m "l-nnnnnr~--rrm~*rrrr~rul---~ ABSTRACT OF THE DISCLOSURE The prosthesis is configured like an anti-return valve arranged preferably in the area where the oesophagus and the hiatal hernia meet. Said valve is comprised of a tubular part associated with an annular fixing element. The tubular part flatens progressively to form two joined lips. It is possible to form said valve with a wall thickness which increases from the free end of the lips towards the annular fixing part in order to avoid an easy returning under the effect of the surging pressure. During the passage of the alimentary bolus, the lips are spaced apart and joined again owing to their natural elasticity. A metal wire embedded in the annular fixing part is used for the radiologic marking.
AU59364/90A 1989-07-20 1990-07-16 Prosthesis for preventing the gastric reflux in the oesophagus Ceased AU629664B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH2703/89A CH680263A5 (en) 1989-07-20 1989-07-20
CH2703/89 1989-07-20

Publications (2)

Publication Number Publication Date
AU5936490A AU5936490A (en) 1991-02-22
AU629664B2 true AU629664B2 (en) 1992-10-08

Family

ID=4239698

Family Applications (1)

Application Number Title Priority Date Filing Date
AU59364/90A Ceased AU629664B2 (en) 1989-07-20 1990-07-16 Prosthesis for preventing the gastric reflux in the oesophagus

Country Status (10)

Country Link
EP (1) EP0435983B1 (en)
JP (1) JPH04500769A (en)
AT (1) ATE96640T1 (en)
AU (1) AU629664B2 (en)
CA (1) CA2035903C (en)
CH (1) CH680263A5 (en)
DE (1) DE69004409T2 (en)
DK (1) DK0435983T3 (en)
ES (1) ES2047337T3 (en)
WO (1) WO1991001117A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8337566B2 (en) 2002-04-08 2012-12-25 Barosense, Inc. Method and apparatus for modifying the exit orifice of a satiation pouch
US8747421B2 (en) 2008-11-10 2014-06-10 Boston Scientific Scimed, Inc. Multi-fire stapling systems and methods for delivering arrays of staples
US8845753B2 (en) 2001-08-27 2014-09-30 Boston Scientific Scimed, Inc. Satiation devices and methods
US8864008B2 (en) 2008-03-18 2014-10-21 Boston Scientific Scimed, Inc. Endoscopic stapling devices and methods
US9248038B2 (en) 2003-10-10 2016-02-02 Boston Scientific Scimed, Inc. Methods for retaining a gastro-esophageal implant
US9314361B2 (en) 2006-09-15 2016-04-19 Boston Scientific Scimed, Inc. System and method for anchoring stomach implant
US9445791B2 (en) 2003-10-10 2016-09-20 Boston Scientific Scimed, Inc. Systems and methods related to gastro-esophageal implants
US11950778B2 (en) 2010-05-21 2024-04-09 Boston Scientific Scimed, Inc. Tissue-acquisition and fastening devices and methods

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5314473A (en) * 1989-07-20 1994-05-24 Godin Norman J Prosthesis for preventing gastric reflux into the esophagus
DE4316971A1 (en) * 1993-05-21 1994-11-24 Georg Dr Berg Valve device for insertion in a hollow organ, a vessel or the like
CH688174A5 (en) * 1995-03-28 1997-06-13 Norman Godin Prosthesis to oppose the gastric reflux into the esophagus.
GB9807232D0 (en) 1998-04-03 1998-06-03 Univ Cardiff Aerosol composition
US6264700B1 (en) 1998-08-27 2001-07-24 Endonetics, Inc. Prosthetic gastroesophageal valve
ES2212623T3 (en) 1998-08-31 2004-07-16 Wilson-Cook Medical Inc. ANTI-REFLUJO ESOFAGIC PROTESIS.
EP1108400A1 (en) * 1999-12-13 2001-06-20 Biomedix S.A. Removable fixation apparatus for a prosthesis in a body vessel
US6436030B2 (en) 2000-01-31 2002-08-20 Om P. Rehil Hiatal hernia repair patch and method for using the same
US6675809B2 (en) 2001-08-27 2004-01-13 Richard S. Stack Satiation devices and methods
US7097665B2 (en) 2003-01-16 2006-08-29 Synecor, Llc Positioning tools and methods for implanting medical devices
US6845776B2 (en) * 2001-08-27 2005-01-25 Richard S. Stack Satiation devices and methods
IL148616A (en) * 2002-03-11 2008-03-20 Oded Nahleili Polymeric stent useful for the treatment of the salivary gland ducts
US9060844B2 (en) 2002-11-01 2015-06-23 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US7837669B2 (en) 2002-11-01 2010-11-23 Valentx, Inc. Devices and methods for endolumenal gastrointestinal bypass
US8070743B2 (en) 2002-11-01 2011-12-06 Valentx, Inc. Devices and methods for attaching an endolumenal gastrointestinal implant
US20040143342A1 (en) 2003-01-16 2004-07-22 Stack Richard S. Satiation pouches and methods of use
EP1740132B1 (en) 2004-04-26 2014-12-31 Synecor, LLC Restrictive and/or obstructive implant for inducing weight loss
US9055942B2 (en) 2005-10-03 2015-06-16 Boston Scienctific Scimed, Inc. Endoscopic plication devices and methods
CA2634891C (en) 2005-12-23 2014-09-23 Vysera Biomedical Limited A medical device suitable for treating reflux from a stomach to an oesophagus
ES2527923T3 (en) 2006-09-02 2015-02-02 Barosense, Inc. Intestinal sleeves and associated deployment systems and methods
US8221505B2 (en) 2007-02-22 2012-07-17 Cook Medical Technologies Llc Prosthesis having a sleeve valve
US20090030284A1 (en) 2007-07-18 2009-01-29 David Cole Overtube introducer for use in endoscopic bariatric surgery
US20090024143A1 (en) 2007-07-18 2009-01-22 Crews Samuel T Endoscopic implant system and method
CN101815509A (en) 2007-08-03 2010-08-25 沙克利公司 Nutritional dosage unit
US9763989B2 (en) 2007-08-03 2017-09-19 Shaklee Corporation Nutritional supplement system
US20090171383A1 (en) 2007-12-31 2009-07-02 David Cole Gastric space occupier systems and methods of use
EP2331017B1 (en) * 2008-06-20 2014-06-11 Vysera Biomedical Limited Esophageal valve
US8961539B2 (en) 2009-05-04 2015-02-24 Boston Scientific Scimed, Inc. Endoscopic implant system and method
AU2010331820B2 (en) 2009-12-18 2015-03-05 Vysera Biomedical Limited A urological device
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US8992410B2 (en) 2010-11-03 2015-03-31 Vysera Biomedical Limited Urological device
AU2012357751B2 (en) 2011-12-19 2017-12-14 Coloplast A/S A luminal prosthesis and a gastrointestinal implant device
US8956318B2 (en) 2012-05-31 2015-02-17 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9681975B2 (en) 2012-05-31 2017-06-20 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9451960B2 (en) 2012-05-31 2016-09-27 Valentx, Inc. Devices and methods for gastrointestinal bypass
US9757264B2 (en) 2013-03-13 2017-09-12 Valentx, Inc. Devices and methods for gastrointestinal bypass
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
WO2020204616A1 (en) * 2019-04-04 2020-10-08 고려대학교 산학협력단 Anti-reflux valve for preventing gastroesophageal reflux disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4846836A (en) * 1988-10-03 1989-07-11 Reich Jonathan D Artificial lower gastrointestinal valve

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4265694A (en) * 1978-12-14 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making unitized three leaflet heart valve
US4434810A (en) * 1980-07-14 1984-03-06 Vernay Laboratories, Inc. Bi-directional pressure relief valve
DE3207690A1 (en) * 1982-03-01 1983-09-08 Karl-Egon Dr. med. 1000 Berlin Gaul Venous valve prosthesis/artificial venous valve
DE8513185U1 (en) * 1985-05-04 1985-07-04 Koss, Walter, 6222 Geisenheim Endotube

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4846836A (en) * 1988-10-03 1989-07-11 Reich Jonathan D Artificial lower gastrointestinal valve

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9138340B2 (en) 2001-08-27 2015-09-22 Boston Scientific Scimed, Inc. Gastro-esophageal implants
US8845753B2 (en) 2001-08-27 2014-09-30 Boston Scientific Scimed, Inc. Satiation devices and methods
US9358144B2 (en) 2001-08-27 2016-06-07 Boston Scientific Scimed, Inc. Gastrointestinal implants
US8992457B2 (en) 2001-08-27 2015-03-31 Boston Scientific Scimed, Inc. Gastrointestinal implants
US8337566B2 (en) 2002-04-08 2012-12-25 Barosense, Inc. Method and apparatus for modifying the exit orifice of a satiation pouch
US9445791B2 (en) 2003-10-10 2016-09-20 Boston Scientific Scimed, Inc. Systems and methods related to gastro-esophageal implants
US9248038B2 (en) 2003-10-10 2016-02-02 Boston Scientific Scimed, Inc. Methods for retaining a gastro-esophageal implant
US10285836B2 (en) 2003-10-10 2019-05-14 Boston Scientific Scimed, Inc. Systems and methods related to gastro-esophageal implants
US9314361B2 (en) 2006-09-15 2016-04-19 Boston Scientific Scimed, Inc. System and method for anchoring stomach implant
US8864008B2 (en) 2008-03-18 2014-10-21 Boston Scientific Scimed, Inc. Endoscopic stapling devices and methods
US8747421B2 (en) 2008-11-10 2014-06-10 Boston Scientific Scimed, Inc. Multi-fire stapling systems and methods for delivering arrays of staples
US11202627B2 (en) 2008-11-10 2021-12-21 Boston Scientific Scimed, Inc. Multi-fire stapling systems and methods for delivering arrays of staples
US11950778B2 (en) 2010-05-21 2024-04-09 Boston Scientific Scimed, Inc. Tissue-acquisition and fastening devices and methods

Also Published As

Publication number Publication date
CH680263A5 (en) 1992-07-31
WO1991001117A1 (en) 1991-02-07
CA2035903C (en) 1999-10-19
AU5936490A (en) 1991-02-22
ATE96640T1 (en) 1993-11-15
JPH04500769A (en) 1992-02-13
ES2047337T3 (en) 1994-02-16
EP0435983B1 (en) 1993-11-03
CA2035903A1 (en) 1991-01-21
DK0435983T3 (en) 1994-03-28
DE69004409T2 (en) 1994-05-11
DE69004409D1 (en) 1993-12-09
EP0435983A1 (en) 1991-07-10

Similar Documents

Publication Publication Date Title
AU629664B2 (en) Prosthesis for preventing the gastric reflux in the oesophagus
US5314473A (en) Prosthesis for preventing gastric reflux into the esophagus
US4846836A (en) Artificial lower gastrointestinal valve
US8517972B2 (en) Pyloric valve
US20070027549A1 (en) Gastrointestinal anti-reflux prosthesis apparatus and method
EP1302177B1 (en) Anti-gastroesophageal reflux valvular prosthesis
CN1146367C (en) Prosthesis for preventing gastro-oesophageal reflux
US20050228505A1 (en) Device and method for treating gastroesophageal reflux disease
EP1411867B1 (en) Prosthesis having a sleeve valve
JP4278900B2 (en) Single control gastric band
EP2112912B1 (en) Prosthesis having a sleeve valve
ES2309013T3 (en) LOOSE GASTROPLASTY RING.
US5306300A (en) Tubular digestive screen
US20030009236A1 (en) Prosthesis for controlling the direction of flow in a duct of a living organism
JPS6159730B2 (en)
US20220257257A1 (en) Implantable sphincter assistance device with deformable elements
JP2008528206A (en) Prosthesis with sleeve valve
CN102551938B (en) Instrument for delaying gastric emptying and regulating pancreatic metabolism
WO2023219577A1 (en) Small intestinal area reducing device for non-surgical obesity treatment
CN1203813C (en) Artificial cardia
WO1998010718A1 (en) Voice prosthesis with biomedical sealing on the circumference
Selvais et al. An Unusual Etiology of Abdominal Meteorism: Aerophagia