AU6287894A - Inducible nitric oxide synthase and gene therefor - Google Patents

Inducible nitric oxide synthase and gene therefor

Info

Publication number
AU6287894A
AU6287894A AU62878/94A AU6287894A AU6287894A AU 6287894 A AU6287894 A AU 6287894A AU 62878/94 A AU62878/94 A AU 62878/94A AU 6287894 A AU6287894 A AU 6287894A AU 6287894 A AU6287894 A AU 6287894A
Authority
AU
Australia
Prior art keywords
nitric oxide
oxide synthase
inducible nitric
gene therefor
therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU62878/94A
Inventor
Ian George Charles
Salvador Enrique Moncada
Richard Michael John Palmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of AU6287894A publication Critical patent/AU6287894A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C12N9/0075—Nitric-oxide synthase (1.14.13.39)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13039—Nitric-oxide synthase (NADPH dependent) (1.14.13.39)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU62878/94A 1993-03-26 1994-03-25 Inducible nitric oxide synthase and gene therefor Abandoned AU6287894A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9306386 1993-03-26
GB939306386A GB9306386D0 (en) 1993-03-26 1993-03-26 Gene expression
PCT/GB1994/000621 WO1994023038A1 (en) 1993-03-26 1994-03-25 Inducible nitric oxide synthase and gene therefor

Publications (1)

Publication Number Publication Date
AU6287894A true AU6287894A (en) 1994-10-24

Family

ID=10732852

Family Applications (1)

Application Number Title Priority Date Filing Date
AU62878/94A Abandoned AU6287894A (en) 1993-03-26 1994-03-25 Inducible nitric oxide synthase and gene therefor

Country Status (3)

Country Link
AU (1) AU6287894A (en)
GB (1) GB9306386D0 (en)
WO (1) WO1994023038A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5658565A (en) * 1994-06-24 1997-08-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Inducible nitric oxide synthase gene for treatment of disease
US5830461A (en) * 1992-11-25 1998-11-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education Methods for promoting wound healing and treating transplant-associated vasculopathy
DE4411402A1 (en) * 1994-03-31 1995-10-05 Juergen Schrader DNA expression vectors for use in gene therapy treatment of vascular diseases
WO1996040785A1 (en) * 1995-06-07 1996-12-19 Merck & Co., Inc. Monospecific antibodies and methods using them
EP0831714A1 (en) * 1995-06-07 1998-04-01 Merck & Co., Inc. Monospecific antibodies and methods using them
US5744340A (en) * 1995-06-09 1998-04-28 Schering Corporation Expression of human inducible nitric oxide synthase
US5908842A (en) * 1995-12-08 1999-06-01 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
US7198904B1 (en) * 1996-04-12 2007-04-03 Robert Webber Immunoassay method employing monoclonal antibody reactive to human iNOS
US6531578B1 (en) * 1996-04-12 2003-03-11 Robert Webber Immunoassay method employing monoclonal antibody reactive to human iNOS
WO1998012313A1 (en) * 1996-09-20 1998-03-26 Suntory Limited Method for screening compounds regulating the expression of human-inducible nitric oxide synthase
US6090839A (en) * 1996-12-23 2000-07-18 Merck & Co., Inc. Antidiabetic agents
US6160000A (en) * 1996-12-23 2000-12-12 Merck & Co., Inc. Antidiabetic agents based on aryl and heteroarylacetic acids
FR2793142A1 (en) * 1999-05-04 2000-11-10 Aventis Pharma Sa Antisense oligonucleotides of an inductible isoform of nitrogen monoxide synthase, used to treat cerebral ischemia
AU5081200A (en) * 1999-05-04 2000-11-17 Aventis Pharma S.A. Use of inducible no-synthase antisense oligonucleotides for preventing and treating cerebral ischemia
JP2003520042A (en) * 2000-01-24 2003-07-02 アイシス・ファーマシューティカルス・インコーポレーテッド Antisense modulation of inducible nitric oxide synthase expression
WO2001066791A1 (en) * 2000-03-10 2001-09-13 Fujisawa Pharmaceutical Co., Ltd. Method of screening inducible nitric oxide synthase activation inhibitor

Also Published As

Publication number Publication date
WO1994023038A1 (en) 1994-10-13
GB9306386D0 (en) 1993-05-19

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