AU624119B2 - Container for liquid observed for impurities - Google Patents
Container for liquid observed for impurities Download PDFInfo
- Publication number
- AU624119B2 AU624119B2 AU30537/89A AU3053789A AU624119B2 AU 624119 B2 AU624119 B2 AU 624119B2 AU 30537/89 A AU30537/89 A AU 30537/89A AU 3053789 A AU3053789 A AU 3053789A AU 624119 B2 AU624119 B2 AU 624119B2
- Authority
- AU
- Australia
- Prior art keywords
- container
- container according
- colour
- liquid
- areas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000007788 liquid Substances 0.000 title claims description 46
- 239000012535 impurity Substances 0.000 title claims description 11
- 239000012217 radiopharmaceutical Substances 0.000 claims description 7
- 229940121896 radiopharmaceutical Drugs 0.000 claims description 7
- 230000002799 radiopharmaceutical effect Effects 0.000 claims description 7
- 239000011521 glass Substances 0.000 claims description 4
- 230000004927 fusion Effects 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 2
- 239000012780 transparent material Substances 0.000 claims description 2
- 238000007689 inspection Methods 0.000 description 13
- 239000002245 particle Substances 0.000 description 10
- 238000001514 detection method Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000011179 visual inspection Methods 0.000 description 4
- 238000011109 contamination Methods 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 239000000919 ceramic Substances 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000003708 ampul Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000005355 lead glass Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/90—Investigating the presence of flaws or contamination in a container or its contents
- G01N21/9018—Dirt detection in containers
- G01N21/9027—Dirt detection in containers in containers after filling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D23/00—Details of bottles or jars not otherwise provided for
- B65D23/12—Means for the attachment of smaller articles
- B65D23/14—Means for the attachment of smaller articles of tags, labels, cards, coupons, decorations or the like
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/8803—Visual inspection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0078—Testing material properties on manufactured objects
- G01N33/0081—Containers; Packages; Bottles
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Sampling And Sample Adjustment (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
I'
J
PcTf OPI DATE 11/08/8:9 APPLN. I D "30537 89 PCT NUMBER PCTUS89100262 INTERNATIONM..APPLIC, AOJP DATE 07/09/89 (51) International Patent Classification COIN 21/90 t~ )In na i 9 Publication Num br (.Int at; P0iication Date: WO 89/ 06793 27 July 1989 (27.07.89) (21) International Application Number: PCT/US89/00262 (22) International Filing Date: 23 January 1989 (23,01.89) (81) Designated States: AT (European patent), AU, BE (European patent), CH (European patent), DE (European patent), FR (European patent), GB (European patent), IT (European patent), JP, LU (European patent), NL (European patent), SE (European patent), us.
Published With international search report.
(31) Priority Application Number: 8800154 (32) Priority Date: (33) Priority Country: 25 January 1988 (25.0 1.88) (711) Applicant (for all designated States except US): MAL- LINCKRODT, INC. [US/US]; 675 McDonnell Boulevard, St. Louis, MO 63134 (US), (72) Inventor; and Inventor/Applicant (for US only,) VAN DER GRIFT, Johannes, Franciscus, Jacobus Rembrandilaan 11, NL-1741 KG Schagen (NL).
(74) Agents: BONNER, Grace, L. et al.; Mallinckrodt, Inc,, 675 McDonnell Blvd., St, Louis, MO 63134 (US).
(54) Title: CONTAINER FOR LIQUID OBSEI VED FOR IMPURITIES 4b~ 4.' (57) Abstract The Invention relates to a substantially transparent container for liquids on one side of which ave opaque light and opaque dark, areas of color 4) observable throt:, h the container for evaluating contained- liquid for particulate Im-~ puril es. The container Is particularly useful for phj~rmih1-eutlcaI liquids.
WO 89/06793 PCT/US89/00262 1 CONTAINER FOR LIQUID OBSERVED FOR IMPURITIES Field of the Invention The invention relates to a container for liquids that are evaluated for particulate impurities by visual or mechanical means.
Background of the Invention Many different liquids must be packaged and sealed under conditions that prevent contamination of the liquid by undesired particles. The liquids may be destined for use as reagents in analytical or diagnostic techniques requiring ultra-high purity or for administration as diagnostic or therapeutic pharmaceuticals. In preparing and packaging such liquids, extensive precautions are taken to prevent contamination by undesired particles. After preparation, the liquid is dispensed to containers which are then sealed. It is during packaging that contamination by undesired particles may occur in spite of precautions. These particles may render the liquid less valuable or inoperable for their intended purposes or may constitute a source of danger, in particular in a pharmaceutical liquid for parenteral administration to a patient. In these cases, examination of each container, after sealing, is a compulsory requirement.
Various measures have been suggested to inspect liquids dispensed in containers for the presence of undesired particles. A conventional examination method is a visual inspection which, although easy to perform and sufficiently reliable, is rather time-consuming. In such an inspection, the liquid is preferably illuminated with an artificial light source, either directly or indirec!tly.
The filled containers, after the liquid has been put in 1 1 WO 89/06793 PCT/US89/00262 -2 motion, usually are held successively against a black and a white background, so that light-colored and dark-colored particles, if any, in the liquid become visible. In such an inspection, it is desirable to keep the inspection time per container as short as possible, without comoromising the reliability of detection, merely for economic reasons.
However, shortening of the time necessary fo7 inspection is of prime importance when viewing or visually inspecting containers having a radioactive liquid for reasons of safety. Although the observer's eye is protected as well as possible during viewing from radiation by, for example, positioning a transparent shield of lead-glass between the observer and the container to be inspected, it cannot be entirely prevented. So the exposure time, the time in which the observer is exposed to radiation from the container, must be minimized.
In another usual method of inspecting liquids dispensed in containers for the presence of undesired particles, suitable illuminating means and a detection apparatus are used. By illuminating the liquid in the container in a special manner with the light of a carefully selected light source and then determining the intensity of the transmitted or scattered light by means of, for example, a photosensitive cell, a camera or a video camera with display screen, an impression can be gained about the extent to which the liquid has been contaminated with particles. Such an inspection device is disclosed in U.S. Patent 4,676,650.
These and similar devices are not only complex and hence sensitive to disturbances, and expensive as regards acquisition and maintenance, but they are also not always satisfactory with regard to reliability and detection sensitivity.
L
-3- It is the object of the present invention to provide a more simple and reliable means of examining liquids for impurities which can be used universally, both for visual inspection and for use with detection apparatus, and by which the examination can be facilitated so that the inspection time can be shortened as compared with the known visual inspection methods, It is a further object to provide the means to more easily inspect liquids some time after packaging for changes such as sedimentation, cryst."ization, or gelling, S* 10 SUMMARY OF THE INVENTION: The present invention meets the above described objects by providing S. contrasting dark and light coloured backgrounds against which a liquid is i observed by applying to or incorporating in the container opaque areas of colour. This is accomplished by adding the coloured areas to a part of a side of a substantially transparent container for the liquid. The advantage of this invention lies in that a single observation will detect both light and dark particulate impurities and in that light beam distortion through curved walls is avoided.
Accordingly, the invention provides a container for a radiopharmaceutical liquid which can be easily examined for multicoloured, particulate impurities in said radiopharmaceutical liquid, comprising a container having a substantially transparent side and bottom, part of said RA4 side having contrasting light and dark areas of colour against which said mwspe#5668 92 2
A
"4w., i 3Aradiopharmaceutical liquid is observed and which block passage of light enabling a single observation to detect both light and dark impurities in said radiopharmaceutical liquid.
BRIEF DESCRIPTION OF THE DRAWING: Figure 1 is a side view of a container according to the invention.
Reference numeral 1 in the drawing denotes a sealed vial which contains a liquid 2. The wall of the vial comprises a rectangular area which is partly white 3 and black 4 and which has been provided in the glass wall by ceramic fusion printing. For inspection of the liquid 9..
9 9* 9.
4 99 9 99 99..
49 9; 9 ,eNT 4 mwspe#5668 92 2 20 ii WO 89/06793 PCT/US89/00262 4 the vial is illuminated with the light of a light source through the flat bottom, the light source being positioned beneath the vial. The place of the observer's eye 6 is also shown in the drawing.
Detailed Description of the Invention The invention is a container which provides the means of observing contained liquid for particulate impurities. The container is composed of substantially transparent material for its side wall or walls. It may also have a transparent bottom. Opaque, contrasting areas of color are provided on a part of a side wall. Preferably one white area and one black area are provided. They are preferably rectangular in shape and immediately adjacent to one another.
The areas of color may cover a varying portion of the side area of the contaiener. There must be a portion left transparent for the observation to be made, but the minimum and maximum limits and the preferred total area of color may vary for different forms and sizes of containers. The means of observation to be used will also be determinative. For a cylindrical container a preferred configuration is to cover one half of the side wall with color, half of the area being a light rectangle and half being a dark rectangle, more preferably being white and black, respectively.
The areas of color may be provided in a number of ways. For example, a label may be placed on the outside of the container which has the color areas printed on the reverse side, thereby visible through the container.
Permanent application to the container may be made by fusing the color to the side wall, preferably to the c
P
ii i:i ii i f i 1 WO 89/06793 PCT/US89/00262 exterior of the container. The colored areas are then not liable to be removed, damaged or become dirty during handling and filling. This fusing may be accomplished by etching or ceramic fusion printing, for example, Labelling over the colored areas may then be made either before or after inspection. Problems with identification of the contents of the container are prevented by an early labelling. By providing the label over the contrasting color areas, the field of sight during the inspection is not limited, nor does the necessity exist of inspecting the contents of the container at a given angle with the possibility of annoying reflections at the glass.
The container must be substantialy transparent through the remainder of the side wall or walls, and preferably through the bottom. It may be composed of a variety of materials, chosen for compat'ility with tha contained liquid and other reasons such as cost. Glass is a preferred container composition for pharmaceutical liquids.
The shape of the container is chosen according to the function and properties of the liquid. Examples of suitable container shapes are vials, ampules, bottles, and test tubes. However, the conformation of the container is not limited by the present invention, only by the characteristics and use of the contained liquid.
The advantages of the container having contrasting color areas according to the invention become most prominent during use, that is, when the container has been filled with a liquid and closed or sealed. For inspecting WO 89/06793 PCT/US89/00262 -6the contents for the presence of undesired particles, the liquid is put in motion and the container, with the colored area to the rear, is placed at eye level of the observer or at the level of the detection apparatus used, while the liquid 1s illuminated, preferably through the bottom of the container, that is, perpendicular to the direction of observation. Such an illumination through a preferably flat bottom leads to sharper light beams and clearer scattering by the particles, while annoying reflections in the case of light through the curved wall are avoided. As a result of this the quality of the evaluation, both after visual and after instrumental observation, is improved. The contrasting dark and light colored areas serve as a background iror the liquid to be inspected. As the background is present nearer to the liquid, the contrast between the dark and the light background is sharper. This improves the quality of the observation as compared with the known method in which the container is held successively against a black background and a white background. In addition, when using a container according to the invention, displacement or rotation of the container during the inspection to enable inspection of the contents thereof against a varying background may no longer be necessary. As a result of this, fewer operations are required so that the inspection time is reduced. In visual observation, the eye gets tired less rapidly, while in instrumental observation the detection apparatus need not be refocused again and again.
It will be obvious from the above that, compared with known containers not providing contrasting dark and light colored areas, the container according to the invention provides for a simple and reliable inspection Si t WO 89/06793 PCT/US89/00262 -7that is facilitated so that the time required can be reduced. In addition to visual inspection, the container according to the invention is also suited, as indicated hereinbefore, for instrumental observation, in which photoelectric, photographic or video techniques may be used. The results thus detected can, of course, be processed by means of modern techniques, for example, by means of a computer.
t ii
Claims (15)
1. A container for a radio-pharmaceutical liquid which can be easily examined for multicoloured, particulate impurities in said radiopharmaceutical liquid, comprising a container having a substantially transparent side and bottom, part of said side having contrasting light and dark areas of colour against which said radiopharmaceutical liquid is observed and which block passage of light enabling a single observation to detect both light and dark impurities in said radiopharmaceutical liquid,
2. A container according to claim 1, wherein said container has a S. 10 transparent bottom,
3, A container according to claim 2, wherein said bottom is V. a. substantially flat. %5
4, A container according to claim 2, wherein said side and bottom are glass.
5. A container according to claim 2, wherein said side and bottom are a transparent material, a
6. A container according to claim 2, wherein said contrasting areas of colour are white and black,
7. A container according to claim 6, wherein said contrasting areas of colour are rectangular in shape,
8. A container according to claim 2, wherein an xterior label is applied to said container to provide said contrasting areas of colour. 4R r 9,
9 A container according to claim 1 wherein said contrasting areas of mwspc#5668 92 2 -9- colour are fused to said side.
A container according to clainm wherein said contrasting areas of colour are etched on said side.
11. A container according to claim 9, wherein said contrasting areas of colour are fusion printed on said side.
12. A container according to claim 9, further comprising a label which covers said contrasting areas of colour.
13, A container according to claim 2, wherein said container is a vial for pharmaceuticals. 10
14, A container according to any one of claims 1 to 13 substantially as hereinbefore described, DATED this 20 February 1992 CARTER SMITH BEADLE Fellows Institute of Patent Attorneys )f Australi S
15 Patent Attorneys for the Applicant MALLINCKRODT, INC. mwspe#5668 92 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8800154 | 1988-01-25 | ||
| NL8800154 | 1988-01-25 | ||
| PCT/US1989/000262 WO1989006793A1 (en) | 1988-01-25 | 1989-01-23 | Container for liquid observed for impurities |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU3053789A AU3053789A (en) | 1989-08-11 |
| AU624119B2 true AU624119B2 (en) | 1992-06-04 |
Family
ID=26646340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU30537/89A Ceased AU624119B2 (en) | 1988-01-25 | 1989-01-23 | Container for liquid observed for impurities |
Country Status (1)
| Country | Link |
|---|---|
| AU (1) | AU624119B2 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU493266A (en) * | 1967-05-01 | 1965-11-07 | Commonwealth Of Australia | Detection of particulate contamination in transparent fluids |
| US4227615A (en) * | 1979-05-02 | 1980-10-14 | Flick Gervase M | Medicine container |
| US4402612A (en) * | 1980-11-17 | 1983-09-06 | Alexander Jury V | Apparatus for detecting foreign particles in a liquid |
-
1989
- 1989-01-23 AU AU30537/89A patent/AU624119B2/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU493266A (en) * | 1967-05-01 | 1965-11-07 | Commonwealth Of Australia | Detection of particulate contamination in transparent fluids |
| US4227615A (en) * | 1979-05-02 | 1980-10-14 | Flick Gervase M | Medicine container |
| US4402612A (en) * | 1980-11-17 | 1983-09-06 | Alexander Jury V | Apparatus for detecting foreign particles in a liquid |
Also Published As
| Publication number | Publication date |
|---|---|
| AU3053789A (en) | 1989-08-11 |
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