AU6158100A - Oral form of administration containing probiotic micro-organisms - Google Patents
Oral form of administration containing probiotic micro-organisms Download PDFInfo
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- AU6158100A AU6158100A AU61581/00A AU6158100A AU6158100A AU 6158100 A AU6158100 A AU 6158100A AU 61581/00 A AU61581/00 A AU 61581/00A AU 6158100 A AU6158100 A AU 6158100A AU 6158100 A AU6158100 A AU 6158100A
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- Australia
- Prior art keywords
- oral administration
- administration form
- shellac
- form according
- coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
An Oral Administration Form The invention relates to an oral administration form containing at least one genus of probiotic microorganisms, said administration form itself and/or said probiotic micro organisms having at least one enteric coating. Many people, particularly in economically and indus trially highly developed nations, frequently complain of temporary or chronic indigestion caused by a damaged or im paired intestinal flora. These "diseases of the affluent society" mostly are caused by stress situations, abuse of medications or drugs, consecutive symptoms of treatments with antibiotics, but also by malnutrition in many cases. Acute and severe symptoms can be treated using well-known drugs which may contain not only suitable pharmaceutical active substances but also appropriate natural enzymes or intestine specific microorganisms. However, in case of chronic, mild disorders of the intestinal tract not actually to be referred to as a disease, habitual consumption of suitable, selected foods or dietary supplementing preparations based on probiotic microorganisms frequently is sufficient to alleviate or eliminate the symp toms caused by an impaired or damaged intestinal flora. Even in case of an intact or healthy intestinal flora, the supply of probiotic microorganisms, particularly in combination with antioxidants, may have an immunostimulating effect. For these reasons, yoghurt and curdled milk products become more and more popular. However, most of these products which are valuable in nutrition and include suitable pro biotic microorganisms for this purpose are fresh products and -2 can only be stored under refrigeration, and even in this event, for just a few days. Furthermore, there are products presenting suitable probiotic microorganisms in the form of a monopreparation. However, these products involve the disadvantage of lacking approval as food or food supplement in many countries because they do not contain any further nutrition-physiologically valuable substances such as minerals, fats, vitamins, carbo hydrates, proteins, roughage, or trace elements. Moreover, an average of only about 10% of the ingest ed probiotic microorganisms are capable of developing their healthful activity in the human or animal intestine. There fore, a substantially larger amount of probiotic microorgan isms than required in therapeutic terms has to be ingested in order to achieve a sufficiently high activity of these pro biotic microorganisms in the human and animal intestine and thus, a healthful effect. It was therefore the object of the invention to in crease the activity of probiotic microorganisms in the human and/or animal intestine and thus, their healthful effect as well. According to the invention, said object is accom plished by providing an oral administration form containing at least one genus of probiotic microorganisms, said adminis tration form itself and/or said probiotic microorganisms having at least one enteric coating. The oral administration preferably is a tablet, a coated tablet, a capsule, a granulate, or a powder, more preferably a tablet, with multilayer tablets being particu larly preferred.
-3 All those microorganisms are suitable as probiotic microorganisms which themselves normally occur in a healthy human or animal intestine and/or have a healthful effect on a healthy, impaired or diseased intestinal tract. For exam ple, probiotic microorganisms promote the intestinal diges tion of lactose in individuals exhibiting a lactose incompat ibility, or promote more rapid convalescence from various diarrhetic diseases. Preferably, the probiotic microorganisms employed are lactobacilli, bifidus bacteria, or streptococci, with Lactobacillus case, Lactobacillus acidophilus, Bifido bacterium bifidum, Bifidobacterium longum, and/or Lactobacil lus plantarum being particularly preferred. The amount of probiotic microorganisms in the oral administration form of the invention is to be selected in a way so as to ensure the desired healthful effect. The oral administration form of the invention preferably contains from 103 to 1012, more preferably from 105 to 1011 probiotic micro organisms, with 107 to 1010 being particularly preferred. For stability with respect to number and activity of living mi croorganisms, the materials used, particularly the carrier material having embedded the probiotic microorganisms there in, advantageously have a water content as low as possible. The water content preferably is 3.0 wt.-%, more preferably 50.1 wt.-%, relative to the weight of the carrier material. According to the invention, the oral administration form has at least one enteric coating. In a preferred embodi ment, the oral administration form of the invention has at least one coating essentially consisting of shellac or of shellac and polyvinylpyrrolidone. In another preferred embodiment, the oral administra tion form of the invention has at least one coating comprised of at least two layers, one layer essentially consisting of hydroxypropylmethylcellulose, methylcellulose and/or polyvi- -4 nylpyrrolidone, and/or one layer essentially consisting of shellac or of shellac and polyvinylpyrrolidone. In another preferred embodiment, the oral administra tion form of the invention has at least one coating comprised of at least two layers, the/one inner layer in the proximity of the core essentially consisting of hydroxypropylmethyl cellulose, methylcellulose and/or polyvinylpyrrolidone, and/or the/one outer, off-core layer essentially consisting of shellac or of shellac and polyvinylpyrrolidone. The oral administration form of the invention prefer ably includes from 1 to 10 wt.-% shellac, more preferably from 1.5 to 6 wt.-%, relative to the total weight of the oral administration form, with 2 - 3.5 wt.-% being particularly preferred. Essentially, the oral administration form of the invention has an enteric coating of at least such a size so as to entirely enclose the probiotic microorganisms. Another preferred embodiment of the oral administra tion form includes probiotic microorganisms which themselves are provided with an enteric coating. To this end, the pro biotic microorganisms are dried using various methods well known to those skilled in the art and subsequently provided with at least one enteric coating. Also, in addition to the enteric coating(s), the inventive oral administration form itself and/or the pro biotic microorganisms optionally may have one or more addi tional coating(s). Preferably, this/these coating(s) serves/serve to achieve improved adherence of the enteric coating(s) and/or improved flavor, stability and/or optical appearance.
-5 The coatings can be coated both from an aqueous solu tion and from an organic solution. As for the oral adminis tration form of the invention, it is advantageous to coat the first coating, i.e., the first or inner layer close to the core from an organic solution because the probiotic microor ganisms frequently are highly sensitive to moisture. It is particularly advantageous to coat the coatings or layers from an alcoholic solution of the coating materials. In another preferred embodiment, the oral administra tion form of the invention includes further nutritionally relevant additives in addition to the probiotic microorgan isms. Preferably, it includes vitamins, minerals, trace ele ments, roughage, enzymes, vegetable extracts, proteins, car bohydrates, and/or fats. In case the oral administration form includes nutritionally relevant additives, such as proteins, which already begin to undergo digestion in the stomach, it is important that these nutritionally relevant additives are at least not entirely enclosed by an enteric coating. Depending on the nutritionally relevant additives used, it may be necessary to incorporate each of these and/or each of these and the probiotic microorganisms in the oral administration form of the invention in a way so as to avoid contact with each other. In a preferred fashion, this is accomplished by incorporating the nutritionally relevant additives and/or microorganisms in different layers of a multilayer tablet. Preferred vitamins are vitamin A (1-carotene), vita min C, vitamin E, B complex vitamins, and/or vitamin K. Par ticularly preferred vitamins are vitamin A, vitamin C and/or vitamin E. As a rule, the amounts of these vitamins depend on the recommended minimum required dose for the respective vitamin, but these amounts may also be exceeded by 50 - 200% on an average. A preferred range for vitamin C is between 50 -6 and 300 mg, for vitamin E from 10 to 50 mg, for vitamin A 51.5 mg, and for the B complex vitamins from 10 gg to 20 mg. Preferred minerals are edible inorganic or organic salts of sodium, potassium, calcium, magnesium, zinc, and/or iron, preferably present as carbonates, bicarbonates, phos phates, biphosphates, sulfates, bisulfates, chlorides, fluo rides, citrates, and/or lactates. The amount of minerals relative to the total weight of the oral administration form preferably is from 20 to 40 wt.-%. The oral administration form of the invention preferably includes silicon, chromium, manganese, iodine, molybdenum, selenium, and/or copper as trace elements. The oral administration form of the invention prefer ably includes soy bran, corn bran, wheat bran, and/or grain shot as roughage, with soy bran being particularly preferred. The amount of roughage relative to the total weight of the oral administration form preferably is from 2 to 50 wt.-%. Preferred enzymes and coenzymes are lipases and/or proteases, and coenzyme Q, superoxide dismutase and/or gluta thione peroxidase which promote the function of stomach and/or intestine and/or the metabolism. They may be incorpo rated in per se known amounts and in a per se known form. In addition, the oral administration form includes further probiotic substances, preferably oligofructose and/or other oligosugars. Preferably, the vegetable extracts are dry extracts from Echinaceae, bioflavonoids, polyphenols, phytoestrogens, and/or saponins. Preferably, the oral administration form of the in vention includes soy protein and/or whey protein as proteins, -7 and/or as fats those fats which contain polyunsaturated fatty acids. Depending on the respective embodiment, the oral administration form of the invention may also include conven tional adjuvants and additives. The selection of adjuvants and/or additives also depends on the food-related regulations in that country where the oral administration form of the invention is to be used. Particularly in its coating, the oral administration form of the invention preferably includes plasticizers such as glycerol, Miglyol, mold wax, and/or acetylated monoglycerides as additional adjuvants. Starch (e.g., corn starch), talc, microcrystalline cellulose, lactose, highly dispersed silica, polyvinylpyrrol idone, and/or cellulose powder are used as additional adju vants and/or additives e.g. in the tablets, multilayer tab lets, coated tablets of the invention. As further components, carbohydrates such as mannitol, sorbitol, xylitol, glucose, sucrose, fructose, maltose, dextrose, maltodextrin, and/or kaolin, and/or cellulose derivatives such as methylcellulose, hydroxypropylcellulose and/or hydroxypropylmethylcellulose, and/or calcium carbonate, calcium, magnesium and/or glycerol stearate can be used as binders and/or antitack agents. In addition, the oral administration form of the invention may also include colorants, flavors and/or aromatic substances, as well as lubricants, antioxidants and/or stabilizers. On the one hand, the amount of these basic substances depends on the desired content of probiotic microorganisms, vitamins, enzymes, roughage, etc. and, on the other hand, on criteria determining the mechanical-physical properties of the oral administration form, such as hardness, compactibility, size, color, and/or shape. The oral administration form of the invention can be produced according to methods well-known to those skilled in the art. For example, these methods are known from H. Sucker, -8 P. Fuchs, P. Speisser, "Pharmazeutische Technologie", Stutt gart, 1978; or K.H. Farmer, K.H. Frbmming, C. Fuhrer, "Phar mazeutische Technologie", Stuttgart, 1986. They are hereby incorporated by reference and thus, represent part of the disclosure. The invention is also directed to methods of produc ing an oral administration form of the invention, character ized in that the coating(s) is/are coated from an aqueous solution and/or from an organic solution, preferably from an organic solution, and more preferably from an alcoholic solu tion. The coatings can be coated using conventional methods well-known to those skilled in the art, e.g. tablet coating, spraying of solutions, dispersions or suspensions, or by powder coating procedures. The oral administration form of the invention is advantageous in that a substantially smaller amount of pro biotic microorganisms is required to achieve the desired healthful effect. As a result, it can be produced much more cheaply. Examples The following examples are intended to illustrate the invention without limiting the general idea thereof. Example 1 A mixture of 65% bacteria preparation, 6% microcrys talline cellulose, 20% tricalcium phosphate, 2% glyceryl palmitostearate, 0.6% magnesium stearate, and 6.4% disinte grant was compacted together with a mixture of vitamins and -9 minerals on an eccentric press El by Fette Company or KS by Kilian Company to form an oblong tablet having a core weight of 1.35 g and the dimensions 20.0 mm x 8.8 mm x 7.0 mm. To produce the enteric coating, shellac was initially dissolved in ethanol with stirring and as soon as a clear solution was obtained, Miglyol was added to the solution and stirring was continued for another 15 minutes. This solution was subse quently coated onto the tablet, using a Schlick nozzle. The process parameters were selected in a way so as to obtain homogeneous film coating. The amount of shellac was 2.1 wt.-% relative to the weight of the core, corresponding to 4.5 mg per cm 2 tablet surface. Example 2 A mixture of 10% bacteria preparation, 33% lactose, 48.4% microcrystalline cellulose, 2% glyceryl palmito stearate, 0.6% magnesium stearate, and 6.0% disintegrant was compacted together with a mixture of vitamins and minerals on a rotary pelleter by Manesty Company to form an egg-shaped tablet having a core weight of 1.0 g and the dimensions 18.0 mm x 8.8 mm x 7.2 mm. Thereafter, a film of hydroxy propylmethylcellulose was coated thereon by spraying an eth anolic solution. The amount of coated hydroxypropylmethylcel lulose was 0.8 wt.-% relative to the weight of the core, corresponding to 1.4 mg per cm 2 tablet surface. Then, also by spraying an ethanolic solution, another enteric coating com prised of shellac, polyvinylpyrrolidone and acetylated mono glycerides was coated over this first layer of hydroxypropyl methylcellulose. The amount of shellac was between 0.25 and 0.35 wt.-% relative to the weight of the core, corresponding to 4.5 mg/cm2 - 6.3 mg/cm2 tablet surface. The amount of acetylated monoglycerides and polyvinylpyrrolidone was 14.2 wt.-% each, relative to the amount of shellac employed.
- 10 Example 3 A mixture of 65% bacteria preparation, 6% microcrys talline cellulose, 20% tricalcium phosphate, 2% glyceryl palmitostearate, 0.6% magnesium stearate, and 6.4% disinte grant was compacted together with a mixture of vitamins and minerals on a rotary pelleter by Hata Company to form an egg shaped tablet having a core weight of 1.35 g and the dimen sions 21.0 mm x 10.0 mm X 8.0 mm. Thereafter, a film of hydroxypropylmethylcellulose and glycerol or Miglyol was coated thereon by spraying an ethanolic solution. The amount of coated hydroxypropylmethylcellulose was 0.8 wt.-% relative to the weight of the core, corresponding to 1.48 mg per cm 2 tablet surface. The amount of glycerol or Miglyol was 10 wt.-% relative to the amount of hydroxypropylmethylcellu lose employed. Likewise by spraying an ethanolic solution, another enteric coating comprised of shellac, polyvinylpyr rolidone and acetylated monoglycerides was coated over this first layer of hydroxypropylmethylcellulose. The amount of coated shellac was between 0.3 and 0.5 wt.-% relative to the weight of the core, corresponding to 4.1 mg/cm2 - 6.8 mg/cm 2 tablet surface. The amount of acetylated monoglycerides and polyvinylpyrrolidone was 14.2 wt.-% each, relative to the amount of shellac employed.
Claims (11)
1. An oral administration form containing at least one genus of probiotic microorganisms, characterized in that the administration form itself and/or the probiotic microorganisms has/have at least one enteric coating.
2. The oral administration form according to claim 1, characterized in that the oral administration form is a tablet, a coated tablet, a capsule, a granulate, or a powder, preferably a tablet, and more preferably a multi layer tablet.
3. The oral administration form according to claim 1 or 2, characterized in that the probiotic microorgan isms are lactobacilli, bifidus bacteria, or streptococci, preferably Lactobacillus case, Lactobacillus acidophi lus, Bifidobacterium bifidum, Bifidobacterium longum, and/or Lactobacillus plantarum.
4. The oral administration form according to one or more of claims 1 to 3, characterized in that it contains from 103 to 1012, preferably from 105 to 1011, more pref erably from 107 to 1010 probiotic microorganisms.
5. The oral administration form according to one or more of claims 1 to 4, characterized in that the enteric coating essentially consists of shellac or of shellac and polyvinylpyrrolidone.
6. The oral administration form according to one or more of claims 1 to 4, characterized in that the coating is comprised of at least two layers, one layer essential ly consisting of hydroxypropylmethylcellulose, methylcel lulose and/or polyvinylpyrrolidone, and/or one layer - 12 essentially consisting of shellac or of shellac and poly vinylpyrrolidone.
7. The oral administration form according to claim 6, characterized in that the coating is comprised of at least two layers arranged one on top of the other, the/one inner layer in the proximity of the core essen tially consisting of hydroxypropylmethylcellulose, meth ylcellulose and/or polyvinylpyrrolidone, and/or the/one outer, off-core layer essentially consisting of shellac or of shellac and polyvinylpyrrolidone.
8. The oral administration form according to one or more of claims 5 to 7, characterized in that the amount of shellac is from 1 to 10 wt.-%, preferably from 1.5 to 6 wt.-%, and more preferably from 2 to 3.5 wt.-%.
9. The oral administration form according to one or more of claims 1 to 8, characterized in that it contains further nutritionally relevant additives, preferably vitamins, minerals, trace elements, roughage, enzymes, vegetable extracts, proteins, carbohydrates, and/or fats.
10. The oral administration form according to one or more of claims 1 to 9, characterized in that it contains additional adjuvants, particularly in its coating(s), preferably plasticizers, more preferably glycerol, Miglyol, mold wax, and/or acetylated monoglycerides.
11. A process for producing the oral administration form according to one or more of claims 1 to 10, charac terized in that the coating is coated from an aqueous solution and/or from an organic solution, preferably from an organic solution, and more preferably from an alcohol ic solution.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19937361A DE19937361A1 (en) | 1999-08-12 | 1999-08-12 | Oral dosage form |
DE19937361 | 1999-08-12 | ||
PCT/EP2000/006580 WO2001012164A1 (en) | 1999-08-12 | 2000-07-12 | Oral form of administration containing probiotic micro-organisms |
Publications (2)
Publication Number | Publication Date |
---|---|
AU6158100A true AU6158100A (en) | 2001-03-13 |
AU770792B2 AU770792B2 (en) | 2004-03-04 |
Family
ID=7917589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU61581/00A Ceased AU770792B2 (en) | 1999-08-12 | 2000-07-12 | Oral form of administration containing probiotic micro-organisms |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1207859B1 (en) |
JP (1) | JP2003506481A (en) |
KR (1) | KR20020031383A (en) |
CN (1) | CN1364076A (en) |
AR (1) | AR025020A1 (en) |
AT (1) | ATE276746T1 (en) |
AU (1) | AU770792B2 (en) |
BR (1) | BR0013110A (en) |
CA (1) | CA2377415A1 (en) |
CZ (1) | CZ2002354A3 (en) |
DE (2) | DE19937361A1 (en) |
HK (1) | HK1048065A1 (en) |
HU (1) | HUP0203029A3 (en) |
MX (1) | MXPA02000630A (en) |
NO (1) | NO20020676D0 (en) |
PL (1) | PL353878A1 (en) |
RU (1) | RU2002105484A (en) |
SK (1) | SK1632002A3 (en) |
WO (1) | WO2001012164A1 (en) |
ZA (1) | ZA200110534B (en) |
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JP2859217B2 (en) * | 1995-08-10 | 1999-02-17 | 日清製粉株式会社 | Method for producing granules containing useful intestinal bacteria |
KR100387245B1 (en) * | 1997-10-17 | 2003-08-19 | 일양약품주식회사 | Enteric coated microgranules for stabilizing lactic acid bacteria |
JPH11139978A (en) * | 1997-11-06 | 1999-05-25 | Asahi Beer Yakuhin Kk | Enteric live bacterium preparation |
-
1999
- 1999-08-12 DE DE19937361A patent/DE19937361A1/en not_active Withdrawn
-
2000
- 2000-07-12 AU AU61581/00A patent/AU770792B2/en not_active Ceased
- 2000-07-12 CA CA002377415A patent/CA2377415A1/en not_active Abandoned
- 2000-07-12 KR KR1020027000314A patent/KR20020031383A/en not_active Application Discontinuation
- 2000-07-12 HU HU0203029A patent/HUP0203029A3/en unknown
- 2000-07-12 MX MXPA02000630A patent/MXPA02000630A/en unknown
- 2000-07-12 CZ CZ2002354A patent/CZ2002354A3/en unknown
- 2000-07-12 AT AT00947970T patent/ATE276746T1/en active
- 2000-07-12 BR BR0013110-5A patent/BR0013110A/en not_active IP Right Cessation
- 2000-07-12 EP EP00947970A patent/EP1207859B1/en not_active Expired - Lifetime
- 2000-07-12 JP JP2001516511A patent/JP2003506481A/en active Pending
- 2000-07-12 WO PCT/EP2000/006580 patent/WO2001012164A1/en active IP Right Grant
- 2000-07-12 CN CN00810830A patent/CN1364076A/en active Pending
- 2000-07-12 DE DE50007927T patent/DE50007927D1/en not_active Expired - Lifetime
- 2000-07-12 RU RU2002105484/15A patent/RU2002105484A/en not_active Application Discontinuation
- 2000-07-12 SK SK163-2002A patent/SK1632002A3/en unknown
- 2000-07-12 PL PL00353878A patent/PL353878A1/en unknown
- 2000-08-02 AR ARP000103992A patent/AR025020A1/en not_active Application Discontinuation
-
2001
- 2001-12-21 ZA ZA200110534A patent/ZA200110534B/en unknown
-
2002
- 2002-02-11 NO NO20020676A patent/NO20020676D0/en not_active Application Discontinuation
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2003
- 2003-01-07 HK HK03100151.2A patent/HK1048065A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO20020676L (en) | 2002-02-11 |
ATE276746T1 (en) | 2004-10-15 |
CN1364076A (en) | 2002-08-14 |
RU2002105484A (en) | 2003-11-20 |
EP1207859A1 (en) | 2002-05-29 |
NO20020676D0 (en) | 2002-02-11 |
HK1048065A1 (en) | 2003-03-21 |
MXPA02000630A (en) | 2002-08-30 |
PL353878A1 (en) | 2003-12-01 |
DE50007927D1 (en) | 2004-10-28 |
AU770792B2 (en) | 2004-03-04 |
BR0013110A (en) | 2002-05-07 |
CZ2002354A3 (en) | 2002-05-15 |
HUP0203029A2 (en) | 2002-12-28 |
JP2003506481A (en) | 2003-02-18 |
CA2377415A1 (en) | 2001-02-22 |
KR20020031383A (en) | 2002-05-01 |
ZA200110534B (en) | 2003-07-30 |
SK1632002A3 (en) | 2002-06-04 |
HUP0203029A3 (en) | 2004-10-28 |
EP1207859B1 (en) | 2004-09-22 |
WO2001012164A1 (en) | 2001-02-22 |
DE19937361A1 (en) | 2001-02-22 |
AR025020A1 (en) | 2002-11-06 |
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