AU612004B2 - Cosmetic composition for improving the aesthetic appearance of the skin based on multivitamin mixtures - Google Patents
Cosmetic composition for improving the aesthetic appearance of the skin based on multivitamin mixtures Download PDFInfo
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- AU612004B2 AU612004B2 AU30756/89A AU3075689A AU612004B2 AU 612004 B2 AU612004 B2 AU 612004B2 AU 30756/89 A AU30756/89 A AU 30756/89A AU 3075689 A AU3075689 A AU 3075689A AU 612004 B2 AU612004 B2 AU 612004B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
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- Obesity (AREA)
- Diabetes (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Method for improving the aesthetic aspect of the skin comprises applying daily to the skin a cosmetic compsn contg a mixt of vitamins in a vehicle suitable for a topical applicn and administering orally and daily a prepn also contg a mixt of vehicles in a vehicle suitable for such administration, the method being continued until the desired result is reached. Pref. the method is effected: for 3-5 weeks and pref the compsn. contains a mixt of vitamins E A, B2, B5 and H, and pref. it also contains Vitamins F, D, B6 and/or folic acid.
Description
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i C92004 COMMONWEUALTH OF AUSTRAIAU PATENTS ACT 1952 AME ADDRESS )F APPLICANT: L'Oreal 14, rue Royale 75008 Paris France NAME(S) OFRINVENTOR(S): o Jacqueline GRJAT o Etienne SOTJDANT Arlette ZABOTTO Chantal. FANCHON Francois PRADIER ADDRESS FOR SERVICE:
A
DAVIES COLLISON Patent Attorneys 1 Little Collins Street, Melbourne, 3000.
ft I COMPLETE SPECJFICATION FOR THE INVENTION ENTITLED: Cosmetic composition for improving the aesthetic appearance of the skin based on multivitamiin mixtures The following statement is a full description of this invention, including the best method of performing it known to me/us:- '4 r la- The present invention relates to a cosmetic composition for improving the aesthetic appearance of the skin, especially of the face, based on multivitamin combinations.
It is known that certain balanced combinations of vitamins make it possible to treat people suffering a deficiency in their general condition due to physical or mental 1 0 fatigue, to overexertion or to an imbalanced diet. Furtherr more, such vitamin-based treatments are particularly recommended during periods of growth or pregnancy and during
S.
So convalescence.
*94 These vitamin mixtures, which can also be combined I' 15 with mineral salts and oligo-elements, essentially contain the following vitamins, in therapeutically active doses: A, D2, Bl, B2, B5, B6, C and E as well as nicotinic acid (vita- 9*44 P O min PP) and biotin (vitamin H).
It is also known, from numerous scientific studies, that the skin is a tissue which is particularly sensitive to °o nutrition lacking in vitamins. Deficiency in vitamins from the B group, especially vitamins Bl, B2 and B6 as well as deficiency in vitamins C and A cause skin disorders which manifest themselves as a coarse look of the skin, an absence 25 of elasticity and lack of glow.
In order to overcome these symptoms, cosmetic compositions based on certain lipid-soluble and water-soluble vitamins have been proposed inasmuch as these were sufficiently stable.
Pantothenic acid (vitamin B5) has also been proposed as having a beneficial effect on the skin, although there is no sure proof of penetration through the epidermis.
These vitamin supplements which are either taken orally or applied locally are generally not sufficiently balanced as regards the different vitamins, so that treatments based on multivitamin compositions do not make it possible to improve the aesthetic appearance of the skin,
L
l-'cLdLCU dl Signature of declarant(s) (no attestation required) Note: Initial all alterations.
DAVIES
Andre VIOUT ILBOURNE and CANBERRADirecteur du Dpartement Brevets i 2especially of the face.
After extensive studies carried out in this field, it was found quite surprisingly and unexpectedly that particularly favourable results could be obtained, as far as the aesthetic appearance of the skin was concerned, by using suitable mixtures of vitamins in a cosmetic carrier.
The results obtained have in fact made it possible to show that the multivitamin compositions according to the invention improved the appearance of the skin in a very sig- 10 nificant manner, the skin being smoother, softer and more S. supple to touch.
Furthermore, it was found that the persons thus treated all had a face which had more glow to it and that in o.s addition the skin displayed a better resistance to outside 15 influences.
Therefore, the object of the present invention is a as0 0cosmetic composition for improving the aesthetic appearance S of the skin, characterized by the fact that it contains, in o a suitable cosmetic vehicle, a mixture of vitamins in the S 20 following proportions by weight based on the total weight of the composition:
'I.
as.
a soC *0 C a a a a Vitamin E between 0.3 and 6 Vitamin A between 0.005 and 0.5 Vitamin B2: between 0.001 and 0.01% 25 Vitamin B5: between 0.5 and 3 Vitamin H between 0.01 and 0.05%.
Vitamin E or L-tocopherol, preferably in the form of -tocopherol acetate, is preferably contained in the composition in a quantity of between 1.5 and 5% by weight.
Vitamin A or retinol is preferably contained in the composition in a quantity of between 0.15 and 0.35% by weight.
Vitamin B2 or riboflavin, in the form of its sodium salt of the 5'-phosphate derivative, is preferably contained in the composition in a quantity of between0.002 and 0.008% by weight.
Vitamin B5 or pantothenic acid, preferably in the form 3 of calcium or sodium D-pantothenate, is preferably contained in the composition in a quantity of between 1 and 2% by weight.
Vitamin H or biotin is preferably contained in the composition in a quantity of between 0.015 and 0.03% by weight.
These different percentages are expressed here based on the total weight of the cosmetic composition.
The studies which have been carried out have made it possible to highlight the importance of these different vitamins with regard to the desired cosmetic effect.
oThe cosmetic composition may come in various forms o^ allowing easy application of the composition to the skin, 8 9 S"'a especially on the face.
15 Thus, it may be, for example, a cream, a milk, a serum or an emulsion of the oil-in-water or the water-in-oil type.
Of course, the vehicle of the composition should not have any detrimental effect on the stability of the vitamin S° mixture.
20 The emulsifying agents in these compositions generally make up between 1 and 20% and preferably between 2 and 12% by weight based on the total weight of the composition.
Among the various emulsifiers which can be used may be e*8 mentioned, in particular: 25 esters of polyoxyethylenated or polyglycerolated fatty acids, oxyethylenated or polyglycerolated fatty alcohols such as, for example, oleyl alcohol polyoxyethylenated with moles of ethylene oxide, stearyl alcohol polyoxyethylenated with 10 to 20 moles of ethylene oxide, oleyl alcohol polyglycerolated with 4 moles of glycerol and synthetic fatty alcohols having from 9 to 15 carbon atoms polyoxyethylenated with 5 to 10 moles of ethylene oxide, alkyl sulfates which may or may not be oxyethylenated such as sodium lauryl sulfate, ammonium lauryl sulfate, sodium cetyl stearyl sulfate, triethanolamine cetyl stearyl sulfate, monoethanolamine lauryl sulfate, oxyethylenated f 4 sodium laurylether sulfate (with 2.2 moles of ethylene oxide, for example) and oxyethylenated monoethanolamine laurylether sulfate (with 2.2 moles of ethylene oxide, for example), and soaps such as triethanolamine stearate.
The emulsifying system consisting of magnesium lanolate and alcohol of lanolin and/or hydrogenated lanolin may also be mentioned.
The water phase of the emulsions may optionally contain jellifying agents such as, for example, hydroxypropyl methylcellulose. The oil phase, consisting of at least one Stoil and optionally of at least one wax, varies between approximately 8 and 50% by weight based on the total weight Sf t of the composition.
Among the fatty products constituting the fatty phase S 15 of these compositions may be mentioned: hydrocarbonated oils such as paraffin oil, purcellin oil, perhydrosqualene and solutions of microcrystalline waxes in oils, *o animal or vegetable oils such as oil of sweet almond, avocado oil, calophyllum oil, lanolin, castor oil, horse oil, pig oil, sesame oil, olive oil, jojoba oil, oil of karite, hoplostethus oil, sunflower oil, n.d, mineral oils of which the initial destillation point under atmospheric pressure is approximately 250°C and the 25 final point is about 4100C, saturated or unsaturated esters such as alkyl myristates, for example those of isopropyl, butyl or cetyl, hexadecyl stearate, ethyl or isopropyl palmitates, triglycerides of octanoic and decanoic acid and cetyl ricinoleate.
The cosmetic compositions according to the invention may also contain vitamins other than those mentioned, in particular vitamin F (essential fatty acids), vitamin D, vitamin B6, or folic acid, as well as other substances to maintain and improve the properties of the skin such as, for example, moisturizers, revitalizing agents and protein derivatives.
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-X a~o-I-~ 5 According to a particular embodiment, the cosmetic composition according to the invention contains between 0.005 and 0.025% of folic acid, and preferably between 0.0075 and 0.015%.
Some of the vitamins of the composition may be incorporated in microdispersions of the liposome type.
SIn addition, the composition may also contain colouring agents, perfumes, sun filters, anti-oxidants as well as preservatives such as methyl para-hydroxybenzoate or propyl I 10 para-hydroxybenzoate.
I t It is preferred to apply the cosmetic composition by means of a light massage in order to cause it to penetrate properly, this application preferably being carried out in the evening so as to allow the composition to act and penetrate during the night.
The cosmetic compositions according to the invention have proved to be particularly favourable to improve the aesthetic appearance of the skin.
1) Cream of the water-in-oil type S 20 Vitamin mixtures: Vitamin 1.5 Vitamin 0.3 Vitamin 0.003% Vitamin 1 S" 25 Vitamin 0.02 Vitamin 2 Folic 0.008% Magnesium lanolate 7 Lanolin alcohol 3 Isopropyl 8 Sunflower 30 10 Methyl para-hydroxybenzoate................. 0.2 Propyl para-hydroxybenzoate................. 0.1 Water sufficient to make 100 i" J -6- 2) Emulsion of the oil-in-water type Vitamin mixtures: Vitamin 3 Vitamin 0.2 Vitamin 0-007% Vitamin 2 Vitamin 0.03 Folic 0.015% 10 10 Polyethyleneglycol 3 4 0.6 Oil of sweet 2 Isopropyl 1 Esters of capric and caprylic acid and of C12-C 1 fatty 1 .4.Cetyl 0.5 Stearic 3 Non-emulsifiable glycerol mono- and 3 0.1 0.2 Water sufficient to make 100 4 3) Milk of the oil-in-water type Vitamin mixtures: Vitamin 2 Vitamin 0.15 Vitamin 0.002% Vitamin 2 Vitamin 0.015% oil of 3 Vaseline 8 Glycerol 2 Sorbitan monostearate oxyethylenated with 20 moles of ethylene oxide (Tween 60) Stearic 1.4 7 0.7 Carbopol 940 0.2 Butylated hydroxyanisole/butylated hydroxytoluene 0.1 1 Water preservatives sufficient to make up. 100 4) Milk of the oil-in-water type Vitamin mixture: Vitamin 2.50 10 Vitamin 0.35 Vitamin B2 0.008% f 4 Vitamin 1.50 Vitamin 0.02 *o o0 ,Sorbitan 2.00 Glycerol stearate oxyethylenated with moles of ethylene 2.00 o 'Cetyl alcohol 1.00 Vaseline 10.00 o. o Jojoba 2.00 Carbopol 0.20 0.20 1.00 Methyl para-hydroxybenzoate................. 0.30 SSterile deionized water sufficient to make up 100 According to the invention, it is more particularly recommended to apply every day a cosmetic composition as defined above to the skin and to daily administer orally a preparation also containing a vitamin mixture in a vehicle suitable for such administration, the treatment being continued until the aesthetic appearance of the skin has improved.
The order of application of the compositions is not of major importance, provided, however, that each of them be applied and administered daily during the treatment.
Results which can be clearly observed both visually and by touching are generally obtained after a period of Ai i 1 c" I If rt 4 4t
U-
*444 0 4 #44 4 44 #4 o 40 44 8three to five weeks.
In order not to lose the benefit of the effects obtained, it is recommended in particular to continue treatment in the form of a sustained treatment for a period of 3 to 4 weeks at least once a year and preferably 2 to 3 times a year.
The multivitamin preparation which is administered orally consists essentially of a mixture of vitamins E, A, B2, H, B1 and C.
As can be seen, the oral preparation and the cosmetic composition are characterized essentially by the presence of some of the same vitamins, namely vitamin:, A, E, B2, B5 and
H.
Vitamin A is preferably administered orally in the 15 form of provitamin A ((-carotene).
Vitamin Bl or thiamine is preferably administered in its hydrochloride or nitrate form and vitamin C or Lascorbic acid in the form of its calcium or sodium salts or in the form of ascorbyl palmitate.
20 The daily doses of these vitamins which have to be administered, in one or more doses, are as follows: Provitamin A ((-carotene).... 1.2 to 30 mg Vitamin 3.75 to 30 mg Vitamin 0.3 to 5 mg Vitamin 2.5 to 15 mg Vitamin 0.075 to 0.45 mg Vitamin 0.3 to 2 mg Vitamin to 200 mg The orally administered preparation may also contain other vitamins, especially vitamin D, vitamin PP, vitamin B6 (pyridoxine hydrochloride), as well as certain mineral elements (Se and Cu) and oligo-elements such as for example magnesium glycerophosphate, magnesium citrate, magnesium gluconate, ferrous phosphate, cupric citrate, cupric gluconate, zinc acetate, zinc histidine, zinc gluconate, zinc chloride, selenite salts as well as selenium methionine.
These orally administered compositions may take different forms, especially the form of tablets, a powder, 4404 0 0 4 44 I 9 granules, pills, capsules, gelatin capsules or in the form of a syrup, a suspension or a solution.
Among these different forms those which are especially preferred are capsules and gelatin capsules.
According to a preferred embodiment, the vitamin mixture is combined with at least one edible vegetable oil such as, for example, safflower oil, wheatgerm oil, oil of oenothera seeds, borage oil, oil of blackcurrant seeds, peanut oil, soybean oil, or with an animal oil of marine 10 origin which is rich in polyunsaturated fatty acids.
These oils are particularly recommended inasmuch as .o they provide linoleic acid as well as o-linoleic acid (essential fatty acids).
The orally taken preparation may also contain various So 15 conventional ingredients such as, for example, fillers, sweeteners, etc...
The following orally taken preparations have proved to S° be particularly suitable: S~ca A 462 mg soft gelatin capsule S 20 Composition per capsule: Peanut 103 mg Hydrogenated soybean 15.0 mg Safflower 85 mg (-carotene in oily suspension...... 3.45 mg 25 (0.69 mg of P-carotene) Vitamin 7.5 mg Vitamin 0.780 mg Vitamin 0.863 mg Vitamin 5.0 mg Vitamin 0.150 mg Vitamin C (ascorbic 25.0 mg 70.0 mg In order to have the required doses of vitamins, two 462.mg capsules are adminstered per day.
10 B 463 mg soft gelatin capsule Composition per capsule: Wheatgerm 168 mg Vitamin 15.75 mg /?-carotene in oily suspension 13.8 mg (2.76 mg of P-carotene) Vitamin 0.690mg Vitamin 0.660mg Vitamin 10 mg Vitambin 0.150mg Vitamin C (ascorbic 50 mg Folic 0.230mg Vitamin 1.1 mg Vitamin 7.5 mg Selenium (lOO0mcg/g selenium yeast) 40 mg mcg of selenium) Administration of one 463 mg capsule per day provides the required doses of vitamins.
I 4 1 1 4 #44 4.4 t4 4,44 44 44 4 4 I 6 4 44,4 4 4 4. 4 44 4 4 41 44 4 4 4 4 44 44 4~ 4 444 *0 4 4 4 4 4 44 C Soft gelatin capsule Composition per capsule: oil of blackcurrant seeds Vitamin 20% P,-carotene in oily suspension Vitamin Vitamin Vitamin Vitamin Zinc Selenium Administration of one such capsule per the required doses of vitamins.
200 mg 300 mg 15 mg 15 mg 1 mg 4 mg 0.250 mg 60 mg 20 mg 120 mg day provides 11 D Suspension P-carotene in oily suspension...... 1.25 g (0.25 g of P-carotene) Vitamin B1 0.065 g Vitamin 0.105 g Vitamin B5 0.55 g Vitamin C. 2.5 g Vitamin 1 g Vitamin 0.005 g Oil of blackcurrant seeds sufficient to make 100 ml Administration of 2 ml of the suspension per day provides the required doses of vitamins.
The present invention also relates to a box for S 15 improving the aesthetic appearance of the skin, which consists of two parts, the first part being constituted by the cosmetic composition according to the invention as defined f above and the second part by an orally administered preparation as defined above, each part being provided in quantities allowing a treatment of at least 15 days.
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Claims (8)
- 2. A composition according to claim i, characterized by the fact that it preferably contains the mixture of vita- tiri t I I mins in the following proportions by weight based on the total weight of the composition: Vitamin E between 1.5 and 5 Vitamin A between 0.15 and 0.35 SVitamin B2: between 0.002 and 0.008% Vitamin B5: between 1 and 2 S 20 Vitamin H between 0.015 and 0.03
- 3. A composition according to either of claims 1 and 2 characterized by the fact that it additionally contains vitamin F, vitamin D, vitamin B6 and/or folic acid. St 254. A composition according to claim 3, characterized by the fact that it contains from 0.005 to 0.025% by weight of folic acid, and preferably from 0.0075 to 0.015%. A composition according to any one of the preceding claims, characterized by the fact that is comes in the form of a cream, a milk, a serum or an emulsion.
- 6. A box for improving the aesthetic appearance of the skin, characterized by the fact that it is in the form of a two-part packaging, the first part being constituted by a cosmetic composition according to claims 1 to 5 and the second part by an orally taken multivitamin preparation, each part being provided in quantities allowing a treatment Sof at least 15 days. III I U 1" 13 L Ir 4 44 t4 I 9 9* 4 4 e~ 9 *4U4 9 9 44 4 9* 44 9
- 7. A box according to claim 6, characterized by the fact that the orally taken preparation contains a mixture of vitamins E, A (J-carotene), B2, B5, H, B1 and C.
- 8. A box according to claim 7, characterized by the fact that it contains a mixture of the said vitamins in the following proportions: Vitamin 3.75 to 30 mg Provitamin A 1.2 to 30 mg Vitamin 0.3 to 5 mg 10 Vitamin B5 2.5 to 15 mg Vitamin 0.075 to 0.45mg Vitamin 0.3 to 2 mg Vitamin 20 to 200 mg
- 9. A box according to claims 7 and 8, characterized by the fact that the orally taken preparation additionally con- tains vitamin D and/or vitamin PP and/or vitamin B6 as well as mineral elements and/or oligo-elements.
- 10. A box according to claims 6 to 9, characterized by the fact that the orally taken preparation comes in the form of a capsule or a gelatin capsule. 4,09 S4 4 i ik i Cr~- I* 14
- 11. A composition according to claim 1, or a product according to Claim 6 substantially as hereinbefore described. 1 1 Ir t'U, 4- A t r disclosed herein or referred to or ind in the specification and/or c of this application, individual o lectively, and any and all combinations eqHNt #=WH H 1: MH 1: 101 UA 4: 1U Ne tUt H 1 ell ULJ.CN St I s 9 9 91' 49r #9 9 0 9* 0 00 9 *0 0* S 00 o 0 DATED this TWENTY FOURTH day of FEBRUARY 1989 L'Oreal by DAVIES COLLISON Patent Attorneys for the applicant(s) 0409 0 4999 0
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LU87145 | 1988-02-26 | ||
LU87145A LU87145A1 (en) | 1988-02-26 | 1988-02-26 | METHOD FOR IMPROVING THE AESTHETIC APPEARANCE OF THE SKIN USING POLYVITAMIN MIXTURES |
Publications (2)
Publication Number | Publication Date |
---|---|
AU3075689A AU3075689A (en) | 1989-08-31 |
AU612004B2 true AU612004B2 (en) | 1991-06-27 |
Family
ID=19731029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU30756/89A Ceased AU612004B2 (en) | 1988-02-26 | 1989-02-24 | Cosmetic composition for improving the aesthetic appearance of the skin based on multivitamin mixtures |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP0330583B1 (en) |
JP (1) | JPH01268617A (en) |
AT (2) | ATE136455T1 (en) |
AU (1) | AU612004B2 (en) |
DE (2) | DE68908437T2 (en) |
ES (1) | ES2086617T3 (en) |
LU (1) | LU87145A1 (en) |
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GB9006785D0 (en) * | 1990-03-27 | 1990-05-23 | Leung Lit Hung | Composition and methods for treatment of acne vulgaris and retardation of ageing |
DE4018964C1 (en) * | 1990-06-13 | 1991-07-04 | Gerhard Prof. Dr.Med. 8602 Muehlhausen De Weber | |
SE468541B (en) * | 1990-07-17 | 1993-02-08 | Maja Zeidler | CONCENTRATED MIXTURE CONTAINING VITAMINES FOR ADDITION TO SKIN FOOD |
JPH0491769A (en) * | 1990-08-08 | 1992-03-25 | World Foods Kk | Preparation of beta-carotene beverage |
JP3545429B2 (en) * | 1992-07-13 | 2004-07-21 | 株式会社資生堂 | Retinol stable combination skin external preparation |
FR2694692B1 (en) * | 1992-08-13 | 1994-10-28 | Thorel Jean Noel | Cosmetic preparation for skin nutrition. |
DE4232140C2 (en) * | 1992-09-25 | 1995-12-14 | Medi Concept Unternehmensberat | Care set for the treatment of skin in neurodermatitis |
FR2697750B1 (en) * | 1992-11-06 | 1995-01-20 | Lucien Eustatiu | Cosmetic preparations revitalizing the skin. |
US5520991A (en) * | 1992-11-06 | 1996-05-28 | Eustatiu; Lucien | Cosmetic preparations for revitalizing the skin |
FR2698268B1 (en) * | 1992-11-24 | 1995-01-20 | Oreal | Photoprotective composition administered orally. |
DE4242876C2 (en) * | 1992-12-18 | 1997-11-27 | Beiersdorf Ag | Cosmetic and / or dermatological preparations for the cosmetic and / or dermatological care of the skin and / or the skin appendages |
FR2714595B1 (en) * | 1993-12-30 | 1996-02-02 | Oreal | Water in oil emulsion containing retinol, its use and packaging. |
FR2718353B3 (en) * | 1994-04-11 | 1996-06-28 | Jean Berque | Pharmaceutical compositions based on non-toxic biological products intended for the local protection of the genital and rectal mucosa. |
FR2722094B1 (en) * | 1994-07-05 | 1997-07-11 | Jcb Cosmetiques | ORAL COMPOSITION FOR REACTIVATING THE FLAG TANNING BASED ON A CAROTENOID AND A TOCOPHEROL |
UA10208A (en) * | 1994-08-03 | 1996-12-25 | Жанна Прокопівна Гудзенко | Dermatological cosmetic preparation |
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DE19701651A1 (en) * | 1997-01-18 | 1998-07-23 | Rovi Gmbh Handelsgesellschaft | Aqueous composition with liposomes containing biotin |
IT1306141B1 (en) * | 1999-05-17 | 2001-05-30 | Giampiero Valletta | COMPOSITION FOR THE TREATMENT OF UREMIC ITCHING AND OF DEPRURED FORMS NOT RELATED TO ORGANIC INJURIES. |
GB9918025D0 (en) * | 1999-07-30 | 1999-09-29 | Unilever Plc | Skin care composition |
GB9919079D0 (en) * | 1999-08-12 | 1999-10-13 | Clayton Paul R | Skin care product |
EP1275369A1 (en) * | 2001-07-10 | 2003-01-15 | Goldschmidt AG | Folic acid containing personal care product |
MXPA05008216A (en) * | 2003-01-31 | 2005-10-05 | Procter & Gamble | Means for improving the appearance of mammalian keratinous tissue. |
EP1625844A4 (en) * | 2003-05-16 | 2009-05-13 | Lotus Pharmaceutical Co Ltd | The composition for external use by percutaneous administration |
JP2005041861A (en) * | 2003-07-09 | 2005-02-17 | Takeda Chem Ind Ltd | Inhibitor for reducing water content in horny layer of skin |
FR2886154B1 (en) * | 2005-05-27 | 2010-03-26 | Cothera | COMPOSITION FOR DELAYING THE DEVELOPMENT OF ALZHEIMER'S DISEASE |
CN1911238A (en) * | 2005-08-08 | 2007-02-14 | 美时化学制药股份有限公司 | Composite used for skin, and its application method |
DE102006038758A1 (en) * | 2006-04-25 | 2007-10-31 | Christine Schrammek Kosmetik Gmbh & Co. Kg | Use of a skin cream in combination with a dietary supplement to the cosmetic treatment of a human skin |
FR2996136B1 (en) | 2012-09-28 | 2015-01-02 | Inneov Lab | USE OF AN ASSOCIATION OF AT LEAST ONE POLYUNSATURATED FATTY ACID AND AT LEAST ONE CAROTENOID TO ENHANCE THE QUALITY OF NAILS. |
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-
1988
- 1988-02-26 LU LU87145A patent/LU87145A1/en unknown
-
1989
- 1989-02-23 JP JP1045032A patent/JPH01268617A/en active Pending
- 1989-02-24 AT AT92119446T patent/ATE136455T1/en not_active IP Right Cessation
- 1989-02-24 EP EP89400531A patent/EP0330583B1/en not_active Expired - Lifetime
- 1989-02-24 AU AU30756/89A patent/AU612004B2/en not_active Ceased
- 1989-02-24 DE DE89400531T patent/DE68908437T2/en not_active Expired - Fee Related
- 1989-02-24 AT AT89400531T patent/ATE93135T1/en not_active IP Right Cessation
- 1989-02-24 ES ES92119446T patent/ES2086617T3/en not_active Expired - Lifetime
- 1989-02-24 DE DE68926250T patent/DE68926250T2/en not_active Expired - Fee Related
- 1989-02-24 EP EP92119446A patent/EP0530862B1/en not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6291986A (en) * | 1985-10-07 | 1987-04-09 | Basf Aktiengesellschaft | Vitamin-containing granules and production thereof |
Also Published As
Publication number | Publication date |
---|---|
ATE93135T1 (en) | 1993-09-15 |
DE68926250T2 (en) | 1996-11-21 |
EP0330583B1 (en) | 1993-08-18 |
DE68908437D1 (en) | 1993-09-23 |
DE68908437T2 (en) | 1994-02-03 |
EP0330583A3 (en) | 1991-03-13 |
JPH01268617A (en) | 1989-10-26 |
ES2086617T3 (en) | 1996-07-01 |
EP0530862B1 (en) | 1996-04-10 |
LU87145A1 (en) | 1989-09-20 |
EP0530862A3 (en) | 1993-11-10 |
AU3075689A (en) | 1989-08-31 |
ATE136455T1 (en) | 1996-04-15 |
EP0530862A2 (en) | 1993-03-10 |
DE68926250D1 (en) | 1996-05-15 |
EP0330583A2 (en) | 1989-08-30 |
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