AU6087299A - Method for producing 6,6-dialkoxy-5-hydroxy-3-oxo-hexanoic acid esters - Google Patents

Method for producing 6,6-dialkoxy-5-hydroxy-3-oxo-hexanoic acid esters

Info

Publication number
AU6087299A
AU6087299A AU60872/99A AU6087299A AU6087299A AU 6087299 A AU6087299 A AU 6087299A AU 60872/99 A AU60872/99 A AU 60872/99A AU 6087299 A AU6087299 A AU 6087299A AU 6087299 A AU6087299 A AU 6087299A
Authority
AU
Australia
Prior art keywords
dialkoxy
oxo
hydroxy
producing
acid esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU60872/99A
Inventor
Josef Schroer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of AU6087299A publication Critical patent/AU6087299A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The invention relates to a method for producing 6,6-dialkoxy-5-hydroxy-3-oxo-hexanoic acid esters of general formula (I), wherein the di-anion of an acetoacetic acid alkyl ester is reacted with an aldehyde. The 6,6-dialkoxy-5-hydroxy-3-oxo-hexanoic acid esters of general formula (I) are important synthesis building blocks for producing HMG-CoA-reductase-inhibitors.
AU60872/99A 1998-09-25 1999-09-23 Method for producing 6,6-dialkoxy-5-hydroxy-3-oxo-hexanoic acid esters Abandoned AU6087299A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP98118191 1998-09-25
EP98118191 1998-09-25
US14704199P 1999-08-03 1999-08-03
US60147041 1999-08-03
PCT/EP1999/007100 WO2000018718A1 (en) 1998-09-25 1999-09-23 Method for producing 6,6-dialkoxy-5-hydroxy-3-oxo-hexanoic acid esters

Publications (1)

Publication Number Publication Date
AU6087299A true AU6087299A (en) 2000-04-17

Family

ID=56289947

Family Applications (1)

Application Number Title Priority Date Filing Date
AU60872/99A Abandoned AU6087299A (en) 1998-09-25 1999-09-23 Method for producing 6,6-dialkoxy-5-hydroxy-3-oxo-hexanoic acid esters

Country Status (11)

Country Link
EP (1) EP1115689B1 (en)
JP (1) JP2002525345A (en)
CN (1) CN1209339C (en)
AT (1) ATE259774T1 (en)
AU (1) AU6087299A (en)
CA (1) CA2345134A1 (en)
CZ (1) CZ20011044A3 (en)
HU (1) HUP0103515A3 (en)
PL (1) PL346899A1 (en)
SK (1) SK4202001A3 (en)
WO (1) WO2000018718A1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2670206B1 (en) * 1990-12-11 1993-01-22 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF DERIVATIVES OF 3,5-DIHYDROXY ACID PENTANOUIC.

Also Published As

Publication number Publication date
CN1209339C (en) 2005-07-06
HUP0103515A3 (en) 2003-10-28
SK4202001A3 (en) 2001-12-03
CZ20011044A3 (en) 2001-09-12
CA2345134A1 (en) 2000-04-06
WO2000018718A1 (en) 2000-04-06
EP1115689A1 (en) 2001-07-18
PL346899A1 (en) 2002-03-11
ATE259774T1 (en) 2004-03-15
CN1320112A (en) 2001-10-31
JP2002525345A (en) 2002-08-13
EP1115689B1 (en) 2004-02-18
HUP0103515A2 (en) 2003-08-28

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase