AU6043296A - Chemically modified oligonucleotide for site-directed mutage nesis - Google Patents
Chemically modified oligonucleotide for site-directed mutage nesisInfo
- Publication number
- AU6043296A AU6043296A AU60432/96A AU6043296A AU6043296A AU 6043296 A AU6043296 A AU 6043296A AU 60432/96 A AU60432/96 A AU 60432/96A AU 6043296 A AU6043296 A AU 6043296A AU 6043296 A AU6043296 A AU 6043296A
- Authority
- AU
- Australia
- Prior art keywords
- site
- chemically modified
- modified oligonucleotide
- nesis
- directed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3511—Conjugate intercalating or cleaving agent
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46351995A | 1995-06-06 | 1995-06-06 | |
US463519 | 1995-06-06 | ||
PCT/US1996/008883 WO1996039195A2 (en) | 1995-06-06 | 1996-06-04 | Chemically modified oligonucleotide for site-directed mutagenesis |
Publications (1)
Publication Number | Publication Date |
---|---|
AU6043296A true AU6043296A (en) | 1996-12-24 |
Family
ID=23840376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU60432/96A Abandoned AU6043296A (en) | 1995-06-06 | 1996-06-04 | Chemically modified oligonucleotide for site-directed mutage nesis |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU6043296A (en) |
WO (1) | WO1996039195A2 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6136601A (en) * | 1991-08-21 | 2000-10-24 | Epoch Pharmaceuticals, Inc. | Targeted mutagenesis in living cells using modified oligonucleotides |
US11918695B2 (en) | 2014-05-09 | 2024-03-05 | Yale University | Topical formulation of hyperbranched polymer-coated particles |
PL3140269T3 (en) | 2014-05-09 | 2024-03-11 | Yale University | Hyperbranched polyglycerol-coated particles and methods of making and using thereof |
EP3416976A2 (en) | 2016-02-16 | 2018-12-26 | Yale University | Compositions for enhancing targeted gene editing and methods of use thereof |
US20200308590A1 (en) | 2016-02-16 | 2020-10-01 | Yale University | Compositions and methods for treatment of cystic fibrosis |
WO2018187493A1 (en) | 2017-04-04 | 2018-10-11 | Yale University | Compositions and methods for in utero delivery |
US20210189431A1 (en) | 2018-08-10 | 2021-06-24 | Yale University | Compositions and methods for embryonic gene editing in vitro |
SG11202101984PA (en) | 2018-08-31 | 2021-03-30 | Univ Yale | Compositions and methods for enhancing triplex and nuclease-based gene editing |
WO2020112195A1 (en) | 2018-11-30 | 2020-06-04 | Yale University | Compositions, technologies and methods of using plerixafor to enhance gene editing |
US20220243211A1 (en) | 2019-06-21 | 2022-08-04 | Yale University | Peptide nucleic acid compositions with modified hoogsteen binding segments and methods of use thereof |
WO2020257779A1 (en) | 2019-06-21 | 2020-12-24 | Yale University | Hydroxymethyl-modified gamma-pna compositions and methods of use thereof |
US20220339294A1 (en) | 2019-09-09 | 2022-10-27 | Yale University | Nanoparticles for selective tissue or cellular uptake |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0253193B1 (en) * | 1986-07-08 | 1992-10-28 | Abbott Laboratories | Method for mutagenesis by oligonucleotide-directed repair of a strand break |
JP3398957B2 (en) * | 1991-12-24 | 2003-04-21 | ザ・プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | Mutagenesis of specific sites in DNA |
DE69407590T2 (en) * | 1993-06-25 | 1998-07-23 | Univ Yale New Haven | CHEMICAL-MODIFIED OLIGONUCLEOTIDES FOR SITE-SPECIFIC MUTAGENESIS |
-
1996
- 1996-06-04 WO PCT/US1996/008883 patent/WO1996039195A2/en active Application Filing
- 1996-06-04 AU AU60432/96A patent/AU6043296A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1996039195A3 (en) | 1997-01-30 |
WO1996039195A2 (en) | 1996-12-12 |
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