AU5825598A - Enhanced suppression of hiv-1 by the combination of cytidine nucleoside analogues and ctp synthase inhibitors - Google Patents

Enhanced suppression of hiv-1 by the combination of cytidine nucleoside analogues and ctp synthase inhibitors

Info

Publication number
AU5825598A
AU5825598A AU58255/98A AU5825598A AU5825598A AU 5825598 A AU5825598 A AU 5825598A AU 58255/98 A AU58255/98 A AU 58255/98A AU 5825598 A AU5825598 A AU 5825598A AU 5825598 A AU5825598 A AU 5825598A
Authority
AU
Australia
Prior art keywords
hiv
combination
synthase inhibitors
nucleoside analogues
ctp synthase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU58255/98A
Inventor
Wen-Yi Gao
David G. Johns
Victor Marquez
Hiroaki Mitsuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
National Aeronautics and Space Administration NASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services, National Aeronautics and Space Administration NASA filed Critical US Department of Health and Human Services
Publication of AU5825598A publication Critical patent/AU5825598A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
AU58255/98A 1997-01-21 1998-01-20 Enhanced suppression of hiv-1 by the combination of cytidine nucleoside analogues and ctp synthase inhibitors Abandoned AU5825598A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3391897P 1997-01-21 1997-01-21
US60033918 1997-01-21
PCT/US1998/000784 WO1998031375A1 (en) 1997-01-21 1998-01-20 Enhanced suppression of hiv-1 by the combination of cytidine nucleoside analogues and ctp synthase inhibitors

Publications (1)

Publication Number Publication Date
AU5825598A true AU5825598A (en) 1998-08-07

Family

ID=21873196

Family Applications (1)

Application Number Title Priority Date Filing Date
AU58255/98A Abandoned AU5825598A (en) 1997-01-21 1998-01-20 Enhanced suppression of hiv-1 by the combination of cytidine nucleoside analogues and ctp synthase inhibitors

Country Status (2)

Country Link
AU (1) AU5825598A (en)
WO (1) WO1998031375A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0001531D0 (en) 2000-04-27 2000-04-27 Uminova Center Medication for the treatment of diseases caused by parasitic protozoa
WO2014186435A2 (en) 2013-05-14 2014-11-20 University Of Georgia Research Foundation, Inc. Compositions and methods for reducing neointima formation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3836645A (en) * 1972-06-23 1974-09-17 Icn Pharmaceuticals Anti-viral compositions containing 3-deaza nucleosides
AU7120987A (en) * 1986-02-20 1987-09-09 Sheldon B. Greer Composition for and method of treating aids and certain related diseases
JPH044881A (en) * 1990-04-23 1992-01-09 Takeda Chem Ind Ltd Cytidine analogue resistant gene dna and use thereof

Also Published As

Publication number Publication date
WO1998031375A1 (en) 1998-07-23

Similar Documents

Publication Publication Date Title
GC0000174A (en) Nucleoside analogues suitable for use as anti-viral agents
GB9602028D0 (en) Nucleoside analogues
AU1262001A (en) Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
HUP0201708A3 (en) The use of nucleoside analogues for treating leukemia
AU2001282522A1 (en) Novel nucleoside analogs and oligonucleotide derivatives containing these analogs
PL340109A1 (en) Method of obtaining analogues of nucleosides
ZA9811833B (en) Pharmaceutical compositions of uridine triphosphate.
AU6666598A (en) Antiviral phosphonate prodrugs of nucleosides and nucleoside analogues
HUP0104827A3 (en) Antiviral nucleoside analogues
AU1031799A (en) Sarcodictyin and eleutherobin useful for stabilising microtubules
ZA200104144B (en) Thiourea inhibitors of herpes viruses.
AU5825598A (en) Enhanced suppression of hiv-1 by the combination of cytidine nucleoside analogues and ctp synthase inhibitors
AU2653200A (en) Stereoselective synthesis of nucleoside analogues
AU6209398A (en) Purine diones as phosphodiesterase inhibitors
AU5321398A (en) Stabilized aqueous nucleoside triphosphate solutions
AU2338101A (en) Imidazopyrimidine nucleoside analogues with anti-hiv activity
PL349043A1 (en) Thiourea inhibitors of herpes viruses
PL348177A1 (en) Thiourea inhibitors of herpes viruses
GB9815925D0 (en) HIV Intergrase inhibitors
AU7019200A (en) Nucleoside analogues
EP1406896B8 (en) Stereoselective method for the preparation of nucleoside analogues
GB2309969B (en) Nucleoside analogues
AU1029295A (en) Production of nucleoside analogues
AU6843998A (en) Cyclic adenosine diphosphate ribose analogues
AU8802598A (en) Peptidomimetic derivatives suicidal inhibitors of the hiv proliferation