AU5695173A - p-HYDROXYMETHYLPHENYL-ACETAMIDICEPHALOSPORINS AND INTERMEDIATES - Google Patents

p-HYDROXYMETHYLPHENYL-ACETAMIDICEPHALOSPORINS AND INTERMEDIATES

Info

Publication number
AU5695173A
AU5695173A AU56951/73A AU5695173A AU5695173A AU 5695173 A AU5695173 A AU 5695173A AU 56951/73 A AU56951/73 A AU 56951/73A AU 5695173 A AU5695173 A AU 5695173A AU 5695173 A AU5695173 A AU 5695173A
Authority
AU
Australia
Prior art keywords
acetamidicephalosporins
hydroxymethylphenyl
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU56951/73A
Other versions
AU470357B2 (en
Inventor
LAWRENCE DUNN and JOHN RUSSEL EUGENE HOOVER GEORGE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US262903A external-priority patent/US3867380A/en
Priority claimed from US00289499A external-priority patent/US3855213A/en
Priority claimed from US359566A external-priority patent/US3891634A/en
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of AU5695173A publication Critical patent/AU5695173A/en
Application granted granted Critical
Publication of AU470357B2 publication Critical patent/AU470357B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cephalosporin Compounds (AREA)
AU56951/73A 1972-06-14 1973-06-14 p-HYDROXYMETHYLPHENYL-ACETAMIDICEPHALOSPORINS AND INTERMEDIATES Expired AU470357B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
USUS262903 1972-06-14
US262903A US3867380A (en) 1971-02-18 1972-06-14 3-Heterocyclic thiomethylcephalosporins
US00289499A US3855213A (en) 1971-02-18 1972-09-15 3-heterocyclic thiomethyl-cephalosporins
US359566A US3891634A (en) 1970-12-17 1973-05-11 P-Hydroxymethylphenylacetamidocephalosporins

Publications (2)

Publication Number Publication Date
AU5695173A true AU5695173A (en) 1974-12-19
AU470357B2 AU470357B2 (en) 1976-03-11

Family

ID=27401551

Family Applications (1)

Application Number Title Priority Date Filing Date
AU56951/73A Expired AU470357B2 (en) 1972-06-14 1973-06-14 p-HYDROXYMETHYLPHENYL-ACETAMIDICEPHALOSPORINS AND INTERMEDIATES

Country Status (6)

Country Link
JP (1) JPS4949983A (en)
AU (1) AU470357B2 (en)
CA (1) CA1003405A (en)
DE (1) DE2330296A1 (en)
FR (1) FR2187306B1 (en)
GB (1) GB1427211A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1074784A (en) * 1974-09-06 1980-04-01 Sumitomo Chemical Company N-ACYLAMINO-.alpha.-ARYLACETAMIDO CEPHALOSPORINS
JPH01157988A (en) * 1987-12-12 1989-06-21 Microbial Chem Res Found Oral cephalosporin derivative
GB9325360D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1524225A (en) * 1966-09-14 1968-05-10 Lilly Co Eli Process for the preparation of 7-alpha-aminobenzyl-3-methyl cephalosporin analogs

Also Published As

Publication number Publication date
GB1427211A (en) 1976-03-10
JPS4949983A (en) 1974-05-15
AU470357B2 (en) 1976-03-11
DE2330296A1 (en) 1974-01-03
CA1003405A (en) 1977-01-11
FR2187306B1 (en) 1976-12-31
FR2187306A1 (en) 1974-01-18

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