AU5568694A - Stable oligonucleotides - Google Patents
Stable oligonucleotidesInfo
- Publication number
- AU5568694A AU5568694A AU55686/94A AU5568694A AU5568694A AU 5568694 A AU5568694 A AU 5568694A AU 55686/94 A AU55686/94 A AU 55686/94A AU 5568694 A AU5568694 A AU 5568694A AU 5568694 A AU5568694 A AU 5568694A
- Authority
- AU
- Australia
- Prior art keywords
- stable oligonucleotides
- oligonucleotides
- stable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9224640 | 1992-11-24 | ||
| GB9224640A GB2273932A (en) | 1992-11-24 | 1992-11-24 | Stable oligonucleotides |
| PCT/GB1993/002409 WO1994012633A1 (en) | 1992-11-24 | 1993-11-23 | Stable oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU5568694A true AU5568694A (en) | 1994-06-22 |
Family
ID=10725623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU55686/94A Abandoned AU5568694A (en) | 1992-11-24 | 1993-11-23 | Stable oligonucleotides |
Country Status (4)
| Country | Link |
|---|---|
| AU (1) | AU5568694A (en) |
| GB (1) | GB2273932A (en) |
| MX (1) | MX9307327A (en) |
| WO (1) | WO1994012633A1 (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2703053B1 (en) * | 1993-03-26 | 1995-06-16 | Genset Sa | STAPLE AND SEMI-STAPLE OLIGONUCLEOTIDES, PREPARATION METHOD AND APPLICATIONS. |
| US5700923A (en) * | 1994-09-29 | 1997-12-23 | Hybridon, Inc. | Finderons and methods of their preparation and use |
| US5650502A (en) * | 1994-11-09 | 1997-07-22 | Hybridon, Inc. | Ribozyme analogs having rigid non-nucleotidic linkers |
| US5545729A (en) * | 1994-12-22 | 1996-08-13 | Hybridon, Inc. | Stabilized ribozyme analogs |
| DE19631919C2 (en) * | 1996-08-07 | 1998-07-16 | Deutsches Krebsforsch | Anti-sense RNA with secondary structure |
| EP1783139B8 (en) | 1996-10-01 | 2009-09-23 | Geron Corporation | Human telomerase catalytic subunit |
| US6610539B1 (en) * | 1997-07-10 | 2003-08-26 | Genesense Technologies, Inc. | Antisense oligonucleotide sequences as inhibitors of microorganisms |
| EP1584681A3 (en) * | 1997-07-10 | 2005-11-09 | GeneSense Technologies Inc. | Antisense oligonucleotide sequences as inhibitors of microorganisms |
| DE19826758C1 (en) * | 1998-06-15 | 1999-10-21 | Soft Gene Gmbh | Production of closed, double-stranded DNA molecules for use in gene therapy or genetic vaccination |
| FR2790757B1 (en) | 1999-03-09 | 2003-08-01 | Bioalliance Pharma | OLIGONUCLEOTIDES CONTAINING AN ANTI-SENSE SEQUENCE STABILIZED BY A SECONDARY STRUCTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. |
| CA2387018C (en) | 1999-10-12 | 2008-02-12 | Chemocentryx, Inc. | Chemokine receptor |
| AU2004276684A1 (en) * | 2003-09-30 | 2005-04-07 | Anges Mg, Inc. | Staple type oligonucleotide and drug comprising the same |
| JP5838017B2 (en) | 2003-12-03 | 2015-12-24 | コーダ セラピューティクス， インコーポレイテッド | Antisense compounds targeted against connexins and methods of use thereof |
| EP1838875A4 (en) * | 2004-12-30 | 2010-08-25 | Todd M Hauser | Compositions and methods for modulating gene expression using self-protected oligonucleotides |
| CA2592941A1 (en) | 2005-01-10 | 2006-08-17 | Regents Of The University Of California | Use of inhibitors of soluble epoxide hydrolase to synergize activity of cox and 5-lox inhibitors |
| KR20080031154A (en) | 2005-02-03 | 2008-04-08 | 코다 테라퓨틱스 (엔지) 리미티드 | Anti-connexin compounds and uses thereof |
| US8247384B2 (en) | 2006-11-15 | 2012-08-21 | Coda Therapeutics, Inc. | Methods and compositions for wound healing |
| WO2011005779A2 (en) | 2009-07-07 | 2011-01-13 | University Of Southern California | Biomarkers for the early detection of autoimmune diseases |
| US10383835B2 (en) | 2012-03-14 | 2019-08-20 | The Regents Of The University Of California | Treatment of inflammatory disorders in non-human mammals |
| US10024844B2 (en) | 2012-12-20 | 2018-07-17 | Hospital For Special Surgery | Identification of an inhibitor of iRhom1 or an inhibitor of iRhom2 |
| ES2894333T3 (en) | 2013-09-26 | 2022-02-14 | Beth Israel Deaconess Medical Ct Inc | SGK1 inhibitors in the treatment of Long QT syndrome |
| CN114010788A (en) | 2014-08-22 | 2022-02-08 | 奥克兰联合服务有限公司 | Channel modulators |
| CN111201247A (en) | 2017-04-28 | 2020-05-26 | 奥克兰联合服务有限公司 | Therapeutic methods and novel constructs |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0204401A1 (en) * | 1985-04-09 | 1986-12-10 | Biogen, Inc. | Method of improving the yield of polypeptides produced in a host cell by stabilizing mRNA |
| WO1990015814A1 (en) * | 1989-06-20 | 1990-12-27 | Meiogenics, Inc. | Nuclease resistant, single-stranded, non-naturally occurring nucleic acid molecules |
| NO904633L (en) * | 1989-11-09 | 1991-05-10 | Molecular Diagnostics Inc | AMPLIFICATION OF NUCLEIC ACIDS BY TRANSCRIPABLE HAIRNEL PROBE. |
| HUT69956A (en) * | 1990-08-14 | 1995-09-28 | Isis Pharmaceuticals Inc | Methode for inhibition of influenza virus by antiseuse oligonucleotides |
| FR2675803B1 (en) * | 1991-04-25 | 1996-09-06 | Genset Sa | CLOSED, ANTISENSE AND SENSE OLIGONUCLEOTIDES AND THEIR APPLICATIONS. |
| CA2119927A1 (en) * | 1991-09-27 | 1993-04-01 | Michael Y.-X. Ma | Duplex-forming polynucleotide conjugates |
-
1992
- 1992-11-24 GB GB9224640A patent/GB2273932A/en not_active Withdrawn
-
1993
- 1993-11-23 WO PCT/GB1993/002409 patent/WO1994012633A1/en active Application Filing
- 1993-11-23 AU AU55686/94A patent/AU5568694A/en not_active Abandoned
- 1993-11-23 MX MX9307327A patent/MX9307327A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9224640D0 (en) | 1993-01-13 |
| GB2273932A (en) | 1994-07-06 |
| MX9307327A (en) | 1994-06-30 |
| WO1994012633A1 (en) | 1994-06-09 |
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