AU543383B2 - Poly-glycidyl-substituted n-hetero-cycles as cytostatic agents - Google Patents

Poly-glycidyl-substituted n-hetero-cycles as cytostatic agents

Info

Publication number
AU543383B2
AU543383B2 AU66761/81A AU6676181A AU543383B2 AU 543383 B2 AU543383 B2 AU 543383B2 AU 66761/81 A AU66761/81 A AU 66761/81A AU 6676181 A AU6676181 A AU 6676181A AU 543383 B2 AU543383 B2 AU 543383B2
Authority
AU
Australia
Prior art keywords
ring
substituted
following formula
heterocyclic
formula see
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU66761/81A
Other versions
AU6676181A (en
Inventor
Manfred Budnowski
Herbert Fischer
Brigitte Hase
Christian Hase
Hinrich Moller
Hans-Christoph Wilk
Ulrich Zeidler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henkel AG and Co KGaA
Original Assignee
Henkel AG and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19803003404 external-priority patent/DE3003404A1/en
Priority claimed from DE19803003357 external-priority patent/DE3003357A1/en
Priority claimed from DE19803003356 external-priority patent/DE3003356A1/en
Priority claimed from AT564480A external-priority patent/AT370729B/en
Application filed by Henkel AG and Co KGaA filed Critical Henkel AG and Co KGaA
Publication of AU6676181A publication Critical patent/AU6676181A/en
Application granted granted Critical
Publication of AU543383B2 publication Critical patent/AU543383B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

For the contracting States : BE CH DE FR GB IT LI NL SE 1. Cytostatic medicinal preparations based on polyglycidyl-substituted N-heterocyclic organic ring compounds, characterized in that they contain in one heterocyclic ring or in two interconnected heterocyclic rings, which either have one or two ring members in common or are attached to one another by a bridge member, at least two ring segments corresponding to the following formula see diagramm : EP0033503,P26,F1 or at least one ring segment corresponding to the following formula see diagramm : EP0033503,P26,F2 in which the glycidyl residue corresponds to the following formula see diagramm : EP0033503,P26,F3 in which R is hydrogen or the methyl group, and in that, providing these ring segments are not themselves closed to form the ring, they further contain carbon and, optionally, nitrogen as ring-closing elements and in that they may contain halogens or unsubstituted hydrocarbon radicals containing no more than 8 C-atoms as further substituents on the heterocyclic rings, isocyanurates, urazoles and hydantoins being excluded as heterocycles and the polyglycidyl-substituted N-heterocycles present therein not exceeding a molecular weight of 1000. For the contracting State : AT 1. A process for the production of cytostatic medicinal preparation based on polyglicidyl-substituted N-heterocyclic organic ring compounds, characterized in that the polyglicidyl-substituted N-heterocyclic organic ring compounds contain in one heterocyclic ring or in two interconnected heterocyclic rings, which either have one or two ring members in common or are attached to one another by a bridge member, at least two ring segments corresponding to the following formula see diagramm : EP0033503,P29,F1 or at least one ring segment corresponding to the following formula see diagramm : EP0033503,P29,F2 in which the glycidyl residue corresponds to the following formula see diagramm : EP0033503,P29,F3 in which R is hydrogen or the methyl group, and in that, providing these ring segments are not themselves closed to form the ring, they further contain carbon and, optionally, nitrogen as ring-closing elements and in that they may contain halogens or unsubstituted hydrocarbon radicals containing no more than 8 C-atoms as further substituents on the heterocyclic rings, isocyanurates, urazoles and hydantoins being excluded as heterocycles and the polyglycidyl-substituted N-heterocycles present therein not exceeding a molecular weight of 1000.
AU66761/81A 1980-01-31 1981-01-30 Poly-glycidyl-substituted n-hetero-cycles as cytostatic agents Ceased AU543383B2 (en)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
DE19803003404 DE3003404A1 (en) 1980-01-31 1980-01-31 Cytostatic agents contg. di:glycidyl bi:cyclic cpds. - e.g. N,N'-di:glycidyl-benzimidazolone
DE19803003357 DE3003357A1 (en) 1980-01-31 1980-01-31 Cytostatic agents contg. di:glycidyl-hydantoin derivs. - e.g. N,N'-di:glycidyl-furfurylidene-hydantoin or N,N'-di:glycidyl-5,5-di:methyl-hydantoin
DE3003404 1980-01-31
DE3003357 1980-01-31
DE19803003356 DE3003356A1 (en) 1980-01-31 1980-01-31 Cytostatic agents of di-, tri- or tetra-glycidyl-glycoluril derivs. - e.g. di:glycidyl-butyl-glycoluril or di:glycidyl-di:methyl-glycoluril
DE3303356 1980-01-31
AT133080 1980-03-10
AT1330/80 1980-03-10
AT133180 1980-03-10
AT1331/80 1980-03-10
AT136580 1980-03-12
AT1365/80 1980-03-12
AT1649/80 1980-03-27
AT164980 1980-03-27
AT564480A AT370729B (en) 1980-11-17 1980-11-17 METHOD FOR PRODUCING NEW DIGLYCIDYLTRIAZINE COMPOUNDS
AT5644/80 1980-11-17

Publications (2)

Publication Number Publication Date
AU6676181A AU6676181A (en) 1981-08-06
AU543383B2 true AU543383B2 (en) 1985-04-18

Family

ID=27569969

Family Applications (1)

Application Number Title Priority Date Filing Date
AU66761/81A Ceased AU543383B2 (en) 1980-01-31 1981-01-30 Poly-glycidyl-substituted n-hetero-cycles as cytostatic agents

Country Status (5)

Country Link
EP (1) EP0033503B1 (en)
AT (1) ATE22080T1 (en)
AU (1) AU543383B2 (en)
DE (1) DE3175281D1 (en)
IL (1) IL62021A0 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3102373A1 (en) * 1981-01-24 1982-08-26 Henkel KGaA, 4000 Düsseldorf "NEW N-SUBSTITUTED POLYGLYCIDYL-URAZOLE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS
DE3131365A1 (en) * 1981-08-07 1983-02-24 Henkel KGaA, 4000 Düsseldorf NEW DIGLYCIDYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN PHARMACEUTICAL PREPARATIONS WITH CYTOSTATIC EFFECTIVENESS
DE3131396A1 (en) * 1981-08-07 1983-03-24 Henkel KGaA, 4000 Düsseldorf "NEW DIGLYCIDYL-PTERIDINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS WITH A CYTOSTATIC EFFECT"
DE3133077A1 (en) * 1981-08-21 1983-03-10 Henkel KGaA, 4000 Düsseldorf NEW 1,3,2-OXAZAPHOSPHORINE COMPOUNDS CONTAINING NEW CYTOSTATICALLY EFFECTIVE EPOXY GROUPS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN PHARMACEUTICAL PREPARATIONS
DE3330640A1 (en) * 1983-08-25 1985-03-14 Henkel KGaA, 4000 Düsseldorf METHOD FOR ADDING ACIDS TO GLYCIDYL COMPOUNDS
WO2016139989A1 (en) 2015-03-04 2016-09-09 エア・ウォーター株式会社 Thermal-expansion adjusting agent, usage as thermal-expansion adjusting agent, thermosetting resin composition, insulating material, sealant, and conductive paste containing said thermosetting resin composition, hardened material obtained by hardening said thermosetting resin composition, substrate material having said thermosetting resin composition, prepreg in which base material thereof is impregnated with said thermosetting resin composition, member in which said thermosetting resin composition of said prepreg is hardened, thermal-expansion-rate adjusting method, and member manufactured by using said adjusting method
RU2769828C1 (en) * 2021-12-28 2022-04-06 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Uracil derivatives with antiviral activity against sars-cov-2

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH471811A (en) * 1966-06-23 1969-04-30 Ciba Geigy Process for the preparation of water-soluble N, N'-diglycidyl compounds
DE2907349C2 (en) * 1979-02-24 1982-09-16 Henkel KGaA, 4000 Düsseldorf Medicines with cytostatic activity

Also Published As

Publication number Publication date
IL62021A0 (en) 1981-02-27
AU6676181A (en) 1981-08-06
DE3175281D1 (en) 1986-10-16
ATE22080T1 (en) 1986-09-15
EP0033503A2 (en) 1981-08-12
EP0033503A3 (en) 1982-01-13
EP0033503B1 (en) 1986-09-10

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