AU5394001A - The use of anti-TNF antibodies as drugs for the treatment of disorders with an elevated serum level of interleukin-6 - Google Patents
The use of anti-TNF antibodies as drugs for the treatment of disorders with an elevated serum level of interleukin-6 Download PDFInfo
- Publication number
- AU5394001A AU5394001A AU53940/01A AU5394001A AU5394001A AU 5394001 A AU5394001 A AU 5394001A AU 53940/01 A AU53940/01 A AU 53940/01A AU 5394001 A AU5394001 A AU 5394001A AU 5394001 A AU5394001 A AU 5394001A
- Authority
- AU
- Australia
- Prior art keywords
- tnf
- interleukin
- treatment
- patients
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 210000002966 serum Anatomy 0.000 title claims description 19
- 102000004889 Interleukin-6 Human genes 0.000 title claims description 11
- 108090001005 Interleukin-6 Proteins 0.000 title claims description 11
- 229940100601 interleukin-6 Drugs 0.000 title claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 8
- 208000035475 disorder Diseases 0.000 title description 8
- 229940079593 drug Drugs 0.000 title description 5
- 239000003814 drug Substances 0.000 title description 5
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 31
- 102000003390 tumor necrosis factor Human genes 0.000 claims description 30
- 206010040047 Sepsis Diseases 0.000 claims description 10
- 239000005557 antagonist Substances 0.000 claims description 10
- 208000013223 septicemia Diseases 0.000 claims description 10
- 239000012634 fragment Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims description 5
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims description 5
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims 1
- 235000009685 Crataegus X maligna Nutrition 0.000 claims 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims 1
- 235000009486 Crataegus bullatus Nutrition 0.000 claims 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims 1
- 235000009682 Crataegus limnophila Nutrition 0.000 claims 1
- 235000004423 Crataegus monogyna Nutrition 0.000 claims 1
- 240000000171 Crataegus monogyna Species 0.000 claims 1
- 235000002313 Crataegus paludosa Nutrition 0.000 claims 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims 1
- 239000013543 active substance Substances 0.000 description 8
- 230000037396 body weight Effects 0.000 description 7
- 239000000902 placebo Substances 0.000 description 7
- 229940068196 placebo Drugs 0.000 description 7
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 6
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 206010040070 Septic Shock Diseases 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000036303 septic shock Effects 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 description 1
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 108010074051 C-Reactive Protein Proteins 0.000 description 1
- 102100032752 C-reactive protein Human genes 0.000 description 1
- 241000557626 Corvus corax Species 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 229930105110 Cyclosporin A Natural products 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 102000003814 Interleukin-10 Human genes 0.000 description 1
- 108090000174 Interleukin-10 Proteins 0.000 description 1
- 102000004388 Interleukin-4 Human genes 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 101150033527 TNF gene Proteins 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 102100040247 Tumor necrosis factor Human genes 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 102000023732 binding proteins Human genes 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229940124446 critical care medicine Drugs 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 239000003145 cytotoxic factor Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
- 229960002986 dinoprostone Drugs 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 229940076144 interleukin-10 Drugs 0.000 description 1
- 229940028885 interleukin-4 Drugs 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007119 pathological manifestation Effects 0.000 description 1
- 230000035778 pathophysiological process Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000011301 standard therapy Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 229960003433 thalidomide Drugs 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 230000006433 tumor necrosis factor production Effects 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
P/00/011 28/5/91 Regulation 3.2(2)
AUSTRALIA
Patents Act 1990
ORIGINAL
COMPLETE SPECIFICATION STANDARD PATENT Application Number: Lodged: Invention Title: THE USE OF ANTI-TNF ANTIBODIES AS DRUGS FOR THE TREATMENT OF DISORDERS WITH AN ELEVATED SERUM LEVEL OF INTERLEUKIN-6 :..00 00.0* '0.0 0.
0 The following statement is a full description of this invention, including the best method of performing it known to us The use of anti-TNF antibodies as drugs for the treatment of disorders with an elevated serum level of interleukin-6 The present invention relates to the use of anti-TNF antibodies in the treatment of disorders with an elevated serum level of interleukin-6.
It is known that the term tumor necrosis factor (TNF) embraces two cytotoxic factors (TNF-a and TNF-) which are mostly produced by activated lymphocytes and monocytes.
EP 260 610 describes, for example, anti-TNF antibodies which are said to be utilizable for disorders associated with an increased level of TNF in the blood, such as septic shock, transplant rejection, allergies, autoimmune diseases, shock lung, coagulation disturbances or inflammatory bone diseases, to inactivate
TNF.
Examples of disorders characterized by elevated serum levels of interleukin-6 in patients are the sequelae of transplantations, autoimmune diseases and, in particular, certain types of septicemia.
Septicemia is defined in medical textbooks as a collective clinical term for conditions in which bacterial pathogens, starting from a focus, enter the blood stream to induce a wide range of subjective and objective pathological manifestations. It is furthermore found that the clinical picture may vary widely 30 depending on the type of pathogen, the reactivity of the body, the primary focus and the changes in organ involvement (Sturm et al. "Grundbegriffe der Inneren Medizin", 13th edition, page 570, Gustav Fischer Verlag, Stuttgart, 1984).
35 A number of cytokines have been suggested to be involved in the complex pathophysiological process of septicemia. TNF in particular is ascribed with an important role in septic shock on the basis of data from animal experiments (Beutler et al., Science .229 (1985) 869-871).
This has eventually led to clinical studies of the treatment of septicemic patients with anti-TNF antibodies.
In a recently published multicenter phase II study on the treatment of severe septicemia with a murine monoclonal anti-TNF antibody, however, it was found that the overall population patients) did not profit in terms of survival rate from the treatment with the antibody. Only the patients with elevated circulating TNF concentrations appeared to profit, in terms of probability of survival, from high-dose anti-TNF antibody administration J. Fisher et al., Critical Care Medicine, vol.
21, No. 3, pages 318-327). Furthermore, reference is made in this study to a correlation of the plasma levels of TNF and 11-6.
The part played by the cytokine interleukin-6 (11-6) in septicemia is unclear and contradictory. Elevated serum levels of 11-6 have been found in some septicemic patients (Hack et al., Blood 74 (1989) 1704-1710).
Waage describes a correlation between the concentrations of the cytokines 11-6 and 11-8 with the severity of the shock, although they had no effect, either alone or in combination with TNF, on the development of a shock syndrome in terms of mortality (Waage in "Tumor Necrosis Factors", ed. B. Beutler, Raven Press, New York, 1992, pages 275-283).
Some scientists have ascribed a beneficial role to 11-6 in septic shock because 11-6 inhibits, in the form of negative feedback control, the LPS-induced TNF production (Libert et al. in "Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance", ed. W. Fiers, Karger, Basel, 1993, pages 126-131).
We have now found, surprisingly, that TNF antagonists can be used particularly successfully as drugs for the treatment of disorders characterized by elevated serum levels of interleukin-6.
30 The treatment of septicemia with TNF antagonists is particularly successful according to this invention, for example measured by a distinct reduction in mortality, when the septicemic patients who are treated have 11-6 levels of 500 pg/ml or more at the start of treatment. Patients who have 11-6 serum levels above 1000 pg/ml 35 profit particularly well from the treatment according to the invention.
Elevated serum levels of 11-6 mean levels which are elevated at least ten-fold compared with physiological serum levels in 40 healthy subjects.
Serum concentrations of 11-6 up to 20,000 times the levels in healthy subjects have been found in septicemic patients.
*e* go The "normal" 11-6 serum levels are usually below the detection limit, which may vary slightly depending on the assay system used. Their maximum is, however, 20 pg/ml.
The serum concentrations of 11-6 can be determined by conventional detection methods such as RIA or ELISA. An example of a very suitable detection system is the I1-6-EASIA supplied by Medgenix.
The 11-6 concentration can also be determined by an activity assay in which, for example, C-reactive protein is assayed.
Suitable TNF antagonists are anti-TNF antibodies, TNF receptors and soluble fragments thereof, TNF binding proteins or those TNF derivatives which still bind to TNF receptors but have no TNF activity. TNF antagonists of these types have the characteristic that they trap TNF which has been formed and do not allow it to reach the TNF receptor or that they compete with TNF for the receptor.
However, TNF antagonists which prevent the formation or release of TNF are also suitable for the use according to the invention.
Such substances inhibit for example TNF gene expression or release of TNF from precursor forms.
Such TNF-antagonistic activities have been described for example for xanthine derivatives, glucocorticoids, prostaglandin E2, thalidomide, interleukin-4, interleukin-10, granulocyte-stimulating factor (G-CSF), cyclosporin and a-antitrypsin. Hence com- 30 pounds of these types are also suitable as TNF antagonists. ic Anti-TNF antibodies are particularly preferred for the use according to the invention.
35 The anti-TNF antibodies suitable for the use according to the in- .'vention are known (EP 260 610, EP 351 789, EP 218 868). Both polyclonal and monoclonal antibodies can be used. Furthermore, TNF-binding antibody fragments such as Fab or F(ab')z fragments or 0 single-chain Fv fragments are also suitable.
o* Furthermore, humanized or human anti-TNF antibodies or their TNFbinding fragments are also very suitable because these molecules ought not to cause any anti-mouse antigenicity in human patients.
00 4 It is also possible to use mixtures of various anti-TNF antibodies or of anti-TNF antibodies and TNF receptor fragments as active substance.
The present invention includes pharmaceutical compositions which, non-toxic, inert, pharmaceutically suitable vehicles, contain the anti-TNF antibodies, and processes for the production of these compositions.
The anti-TNF antibodies are formulated in the conventional way for biotechnologically produced active substances, as a rule as liquid formulation or lyophilisate (see, for example, Hagers Handbuch der pharmazeutischen Praxis, vol. 2, 5th edition, 1991, p. 720, ISBN 3-540-52459-2). The abovementioned pharmaceutical compositions are produced in a conventional way by conventional methods, eg. by mixing the active substance or substances with the vehicle or vehicles.
1In general, it has proven advantageous to administer the active substance or substances which are suitable for the use according to the invention in total amounts of about 0.1 to about 1000, preferably 0.1 to 10, mg/kg of body weight every 24 hours, where appropriate in the form of several individual doses or as continuous infusion and, where appropriate, over a therapy period of several days to achieve the desired results. Administration can take place as brief intravenous infusion of the single doses or as continuous long-term infusion of the daily dose over 24 hours.
A single dose preferably contains the active substance or substances in amounts of about 0.1 to about 10 mg/kg of body weight.
However, it may be necessary to deviate from the stated dosages, 25 specifically depending on the age and size of the patient to be treated and on the nature and severity of the fundamental disorder, the type of composition and of administration of the drug, and the period or interval over which administration takes place. The invention is illustrated further in the following Example.
Example Treatment of septicemic patients with a murine anti-TNF antibody fragment as disclosed in EP 260 610.
35 A total of 122 patients with severe septicemia were treated in a multicenter clinical study with anti-TNF antibody fragment in various dosages or with placebo.
The four therapeutic methods investigated differed only in the level of the single dose of the anti-TNF antibody fragment. This was either 0.1 mg/kg of body weight, 0.3 mg/kg of body weight or mg/kg of body weight. The patients in the fourth group received a "sham therapy" (placebo) for comparison. The patients were assigned at random to one of the four therapeutic regimens with anti-TNF antibody fragment. The described therapy, which was given in addition to the standard therapy of septicemic patients, was administered as brief infusion a total of nine times (9 x) at intervals of 8 hours (ie. for three days) after diagnosis compliance with criteria for inclusion in the study). A total of 122 patients was recruited for the study, with 34 patients being assigned to the 0.1 mg/kg dose group, 30 patients to the 0.3 mg/ kg dose group, 29 patients to the 1.0 mg/kg dose group and 29 patients to the placebo group.
It was possible to measure 11-6 serum concentrations before the start of therapy in 119 of the 122 patients. The serum levels of 11-6 were 1000 pg/ml in 36 patients and 1000 pg/ml in 83 patients.
Fig. 1A shows the mortality in the population with 11-6 1000 pg/ml in the various treatment groups (placebo, 0.1, 0.3 and mg of antibody per kg of body weight).
Fig. 1B shows the mortality in the population with 11-6 1000 pg/ml in the various treatment groups (placebo, 0.1, 0.3 and 1.0 mg of antibody per kg of body weight).
30 In the patients with 11-6 1000 pg/ml there was a dose-dependent reduction in the mortality on treatment with anti-TNF antibody i* fragment from 80.0% placebo group) to 36.4% (1.0 mg/kg antibody) (Fig. 1A).
35 In the patients with 11-6 1000 pg/ml, the mortality was not reduced by treatment with anti-TNF antibody fragment, on the contrary it was slightly increased (30.4% in the placebo group compared with 38.9% in the group with 1.0 mg/kg antibody) (Fig. 1B).
The result of this clinical study clearly proves that treatment of severe septicemia with anti-TNF antibodies is successful only when the treated septicemic patients have a serum level of 11-6 1000 pg/ml; treatment of patients with serum levels of 11-6 1000 pg/ml is unsuccessful and sometimes even contraindicated.
Claims (4)
1. 6 THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS: 1. A method of treating a patient with septicemia wherein said patient has serum levels of interleukin-6 (IL-6) above 1,000 pg/ml comprising: selecting a septicemia patient having serum levels of interleukin-6 (IL-6) above 1,000 pg/ml, and administering a therapeutically effective amount of a tumor necrosis factor (TNF) antagonist to said patient.
2. The method of claim 1, wherein said TNF antagonist is a monoclonal anti- TNF antibody.
3. The method of claim 2, wherein said TNF antagonist is a human monoclonal anti-TNF antibody.
4. The method of claim 3, wherein said TNF antagonist is a TNF receptor or soluble fragment thereof. DATED this 20th day of June 2001 KNOLL AKTIENGESELLSCHAFT WATERMARK PATENT TRADEMARK ATTORNEYS 290 BURWOOD ROAD HAWTHORN VICTORIA 3122 AUSTRALIA LCG:AMT:VRH P2014AU01.DOC
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU53940/01A AU5394001A (en) | 1994-02-07 | 2001-06-20 | The use of anti-TNF antibodies as drugs for the treatment of disorders with an elevated serum level of interleukin-6 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4403669 | 1994-02-07 | ||
DE4409513 | 1994-03-19 | ||
AU53940/01A AU5394001A (en) | 1994-02-07 | 2001-06-20 | The use of anti-TNF antibodies as drugs for the treatment of disorders with an elevated serum level of interleukin-6 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU15495/99A Division AU1549599A (en) | 1994-02-07 | 1999-02-08 | The use of anti-TNF antibodies as drugs for the treatment of disorders with an elevated serum level of the interleukin-6 |
Publications (1)
Publication Number | Publication Date |
---|---|
AU5394001A true AU5394001A (en) | 2001-08-16 |
Family
ID=3739925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU53940/01A Abandoned AU5394001A (en) | 1994-02-07 | 2001-06-20 | The use of anti-TNF antibodies as drugs for the treatment of disorders with an elevated serum level of interleukin-6 |
Country Status (1)
Country | Link |
---|---|
AU (1) | AU5394001A (en) |
-
2001
- 2001-06-20 AU AU53940/01A patent/AU5394001A/en not_active Abandoned
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6235281B1 (en) | Use of anti-TNF antibodies as drugs for the treatment of disorders with an elevated serum level of interleukin-6 | |
US20030012786A1 (en) | Use of anti-TNF antibodies as drugs in treating septic disorders of anemic patients | |
US20030161828A1 (en) | Use of TNF antagonists as drugs for the treatment of patients with an inflammatory reaction and without suffering from total organ failure | |
US5741488A (en) | Treatment of rheumatoid arthritis with anti-CD4 antibodies in conjunction with anti-TNF antibodies | |
EP0966300B1 (en) | Treatment of rheumatoid arthritis with antibody anti ifn gamma | |
US8349323B2 (en) | Cytokine antagonists for neurological and neuropsychiatric disorders | |
RU2607022C2 (en) | Methods and compositions for treating lupus | |
Gisondi et al. | Targeting tumor necrosis factor-α in the therapy of psoriasis | |
KR20190117579A (en) | Treatment of purulent hanitis | |
Ogushi et al. | Autoantibodies to IL-1 alpha in sera from rapidly progressive idiopathic pulmonary fibrosis | |
US20060051381A1 (en) | Cytokine antagonists for neurological and neuropsychiatric disorders | |
AU756167B2 (en) | Application of TNF antagonists as medicaments for treating septic diseases | |
AU5394001A (en) | The use of anti-TNF antibodies as drugs for the treatment of disorders with an elevated serum level of interleukin-6 | |
KR100414505B1 (en) | Use of anti-TNF antibodies as a drug for the treatment of diseases with high serum levels of interleukin-6 | |
AU1549599A (en) | The use of anti-TNF antibodies as drugs for the treatment of disorders with an elevated serum level of the interleukin-6 | |
Grau et al. | Prevention of human TNF-induced cutaneous Shwartzmann reaction and acute mortality in mice treated with anti-human TNF monoclonal antibodies. | |
MXPA00003355A (en) | Application of tnf antagonists as medicaments for treating septic diseases | |
CZ20001407A3 (en) | Use of TNF antagonists for preparing drugs intended for treating septic disorders | |
JPH07258112A (en) | Chemical to treat disease that shows interleukin-6 serum concentration ascending symptom |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTORS TO INCLUDE: JURGEN EISELSTEIN |
|
MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |