AU5071002A - Low adenosine oligonucleotide, composition, kit & methods for obtaining oligonucleotide & for treatment of airway disease(s) - Google Patents

Description

AUSTRALIA

Patents Act 1990 COMPLETE SPECIFICATION STANDARD PATENT Applicant(s): EAST CAROLINA UNIVERSITY Invention Title: LOW ADENOSINE OLIGONUCLEOTIDE, COMPOSITION, KIT METHODS FOR OBTAINING OLIGONUCLEOTIDE FOR TREATMENT OF AIRWAY DISEASE(S) The following statement is a full description of this invention, including the best method of performing it known to me/us: LOW ADENOSINE ANTI-SENSE OLIGONUCLEOTIDE, COMPOSITIONS, KIT METHOD FOR TREATMENT OF AIRWAY DISORDERS ASSOCIATED WITH BRONCHOCONSTRICTION, LUNG INFLAMMATION, ALLERGY(IES) SURFACTANT DEPLETION BACKGROUND OF THE INVENTION The entire disclosure in the complete specification of our Australian Patent Application No. 71749/00 is by this cross-reference incorporated into the present specification.

Field of the Invention This patent relates to a composition comprising oligonucleotides (oligos) that are anti-sense to adenosine receptors, and contain low amounts of or no adenosine These agents are suitable for the treatment, among others, of pulmonary diseases associated with inflammation, impaired airways, including lung disease and diseases whose secondary effects afflict the lungs of a subject. Examples of these diseases are allergies, asthma, impeded respiration, allergic rhynitis, pain, cystic fibrosis, and cancers such as leukemias, e.g. colon cancer, and the like. The present agent may be administered prophylactically or therapeutically in conjunction with other therapies, or may be utilized as a substitute for therapies that have significant, negative side effects.

Background of the Invention Respiratory ailments, associated with a variety of diseases and conditions, are extremely common in the general population, and more so in certain ethnic groups, such as African Americans. In some cases they are accompanied by inflammation, which aggravates the condition of the lungs. Asthma, for example, is one of the most common diseases in industrialized countries. In the United States it accounts for about 1% of all health care costs. An alarming increase in both the prevalence and mortality of asthma over the past decade has been reported, and asthma is predicted to be the preeminent occupational lung disease in the next decade. While the increasing mortality of asthma in industrialized countries could be attributable to the depletion reliance la upon beta agonists in the treatment of this disease, the underlying causes of asthma remain poorly understood.

Adenosine may constitute an important mediator in the lung for various diseases, including bronchial asthma. Its potential role was suggested by the finding that asthmatics respond favorably to aerosolized adenosine with marked bronchoconstriction whereas normal individuals do not. An asthmatic rabbit animal model, the dust mite allergic rabbit model for human asthma, responded in a similar fashion to aerosolized adenosine with marked bronchoconstriction whereas non-asthmatic rabbits showed no response. More recent work with this animal model suggested that adenosine-induced bronchoconstriction and bronchial hyperresponsiveness in asthma may be mediated primarily through the stimulation of adenosine receptors. Adenosine has also been shown to cause adverse effects, including death, when administered therapeutically for other diseases and conditions in subjects with previously undiagnosed hyper reactive airways.

A handful of medicaments have been available for the treatment of respiratory diseases and conditions, although in general they all have limitations.

Theophylline, an important drug in the treatment of asthma, is a known adenosine receptor antagonist which was reported to eliminate adenosine-mediated bronchoconstriction in asthmatic rabbits. A selective adenosine Ai receptor antagonist, 8-cyclopentyl-l, 3dipropylxanthine (DPCPX) was also reported to inhibit adenosine-mediated bronchoconstriction and bronchial hyperresponsiveness in allergic rabbits. The therapeutic and preventative applications of currently available adenosine Ai receptor-specific antagonists are, nevertheless, limited by their toxicity. Theophylline, for example, has been widely used in the treatment of asthma, but is associated with frequent, significant toxicity resulting from its narrow therapeutic dose range. DPCPX is far too toxic to be useful clinically.

The fact that, despite decades of extensive research, no specific adenosine receptor antagonist is available for clinical use attests to the general toxicity of these agents. Anti-sense oligonucleotides have received considerable theoretical consideration as potential useful pharmacological agents in human disease. Their practical application in actual models of human disease, however, has been somewhat elusive. One important impediment to their effective application has been a difficulty in finding an appropriate route of administration to deliver them to their site of action.

Many in vivo experiments were conducted by administering anti-sense oligonucleotides directly to specific regions of the brain. These applications, however, necessarily have limited clinical utility due to their invasive nature. Although anti-sense oligonucleotides have received considerable theoretical consideration for their potential use as pharmacological agents in human disease, finding practical and effective applications for these agents in actual models of human disease, however, have been few and far between, particularly because they had to be administered in large doses. Another important consideration in the pharmacologic application of these molecules is their route of administration. Many in vivo applications have involved the direct administration of anti-sense oligonucleotides to limited regions of the brain. Such applications, however, have limited clinical utility due to their invasive nature. The systemic administration of anti-sense oligonucleotides as pharmacological agents has been found to have also significant problems, not the least of which being an inherent difficulty in targeting disease-involved tissues. That is, the necessary dilution of the antisense oligonucleotide in the circulatory system makes extremely difficult to attain a therapeutic dose at the target tissue by intravenous or oral administration. The bioavailability of orally administered anti-sense oligonucleotides is very low, of the order of less than about Anti-sense oligonucleotides have been used in therapy by many, including the present inventor, who in his previous work successfully treated various diseases and conditions by direct administration of these agents to the lung. In many instances, other workers have had to face the difficulties associated with the delivery of DNA molecules to a desired target. Thus, the route of administration may be of extreme importance for treating generalized diseases and conditions as well as those which are localized. In contrast, up to the present time, the delivery of anti-sense agents to the lung has been relatively undeveloped. As described by the present inventor in more detail below, the lung is an excellent target for the direct administration of anti-sense oligonucleotides and provides a non-invasive and a tissue-specific route.

Clearly, there exist presently no effective therapies for treating these ailments, or at least no therapies which are effective and devoid of significant detrimental side effects. Accordingly, there is still a need for an agent for the treatment of adenosine mediated ailments afflicting the pulmonary and respiratory ailments affecting the lung airways, including respiratory problems, bronchoconstriction, inflammation, allergy(ies), depletion or hyposecretion of surfactant, etc., which is highly effective and sufficiently selective to avoid detrimental side effects produced by other therapies. In addition, there is a definite need for making available a delivery method that will require low amounts of therapeutic agents and will be effective for the rapid and targeted access of tissue genes of mRNAs and the reversal of untoward effects afflicting a subject.

SUMMARY OF THE INVENTION The present invention generally relates to a pharmaceutical or veterinary composition, comprising an anti-sense oligonucleotide(s) (oligo(s)) which is (are) effective for alleviating bronchoconstriction and/or lung inflammation, allergy(ies), and\or surfactant depletion and\or hyposecretion, when administered to a mammal, the oligo containing about 0 to about 15% adenosine and being anti-sense to a target selected from the group consisting of the initiation codon, the coding region, the 5'-end and the 3'-end genomic flanking regions, the 5' and 3' intron-exon junctions, and regions within 2 to nucleotides of the junctions of a gene encoding a target polypeptide associated with lung airway dysfunction or anti-sense to the polypeptide mRNA; combinations of the oligos; and mixtures of the oligos; and a pharmaceutically or veterinarily acceptable carrier or diluent. The targets are typically molecules associated with airway disease, cancer, etc., such as transcription factors, stimulating and activating peptide factors, cytokines, cytokine receptors, chemokines, chemokine receptors, adenosine receptors, bradykinin receptors, endogenously produced specific and nonspecific enzymes, immunoglobulins and antibodies, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non-nervous system peptide transmitters, adhesion molecules, defensins, growth factors, vasoactive peptides and receptors, binding proteins, and malignancy associated proteins, among others. Examples are oligo(s) targeted to adenosine receptor(s) and it(they) are typically present in the composition in an amount effective to reduce adenosine mediated effect(s), such as airway obstruction, inflammation, allergy(ies), and sufactant depletion, among others. The adenosine receptor is preferably selected from the group consisting of the adenosine A, A2b, and A 3 receptors, and in some instances even adenosine A2a receptors. The oligo of the invention may be applied to the preparation of a medicament for (a) reducing adenosine-mediated bronchoconstriction, impeded respiration, inflammation, allergy(ies), depletion production of surfactant, and other detrimental pulmonary effects in a subject in need of treatment, and/or for (b) treating specific diseases and conditions such as asthma, cystic fibrosis, allergic rhynitis, COPD, etc. For the first time this invention provides the targeted administration of one or more oligonucleotides directly into the repiratory system. The oligos may be directed to any target and are intended for fast delivery through the mucosal tissue of the lungs for hybridization to a desired target polynucleotide, e. g. mRNA, to prevent gene transcription and translation, such that protein expression will be reduced, hampered, or completely stopped. Thus, this invention also provides a more general method for administering oligonucleotides that are anti-sense to targeted genes and mRNAs associated with any type of diseases, by direct administration into the respiratory system, e. g. by inhalation, by introduction of a solution or aerosol into the respiratory airways, and/or directly into the lung.

The present oligos, moreover, are suitable for reducing effects mediated by a variety of target proteins and genes, for example adenosine-mediated effects, including pulmonary, respiratory, and other associated effects, e. g. bronchoconstriction, inflammation, immune mediated reactions, allergy(ies) and other airway problems, which may be caused by different conditions, including cancer. Examples of diseases and conditions, which may be treated preventatively, prophylactically and therapeutically with the agent of this invention, are pulmonary vasoconstriction, inflammation, allergies, asthma, impeded respiration, respiratory distress syndrome, pain, cystic fibrosis, allergic rhynitis, pulmonary hypertension, pulmonary vasoconstriction, emphysema, chronic obstructive pulmonary disease (COPD), bronchitis, and cancers such as leukemias, lymphomas, carcinomas, and the like, e.g. colon cancer, breast cancer, lung cancer, pancreatic cancer, hepatocellular carcinoma, kidney cancer, melanoma, hepatic metastases, etc., as well as all types of cancers which may metastasize or have metastasized to the lung(s), including breast and prostate cancer. The present agents are also suitable for administration before, during and after other treatments, including radiation, chemotherapy, antibody therapy, phototherapy and cancer, and other types of surgery. The present agent is effectively administered prophylactically and therapeutically in conjunction with other therapies, or by itself for conditions without known therapies or as a substitute for therapies that have significant negative side effects. The oligo(s) may be administered by any means known to a subject, e. g. to the lungs of the subject, more generally through any and all systemic and topical routes. This oligonucleotide(s) (oligo(s)) employed are anti-sense to to a target DNA or RNA, e. g.

an adenosine receptor DNA or RNA, and preferably consist essentially of up to about 15% adenosine and more preferably contain no adenosine. The oligos are provided in the form of specific compositions and formulations, with a carrier or diluent, and optionally with other therapeutic agents and additives which are used for administration by specific routes, e.g. into the respiratory system, topically, transdermally, parenterally, by implantation, and the like. The oligo is also provided as a capsule or cartridge, and in the form of a kit. The oligos of the invention may be produced by selection of specific targeted segments of the gene or mRNA encoding the adenosine receptor as described below.

In one preferred embodiment, the selection is made to obtain oligos that consisting essentially of less than about 15% adenosine This may be done by selecting the target as done above, which includes genes, genomic flanking regions, RNAs and polypeptide associated with an ailment afflicting the lung airways, obtaining the sequence of a mRNA(s) corresponding to the target gene(s) and/or their genomic flanking region(s) and/or the juxtamembrane regions thereof, and mRNA(s) encoding the target polypeptide(s), selecting at least one segment of the mRNA(s), and synthesizing one or more anti-sense oligonucleotide(s) to the selected mRNA segment(s), and substituting, if necessary, an alternative, e. g. a universal base(s) or other base(s) for one or more A to reduce the proportion of A present in the oligonucleotide to less than about 15%, and down to no adenosine.

Similarly, alternative and/or universal bases may be substituted for adenosine, e. g. specific adenosine Al, A2b and A3 receptor antagonists or A2a receptor agonists, theophilline, enprophylline, and many other adenosine receptor antagonists known in the art as well as agonists with significantly reduced agonist activity with respect to adenosine, e. g. less than less than and the like.

The invention will now be described in general in conceptual and experimental terms, with reference to specific examples. Other objects, advantages and features of the present invention will become apparent to those skilled in the art from the description that follows.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS This invention arose from a desire by the inventor to improve on prior art treatments for pulmonary and other diseases, which technology is generally frought with detrimental side effects and by the need of administering high doses of therapeutical agents. The present invention arises from the inventor's own discovery that adenosine receptor targeted anti-sense oligonucleotides (oligos) may be utilized therapeutically in the treatment of diseases or conditions which impair respiration, cause inflammation and/or allergy(ies), constrict bronchial tissue, obstruct the lung airways, depletion surfactant secretion, or otherwise impede normal breathing. In general, many diseases and conditions are associated with or cause inflammation, constrict bronchial tissue or the lung airways, depletion secretion of surfactant, augment allergy(ies), or otherwise impede normal breathing. This treatment is selective for specific targets associated with or mediating these symptoms, and the agents are administered in up to 1000-fold lower doses than those seen in the art. The inventor, in addition, wanted to provide a treatment which would improve the outcome and life style of patients undergoing other procedures or being administered other therapies, including antibody therapy, chemotherapy, radiation, phototherapy, and surgery e.g.

cancer surgery, and that could be effectively administered preventatively, prophylactically or therapeutically. He reasoned that he could further improve on this discovery by selecting oligos of reduced adenosine content, or reducing the adenosine content of otherwise targeted anti-sense oligos corresponding to endogenous polynucleotide sequences. The present invention is premised on the discovery by the inventor that oligonucleotides are metabolized in vivo to their mononucleotides. Adenosine (A)-containing oligonucleotides break down and release adenosine which, in turn, activates adenosine receptors, thereby causing* bronchoconstriction, inflammation, surfactant depletion, allergy(ies), and the like. He, thus, conceived of employing low adenosine-free adenosine oligos to avoid these side effects upon their administration. He succeeded in this endeavor and is providing in this patent novel and improved compositions, formulations and methods which afford greatly improved results when compared with previously known treatments for preventing and alleviating bronchoconstriction, allergy(ies), inflammation, breathing difficulties, surfactant depletion and blockage of airways, as well as for other conditions which affect the lung directly or indirectly.

In different embodiments, one or more nucleic acids of the invention may be formulated alone, and/or with one or more surfactant components and/or with a carrier, and/or with other therapeutic agents and/or formulation agents known in the art. The compositions of this invention, thus, may be incorporated into a variety of formulations for systemic and topical administration. Moreover, the inventor also provides a broad method for delivery of anti-sense oligonucleotides (oligos) through the respiratory system, as a fast means of starting treatment to address acute attacks of asthma and other diseases and conditions that have a rapid onset. In addition, the present agents have long halflives and may be administered at very low doses. This makes them ideal for once a week type therapies. In the past, anti-sense oligonucleotides received considerable theoretical consideration as being potentially useful as pharmacologic agents for the treatment of human disease.

Wagner, Nature 372: 333-335 (1994). However, it has been difficult to actually apply these molecules to alleviating and curing human diseases. One important consideration in the pharmacologic application of these molecules has been the failure of various routes of administration to deliver the compounds to its target while avoiding invading the circulation and, therefore, other untargeted tissues which, thus, produces a plethora of side effects. Most in vivo experiments utilizing antisense oligonucleotides involved a direct application of the oligo to limited regions of the brain. See, Wahlestedt, Trends in Pharmacol. Sci. 15: 42-46 (1994); Lai, J. et al., Neuroreport 5: 1049-1052 (1994); Standifer, et al., Neuron 12: 805-810 (1994); Akabayashi, et al., Brain Res. 21: 55-61 (1994).

Others applied them into the spinal fluid. See, e.g.

Tseng, et al., European J. Pharmacol. 258: R1-3 (1994); Raffa, et al., European J. Pharmacol. 258: R5-7 (1994); Gillardon, et al., European J. Neurosci.

6: 880-884 (1994). Such applications, clearly, have no practical clinical utility due to their invasive nature.

Thus, the systemic administration of anti-sense oligonucleotides poses significant problems with respect to their pharmacologic application, not the least of which is the difficulty in selectively targeting diseaseinvolved tissues. The systemic administration of antisense oligonucleotides also poses significant problems with respect to their pharmacologic application, not the least of which is the difficulty in selectively targeting disease-involved tissues.

The respiratory system, and in particular the lung, as the ultimate port of entry into the organism, however, is an excellent route of administration for anti-sense oligonucleotides. This is so not only for the treatment of lung disease, but also when utilizing the lung as a means for delivery, particularly because of its noninvasive and tissue-specific nature. Thus, local delivery of antisense oligonucleotides directly to the target tissue enables the therapeutic use of these compounds. Fomivirsen (ISIS 2302) is an example of a local drug delivery into the eye to treat cytomegalovirus (CMV) retinitis, for which a new drug application has been filed by ISIS. The administration of a drug through the lung offers the further advantage that inhalation is non-invasive whereas direct injection in to the vitreous of the eye is invasive. The composition and formulations of this invention are highly efficacious for preventing and treating diseases and conditions associated with bronchoconstriction, difficult breathing, impeded and obstructed lung airways, allergy(ies), inflammation and surfactant depletion, among others. Examples of diseases and conditions which are suitably treated by the present method are diseases and conditions, including Acute Respiratory Distress Syndrome (ARDS), asthma, adenosine administration e.g. in the treatment of SupraVentricular Tachycardia (SVT) and other arrhythmias, and in stress tests to hyper-sensitized individuals, ischemia, renal damage or failure induced by certain drugs, infantile respiratory distress syndrome, pain, cystic fibrosis, pulmonary hypertension, pulmonary vasoconstriction, emphysema, chronic obstructive pulmonary disease (COPD), lung transplantation rejection, pulmonary infections, and cancers such as leukemias, lymphomas, carcinomas, and the like, including colon cancer, breast cancer, lung cancer, pancreatic cancer, hepatocellular carcinoma, kidney cancer, melanoma, hepatic metastases, etc., as well as all types of cancers which may metastasize or have metastasized to the lung(s), including breast and prostate cancer. The invention will be described with respect to the adenosine receptors as targets, but is similarly applicable to any other target with respect to the pulmonary administration of anti-sense oligos. The examples provided below show a complete inhibition of such adenosine receptor associated symptoms in a rabbit model for human bronchoconstriction, allergy(ies) and inflammation as well as the elimination of the ability of the adenosine receptor agonist par excellence, adenosine, to cause bronchoconstriction in hyper-responsive monkeys, which are animal models for human hyper-responsiveness to adenosine receptor agonists. The pharmaceutical composition and formulations of the invention, therefore, are suitable for preventing and alleviating the symptoms associated with stimulation of adenosine receptors, such as the adenosine A, receptors. The compositions and formulations of this invention, thus, are also suitable for prevent the untoward side effects of adenosinemediated hyperresponsiveness in certain individuals, which are generally seen in diseases affecting respiratory activity.

The method of the present invention may be used to treat airway diseases and conditions in a subject of any kind and for any reason, with the intention that the adenosine content of anti-sense compounds be minimized, reduced or eliminated so as to prevent its liberation upon anti-sense degradation. Examples of diseases and conditions, which may be treated preventatively, prophylactically and therapeutically with the compositions and formulations of this invention, are pulmonary vasoconstriction, inflammation, allergies, asthma, allergic rhynitis, impeded respiration, Acute Respiratory Distress Syndrome (ARDS), renal damage and failure associated with ischemia as well as the administration of certain drugs, side effects associated with adenosine administration e.g. in SupraVentricular Tachycardia (SVT) and in adenosine stress tests, infantile Respiratory Distress Syndrome (infantile RDS), ARDS, pain, cystic fibrosis, pulmonary hypertension, pulmonary vasoconstriction, emphysema, chronic obstructive pulmonary disease (COPD), lung transplantation rjejection, pulmonary infections, and cancers such as leukemias, lymphomas, carcinomas, and the like, e.g. colon cancer, breast cancer, lung cancer, pancreatic cancer, hepatocellular carcinoma, kidney cancer, melanoma, metastatic cancer such as hepatic metastases, lung, breast and prostate metastases, among others. The present compositions and formulations are suitable for administration before, during and after other treatments, including radiation, chemotherapy, antibody therapy, phototherapy and cancer, and other types of surgery. The present compositions and formulations may also be administered effectively as a substitute for therapies that have significant negative side effects.The terms "anti-sense" oligonucleotides generally refers to small, synthetic oligonucleotides, resembling single-stranded DNA, which in this patent are applied to the inhibition of gene expression by inhibition of a target messenger RNA (mRNA). See, Milligan, J. F. et al., J. Med. Chem. 36(14), 1923-1937 (1993), the relevant portion of which is hereby incorporated in its entirety by reference. For consistency=s sake, all RNAs and oligonucleotides are represented in this patent by a single strand in the to 3' direction, when read from left to right, although their complementary sequence(s) is (are) also encompassed within the four corners of the invention. In addition, all nucleotide bases and amino acids are represented utilizing the recommendations of the IUPAC-IUB Biochemical Nomenclature Commission, or by the known 3letter code (for amino acids). Nucleotide sequences are presented herein by single strand only, in the 5' to 3' direction, from left to right. In addition, nucleotide and amino acids are represented herein in the manner recommended by the IUPAC-IUB Biochemical Nomenclature Commission, or (for amino acids) by three letter code, in accordance with 37 CFR 1.822 and established usage.

See, PatentIn User Manual, 99-102 (Nov. 1990) (U.S.

Patent and Trademark Office, Office of the Assistant Commissioner for Patents, Washington, D.C. 20231); U.S.

Patent No. 4,871,670 to Hudson et al. at col. 3, lines 20-43. The present method utilizes anti-sense agents to inhibit or down-regulate gene expression of target genes, including those listed in Tables 1 and 2 below. This is generally attained by hybridization of the anti-sense oligonucleotides to coding (sense) sequences of a targeted messenger RNA (mRNA), as is known in the art.

The exogenously administered agents of the invention decrease the levels of mRNA and protein encoded by the target gene and/or cause changes in the growth characteristics or shapes of the thus treated cells. See, Milligan et al. (1993); Helene, C. and Toulme, J.

Biochim. Biophys. Acta 1049, 99-125 (1990); Cohen, J. S.

Ed., Oligodeoxynucleotides as Anti-sense Inhibitors of Gene Expression; CRC Press: Boca Raton, FL (1987), the relevant portion of which is hereby incorporated in its entirety by reference. As used herein, "anti-sense oligonucleotide or asnti-sense oligo" is generally a short sequence of synthetic nucleotide that (1) hybridizes to any segment of a mRNA encoding a targeted protein under appropriate hybridization conditions, and which upon hybridization causes a decrease in gene expression of the targeted protein. The terms "desAdenosine" (desA) and "des-thymidine" (desT) refer to oligonucleotides substantially lacking either adenosine (desA) or thymidine (desT). In some instances, the des A or des T sequences are naturally occurring, and in others they may result from substitution of an undesirable nucleotide by another lacking its undesirable activity, such as acting as an agonist or having a triggering effect at the adenosine A receptor(s) In the present context, the substitution is generally accomplished by substitution of A with a "universal or alternative base", presently known in the art or to be ascertained at a later time. As used herein, the terms "prevent", "preventing", "treat" or "treating" refer to a preventative, prophylactic, maintenance, or therapeutic treatment which decreases the likelihood that the subject administered such treatment will manifest symptoms associated with adenosine receptor stimulation. The term "down-regulate" refers to inducing a decrease in production, secretion or availability and, thus, a decrease in concentration, of intracellular target product, be it a receptor e. g. adenosine A2b, A 3 bradykinin 2B, GATA-3, or other receptors, or an increase in concentration of the adenosine A2a receptor. The present technology relies on the design of anti-sense oligos targeted to mRNAs associated with ailments involving lung airway pathology(ies), and on their modification to reduce the occurrence of undesirable side effects caused by their release of adenosine upon breakdown, while preserving their activity and efficacy for their intended purpose. In this manner, the inventor targets a specific gene to design one or more anti-sense oligonucleotide(s) (oligos) that selectively bind(s) to the corresponding mRNA, and then reduces, if necessary, their content of adenosine via substitution with an alternative or a universal base, or an adenosine analog incapable of significantly, or having substantially reduced ability for, activating or antagonizing adenosine A, A2b or A 3 receptors or which may act as an agonist at the adenosine A2a, receptor. Any number of adenosines present may be substituted by an alternative and/or universal base, such as heteroaromatic bases, which binds to a thymidine base but has less than about 0.3 of the adenosine base agonist or antagonist activity at the adenosine A2a, A2b and A 3 receptors. Based on his prior experience in the field, the inventor reasoned that in addition to "downregulating" specific genes, he could increase the effect of the agent(s) administered by either selecting segments of RNA that are devoid, or have a low content, of thymidine or, alternatively, substitute one or more adenosine(s) present in the designed oligonucleotide(s) with other nucleotide bases, so called universal bases, which bind to thymidine but lack the ability to activate adenosine receptors and otherwise exercise the constricting effect of adenosine in the lungs, etc. Given that adenosine is a nucleotide base complementary to thymidine when a T appears in the RNA, the anti-sense oligo will have an A at the same position.

In one aspect of this invention, the anti-sense oligonucleotide has a sequence which specifically binds to a portion or segment of a mRNA molecule which encodes a protein associated with impeded breathing, allergy(ies), lung inflammation, depletion of lung surfactant or lowering of lung surfactant, airway obstruction, bronchitis, and the like. One effect of this binding is to reduce or even prevent the translation of the corresponding mRNA and, thereby, reduce the available amount of target protein in the subject=s lung. In one preferred embodiment of this invention, the phosphodiester residues of the anti-sense oligonucleotide are modified or substituted. Chemical analogs of oligonucleotides with modified or substituted phosphodiester residues, to the methylphosphonate, the phosphotriester, the phosphorothioate, the phosphorodithioate, or the phosphoramidate, methoxy ethyl and similar modifications, which increase the in vivo stability of the oligonucleotide are particularly preferred. The naturally occurring phosphodiester linkages of oligonucleotides are susceptible to some degree of degradation by cellular nucleases. Many of the residues proposed herein, on the contrary, are highly resistant to nuclease degradation. See, Milligan et al.; Cohen, J. S. supra. In another preferred embodiment of the invention, the oligonucleotides may be protected from degradation by adding a "3'-end cap" by which nuclease-resistant linkages are substituted for phosphodiester linkages at the 3' end of the oligonucleotide. See, Tidd, D. M. and Warenius, Be.

J. Cancer 60: 343-350 (1989); Shaw, J.P. et al., Nucleic Acids Res. 19: 747-750 (1991), the relevant section of which are incorporated in their entireties herein by reference. Phosphoramidates, phosphorothioates, and methylphosphonate linkages all function adequately in this manner for the purposes of this invention, as do C<' modifications, such as methoxy ethyl, and the like.

The more extensive the modification of the phosphodiester backbone the more stable the resulting agent, and in many instances the higher their RNA affinity and cellular permeation. See, Milligan, et al., supra. In addition, a plurality of substitutions to the carbohydrate ring are also known to improve stability of nucleic acids. Thus, the number of residues which may be modified or substituted will vary depending on the need, target, and route of administration, and may be from 1 to all the residues, to any number in between. Many different methods for replacing the entire phosphodiester backbone with novel linkages are known. See, Millikan et al, supra. Preferred backbone analogue residues include phosphoramidate, phosphorothioate, methylphosphonate, phosphorotriester, phosphotriester, thioformacetal, phosphorodithioate, phosphoramidate, formacetal, triformacetal, thioether, carbamate, boranophosphate, 3'thioformacetal, 5'-thioether, carbonate, Cs-substituted nucleotides, 5'-N-carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, 2'-O methyl, sulfoxide, sulfide, hydroxylamine, methylene(methylimino) (MMI), methoxymethyl (MOM), and methoxyethyl(MOE), and methyleneoxy(methylimino) (MOMI) residues, and combinations thereof. Phosphorothioate and methylphosphonate-modified oligonucleotides are particularly preferred due to their availability through automated oligonucleotide synthesis. See, Millikan et al, supra. Where appropriate, the agent of this invention may be administered in the form of their pharmaceutically acceptable salts, or as a mixture of the anti-sense oligonucleotide and its salt. In another embodiment of this invention, a mixture of different anti-sense oligonucleotides or their pharmaceutically acceptable salts is administered. A single agent of this invention has the capacity to attenuate the expression of a target mRNA and/or various agents to enhance or attenuate the activity of a pathway. By means of example, the present method may be practiced by identifying all possible deoxyribonucleotide segments which are low in thymidine or deoxynucleotide segments low in adenosine of about 7 or more mononucleotides, preferably up to about mononucleotides, more preferably about 10 to about 36 mononucleotides, and still more preferably about 12 to about 21 mononucleotides, in a target mRNA or a gene, respectively. This may be attained by searching for mononucleotide segments within a target sequence which are low in, or lack thymidine (RNA), a nucleotide which is complementary to adenosine, or that are low in adenosine (gene), that are 7 or more nucleotides long. In most cases, this search typically results in about 10 to 30 such sequences, i.e. naturally lacking or having less than about 40% adenosine, anti-sense oligonucleotides of varying lengths for a typical target mRNA of average length, about 1800 nucleotides long. Those with high content of T or A, respectively, may be fixed by substitution of a universal base for one or more As. The agent(s) of this invention may be of any suitable length, including but not limited to, about 7 to about nucleotides long, preferably about 12 to about 45, more preferably up to about 30 nucleotides long, and still more preferably up to about 21, although they may be of other lengths as well, depending on the particular target and the mode of delivery. The agent(s) of the invention may be directed to any and all segments of a target RNA.

One preferred group of agent(s) includes those directed to an mRNA region containing a junction between an intron and an exon. Where the agent is directed to an intron/exon junction, it may either entirely overlie the junction or it may be sufficiently close to the junction to inhibit the splicing-out of the intervening exon during processing of precursor mRNA to mature mRNA, e.g.

with the 3' or 5' terminus of the anti-sense oligonucleotide being positioned within about, for example, within about 2 to 10, preferably about 3 to nucleotide of the intron/exon junction. Also preferred are anti-sense oligonucleotides which overlap the initiation codon, and those near the 5' and 3' termini of the coding region. The flanking regions of the exons may also be targeted as well as the spliced segments in the precursor mRNAs. The mRNA sequences of the adenosine receptors and of many other targets are derived from the DNA base sequence of the gene expressing either receptors, e. g. the adenosine receptors, the enzymes, factors, or other targets associated with airway disease.

For example, the sequence of the genomic human Ai adenosine receptor is known and is disclosed in U.S.

Patent No. 5,320,963 to Stiles, et al. The A 3 adenosine receptor has been cloned, sequenced and expressed in rat (see, Zhou, et al., P.N.A.S. (USA) 89: 7432 (1992)) and human (see, Jacobson, M. et al., U.K. Patent Application No. 9304582.1 (1993)). The sequence of the adenosine A2b receptor gene is also known.

See, Salvatore, C. Luneau, C. Johnson, R. G. and Jacobson, Genomics (1995), the relevant portion of which is hereby incorporated in its entirety by reference. The sequences of many of the remaining exemplary target genes are also known. See, GenBank, NIH.

The sequences of those genes whose sequences are not yet available may be obtained by isolating the target segments applying technology known in the art. Once the sequence of the gene, its RNA and/or the protein are known, an anti-sense oligonucleotides may be produced according to this invention as described above to reduce the production of the targeted protein in accordance with standard techniques. The sequences for the adenosine A2a bradykinin, and other genes as well as methods for preparation of oligonucleotides are also known as those of many other target genes and mRNAs for which this invention is suitable. Thus, anti-sense oligonucleotides that downregulate the production of target sequences associated with airway disease, including the adenosine Al, A 2 a, A2b, A 3 bradykinin, GATA-3, COX-2, and many other receptors, may be produced in accordance with standard techniques. Examples of diseases and conditions which are suitably treated by the present method are diseases and conditions, including Acute Respiratory Distress Syndrome (ARDS), asthma, adenosine administration e.g. in the treatment of SupraVentricular Tachycardia (SVT) and other arrhythmias, and in stress tests to hypersensitized individuals, ischemia, renal damage or failure induced by certain drugs, infantile respiratory distress syndrome, pain, cystic fibrosis, pulmonary hypertension, pulmonary vasoconstriction, emphysema, chronic obstructive pulmonary disease (COPD), pulmonary transplantation rejection, pulmonary infections, and cancers such as leukemias, lymphomas, carcinomas, and the like, including colon cancer, breast cancer, lung cancer, pancreatic cancer, hepatocellular carcinoma, kidney cancer, melanoma, hepatic metastases, etc., as well as all types of cancers which may metastasize or have metastasized to the lung(s), including breast and prostate cancer.

The adenosine receptors discussed above are mere examples of the high power of the inventor=s technology.

In fact, a large number of genes may be targeted in a similar manner by the present agent(s), to reduce or down-regulate protein expression. By means of example, if the target disease or condition is one associated with impeded or reduced breathing, bronchoconstriction, chronic bronchitis, pulmonary bronchoconstriction and/or hypertension, chronic obstructive pulmonary disease (COPD), pulmonary transplantation rejection, pulmonary infections, allergy, asthma, cystic fibrosis, respiratory distress syndrome, cancers, which either directly or by metastasis afflict the lung, the present method may be applied to a list of potential target mRNAs, which includes the targets listed in Table 1 and Table 2 below, among others. The anti-sense agent(s) of the invention have a low A content to prevent its liberation upon in vivo degradation of the agent(s). For example, if the system is the pulmonary or respiratory system, a large number of genes is involved in different functions, including those listed in Table 1 below.

Table i: Pulmonary Disease or Condition Pulmonary and Inflammation Targets Nf6B Transcription Factor Interleuki Receptor (IL-8 R) Receptor (IL-5R) Interleuki Receptor (IL-4R) Interleukin-3 Receptor (IL-3R) Interleuki (IL- k R Interleukin-l<$ Receptor (IL-laR) Eotaxin n-8 n-4 n-16i Tryptase Major Basic A&2-adrenergic Receptor Kinase E Receptor A Endothelin Receptor B Prepro Bradykinin B2 Receptor (B2BR) IgE Receptor) Interleukin-1 (IL-1) Interl (IL-1 R) Interleukin-9 (IL-9) Interl (IL-9 R) Interleukin-11 (IL-11) Interl Receptor (IL-11 R) Inducible Nitric Oxide Synthase C

(COX)

Intracellular Adhesion Molecule 1 (I Cellular Adhesion Molecule Substance P (VCAM) Rantes Endothelial Adhesion Molecule Endothelin ETA Receptor (ELAM-1) Cyclooxygenase-2 (COX-2) GM-CSF, En Monocyte Activating Factor Neutro Factor Protein ndothelin endothelin (High Affinity eukin 1 Receptor eukin-9 Receptor eukin-11 yclooxygenase CAM-1) Vascular Leukocyte dothelin-1 phil Chemotactic Neutrophil Elastase Defensin 1,2,3 Muscarinic Acetylcholine Receptors Platelet Factor Tumor Necrosis Factor X 5-lipoxyg Phosphodiesterase IV Substance Substance P Receptor Histamine Chymase CCR-1 CC Chemokine Interleukin-2 (IL-2) Interleuk: Interleukin-12 (IL-12) Interleuk: Activating enase

P

Receptor Receptor in-4 (IL-4) in-5 Interleukin-6 (IL-6) Interleukin-8 (IL-8) Receptor (IL-12R) Interleukin-7 Receptor (IL-7R) (IL-1) Interleukin-14 Receptor (IL-14R) CCR-2 CC Chemokine Receptor Receptor CCR-4 CC Chemokine Receptor Receptor Interleukin-7 (IL-7) Interleukin-12 Interleukin-1 Interleukin-14 CCR-3 CC Chemokine CCR-5 CC Chemokine Prostanoid Receptors Factor Neutrophil Adherence Receptor (IL-is) Receptor Interleukin-il (IL-il) Receptor (IL-1iR) NFAT Transcription Factors MIP-ixK MCP-3 Cyclophillin B, etc.) Basic Fibroblast Growth Factor CSBP/p38 MAP Kinase PDG2 Inter Interleukin-lO (IL-10) Binding Protein FK506-Binding Protein Fibronect in GATA-3 Transcription MAP Kinase Interleukin- Interleukin- ii STAT 4 MCP-2 MCP-4 Phospholipase A2 Metalloproteinase Tryptase Receptor leukin-3 (IL-3) Cyclosporin A X<464.,7 Selectin Table 1: Pulmonary Disease or Condition Pulmonary and Inf lanamation Targets cMad CAM-i LFA-1 (CDlia/CD18) PECAN-i LFA-1 Selectin C3bi PSGL-1 E-Selectin P-Selectin CD-34 L-Selectin p150,95 Mac-i (CDiib/CDi8) Fucosyl transferase VLA-4 STAT-i STAT -2 CD-18/CDi1a CD11b/CD18 ICAM2 and ICAM3 CCR3 (Eotaxin Receptor) CCR1, CCR2, CCR4, LTB-4 AP-1 Transcription Factor Protein kinase C Receptor Tachykinnen Receptors (tach R) Interleukin-2 Receptor (IL-2R) P, NK-i NK-3 Receptors) STAT 6 NF-Interieukin-6 (NF-IL-6) Receptor Interieukin-3 (IL-3) (IL-2R) Interieukin-13 (IL-13) Receptor (IL-i2R) Interleukin-14 (IL-14) (IL-6R) Interleukin-16 (IL-i6) Receptor (IL-13R) Medullasin Cysteinyl Leukotriene 16B Kinase 1 2 Substance c -ma s Interleukin- Interleukin-2 Receptor Interleukin- 12 Interleukin-6 Receptor Interleukin- 13 Interleukin- 16 Rcpo Receptor (IL-16R) Adenosine Ai Receptor (At R) Tryptase-I Adenosine A2b Receptor (A2b R) Adenosine A 3 Receptor

(A

3

R)

w' Tryptase STAT-3 Adenosine A 2 a Receptor (A 2 a R) IgE Receptor ff Subunit (IgE R Fc-epsilon receptor CD23 antigen IgE Receptor Subunit (IgE R IgE Receptor Fc Epsilon Receptor (IgERFc R) Substance P Receptor Histidine decarboxylase Tryptase-1 Prostaglandin D Synthase Eosinophil Cationic Protein Eosinophil Derived Neurotoxin Eosinophil Peroxidase Endothelial Nitric Oxide Synthase Endothelial Monocyte Activating Factor Neutrophil Oxidase Factor Cathepsin G Macrophage Inflammatory Protein-1- Interleukin-8 Receptor Subunit (IL-8 RX<) Alpha/Rantes Receptor Endothelin Receptor

ET-B

These genes, and others, are involved in the normal functioning of respiration as well as in diseases associated with respiratory pathologies, including cystic fibrosis, asthma, pulmonary hypertension and vasoconstriction, chronic obstructive pulmonary disease (COPD), pulmonary transplantation rejection, pulmonary infections, chronic bronchitis, respiratory distress syndrome (ARDS), allergic rhinitis, lung cancer and lung metastatic cancers and other airway diseases, including those with inflammatory response.

Anti-sense oligos to the target receptors, e. g. the adenosine A2a, A2b, and A 3 receptors, CCR3 (chemokine receptors), bradykinin 2B, CAM (vascular cell adhesion molecule), and eosinophil receptors, among others, have been shown to be effective in down-regulating the expression of their genes. Some of these act to alleviate the symptoms or reduce respiratory ailments and/or inflammation, for example, by "down regulation" of the adenosine A2a, A2b, and/or A 3 receptors and CCR3, bradykinin 2B, VCAM (vascular cell adhesion molecule) and eosinophil receptors. These agents may be utilized by the present method alone or in conjunction with antisense oligos targeted to other genes to validate pathway and/or networks in which they are involved. For better results, the oligos are preferably administered directly into the respiratory system, by inhalation or other means, of the experimental animal, so that they may reach the lungs without widespread systemic dissemination. This permits the use of low agent doses as compared with those administered systemically or by other generalized routes and, consequently, reduces the number and degree of undesirable side effects resulting from the agent=s widespread distribution in the body. The agent(s) of this invention has (have) been shown to reduce the amount of receptor protein expressed by the tissue. These agents, thus, rather than merely interacting with their targets, e.g. a receptor, lower the number of target proteins that other drugs may interact with. In this manner, the present agent(s) afford(s) extremely high efficacy with low toxicity. Anti-sense oligonucleotides to the Ai A2b,

A

3 bradykinin B2, GATA-3, CAM (vascular cell adhesion molecule), eosinophil receptors, and COX-2 receptors, among others, have been shown to be effective in the down-regulation of the respective receptor proteins in the cell. One novel feature of this treatment, as compared to traditional treatments for adenosine-mediated bronchoconstriction, is that administration is direct to the lungs, or in situ to other tissues, organs or systems of the body. Additionally, a receptor protein itself is reduced in amount, rather than merely interacting with a drug, and toxicity is reduced. Other proteins that may be targeted with anti-sense agents for the treatment of lung conditions include, but are not limited to: CCR3 (chemokine) receptors, human A2a adenosine receptor, human A2b adenosine receptor, human IgE receptor 66, human Fcepsilon receptor CD23 antigen, human histidine decarboxylase, human beta tryptase, human tryptase-I, human prostaglandin D synthase, human cyclooxigenase-2, human eosinophil cationic protein, human eosinophil derived neurotoxin, human eosinophil peroxidase, human intercellular adhesion molecule-i (ICAM-1), human vascular cell adhesion molecule-1 (VCAM-1), human endothelial leukocyte adhesion molecule-1 (ELAM-1), human P selectin, human endothelial monocyte activating factor, human IL-3, human IL-4, human IL-5, human IL-6, human IL- 8, human monocyte-derived neutrophil chemotactic factor, human neutrophil elastase, human neutrophil oxidase factor, human cathepsin G, human defensin 1, human defensin 3, human macrophage inflammatory protein-lalpha, human muscarinic acetylcholine receptor HM3, human fibronectin, human GM-CSF, human tumor necrosis factor XC, human leukotriene C4 synthase, human major basic protein, and human endothelin i. Although not intended to be exclusive, a more extensive list of genes is provided below. Some of these act to alleviate the symptoms or reduce respiratory ailments and/or inflammation, for example, by "down regulation" of the adenosine A2a, A2b, and/or A 3 receptors and CCR3, bradykinin 2B, VCAM (vascular cell adhesion molecule) and eosinophil receptors. These agents are preferably administered directly into the respiratory system, by inhalation or other means, so that they may reach the lungs without widespread systemic dissemination. This permits the use of substantially lower doses of the agent of the invention as compared with those administered by the prior art, systemically or by other generalized routes and, consequently, reduce undesirable side effects resulting from the agent=s widespread distribution in the body. The agent(s) of this invention has (have) been shown to reduce the amount of receptor protein expressed by the tissue. These agents, thus, rather than merely interacting with their targets, e.g. a receptor, lower the number of target proteins that other drugs may interact with. In this manner, the present agent(s) afford(s) extremely high efficacy with low toxicity. In these latter targets, and in target genes in general, it is particularly imperative to eliminate or reduce the adenosine content of the corresponding anti-sense oligonucleotide to prevent their breakdown products from liberating adenosine.

As used herein, the term "treat" or "treating" asthma refers to a treatment which decreases the likelihood that the subject administered such treatment will manifest symptoms of the lung disease. The term "downregulate" refers to inducing a decrease in production, secretion or availability (and thus a decrease in concentration) of the targeted intracellular protein. The present invention is concerned primarily with the treatment of human subjects. However, the agents and methods disclosed here may also be employed for veterinary purposes, such as is the case in the treatment of other mammals, such as cattle, horses, wild animals, zoo animals, and domestic animals, e. g. dogs and cats.

Targeted proteins are preferably mammalian and more preferably of the same species as the subject being treated. In general, "anti-sense" refers to the use of small, synthetic oligonucleotides, resembling singlestranded DNA, to inhibit gene expression by inhibiting the function of the target messenger RNA (mRNA).

Milligan, J. F. et al., J. Med. Chem. 36(14), 1923-1937 (1993). In the present invention, inhibition of gene expression of the Al or A 3 adenosine receptor is desired.

Gene expression is inhibited through hybridization to coding (sense) sequences in a specific messenger RNA (mRNA) target by hydrogen bonding according to Watson- Crick base pairing rules. The mechanism of anti-sense inhibition is that the exogenously applied oligonucleotides decrease the mRNA and protein levels of the target gene or cause changes in the growth characteristics or shapes of the cells. Id. See, also Helene, C. and Toulme, Biochim. Biophys. Acta 1049, 99-125 (1990); Cohen, J. S. Ed., Oligodeoxynucleotides as Anti-sense Inhibitors of Gene Expression; CRC Press: Boca Raton, FL (1987) As used herein, "anti-sense oligonucleotide" is defined as a short sequence of synthetic nucleotide that (1) hybridizes to any coding sequence in an mRNA which codes for the targeted protein, according to hybridization conditions described below, and upon hybridization causes a decrease in gene expression of the Al or A 3 adenosine receptor. The receptors discussed above are mere examples of the high power of the present technology. In fact, a large number of genes may be targeted in a similar manner by practicing the present methods, to significantly down-regulate or obliterate protein expression and observe any changes wrought to one or more functions within a system, e.g. the respiratory system and other lung disease associated targets. By means of example, in the respiratory system, the targets may be associated with difficulties of breathing, bronchoconstriction, inflammation, allergic rhynitis, chronic bronchitis, surfactant depletion, and others associated with diseases and conditions such as chronic obstructive pulmonary disease (COPD), pulmonary transplantation rejection, pulmonary infections, inhalation burns, Acute Respiratory Distress Syndrome (ARDS), cystic fibrosis, pulmonary fibrosis, radiation pulmonitis, tonsilitis, emphysema, dental pain, oral inflammation, joint pain, esophagitis, cancers afflicting the respiratory system either directly such as lung cancer, esophageal cancer, and the like, or indirectly by means of metastases, among others. These functions are of great interest because of their association with respiratory dysfunction, as is the case in asthma, allergies, allergic rhinitis, pulmonary bronchoconstriction and hypertension, chronic obstructive pulmonary disease (COPD), pulmonary transplantation rejection, pulmonary infections, allergy, asthma, cystic fibrosis Acute Respiratory Distress Syndrome (ARDS) as well as infantile and pregnancy-related RDS, cancer, etc., which either directly or by metastasis afflict the lung, the present anti-sense oligonucleotides may be directed to a list of target mRNAs, which includes the targets listed in Table 1 above, among others.

The oligos of this invention may be obtained by first selecting fragments of a target nucleic acid having at least 4 contiguous nucleic acids selected from the group consisting of G and C and/or having a specific type and/or extent of activity, and then obtaining a first oligonucleotide 4 to 60 nucleotides long which comprises the selected fragment and has a thymidine nucleic acid content of up to and including about preferably, about 12%, about 10%, about about about about and more preferably no thymidine. The latter step may be conducted by obtaining a second oligonucleotide 4 to 60 nucleotides long comprising a sequence which is anti-sense to the selected fragment, the second oligonucleotide having an adenosine base content of up to and including about 15%, preferably about 12%, about 10%, about about about about and more preferably no adenosine. When the selected fragment comprises at least one thymidine base, an adenosine base may be substituted in the corresponding anti-sense nucleotide fragment with a universal base selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have less than about bout 10%, preferably less than about and more preferably less than about 0.3% of the adenosine base agonist activity at the adenosine A2a, A2b and A 3 receptors, and heteroaromatic bases which have no activity at the adenosine A2a receptor, when validating in the respiratory system. Other adenosine activities in other systems may be determined in other systems, as appropriate. The analogue heteroaromatic bases may be selected from all pyrimidines and purines, which may be substituted by 0, halo, NH 2 SH, SO, S02, SO 3 COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by O, halo, NH 2 primary, secondary and tertiary amine, SH, SO,

SO

2

SO

3 cycloalkyl, heterocycloalkyl and heteroaryl. The pyrimidines and purines may be substituted at all positions as is known in the art, but preferred are those which are substituted at positions 1, 2, 3, 4, 7 and/or 8. More preferred are pyrimidines and purines such as theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula wherein R 1 and R 2 are independently H, alkyl, alkenyl or alkynyl and R 3 is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, O-cycloalkyl, Ocycloalkenyl, O-cycloalkynyl, NH 2 -alkylaminoketoxyalkyloxy-aryl, mono and dialkylaminoalkyl-Nalkylamino-SO 2 aryl, among others. Similar modifications in the sugar are also embodiments of this invention.

Reduced adenosine content of the anti-sense oligos corresponding to the thymidines present in the target RNA serves to prevent the breakdown of the oligos into products that free adenosine into the system, e.g. the lung, brain, heart, kidney, etc., tissue environment and, thereby, to prevent any unwanted effects due to it. By means of example, the Nf6B transcription factor may be selected as a target, and its mRNA or DNA searched for low thymidine or desthymidine (desT) fragments. Only desT segments of the mRNA or DNA are selected which, in turn, will produce desA anti-sense as their complementary strand. When a number of RNA desT segments are found, the sequence of the anti-sense segments may be deduced. Typically, about 10 to 30 and even larger numbers of desA anti-sense sequences may be obtained.

These anti-sense sequences may include some or all desA anti-sense oligonucleotide sequences corresponding to desT segments of the mRNA of the target, such as anyone of those shown in Table 1 above, in Table 2 below, and others associated with functions of the brain, cardiovascular and renal systems, and many others. When this occurs, the anti-sense oligonucleotides found are said to be 100% A-free. For each of the original desA anti-sense oligonucleotide sequences corresponding to the target gene, e.g. the NF6B transcription factor, typically about 10 to 30 sequences may be found within the target gene or RNA which have a low content of thymidine (RNA). In accordance with this invention, the selected fragment sequences may also contain a small number of thymidine (RNA) nucleotides within the secondary or tertiary or quaternary sequences. In some cases, a large adenosine content may suffice to render the anti-sense oligonucleotide less active or even inactive against the target. In accordance with this invention, these so called "non-fully desA" sequences may preferably have a content of adenosine of less than about about 12%, about 10%, about about and about 2% adenosine. Most preferred is no adenosine content In some instances, however, a higher content of adenosine is acceptable and the oligonucleotides still fail to show detrimental "adenosine activity". A particular important embodiment is that where the adenosine nucleotide is "fixed" or replaced by a "Universal or alternative" base that may base-pair with similar or equal affinity to two or more of the four nucleotide present in natural DNA: A, G, C, and T.

A universal or alternative base is defined in this patent as any compound, more commonly an adenosine analogue, which has substantial capacity to hybridize to thymidine, while at the same time having reduced, or substantially lacking, ability to bind adenosine 27 receptors or other molecules through which adenosine may exert an undesirable side effect in the experimental animal or in a cell system. Alternatively, adenosine analogs which completely fail to activate, or have significantly reduce ability for activating, adenosine receptors, such as the adenosine A2b and/or A 3 receptors, most preferably Ai receptors, and those that may even act as agonists of the adenosine A2a, receptor, may be used. One example of a universal base is deoxyribofuranosol-(5-nitroindole), and an artisan will know how to select others. This "fixing" step generates further novel sequences, different from those anti-sense to the ones found in nature, that permits the anti-sense oligonucleotide to bind, preferably equally well, with the target RNA. Other examples of universal or alternative bases are Other examples of universal bases are 3 nitropyrrole 2' deoxynucleoside, 5 nitro-indole, 2 deoxyribosyl (5 nitroindole), 2-deoxyribofuranosyl nitroindole), 2' deoxyinosine, 2' -deoxynebularine, 6H, 8H-3,4-dihydropyrimido 4, 5 c] oxazine 7 one and 2 amino 6 -methoxy aminopurine. In addition to the above, Universal bases which may be substituted for any other base although with somewhat reduced hybridization potential, include 3 nitropyrrole 2' deoxynucleoside 2 deoxyribofuranosyl (5 nitroindole), 2' deoxyinosine and 2' deoxynebularine (Glen Research, Sterling, VA). More specific mismatch repairs may be made using nucleotide, 6H, 8H 3, 4 dihydropyrimido [4,5 c] 2] oxazin 7 one, which base pairs with either guanine or adenine and nucleotide, 2 amino 6 methoxyaminopurine, which base pairs with either cytidine or thymidine among others.

Others which are known in the art or will become available are also suitable. See, for example, Loakes, D. and Brown, D. Nucl. Acids Res. 22:4039-4043 (1994); Ohtsuka, E. et al., J. Biol. Chem.260(5):2605- 2608 (1985); Lin, P.K.T. and Brown, D. Nucleic Acids Res. 20(19):5149-5152 (1992; Nichols, R. et al., Nature 369(6480): 492-493 (1994); Rahmon M. S. and Humayun, N.

Mutation Research 377 263-8 (1997); Amosova, 0., et al., Nucleic Acids Res. 25 1930-1934 (1997); Loakes D. Brown, D. Nucleic Acids Res. 22 4039-4043 (1994), the entire sections relating to universal bases and their preparation and use in nucleic acid binding being incorporated herein by reference.

When non-fully desT sequences are found in the naturally occurring target, they typically are selected so that about 1 to 3 universal base substitutions will suffice to obtain a 100% "desA" anti-sense oligonucleotide. Thus, the present method provides either anti-sense oligonucleotides to different targets which are low in, or devoid of, A content, as well as anti-sense oligonucleotides where one or more adenosine nucleotides, e. g. about 1 to 3, or more, may be "fixed" by replacement with a "Universal" or "replacement" base.

Universal bases are known in the art and need not be listed herein. An artisan will know which bases may act as universal bases, and replace them for A. Table 2 below provides a selected number of targets to which the agents of the invention are effectively applied. Others, however, may also be targeted.

Table 2: Cancer Targets Transforming Therapy Oncogenes Targets ras thymidylate synthetase src thymidylate synthetase myc dihydrofolate reductase bcl-2 thymidine kinase deoxycytidine kinase ribonucleotide reductase Angiogenesis factors Adhesion Molecules Oncogenes Folate Pathway Enzymes DNA repair genes (One Carbon Pool) Telomerase HMG CoA Reductase Farnesyl Transferase Glucose-6-Phosphate Transferase A group of preferred targets for the treatment of cancer are genes associated with any of different types of cancers, or those generally known to be associated with malignancies, whether they are regulatory or involved in the production of RNA and/or proteins.

Examples are transforming oncogenes, including, but not limited to, ras, src, myc, and BCL-2, among others. Other targets are those to which present cancer chemotherapeutic agents are directed to, such as various enzymes, primarily, although not exclusively, thymidylate synthetase, dihydrofolate reductase, thymidine kinase, deoxycytidine kinase, ribonucleotide reductase, and the like. The present technology is particularly useful in the treatment of cancer ailments given that traditional cancer therapies are fraught with the unresolved problem of selectively killing cancer cells while preserving normal living cells from the devastating effects of treatments such as chemotherapy, radiotherapy, and the like. The present technology provides the ability of selectively attenuating or enhancing a desired pathway or target. This approach provides a significant advantage over standard treatments of cancer because it permits the selection of a pathway, including primary, secondary and possibly tertiary targets, which are not generally expressed simultaneously in normal cells. Thus, the present agent may be administered to a subject to cause a selective increase in toxicity within tumor cells that, for instance, express all three targets while normal cells that may expresses only one or two of the targets will be significantly less affected or even spared. A group of preferred targets for the treatment of cancers are genes associated with different types of cancers, or those generally known to be associated with malignancies, whether they are regulatory or involved in the production of RNA and/or proteins. Examples are transforming oncogenes, including, but not limited to, ras, src, myc, and BCL-2, among others. Other targets are those to which present cancer chemotherapeutic agents are directed to, such as various enzymes, primarily, although not exclusively, thymidylate synthetase, dihydrofolate reductase, thymidine kinase, deoxycytidine kinase, ribonucleotide reductase, and the like.

In one embodiment, at least one of the mRNAs to which the oligo of the invention is targeted encodes a protein such as transcription factors, stimulating and activating factors, intracellular and extracellular receptors and peptide transmitters in general, interleukins, interleukin receptors, chemokines, chemokine receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non-nervous system peptide transmitters, adhesion molecules, defensines, growth factors, vasoactive peptides and receptors, and binding proteins, among others; or the mRNA is corresponding to an oncogene and other genes associated with various diseases or conditions. Examples of target proteins are eotaxin, major basic protein, preproendothelin, eosinophil cationic protein, P-selectin, STAT 4, MIP-1<, MCP-2, MCP-3, MCP-4, STAT 6, c-mas, NF-IL-6, cyclophillins, PDG2, cyclosporin A-binding protein, binding protein, fibronectin, LFA-1 (CDlla/CD18), PECAM- 1, C3bi, PSGL-1,CD-34, substance P, p150,95, Mac-1 (CD1lb/CD18), VLA-4, CD-18/CD1la, CDllb/CD18, C5a, CCR1, CCR2, CCR4, CCR5, and LTB-4, among others. Others are, however, suitable, as well. In another embodiment, at least one of the mRNAs to which the oligo is targeted encodes intracellular and extracellular receptors and peptide transmitters such as sympathomimetic receptors, parasympathetic receptors, GABA receptors, adenosine receptors, bradykinin receptors, insulin receptors, glucagon receptors, prostaglandin receptors, thyroid receptors, androgen receptors, anabolic receptors, estrogen receptors, progesterone receptors, receptors associated with the coagulation cascade, adenohypophyseal receptors, adenohypophyseal peptide transmitters, and histamine receptors (HisR), among others. However others are also contemplated. The encoded sympathomimetic receptors and parasympathomimetic receptors include acetylcholinesterase receptors (AcChaseR) acetylcholine receptors (AcChR), atropine receptors, muscarinic receptors, epinephrine receptors (EpiR), dopamine receptors (DOPAR), and norepinephrine receptors (NEpiR), among others. Further examples of encoded receptors are adenosine Ai receptor, adenosine A 2 B receptor, adenosine

A

3 receptor, endothelin receptor A, endothelin receptor B, IgE high affinity receptor, muscarinic acetylcholine receptors, substance P receptor, histamine receptor, CCR- 1 CC chemokine receptor, CCR-2 CC chemokine receptor, CCR-3 CC chemokine receptor (Eotaxin Receptor), receptor (IL-l1/R), interleukin-1 receptor (IL-1R), interleukin-l1 receptor (IL-lIR), interleukin-3 receptor (IL-3R), CCR-4 CC chemokine receptor, cysteinyl leukotriene receptors, prostanoid receptors, GATA-3 transcription factor receptor, interleukin-1 receptor (IL-1R), interleukin-4 receptor (IL-4R), interleukin-5 receptor (IL-5R), interleukin-8 receptor (IL-8R), interleukin-9 receptor (IL-9R), interleukin-11 receptor (IL-11R), bradykinin B2 receptor, sympathomimetic receptors, parasympathomimetic receptors, GABA receptors, adenosine receptors, bradykinin receptors, insulin receptors, glucagon receptors, prostaglandin receptors, thyroid receptors, androgen receptors, anabolic receptors, estrogen receptors, progesterone receptors, receptors associated with the coagulation cascade, adenohypophyseal receptors, and histamine receptors (HisR). Others are also contemplated even though not listed herein. The encoded enzymes for development of the oligos of the invention include synthetases, kinases, oxidases, phosphatases, reductases, polysaccharide, triglyceride, and protein hydrolases, esterases, elastases, and polysaccharide, triglyceride, lipid, and protein synthases, among others.

Examples of target enzymes are tryptase, inducible nitric oxide synthase, cyclooxygenase (Cox), MAP kinase, eosinophil peroxidase, A2-adrenergic receptor kinase, leukotriene c-4 synthase, phosphodiesterase IV, metalloproteinase, tryptase, CSBP/p38 MAP kinase, neutrophil elastase, phospholipase

A

2 cyclooxygenase 2 (Cox-2), fucosyl transferase, chymase, protein kinase C, thymidylate synthetase, dihydrofolate reductase, thymidine kinase, deoxycytidine kinase, and ribonucleotide reductase, among others. Any enzyme associated with a disease or condition, however, is suitable as a target for this invention. Suitable encoded factors for application of this invention are, among others, Nf6B transcription factor, granulocyte macrophage colony stimulating factor (GM-CSF), AP-1 transcription factor, GATA-3 transcription factor, monocyte activating factor, neutrophil chemotactic factor, granulocyte/macrophage colony-stimulating-factor (G-CSF), NFAT transcription factors, platelet activating factor, tumor necrosis factor (TNF and basic fibroblast growth factor (BFGF). Additional factors are also within the invention even though not specifically mentioned. Suitable adhesion molecules for use with this invention include intracellular adhesion molecules 1 (ICAM-1), 2 (ICAM-2) and 3 (ICAM-3), vascular cellular adhesion molecule (VCAM), endothelial leukocyte adhesion molecule-1 (ELAM-1), neutrophil adherence receptor, mad CAM-1, and the like. Other known and unknown factors (at this time) may also be targeted herein. Among the cytokines, lymphokines and chemokines preferred are interleukin-1 interleukin-l. (IL-166), interleukin-3 interleukin-4 interleukin-8 interleukin-9 (IL-9), interleukin-11 (IL-11),CCR-5 CC chemokine, and Rantes.

Others, however, may also be targeted, as they are known to be involved in specific diseases or conditions to be treated, or for their generic activities, such as inflammation. Examples of defensins for the practice of this invention are defensin 1, defensin 2, and defensin 3, and of selectins are <464l selectin, <4aw7 selectin, LFA-1 selectin, E-selectin, P-selectin, and L-selectin.

Examples of oncogenes, although not an all inclusive list, are ras, src, myc, and bcBCL. Others, however, are also suitable for use with this invention.

The agents administered in accordance with this invention are preferably designed to be anti-sense to target genes and/or mRNAs related in origin to the species to which it is to be administered. When treating humans, the agents are preferably designed to be antisense to a human gene or RNA. The agents of the invention encompass oligonucleotides which are anti-sense to naturally occurring DNA and/or RNA sequences, fragments thereof of up to a length of one base less than the targeted sequence, preferably at least about 7 nucleotides long, oligos having only over about 0.02%, more preferably over about still more preferably over about and even more preferably over about 4% adenosine nucleotides, and up to about 30%, more preferably up to about 15%, still more preferably up to about 10% and even more preferably up to about adenosine nucleotide, or lacking adenosine altogether, and oligos in which one or more of the adenosine nucleotides have been replaced with so-called universal bases, which may pair up with thymidine nucleotides but fail to substantially trigger adenosine receptor activity. Examples of human sequences and fragments, which are not limiting, of anti-sense oligonucleotide of the invention are the following fragments as well as shorter segments of the fragments and of the full gene or mRNA coding sequences, exons and intron-exon junctions encompassing preferably 7, 10, 15, 18 to 21, 24, 27, n-1 nucleotides for each sequence, where n is the sequence=s total number of nucleotides. These fragments may be selected from any portion of the longer oligo, for example, from the middle, end, end or starting at any other site of the original sequence. Of particular importance are fragments of low adenosine nucleotide content, that is, those fragments containing less than or about 30%, preferably less than or about 15%, more preferably less than or about 10%, and even more preferably less than or about and most preferably those devoid of adenosine nucleotide, either by choice or by replacement with a universal base in accordance with this invention. The agent of the invention includes as a most preferred group sequences and their fragments where one or more adenosines present in the sequence have been replaced by a universal base as exemplified here.

Similarly, also encompassed are all shorter fragments of the B-containing fragments designed by substitution of B(s) for adenosine(s) contained in the sequences, fragments thereof or segments thereof, as described above. A limited list of sequences and fragments is provided below.

Some of the examples of anti-sense oligonucleotide sequence fragments target the initiation codon of the respective gene, and in some cases adenosine is substituted with a universal or alternative base adenosine analogue denoted as which lacks ability to bind to the adenosine Ai and/or A 3 receptors. In fact, such replacement nucleotide acts as a "spacer". Many of the examples shown below provide one such sequence and many fragments overlapping the initiation codon, preferably wherein the number of nucleotides n is about 7, about 10, about 12, about 15, about 18, about 21 and up to about 28, about 35, about 40, about 50, about Human Receptor-related Antisense Polynucleotide AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG C TGCTTTTCT TTTCTGGGCC TCTGTGGTCT GTTTTTTCT GGCCCTGCTG GGGCGCTCTC CGCCGCCCGC CTGGCTCCCG GBGCCCBTGB TGGGCBTGCC GTGGTTCTTG CCCTCCTTTG GCTGCCGTGC CCGCTCCCCG GCCTCCTGGC GGGTGGCCGT TGGGCCCGTG TTCCCCTGGG GCCTGGGGCT CCCTrCTCTC GCCCTTCTTG CTGGGCCTCT GCTGCTGCTG Page(s) 3 4l 6 are claims pages They appear after the sequence listing(s) GTGCTGTGGC GGCCGTACA GCGAGGAGGC CATGATGGGC ATGGGACAGA CGACAGGCGT BCBCGGBGGB OCCGBTGBTG GGCBTGCCBC BGBCGBCBGG C GGC 0CC GT0 GCG CGT CUT GGT GGG GG GOG OU CG GCC CGC GCG GGG CCC GIG CGG TCC GTT GC 0CC CGC GCG GGG CCC CTC CGG ICC CGG GTC GGG GCC CCC CG GGC C GCC TCG GGG CTG GGG CGC TOG TGG GCG GG CGG CGC CTC CGC GTG GCG CUT CTG GGT GGG CCC CGG GCG CCC CGT CCC CTC TTG CTC GGG TCC CCG TO ACA GGG COT CCT GTG TCT CCA OCA GCA TGG CCG GGC CAG CTG GGC CCC BCB GCG CGT CCI GTG TCT CCB GCB GCB TGG CCG GGC CBG CTG GGC CCC ACA GAG GAG TG TGT TGT TGG GCA TCT TGC CUT CCC AGG G BCB GBG GB TGC TGT TGT TGG GCB TCT TGC CUT CCC BGG GCC CUT UC TGG TGG GGT GGT OCT G17 GTT GGG CU7 TCT TCT GUT CCC BCB GBG CBG TG TGT TGT TGG GCB TCT TG CUT CCC BOO GCG CUT UG TOO TGG GGT GGT GCT GTT OUT GGG C TTU CUT CTG TTC CC TUT CCC CTG GGT CU7 CC CTC CTG CTC T U-T C ATT TGC TCT CCI AUT ACT TTG TGT GTC CAT UTT UTC ATT AAC CGA GCT GT BTT TGC TCT CCI BUT BGT UTC TOT OTC CBT U T UGC BU BBC COB OCT 010GCC TOT GTC TOT CCT CCT OCT TCG UTC CTC ICO UTC CIG CTT GOT 0CC CUT 0CC 0G G TG CTC CTC COO OCT GTO 0 GTC OTO 0CC CIG OCT CCG OCT GOT 000 CTC CCC TOG CGT ICO CTG OCT GOC GOC OTO C 000 TGT TG TCT 000 CCT GG TOT GG GG GOT TOG 000 TCT TC OCT 0CC ICC GUT TOG 010 GC TGI GTG AAT AUT GAG CUT GCT CCA TOO COG TCC TOG UTG OAT TCT CCC GA ICT CTG BBT BUT OBC CUT GCT CCB TOO COO TGG TG UTG OBI TCT CCC GB 0CC UTT CCI GOT ICT CTT GUT GUT 1T 000 OTT TOO CIT ACA OTA GAO TAO 000 ATT CGA TOG GAG GAG CGA TCT ICT IGA TOO ACT CC UGF AAG GAO ACC UTA GOT U-C IGA 000 ACT OCT AAC AG GCA ICT OGA GC BGB OTB OBO TBO 000 BIT CGB TOG CBO OBO CGB TCT ICI 1GB 100 BGT CC U-C BBO OBG BCC UTB GOT TIC lOB 000 BCT OCT BBC BG CCB TCT GOB G GU1 OU T 00 GUOT TOO CUT 0CC TTT CCI GOT ICI CU- BCB OTB OBO IBO 000 BTT CGB TOOGB B GG B ICT ICI 1GB TOO BCT CC 1TG BBO OBO BCC UTB GOT UTC TOB 000 BCT OCT BBC BCG CCB ICT GOB G 0CC 101 GIG TOT CCI CCI OCT TGG ITG GIG TCG UTC GI CIT 0010GCC CU- 0CC 0 GIG GIG GIG GIG COO OCT GIG 0 OTC GIG 0CC GIG OCT CCG OCT 001 000 GIG CCC 100 CCI TG CG OCT GG GOC GIG C CCC BOB BCO BOB CCC GOB CG BCB GGG GOT GOT TOG 000 ICI IC OCT 0CC ICC OUT TOG GIG G OAT GIG IGA AlA UTGA CCI ICC AT G GG GICG CU- OGA OBI GIG 1GB BIB UTGB CCI ICC BIGOG GG GI CG CU- GOB ICI 000 010 ICC TOO CCI ICO TOO UTC GIG UG CUT COT UTG CG ICC GO 000 0CC CCC 000 CCI GG TG OCT CCI 0CC CGG CCI CUT ICC COO OCT CII GOGC GIG0 GOT OCT CC COT GIG UrT OCO CCC IC GIG GIG GICG CTI GIG GUT UG 000 CG OCT UTG CCC 0CC ICC COO CG GIG GC COG CC UGr GIG GOC TG GIG COG OTU GIG TTC UGC UC CGGOCT GIG 000 101 CCI GG CUT COT GOT ICC ICT ICC UTC OTT TOG GOT CG COO 000 CCC CCG GG CT GG TG OCT CCI 0CC CG CCI CUF ICC COG OCT CII GOGC GG0 GOT OCT CCC GIG TOT ITO COG CCI CCI CCI GOT COG OCT TOT GT UTT GO GG COG CUT TG CG CCI CCC GOG 0CC 100 CCC GOC CUT CCI 000 GIG COT OCO COT ICT OUT CUT CU CCI GG GA OGA GAG AGO GCA 000 COA ICA OGA GA GO IGA 0CC AAA OGA OGA GGA G OGA AG GAOG COCG AAC GA OGA GAG AGO TG C GC BOG BOB CBO GG BOG GO BIG BOO BG BG GIG BG CBB BOG BOG BCC BICGG0 BBC 0GCB OCT CCG GBB CG BOG BCB OBO GIG CC ICI 0CC GIG ICC 0CC GOC ICT ICO 010 OCT COG CCC CG TCC UTG ICI TG CG 000 UTG OTT CCI 000 CCI GOT ICI TG 000 COT UGC GOT GIG GIG OCT 001 GIG GOC GCG COO TG GG 000 100 CUT OCT OTU GIG CCI 000 GIG ICC CCI GIG GIG CUT UC ICC CUr CCI GIG ICT TG GIG CU- CCI CGGO0 CCI CUT GG GIG GOC OCT CUT CCC GIG 000 COG GIG COG OCO GIG GIG GIG CCI GOT CCG GIG CCI 000 GOT OCT CCI ICC CU- ICC GGCG 010GT 00G ]OO 00 GIG G G G TOG CCI G 000 0(30 IG00 CCI UT 000 GIG GG TOO GIG GIG CUT COG 0CC 0CC TOO OCT ICC GIG TG CCC iT1 CCI GIG CGGO0 CCC CCI CCC OTT CGA AG TG ACC GA CG ACC GG OCT ACA OGA CG AOC GAG GA AG ACC CAT 000 OAT CCA GG CCA OCT OUT CCB BG TG BCC GB CBO BCC GOC OCT BCB GOB CBO BG GBG GB BG BCC CBI 000 OBI GCB GG GCB OCT 0 CICAGTGGGC CCCAAAAGGA TGAGTAATAG AIGAIGATAT CUUrTAGT ATOAGGGT GICGGGG TCTTICCUT GTCUTGOG OIOCCCIOCC TGTCIOGCCCG IGICIGIG GTC'rrrCCTr TGTCUTGOT GIGICUTTOG CTGTGTOGG GOGICTOG GTOGTCGTC iTfCTCUOG OTGTGICTUT OCIGTGGGI OGGOTGI ICCOGC!GG TGICTGOGG GIGGCOICCC IGOGGC!GC GGOGOCIG CTCTGOCCG GCOGGGO GOOGGOCO GTGGCG GOCOGCTGCCC TGGGGGC GTGGGI GGIOGOGOG TOCGGCOG CCTGCTGGCC OCOCCOGG CGGCCOCCI TOGICGG CUOGUCTCC GOGCIG CIGGOTOG OCTOGGOOC GGCGGG TCGOGGGOOG GGO-CTGUGCC GGGGIC CCTCCGGGGC GGGGGT[TCI GOCGGGG GGICCOGOIGG I CCGGUOT GUOGCCG UTCICTGGIC OGUTOOTCT COGGICCO GOCCCG1TTT GIGTOITGC TITTCCCIOG OCGICCGTGT GGGGCTCTCG ICIGCCIC GCICCCITTO TOOGOCCCTC CGTCTC UTGOTTITOG GUTTIC ICUTCCICCI TOOGCTCC OCACOCCICI TGGAGGTCG TGGAGG AGCGCUTGG GGGAGCOGCC CGGCCAGCAG GGCAGCCAOG AGCGAOC COAGGCCAG, CATOCUTCCI CCTCGGCTAC

ATGCOGGAG

IGICTOTCT

IGTOGCCIOGC

OCCICICIOC

OCICCTCICC

GTOOCCCI

CIGOGGG

CGGGOCICG

GICUGC!CIG

TGGICCCIO

CIOCUTCICO

UTTGTOGO

GCTCCCOGG

CACTCCAIGG

TCCCGCAGAG GCGGACAGOC GCBCGCCTC TI'GCCBCCTC CTGCGCBGGG CBGCGCCTTG GGGCCBGCGC CGCTCCCGOC GCGGCCBGCB OGGCBGCCBG CBGCGCGCBG CCGBCGOCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG GTCCCOCBGB GGCGGBCBGG C GCTGCCCGGC GGGGTGTGCG CTfOGGCGCTC CCGTGCTCGG TTCTCTGTCT CCCGGTCCCC CTTGCCTGGC GTCTCGGGCC TTCGTCCTCT TCCTCTTCT-r CCTTCCGCTC CGTGGGGGCT GCTTrGGTGGG GGCCTGTGCCT CGGGGTCCCG GGGCUTCTGG CCC~rGCCGT TCATGGTGGC TAGGTGGGGC GTTCBTGGTG GCTBGGTGGG GC GOG GTG GGT BGG CCG TGT CTG GGGGTT GGC CBT G'rr GGT TGC CTCT TGG TOG TGC 0CC GGG CGCG TCT TOG CTT TCT TCT CCT TCG GOC CCT CGG GCC GOT OCT TOT GOCT CCT CCC 000 COG CCT CCC COG OCO GO GCT TCT TOOCO CTO OCO 000 000 CCT CCTGCT CTO TOO CTO GOC OTT CCT TOO TOT TCT 000 TOOTGG CGO OCO TGG TOO CCT CTO TGOOG CCC OCO OCT GCB 000 GTTO CCT OTC TOC TTC OTCCTT TOC OCT CCC 000 CCO CCGGO OTO GOT AGO CCO TOT CTO GGOGTT GOC CAT OTT GOT TOC CGO CCC OCG OCT OCA 000 0 ACAGGOOCTO TAATCTTrCATC

TOCAGOTOOC

TCCTCT-rCAG

TOCBOOTOOC

TCCTCUTCBO

TGYTGTTGCG

GTTCTJ7GTGG

COCOACAGOC

TGCTACCTGC

CBOBTCCOCO

ATOCCAOTGA AATTTAOATC ATCAAAATCC CACATCTGTO GATCTOTAAT ATTTGACATG TTTCAGCAAT GOTTTOATCT AACTOAAOCA CCOGCCAOOB CBGOOGCTOT BBTCTrCBTC BTGCCBOTGB BBTTTBGBTC BTCBBBBTCC CBCBTCTGTO OBTCTOTBBT BTTOGBCBTO TUTCBGCBB TGOTTTGBTC TBBCTGBBOC BCCGGCCBOG TOGCTCOOTO CTTCTOCCCC OCOCTCGT OOTOTOOCCC CTOTGOTGCT TCOITCCCC CTCT-17CTCT TTGT-rCGGOO COGGCTGCTT GTCTCGTTCC OCCCTGTCOG OCGOAAGCC TCTCTCCTCT CCCCAOATC COCAOGCAAO AACCAOCGCA ACCAGGOCOC OTCCOCACAO ACTTOOAOGC GOCTOCATOC TCCAGAAGCO TCCGGTGGCC GCCGGGCC CTOTCOGGCG OOBBOCCTCT CTCCTCTCCC BCBOGCCOCB OOCBBOBBCC BGCOCBBCCB GOGCGCOTCC GCBCBGBCY[r GOBOOCOOCT OCBTOCTGCT BCCTGCTCGGGCG GOBBGCCTCCG OTOOCCGCCO CGCGTCCGGT GOCCOCCOCG CCTCTCTCCT CTCCCCOTOG CCCTOTCOGO COOOTCCTOC COTCCTGTCT CCYTfCTTT TGCTOTCTTG TCTTCCCOTC TCTGCTTT GTCTOTCCTC CCCOTCTCCT CCCACTGCTT CTCCCGGGG CT-rCCCCGOC TTCGGOTOGC COOTOTCCCG GGCTCCGGCG COOCOOCOOC T-TCOGCTOCG GOTGOTOOC GCGGGCTOCC OOGTCCGCOC GGCGCCTOOG CCCTTOTOCT GCT=TGCT TGTTCCGTTC TGGCTOCTCC GOTCTGTGT-[ GTGOTTGTTT TGTITCTTCT TGOTOTOOG CCT-rGCGGT-r TTGGCTGTGG GCCCT-TOOG GCCYITGGCTT CTOOCTCOTC TOTCCTCCCC OTCTCCTCCC ACTGCTTCT CCCGGGGOCT TCCCCOOCTT CGOTOOCCO GTOTCCCOOO CTCCGOCGCG OCGGCGGCTT COOCTOCGO TGOTGGCGC GOOCTOCCOG OTCCGCOCOG COCCTOOOCC CTTOTOCTGC TTTY[TOCTTG TITCCGTTCTG GCTOCTCCGO TCTGTOTFTGT GGT-rGTTTTG TTTCTITCTrG OGTGTGOGCC TTGCGOTT7T GOCTOTGOC CCMIrGOGGC CTTGGCTTCT GGCTCCAT CCACATOATT GCTTAGATTr OTOCTGTATC TCTCAGGATT ATCACTOATT ACACATCCAA CCAOTGCCAO CCAAAAGGAT GCCCTGAGGC AAAGGGT[TC CATCT TGAOO CAAATTTGAG OACBTCCBC BTOBTTGCTT BOBTTTOTGC TGTBTCTCTC BGGBTTBTCB CTGBTTBCBC BTCCBBCCBG TGCCBGCCBB GGTTTCCBTC TTGBGGCBBB MITBGGBGCTBBGBT GBTCCBCBTC

BGBOOTCBCC

TTGGGTTCCG

CGBBGCTBGG

TGGGGCTCBG

TOACCOTOTA

OTTAGTOOAG

AAAGCCCTAC

CGTCCTGTCG

BCBBTOBCCG TGTBOGCBGC TOCCCBBBGO BOOTGliTBOT GGBOBTOTTT GGGGBGBGGT COGTBBBGCC CT13CTBTCTG TBCBCBBCCC OOTCCOGGC TAAOATGATC CACATCACTA GOCAGCTGCC CAAAGUACAA TTTGCCAGGC ATOTTTGGGG AOAOOTCTOA GTCCACCGGO TATCTOTACA CAACCCCCCT CTGCAGCAGA TGGCGCCTGG GOCTCTTCTTr TTGTGGOCTC BCBB3TITCC

CTOBGTCCBC

CCCTCTGCBG

CCACGTTGCC

TGOTTOCACO

AGOACOTTAT

OTCCTOTCGT

YTOOGTGOCT

BBGGBTGCCC TGBOGCBBBO BCTBCCBCGT TOCCCBCCBC BGGCTGO'TTO CBCOBBCTOB CGGGBGGBCG TTBTCCBTT CBGBOTCCTG TCOTGGCGCC CACCACAGAG GTCACCACAA AACTGATTGG OTTFCCGAOOT CCAT[TCGAA GCTAGOCGGT OGCGCCTGGG GCTCAGOGTC OTOOCTGTOG TCTCTOTOOT TGCTGCCCTG OGTCTGGOO TGTGGCCTTG GGGCCGTCCT CTGOCTCCTC CTCGTOGGCC CCC OOTGBCBT-rG BGCBTOTCGO COCGGTCCCG TIBBGBGTGG GCCCGCCAGC CCAGCCACTC CACTI700000 CGOTOOCCA GCACGAACAO CACCCAGAGO AAGGGGGOCG GCCCAGAAGO CGOCCOGAGA TAATOGCAYT CACCACOCOG CGOCCCAGCG TGCAGCCCCC GTCTCCTTGG CATTCCTGGG CCCCAGTCAC GACGOYGGTG BCBTTGBGCB TGTCGGCGCG GTCCCGTTBB TGGGGGCGGG TGGCCAGCAC GAACAGCACC CAGAGGAAGG AGGATCAGGT CTGCTGCGGC CGGAGATAAT GGCATTCACC GGCCCGGGTT CTGACCTGCA GCCCCCGTCT CCTTGGCATT CCCTTGCTGG GGCAGGGACG GCCGTGTTGT CBGTGGTGCT CCCTTTTCTC CTTGrTTTTCC GTTTCTCTTG CCGTCTGTGG TT GCCTACATCO GCATCGAGOT GCTCATCGCC CTGGTCTCTG TGAAGGTOAA CCAGGCOCTG CGATOCCA CCT-rCTGCTT CGTGOTGCC CTGOTCATCC CCCTCGCCAT CCTCATCAAC CTCATGGTTG CCTOTCCGGT CCTCATCCTC ACCCAGAGCT OCAOCCCOCA GGCCAGOATC AOGTCTGCTG

CACOCCOCOC

TCCTCTCCCT

GBGTGGGCCC

GGGGCGGCCC

ACGCGGCGGC

CCTGGGCCCC

GCCCGTTTGB

ATOCCGCCCT

TGCCCGOOAA

CATCGTCTCG

ATI7000CCAC

CCATCCTGGC

ATCCGGCCCG

GCCCCCCT TG

GCCAGCCCAG

AGAAGGGCAG

CCAGCGCACG

AGTCACTCCT

GGTBTGGCGC

CCATCTCAGC

CGTGCTGOTO

CTGGCGGTGO

AOACCTACTT

CCTGCTGGCA

GG1TrCTGACC

CTGGOGCAGG

CCACTCCACT

CCCGCAGGCC

CCGCGCATCC

CTCCCTGCCC

TCCBCCBBTT

T"TTCCAGGCC

ATCTOOOCGG

CTGATGTGGC

CCACACCTGC

ATTGCTGTG

ACCGCTACCT CCGGGTGAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGjACTG CCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTFCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCT[TG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTfGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTTF AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GGGAGCTCTG

GCTGCCGCGC

TGGGCACTGC

GTCTGCTGAT

GCATCGAGGT

CCAGGCGCTG

CTGGTCATCC

CCTGTCCGGT

CCGGGTCAAG

TGCTGGATCC

GGGCCTGGGC

GGAGTACATG

CTGGAGGTCT

AGTACTATGG

GCTGCCTTTG

TACATTGCCA

AGTTCCGCGT

GGATCTCCCA

CCAGCTTTGG TGACCTTGGG GTTGTCCAGA GCCCAGCCCA CTCTGGGACC CCTGCCGGCC GTGCCCAGCC TGTGCCCGCC GCTCATCGCC CTGGTCTCTG CGGGATGCCA CCT-rCTGC'T CCCTCGCCAT CCTCATCAAC CCTCATCCTC ACCCAGAGCT ATCCCTCTCC GOTACAAGAT TCTCCTTCGT GGTGGGACTG AGCCAACGGC AGCATGGGGG GTCTACTTCA ACTTCTTTGT TCTACCTAAT CCGCAAGCAG GAAGGAGCTG AAGATCGCCA CACATCCTCA ACTGCATCAC TCTTCCTCAC GCACGGCAAC CACCTTCCTT AAGATTTGGA GAAGAGAGGC CTGATGACTA GCCCTACGCG CGCGGCCCGG AGCAGGC'AGG ATGGTGCTTG

ATGCCGCCCT

TGCCCGGGAA

CATCGTGTCG

ATTGGGCCAC

CCATCCTGGC

GGTGGTGACC

ACCCCTATGT

AGCCCGTGAT

GTGGGTGCTG

CTCAACAAGA

CCATCTCAGC

CGTGCTGGTG

CTGGCGGTGG

AGACCTACTT

CCTGCTGGCA

CCCCGGAGGG

T-GGCTGGAA

CAAGTGCGAG

CCCCCGCTTC

AGGTGTCGGC

AGCTCTGTTC

CCTCGTGCCC

TTTrCCAGGCC

ATCTGGGCGG

CTGATGTGGC

CCACACCTGC

ATTGCTGTGG

CGGCGGTGGC

CAATCTGAGT

TTCGAGAAGG

TCCTCATGGT

CTCCTCCGGC

CCTGGAACT7

CTTGGTGCCC

GCCTACATCG

TGAAGGTGAA

CGTGGGTGCC

CTCATGGI1TG

ACCGCTACCT

CATAGCCGGC

GCGGTGGAGC

TCATCAGCAT

CCTCATCTAC

GACCCGCAGA

AGTCGCTGGC CCTCATCCTC T-fCCTCTTTG CCCTCAGCTG CCTCYI'CTGC CCGTCCTGCC TCGGCCATGA ACCCCAFTGT ATGACCATTT CCGCTGCCAG GACCCCGCCT TCCGCTCCCA TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCT[G GGAGTCTGCT TGTCTTrAGAT G7I17GGTGGTG CAGCCCCAGG ACCAAGCTTA ACAAGCCCAG CATCCTTACC CTATGCCTTC CGCATCCAGA CCTGCACCTC CCATTGACGA CCAGCCCACA TCCAGTGGGG GCCCCAGCTG GGCTGTTGGC CACTAGGAGT TAACTACCCT GACCAGGTGT CTAGAGGCAA 'TCAGGGCTG GGCAGGTCCT GGCTTCTGCG GTGAGGCAGG AGGAGAGGAG AGCATCTGCT

CTGAGACGGA

GCTAAGGGGC

GCTAGGGTGC

TCAGTAATCA

GTGCTGGCCT

AGCCTGGAGT

CCTAGGTGAC

TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA Y[GTACGTGG GAGAGGCAGA AAGGGTAGGT T-rTCTGATGA 1TGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTJTCTTG CCCTGAGCTT TCCGGOGAGG GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGUTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGJAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCT'rr GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACMIIAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGYrG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTI'G ACCYJ7CTGAA CATGAGTGTC AACTCCAGGA cT-rGcT-'CCA AGCCCT-rCCC TCTGTTGGAA ATfl7GGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT CGCATT-rGTG TTFAATAAA AGAATCTGGA AGATAAATAG TCT1'GAAGAG AGACAAAGGA AGGAAAATI' AAATCCTTAG AT-TCAAGCAG AAGAATTCCA TGTGGAAGOT TTGGGTTGTT GTTGTTGTTG TTTGGTGTGT TIrTTTGTTT TTTGT-M=T TGTTrn-r TGAGATGGAG TCTCGCTGTG ITACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCT-rG GC1TCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTI GGTGCCCGTC TGCTGATGTG 37 CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACAYI7 GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGGCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTFCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTrGCCC TCAGCTGGCT GCCTrGCAC ATCCTCAACT GCATCACCCT C'I17CTGCCCG TCCTGCCACA AGCCCAGCAT CCTTrACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CT-rCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA I17GACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC

CCCCTCGCCC

CAGGACGCGC

GCGCCGCGGT

CGACGTGGCC

TACGGCTGCC

TGGCAGTCGA

AAGAGGGGTC

AGTAAAGACA

TGAAGTGTCT

GCCCCCACTG

ACTGAGCTGA

TTGTGGGGAT

TCAGGGTAAA

AATCCCATTG

T-rCTCTGCCA

ATGATCTAGG

TTrCAT[GTGA

CACGTATCTA

AGCTGC1Tr TCTGCCTI7GT AATACTT1TTT

GAAGGTGACC

ACTTI'GGGAG

GGGCAAMIG

GCGCGAACTT

TGGGTGCCGC

CTCAGAAGCG

CTCGCCCGGC

GACGCGCTGT

CCGCGGTGGG

CGTGGCCGTG

GGCTGCCTCT

CAGTCGACAG

AGGGGTCATU

GGCGCGCCTTr CGGTAGGGGG TGTACGTGGC GCTGGAGCTG GGGCACGGCG AACACTCTGC CGCCCGGGGC CCAGCTGGCC GTCATCGCCG CGCTTTCGGT AGACGCCCAC CAACTACTTC

GTGGGGCTCT

TCTTCCTCGC

CAGATACCTG

ATTGCTGTCC

GTGCCACCAA

CTTTGAGAAT

C'FrATAATGC

TGGACCACTC

1TTGCCCTG

AATAAGCCCA

TCTATGCTTA

AGCAGATGTC

CTCTCGCCTC

AAGATAGCTA

GCTAATATGT

ACTGTGTGGA

TTATGGTGGA

AACTTAGAGG

TCAAAAATTA

TCGCCATCCC CYITGCCATC ACCATCAGCC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC GCCATCTGTG TCCCGCTCAG GTATAAAAGT TCTGGGTCCT TGCCYJ7TGGC ATCGGATTrGA CAACTGCACA GAACCCTGGG ATGGAACCAC GTGGTCCCCA TGAGCTACAT GGTATATTTC TGGTGATCTA CATTAAGATC 'ITCCTGGTGG GAGGACCACC CTCCAGCGGG AGATCCATGC TGCTGGTTAC CTGTGCATGC TGTTAACTGT AGTGGGCAAT GAATATGGCC ATTCTTCTGT CCGGAACCGA GACTTCCGCT ACAC'TTTTCA AAGAGTGGGA ATGGTCAGGC TGGGGTACAG TTCCAGGAGA AGATACAAAT CCACAAGAAA CACCTCACAA GGAAATGGAC TGCCTCTCTT ATGTGTCAGT AGTAGCACCA AGGATTGACA TrATGCCAAC AGCTTGAATG GATTCTAACA AAATTACTGA AACTAYI17TA CTGTGAAACA CAATGOAAAA ATAAAAGTTG ACTGTACTAA AAAGTATAAT TATTCGGCCG GGCATGGTGG CGGCGGGTCT CACGCGGCTG CGGCCATGCT GCTGGAGACA GGCGGGCAAC GTGCTGGTGT CTGGTGTCCC TGGCTGCGGC TGGGCTTCTG CACTGACTTC CATCTTCAGC CTTJCTGGCCG 17GGTCACGG GGACCCGAGC CTCCATTCCT GGGGTGGAAC GAATGAAAGC TGCTGCCTTG AATTTC117TG GGTGTGTTCT CCTGCAGGCA GCTTCAGCGC AGCCAAGTCA CTGGCCATGA GTCACTCTTT TCCAGCCAGC CACATGCCAA YrCAGTTGTC CAAAATTATC TCCAGGTATC CCTGCTCTCG GTGTGGGCCT CAAAGAGGAC ACGGCTGGTT GAGCACTTCC CTGGAGCTAC AATATATTTA TGATCTATTC GACTCTTTTrG TTTTAAAAG GTGTGAACTA TTATAATGCA AAATGTATAC TTGTTGCCAG CTCACACCTG TAATTCCAGC GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG TTAGITATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG TGOGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA CTCTrGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC GCGCCUTCGG TAGOGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GOAGACACAG ACGTGGCOCT GGAGCTGGTC ATCGCCGCGC 'ITCGGTGGC GGGCAACGTG CTGGTGTGCG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTrCCTG GTGTCCCTGG CTGCGGCCGA GGGCTCTrrCG CCATCCCCTr TGCCATCACC ATCAGCCTGG GC11TCTGCAC TGACTTCTAC TCCTCGCCTG CTTCGTGCTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTTr CTGGCCGTGG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG GCTGTCCTCT GGGTCCTrGC CTTTGGCATC GGAY7GACTC CATTCCTGGG GTGGAACAGT 38 AAAGACAGTG CCACCAACAA CTGCACAGAA. CCCTGGGATG GAACCACGAA TGAAAGCTGC AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTrTCAAT TTCTTTGGGT CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC TGGGGATTTT TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC CCCATTGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CYIICACAA TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA CTGCTTTTAC TGTGTGGAT1' ATGCCAACAG CTTGAATGGA TTCTAACAGA

CAAGTCACTG

ACTCTTrCC

ATGCCAATTC

AATTATCTCC

GCTCTCGGTG

AGAGGACACO

CACTTCCCTG

TATATTrATG

CTCTTTTGTT

TGCCTTGTGA

GTGTTCTGCC

TCAGCGCACT

GCCATGATTG

AGCCAGCTCA

AGTTGTCAAT

AGGTATCTTC

TGGGCCTATG

GCTGGT1TC

GAGCTACCAC

ATCTATTCAG

TTfAAAAGTC TGCCTTGTTT ATGGTGGAAA ATTACTGAAA CTATTITACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG GAATrCCCAG ATGCAGAG

GTGGCTGGGC

TATCTTGCCT

GACTGATTCC

GG'FrCAAAGA

TCCTAGAAAT

TTrATGAGGGA

ACATTGGAAA

GCTCAGGGAG

TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TTCTCTCTAG TGGGTTATTC TTTCATGTGG ACAGCATGCT GTGTTrGGAC ACAAACCCCT T7CCTTGGTT TCTCTGACCC AGCTGAGATG AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TFTTGCAGT ATrTAACTAA GTGCTATATA GTGAGAAAGG CTTCTTFTT 3TITT-TTTT TTTTTTGGCA GAGTGCTGCC TTCTCTTGGT AACTTCCTrC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT CACATTGGAG GCCGATGAAG CTTTFCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT TIIAATGTC TGGGGAGTCT AAATGACAAG TCTGGCGGGG ACAAGTATGG GATITGGTAA GAC'rrGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA TGTrrGTr ACT GCTGAATTTT ATrTTGGGCT GTACATATTTr CAAGCCACTG TGTGGGTTTG GGTCCAAGTG 'FrCCTTC'rrG TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTCAGGGA TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GTITCTTTCC CTI1CTTTCTG TATGTCTGGT CATTCTGCTA GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTAGG GAGCAGATCA ACTAACAAGA AGTGTTTrGTT AGTAAACACC AGATGCT7AA GGTAAAAATG CTGCCTCTCT AACACGCCTG TCCCCAAATA ACAATGGCGT GAGGGGGCTG ATTCCCAGAC GAGGATATGC CATTrGATTC TTCTGTCGTT CCTCACATAG TGTGAGCTGA GAAAGAGAGG

GCAGGTGTGA

GACCAAGGAT

TAGCAGGAAT

CGTTTGCCTC

TGCT'rCTCAG AGGTGCTGAG 1TTTGCCCT TCTGAGCAGG GAATCTTTGC C1TTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG AGT-rCTGGCT AAGGTFIAGGA GGCTGCCACC AAAGTCTCTT TTTGTTCCT CTTATCATGA GATCTTMTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA GAGCCTTCTC TATGCCACTC ATGGCTCCTC T-rCTGCTCT-r GTACTTCCTC T-rGGCCCATC TCACTTCCTG AAACACCCCT AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT AGATTCAGTC CATATAGAGC GGAAGTGACC CACCTGTGAT GGTAGGAATG AGCAAGTTGG AGCTAGOCCC ACTGGCCCTA GCAAGATGCC CAACAACAGC TGGACTCTGC GCCATAGTGG ACCACCTTCT ATTTCATTGT CCATTGT'TGT CAGCCTGGGC CTTTACCCAC GCCTCCATCA TGTCCTACAG CA'rrCTGGAA GAGCCC1TC TAAGGAGAAG GAATTAGA CTGTCACTGC GAGACGGATC T-rGCTGGCTC ACTGCTCTGT CA~rGGCCAA GCAACGTGCT GGTCATCTGC CTCTCTAGCC CTGGCTGACA ATCACAATCC ACTrCTACAG TGTCCTYrGCT GGCCATCGCT TGAATGAACT CTGATACCCA TCCATCTTTT TGCTGAGAGT GAAGAGGGTT GCTTATCTTG GITr1GGGGAA CTAAGAGCAG ACITGAGGAT GTGCGGTGCA GG'IMCCAAG AGATCACCCC ACATGGACCT CTGGGAAGAC ACCTGTCCCT GTGGAGGTTC TGTrACCTAC ATCACCATGG GTGGTCAAGC TGAACCCCAG TTGCTGTI'GG GGTGCTGGTC CTGCCTT1T ATGACTTGCC GTGGACCGAT ACTTGCGGGT AGCTGGGAAA TGAGGCTACA.

AAGGTAAAAA TGATAAAGCC TAACACGjCCT GGTrAAAATA AACTATGGCG TGCAAGTGTC

GGACCCTGAT

AGAACGCCAT

ATAAAGCCCT

GTTAAAATAA

GCAAGTGTCT

AGTCGCCTGT

TGTTGCACAC

GTTGGACATT

TGGAGGCTAA

TTrATCCCMT

TGCAAGAACT

CTGCTTCTCC

GCTTCCAGCT

ATCTTGTCTC

TCTGAGCTCT

ATGGAACTCA

CAGCACTrC

TAAAGGGGCT

ACCAGAAAAG

GTCTGGCGAG

CCCTGGGAAG

AAAT1TCAT

CCTGCAGACC

ATGCCT[GG

TACTGCTTAT

CAAGCTTACC

AAGCCAGAGC

CTCAAGCCAC

ATCCCT1GG

TGGTTCCCAG

GTCAGGTAGC

CTGCTGAATTF

TGTGTGGGTTF

ATGGTGCTGA

CTGCGGCGTG GGGTGGGCAG CAArrGAGGC TTATTIGGA CTGTACATAT TTAGATGCTT GGGTCCAAGT GTTCCT7GCT GCTGCCTCTC GAAGCACCTG AACCAAGTGG GTCCCCAAAT AAGTTrGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA 11'CCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCT-rGGGGAA TGTGGGCAGG AGGATATGCC A1T~GA1TCT GTI'GCACACG TTCTTTTCCC Trc1TrCTGT ATGTCTGGTC AT-rCTGCTAT TCTGTCGTTC CTCACATAGG TrGGACATrG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT MTGCTAGGG TGTGAGCTGA GAAAGAGAGO TGGAGGCTAA GCAGGTGTGA TGC1TCTCAG AGGTGCTGAG 1TT=GCCCT TCTGAGCAGG GAATCYTGC TTATCCCT GACCAAGGAT CTrTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTG1TCCT CTGCTTCTCC CGTTTGCCTC CYUATCATGA GATCTTTTrG CTAAGCTGGC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TATGCCACTC ATGGCTCCTC YJ7CTGCTCT-F CTI7GGCCCAT CTCACTTCCT GAAACACCCC AAAGCTGCAG GCAGAGGCGT TGAGGACATC CCATATAGAG CTGTCCTACA GCATCTGGA CCACCTGTGA TGAGCCCTT[ CTAAGGAGAA GAGCAAGTTG GGAATTTTAG ACTGTCACTG CACTGGCCCT ACAGACGGAT CT-rGCTGGCT

AGAAAGATTG

TGAATGAACT

TCCATCTTTT

TGAAGAGGGT

TGTTTGGGGA

AACTTGAGGA

GGGTTTCCAA

CACATGGACC

CACCTGTCCC

CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATACCCA ATCTTGTCTC GAGCCTTCTC TGCTGAGAGT TACTGAGCTC TGTACU7CCT TGCTTATCTT GATGGAACTC AAAAAGCCAA ACTAAGAGCA GCAGCACTTr CAGATTCAGT TGjTGCGGTGC ATAAAGGGGC TGGAAGTGAC GAGATCACCC CACCAGAAAA GGGTAGGAAT TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCTrTCTA AGGAGAAGGG fl'TCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTfCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC CACCTrCTAT YJTCATTGTCT ATTGTTGTCA GCCTGGGCAT TTACCCACGC CTCCATCATG CAGATACAAG AGGGTCACCA CTGGTGGGAT TGACCCCCAT TCCTTTCATG CCAATTTGTT T-rTCATCCCC CTGGTTGTCA CTGAACTTAT CTAACTCCAA TFTCTGGTTCT TTTCTrrGrT TGGTGAGGTA CCACAGCTTG ATCGTCTATG CCTATAAAAT GCCATCCCTC TGATTCTTTG TGTCTCATTG ACCTI7CAGAT TACATCCTTG ATTACTI7CCA CTACTCTCTT CCTCCACTrFC GGGGACAACG TATTATTGAT GAAGGGTGCC TAGTTGACTT AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC CTCTAGCCCT GGCTGACA'IT GCTGTTGGGG TGCTGGTCAT CACAATCCAC TCTACAGCT GCCTTTTTAT GACTTGCCTA TCCT-fGCTGG CCATCGCTGT GGACCGATAC TTGCGGGTCA CTCACAGAAG AATATGGCTG GCCCTGGGCC 1TTGCTGGCT

GTTTGGCTGG

TCCGTCATGA

TGTGCGCCAT

AGAGACAGGT

GCTCTGTCAT

TGCTGTACAT

AAAGAAGTTC

GACACAAGCA

TCCCCATCAA

CTGAGGTGGG

A317TTTCCTT

ATTATTGTCT

AACATGAAAC

GGATGGACTA

CTATCTTGAC

GCATT'ITATG

GGCTGCC1T

GGGCATCCTG

AAGGAAACCT

TTGAGJAAGAA

TGACCTCAGA

CATGGTATAC

ATCYFTTACA

GACGGGAGTI'

ATCTCTCATC

CTGTCCCATG

ACCTITTGAT

TTCTGAGTAG

OTACCACAGA

TTCAGiCTTCC

TCATTCGGAA

CAAGACGGCT

AACTGCATCA

CCAACTCCAT

CCTCAAAGCC

TTATCCATCA

TGCCTGGGCC

AT7ATATCTC

GTGTTTTGGA

AAGAATAAGT

TGCAGACCAC

GCCTTTGGCC

CTGCTTATCT

AGCTTACCGT

GGTGTCATTC

AATGTCACCT

TCACCTGGAT

CAAACTCAGT

AAGTCCTTGT

TCTACTTTAA

GATGAACCCT

TGTGTGGTCT

GAGATGACTC

AAGGGATTTT

CCCCACTCCA

GGCCTGACTT

CATGGAGCCT

CAAACACTTG AGGGCCTGTA AGCATCTCCA GTGCTCCCCA TGTCCTTTCT CTCTAATTCA GTTTTCCTTC ITCCCAATAG ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TFTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGYITAAGG GGGACTTAAA CTGCTGAATT C CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA 'ITGAGGGACA GTTGCTT117C AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA AT1IGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATI1ACTGT TC'FI7ATTTGC TGCCACACCT GAGCCAGCCT

GCTCCTTCCC

TCCGTCCCTG

AGTGCACAAG

GCAT-rAATAA

CACTGATGGA

CAGTAITGAG

CTCAAGTGGG

TGGGTGATAT

AGGAGTGGAG

CCCCAGCAAG

TGAGTTGTTG

AGGTTAAGCC

CAAGGAGGTC

CACTGTAGGC

AACGACTGGG

GGACAGCAGA

GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC ACAACflAGA TCTCCAGGAG AACTGCCATC CAGC1TTGGT GCAATGGCTG CCCTGGGTr CTrrAATCTA TTCAGCTAGA ACTTTGAAGG ACAATrCTT CTGAGGG4JTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG AGGGGAGAC CAAGGTTCCA (3CTCAACCAA TAACTA'ITGC ACAACCACCT GTCCCTGCCT CAGTTCCCTrF TTATGTAACA TGAAGTCGTTr GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATrACGCA GACGTAACTG GGATATGTr- ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GOCACACAGT AGGTGCTCAT TGGCTCCC1T CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCAT[GGAG AGAAGGCCAT GTCTTCAAAG TCTGATGT GATGAGGCAG AGGAAGATAT TCTAATCGG TCTI'GCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTFCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT Y-rATTGGAAG GTGOCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGT7A GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTdGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTrACC CCCAACCCAC TCT117TTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGOC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TJ7AGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTC TGTAGAGCAT AATAAATGGA TGAGGTT17 GCAAAAAAAA AAAAAAAAA ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CC17CTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTFGGGCCAC AGACCTACT[ CCACACCTGC CTCATGGT7G CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTFGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTrCGT GGTGGGACTG ACCCCTATGT UTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TrCGAGALGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTITTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TI1CCTCTTTG CCCTCAGCTG GCTGCC'ITTG CACATCCTCA ACTGCATCAC CCTC'TCTGC CCGTCCTGCC ACAAGCCCAG CATCC'rrACC TACATTOCCA TCTI7CCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCYFC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTI7GGA ATGACCATT7 CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGGGCACTrG CACTGGAAGG

TCAGGCAGCC

AGGACTATGA

CCTGGAACTT

CTrGGTGCCC

GCCTACATCG

TGAAGGTGAA

CGTGGGTGCC

CTCATGGTTrG

ACCGCTACCT

CATAGCCGGC

GCGGTGGAGC

TCATCAGCAT

CCTCATCTAC

GACCCGCAGA

CCCTCAGCTG

CATCCTTACC

CGCATCCAGA

CCATTGACGA

TCCAGTGGGG

GGCTGTTfGGC

AATCCCTGGA

GGGAGCTCTG

GCTGCCGCGC

TGGGCACTGC

GTCTGCTGAT

GCATCGAGGT

CCAGGCGCTG

CTGGTCATCC

CCTGTCCGGT

CCGGGTCAAG

TGCTGGATCC

GGGCCTGGGC

GGAGTACATG

CTGGAGGTCT

AGTACTATGG

GCTGCC'FrTG TACATrGCCA

AGTITCCGCGT

GGATCTCCCA

TCTCAGTCCA

TGGGGGCATG

GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG CCAGCT[GG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG CGGGATGCCA CCTI7CTGCTT CATCGTGTCG CTGGCGGTGG CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACUT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG TCTCCTJTCGT GGTGGGACTG ACCCCTATGT 'FrGGCTGGAA AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG GTCTACTTCA AC'rCTrrGT GTGGGTGCTG CCCCCGCrrTC TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCA1TGT CACCTTCC11' AAGA'rrrGGA ATGACCATr CCGCTGCCAG GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA GTCCTCACAT GCCCGCTGTC CCAG7GGGTCT CCCTGAGCCT GOGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG

GGTTTAACCT

GACAGAACAG

CGGGAGCCGG

AGCTCTGTTC

CCTCGTGCCC

'TTCCAGGCC

ATCTGGGCGG

CTGATGTGGC

CCACACCTGC

ATTG3CTGTGG

CGGCGGTGGC

CAATCTGAGT

1TCGAGAAGG

TCCTCATGGT

CTCCTCCGGC

TTCCTCTG

ACAAGCCCAG

CTATGCCTTC

CCTGCACCTC

CCAGCCCACA

GCCCCAGCTG

CACTAGGAGT

GACCAGGTGT

TI'CAGGGCTG

GIJCTTCTGCG

TAACTACCCT ACACCTCTGG CTAGAGGCAA CAGTGTTCTG GGCAGGTCCT GGGGAGGCTG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGOAG .41 AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA 11TTCTGATGA TYUFGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCT-r GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCT-rCT-rG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCGC CGTTrGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGT-rGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTFFGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTrFTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTUCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTGCA AGCCCTTCCC TCTGTTGGAA AT-rGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC

TGTGAACCCT

AGGAAAATTT

TTrTGGTGTGT

CGACAGAGCC

GC11TCCCCAG

GTCAGGCAGC

TGCTGATGTG

TCGAGGTGCT

GGCGCTGCGG

GTCATCCCCC

GTCCGGTCCT

GGTCAAGATC

TGGATCCTCT

CCTGGGCAGC

GTACATGGTC

GAGGTCTTCT

ACTATGGGAA

GCCTTTGCAC

ATTGCCATCT

TCCGCGTCAC

CGCATT-7GTG MTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AAATCCUTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT 'ITGGGTTGTT TTTYJ7GTTT-r TT-rGTTTTTIT TGTTTTIT TGAGATGGAG TCTCGCTGTG GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT CGGGAGCTCT GCCAGCTTTG GTGACCTGG GTGCTTGCCT CGTGCCCCTU CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTY[ CCAGGCCGCC CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT TCGCCATCCT CATCAACAY[ GGGCCACAGA CCTACTTCCA CACCTGCCTC CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC CCTCTCCGOT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT CCTTCGTGGT GGGACTGACC CCTATGYT-G GCTGGAACAA TCTGAGTGCG CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TACTI1CAACT TCTTI7GTGTG GGTGCTGCCC CCGCYI7CTCC TCATGGTCCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC ATCCTCAACT GCATCACCCT CTTrCTGCCCG TCCTGCCACA AGCCCAGCAT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC CTTCC'rrAAG AT-rTGGAATG ACCATrTCCG CTGCCAGCCT GCACCTCCCA

AGACAAAGGA

GTTG'I17GTTG

TTACCGGGAG

GCCGGCCTTG

GGACAGAACA

GGTGCCCGTC

TACATCGGCA

AGGTGAACCA

GGGTGCCCTG

ATGGTTGCCT

GCTACCTCCG

AGCCGGCTGC

GTGGAGCGGG

TCAGCATGGA

CATCTACCTG

CCGCAGAAGT

TCAGCTGGCT

CCTTACCTAC

ATCCAGAAGT

Y[GACGAGGA

TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCT-rCC GCTCCCACCG AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGOTCCTA CGGAGGGACC GTTCTGAG;CC CCCACCTGCC TGACCATCCC ATGAGjCAGTC CAGAGCTTCA AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCT-rGGGCT TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA CCCACATCCA GTGGGGTCTC CAGCTGGGCT GTTGGCTGGG AGGAGTTAAC TACCCTACAC AGGTGTCTAG AGGCAACAGT GGGCTGGGCA GGTCCTGGGG TCTGCGGTGA GGCAGGGGAG GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CCCCTCGCCC GGCGCGccT-r CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CAGGACGCGC TGTACGTGGC GCGCCGCGGT GGGCACGGCG CGACGTGGCC GTGGGGCTCT TACGOCTGCC TCITCCTCGC TGGCAGTCGA CAGATACCTG AAGAGGGGTC ATTGCTGTCC AGTAAAGACA GTGCCACCAA TGAAGTGTCT CTTrGAGAAT GCCCCCACTG CTTATAATGC ACTGAGCTGA TGGACCACTC TTrGTGGGGAT TT~GCCCTG

GCTGGAGCTG

AACACTCTGC

TCGCCATCCC

CTGCTTCGTG

GCCATCTGTG

TCTGGGTCCT

CAACTGCACA

GTGGTCCCCA

TGGTGATCTA

GAGGACCACC

TGCTGGTTAC

GTCATCGCCG CGCTTTCGGT AGACGCCCAC CAACTACTTC

CTTGCCATC

CTGGTGCTCA

TCCCGCTCAG

TGCC1T'GGC

GAACCCTGGG

TGAGCTACAT

CATTAAGATC

CTCCAGCGGG

CTGTGCATGC

ACCATCAGCC

CGCAGAGCTC

GTATAAAAGT

ATCGGATTGA

ATGGAACCAC

GGTATATC

TrCCTGGTGG

AGATCCATGC

TGY[AACTGT

CGGCGGGTCT

CGGCCATGCT

GGCGGGCAAC

CTGGTGTCCC

TGGGCTTrCTG

CATCTTCAGC

TTGGTCACGG

CTCCATTCCT

GAATGAAAGC

AATTTCTTTG

CCTGCAGGCA

AGCCAAGTCA

GTCACTCTrF

CACGCGGCTG

GCTGGAGACA

GTGCTGGTGT

TGGCTGCGGC

CACTGACTTC

CTfTCTGGCCG

GGACCCGAGC

GGGGTGGAAC

TGCTGCCTTG

GGTGTGTTCT

GCTTCAGCGC

CTGGCCATGA

TCCAGCCAGC

TrCAGTTGTC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA 42 AATCCCATTG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACACTTFTCA CAAAATTATC TCCAGGTATC TTFCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGOGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCAC'FrCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGAUTGACA AATATATTTrA TGATCTATTC AGCTGCT1TT1 ACTGTGTGGA TTATGCCAAC AGCTTGAATG GATTCTAACA GACTCTTTrG TITIAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA AACTATTrTA CTGTGAAACA GTGTGAACTA TrFATAATGCA AATACTTTT-r AACTTAGAGG CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TrGTTGCCAG GAAGGTGACC TCAAAAATTA AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG YFCAAAACCA GCCTGTCCAA TATAGTG GGGCAATYFG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTIGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CGTGGCCGTG GOGCTCTTCG CCATCCCCT-r TOCCATCACC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA AGGGGTCAT[ GCTGTCCTCT GGGTCCTUGC CTTTGGCATC AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTrC GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TGGGGATTTr TGCCCTGTGC TGGTTACCTG TGCATGCTGT GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCA1T CCCATTGTCT ATGCTTACCG GAACCGAGAC TI7CCGCTACA TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG

OCTGGCCCGG

1TTCGGTGGC

CTACTTCCTG

ATCAGCCTGG

AGAGCTCCAT

TAAAAGTTTG

GGATTGACTC

GAACCACGAA

ATATI1CAAT

CTGGTGGCCT

TCGATGCAGC

TAACTGTGTC

CTTCTGTCAC

CI=rCACAA

GGTACAGCCT

CCATGCTGCT

GGGCAACGTG

GTGTCCCTGG

GCTTCTGCAC

CTTGAGCCTT

GTCACGGGGA

CATTCCTGGG

TGAAAGCTGC

TTCTF[GGGT

GCAGGCAGCT

CAAGTCACTG

ACTCT1TITCC

ATGCCAATTFC

AATTATCTCC

GCTCTCGGTG

AGAGGACACG

CACTTCCCTG

TATATTTATG

CTC3TTTGTT

GGAGACACAG

CTGGTGTGCG

CTGCGGCCGA

TGACTTCTAC

CTGGCCGTGG

CCCGAGCAAG

GTGGAACAGT

TGCCTTGTGA

GTGTTrCTGCC

TCAGCGCACT

GCCATGATTG

AGCCAGCTCA

AG'FI7GTCAAT

AGGTATCTTC

TGGGCCTATG

GCTCYGTrTC

GAGCTACCAC

ATCTATTCAG

TTITAAAAGTC

ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA CTGCTrTTAC TGTGTGGATT ATGCCAACAG CTrGAATGGA TTCTAACAGA TGCCTrGT' ATGGTGGAAA ATrACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTITTTAA CTTAGAGGCA ATGGAAAAAT AAAAG'FrGAC TGTACTAAAA ATG GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TTCTCTCTAG TGGGTTATTrC TATCTTGCCT ACAGCATGCT GTGTrTGGAC ACAAACCCCT TTCCT7GGTT TCTCTGACCC GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT T1TITGCAGT GGTTCAAAGA GTGCTATATA GTGAGAAAGG CTTCTTTIT 'TTI=r1T TTITMGGCA TCCTAGAAAT TTCTC'rrGGT AACTrCCTrC TCTGAAGCAC AGATAAAGAA AACAATTACA TTATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGOAGA GGACTGCCCT 'rITfAATGTC GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GAGCCCCAGG CAGAGGCGTC TcccT-rATGC CCCACTCTGA AGTGT-17GT-F AGTAAACACC TG'I1GTTACT GCTGAATT ATTGGGCT GTACATATr AGATGCTTAA GGTAAAAATG CAAGCCACTG TGTGGGTrTG GGTCCAAGTG TTCCTTC17G CTGCCTCTCT AACACGCCTG TCCCTrrGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GGTTCCCAGA AGT-FGGTGAC TAGGTAAGCA GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC 1TCATGTGG

AGCTGAGATG

A'TTTAACTAA

GAGTGCTGCC

GTAGAAACAT

GGCAGAACTG

TGGGGAGTCT

AACTTGGGAT

GGACCCTGAT

AGAACGCCAT

ATAAAGCCCT

GTTAAAATAA

GCAAGTGTCT

AGTCGCCTGT

TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTrGATTC TGTTGCACAC GTTCTTTrCC CTrCTTTCTG TATGTCTGGT CATTCTGCTA T-rCTGTCGT CCTCACATAG GTrGGACATr GGCCGGCTGC CAGCATAAGT GCCAGTGTGA T1TGCTAGG TGTGAGCTGA GAAAGAGAGO TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG 1TITGCCCT TCTGAGCAGG GAATCTTTGC 'VrATCCCTr GACCAAGGAT C1TrGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGT-rcTGGCT AAGGTTrAGGA GGCTGCCACC AAAGTCTCTT TrTGT-rCCT CTGCTCTCC CGTrITGCCTC CTUATCATGA GATCTT1TG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTrGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC YUCTGCTC1T TCCATCTT GTACTTCCTC T-rGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT G1TTGGGGAA AGATTCAGTC CATATAGAGC TGTCCTACAG CA17CTGGAA ACYFGAGGAT GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG GGMrCCAAG GGTAGGAATG AGCAAGYI'GG GAATTTTAGA CTGTCACTGC ACATGGACCT AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTrACCTAC TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC ACCACCTTCT ATTTCATTGT CTCTCTAGCC CTGGCTGACA TTGCTGTTGG CCATTGTTGT CAGCCTGGGC ATCACAATCC ACTrCTACAG CTGCCTT

CT"TTACCCAC

GTCAGGTAGC

CTGCTGAATT

GCCTCCATCA TGTCCTFGCT CTGCGGCGTG GGGTGGGCAG TTATTTTGGA CTGTACATAT GGCCATCGCT GTGGACCGAT CAATTGAGGC AGCTGGGAAA TTAGATGCTT AAGGTAAAAA TGCTGAGAGT TCTGAGCTCT GCTI'ATCTTG ATGGAACTCA CTAAGAGCAG CAGCACTI7TC GTGCGGTGCA TAAAGGGGCT AGATCACCCC ACCAGAAAAG CTGGGAAGAC GTCTGGCGAG GTGGAGGTTC CCCTGGGAAG ATCACCATGG AAATTTTCAT TGAACCCCAG CCTGCAGACC GGTGCTGGTC ATGCCrGG ATGACTTGCC TACTGCTTAT ACTTGCGGGT CAAGC'ITACC FGAGGCTACA AAGCCAGAGCS TGATAAAGCC CTCAAGCCAC GGTTAAAATA ATCCCTTTGG TGCAAGTGTC TGGTTCCCAG GTCGCCTGTT CCTGCTGGGA GTTGCACACG TTCT1TCCC TTGGACATTG GCCGGCTGCC TGGAGGCTAA GCAGGTGTGA TTATCCCTTT GACCAAGGAT TGCAAGAACT TAGCAGGAAT CTGCTTCTCC CGTITTGCCTC GCTTCCAGCT CCGCTCCCAC ATC'ITGTCTC GAGCCTTCTC TACTGAGCTC TGTACTUCCT 3ATGGAACTC AAAAAGCCAA GCAGCACT CAGATTCAGT TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG AAGTUrGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA -17CCCAGACA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATITGATTCT T'C'TTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGAGCTGA GAAAGAGAGG TGCTTCTCAG AGGTGCTGAG 1TI1GCCCT TCTGAGCAGG GAATCTTITGC C1TTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG AGUTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TITTTGTTCCT CTTATCATGA GATCTTTTFG CTAAGCTGGC AGAAAGATI'G CATAATCAGT CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA TATGCCACTC ATGGCTCCTC TITCTGCTCTT TCCATCYTT TGCTGAGAGT CTTGGCCCAT CTCACYUCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA ACTAAGAGCA CCATATAGAG CTGTCCTACA GCATJTCTGGA AACTTGAGGA TGTGCGGTGC CCAGCTGTGA TGAGCCCTTT CTAAGGAGAA GGGTTTCCAA GAGATCACCC GAGCAAGTTG GGAAT1TTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGTT4 CCAACAACAG CACTGCTCTG CGAATTCGGG GGACATCTGT TTGGGGAACT ATTCAGTCCA TATAGAGCTG TCCTACAGCA TI7CTGGAAAC TTGAGGATGT AAGTGACCCA CCTGTGATGA GCCCYIrTCTA AGGAGAAGGG TTTCCAAGAG TAGGAATGAG CAAGTTGGGA ATT=AGACT GTCACTGCAC ATGGACCTCT( CTAGGCCCAC TGGCCCTACA GACGGATCTF GCTGGCTCAC CTGTCCCTGT AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TI7ACCTACAT GACTCTGCOC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG CACCFCTAT TTCATTGTCT CTCTAGCCCT GGCTGACAIT GCTGTTGGGG ATTGTTGTCA GCCTGGGCAT CACAATCCAC 1TCTACAGCT GCC1TTUAT 1TACCCACGC CTCCATCATG TCCTIGCTGG CCATCGCTGT GGACCGATAC CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAGA TccTF-rCATG CCAATTTGT-r TCCGTCATGA GGATGGACTA CATGGTATAC 1TITCATCCCC CTGGTTFGTCA TGTGCGCCAT CTATCTTGAC ATCT=TACA CTGAACTTAT CTAACTCCAA AGAGACAGOT GCAlTIATG GACGGGAGTT 1TCTGGTTCT T-17CTTGTrrT GCTCTGTCAT GGCTGCC1TU ATCTCTCATC TGGTGAGGTA CCACAGCTI7G TGCTGTACAT GGGCATCCTG CTGTCCCATG ATCGTCTATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACC=r~GAT OCCATCCCTC TGATJ7CTTTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TGTCTCATTG ACCTJTCAGAT TCCCCATCAA CAAACACT7G AGGCCTGTA TACATCCTTG ATITACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA CTACTCTCTT CCTCCACYUC A1T=TCCTr TGTCCTTTCT CTCTAATUCA GGGGACAACG TATTATTrGAT ATTATTrGTCT GT=TUCTTC TCCCAATAG GAAGGGTGCC TAGTI'GACTT ACTGACAAAA GGCTCTAGIT GGGCTGAACA

ALTAAAGGGGC

CACCAGAAAA

CGTCTGGCGA

CCCCTGGGAA

AAGAGCAGCA

GCGGTGCATA

A.TCACCCCAC

3GGAAGACOT

GGAGGTTCCC

CACCATGGAA

AACCCCAGCC

TGCTGGTCAT

GACTTGCCTA

TTGCGGGTCA

TGGAAGTGAC

GGGTAGGAAT

GAGCTAGGCC

GGCAAGATGC

GCACTITTCAG

AACGGGCTGG

CAGAAAAGGG

CTGGCGAGAG

CTGGGAAGGC

AYTMCATTG

TGCAGACCAC

GCC'FrTGGCC

CTGCTTATCT

AGCT1ACCGT TGCTGGCT GGTGTCATTC

GTACCACAGA

TTCAGC11TCC

TCATTCGGAA

CAAGACGGCT

AACTGCATCA

CCAACTCCAT

CCTCAAAGCC

TTATCCATCA

TGCCTGGGCC

A1TATATCTC GTGTTfGGA

AGAATAAGT

TGTGTGTGGT

AATGTCACCT

TCACCTGGAT

CAAACTCAGT

AAGTCCTTGT

TCTACTAA

GATGAACCCT

TGTGTGGTCT

GAGATGACTC

AAGGGATT

CCCCACTCCA

GGCCTGACTT

CATGGCCT

GGTGACTCAT

TTCCATGCCA TTGTGGAAT7 GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGAC1?TAAA CTGCTGAATT C AAATGATAGA CCGTCAATAA !TGTTAAAT GCTTYTTAAA ATGAATGCTT GCGGGTGGAT TGTGTGAGGT AAAAATACAA AAATTAGCCA GAGAATCGCT TGAACCCGGG GACAGAGAGA GACTCCGTCT CACCACTGTT GAATTTTC'rr TTCCCTCTGC AAACTCCCTG TCCAAACCCT GATCCCAGCT TCATTTCCTG TU-ACCAACT TCTCCACCTC CCAACTGAAT TGAAAGCTGG GATGTGGCAG ACACACACAC ACACACCCGC ACAGGGGTCA CTITGGTATCC CTCTAGCCAT GOGACTOAGA GCACAGAGCC CATGCCTGCC GGGAATGGAA GGCCCT-rGGG TTrGACAGCAC CU7GTAAT-rG TATI7AGGTTC AAAGTCCCTC CCAGACCCTG CTGGACCCAA TCCCC1TAA CAGTTCCAGC CCCATCTCTG CCTGCAGG CCAATCAAGC ACTAGGCATG ATCCCAGGTC GAAGCTAATG TGAGCAGCAG CCAGGGCCTA TCATCCCTCC ACCCTGTA GCGTTTGGGA CCCCATGTTC T7IGCAGTTAT TAAGTGACTG CTAGCACCGC TGTGTGGGAG GCCCTGCTGG AGAATGCGTG TTCAGCCCAG GTGTGGCCTC GTTTCTGTCT GTTCGTGAGG TTCACTAGTT AGGGGAGGTG CAACAGTTGA AGGAACCATG GAATCTTGGG AGCAGAGGGA TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TI7GGAGCCGA CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CAUTGTACTC CAGCCTGGGT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG GTGCTrAGGG GTTCCTGCAA ACCT717CCA GGTGTTAATT ACCTCCCACT CAGCTTTTTG T'TfAGTGTG TrTGAATTCC CTGAACTGAC TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC ACTCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT CAAGTCACCA CCAACCCATC TGCGCCTTGT 'FrACCTCCTC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG

CGTTGTCTGA

GCAGAGTGGC

CCACACATGC

CCCTJTCCTAG

TAAGCCCCAC

TGTGAGGCAA

AGCAAGGGTC

AAAAAAGGCC CTFICAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC

GTAAGCCAAG

AAGACCCTGT

CCAGCCCTAT

CITTAACAGT

AGATGGAAGC

TCAGG'TrAC

GGCTAACTGG

ATCGATATTC

GTrCTGCTCA

TATGCTCTCA

AGCAATGTCT

CACGTGACAA

TATTrGGCAA

ACTCACATCC

ACTCCGTGCC

GGCAGACACC

GTGATGTTAA

CCCGAAGGGA

CTCCATCACA

GGGGTCGCAT

TCCAGTCTAA

CATGACACCT

CCTCTAAACT

TCCT"TGCTTC

ACACCAAGCG

CCCTCAGTGT

CAGGACCTTT

GGCTTCTCCA

ACGTCCAGTG

TCCCCAGCCC

CACTCTGAGT

CACCACGGCC

CTGGAGAACT

GCCCAAAGAC

CTGOAAATAC TCAGATGTGT CTGTCTCCCT

GTGCTCCAGT

CCCCACCTGC

ACACATGACC

GCCTCGCCCC

CCTCTGGAAT

CACTCTACCC

CCAACCTGAC

TCTCATCAAT

TGC17GATTT

GTAGACTGTC

AGTCAGGGA(

CTGTGCCAT

CCAAATGTTC

TCTTTrCAGGT

CCCTGGAAAG

AAAACCTCTC

CCAGACCCCT

CTGGAATTCT

TTTrCTCCTCT

TGTCCTCACC

CCAGTCTCTC

CCACTGCAGT

TGAGATATCC

AATCCACTCC

TrCACTGTAC

AGCTCCTAGC

TCAGCAGTCT

TAACCATCT7

CCTCTGAGCT

CCAAAGAACC

AAATCAGCCC

CCATCCATGT

AGTCTCCATC

CCTGACTTCC

TCCTGCACCA

CCTCACAGGC

TTAGGTCAGT

CATTGTATAC

CCATTFCTCC

TTCTTCTCTG

ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC CCTGGYITG117 ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TrAAGGGGAG GAGTAGAAGC AGAGGATAGG GAGATCTGTT CT1'GGGGACA GCATrTGCAA ACTCCAACCT CTCCACCCTG CTGCAGUTGC TGCCTATGAT GAAGATGAGC GCCACAGTGC ACTGGACCTA TAGTCCAA 'I17CCGCACTC AGCAGGCATC TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTGGCT ACTGTCTrGC TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG GCAGGAAATG GGTTI'TCTGT AGCTACAGAA ATGGGGTTGA GGGT1?GGACC TCTTAcc-rrC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA TCTCCCTGGA AGATATCAAT GAGTCAAAGG GATTCCTCAG CTCAACTCTC ATGCCCCGGA AGGTGTCCAA GTCCCTGTTG AGGGAGGAGA AGGGCACATT GAAGAGAGTT AAACATTAAA AAATATCTCC AACACATGGC GGGGAGGAGG ACCTGAGCCA GAAACAAGGC TGAGGGGTCC AGATGGCCAT CTCAGCTGGG TTTCTGATGA TCCGATGGCT TGAGAAATTTr ATAAGCAGCA ACTCTCCAAG CCAGGGGTAT AAGGGACTAC CCAGGGGAAG AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCT-rGGTT GGAAGAITCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTrT7CAAG GTGOCAAGTT GGTTCCCCCC ATGTGGCTGC TGAGTATCC TCACATGGCG GCTCACATCC T-rCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTTr TTGAAATGAA GAATATCAAG TAATTrCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTI=rAG AGCATACTTC TITATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGC11'ACTCC CTCACTCAAC CTCTTGCTAC TrCCCACCTC TCCTGTCCAA CATCTAGTGT CACMIICCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGOTC CACTrGTCCT CCTTrCTTGTC CGGTCAAAAT GCTTCFATC CT-rCAAGiACC CAGCTCTAGA GTCACCTCCA ACCCC1TACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GOCAGGOCAG GGGCCGOGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTJ7GTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC TAGAAGCAAA CGGACT'Tr7C CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTrCCT ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTrGGACT TCTCGCATGC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG

CAGCTGCTCC

GACTCGTAGT

TCTCTCACCC

TTTCAGTGTG

ATTCAGGATG

AGAGCAATAC CCTACTCCAA ACAGCTAGGA GTGGAACTCA ACAAGTCTAG AAAGGTGCCT TAAAGATGAG GTCACCAACA ACTAATGTTT ATTGAGCCTA CTGAGAGGTA GTGGTTTTAA CCCCAGCGTG ACACGGCTTA TCCCCACCCC CCTCGCCATC CACOATOCCA CAGACTGTCC TGGAATCTCC AGGTCTGGAA GAGAGGCTCA AAGTTGACCA TCACGGAAGC YI7CAAGGAGG AGGAAATATC CCAGTGGAGC GCTCTGTAAG ACCCAGGGGA CGGCTTCTCC TTGTCCTGGC TGTGACCGCT GAGGGGTAAC AGGGCCCACT CTTAACGGGA ACCATCCAGC CCCCCTTCCT TCTTCTGCCT GCACAAGAGC GATCCTGGCC TGCGGGCTGC ACGCTCTGCC GCGTGGTGAA TGAGCATCGA CCGCTACCTG CAAGCTCTAC AGC11TGGTGA ATGAAGGAGT ACAGCGATGA AAGTGTI'CAC CAACATGCTC GATGCAGATC ATGCAGGTGC GCCACGGTGC TAGTCCTGGT TCCTGGATAC GCTGCATCGC ACAGATCGCC TCCYFrCATGG cGcT-rcCGAA AGAAGTCTTG TTCAGATGGA GAACTCCATG AGAAGGGAAC ATAGAAGCTC TGGCTGTCCA AGCCCCATGC GCCCTATGGT CTGTGAGTCT ACGGTGGTGT TGGAGTTTAC GTGCAGTGCG TGGGGCATTT CTGCCATG31T ACAGGTGAGG TAAGTAAGGC AGCCAGGATG TGTATCCTCC AATCACTTCA AGGAAGACAG AAACTAGGCA TGATATCATT 'TrTCTC1TT ACTCCC17GG GAGGGCCCCG TCAAGGGTCC AACACI7GAG CTCGAGATGA AGAACATGAG AGAGAGATCA AGCAATTTGC CCAAGACCAC

GTCAGGTGCA

TGGTTGTCCT

AGCCTC'TTC

CCTFTGCCCA

CTGGGTGCTG

AGCTGCACGG

CCTTCTGGGC

TGCCATTATC

GCCCTGGTGA

TCTGGGGGTG

CTGGAGCGCG

TAACCCCTGT

CACTTTCTTT

GAGCAAATGC

1TCGTGCTGG

TGGCAGAGAT

CATCACCATC

TCCATGAACC

AAACCATGTC

TACGCTGCTC

CTCTGCTGAA

TGCCTAAGAA

CACTGATAAT

TGCACATTGT

TCATTGTGGT

TGAACCCAGT

GTGCTTTGCT

GATGGGCTGG

AATAAATTAA

GTUGATAAGG

ATTG'ITAGTG

GCCCCCGTIT

GGCATGCAGA

CTCCTTCTGG

CAGCGCCGAC

CCCCAAGTGG

CCACCCTAGA

CTACCTGOGGG

TCCAACAACT

TGTACAGCAG

CATGGGCCGG

CTGAGCTCAC

GTGTCATCAG

GCTGCCCCTG

AAGTTCAAGG

TCTGCTGGCT

CCAGGACGAG

AACCCACTGG

GCCAGAAAGG

CTCCGTGGAA

GGTAGAGATG

TGAAAGAGGA

AAGGGTGCAA

CTCTGATCCC

TCAAGGACGT

AGGACTATCT

GCATAGAAGG

CCATGGTCTC

CTCACCCACC

AAGGAACGTG

CTGTTGGTGG

AGAACCAAGG

AAACAGCCTG

ACCAG1TrTTT

ATGCTCAATG

AGTGGCTGGG

GAACATCTTT

AACCTGGCCG

TCGACTGGCT

CATCTGTTrC

ATGCGCGGCG

CCATGCTGGT

CTACCCATCC

AGTGTCATCA

AGATCCAGAC

GCCCTTCCAG

CGCATCATCG

TGTACGTGAT

GGGCTGCAGG

CGCCAGATTC

AATTACAGCA

GCCAGTGGGT

AATGTAAATT

TATGACAACC

TAAGTAACTT

GGCTGCAAAG

TAACGGAAAT

CAAGCCAGAC

ACACGGCTTT

AATCCTCCCA

ATACTGGCCA

ATCAGAGGGG

AGCTCCACCT

GTCCTTCCCT

TCACCT-rGCA

CTGGCTCAAC

GTCCTCAGCG

CAGCAGACCT

C1TTGGGGAG

CTGATGCTGG

TGCGCTGGGC

GTrCCGGACC

CTCATCTGGG

CCYUCTGCAC

GGAGAGGAGG

ATCAGCACCT

ATGTAATCAC

CGTGGGCAAG

TCAGAACCCA

ACAAACTGCA

GGGCCACAAC GTCACCGCTr CTGAATGTCG TGGGCTTCCT TGCGGAACAA CGAGATGCAG TGTGCTGCTG CTATTCATCA CTCGGCATCC TCTCCAGCTG CCTACAGCAA CAGCTGCCTC GGAGGTGTAC CAGGGAGTGT GGCACACTGC GGACCTCCAT

GGACTGGGCA

ACAGflGCTT

ATGTCTCCGG

GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA AITTGTGTAA GGAYTGAGGG TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATrGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TG'rrcTTrAr TGCTGCCACA

CCTGAGCCAG

CTCCCGTGTG

GGTGCAATGG

AGGACAATTT

TJ7ATGGCTCC CTI7GCTGTAT.

AGGAACTCAA

GAGCAGGGTG

CACCACCTGT

GCTCCGAGGA

TGAAGTGCCC

TGCTGGGAGG

TGGTCGTGGG

AAAGCACAGA

CTGGCAAGTC

ACCACACAGC

GCGCCAGGCC

CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT4 TTCTCCGTCC CTGCCCCAGC AAGACAACTT CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG CTTGCATTAA TAAAGGTTrAA GCCCTGAGGG CCTCACTGAT GGACAAGGAG GTCTGTGCCA ATGCAGTATT GAGCACTGTA GGCAAGAGGG AGACTCAAGT GGGAACGACT GGGCACTGCC CTGTGGGTGA TATGGACAGC AGAAGGGGGA

GGGGGCAGGG

AGATCTCCAG

TTTCTTTAAT

GTCCCTGATA

ALAGAAGAATC

AAGAAAGAGA

ACCACCAGAA

GCCAGGTTCC

AGAGGAGTGA CTGAGCT-rCC GAGAACTGCC ATCCAGCTTT CTATTCAGCT AGAACTTTGA ACAACCTGGA GACCAGGATr CAATAAGCAC ATATTGAGCA AGGAGCCATC TCCATCTTGA AGCTGUTCGA TGAGACGGTC AGCTCACCAA TACTATrrGCA ACTCCAGCTC TGGCTTrCTGG CCGCAGTACC AGGGAGCGAC TGCTCCAGCC GCCTCACCTC AGCGGGGAGA AGT-CCCTG CCTGCCTC GCCC1TCAAA GATGAGCTGT TCCCGCCGCC GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGOCAGOGOC ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC GAGTT GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CACACCTM CAGAGGGCUT GTGGACTCTG GGCAGCCTGT CCATAGACCT AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA ACCCATAAAC TGATCTGAGA CTCTG1TCC CTGTCTCCAT GATGATGGGA

CATAGGGGAT

CTGTCCCCAA

AGATGAGTCA

GCCAGGGCTA

TCAGGCT1'GA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT GTAAAGTGCT GCAGATAGTr AGTAAGTC1T TGAGCAAAAC AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG CCGCCTGCCC ACCTGGCCAC CCTCTGTTrA CACCTTCCGC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CTTATCTGT7 CTCTTCTGAA GGAAGGGT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT TGAGAAAGCC AGCCTGAGCC TTGACATGGG TCTCAGGGGA GCGCAAACAC CCGTACCCAG TACGTGGCAT GACAAAGAAA TCCCAGGACT GTAAACGCCC ACTGMrACA TCCAAAACTC GAAATAAATG TTACGCGAGG CAAATTTATT GGACGTT[T GCCGTCCCAC GACTCCAACG CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTrCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTFCCCTGT GGTCGTGGGG AGTrrGGGAAA AGT-rCCCTTC CTrCCGGAGG GAGG CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTITC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA AT-TTGCAGG GAGCATGGCT GTGAGGATGjG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCAT-rACTGT TCYUATrGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCGCTG CCCCAGCAAG ACAACTfTAGA TCTCCAGGAG AACTGCCATC CAGCTTGGT GCAATGGCTG AGTGCACAAG TGAGT-fGTTG CCCTGGGTTT C1TAATCTA TTCAGCTAGA ACTITGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCAC1r GCTGTATATG CAGTATrGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCYJ7GAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGYITCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCYT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACT-rAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTrCAAAG TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG CAGTGCCAGG GCAGCACTCA TTCACYI7GAT AAATGAATAT AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGGOCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGAATGAGAA AAATTACAT GGCAAAGAGC MTAAAGCAA AAGCGTGAAA AAAAAGAITC CCTCCTACC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG GGATATGTT'T ACTATAAGGA AAAGACACTG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT ITFCCCACCAC CCTGAGGCCC CAACCGCCAC TCTGATTTGT GATGAGGCAG AGGAAGATAT CCCCACCACC AGCCGGTACC TGGGAAGGGG ACCAAGGGAT TG'I1CCTGTC AATCAATGGT AAAAGGAATG GCAATGGTGT TCACCATCGG TTATTAGCTG GTTGGAGAGC TAGAACCTGG CCTGGAGAGG CTAGAACCAA GAAGGGCTAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG AATCTGGAGA GCTAGAACCT GGAGGGCTAG GGCTAGAACC TGGCAGGYI7A GAACCTAGAA CTGGAAGGGC TAGAACCTGT AGAGCTAGAA TAGAACCTGG AGGGAATGAA CCTGGAGGGC CCATAAATCC TGACCAATCC AACTCTGAAT CCCAACCCAC TCTIT=CC CACCACCCAC TGAAAGAAGA AGTAAAAACC ATTrTAGTATT GAAAAAAAAA AAAAAGAGGC TGTGT1TMGT TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CTGAGTCTGC GGGAGAAGAG CGGCCCTATG AAGACTCAAT GAGCTGTrAT GTTGTAAACA GTGTCTITC TGTAGAGCAT AATAAATGGA CCGTCAATAA TTTGTTAAAT GCT-1TAAA AGTATTAGAA TGAAGTCAAA CACACAGGOC AGTCATTCAG CAATGGCCAT GTGGGGATCC CATGGTGTAG ATGCCCTGAT GGAAGCATr7 CACATCCAAA TGAGGTTr GCAAAAAAAA ATGAATGCTT TAAGCCGGGT TGTGTGAGGT CAGGAGTI'CG AAATTAGCCA GGCATGGTGG CTGTGCCACA CATGGTGAAT CACCAGAGCA CGTGATGOTC ACACCTGGTC TGAGGGGCAA AAAGAACATC TGTCCTGTGA CGAGAAAATC ATGTAAACAT AAAAAAAAA AAATGATAGA

GCAGTGCCTC

AGACCAACCT

CAGGCACCTG

ACATCTGTAA TCCCAGCACT TTrGGAGCCGA GGCCAACATG GCAAAACCTC ACTCTCTACC TGATCCCAGC TACTCAGOAG GCTGAGACAG

GCGGGTGGAT

AAAAATACAA

GAGAATCGCT

TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAATTITC~r TCTATGAGCC CAGGAGGGCC TCTCAGAGAG AAACTCCCTG CC1ITGAAGGT TCAGAAGGAC TGTGCGTGCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTCCA TTTACCAACT CAGCTTTrG TTJTTAGTGTG TTTGAATTCC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACACACCCGC ACTCACACAC TI'GGACATGC ATAGACCACA cTrGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTFGT GAAAGCTCCT AGGTC1TCCT TTCCCTCTGC CG'ITGCATCC TrTGCAAGTG TCCAAACCCT GGTGTTAATT ACCTCCCACT TCATTTCCTG CTGAAGTGAC CGTTGTCTGA TCTCCACCTC GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG ACCCACATAC CCACACATGC ACACACACAC GCTTTCCACA CCCT-rCCTAG ACAGGGGTCA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT TACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA

GGCCCTTGGG

CT[GTAATTG

AAAGTCCCTC

CTGGACCCAA

CAG1TfCCAGC

CCITTGCAGG

ACTAGGCATG

GAAGCTAATG

CCAGGGCCTA

ACCCTGTTTA

CCCCATGTI7C

TAAGTGACTG

TGTGTGGGAG

AGAATGCGTG

GTGTGGCCTC

GTTCGTGAGG

AAAAAAGGCC

GTAAGCCAAG

AAGACCCTGT

CCAGCCCTAT

CTTTAACAGT

AGATGGAAGC

TCAGGTAC

GGCTAACTGG

ATCGATATTC

GTTCTGCTCA

TATOCTCTCA

AGCAATGTCT

CACGTGACAA

TATTGGCAA

ACTCACATCC

ACTCCGTGCC

CYI7TCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TFrGACAGCAC

CCCGAAGGGA

CTCCATCACA

GGGGTCGCAT

TCCAGTCTAA

CATGACACCT

CCTCTAAACT

TCCTTGCTTC

ACACCAAGCG

CCCTCAGTGT

CAGGACCTT

GGCTTCTCCA

ACGTCCAGTG

TCCCCAGCCC

CACTCTGAGT

CACCACGGCC

CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTUC

GTGCTCCAGT

CCCCACCTGC

ACACATGACC

GCCTCGCCCC

CCTCTGGAAT

CACTCTACCC

CCAACCTGAC

TCTCATCAAT

TGCTTGAT

GTAGACTGTC

AGTCAGGGAC

CTGTGCCATC

CCAAATGTT7C

TCTTTCAGGT

CCCTGGAAAG

AAAACCTCTC

CCAGACCCCT

CTGGAATTCT

1TTCTCCTCT

TGTCCTCACC

CCAGTCTCTC

CCACTGCAGT

TGAGATATCC

AATCCACTCC

TTCACTGTAC

AGCTCCTAGC

TCAGCAGTCT

TAACCATCTr

TCTCCCTGGA

GAGTCAAAGG

CTCAACTCTC

AGGTGTCCAA

CCTCTGAGCT CCAGACCCTG CCAAAGAACC TCCCCTTTFAA AAATCAGCCC CCCATCTCTG CCATCCATGT CCAATCAAGC AGTCTCCATC ATCCCAGGTC CCTGACTTCC TGAGCAGCAG TCCTGCACCA TCATCCCTCC CCTCACAGGC GCGTTTGGGA TTAGGTCAGT TTrGCAGTTFAT CATTGTATAC CTAGCACCGC CCATTTCTCC GCCCTGCTGG TrFCTrlCTCTG TTCAGCCCAG AGATATCAAT, GT-fTCTGTCT GATITCCTCAG T-rCACTAGTT ATGCCCCGGA CAACAGTTGA GTCCCTGTTrG GAATCTTGGG AGGGCACATT CCTGGTTGTT AAACATTAAA GTAAATACCC AACACATGGC TGACATTTGG AGGGGAGGTG GGCAGACACC CTGGAGAACT AGGAACCATG GTGATGITAA GCCCAAAGAC AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA ATATGT-rTCT ATCTATCCCA GATGAACTrG GAAGTGAAGG GAAGAGAGTT AGTGGATCAG ACAGCAATGT GCCAGATrGC CTTGGAAACA AAATATCTCC TGGOAGATCA GAACACCCTA AAGAGAGAAT 'FrAAGGGGAG AGAGGATAGG GAGATCTGTT CTTGGGGACA GCAT~rGCAA CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC ACTGGACCTA TAGTTTCCAA 'I17CCGCACTC AGCAGGCATC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TACTI1'GGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG GGTTI'CTGT AGCTACAGAA ATGGGGTTrGA GGGTTGGACC AGAGGACTCT GGAAAGGAGG CTGCAAGYI TCATGGGTCA CTCTGTTCCA AGATGTCTGG GOCCTTrGGTT GGAAGATTCA GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGU- TCACATGGCG GCTCACATCC T-rCCAAGTAA GACCTAGCCT CAGAAATCAC ACACCATCCC GAGGAAGCAG ArrCCTCCTT TTGAAATGAA CACCACAGOG ATCrT'FrAG AGCATACTTC CCTCAC1TCC TTAGCACCCA GTGAAGACCA TCCTGTCCAA CATCTAGTGT CACTTrCCAG GCTG11'CCCC CTGCCTGGTC CACTGTCCT CAGCTCTAGA GTCACCTCCA ACCCCTflACC GCTCCCTCCA GGGCACCCTC CACCCTCTGG

GCAATGCAAA

TGCCACCA7

GAATATCAAG

TTATACCATC

CGCTTACTCC

AACATACCAA

CCTTCTTGTC

CACCAGCCCC

GCCACAGTTG

GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC GAAACAAGOC TGAGGGGTCC ACTCCAACCT AGATGGCCAT CTCAGCTGGG GCCACAGTGC 1TTCTGATGA TCCGATGGCT TCTCAGAGCC TGAGAAATUT ATAAGCAGCA TCTGGTGCTA ACTCTCCAAG CCAGGGGTAT GCAGGAAATG AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAATTCAGA GCCCAGTAGA GACAGCTTAT AAGOCTAGGA AACCAGGAGC CACCAAAAGC GGTTCCCCCC ATGTGGCTGC TI7GAGTATCC AGGCCAAGAA AGATGCTGCA AAGATG1TrAT AGTAAGAAGT CCAGCCCACG TCCAGOAGAA TAAITCGGGG GGCATATGAA AGCCACCACA ACTGTAGTT~C CTTAAGACTC AGGGGCAAAG CTCACTCAAC CTCTTGCTAC TTCCCACCTC CAGCTTCCCC AG1TCTGTGC CTCTGCTCAG CGGTCAAAAT GCTTCTTfATC C'TCAAGACC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG ACAGAGCAGA CGCTCAAAAA ACATrAAAG GGATGCCAGC CAGCTGCTCC TAGAAGCAAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CCC1TTCCT TCTCTCACCC ACAGCACAGG

GTGTCTTCTT

GATAGAAGCA

CGGACT11C

CTCCATGAGC

TGTGYTCTI'G CACTCAGGGC AGAGCTCAGC 'rrGATTrGTG GGTCCCCCAG TCTGGCTCCA CTGGGAAATC CCAGAGGTGA TGATCAGTAA CTGACTATCA GTGGACCTTC CAGAAAGAGC GCACTGGGAA AATGCCCAAT- GAGTCCTGCC TCTGGGTTGT GCITI'GOACT T1rCAGTGTG TCTCGCATCC ACTCTrTCAAC 'FrGAATGT-rG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATITCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATT7GC GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC GTGGTTJTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT CCTCGCCATC TGTATCCTCC AATCACTJTCA GTGCTTTGCT GCATAGAAGG CAG;ACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC AGGTCTGGAA TGATATCA'rr rCTC1TrTT AATAAATTAA CTCACCCACC AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG TTCAAGGAGG TCAAGGGTCC AACACTrGAG AITGTTAGTG CTGTTGGTGG CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTI' AGAACCAAGG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG YTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTF GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC ATGCTCAATG C117AACGGGA CCYI17GCCCA GAGCAAATGC CCCCAAGTGG AGTGOCTGGG CCCCCYITCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCT GCACAAGAGC AGCTGCACGG TOOCAGAGAT CTACCTGGGG AACCTGGCCG TGCGGGCTGC CCT-rCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTfC CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAG1TCAAGG AGATCCAGAC TAGTCCTGGT TGTGCTGCTG CTA'FrCATCA TCTGCTGGCT GCCCTI7CCAG GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG TCCT-rCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGIJCTGCAGG GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA TI7CAGCATGG GCCCAGGAAT GCCAAGGAGA CATGTATGCA CGACC'FrGGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG TCACGCACAG CCAAGGACTC CAAAATCACA ACAGGATTAC TGTTCTTATT CCTGCTCC1T CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA TrCTCCGTCC CTGCCCCAGC AAGACAACTF AGATCTCCAG GAGAACTGCC CTGAGTGCAC AAGTGAGT7G TFFGCCCTGGG 'rrCTTAAT CTATfCAGCT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGY[CC AGCTCACCAA CCTGCCTC CTGCAGAAAA CAGCCTGAGC TCCACCTCGG crTUcT1G CCCCTGTCTC CTrCTGGACC AGTITIGTC CTTCCCTTGT GACCCTGAGG TrTCT-TTCAG CGCCGACATG CTCAATGTCA CCTFGCAAGG GCCCACTCTT CCAAGACCAC ACAGCTAGGA AATTACAGCA ACAAGTCTAG GCCAGTGGGT TAAAGATGAG AATGTAAATT ACTAATGTTT TATGACAACC CTGAGAGGTA TAAGTAACY[ CCCCAGCGTG GGCTGCAAAG TCCCCACCCC TAACGGAAAT CACGATGCCA CAAGCCAGAC TGGAATCTCC ACACGGCThr GAGAGGCTCA AATCCTCCCA TCACGGAAGC ATACTGGCCA AGGAAATATC ATCAGAGGGG GCTCTGTAAG AGCTCCACCT CGGCTTCTCC GTCCT7CCCT TGTGACCGCT TCACCTITGCA AGGGCCCACT CTGGCTCAAC ACCATCCAGC GTCCTCAGCG TCTTCTGCCT CAGCAGACCT GATCCTGGCC CTTITGGGGAG ACGCTCTGCC CTGATGCTGG TGAGCATCGA TGCGCTGGGC CAAGCTCTAC GFTCCGGACC ATGAAGGAGT CTCATCTGGG AAGTGTTCAC CCTrCTGCAC GATGCAGATC GGAGAGGAGG GCCACGGTGC ATCAGCACCT TCCTGGATAC ATGTAATCAC ACAGATCGCC CGTGGGCAAG CGCTTCCGAA TCAGAACCCA TTCAGATGGA ACAAACTGCA GGACTGGGCA GGATTGAGGG ACAGTTGCTT AAATGAGTTG ATGTCTCCGG GCTGTGAGGA TGGGGTGAAC TGCTGCCACA CCTGAGCCAG CTGAGCTTCC CTCCCGTGTG ATCCAGCTI GGTGCAATGG AGAACTGA AGGACAATTT GACCAGGATT UrATGGCTCC ATATTGAGCA CTTGCTGTAT TCCATCTTGA AGGAACTCAA TGAGACGGTC GAGCAGGGTG TACTAUTGCA CACCACCTGT CCCTGGCTGG TTGTCCTTAA GGTAACAGCC TCTTTrCCAC AACGGGACCT TI'GCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGYTC GTGCTGGCCA CCCTAGAGAA CATC'rrTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGO CAGAGATCTA CCTGGGOAAC CTGOCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTrCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGOCCAA GCTCTACAGC T7GGTGATCT GGGOGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCUTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG OCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA T[CATCATCT GCTGGCTGCC CTTrCCAGATC AGCACCTTCC TGGATACGCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GThJGCTTTC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA AATCACAACA GCAUTACTGT TCFI7ATTTGC TGCCACACCT GAGCCAGCCT GAGGCCTGGG GOCAGOGAGA GGAGTGACTG AGCT-cccTc CCGTGTGTTC ACAACTT1AGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTTGAAGG CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC UTCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG AGGTCTAGA TGATCCTATC ACAACCTGAG AGTAGTT17

GCAATGGCTG

ACAATTTCTT

TGGCTCCCCT

TGCTGTATAT

GAACTCAAAG

CAGGGTGCTG

ACAACCACCT

CAGGTATAAA

GGATATGYI1T

ACTCCATTA

AGTAAGGCAG

GTATCCTCCA

AAGACAGAAA

TATCAT=T

CCCTTGGGAG

AGGGTCCAAC

AGAACATGAG

GCATCGCCTC GGCATCCTCT T7CATGGCCT ACAGCAACAG AGTCTTGGGA GGTGTACCAG CTCCATGGGC ACACTGCGGA AGCAGACAGT GAGCAAACGC AGCATGGGCC CAGGAATGCC AACACCGGAG ACTAATTCCT CGCACAGCCA AGGACTCCAA GCTCCTTCCC AGGAGTGGAG TCCGTCCCTG CCCCAGCAAG AGTGCACAAG TGAGTTGTTG GCATTAATAA AGGTTAAGCC CACTGATGGA CAAGGGAGGT GCAGTATTGA GCACTGTAGG ACTCAAGTGG GAACGACTGG TGGGTGATAT GGACAGCAGA GTCCCTGCCT CAGTTCCCTC GTACTTAGAA AAGCAAAGGG ACTATAAGGA AAAGACACTG CAGGTGAGGT CATTGTGGTT CCAGGATGTG AACCCAGTAG ATCATCTTCA GTGCT'ITGCT CTAGGCAGAT GGGCTGGCCA CTCTTTTAAT AAATTAACTC GGCCCCGGTT GATAAGGAAG ACTTGAGATT GTJTAGTGCTG GCCCCGTTTA GATCCAAGGA

CAAGGACGTT

GACTATCTGG

GATAGAAGGT

TGGTCTCCAA

ACCCACCACA

GAATGTGAAT

TTGGTGGATA

TCAGAGGGGG

CTCCACCTCG

ccTITcccTITG

CCTFUGCAAGG

GCTCAACACC

CTCAGCGTCT

CAGACCTGAT

TGGGGAGACG

ATGCTGGTGA

GCTGGGCCAA

CCGGACCATG

ATCTGGGAAG

TCTGCACGAT

AAGTAACTTC

CTGCAAAGTC

ACGGAAATAC

GCCAGACTGG

CGGCTTTGAG

CCTCCCATCA

CTGCAGAATA

CTCTGTAAGA

GCTI'CTCCT-F

TGACCTGAGG

GCCCACTCTT

CCCAGCTCAC ACGGCTTATA CCCACCCTCC CTCGCCATCT GATGCCACAG ACTGTCCAGG AATCTCCAGG TCTGGAATGA

AGGCTCAAAG

CGGAAGCTTC

TCCAGTGGAG

CCCAGGGGAG

GCCCTGGCTG

GGTAACAGCC

AACGGGACCT

GTGACCAACT

AAGGAGGTCA

CCTCAGATGA

TCAGGTGCAC

GTTGTCCTTA

TCTTTTCCAC

TTGCCCAGAG

GGTGCTGTTC

TGCACGGTGG

TCTGGGCCAT

CATTATCTCC

CTGGTGAAAA

GGGGGTGTAC

TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG ATCCAGCCCC CCYI7CCTCTG TCTGCCTGCA CAAGAGCAGC CCTGGCCTGC GGGCTGCCCT CTCTGCCGCG TGGTGAATGC GCATCGACCG CTACCTGGCC GCTCTACAGC TTGGTGATCT

ACCCCTGTCT

TTTCTTTCAG

CAAATGCCCC

GTGCTGGCCA

CAGAGATCTA

CACCATCTCC

ATGAACCTGT

CCATGTCCAT

GCTGCTCCTG

CCTTCTGGAC CAGTTrTTGT CGCCGACATG CTCAATGTCA CAAGTGGAGT GGCTGGGCTG CCCTAGAGAA CATCYFTGTC CCTGGGGAAC CTGGCCGCAG AACAACTTCG ACTGGCTCTT ACAGCAGCAT CTGTTTCCTG GGGCCGGATG CGCGGCGTGC AGCTCACCCA TGCTGGTGTT AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA TGTTrCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA

CCCATCCCTC

GTCATCACCT

TCCAGACGGA

GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTJ7CC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC 17CATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGA'FrCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCYITTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCYI7GGGAAA TGAGTGTJ7GA TGTCTCCGGT AAAACACCGG AGACTAA'ITC CTGCCCTGCC CAA1TTT7CGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATJ7ACT GTTCTITATTU GCTGCCACAC CTGAGCCAGC CTGCTCCYI7C CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTrAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTrGTT GCCCTGGGT7 TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATITAATAA AGGTTAAGCC CTGAGGGGTC CCTI7GATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA ATGTTCTCTC CCTGGAAGAT ATCAATGTr CTGTCTGTTT GTGAGGACTC CGTGCCCACC ACGGCCTCTF TCAGCGCCGA CATGCTCAAT GTCACCT"fGC AAGGGCCCAC TCT1'AACGGG ACCTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG GACGCTCTGC CGCGTGGTGA GTGAGCATCG ACCGCTACCT CCAAGCTCTA CAGCTTGGTG CATGAAGGAG TACAGCGATG GAAGTGTTCA CCAACATGCT CGATGCAGAT CATGCAGGTG GGCCACGGTG CTAGTCCTGG TI7CCTGGATA CGCTGCATCG CCCTJ7CTGGG CCATCACCAT CTCCAACAAC ATGCCATTAT CTCCATGAAC CTGTACAGCA GGCCCTGGTG AAAACCATGT CCATGGGCCG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA AGGGCCACAA CGTCACCGCT TGTGTCATCA CCTGAATGTC GTGGGCTTCC TGCTGCCCCT CTGCGGAACA ACGAGATGCA GAAGTTCAAG 'rrGTGCTGCT GCTATTCATC ATCTGCTGGC CCTCGGCATC CTCTCCAGCT GCCAGGACGA CACAGATCGC CTCCT-rCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GCGC'rrCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG ATTCAGATGG AGAACTCCAT GCACACTG CGGACCTCCA TCTCCGTGGA AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG GACAGYJ7GCT T ATGTJ7CTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGUTC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG

TTCGACTGGC

GCATCTGTTTF

GATGCGCGGC

CCCATGCTGG

GCTACCCATC

GAGTGTCATC

GAGATCCAGA

TGCCCT-FCCA

GCGCATCATC

GTGTACGTGA

GGGGCTGCAG

ACGCCAGATT

AATT-FGTGTA

GTGAGGACTC

TCTTAACGGG

CCCCCCTrCC rGCACAAGAG

CTGCGGGCTG

CGCGTGGTGA

ACCGCTACCT

CAGCTTGGTG

TACAGCGATG

CCAACATGCT

CATGCAGGTG

TCTTTGGGGA

CCTGATGCTG

GTGCGCTGGG

TGTTCCGGAC

CCTCATCTGG

ACC17CTGCA

CGGAGAGGAG

GATCAGCACC

GATGTAATCA

TCGTGGGCAA

GTCAGAACCC

CACAAACTGC

AGGATTGAGG

CGTGCCCACC

ACCTI1TGCCC

TCTGGGTGCT

CAGCTGCACG

CCCTTCTGGG

ATGCCATTAT

GGCCCTGGTG

ATCTGGGGGT

AGGGCCACAA

CCTGAATGTC

CTGCGGAACA

GTTCGTGCTG GCCACCCTAG GTGGCAGAGA TCTACCTGGG CCATCACCAT CTCCAACAAC CTCCATGAAC CTGTACAGCA AAAACCATGT CCATGGGCCG GTACGCTGCT CCTGAGCTCA CGTCACCGCT TGTGTCATCA GTGGGCTTCC TGCTGCCCCT ACGAGATGCA GAAGTTCAAG GCTATTCATC ATCTGCTGGC CTCTCCAGCT GCCAGGACGA ACAGCTGCCT CAACCCACTG AGAACATCTT TGTCCTCAGC GTCYJTCTGCC GAACCTGGCC GCAGCAGACC TGATCCTGGC

TTCGACTGGC

GCATCTGTrT

GATGCGCGGC

CCCATGCTGG

GCTACCCATC

GAGTGTCATC

GAGATCCAGA

TGCCCYJ7CCA

GCGCATCATC

GTGTACGTGA

TCTTTGGGGA GACGCTCTGC CCTGATGCTG GTGAGCATCG GTGCGCTGGG CCAAGCTCTA TGTTCCGGAC CATGAAGGAG CCTCATCTGG GAAGTGYFTCA ACCTrCTGCA CGATGCAGAT CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TITGTGCTGCT GATCAGCACC T"TCCTGGATA CGCTGCATCG CCTCGGCATC GATGTAATCA CACAGATCGC CTCC11TCATG GCCTACAGCA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTr GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCCYFTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT GAGCTCTTCA ATAYITAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGYrTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTI'CC CCAGATCCAC TGGGCCCACT C'rrATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGC7I17CA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC T-rGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC 'JGGGAGCCG TACOTOOCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTrA CACCYI7CCGC GTAAACGCCC ACTGTT-TACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAAMTATT CACATGOGGC TTrCCCAGGCC ACMrGTGGT CAGCCGGGAG GGACGTTIM GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TITCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCT-TCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GT~rTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCUTC CTrCCGGAGG GAGG CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GYIGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATI'TTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA

CGCACAGCCA

GCTCCTTCCC

TCCGTCCCTG

AGTGCACAAG

GCATTAATAA

CACTGATGGA

CAGTATTGAG

CTCAAGTGGG

TGGGTGATAT

GTCCCTGCCT

GTACTTAGAA

ACTATAAGGA

GGTGTGAAGC

CCTGAGGCCC

GATGAGGCAG

AGCCGGTACC

TGTTrcCTGTC AGGACTCCAA AATCACAACA GCATTACTGT TCTI'ATTTGC TGCCACACCT AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTFGGT TGAGTTGTTG CCCTGGGT-rT CITAATCTA TTCAGCTAGA ACTTTGAAGG AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTr1TA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTITGAAGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTFCGACGA GACGGTCGAG GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTAY[GC CAGTTCCCT[ TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATJ7GGG ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTr CCACCTGTCA CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG AGGAAGATAT TTCTAATCGG TCHTGCCCAG AGGATCACAG TGCTGAGACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGYITCC TGTCTCAGCA AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG

GAGCCAGCCT

CCGTGTGTTC

GCAATGGCTG

ACAAT-17CTT

TGGCTCCCCT

GCTGTATATG

AACTCAAAGA

CAGGGTGCTG

ACAACCACCT

CAGGTATAAA

GGATATGTTT

AGCCGGTGGC

TTCCCACCAC

TCTGATTTGT

CCCCACCACC

ACCAAGGGAT

AAAAGGAATG

GCAATGGTGT TCACCATCGG CAOTGCCAGG GTITGGAGAGC TAGAACCTGG AGAGCTAGAA CTAGAACCAA GAAGGGCTAG AACCTGGAGG GAGGACTAGA ACCTGGAGGG CTGGAATCTG ACCTGGAGGG CTAGAACCTG GAGGGCTAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG TGGCAGGTTA GAACCTAGAA GGGCTAGAAC TAGAACCTGT AGAGCTAGAA CATGGAGAGC AGGGAATGAA CCTGGAGGGC TAGAACCTGG TGACCAATCC AACTCTGAAT TTTAAAGCAA GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG

CCTGGAGAAC

GGCTAGAACC

AAGGGCTAGA

ACCTAGAAGG

GCTAGAACCT

CTGGAGAGCC

TAGAACCCGG

AGAATGAGAA

AAGCGTGAAA

TAGAACCTGG AGGGCTAGAA CCTGGAGAGG TAGAGAAGCT AAAACCTGAG CTAGAAGCTG ACCTGGAGGG CTGGAATCTG GAGAGCTAGA GCTAGAACCT GGAGGGCTGG AATCTGGAGA AGAAGGGCTA GAACCTGGAG GGCTAGAACC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AAATrACAT GGCAAAGAGC CCATAAATCC AAAAAGATTC CCTCCTFACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC AT'FrAGTATr AGTATTAGAA AAAAAGAGGC TGTGTTGT CACACAGGGC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GGGAGAAGAG CGGCCCTATG CATGGTGTAG GAGCTGTTAT GTTGTAAACA GGAAGCATTT TGTAGAGCAT AATAAATGGA TGAGGTTTr TIrTGTTAAAT GC'FFITrAAA ATGAATGCTT TJTGGAGCCGA GCGGGTGGAT TGTGTGAGGT ACTCTCTACC AAAAATACAA AAATTAGCCA GCTGAGACAG GAGAATCGCT TGAACCCGGG CAGCCTGGGT GACAGAGAGA GACTCCGTCT CATGATCTCT CACCACTG'rr GAAT'FrrCTT AGGTCUTCCT TTCCCTCTGC AAACTCCCTG TVITGCAAGTG TCCAAACCCT GATCCCAGCT ACCTCCCACT TCATTTCCTG TTTACCAACT CGTTGTCTGA TCTCCACCTC CCAACTGAAT TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC GCAAAAAAAA AAAAAAAAA AAATGATAGA CCGTCAATAA TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCT-rCAAACA TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC GTGCTTAGGG GTTCCTGCAA ACCTTCCA GGTGTTAATT CAGCTrTTTTG TTTTAGTGTG YTTGAATTCC CTGAACTGAC TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGT-r GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC.ACACACACAC ACACACCCGC ACTCACACAC T -rGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTITGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGOGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTfGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATI7AGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCC1TTIAA CAGTTCCAGC CTYI7AACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCUTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTUTGGGA CCCCATGflC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC U-AGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT T-rcTrCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATG11TC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCT-rTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACAUTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC TGAGGGGTCC ACTCCAACCT CTCAGCTGGG GCCACAGTGC TCCGATGGCT TCTCAGAGCC, ATAAGCAGCA TCTGGTGCTA CCAGGGGTAT GCAGGAAATG CCAGGGGAAG TCYI7ACCTTC GCCCAGTAGA GACAGCTTAT AGAGGATAGG GAGATGTGTT CT-TGGGGACA GCA'ITTGCAA GAAACAAGGC CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTrTCTGATGA AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA

AACCAGGAGC

ATGTGGCTGC

AGATGCTGCA

CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GG7F7CCCCCC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GGCATATGAA AGCCACCACA CACCACAGGG ATCITY[TAG AGCATACYI7C C117AAGACTC

CTCTTGCTAC

AGTTCTGTGC

GCTTCTTATC

CTGTGTCCCA

GGCAGGGCAG

CGCTCAAAAA

CAGCTGCTCC

GACTCGTAGT

AGGGGCAAAG CCTGACTTCC TTAGCACCCA TTCCCACCTC TCCTGTCCAA CATCTAGTGT CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CTTCAAGACC CAGCTCTAGA GTCACCTCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC GGGCCGGGTG GTGTCTT1CTT TGTGTTC'ITG ACATTTAAAG GATAGAAGCA TTGATTTGTG TAGAAGCAAA CGGACT'TrTC CTGGGAAATC TCAGCTCTTC CTCCATGAGC CTGACTATCA

GTGAAGACCA

CACTITTCCAG

CACTTGTCCT

ACCCCYI'ACC

CACCCTCTGG

CACTCAGGGC

GGTCCCCCAG

CCAGAGGTGA

GTGGACCTYJC

GAATATCAAG

TTATACCATC

CGCTITACTCC

AACATACCAA

CCTTCTTGTC

CACCAGCCCC

GCCACAGTTG

AGAGCTCAGC

TCTGGCTCCA

TGATCAGTAA

CAGAAAGAGC

TCTGGGTTGT

TAATJTCGGGG

ACTGTAGTTC

CTCACTCAAC

CAGCYI7CCCC

CGGTCAAAAT

CTCTCCAAGT

TCAGGAGTCA

ACAGAGCAGA

GGATGCCAGC

TCTCTCCCGT

CCCTITTTCCT

GCT-rTGGACT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC T-rTCAGTGTG TCTCGCATCC ACTCTT1CAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AATTACAGCA ACAAGTCTAG GCCAGTGGGT TAAAGATGAG AATGTAAATT ACTAATGTTT TATGACAACC CTGAGAGGTA TAAGTAACTT CCCCAGCGTG GGCTGCAAAG TCCCCACCCC TAACGGAAAT CACGATGCCA CAAGCCAGAC TGGAATCTCC ACACGGC'TF GAGAGGCTCA AAAGGTGCCT GCCCTATGGT GTCACCAACA ACGGTGGTGT ATTGAGCCTA GTGCAGTGCG GTGGTTTTAA CTGCCATGTT ACACGGCUFA TAAGTAAGGC CCTCGCCATC TGTATCCTCC CAGACTGTCC AGGAAGACAG ATAGAAGCTC AGAGAGATCA AGCAATTTGC AGCCCCATGC CTCTGCTGAA GGTAGAGATG CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA TGGAGTTTAC CACTGATAAT AAGGGTGCAA TGGGGCATT7 TGCACATTGT CTCTGATCCC ACAGGTGAGG TCATTGTGGT TCAAGGACGT AGCCAGGATG TGAACCCAGT AGGACTATCT AATCACTTCA GTGCTTTGCT GCATAGAAGG AAACTAGGCA GATGGGCTGG CCATGGTCTC AGGTCTGGAA TGATATCATT TITTCTCTFTT AATAAATTAA CTCACCCACC AAGTTGACCA ACTCCC'rrGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG 53 AATCCTCCCA TCACGGAAGC T[CAAGGAGG TCAAGGGTCC ATACTOOCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTFGTCCT GTCCT-rcCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC TCACCTTGCA AGGGCCCACT CTfAACGGGA CCTTTGCCCA CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG GTCCTCAGCG TC'rrCTGCCT GCACAAGAGC AGCTGCACGG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAA( CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG AACACTTGAG ATTGT-rAGTG CTGTTGGTGG AGAACATGAG GCCCCCGT-rT AGAACCAAGG CTGGAGCGCG GGCATGCAGA AAACAGCCTG

TAACCCCTGT

CACTITCT[

GAGCAAATGC

TTCGTGCTGG

TGGCAGAGAT

CATCACCATC

TCCATGAACC

AAACCATGTC

TACGCTGCTC

GTCACCGCTT

TGGGCITCCT

CGAGATGCAG

CTATTCATCA

TCTCCAGCTG

CAGCTGCCTC

CTCCFrCTGG

CAGCGCCGAC

CCCCAAGTGG

CCACCCTAGA

CTACCTGGGG

TCCAACAACT

TGTACAGCAG

CATGGGCCGG

CTGAGCTCAC

GTGTCATCAG

GCTGCCCCTG

AAGTTCAAGG

TCTGCTGGCT

CCAGGACGAG

AACCCACTGG

ACCAGTTTT

ATGCTCAATG

AGTGGCTGGG

GAACATC1TTT

AACCTGGCCG

TCGACTGGCT

CATCTGTTTC

ATGCGCGGCG

CCATGCTGGT

CTACCCATCC

AGTGTCATCA

AGATCCAGAC

GCCCTTCCAG

CGCATCATCG

TGTACGTGAT

ccTJ7CTGCAC

GGAGAGGAGG

ATCAGCACCT

ATGTAATCAC

(3ATU-CAGjATC ATGCAGGTGC TGCGGAACAA GCCACGGTGC TAGTCCTGGT TGTGCTGCTG TCCTGGATAC GCTGCATCGC CTCGGCATCC ACAGATCGCC TCCTTCATGG CCTACAGCAA CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG TCAGAACCCA T-FCAGATGGA GAACTCCATG ACAAACTGCA GGACTGGGCA GGGAGCAGAC GGATTGAGGG ACAGTTGCTT TrCAGCATGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GCTGTGAGGA TGGGGTGAAC TCACGCACAG TGCTGCCACA CCTGAGCCAG CCTGCTCCT-r CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC ATCCAGCTUT GGTGCAATGG CTGAGTGCAC AGAACThrGA AGGACAATTT CTI7GCATUAA GACCAGGATT T-rATGGCTCC CCTCACTGAT ATATITGAGCA CTTGCTGTAT ATGCAGTAYUF TCCATCTTGA AGGAACTCAA AGACTCAAGT TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TACTATTGCA CACCACCTGT CCTGCCTC C CCCTGGCTGG TITGTCCTTAA CCCCTGTCTC GGTAACAGCC TCTTTTCCAC 'ITCTTTFCAG AACGGGACCT TTGCCCAGAG CAAATGCCCC CCTTCCTCTG GGTGCTGTTFC GTGCTGGCCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA GGGCTGCCCT TCTGGGCCAT CACCATCTCC TGGTGAATGC CA'FrATCTCC ATGAACCTGT CTACCTGGCC CTGGTGAAAA CCATGTCCAT TrFGGTGATCT GGGGGTGTAC GCTGCTCCTG GCGATGAGGG CCACAACGTC ACCGCT7GTG CATGCTCCTG AATGTCGTGG GCTI7CCTGCT CAGGTGCTGC GGAACAACGA GATGCAGAAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA TrCATGGCCT ACAGCAACAG CTGCCTCAAC AGTCTTGGGA GGTGTACCAG GGAGTGTGCC CTCCATGGGC ACACTGCGGA CCTCCATCTC GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTfGGG GAGACTAATT CCTGCCCTGC CCAAT-FTTGC AGGGAGCATG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT 'CCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGIGA CTGCCCCAGC AAGACAACYJ7 AGATCTCCAG GAGAACTGCC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTA'FrCAGCT TAAAGGTTFAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA G3GACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC 3AGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC

GGGAACGACT

TATGGACAGC

TGCAGAAAA

CTTCTGGACC

CGCCGACATG

CAAGTGGAGT

CCCTAGAGAA

CCTGGGGAAC

AACAACTTCG

ACAGCAGCAT

GGGCCGGATG

AGCTCACCCA

TCATCAGCTA

GCCCCTGAGT

TTCAAGGAGA

GCTGGCTGCC

GGACGAGCGC

GGGCACTGCC

AGAAGGGGGA

CAGCCTGAGC

AG'TITTGTC

CTCAATGTCA

GGCTGGGCTG

CATCTI'TGTC

CTGGCCGCAG

ACTGGCTCTT

CTGTTTCCTG

CGCGGCGTGC

TGCTGGTGTT

CCCATCCCTC

GTCATCACCT

TCCAGACGGA

C'I1TCCAGATC

ATCATCGATG

ACCACCAGAA

GCCAGGTTCC

TCCACCTCGG

CY-rCCCYTGT CCTrGCAAGG

GCTCAACACC

CTCAGCGTCT

CAGACCTGAT

TGGGGAGACG

ATGCTGGTGA

GCTGGGCCAA

CCGGACCATG

ATCTGGGAAG

TCTGCACGAT

GAGGAGGGCC

AGCACCTTCC

TAATCACACA

AGCTGTTCGA

AGCTCACCAA

CTTCTCCTTG

GACCCTGAGG

GCCCACTCTT

ATCCAGCCCC

TCTGCCTGCA

CCTGGCCTGC

CTCTGCCGCG

GCATCGACCG

GCTCTACAGC

AAGGAGTACA

TGTUCACCAA

GCAGATCATG

ACGGTGCTAG

TGGATACGCT

GATCGCCTCC

TTCCGAAAGA

AGATGGAGAA

CTGGGCAGGG

CCACTGGTGT ACGTGATCGT GGGCAAGCGC AGAAAGGGGG CTGCAGGTCA GAACCCATTC CGTGGAACGC CAGATTCACA AACTGCAGGA AGCAGACAGT GAGCAAACGC CAGCAGGGCT AGCATGGGCC CAGGAATGCC AAGGAGACAT AACACCGGAG ACTAATTCCT GNCCTGCCCA CGCACAGCCA AGGACTCCAA AATCACAACA GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG TCCGTCCCTG CCCCAGCAAG ACAACTTAGA AGTGCACAAG TGAGT-rGTTG CCCTGGGT GCTGTGAATTr TGTGTAAGGA TTGAGGGACA GTTGC'TrrFC CTATGCACGA CC1TGGGAAA TGAGTTGATG TCTCCGGTAA A1TrGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GGCAGGGAGA GGAGTGACTG AGC'rrCCCTC CCGTGTGTTC TCTCCAGGAG AACTGCCATC CAGCTT-rGGT GCAATGGCTG C1TAATCTA ITCAGCTAGA ACTGAAGG ACAA'rTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTfGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT GAGTTCCCTC TI7CTGTAACA TGAAGTCGTT GTGAGGGUTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCA11TACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA TGATCCTATC ACAACCTGAG AGTAGTTTTr ACTCCATTTA CAGGTGAGGT CATTGTGGYF CAAGGACGTr AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCT-FTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTTTT CTCThrrTAAT AAATTAACTC ACCCACCACA CGGCTTTFGAG AGGCTCAAAG GTGACCAACT CCCYU7GGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCT-rC AAGGAGGTCA AGGGTCCAAC ACTTGAGATf GT7AGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTYUA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC TC1TTTTCCAC TTrC1TTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC ccT-rcCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCT[ TGGGGAGACG CTCTGCCGCG TGGTGAATGC CAUTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC c~rcCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC 11TCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTrC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCYI7GGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GYJ7CT[ATTT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTTr GCCCTGGGTT TCTITAATCT ATCAGCTAGA ACTTTGAAGG ACAATCT-r GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCITGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA ATGUTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACcT-rTGcCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCC1TrCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTrCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTrGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTFCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACC7I17CTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATF[CATC ATCTGCTGGC TGCCCTTrCCA GATCAGCACC 'rrCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGiTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ACGCCAGATT CACAAACTGC AATITGTGTA AGGATTGAGG GTGAGGACTC CGTGCCCACC TCTTAACGGG ACCTTTGCCC CCCCCCTJ7CC TCTGGGTGCT TGCACAAGAG CAGCTGCACG CTGCGGGCTG CCCTTCTGGG CGCGTGGTGA ATGCCAT-rAT ACCGCTACCT GGCCCTGGTG CAGCTTGGTG ATCTGGGGGT TACAGCGATG AGGGCCACAA CCAACATGCT CCTGAATGTC CATGCAGGTG CTGCGGAACA CTAGTCCTGG TYfGTGCTGCT CGCTGCATCG CCTCGGCATC CTCCTTrCATG GCCTACAGCA AAGAAGTCTT GGGAGGTGTA AGAACTCCAT GGGCACACTG AGGGAGCAGA CAGTGAGCAA GCCCTCAAA GATGAGCTGT CGGTGGGGAC ATCAGGCTGC

ATTCAGATGG

AGGACTGGGC

GACAGTTGCT

AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG T ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTrC ACGGCCTCTT TrCACCCGA AGAGCAAATG CCCCCA-AGTG GTTFCGTGCTG GCCACCCTAG GTGGCAGAGA TCTACCTGGG CCATCACCAT CTCCAACAAC CTCCATGAAC CTGTACAGCA AAAACCATGT CCATGGGCCG GTACGCTGCT CCTGAGCTCA CGTCACCGCT TGTGTCATCA GTGGGCTTCC TGCTGCCCCT ACGAGATGCA GAAGTTCAAG GCTATTCATC ATCTGCTGGC CTCTCCAGCT GCCAGGACGA ACAGCTGCCT CAACCCACTG CCAGGGAGTG TGCCAGAAAG CGGACCTCCA TCTCCGTGGA ACGCCAGCAG GGCTGCTGTG TCCCGCCGCC ACTCCAGCTC CATUCTCAAT GTCACCTTGC AAGGGCCCAC GAGTGGCTGG GCTGGCTCAA CACCATCCAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC GAACCTGGCC GCAGCAGACC TGATCCTGGC TTCGACTGGC TCTTTGGGGA GACGCTCTGC GCATCTGT11T CCTGATGCTG GTGAGCATCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CCCATGCTGG TGTTCCGGAC CATGAAGGAG GCTACCCATC CCTCATCTGG GAAGTGTTCA GAGTGTCATC ACCTTCTGCA CGATGCAGAT GAGATCCAGA CGGAGAGGAG GGCCACGGTG TGCCCTTCCA GATCAGCACC TTCCTGGATA GCGCATCATC GATGTAATCA CACAGATCGC GTGTACGTGA TCGTGGGCAA GCGCTTCCGA GGGGCTGCAG GTCAGAACCC ATTCAGATGG ACGCCAGAYI7 CACAAACTGC AGGACTGGGC AATTTGTGTA AGGATTGAGG GACAGTTGCT T TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGC11T GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTTr GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT

CCCAGCACAG

GCCCTTCAAA

CGGTGGTGAC

CTCCGGAGAA

CCAGCACAGA

GAGCTCTTCA

ATATrTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC CACACCTTr CAGAGGGCTT AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTrCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGYITTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCT-rCA AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TI'GACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTrCTGCC ACTGTCGCCC TrGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTrTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TrACGCGAGG CAAATTTATT CACATGGGGC 'FTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TrCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTr CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTrCAAAG ATGAGCTGTr CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTOCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC cTTrcCGGAGG GAGG GAATJTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATrTCCTCA AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TflTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTA'rrGC CCACAGCAGA CTAAAATTAC TTCAGcT-C AAATACATTA ACACTGTGAT ATCTTrGTACT A1TTTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCA'TrA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTrGGAGA CCUrATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTr AAGCTGCTGG 56 CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC TGGAGTCGTG TTCAGGGAAT TGGGATTFCCT TTGGTAAGTG CCATTGAAAT TGTCTCCATG CCTITATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTr GAATATAGGG TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG TfCGGGTTCT ATTTCTGTAT GCCCTrGGTG TGCACTGCGA TCTTCTACAC

TGAACAGAAG

AACAGTTTTC

AAAACTGTGT

TCGGTATTAA

TAAAAATTGT

ATGAACGGAA

AGGACAGCAT

CACAAGGCAA

GAATGGCAGC

TGCTTGGTTG

ATAACGAGAT

CTTGGCAACC

TTFCCAGTCAT

CAAGCATCCA

GAACTGACCA

CTGTGAGTCC

TTGAGAATTG CCCTCAGTGA ACATCTTAAG TAATrTTGC TCTTTGCTGG TTCCCTCT-fC GGACAAGAAC CGATGTGAAT TACTTAGTTT

ATGTAAAGGA

CCTCATGACT

CAGCGTCGAG

ATTTAAGCCG

CYI7ACTGCTC

TATTTTGTGA

GTCTGATGAC

CACAGACCGG

ATCCTCTCGG

ATTCACTCCC

TTTTGCAGAA

AGTTGCCTCC

TGGATCCTGT

GTGAACAGCA

CTGGTGGCTC

TGTGAGATGT

AAGTGGCAAA

TATATTGAAG

ATGGATTACA

GCAAGAAATT

CTCGGTCCCC

AGCAGCCATA

AGAAAAAAAT

ACACCCAAGA

ATGAATTCAT

GCCTCTGCTG

GTGGAAGAAC

CCCTTAGAAG

GGGAATCTCT

GTATAAACCC

CTGCTGTTAC

CACGATCAAA

CACTCCTCGG

TCTCTGATCC

CATAGCTCTG

CAGTCCAAAA

ACAACCACAA

TACTCCCATA

TTC'FrCCTTA AGAAATGCTTr TCCAAAACCG CAAGGGTAGA CTGGTI1'ATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAAT-rGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCT-rTTA

CAAGAYTITC

TTAU-TGAAA

TCCYFTTGGC

ATCATGTGGA

TAATTTGGTC

T1TCAAATACA

TCAGGATCAT

AGACCTTATC

GATCACAATG

CCGTCCTCAA

AATTGGGATT

CCTGAAGCGA

ATGCCACATC

TGGCAGTTCT

TACTTThTIT

TGTCATTTGG

TGGCACTGGT

TGATI1TCACC

CTACCCAGCA

TTAACACTGT

TTACCAGAAC

TATGTGGTCA

ACTTTGGCGT

CCTCTGCGCT

CCTTTGGTAA

TTGGCYTCGT

AAAATTCATG

GGTGAATGTT

AAGTGATTTT

TGCCAGTATC

TGGATGTGTA

ACT11CGTG

ATGGCTCAAT

GATATCI17GT

AAATGTATGA

TTGATCTCCC

A11'TCTTTGC

CTTAGTGTTG

CTGCCATTGA

CATGGTACCC

GAGTTCTACC

CAATGGGAAC

TTTGTCCTTC

CCGAATTC

ATCAGTGATA

GCACAGAGCT

GCACAACTAT

ACTATT'TrCA

TGGTCACCAT

AGCCAAACAC

GCCACCATGG

ATCCTGAGAG

CAGCTTCCTG

TGCCCACAGC

TCGTGGGAAT

GAAACTTTAG

AATATGGGCT

AAACCCT-rTG

ATACAGGACA

GT[ACCACTC

AGACTAAAAT

GGTGGGGAAT

ATAGCCAGTC

TGGCTGGGCG

GAAGTCCTCG

TCCTGGAGTC

TGTCCTTTAT

GCATAAAACC

CTCTTCGGGT

AGATTAACGA

CAAGTCACTT

CCTCAGGGCA

AATCTAAGCA

ATCAACCCAC

TACTTCAGCT

GCAACTCTGC

TTGCCCTITGG

CTGGCCT1TTT

GTGGGGATCA

GTGTTCAGGG

CCTGGCCATT

TGTATGCTCA

TCTATTTCTG

GGAATGGCCC CAACGCGCTG TATCAATGTA T~FAAGCTGC AAGCTGTTCC CC1TFTTGCA ACAGGTACAG AGCAGTTGCC AATTGCCTCC ATCTGGATCC =TGAATATA GGGGTGGACA AAGATGTAAA GGACTGGTGC TATGCCCTfrG GTGTGCACTG CGATCTTCTA CACCCTCATG ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAAACAGTrf TTCTGCTTGG TTGTAATTTT TGCTCTTTGC TGGTTCCCTC TrCATTTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATTACTTAG TTTCTTACTG CTCATGGATT ACATCGGTAT TAAC'I17GGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATrTTG TGAGCAAGAA AYITAAAAAT TGTITTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTrAG AAGCACTCCT GAATfCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA

TATTTCCTCA

ATGTGTAATC

TTTCGTGGCA

GCTCAATGCA

ATCTTGTACT

TGTATGAGGA

ATCTCCCTAT

TCT11'GCAAG

AGTGTTGACA

CCATTGAAAT

GGTACCCT-T

T-rCTACCAAG

TCTTCTACAC

AATTTGCCTC AAGATGGAAA CCCT-rTGCCT CAGGGCATCC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC CAGAGCTCAG CTTCCTGGTT ACGACTCATC AACCCACTAA CAACTATTGC CCACAGCAGA CTAAAArrAC TFTCAGCTTC ATJ7TTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA ATGGCCCCAA COCOCTGATA GCCAGTCTTG CCCYITGGAGA CAATGTAT1T AAGCTOCTGG CTGGGCGCTG GCCTIIGAT CTGTTCCCCT 11TGCAGAA GTCCTCGGTG GGGATCACCG GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TCAGGGAAT TGTCTCCATC TGGATCCTGT CCY[rTATCCT GGCCATTCCT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG ATGTAAAGGA CTGGTGGCTC 1TTCGGGTTCT ATTTCTGTAT CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC

TTTTGGCTGG

ATGTGGATGA

TTTGGTCCTA

AAATACATTA

GGATCATTTA

CCTTATCTAT

CACAATGACT

TCCTCAACCT

TGGGATTCCT

GAAGCGATTG

CCACATCAAA

GCCCT-rGGTG

TTGAGAATTG

CACTGGTTGG

TTTCACCACT

CCCAGCAATG

ACACTGTGAT

CCAGAACAAA

GTGGTCATTG

TTGGCGTATT

CTGCGCTCTT

TTGGTAACTG

GCTTCGTCAT

ATTCATGGAG

TGCACTGCGA

CCCTCAGTGA

ACATCT-rAAG CAGCGTCGAG AAGTGGCAAA AACAGTT-7TC TGCTTGGTTG TAATTTTTGC TCTTTGCTGG TTCCCTCTTC ATUAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTr CTTACTGCTC ATGGATTACA TCGGTAT1TAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TAYTITGTGA GCAAGAAAUT TAAAAATTGT 'FrCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA 57 ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TTCTTCCTTA AT-FCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA

CACTCCTCGG

TCTCTGATCC

CTGGTTTATC

CACCCACAAC

ACTAAAAAAT

TGCATGAAAA

TGGTCACCAT

AGCCAAACAC

AACAAGAAAA

ATGTATAAAC

ATTAGTJTATT

TAAAATGTAG

TTAGGATAAC

ATCCCACYT

TGCTAGACCT

GAGTAAGTGG

AAACCAGGCA

GCCTATATTT

GATCTTCATG

TGATAGAATG

ATCTACGAAT

GGTGGGAGCT

TAGAGCTTTC

GAAACTTTAG

AATATGGGCI

GCGTTGGTAG

AGTACATCAT

TAATAGTTGG

ATAGTGATAG

ACCTGGCATA

TCTAAGTTGT

ATGCCTATGC

GTAAATATTA

CAGCTGATGG

GAAGCCTTA(

TGGAATGACT

GTTFCCTCAAG

CGTACITCTT TAATTGATCT AATUTACATA TTCTGCGTGT TGTATTCAGC GGGGGAGAkAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACYTTT AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC AGATTAACGA CAAGATTUTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC VCAAGTCACTT TTAUTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT GCTCCTGAAT ATGACTAAGA GTTTGACTTA GGGGTTAGAT TTTATGTGTT TGAACCCCAA CACCCCAAAA CAAGTTACTT AACCTCACTA AGGTTCAGTT TTCCTGTTTA TATGTACTTT ATAGGATTAT TGTGAAAAAT AAATGAAATA TCAGATTTAT TGTTTGGTAT TCAGAATTAG TTGCTGCTGT 1TTATTCTGC TCTCCCT-FGC AAACTAAATA GTTGTACACA GATTGACAGA TTAAGAAAGG CTTGTGATTG CTCTGTCTCA CCAGA17CCA GGTGTATATG TGGAGGTGGG ATAGGGAGTG AATTGCCCAG 17GGGCACCA TCCTGAATAT TATCTCTAAA GAAAGAAGCA GTTAACCAGA TATGATACAG AAAACATTTC CTTCTGCTT-T TTGGTTT[AA ATCTCTGCAG CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG GGTTTCATTC AATAGACTTA ATTCAGCAGT CTGTGGGGAA GAGCAAGGTA TGCFI'CAGAT GTGAAGTGGG fTTAAATATA CTGTCCCTGT CTTCTTCAGA GTTTTGGTAA AGATAAAATA GGACACTCAT TTAAAAGCAA TCU-TGCAAA TAATAGAGTT TTCAYT-CCA GTATTATCAT TAATATCAGA TCCTGGAAGA GCAAAAAAAC AGAAGAATTA GTAAAGGAAT CCTGGAGAAA GCCCCTGCTG

AGATCATGTT

GCCTAGATCC

AGAAAGAGGA

AAATTTGTGG

ATCCCAAAAG

AGTTTGACTT

ACAAGUrACT

TATAGGATTA

TTCAGTAATT

TAGTTGTACA

ATTCCAGGTG

GCACCATCCT

ATACAGAAAA

GGGAAATTAT AATATTAAAA CCATAAGTAA TGGTTTAACT GTCTCTGAAA ATGTTTCCAA AFITATGCAC TAACTGATCA AAITTGGCAG T-TGCTAGCCA

AGGGGTTAGA

TAACCTCACT

TTGTGAAAAA

AGTTGCTGCT

CAGATTGACA

TATATGTGGA

GAATATTATC

CATTTCCTTC

TTI'TATGTGT

AAGATTCAGT

TAAATGAAAT

GTTTTATTCT

GATTAAGAAA

GGTGGGATAG

TCTAAAGAAA

TGCTTTTTGG

GTAAACAAAA

TCTGCCTI'CC

TTTCGCTGGT

GCAGGAAATT

TGCTCCTGAA

TTGAACCCCA

T[rTCCTGTT

ATCAGATA

GCTCTCCCTT

GGCTTGTGAT

GGAGTGGAGT

GAAGCAAAAC

TTTFTAAGCCT

GCTAGGAAGT

TGTGTTCTGA

CAGACAGCGG

AAACAAGAAA

TATGTATAAA

AATTAGTTAT

ATAAAATGTA

TFTTAGGATAA

GCATCCCACT

TGTGCTAGAC

AAGTGGGTAA

CAGGCACAGC

ATATTTGAAG

TGACAAGCCA

AGGTTGAGCC

TGTATFI'AAA

AAAATAAAAT

GCCAGATTAG

ATCATCAGTG

AGCGTTGGTA

CAGTACATCA

TTAATAGTTG

GATAGTGATA

CACCTGGCAT

TrTCTAAGTT

CTATGCCTCT

ATATTAAATT

TGATGGGTTA

CCTTAGATCT

ACTCTACTGT

CTATAGACAT

YTGACCTAGA

GGAGAAAGGG

AAATTATATG

GGCACAGTAG

AATCAGATGA

GCTCTGGTGA

TATGACTAAG

GCACCCCAAA

GTATGTACTT

ATGTT-rGGTA

GTAAACTAAA

CTCTCACCAG

GCCCAGTTGG

ACCAGATATG

CTCCAGCACA

GTGTAGCCTT GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTGTTCTTC GGTAAGTAGA GATTCAATTA CCCCTCCCAG GGAGGCCCAA ATGAATTTGG GGAGCAGCTG GGGTAGGAAC CTTTACTGTG GGTGGTGACT T-rTTCTAGGA CATGTGCAAA CTATTGGGCA TFITCCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG AGGCAAGTGG GCTGAGCAAC ACCTAAGGAG GAAGCCAGAC TGAAAGCT11G GTTCCTTrGCA TTTGCTCTGG CATCTTCCAG AGTGCAAAFJT TCCTACCAAG GTAATGAGGG TAGAGGAGAG AAAGAAGCTC TTTCTTCCCC TGATTCTCAT TCCTGAAAAG ACGGTTGGTC CUrAAAATTC

CATGGATGTA

ATGTATCCTC

TGGTGTATCA

ATGAGCATGA

TGATFrCATTG

CATGTCTCAT

CA1TTATAA

ACGTAAGTTC

ACTTCTiTTG

TJTAGTGCCTC

CATAAATATT

CTCATTCATT

AAGAGATTGC

ACATAGTGAA

GATC'ITATCC

TCTGGACT1T

ACATGTCTGG

ATCTGTIVCCT

CAT1VCTCTCA

TCTCTCTCCT

TTGAGGATGC

CT7GGATCTA TCTCTGTrTCA

CCACACCCAG

TGCAGCTCCA

GCATTGC=F

TGGCCAGACT

AGTCATTCTC

AGACACT-17G

TGAAACTCAG

AGTCCAGTTC

AATGCACT

ATTCTAGTCC TCTGGAGATA AAGAAGACTG CTGGACACTA

GATGGCGTGT

CCTCTCACTA

ACTTTCCCTC

TCCTCTGTrT

GCATGATCTC

TGAT1TCTG

TCTTCTGACT

ACATCCCCYUr

CATATGTT

TATTTCATCC

TAACAATGGT

GAATTGAAAT

TCTCCTGCAT

TAGCAGGTGA

TTT-rCTTCGT

TCCACCTTGC

TAGTCAATAA

GCTCAATAAT

GTGGTTACAT

ATATCACCCT

GTTCCAGGAA

TCACTCTGTA

AGTCCAGTAA

TGAACATGGC

rAACAGAAGT

ATGTGTCCTG

GTCCTCTGTT

CCCATCACTTr C1TGTCTTTrC

CCATGTCTGT

TACATTATTA

G3GCTAAGGAA TrTGT-rATCA

GCCATTCAAG

TATACTTACA

ATTTATCCAT

AGACAGTGTT

AGAGTGAGTC

TCYI1VCTCCC

CTTGTTCCCT

CTGCTTTCTA

=TrTrTCCC

TGCACATATA

TTATTATTGC

CTGGATTTCA

CCATGTATCT

ACTGACTTTC

ATITAAATAGT

CCATAATTCA

TCTACCTCAA

AGCTCAAATC

TGTGTTGGGC

TCACTACYIVT CTGGAACTGA CAGAGCU-GG AGAAACCTTA CACATAATAA ATATTTAATG AGTCCTCAT[ TACAGATACT TTGGTTTCT-r TGTTITAAA GTTCCCTGGG GCACCAATAC TAATTTCTCC TTCCCCTAGA 58 AATCAAAACA GGGTCTTATC ACCAACAGAA TAAGGACAGG TrGACCACTG ATTGTCAGAA TAUTGCTTCG TrTGTACTTT TAAGCCTAGA CAGTMTCAA TGACT1TTT TCTCTCTACA TGTCTTTTCA TAT1TrTATC TTGTTGAAGT CCCTCAGAAA CCTAAGGTCT CCTrGAACCC TCCATGGAAT AGAATATTTA AAGGAGAGAA TGTGACTCT-r ACATGTAATG GGAACAATTT CMrGAAGTC AGTTCCACCA AATGGTTCCA CAATGGCAGC C1TUCAGAAG AGACAAATTC AAGTTJTGAAT ATTGTGAATG CCAAATTrTGA AGACAGTGGA GAATACAAAT GTCAGCACCA ACAAGTTAAT GAGAGTGAAC CTGTGTACCT GGAAGTCTFTC AGTGGTAAGT TCCAGGGATA TGGAAATACA GATCTCTCAT GTGAGGGATG GCTCATCTGA AGATGGGAAA AAACAGGTTA TTCCAAGGGT TAGGACACCA GAGTGGGATT CAAGGCCTCT CATTf-AAG ACCCCTGCAT TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT CCCAGCACTTr TGGGAGGCTG AGGCAGGTGG ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA TCTCTGCTAA AAAATATATA TATATAAAAT AGGCAGGAGA ATGGTGTGAA CCTGGGCTAC AGAGCAAGAC TCTTCTACCC CCTTCCCTIT TCCTCCACCC TATT17CCTC CATATATGTG AACATTTCAA CTGCATAATC CATATGGCAG TTCCTTATGT CCTCTGTTGT CCAACAAATA GCATAGCATG TTGAATAG TGACCAATAG CCTCCATATG TAAATTCCAA CTAGAGAAGT CCTAAAGGAT 'I17CTCCTTTA ATGAATGCTT TGACTCATTA GTGACAAATA TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGAGGT GGAGGTTGCA GTGAGCTGAG TCCGTCTCAA AAAATAAATA AATAAATAAA TGATTACTrG TATGCC'TCT TTCAATAT[C TATCTTTTCT GCCTAGATTlC AGGTATATAT AGAGCTGTGT ATCTGGAATA GACCTGAATA TTAGGTTGTA TACTTAAGAA CACATATTTC CTTAGGCACA TGTGGCTTAA GTCTCTTTTA TACTCTATAT ACACAAACTA AAGCAATGTA TGGTCCTAAA YI'AATTATGC TTrAATTTTT ACAAAAGCAT TTJTGTTGAGT ACCTACCAAC

GGATCAAAAG

CTCTTCGTTA

ATGCTTGTIT

TTAGCAAATG

TTTTCTCTTG

GAATAGCTTC

TTATTATGCT

TAACCATAGA

TCCTAAGTAT

TCCCTGACTT

CCCAGGTACT CGGGAGGCTG ATCACGCCAC TGCCCTCCAG AAAGACCCCT GCATCTCT[ TAGTCATCTC TCAATATTAT TATGTGGTCA AACAGCATGA GTTTGACTTA AAGTTTTGCT TGAAACATAT CTGGGTACAT CATTTTTATC ACTCCTACTG TTGAATAAAC AAATTAATGA AGTGAAAAAA AATGTTTFCAA TTTATTCCCT GGAGTAGGTT AGCGATATTTr CCTTTCAAAA ATGTGATTCT TGTCT-rTCAC TGCTACCAAC TCCTAAATAC CYFGGAGCAC AGAGCAGTAT TGTGTTGGGC ATTCAGAATA GAATGTAGAA CTAGACAGGG GGGAAGAGGA CATTAAATAA AGAATTACAT AAGTAATTAA TTTAAATTAT ACATGTTT-rG AAGAAGTTTT 'FITTTGACAA CTATAATTAA CACTAGAACT GGGAAGTTTC TATAAGGTAA GAGAGGACAA AATAGACACT

CTCCTAAGCT

CTGAAAGGAA

CCCAGACTGA

CCCTTTAAAA

ATGCGTGGCT

GTTCTTCAGA

GTGCCATGGT

TGGTATGAGA

GCAAAGTGTG

GGAAAGGAAA

AAGGGGGGCA

ATCTCAATCT

TTTATGAAGA

AGATTGTGAT

GAAAAAAAGT

GCTGGGAAAG

TATGGAGAGG

AAGAGAGGGA

ATAATAATGT

TGAGACTGAA

TAGATTCCAT

GAMTAATTG

TAGCCAATAT

ATAAT]TGAG.

TTGGAAGGCA

GAGTAATAGG

GGTCTTGTCA

CTGGAGTTAA

TG17AATCTG

CTTCTCTTA

CATCTGTGTT

AAAATTCCCA AGAAAGACTG TTCTGGCTTT CAAGTGTrCC CTTT-TCAGGA GGGGAAAGGA ATCCACTTTA TGAGCCAAAA CTCTTTTCTC TATTCATTCT CTGGCTGCTC CTTCAGGCCT TGGAGGAACT GGGATGTGTA ACCACAACAT CTCCATTACA GCAGCTGGAC TATGAGTCTG AGCATCCATA GCAGGGGAAG CCTGTGATAC ACTGGAAAGC CTG1TTTCAAA GCCT-rGACTr TTAATGTGGT AATATTTGTG TACTAT11TTG ATCTCAAAGT TTCAAAGTTG AATGAAGAAA GAAACCAGCA AGTCAGTAAG GTAGGGAGGT GGACTGCCTC GCCTGTGAAG TATTCACT TTAAAAAAGC ATGAGGTCAA GTGCTATGTA CTTrGTCTCTA TAGAATCATT TGATAACTTA GTTTGGGGTG CAGCCTGGGT TGAGAATCAC T-rGTCTAGGT ACTAATCACA AAAATCGGTA ATTTAACTAG TGCAAMrCT CATTGATGAC CCCTGTCCTC TTrCGAATAA GGGGTTTATC G3AGGAAATGC T7AGGACTCC

TTTATTTTCC

ATGTATGGAC

T'TrATCAATA

AGTGAGTTAA

CTCTCTCTTrC

CTGCTGAGGT

CAAGGTGATC

AATGCCACAG

AGCCCCTCAA

CCTAACTAAC TAGAACTAGC AACAGAAGAT

TCATCAGGGA

CACAAGACAG

TGATAATTCA

ATTTATTGTT

GGTGATGGAG

TATJ7ATAAGG

TTGAAGACAG

CATrACTGTA

GGTCCGAGAG

GCTCTAAGCA

TAGTTTCTGA

kAATAAATAA

GGCCAGCCCC

ATGGTGAAGC

TGGAACCTAC

ATAAAAGGTG

GCT17GTGGC TTAT1TTGTG

CACATGCTCT

TGTAATGAAT

TCT-FCCTCAG

TCTCAAGTAC

TACTGTAGG

AGTTGGTAAA

GAAGAGAGAA CTTCTGAGCC TGAGCAG11TG CAGCTTGTAG CTACCAGACT TGCAATGAGG AGACCTGGGT GTTAAATGGT GATAGTAATA CCTGCTTGCA AAATGACTT-r GTAAACTGTT AAGCACTACC

CATCTGTTGC

GGATATAAAG

CTGTGTGCCT

TATGGCCTGT

TGAAGGAGAA

AATACATAAT

GGCTTCCAGT

AAAAATATAT

ATACGTATTT

GATCTTrAAA TCCTGGGGGA ACACTTATAT AGCTTGAGGA GCCCATTCCA GTGTATTGAG GGAGGAGGGA AAGAAAAACT GCTCTCTCCA AGTTAGACTT TTCC17CACA TAAGTCCTAG CAGTTCTCTG ATC'FrCATCT GTAAAACAGA TGATGCTCAT GTCTCATTTC TTCATAGGTC TTTCACATAA TGA'T1CTGG ATGTAATAT-r

GATAGTATAT

CTATGAAATT

CAAGCATAAC

TTATCAAATT

GCTTAGGAGG

ATGGACTTGA

AACTCTTTAT

CACITITGTAC

TTAACTAATT

ATATTTGGTC

TTGAGATTCT

TGGTAATGGG

CTGAGGCTCT

AATAATAGAA

ATGATTGATT

TGTGAATTCT

ACACTGGCTA

CTCAACCTAG

AAAGCTTGGT

TTTCTCAYJ7G

TTGGTGGTGA

CAGTrTATAA ACAGACTAAC AGAACCACAA TCATTT7GCC TAACAGGCAT GTAAGAAATG ACTTTGTCCC CMTCCACCC CTrAATTATA TTTCCTATTG TCTTCCCCTC TGGGCACGGC CTGTGGCTCC AGGGAGCACC AACAGAGCAL AGTGTTCT CTGTGCTTCT GOATOCCACA TCACGCTAAA AATGAAGGAC 3GGAGGATGA AACTCTGAAC CTCATTI7C. AGTTCCCAAG ATGAATTATG CCACTACAGC TCCGCGTGAG AAGTACTGGC TACAATTT-Tr TATCCCAYITG 59 T-rCTGTfTGC TGTGGACACA GGATTATTTA TCTCAACTCA GAGAACCAGG AAAGGCTTCA GACTrCTGAA CCCACATCCT TACTCAAGAA ATATTTGCAA CATTAG11'TT TTITCCAGCAT CTTGCAATAT ACATAGAAAC GTCTGTGCTC AAGGATTTAT GTTAAGTGGC ATGTAATAGT AAGTGCTCAA TTAACATTGG TTATTAGCAT TTGTAAAAGA GATGTTCAAT 'FrCAATAAAA TGAGTAUTCA AGGCTTGCTA GTTTGTTTGT TTGTTTTCTA GGAAATGTCC TCTCTTGACT ATUGCAAGTG CGATCTAGGA TGGATCATTT TTATGCTTCT TCTTCAGCTT ACTAAATATG GCAGCAGGTC ACATTTCTCT TGAAGATTAA AAGCCAAACC CCAAAAACAA CTGATATAAT CAGCAATTGC TACTCAATTG TCAAACACAG AGAAATGCTT CATTAAACTG AGTGAAACTG TrGAATAAAT GAGAGAATGA ATAGATTCAT TAAATATAAA ACCATGTAAC AGAATGCTTC CTAAAGGCAA GGACCATGAA GTTCTAGATT ATGAAAAGAC ATAGGAGGAT GCCAGTGAGG AACTTTCAGT TCTTGGCAGA ATCAGGGACA GTCTCAAGAC ATAGGACTCT CAGGATGAAG TAGAGTCCAG GATTccTCTG TGATTGTTTT GCCCCTCCCA AATTTATATC TTGAACTTAT GTCTTGTATC

GCTAATAATA

ACTAGACAGT

Tr1GTCATGGA

GCATGGGCCT

CTCCTGCCAT

AGTCCCTCAG

C'I1ACATGTA

AAGAGACAAA

CCAACAAGT-r

GCTGAGGTGG

AGGTGATCTA

TGCCACAGTT

CCCCTCAACA

TGGTGAUTCT

GATTAAGAGA

TATAATITACT

ACACAGCTrG

AAACTGGTA

ATAACCAAAA

TTTGGTTTAT

GTAAATGGGA

ATATTI'GAAG

GGAATCCCCT

AAACCTAAGG

ATGGGAACAA

TTCAAGTTTG

AATGAGAGTG

TGATGGAGGG

TTATAAGGAT

GAAGACAGTG

TTACTGTAAT

GTTTGCTGTG

ACCAGGAAAG

CAAGAAATAT

CAATATACAT

AGTGGCATGT

CCTTCGGCTC

TTrCCC'rrTC T-rAAAGTTC

CCTITAGATCT

ACTCTACTGT

TCTCC'17GAA TTTCT'FrGAA

AATATTGTGA

AACCTGTGTA

CCAGCCCCTC

GGTGAAGCTC

GAACCTACTA

AAAAGCTCCG

GACACAGGAT

GCTTCAGAC'I

YrGCAACATT

AGAAACGTCT

AATAGTAAGT

1TTATACAGC ACCTGAACCA AGCATTTrGG TGAAAACAGT CCAGGACTGA ATAAGATC11 A=IATGTC TTCATCATAG TCATTGGAGG TACTAAGAGT CTCCAGCATC CTCCACCTGT CTCCAGCACA GTAAGCACCA GGAGTCCATG GTGTAGCCTT ACTGTTCTTC GCTCCAGATG CCCTCCATGG AATAGAATAT HTAAAGGAGA GTCAGTTCCA CCAAATGGTT CCACAATGGC ATGCCAAATT TGAAGACAGT GGAGAATACA

AGAAATTCCA

GGGCAAAAGA

CTCA'FrCTTC

CTACCACCGA

AAGAAGATGG

GCGTGTfAGC

GAATGTGACT

AGCCT-rTCAG

AATGTCAGCA

CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGCCTCT

TFCCTCAGGT

TCAAGTACTG

CTGTACGGGC

CGTGAGAAGT

TATTTATCTC

TCTGAACCCA

AGTTTTT1TC

GTGCTCAAGG

GCTCAATTAA

GCCATGGTTG GAGGAACTGG GTATGAGAAC CACAACATCT AAAGTGTGGC AGCTGGACTA ACTGGCTACA ATTfTATC AACTCAGCAG CAGGTCACAT CATCCTAAGC CAAACCCCAA CAGCATCAGC AATTGCTACT ATITATAGAA ATGCTTCATT CATfGGTTGA ATAAATGAGA

GATGTGTACA

CCATTACAAA

TGAGTCTGAG

CCATTGTTGG

TTCTCTTGAA

AAACAACTGA

CAATTGTCAA

AAACTGAGTG

GAATGAATAG

ATTCATT-rAT TAGCATTTGT AAAAGAGATG TTCAATT-rCA ATAAAATAAA TATAAAACCA TGTAACAGAA

TGCTTCTGAG

ACAGCTCGGT

TJ7CCAGTGTG

TCGGCCTCAT

CACAAATTCT

CATTGAGGGA

TCTGGAATGT

ACACTGCCAG

CTATATCCAC

ATTGTAGTGA

CTGGGGAAGA

TACTTACAGT

AACACTCTGA

TfTCTCTCCAC

AAATGGCTGA

CT-ITCTCACC

AAAATTATGC

TITCTAYITCAT

TATGTATAAA

AGGAAATCCA

CACAGAAAGT

YTTTCTACC

ATTTAGGCAT

GTGGYITCTCT

GAAGCTCAUT

ACATGTGCTG

TAAAAAAAAA AAAAAAAAAA AAAAAAAA TCTCAATATA ATAATA1TrCT TTAT[CCTGG TAATGAAAAA ATGGACACAG AAAGTAATAG GAGAGCAAAT CFI7GCTCTCC CACAGGAGCC CCTGCATTTG AAGTCUTGGA AATATCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG CCCCACCACT GCATACATGG CTGACAGT[- TGAAAAAAGA GCAGGAGTTC CTGGGGGTAA GACTGCTATG ATATGCCTT-r GTTTTGGAAC AGTTGTCTGC TCTGTACTTG ATATTTCACA GACATTTT CATCATTTAA AGCAGGTTAT CCATTCTGGG GAGCCATATI' 'FI1TCTATT TGTCAATTAT ATCTGAAAGG AGAAATGCAA CATATCTGGT GAGAGGAAGC CTGGGAGCAA

CAGCATAGCT

ATCCACAGU'

TGATGCTGTT

ACTCAAAGGA

GAGTTGGAAG

TTCACAGCCA

AGCCTGCTGG

AYITGGGACAC

TTCTCAACTC

TCCAGGAGTC

CACAAGTAAA

GAGAATCATC

CCAAGTCTCA

AATAGGAGAG

GGGGGAACGG GAATITACCAT CCTGATCATC AACCTGAAGA GCCAGAAATT T17TTGAGACC AAGTGCTTTA TGGCTTCCT TCTCACCATT CTGGGACTTG GTAGTGCTGT GTCACTCACA AACAAGGTTC CAGAGGATCG TGTTTATGAA GAATTAAACA ACCCAGGGGA AATGTCTCCT CCCAYEGATT TATAAGAATC AGGATCCAGA AGGCCAAGGT CTTGTTAAGG GGCTACTGGA TTT AAGCTTTTCA AAGGTGCAAT TGGATAACTT AAGTGGGGAC AA'ITCCAGAA GAAGGGCACA TCTCTTrCTT

AGAGCTFTGGC

TJ7CCACTGAA

ATCTGTGGAG

TATATTCAGC

ACGTGTCCAG

AAAATTTCTA

CTGCCATGAG

TTCTGCAGTr CTACTAAAAT GTCTCATTT TCAAATrTTC

AGCCTGTTGA

AATGTCATGA

ATATAATAAT

CAAATCTrGC

TTATTTCATA

TCTTAATCAG

GGTAACCCAT

ATI7CTTTATTF

TCTCCCACAG

GAAGTCATAG

ATATATTGGG

TITACTCAGCT

AGTTCATACT

CATGCTTTTA

CAGGTTCTGT AAATCCTGCT AGTCTCAGGC TTAGTCTITA YITAGTAGAC TTCTCAATTT CCAAGAAACT TATCTGTCTG GCAAATGACT TTCAACTGCC TATITCAGAGC ATGCAGTAAG CCTGGACAGC TCGGTTAATG AAAAAATGGA GAGCCTfCCA GGTAGGTACA AGGTATTATT TCACGGTGCT TAGGAGATGA AACTT7ATTG TATGAGGAAG CTACTTGCTG TACTT-rCCAT TGCAAACTGG AAATAGATTT TCTCACATTA GTGTATGTAG ATCTCTGGCT TCTGGGTCTG TAAATACTTG ATAAAGTAAC CTGCTTCTTG CTCAGTCACT TGTGGCAGGG GGATCCATCT AGTTTAATTA CTCCCTGGAG AGGAAGATIT TTCTGGGTAT GAGACAGGAG AGGGACACAT ATCCTTCACA ATTGGTCTr ATAATCCATA AGCTGTGGGA TGCTTCTCTG AAGATGAAAA TAGTAATAGA GTCCCATCTA

GCTATTCAAA

TCAGATACAT

TCAACATAGA

flrGCTCCATfr

TGAGCTTTAG

CrCCCCTrrC AAT'FrCACAG

GAAGTCGGCC

GTGAGTGAGC

GCCATTCCTT

TTCTATGTTA

TGAATGAGAA

TTGTCCCATC

TTTCTTGGTG

TGTCTGTCGA

TGTGCCTGCA

TCATCCCCAC

CTCCTCCAAC

CATTGTATTC

AAAGGATTGT

AGAACTTGAA

TAATCACTTG

ATI7ACAATGA

GAATGTTGCA

TTJTGAAGTCT

CACTGCATAC

T17GACTAGA TGTGCACATG AAGTTGGGGT TTGTTACTGA CAAAATATAT GAGATOCATA GGTAAATGTG TUTATTTTCA GTTrACT[G CTGTTTTCCC ACT-rGGATTC ATGAGAGGTG TAACTGGGTC CTTTTGGGAA GAGCCAGAAG

GCCAACAGGA

TOACTACATA

TCTTATAGTG

ACGCAGTTTC

ATGAAATTCA

GTTGTCTGCT

CATTCTGGGG

TCTCTTTCTC

TATATGTGAG

GGGTTAAACA

TAAGGGCCAC

ACTATTCATC

CTGGGCATGG

AGGAGTTTGA

GTGATAGTGC

GTGAAGGATT

CATAAAGGCG

GCTAGGGTAT

TCATGTTTGG

TGTGYI7TTTC

CTGTACTTGA

AGCCATATTT

AGATCTAACC

CATATATAAC

TTTAGCCCAC

TTGACTAATA

AATAAAGTTA

TGGCTCACAC

GACCAGCCTG

ATACCTGTAA

CATAACTTTA

CATGGAGAAA

CCTGGAAAAT

CTTCTATTAT

TATAGGTAAC

TATTTCACAC

GTGAGTATAT

AGTTGTTTAT

ATAGATATGC

AGTITTTATCC

GTAATTGAAC

TATGATAAAT

CCGTAATCCC

AGTAACACTG

GATAGTGTTC

ALGATTTGAAT

CAGGGAGTTA

TGGAAATATC

ATGGCTGACA

GTAAGGGTTG

TTAGGTCCTT

CATTTCCTCA

TCTTTACYJ7A

AGTAUTGGCC

CTfACGTGTG

TAAAAAATGA

ACAAATTCTG

ATTGAGGGAG

ATCTATAATT

TCCCAGTATT

TCATTAACAA

CATGAGAAAC

CTAAACTTTC

ACATACAACT

AGCACTTTGG

GATTAAGAAT

AGGTGTTCTT

TACAGGATGG

CAGAATGTTC

TCCCCAGGAA

GTTTTGAAAA

GGTCTAGAAA

TAAAAAACAT

TAAAGACTYI7

GATGTAAAGA

TTCCATGCAT

GATCATTJ7CT

TACAATCTCG

ACTGCTATGA

ACATFF=rC

GTTTCTGAAA

AAGATGATAT

CAACAAAAGA

CTGAATCTAA

AGAATCCAAC

TTATCTGTCA

GAGGCTGAGG

AGGAAAATTT

GGTCAGTTAC

CTTTGAAAAA

TCATGACTGA

GTATCT-FCAG

AAGAGCAGGA

AGAATATTGA

GGTAGATAAA

AAAT17GCTAG

ACAATTACTG

TAGGTAGTGC

CAGGACAGTC

GGCATGGATT

TTGGATGCTC

ATAAACAAAA

ATTGCTTTTA

GCAGACTATT

GTTCCTGGGG

GTTGCATCAA

GAGTTGACAC

GACGAGAATG

ATGYJTCAACA

UTGTATCAAT

TAGGACACTA

GGAAAATTTTF TTTGATTTTC TATGCCTTTG TTTTGGAACA ATCATT7AAA GCAGGTTATC TAACACTGAA CATAGGTTTT TTATAATTFCT TAATTATAAA TTCTT-TTAC AATTAACGGT TACAAG1TAA ATGACTTGCC TCCAGGAACA TACTTCTAGC ACTAAAAATA ACAACAGAGG CAGGTGGATC ACCTGAGGTC ATATAAAAAA TTAGCTGAGT CTTGYITGAA CCTGGAAGGC AAGTGCGAAC TCTGTCTCAA AAAGAGATTG CTGGGGTGAG ACCAACATGG TGAAACCTCA TCTCTACTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG AGAGGTTGCA GTGAGCTGAG ATTGTGCCAT TGCACTCCAG CCTGGGCAAT AATAATAATA ATAATAATAG AAAATAAAGT TGTCYI7CATG AAAAATGAGG

AAACATTAAG

GTATCTCTTT

TTAAAGGTCT

GACACACATG

CT-rTGTAACT

GTGAATATAA

COCTOCACAG

T-rAAYI'CTAG

ACTCTCCTTG

TATrAGGTGT

TGACTTATAT

TATNTNCACA

GCTGATGGAA

CCTGATG11TG

GCCTCATGTA

CCCTCATATG

GAGTGCAATG

CCTCCCTAGT

AGGGTTTCAC

CAAAGTGCTG

CACTCTATAG

ACCCCAAATT

TTTfTCC

CAACATATCT

AGAGTCTTAA

TCTATMrGT

TAACATACAT

AGGCATATTC

ATCAATGGGC ATATGGTGAC CTTCTATGCC CTAGAAACTC TTTTANGGTA TACNCATCGT TCTATCTGGA AAAATAGGTG GATGAGTGAG ATAATAACGG AATTGACATA TATAAATTGC AAGTAT-rTCA GATGTCAATT TGCTAACCTT AAAACATCAC CACATTAATA CAATGTATGT ATCCATCATT CCAAAAGCTT CTTrCFCCT CCCTCCACTC CT-rGTCCTCT CGTTCCCAAG AAAACATTGA

TTTTCTCCTG

TATATACTTT

GACACACATA

CCCTGTGTAT

TCTGCTTCCT

ATTAACTTAC ATTTT'rrAGA GCTTTrATATA Y[ATTTTGAG ATTCTTCAAG TTTYrTCTTT ACTATGTCAC A1TGACTTTG TCGTCTGCTA AACCTGTACC TCTGTI7ANAT TGAAACTTGT CTCTCAACCC ATCAAACNCA CAATCTGAGT NTATATNAAA TNTGTAAATG TTTGGTAAAA TGATATATGT CAGACTCTGG AAATATGCAT GACNCACATA CNAATAGACG ATTGCAGTAG CTCGGACAGT TACTACNCCA AGAGTACCCC AATGAAGAAT TTFCATGCTCC ATCCAGGACC ATTCATATAC ACTTTTTJTTT TTT-rTTTITTA GCATGATCTT GGCTCACTGC AACCTCTGCC AGCTGGGACT ACAGGTGCAT GCCACAGTGG CATrTGGTC AGGCTGGTCT TGAACTCATG GGATTACAGA CATGAGCCAC CACACCCGCC AAAATAAGAA TAAGAAAATA TTGGGCTCAC TTACCTATGT TTGGAAGATG GGGTTAAAAG TCCTITGA ACAGT1TTCT ATTTCTGGAA GGTGAGT-rGC CCGTTTCTGT CT11TGTCCAT GGGAAACACA TCTTTGTCTC CTATATTACT GTCCTAAGGC TITFGCAAC AGAAGTTGGA GAAGTTrFATG TTTACCTTGA CGTTrCTTCTA ACATGATCAA ATAAAATAAT TAGTITITCAA AGTATGTTCT CTTrTACTGTT TGTCTTCCTT ATATCGATAC TI7CATJTCACA AGAATATATT AATCCTrAGT GCTCAGATGA C'FrGTTCAGG CTCTACTGTC ~T=ATTTC AAACACAGCT CMIAGGAGA TTGCTTTGAA TI-TGTGCTAT ATATCATCAT GTACNTTTTC ATAATTACGC GCCACAGACA CGTGTTTCTT GCCTAAAGGG AATGAGAGTG GTGGTCTAAN CAGTACATGT CTGCATTGTC AGGGTTAGCA TCTCCTGGAA TAATGAATAA GAATCTGCAT TrrAGCAAGA IATGGAGTCT CACTCTTGTC GCCCAGGCTG TCCCGGGTTrC AAGTGATTCT CCTGTCTCAG CTGGCTAAT-r TI-rGTATTI TAGTAGAGAC ACCTCCGGTG ATrCCCCCGC CTCGGCTTCC YI7ATTCGTAT ACNCATTTAA TTCTGAGAAG AGGTGACATr AATAAGTAAC TTrATCGAGT GACACA31'GA AAACAAGAAC TCATTGTGGC FGTTrGTCAAT TATATCTGAA AGGAGAAATG :CTTGAAAAG ATAAGAAGAA CAGAGTTA TGTGAATGTG GATATATGAT TF-rGTTrCAA TATATCA'rrA GAAACATAAA TTGTACCATT AAAAGTGTCC TACACCGGCA TTGTCCTITGT TTAAGGAGAA TATGAGGA AAGACCGTAC GTGTTCATGT GGTTCCTGAA GGCAGTCCAG TGAGAAAGTA ATATATGC~r 61 CATTAAACAA TGCGGACATT TTCAGGGTTT CCC'TTTfAA CCAAAATTTG GAAGCAATGT GGAATTTACT GGATGCATCC AGCCCTGAAA TGAAGATAGG TTTATTGAAT GTGCCAGCAA GTGCAGGCCC AGGTCTGAGT GTTCTTCATT ATTATCAGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAA'FrACCAT CCTGATCATC

AACCTGAAGA

TGGCTTCC17

AAGAAGCCCT

CTGTAAGTTC

TAAAGTTATC

GTGTGTGTGT

AAGAAAATAA

AAATTGTAGT

AGCTGGGGAA

GAATTGGAGC

CAAGTTFTTAT

CATAATAY[C

GCATGAGAGA

GAACTAGCCG

AAACCTCAGT

ACCTTTGATA

TCCATCTGTC

ACGGTGTCAC

AAAACCAGCC

CTAAAAAATA

AGGTACCTGA

GCAGTGAGCC

GGCCAAAGCT

TGTACTAAAA

AGOCAGGAGA

GCCTGGGTGA

GATAGATAAA

TTTTGGCCCA

CAGAGAGGT

GAAATTTGTG

TJTAAACATAT

AAGAATCACG

TACTGGAAAA

3T[TGTTTCT

TCTTGTTTTA

TTGATTATAA

ATAATATTrTG

CCATCCACCC

ATGCAAATAT

ATTGCCTGAA

TTATTAAG

AACA1TITCAC

AGTGACGTGG

AACAAATTAA

AAGGAGAACA

AGCCCUTTGG

AAACCCCGTC

CTACTJTGGGA

ACCAGTGCAC

AAAAGTCAGA

GATT-rTGGGG

AGATAAAAUT

CTAAGAGAAT

CTAAGGATAA

AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TUTTGAGACC TTCCACTGTA TGTATTITTTT TTTGTGTGGG AAGACTAAGA TTCTGGGTCC CTTCTCCTGT TCCATGAACA CCATCCT-TTT CTGTAACTTC TAITACACAG ACACAGCCCA GGGAGATGCT GGCTGCCCAC TCCCCTCAAC CCAGGCAAAT TACTGCAAGT GACGATCTCT GGGTTTTTCT GTGCCTGTGT TTGTGTGTGT GTATGTGTCA CYITAAAAGG ACTGGTCAGA TGGTAGGGAG ATGAAAACAG ACTTTTGGGG CGAATACCAA TGTGACTCTr TTTGTTTGTC ATT[G'ITGCT GATGATGCTG TTTCTCACCA TTCTGGGACT TGGTAGTGCT GTGTCACTCA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA ATCUTGAATG TTTATrrCCTT AAAATATGGC CTGGGTTTTC TGAAACATrT CTTCCAGAAA TACTTTGGTT TACAAATCTC ACATTTAAAT CACATTTTAT ACCATAAGTA CTCTGAATGA GGGTTGGGAT AATAGGACTG ATATGTTAGA AATGCCTTAA TGGATGTACA GAAGGCTTGT GAGGAAACCA CCCAGGTATC TGGCCTFTGTT CCTATTCCTG TTYFCTGTTTT ATTCCTTTGT TrCTTGAC'rr TTCCTTTCCA TTTCTTTCCT TTCTGATTCA TGACTACCAA ATGTTTTCAC TTGCCTCACC AGAACCACCA GACCTTGTGC TCATGTACTT GCCCATGTCT GATGGAAGAA CAC1TCCTG AGGCATTCAA GTCTAGCCAC CTTTTAAAAT CACTCTCCTC GCCTGTAATC TCAGCACTTr GTGAGGCTGA GGAGGGCGGA TCACTTGAAG TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA AATCTTAAAC CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA GGTTCCAGAT ACTTGGGAGG CTGAAGCAGG AGAATCGC1T GAGCCCAAGA GAGATCATGC CACTOCACCA CAGCCAGGGT GACAGAGCCA TACTCCCAG GAAGAATAAT TTGAGGTGAG GAThJTGGAGA CCAGCCTGGC CAACATGGTG

AAGTGCT-TA

TAATGTAAGT

TATAGTGGTT

TCCTCGGGGT

GTGTGTGTGT

GAGATGCTAT

GTTCAATAGG

CAATCTGTGG

ACAGGTTAAC

ATAGMTCTC

GCACACATTT

AGTGTGTGGA

TTCTGCCCCA

ACTTGCTCTA

CGTCCATTAC

ACATACTCTC

CAGGCTGGGC

TCAGGAGTTC

CAAATCTCTA

GCGTGGTGGC

GATGGAGGTT

CACATTGGGA

AAACTCCGTC

ATATAAAACT TAGTGGGGCI ATTGCTTGAA CCCGGGAGG CATAGTGAGA TrrCTGTCTCA TAAGACAGCA GATATACTA CTTrGGCCAGC TAGTCTGGTT GAGACCCAGA AAGACAAAA GTGATTGATA TGAAATGAT1 kTGGGGGCACA CACCTGTAAT YfCAGCTACT CGGAAGTTGCA GTGAGCCAAG ATCGTGGCCA AAAAAAATAA AAGAAATTTA AAAAATCACT AGGAATAACCT CACCAACTTG TCATTGACTG TGGYTF-CTG GAAATGAAAG AAATAATCAG G TAGATGAGGT AAGTCTCTTG AGCGAGACTT

TAGGAGGCTG

CTGCACTCCA

CTCTTCCAAA

ACATGATTTC

AG1TrAATGA

CTAGGGATGG

TTT7CCCTTAT CAGGTTCCAG AGGATCGTGT TITATGAAGAA ATTCAGCTAC TTACAGTGAG TTGGAAGACC CAGGGGAAAT GTCTCCTCCC ATTGATTTAT TGTCCAGAAC ACTCTGATTC ACAGCCAAGG ATCCAGAAGG CCAAGGTTTT GTI7AAGGGGC ATTTCTATTC TCTCCACAGC CTGCTGGTTT TACATTAGAT TTATTCGCCT GATAAGAATA GCTGCTTCTG TCCACCTTAA TATGCTCCI1T CTATTTGTAG ATATGATAGA CTCCTATTTT TATTATGACC ACACACATCT CTGCTGGAAA GTCAACATGT AGTAAGCAAG ATTTAACTGT CTGTGCAAAT ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG AGTTAAACTT TGACAGTTTG GTTCTTAGGG TrrTTTTTTT YTfAGCATT CTTrAATAGTT ACAGTrGGGC ATGATIrGTA ATACCCACAC AGTCACAGTC ACACACACAT ATGTATTACT TACACTATAT ATAACTTCCT TTTACCACCA GTCAATAATA CATTMTGCC AAGACATGAA GTTTTATAAA GATCTGTATA TCACCAGCAC ATTCACTGAC ATGATATTAT TTGCAGATTG ACAAGTAGGA AGTGGGGAAC 11TACTCGTTG TCTGGGGAGG TAAATAGGTT AAAAACAGGG AAATTATAAG TGCAGAGATr AAATGTTTAG TGAAACATTT GTGAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AAATGGAAAT AATGGTTATA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGATTTTGTTr AGAATAAAGT TAGACAAGCA ACTGGTTGAC TAATACAYFA AGCGT117GAG TCTAAGATGA CTGGTTrATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG AGGCTCACGC CTGTAATCCC GAGGCCGAGG TGGGCAGATC ACGAAGTCAG TAGTTTGAGA CCAGCCTGGC CAACATAGTG TCTACTAAAA ATACAAAAAA AAAATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG GGATGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC TCCAGCCUTG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAGATA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCATT TTTTrGGCTFrT AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC CAATACATGA GTTCTGGTAA TGATACACGG TITTGGTGTCA TTATAAGAGA AATCA117ATT AAATGAAGCA AGTTAACACT TATTTTGAGA TAGAAGTGAA GCTAAGCTAA ACTTrCACATG CCTATAATTG GAGGGAAAAA AATCTAGCCT AGAAGATACA ATAATTAGTC ATAAACATGC ATfTGTGAAAC TGTAGAGAGC 62 AGGTAGCCCA AAATAGAGAA AGATTAGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC UTGGGCAAGA GAAAAGTCCA CAGTGATAAG CAACTCCACC TAAGGCATGA ATATGCGGCA GAGAAAACAG

CAATAGTGAA

AAACATTTGC

TAGAAGGTAG

TTTTAGCCTA

ATGAAATAAT

AGATTGTGAA

AGGGCCTGAG

AAAACCCTAC

CACATCACTTF

GGATCCAATC

ATCATTGACT

TGCCCCACCC

TTFCACACTAT

CTGAATGAAC

GTATCATTAA

TGGAATAATG

ATGGGGAATT

AGCTCTTTAT

GCACACTCTA

TGAATGCAAA AGGTGCTGAG AAAGACCTTT AGAGAAAGAG TGAAGAAAAG CAAGCTAAGA

CAAATTCCAC

AATGGGAGCA

AAAAATTCTG

AGTATAAGAG

TACATTTTAT

AGTGATCACG

GTTTTCCAYT

CCTTTCACTG

CCATGGCATG

TATATC1TTA

ACATATTTCT

TACCTGCCT7

CACTGCCCCA

ACCTTCAT

TTATTAGTGT

TAACTTGATF

AAGGCATCAA

CAAACAGAAC

TAAACAACCC

TCCTACAGAT GGACTGAAAA GTATTGAGGA TGCCAAGAYF ACAATCACAC AACAAATAAT

CTCATTT-FTC

TGTATCATGC

GATGTTCACA

CAGTITGTATA

TATACACAAC

TTATAGTACG

AATTGTCTFTT

CCAGCCTTAA

GCTrGTGACC

TCTTATCTGT

TAAAATACAA

TAAGCTGCAT

TACAGACTCT

GTATATGATA

ACACAATTTA

CCCACCTCAG

CTAAATTTCA

TTTCTTGCTC

TCCTTFATGTA

ACATGAGTAT

TATGTGCGAA

TTTATAAAAG

AAATCAGTCT

AAAAGGTGAC

TAAGTGACYI7

TTTTGTTTCT

CTCTACTCTT

TAACCCTGGT

TCTCTTTTAT

TGAATTTTT

G3CAGACACAG

ACTTCAATGT

CATAACTACT

T[CTCAATTA

TGTGCATGAG

ATAAGATAGT

AAGGAAAAGA

GAGAGTATTA

AGGTAGATGT

GGTATGCTTT

CCAAATTTGA

GATCATCTGT

TTACCAGGAC

TCACTCAAT

CTCAAGATCA

AGCACAATGC

CATCTfrCTCC

CTATCCCACG

CCTGTATTTG

TTTAGGTACT

TAAATGAATA

TGATTATGAA

TAGTTTATGT

GTCACAATTA

TAAT-T[CCCT

ATTTFAATTGT

CAGCAGAATA

AGGTATTAAT

CTCTAGGAGT

TTATATT-rTC TTrCTGAGAGT

TGGGGTTCTC

ATGAAGACCA

ATGCAGTATT

TGCAATAAAT

TATCAAGATA GTTTGTGTTG GCATGCAAGA TAAAATGATG CCAAAGACCA AGAGCAGTTT CTGAAGTCCT CCTITrCATC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA ACAATCACCA ATAGCCAGAA AACAGAATGT AAGGACAATC AATTGATGGA ATAGAGTTGA AAGGAACTGG AGCATGAGTC ATATTTGACC TACTTGCTAT GTAAACTTGA GAAAGCYITTT TTCTCTTFTGT GAACCTCAGG AATTTGGAAC AAAAGATTCC TAACTGGTCT TTCTGFTrCCC ATATTCTGTG TFTGGTAATC ACAATTACTT AGTTTGTGGT TGAGATAGCA ACACGAATCA TITCAAAGGA GTAGCTCTCC AC'TrTGGGTA AAGAAGTGAT GCNGGTCGTG CAGCACTTTA GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA GGCGTGGTGG ACCAGCCATC T-rTTGTCAAT AGTCAGTCCT CACTCTTATT TTTTACATCT GAAAATGAGA ATTTTTCAAT ATITTAGGATT GAACTAYI'TG GTGGACATAT GTGGCTCACG CCTGTAATCC GACCATCCTG GCTAACACGG CGGGCGCCTG TAGTCCCACG TACTCGGGAG GCTGAGGCAG GAGAATGGCA TGAACCAGGG AGGCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG CAAAAGAGCA AGACTGCGTC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG TAGCAGGACA CCTGCAACAA TAATATTTTT CTAAATCCCT CTGAAAAATG CTAATCAAAG GGT~fTFT-C CTAAAAATTG TCY[AGAAAT AAAATTTCCC CMTGGGAGA CCGAGGCTGG CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTGAAACCC CGTCTCTACT AAAAATACTA AAAATITAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC CAGCTACTTG GAGGCTGAGG CTGGAGAATC ACGTGAAC GCCACGTGCT GCTGGGTCTC AGTCCTCCAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC AATGTI7GCGC TTGTACGTGT TGGTAATGGG AGTT-FCTGCC TTCACCCTJ7C AGCCTGCGGC ACACACAGGG GCTGCCAGAA GCTGCCGGTT TCGTGGGAGG CATTACAAGC GGGAGTTCAG GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC TGTCAGCCCC CGCATCAACC TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG AGAAGAAGAG ACACGGATGT GGGCCCAGGA CGGTGCTCTG TGGCTTCTGC CAGCCTrGCA GGAGGACTCT GGCACCTACG TCTGCACTAC TAGAAATGCT TCTTACTGTG ACAAAATGTC CATTGAGCTC AGAGTTTTTG AGAATACAGA TGCTTTCCTG CCGTTCATCT CATACCCGCA AATTTFTAACC TTGTCAACCT

CTGGGGTATT

CAAGGATTCT

GTACACGATG

AATACAACAT

TJTCCCCCCTC

ACCGGCACAC

GAGGCCGCGT

GATT[GAT

=ICAGACAC

AGTATGCCCT

CTJTCTITTTGG

TGGCCCTGGA

CACTAGGAGT

AAGACCATAT

CCTTIAACCAC

GACCTGAGTG

ATAAAGACAA

AGATGCTGGC

AYJ7GAGCTAC

CAGCTTCTCT

CATGCTGTGG

AATTCACCCG

TGAGAAAT'TT

TATITACCGCT

GCATCAAGAA

GGGGTCAAGA

TGGACGGCCA

TGACAAAACT

CTAAGTGTGA

GTGTCCTGAC

AAAAAAAGAA

CTGACAATCC

ATGACACCCA

AAATAATGAG

MTAAATGTG

CGT-rCTCCTG

GACGTGAAGA

GGGGGACCAC

AYI'TGCCCAT

GAGACCATTC

CGTGTAAGGT

CATAGAGAGC

AACTACATTG

1TGTCCATAA

GGGCATTGTG

TTCAATGGTA

TCACTTACTC

GAAGGCCAGC

CTGTGATCAT

GTTTCTGGGA

GCCTACCCGG

AAGTGCCATT

TACCCTGAGT

CTGGCCCCAC

GACCGAGGGG CCACGCCAGG AATATTCAGA CCTGTCACAA GAGAGGATTT GCACATGGAT TACGCACCAC AGTCAAGGAA GCCTCCTCCA T-rTCACTGGC CTFCTTGGTr TTGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT CAATCCTATC CCAAGTGAAA GAAATAAUTC AAACACAAAA AAAAAAAAAA AAAAAAAA GCCGGAGCCG ACTCGGAGCG CCGOGAGGAG CCGAGCGCGC CGGGCGCGGC GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG GAATGTGACA ATCGCGCGCC CGCACCGTAG CACTCCTCGC TCGGCTCCTA GGGCTCTCGC GAGCCGGcYTr CCGCCCGGGC TGGGATCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA GAAGATGGTG ACTCCCTCCT GAGAAGCTGG ACCCCTTGGT AAAAGACAAG GCCTTrCTCCA 63

CTGGAAAAGC

TAAATGGAAT

CGCGGCGCGG

GGAGCGGCAG

CCTCTGAGCT

CGCACCCTCT

AGAAGAATAT

GAAAGTGTrA CTCAGACTTA TTUGTTTCAT AGCTCTACTG ATTTCTTCTC TGGAGGCTGA TAAATGCAAG OAACGTOAAG AAAAAATAAT TYfTAGTGTCA TCTGCAAATO AAATTGATOT TCGTCCCTGT CCTCTTAACC CAAATGAACA CAAAGGCACT ATAACTrGOT ATAAAGATOA CAGCAAGACA CCTGTATCTA CAGAACAAGC CTCCAGGATT CATCAACACA AAGAGAAACT TTGG1TTTOTT CCTOCTAAGG TGGAGGATTC AGGACATTAC TArrGCGTOG TAAGAAATTC ATCTTACTGC CTCAGAATTA AAATAAOTGC AAAATrTGTG GAGAATGAGC CTAACTTATG TTATAATGCA CAAGCCATAT T[AAGCAGAA ACTACCCGTT OCAGGAGACG GAGOACTTGT GTGCCCTTAT ATGGAGTTTT TTAAAAATGA AAATAATGAG TTACCTAAAT TACAGTGGTA TAAGGATTGC AAACCTCTAC TTCTTOACAA TATACACTTT AOTOGAOTCA AAGATAGGCT CATCGTGATG AATGTGGCTO AAAAGCATAG AGGGAACTAT AC'rfGTCATG CATCCTACAC ATACTTFGGGC AAGCAATATC CTATTACCCG GGTAATAGAA TTrATTACTC TAGAOOAAAA CAAACCCACA AGGCCTGTGA TTGTGAGCCC AGCTAATOAG ACAATGGAAG TAGACTTGOG ATCCCAGATA CAATTGATCT GTAATGTCAC CGGCCAGUTG AGTOACATTG CTrACTGOAA GTGOAATGGO TCAGTAATTG ATGAAGATGA CCCAGTGCTA GGGGAAGACT AUTACAGTOT GGAAAATCCT GCAAACAAAA GAAGGAGTAC CCTCATCACA GTGCT-TAATA TATCGGAAAT TGAAAGTAGA TTIFATAAAC ATCCAT117AC CTG1T0TCC AAGAATACAC ATGOTATAGA TOCAGCATAT ATCCAGrrAA TATATCCAGT CACTAATTTC CAGAAGCACA TGATTGOTAT ATGTGTCACO TT0ACAGTCA TAATTGTOTG TrCTG1TTTC ATCTATAAAA TCTTCAAGAT TGACATTGTG CTrTTGTACA GGGATITCCTG CTATGATTTT CTCCCAATAA AAGCTrCAGA TGGAAAGACC TATOACGCAT ATATACTGTA TCCAAAGACT GTTGGGGAAG GGTCTACCTC TGACTGTGAT A'TTTTTOTT TTAAAGTCTT GCCTGAGGTC TTGGAAAAAC AOTGTGGATA TAAGCTGTTC ATT-TATGGAA OOOATGACTA COTTGGGGAA GACATTGTTG AGGTCATTAA TGAAAACOTA AAGAAAAOCA GAAOACTOAT TATCATTMA GTCAOAGAAA CATCAGGCTT CAGCTGGCTO GGTGGTTCAT CTGAAGAGCA AATAGCCATO TATAATGCTC TTGTTCAGGA TGGAATrAAA GTTGTCCTGC TTGAGCTGGA GAAAATCCAA GACTATGAGA AAATGCCAGA ATCGATTAAA TTCATTAAGC AGAAACATGG GGCTATCCGC TGOTCAGGGG ACTTTACACA GOGACCACAG TCTGCAAAGA CAAOGTTCTG GAAOAATGTC AGGTACCACA TGCCAGTCCA GCOACGGTCA CCTTrCATCTA AACACCAGTT ACTGTCACCA GCCACTAAGG AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAGTT GCCAAGAGTT CTTTAGGTGC CTCCTGTCT-F ATGGCGTTGC AGGCCAGGTT ATOCCTCATG CTGACTTFGCA GAGTTCATGG AATGTAACTA TATCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG-3'(SEQ.ID NO:3002) Human Enzyme-related Antisense Polyvnucleotide GCT CCT GOG GGC CTC CTG GTC CCT CTG GCT G TT CCC GOC CCT GGB CTG GOG CBG GOG CCG CGT BGG CGC GOC TCG CCB 0GB CGG GCB GCG CCB GCB 0GCB GCB OGC TCB GCB TCC TGG CCB CGG BBT TCC GGT GTG COG GGC CTG GTG CC CCT GOG CCT CGG GTG CTG CCT GT GCG CTG CCT TCT TCT CCT GG OTC CTC GCC GGG GCC CUr OCT 0CC CTG GCT GT 0CC CTG GGG GTC TOG GTT COO CTG T CCC CBG CBG GBC CBG TCC CBT CCB CB0 COT OTG BTG BGT BGC CBT TCT CCT GCB GCC GBG GOG CGC GOG CGB GCB TCG C TTT 000 CTT UTC TCC UTT GGT T TOB GCG CCB GGB CCO CG BCB GCB GCB GGG CGC GO CGB OCB TCG CBG COG CGG GCB GGG GGGCTCCCGC CGCGBGBGGT TBTGGOCTCC CBGGBCCBCC CGCBCCOCOC GGBCOTTTBC BT-7CGCCBCG CBGTOCGCGG CCGBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB GBBGTGGCCT CCGCGCBGCT GCBGGGBCBC CBTGBBGGGC CBCGCGTGGG OCCGCGCTCG CCGGCCCCCC BCBBTCTCCO BGGCCBGCGC OGTGCCCCCC BGCBGCBBGG CCGGCBGGBC BCBGGCGBGG BGBCBCGCGB OTCGOCGGCC GBOOGTCBTG OTGGOCTOG OOCTCCGOGO TCTCTGCCCC TCCGTOCTOG TGGOCTOGO GCTCCGOGG TCTCTOCCCC TCCOTGCCGC GTOOOGCCOC GCTCOCCGOC CCCCCCCTGC CGOTGOCT CCCOCCGCGC GCCGGCCTGC CGGCCCCTCG TGGOTCCTGC TOGCCGGGTC CGGGTCCCGO GOOTOGOGCO COBGTCGGCO GCCGBGOOTC CCCTCCBCBT CTGCTCTOBC CTGCTGOBCT CTGOBTCTGB BGBTBCOCCB TGTBGOGGCG GGBOTGOOGC CTOCTCTCCC GGCCTCCGBT GBTCTCCCCT GCCTCBOCCC CBOTGOTBO OBOBBBOOCC BGCBGBBGCB GOBOTOOCTO CBTCUTTCCT GGTGGGGCCT GCTCTCCCOO CCTCCOTGTG U-GCTOGOTO TTTTCCCGTC TCTGOTCTGC CUrCGOOT COT CCGOGGCTOC BGCBBCCTCB TCBGCTCUOG CCTOOBOTOG CTCBOCCTOO OCCTGCBGGG CCBCCBGGBG BBTGOCBGCB BGOBTOGCOB OOOTCCTCBT GOCTGGOOTC BCBOBTCCTC TBGCTBGGCB OOOTOBCCBG BOGOOGC GO TCC TCB TOG CTG 000 0CC TOO 0CC TOC BOG 0CC OCT CTT 0CC TOG ROT OOC TC 0CC CR0 BOT CTT CCC TOG T COCTGCBBTC TGCTCCGOOO CTOCBGCBBC CTCBTCBOCTC U-GCCTGGBGTO GCTCBOCCTOO OCCTOCBOOO CCBCCBOOBOB RTGGCBGCBBO OBTOOCOBOOG TCCTCBTOOC TGGOOTCBCCT OOBGBOOB GBGCBGGGGG TCCTCBTGGC TOOOOTCCCT CTCTCCCGTC CT COG TTr CCT TTG COO TC UrG 0CC COO OCT CCO GOT 0 CCC 0CC COC CCO CCO 0CC 0CC GC CCC 0CC 000 CTG TCC CCO CCC COC CCC O0C CCO 000 COC 00000G COG CCC TCC COC CCC TCT 000GCC GOC OCO GOC OTC GO CCG CTC OCO CCT 000 GUT CCC TCT CCT CCC CCT OTO C 0CC TOC CTC 1170 CTC T-CTGC OTC COC TOC CU- CTC CC CTC TCC TCG 0CC OTT 0CC TOT GC TOT CCO TCC TOT COC CCT TCC OTO OTO C TOT TOT CTC TUC TOC CCT C OOT OTO CTO OTO CTG OTO OTO OTO CCT CTO CCC OTO CTC GCCCTG CCT 000 CTG 0CC TCT TCO GOT OTO OCT TTO 000 CTC TCT TOO 3170 CCC TilT CUT CTC OTO OTO CCT CTC CTC CCT GOC TTO GTC OT TOT CTG 000 TOO TOC TCC TCT CCC TIlT CCC TOC TOG CCO TT OT CCT OTT UTC TOT CTT CCT CT THG CTC CTO TTT CTG COT TTO OCT TOC TOC ITOG COO O0C TOT CTC C CUr 0CC CCT OTO GOC UTT CCC TOG TCC GOT CUT CTC CUT 000 GOT C 0CC CU- CU- GOT 000 CTOOCT GT CTG TCT TilT TCC U-C C TOO 000 TOO CCO UOr TOO OCO OTO TOO TCC 0CC T TOC CTC TOC TOO TCT UTC CTCOGTBOBC GCOCTCGBBC TCGGGTOGGC COOTOOTOBO CGGCGGCGBCB CGCGGBBGGC CCTGCGCGCC GBGBTCBCCTG CBGGGBGBBG TBGGCTTGCB GCBGGBCTCC

CBGGBGGGTG

TGTGTGBBGG

GGTGGCCTCG

CGGCCCGGGG

TGGGTTTCTC

TFGGCBBGCC

CCTCCCGTTC

TG'fTGCCTTT

CTCGGTTGTG

GTTCCTCGTG

TCTTTTCCTG

GTTTCTGCTG

BGCBCBBGBG

GCTGGTTTTC

TCTCGCTGGT

TCCTCTTGCT

GTCCTITGCCC

CTCCTTTTCC

TrcTcCTCT TfrGGTGCTTG

TCCGTCTGCT

GGGGCTGTGT

GGCGTCTTGG

CGGTTGCCCC

TCCGCGTGGG

CGCCCCCCCT

GGCTCTGGGC

CCGCCGCCGC

GCCTTGGCGC

GCTGGTGGCC

TGGGCGGGCG

TCCCTGGGCT

CTGGGCGTTC

TCGTCCCCTC

GGCCCBTCCT

TTGCCGCACG

CTGGGGGCTG

CGCTGTTCGT

TCGTTGGCTG

GCCTTGTCYT

TGCCGGTGCC

CGCTCTTGTG

CCCGGCCTCC

CCGGCCCTCG

GTCCTGTGGT

CCCT-rCTCCG

TGGGTGCCGG

CGCTCGTGTC

CGTTTTGCTC

CCCCGGGGTT

GGTTCCTGTT

TCTCGTCCTG

CCTCGGGTGG

TGGGGCCGCT

TGTGCTGGGT

CTGGCTCCYT

GCCGCCGCCG

AGAGCAAGGC

CATGCAGAAG

BCBGCBGCCB GTBGBGCTBC CTCGTCCTTC BTGGTBCCGT CGGTGTGGTG GCBCGGGCTG CGBGCTGGGC CCCGTCTGCT GCTCCTCGTG CCGCCTCGTC CTTCA TGG TA CCGTCGGTGT GGTGGGCCGG TGGTGGGGCG CGCGCGCTCG CGTGGCTCCG GCTCTTCTTT CCCGGCTCCGT GCCTTGGTCT CCCTCGTCCT TCBTGGTBCC G BCCGGCGGBG CCGCCBGGGT GGBCTGGGBG

CCCGCCGYJTC

BCBBBCBGCB

CCCGTTCGCC

GTGGGCTTCT

GGTCCGCTGG

GGTTTCTCCC

CTTGGCGTCT

GGBGCTGBTB

BBBGBGCBGC

CTTTCCBGTC

TTTCCTTTCC

CTGGGCTTV17

TGGCCCTCTT

TCCGCTGGGT

GTTGGCTGGC

TCBCCCBCCG

GBGBGBBBBT

TGGCGCGCGC

TGTCTTTTTG

TCCTTTGCCC

CGCCGTTCTC

TTI'CCTYITCT

CTGCBGAT

BGGGGGBGBG

TTGGGTTTTB

TGGCAGTGGG

CTCCCCYTM

CCCTCTCCTG

GGGGCCCTGC

TTTCTCCTTC

CGCTGBGCTC

CBTGBGCBBB

TGCGGGYTCC

GCTGTTCTTT

TGTGTGTTTC

CGGTCTGTTG

TTGTGCTCGG

CBGBGGGBBG

GBBGBBGCBG

TBBCTCCCBG

TGGGGGTGGG

CCTfCCTGTC

TCTCCTGTCC

CTG17CTCTG

TTTTGTCTTC

BGCGCCTBBG

TBBTCCBTTC

TCGTGGGTTT

TCCTGCTTGG

TGCTGCCCGT

CCT-rTGTGGG

TTGTGGGTCC

BBCCCTGBTB

CBTCTTCCCB

BBGGCBBGBG

GGTGGGGTGG

TGTTTTCCTG

CTGTGTTCCG

CTCCCTGGCT

CTGGGTGCCC

CBTCCTGCTG

CGCACGACCC

GGGCTGGGTTF

GTTCGTGGGC

TGGCTGGGTC

TGTCTTTCCG

GGTGCCCTTG

CTTGTGCTGT

GCCTCCTCCT

CCCTCGGCCT

TGTGGTCCCC

TCTCCGCCGG

TGCCGGGGTC

CGTGTCGCCC

TTGCTCCTTC

GGCTGGG GCGTCTTGGG GTGCBGGGCC BCTGCTGTTT CTGGBGCTCC TGBBBBBBBG GGBTCBBBBB CTCCCCGCCG TTCTCCGGTC CGTCTTTTCC TT-rCTTTGTG TCGCCTGGCG CGCGCTGCGG CTTCTTGTCT TTTTGGCTGT GCTGGTCCTr TGCCCTGTGT CTCBCCBGCT TCBGCTCTGG GBGBGGCTGC CTGBGCBBBT BGGGGCBBGG CGT1TTTCTTC CTTCCTTGTT CCTGGGGGTG GGGCTCTCCT CTGTCTCTGT CCCGTCTTCC CTCTCCTGAC TGGGGTTTCT TCTGTGTGTC CY7CTTCCTT TCTTGGGTCC CGCCTGGGCG CTGCTGTGCG CGGGCCGACC CGAGGCTCGG TCCTGCTGCG CCTGGGCGCT CTGGGGGTGC CTGTGGCTGC CCCCCGCCCG TTTCCTGGGG GCCGTGGCGG CGTGGTGGTC GCGGCGGTCT TCTTCCTGGT TCCGGCCGCT CCTTrCCTCUT GGCCGCTGTC TCGGGCGGCG GGGCGCTCTC TTCCGCCTGT CGGCTGGTGG CCGGGCCGGT GGGTCCCGCG CTCCTGCTGT TCCGGGCTTG CCCCGCGCTG TCCGTCGCCC GTCGCCGGCC CTGGGCGTCT TGGGGTGCBG CCGGGGTGGC TGGGCCCTGC GCTGGTGGGC 'I17GGGCCCCT GGGGGGCCGG GGTGGCTGGG TCTGGCGCTG GTGGGCTTGG GGTGCGGGGC CGGGGGGCCG GGTTGGTGGC GCCGTCCTGC GTGCTCCGGT TCCTCGTGCC GGCCTTCTGC TCGGGGTCTG CCGGCCGGTC TCGGGCGTCT CGCTCCCCGC CCGCTCGTCG TCCGTTTGGG GCTGCCTCTG CTCGTGGGCC CCTCCTGGCC TGGGCGCCGG CGGGTCCTCC

CCCTGCTTGC

GCCCCTCTGG

GGGGGCCGCT

TGCCGGTCGT

GCTGCTGCCT

GCTGGTTGCC

CGTGTTFCGCT

CCCTGGCCCG

GCGCTTCCGG

TCCGGTGTCC

GGGCTGCCCT

CTTCTGCCTC

TGCGGTCTTG

CTGGGTGCGC

TCTCCTGGGT GGGTGCTGGG GGOTTGTCTG TGGCCCCGCT GGCGGGCTGG TCCTGGCGTT GCTGCGCCTG GGCGCTGCTG TGCGTCCGTC TGCTGGGGGG ACCCCGGGCC GACCCGAGGC TCGGGGGGCT GTGTTCTGGC GGTTJ7CCTGC TGCGCCTGGG CGCTGGCGTC TTGGGGTGCG GGGCCGGGGG GCCGGGGGGC

GGGCCTGGGG

GGTCCCCCCG

TCCGGCCGTG

CTTGGCGGCG

CTG'rrCCGGC

TCCTGGCCGC

GCCTGGGCGC

CCCCCGGCTG

CCGGGGGTCC

GGTCTCCGGG

GCCCTCCGTC

CYTCCTGG

TCTGCTGCTT

G'TTCTGGCC

CCYTMCCTG

TGCGGGTCCC

GTGCCTGTGG

CCCG1TJ7CCT

GCGGCGTGGT

GTCTTCTTCC

CGCTCCTTCC

TGTCTCGGGC

TCTCTTCCGC

GTGGCCGGGC

CGCGCTCCTG

CTTGCCCCGC

GCCCGTCGCC

CTGCCCCBGT

GCTGCTTCTT

TGCTTGGTGG

TCTCTGTCGC

GGTGCTCCCC

CTGCCGGT-fG

GGGGTCCGCG

GGTCCGCCCC

TGGTGGCTCT

TCT-rCCGCCG GGCGGCC1TG

CTGTGCTGGT

CGGTTGGGCG

CTGTTCCCTG

GCTGCTGGGC

GGCCTCGTCC

CCCCGGTTGG

TGGGGTGCTC

CCCTGGCC1T

GGGCCCGGCC

CCGCCGCTCC

GCGCTCCGTT

GGCCCTCGTG

GGCGTGGGCG

GGCTCTTCTG

GTTCTGCGGT

CCTCCTGGGT

TGGCGCCGTC CTGCTGCCGG CGGTTCCTCG TGCCGCTGCT CTGCTCGGGG TCTGGCTGGT GGTCTCGGGC GTCTCGTGTT CCGCCCGCTC GTCGCCCTGG TGGGGCTGCC TCTGGCGCTT GGCCCCTCCT GGCCTCCGGT CCGGCGGGTC CTCCGGGCTG CCTCTCTCCT GGGTGGGTGC CTTGGGGTTG TCTGTGGCCC GCGCGGCGGG CTGGTCCTGG GGGGBGGBCB BTGGCTGCCT GTCTCCTTTT TGCCTC1TTIG TCTTCTCTTG GGTCTCCGCT CTCCTGCCCT GTGCTGTTTG TGGGCCTGTC TGGTGGGGTG TGTTGGTGTC TCTGTGGGCG CCCCCTYUCTG GGCCGGTGGC TTTTGBTCCT CBCBTGCCGT TCCCGTCTCC CTrCT-rTCCC CGGCTTGTGC GTCCTCTC GCCGTTCCTC CTCCGUCGTC CGOCGGGCCG GCTGGTTGCC GGGTTGGGGG TGTGGTGGGC TCYJ7CTGTGG CCTGTGGGGC CTTGGGGCTT CCTCCCTTGT GCTGGGTGCG GCCTCCCCGC GTGGGCGCTT CTGGCTCTTG CCCTGTCCTT CTTCGCCTCG TGGCTGCTGG GCTGC CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG GCCATGGAGA CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCCCAGCA TCCGCAGTGT TACCTGGAGG ACCGGGGCGA GGTGACCTTT GAGAAGATCT TTTCCCAGAA GCTGOGGTAC CTGCTCTFCC GAGACTTCTG CCTGAACCAC CTGGAGGAGG CCAGGCCCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGCTCGCA TCCCT7CTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC T-rCCAGCCAT ACATCGAAGA GATTTGTCAA AACCTCCGAG GGGACGTGTTF CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGGTTI'TGC CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACUTCAG CGTGCATCGC ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG GCCCTGAACG AGCGCATCAT GCTCTCGCTC ATTCATTGTC TGCATGTCAT ACGCGTTCCA CACOCCAGAC AAGCTCAGCT GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTr CGTGGTCTAC CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGiGCCTGG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCTCT[ CAAGTTGCTG

GTCAGCACTG

TCATCCTGGA

TGACATGCGC

CGGGACCTGA

CCTGTGACTT

GCAGAAGGGC

CGGGGGCACA

GGGACTGCCC

CCTCATGAAC

TTCTATGCGG

AGCCAGCCAA

CTCCAAGAAG

GTGGCCTACG

GCCCCTTCCG

GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC TCCT-FCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTT TTTCCGCTCC CTTrGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG GAGGTGAACG GGCTCCTTCG ATGAGGAGGA CACAAAAGGA ATCAAGTTAC TGGACAGTGA TCCCCCTCAC CATCTCGGAG CGGTGGCAGC AGGAGGTGGC AGAGACTGTC GACAGACCGG CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTT GGTACTTCTA CCTGTTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG TGTCAACCGG AGATTGGGCT CTGGACTGGC AGATGGTCTT CGGCCGACGC CU-CGACATT TCAGGAGCTC TACCGCAACT TTCGACACCA TCAACGCTGA ATGAGGAAGA CTACGCCCTG CCTGACCCAG TGGCAGCGGC GCCCCGCAGA GCCTGCTGAC

CATGGAGGAG

GGTGGGAAAC

ACGCCTACCG

GGTGGAGCTG

CCAGGAAGCT

AAGGGCTTCC

TCCAGGTGCA

CAGATTAAGG

CTCTCCTCTC

GATCTAGATT

AGAAGTAGAC

ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC AGTTCATTT[ GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTI'GT CCACGGAGGA AGGTACACAG AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT GGGTGAGTTG GTGGGGAAAC GAGGATGGTA GCGAAACAAA CTGGAGCATT AAGGTCCAAG TCCTCCAAGA TCTTGACTTG AGFTGTTCA CCTAATCTGC AGTAGCCCCA GAAGGCCTGG TGGGAAAAGC ATCCCTGGTC AGATTCACGG AGATTCTCAG AAGGGGAGAG AATGAAGGAG CAGTTGGGGT TGACTCACCA CCCACTGAGA GGAGAACCTC TGATCCAAGA TGGTAGCCTA GAGGTGCACA GCCCACAGCA TGGTAATGAG A117TGAGCTT AGCAAAGAGA GGCTCTAGAG AGGGGCATGI CTCTGGGTGG CTCTCAGCAG GGTGGGTTTC GGAGAGTTTT TACCGTAACT ACATGTGGAA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC GGTACTTGAT CCTGAGTGGG CCTJTCTGCGG TTTGGGCAGA GTGTGGTGAG TCCTAGAGAC CCCTCTAGGT AGAGCTGCTT CTGGGTGCCA AGCAGGCAGT GACTCCATCA AGGGCCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG GAGGCCAGAC AGGAGACTAT GGTGACAAAT TAGATTAGAG AAAAGAAAAC TGAGGCTGAC ATGGGTATAT GGGTGGCGAG ACAAGCTCTG ACATGCTCTG GTTCCAGGTT CTGTTGGGGC GAGATGGGGG CC17GCTTTG CAAAAGGATG CTGGCTGCTG TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACTTTGAA TGAGATAGGA ATGCTGCCTT GAGACACCTG GCTTrCCCCA CCCTGCCAGG CAGCACTGAA CCTCTGTGCG CYJ7CCGGCTG CCATCCTGAA GGAACATCTG GATGGGATGG GGTACAGGGA CTGGGTCTAT GAGCTGGTTG GGGGGTGGGG TTGGGTGCAG CCAGGATTGG TTCTAGAGTA GGAGGGGTGG GATCGGGGAT CAGGTCCCAG GTTCTGGGTG ACCTACTAAG GATTCTGGGT TCCTGAGTCC GTGTCCACAG TTCTGGGTGT TGAGTCTAGG GGTCTGAGTC CTGACCCCAA GTCTAGAGTT CAGGGTCATG GGTCAGTAAC CAGGATGGGA TCGAGGTCAT GGTCCAAAAT GTGAGTGTCG CAGTCTGGGT ATGGCGTTGG AGACCCAGGG GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTGT31TGGAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTGTCTTGGT GAGCGTCCAG GTJTCCCTGTG ATCACGTTTG TGGGATCCAG AGATGTGACC CGAGGTTGTG GTCAGAGAAT TGTCGTGTTC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG GTCGCAGGTC TGGTTCGGGG TCAGATTCCG CGCGGCCTCC CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGGGGCCG GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCGGCG

GGGGGAAGCC

CCAGTGTGGG

ACAGTGATCT

GTAGTAGCCT

CTGGATCTGG

CTGTGATCTG

TCTGGTGTCA

GTCCCAGATG

GTGTCAGGGC

GGGTCTCGGG

CCGAGGTCAC

AGGGGGCGCC

GAGGCGGCGG

GGAGCGGAGC

GCGAGCGGAG

CCGGGCCGGG

GCCGCCAAGA

AGGCCACGCC

TCCCAGYI7AA CCAT"TCTrTGA

GCATTTCCCA

TITCCAAATGT

CTGTAGCCAT

ATCTACCCCA

AATCTCCTTG(

CCACAATATG

AGTTCC1TTTC

ATCAGGGCTG

ACCCCTGGGA

CATCATGGCT

TGTAACTGCG CTGCAGTTGT

TCCCAGGTTA

GGAGTTGACA

AGGGTCAGAA

GGACCTGTTG

AGGTCATGGT

GGTCGTGGAC

GTGTTCAGAG

TGCGGCCCGA

TCGTCTTCGiT

GGCCAGGGTC

GTCGCCGCCC

CGGCTCCGGG

GACGTCCTAG

GTCCAATCTA

TCAAGGTTGG

GGGGTCTGAG

TAGAGTCTCA

TGCGTCCAAG

GTCTGAATCT

CTGGGGAGCC

GCCGGGTCCC

TGAGCCCGCG

GGCTCGGCCC

GGCGCGGGCC

GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GTGAGCGGCG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC CGAGGCCGAG CGAGCCGCGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG CGGCGGGAGG AGGCAGCGCC TGGCGGACCT GGAGGCGGTG CTGGCCGACG TGAGCTACCT GATGGCCATG GAGAAGAGCA GGCCGCGCGC GCCAGCAAGA AGATACTGCT GCCCGAGCCC AGGTGAGGAG AAGCT TACATAATCA ATATGCAAITr TAT7AATACA TCTCTCCATG CCTGCAT-rTC CATCCTCCTT ACCTTCCCTA GAGGCCAACT GAAAAAAAAG TGAAGGGCTG GGAGCTGTCC GTTGTCCTGA GGTTGGAAAG AAGCACTATr GAAAAATCCC TAAACGCACC GGACACATGC TGTTGATACC ACCTGCCTCA TGAGTCTCAC TCAGCCTTAC CAAAACCATA CCTGCATCCT GGGCAGCATC AACCAAGAA TGACTAGACC AATGAGACAC CC1TTAAGGC GTAATCCCAG TAAGGAGCTA TCAAGCCATT GCAGGACCAT TCCACTCCCC CTGTATCTTG CATITCTTT GAAAAACCTG TTTGCTCCCT CTGCCCTFGC CCTGCAGGGT TGGCTCTACC ATAAYITTGCC CTTCACACT TGCCCTJ7CAA GAGACTAAGG CCCAGCACAA TATAGAAATC CTAGAATACA ACTAGAGTAT ATCCAGGAA CTATACTCTA ACAGCTTGGC TCACAGGAAC CAGAAGTGAA GATGATGAGG AGCCTGTGAG CACCAGCTCC ACCACTGACA CCAACCACAG ATTAAACAAG CATCTTGTGG TGGAAAGAAT AGTTGTTGCC TTATCAACCT CCCCCACAGC CCACACAGAA AAGATAAAAT ACAGTGTTAC AGAAGATGAT GACCCAAGGA GTAGGCCTGC CTGAGTGAAT GCTGAGAGTG ATAATGGGAG CAGTAGCATC TCAGAGACTA CAGCAGAAAC CATCCACATA AAGAGCTTTG CCCAAACTTA TGATAAAGGG CACCCTCAGA GACTCTCCCT ACTTTAATAT TAGCCCATTG CAGAAATGGT GAGTGGAAAG AGAAATCTTA GGAAGAACGC CTTAAAAAAG CAAAATGCTT AAATAAGGAC ACACACGCTG AGAAATCT-rC CTCCTGCCCC ATATCTCATT CTCCTGGATA CACTGTCCAC TCAGAAATAT TATTGTGTTA GGAGTGAAGG CAAGAGTATC GTAAAATAAA TTTATAGATG TTTAATGTAA GCCAGCAGCT ATTAAACGAT TCAGAAACTA TAGAAACAGG CAGGACTTAT TGCGAGGGCA AAAATCTGCC AGTGCCATGA AGGATGTACT CTGTCTGCTC CCATCAGCTG TCCCTGACCC ACAGGAGTTC TTTAGAAGAG ATACCTGCCA ACTCGAGGGT TAAAACAAGT TGCATAGAAA CAGAGAATAA TAAACAGCCT GGCAGCACAT GAATGAATAG AACCAAATTC CATAACAGAT GUTAATCTGT AATGTGTTTA CTFlTCATCAA AAAAATTATA GCCAATGAGG ATATATCTAT ACAAGGTAAA ACACAAAGGA ATAAAACCAA CGTrATTFAA ATCATATTTA AYITCTGAAAA AAATCCTTGT ACTGTATCAT GCTGAGAACT TTFAAAATTTT TCCTAAGTTC AGACACATAG CCCATCTAAC TGCAGAGCAA ACTGCATGCC TITAAATGTCA TTGGAAACTC AGAGAAGGAA TGATCCCTCT GCATTATAGT CCAGTGC11TC TACATCAGGC CCAAATTTTC TGTCCTACTA CTTGAGTATC TGCCGCAATG AGAAATCACT TACCTCCACT GTTAGTAAGT CCTfTCTTAT ACATACTCAA CAGCTGCTTC AAACTAGCCA GAAGCAATGT CCAAAATACA CCATAACACT GGCCCAAACA TTCTAGGCAG CACTGGATAT CTGAATCATC CAGTCACCCT CACTAGAAGA ATTAATTCCA CATGATAATA TT1TAGGTTTG TGCTGAAGAG CCTGGAAAAG AACACTGGGA TAATCTCCAA GGATCTCTCC TGTGCAGAGT GCAGTAATTC AAAAGTGAGC

TCAAATTTGA

AAACCTTAAA

AACACAGAGT

CACTGCACTA

ACTGGTCAAC

TGCTCAATCA

AAAAAAGATG

GGAGAATTTA

CAATTATCCA

GAACCAATCA

TCTTCATAY[

CTAAGTGGCA

AAGTGAATAC

TACTAAGGAA

ACTGTGAATC

AACCACACAT

CCAAGATGCT

GTGCAGCAAA

AATGAATTCT

TTCGAGAAAA

GAGCTCCAGC

CTGCTCAGTA

AAAAGTTTCT

AGAAAGACAC

TTACATGCAA

GAGGAAGTAT

TCAAGTGGTG

TGTGGCATTT

TTATGGATGC

GAACCAAGAT

TAGCACAGTT

TCATI'GCCAT

AAGACTTGAT

TTATTTTATA

GTAGGATTAT

GGTCCTACTA

CTTAAATTGC

ACTTGGTCAT

CTGCTTCAGG

TGAGCCCATG

AGGGTGTTTT

AGTCATTACT

AGCATGAAAT

AAGATTTATT

ATATGGCAGC

CACATTGAGC

AGTAACTAAG

TCAAACTCAC

AATACAATGT

TAT-TTAAATG

TCAACCTCTA

ACAACAGATT

GTCTAGAGTC

CCACTTGTTT

ATTGTACACC

ACGTTTGTGG

CAGAGACATT

CATTCATTCT

CTFITATATA

TJ7AACTTCAA

ATTCTCTAGT

AATAACCAAA

CCTTTATCTG AT"TAACAGAG TCTAAGTCAC AT-rCTACCTT AGTAAGGCAA AGYI'ATCAITr AAGGAGCCAT ATAAATGGAA AATGTCCACT TTTGCCACAC TTAAAG1TTTC CAAGAACAAA AAGGAAAATT AGACTTGACT CAGCAGAACT GTACTGTGTC TCTAGGTGAT ACCTGCTCCA CTCCCAACTT GATAACTGTA CCCTAAACCA GGGGGAAGAA GAAAGAGAAA AAGGAAATCT GCAAAGAAGG AAATGTGAGC AGATAGTGCA GTCCTCGTTI

CTATTCCATT

ATGCTGTGGA

ACAGCTTTGA

CCAGCTCCGG

TAAAAAATAC

TTlCAATATTF[

TCTGAATATT

TGAAAAGACA

AAATTAAGTT

CCCAACCTGA

TGAACTAAAT

GGGAAAATAA

TGGGTCTGAG

TTGATTCTTA

CCTGCACATT

TATCAGGAAA

TAATGATCAT

AATATATGAT

TCCTAGGGTC

TCCTCACCCT CAGCCAGGCA GGTGGAGCAA GCTGTCY[rAC TAGCCCCAGA CTACCTGCCT TTTGT-rTAAG CCTCTGAT'rr TTTGGTCTAA ATJTCTCTITCT G'rrCTGTTAA TGGTGAAATG AGGATTCCAG TrAAATTCAA ATTTAGATAA GGACATACTT AACTAAAAAA TGATTTGIrG CTCTGGCAAC CCCCGAGAGA GTGAAGAAAG YJ7ACGGATGT GTTTAAATGT CTTATrCTAG AAAAGCAGAC ACAGAGACCT GGCCAATATA GACCAAGGGC ATAGTGAGAT GATTTGGGAA GCCTTATAAA TCTCCAAGAG AAATGACAGT AAGCTATGTG CTTGAAACCC ACTrCTGATA TATCAATTCT ACAATTGTAA AGTGACAGTA ATGCAACAGT AGGAAACCCC AGCCTCTCTG AA1TATITCC ACAAACACTG ACCCCTCTAC GCTCCCTCAT GTTACTCCCT TCTAAGTCAA kTGACCTAAA TGCAAGAGAA CTGGGAATGG GGGAATTCCT CTAATACAGG AAGGGTGTTC ACAATCCATC ACTUGGTTGC CCCACATCAA AATTATCCCA CTGAACATAA TCTT-rACTAT GAAATAACCC AGCTCTAACA GTrFACTGCTT ACAATAGT1T GGTCACATF TCAATTTGAT TAAAGTTCAC TACCAACATG CTATATATAA CT-rAAAATAC ACAGGTATAC ATATGACAAA CTGAAATTGG TCCCCTGACT GGGGCTATAC AAACTTAAGT CU-GGTGGAT CTGAATCTTG CTCAATTTCT AATTATATCA GTGAAAGCAA 2TGATGTAAG ACCACAAGGA CAAGAGTTCT 2CCGAGAGAA GAGTTGCCAA CTTTGGCAAA ACAACAATTT TT7AGTATTA GTGTGTCCCA TTCATCTGAA ATACAAATTT AACTGGGCAT TGGTACAAGG ACACTTAAGA AGACCAGATT AsGAGAGTTAG AGCTGTAGGT AGAACTTGGG TACTAAGGAG TGGATCACTC TGGTCACAAG AGGCACTTAT ACACTACTCA TCCCCGTCT-7 CCACCATGTG GACTGCTTTC TGTAAGTCCA TTATAAGGTG TGTGATCTTT GTCATGTTAA ATGGTGTGTC CCCAGGTTGT TGTGGAAAGC GAGCAAACAC CC'ITCTACAT CITTACUCC

GGCAGGACTC

ATCTATTTCT

AATGGTAATA

ACGCCTAGAC

TGTTCTTTTC

TATrCCTCTA

GAACCATAAG

CATATTGATA

TCTCAGAAAA

CCACATCTAC

TFCTCTCTA GTGCTAGAGC AGAAAGGGAC CTTGATrTGA AGGAGGAGAG AGATCCAGGT CAATGTTT AAGTTTTGAC GTGTAGTGGA ATTGGAGTGG GGTTAAGATA AAGATGTr CCTGAAACCT CACTGGGACT CTGCAATATG CATTTCTGAC GTGGGCCTTYF CACAAGCTGC CCTAA'rrGGG AGAAAAGTCA CCATAGTTGA GGGTACATCT

CTATGATAGC

GGGTTGCCGT

TGCTAATTCC

CCTCCTTGGA

CAAATTACAA

AGTGGAGTGG

TTAATTTGTG

TATGGAACAT

AAAGAAAAAC

GAGAAGICCAG

TGATTTAAAA

GAAAGTAATA

AATCCCAATT

TCTCTCTTCT

GGAATTATCA

AATGGAAACT

CTTACATACT

AGCCATAAAA

ATGGTCCCTC

CACTTrGGGAG

AATTGACTAT

ATATATCTAA

GCTCTTrTGCA

GTC'TTTCA

TTTAAATGGG

AACAGGAAGA

CACACATACA

GTC1TrTGCAC

CATTTCCTGC

TTCAGGGCTC

CATGACATGA

GAGTTGTGAC

TAAAGTTCTG

TGTGGTUCAG

GAAGAAGCTC

CACTGCACAT

TATGTGCATG

TGAACGTTCA

CCCCAACTCC

AAGTTCCTT

CTAGAAAAAC ACTGGGTGAT TCTAGGGGAA CTTCCGATCA GAAACAGCCA ATTCAGAGTG AGAGAAGAAA ACGTGACCAT GCAGTTCCTG TGGTTACCAG CCTTGCCCCT cTCT-rGCCTr CTGGGAGT-rA TAAAACCCAA GACTGGAAAG GAAAACCAGC ATTTGCTCAG GCAGCCTCTC TGGOAAGATG CTGC1TCT-rC CTCTCCCCCT GCTGCTCT1T CTCTTGTGCT CCAGAGCTGA AGCTGGTGAG TATCAGGGTT CTTCCCTCTG AAATCTGCAG TATCAGCTCC TGAAACAAAG ATGTTTAGTC TGAAATAGCT GACTCCTAAA CAGGGTTCCA AGATCTCTCT TCAAGAGTCC CACAGAGGAA A1TCCACTT GGGATGTGTG CCACCCCACC CCCACCCCCA CCCACTGCCA TrCTCTACAG CCTAGGACAC CCCCAGGAAC AAGGAATTTC ACCTCAAUTG TAGAAAAGCC CAGAGCAAGT GGAAGGAAAA GGGGTATCCC CAGGAAAACA GACATGTCCT C'TAATC1TC TGAGCATCAG GGCTACCCAT TACTTTGTGA C1TCTCACT CTGTGACCAT GCTCAAGAGC TATGGAGAAA TCTAAAACAG GAACCTGGAC AGTGGGTCCT ACACAGAGAC AGAGGAGAGT GGGCCAGGGC AAGGTGGGAG TGGGAGAAGT CTGAGATGAA AACATCAGAA TGGAGCAGAG GCAAGAATGA GATCACCT GGGAGGUTAT GGGTGGGGAA AGATACGAAA TACAGGAGAC AGGAGAGGGA AGATGGGCGG AACACAGGGT GAGAATGAGA TTCCAGGGAA GCCTAGCTCA

GCTTTAACCC

TCCAGGGGAG

GTAACTTCCA

CTCAT[rGTGC

ATCCAGGAAT

GACTTTGGGC

CTTCGGAGGA

TCAAGACACA

AACACTGGCT

CCCCCACTTT

AGGAAGTGTG

AAATTGTGTC

CATGAAAAGG

TCACCTCAGA

TAACAGTCAC

GCAATTCCGT

CCTCTCT7CT

CTTAGGACTT

CATTTCGAGG

GGGACACTCC

GAAGAACAGG

GGCCTGCAGC

TCTGCATTTA

TAGAAGGAGA

CGTGGTCCAA

ATGTGGATGA

CCTGGGTCTG

CTCACC17CT

CCAGGGCATC

CGGCCCTGGA

AACTGGACCT

TAAGCCTCCA

AATTTGTCCA TTCATTGGAG AGAGTATCTA ATCATCGGGG GCACAGAATG CAAGCCACAT ACGGTCCCTC AAAATTTrGT GGTGGTT-rCC AGGAAGGTGA GACAACAGGG TCTAUTTATC ACACCTGCAC TGGGGACTGA AGAGGGGGTC TGAAAGACTT TAGTCTGTGT F[GAATAGYF AAAGGAGGTC CTGTCCGAAG GTCCCTCTTG CGGCTCACTT TTCAGGGCCC CACCCAGTCT CTAGTTCTCA GGGTCCTGAA CCCATCATTT CCCGTTTTAA CTGATATCTC CTGCTTCAGG AACCCTGTCC CCTGAGTCCT CCCTGGCCTG TGTTTCCTGA GAAAGCTCT-F TCATGAGTTA GAGATGGGTA GAGTCCGGCN ACCCAGTGAC AGAAACCCCA AGCCATCACT GTCGCCTCCT TGGCCGTGTT CAAACCCTGG GGTGCTCTGT TCCCGCCCCT ACATGGCCTA CCTGGAAATT TFATAAGACG GAACT1TrGTG CTGACGGCTG TCCAAATGGG AGATGAACAA CCAGAGTAGC CTGGGTCTTG TCAACTTTCA GGAGAGGGAA CCTTGAGCCT CAGTCACTGA GCTAAGCTCC TTfGCAGTAGC ACCCCTCACC CCTACCCAAC CAGGGCCACT TCCTCTATGG CCT7TTCAAG TATGGGAGCA GAGAACAGGT CTACATAAGA GGCTGGCCCT CATGCAGGGT TCCCTGAATT TTCAGTCCCC AGCAATTCCA GGGGTCGTAG AGCCTGAGCC CTCAAATGCC ACAAGTGGCC AGAGTTTAGT CCTCTTTTCT CAGAATGAGC MTCCTTCCT TCTTCCTCAC AGCAGGTCTA AGACACATGG CAGAAGCTTG AGGTTATAAA CACGATATCA TGTTACTAAA GGTGACAACA TCCTTCAGGT CCTCATTGCC CTGAATT'17T CTCCCTGATC ACCTCCAACT GTCCAGAGCC AAGGAGAAAG CCAGCCTGAC CCTGGCTGTG CTGGGAGAAT GTGCCGGGTG GCTGGCTGGG AGAGGTGAAG CTGAGACTCA TGGATCCCCA CTGTGTGTGG GCAATCCCAG GAAGACAAAA AAACTCACTG TTCAGGGACC TGAATGCTCT CCTTGGAGCC CATAACATAA CATCCAAAAT ATAACACU-C CCC'TrCCAC T1TCCCATTCT GGCTATAACA TGAAGCTACT ACTGACAGTC CTTCATTCCC CCITCCCATC ACAATTCAAC TGTGTTGAAG CCGGGCTCAG

CAGAGGAAGA

TACTCTTCAC

CCTAAGCTTC

CACCCTGTCC

TTCACAGTTG

TTTGTCCCAC

ACACTCTGCA

CAATCTTCAG

TTCCTCTCCA

CACUTCAGAG AC'ITTGACCA AGGTGATCCT CCAACTAGGT TGGGGTCAGC AGGTTGTCAG GACAGCCTCT GACCATCCAT CGGTCCCAAG AAAGGAAGAA TCAGGTGACA GGGTGAGCAT CACAGGAATT TCCAGTCTAC TGCACTGGGG GCATGGGGTG GGGGCATCAG AACTAGATGT ATAAGTGAGG

GCTGTCCTCC

ACTGTGGAGA

AGCTCCACCT

ACTTTAGGTC TCACTGTGAC TCCAAGCTGG CTGGCAGACA TCTCTCTCTC CTCCCCCTAC AGGGAGACTC TGGGGGCCCT GTATCCTATG GACGGTCGGA TGCAAAGCCC CCTGCTGTCT TCAACCAGAT CCTGCAGGCA AATTAATCCT GGATCCTGAG TAGCAGCAAA GTGTGTGCAA CTCATTCTGG TTCTACCCTT AGAGGTCTCC TACAGGTAAC AGAACTTTCA ATAAACTTCA GGAGTGGAGG AC'rrCCCGGG CTI'CTGTGTG CTGGGGTGGC TCACCCGAAT CTCCCATTAC CCAGCCTGAA GGGAAGCTGG GGTTCCCTCA GCCACAACCC GTGAAGACAC AGCTTCTAGT CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC TrCTCCTGCA CATGTGACCT GATITCCCAGC CCAAGCACCA AGGA CACCGCTCCT GTCAGCCAAC AAATATCCAT TGAGCGACAC CTGTGTC.CCA GAGAAGTGCA TCAGTGGGCT TGGTAGTAGA GGGTAGGGAT GGAGTGAAGG CAGGCTGGTA GGAGGTGGGG TGGGGGGT7T CAGTCTCAAA ACTCCCATGA AACTCCACCC AAGAGGCTGG GTTTCTAGGG CCCAGAGCTG CCCTCCCCCA GTCCCTrCCC AGCTACGTCC AGAGAAGAGC TGGAGGAAGT GAGAGGTCGG AGGGGAGCAG AGGATCCTCC CGTGCAGGCT GTGGATGTCA CTCACTTCCC AGAGATGCAT CTGCTCCCAG CCCTGGCAGG GGTCCTGGCC ACACTCGTCC ACTGACCCAG GTAATAGTCC CCTAGACAGG CAAGGAGGAG GGAGGGGAAA TCTTGGAGGG GGTCTTGTGG cT-rGCTGAAC CCTGAGTCCC CATCTCTTrG TGGAGACCTC GGTCCTGCGA GACTOCATAG CAGAGGCCAA GTTGCTGGTG GGTGCTGCTC TGGGCCCTGG GTAGGCAGGA AGAATGTCCC AAACCAGAGA GAAGTTTCAG CCCTAGAATG GGCTATAAAA CTGGGGGTCC TCAAAGTGAG AGCTGGTGAA GCCTCGCTGC TCGCCCAGCC CTGTGAGGGC TGGAAGGGGA AGCACTTGGG AACAGCCTCC CCTGGGGCAG GATGCTGCCT ACAATTGGAC CCAGAAGAGG TGGACTTGGG TCTGGGGGCT GCATGGGCCT GGGAGGATCA GT TAATACCTrG TGGGGTCAGG GAGCCCATGT CCCGTGCTGA TGTTATTTCC CCACCAGGTC CGGGCTGTCT CCAACCAGAT TGTGCGCTTC CCCAATGAGA GACTGACCTC CGACCGTGGC CGAGCCCTCA TGTTCATGCA GTGGGGCCAG TTCATTGACC ATGACCTGGA CTTCTCCCCG GAGTCCCCGG CCAGAGTGGC CTrCACTGCA GGCGTTGACT GTGAGAGGAC CTGCGCCCAG CTGCCCCCCT GCTYTrCCCAT CAAGGTACCT ACCCTCAGCC AATCTCCCAT GCCCTrGTGT GGCCTCCCCC AAAGGCAAGG TGCTGGGGGT GGGGATCTGG AAGACTGGAG CACCATCCTT AAGGAGCTGC CTGTGGAGCT AGGGTATGAG ACAGAGACAC AAG CACTGTCTCC TCTTCCATCT CAGATCCCAC CCAATGACCC CCGCATCAAG AACCAGCGTG ACTGCATCCC T-rTCTTCCGC TCGGCACCCT CATGCCCCCA AAACAAGAAC AGAGTCCGCA ACCAGATCAA CGCGCTCACC TCCTrTGTGG ACGCCAGCAT GGTGTATGGC AGTGAGGTCT CCCTCTCGCT GCGGCTCCGC AACCGGACCA ACTACCTGGG GCTGCTGGCC ATCAACCAGC GC'ITCAAGA CAACGGCCGG GCCCTGCTGC CCTI7CGACAA CCTGCACGAT GACCCCTGTC TCCTCACCAA CCGCTCGGCG CGCATCCCCT GCT-rCCTGGC AGGTCAGACA GGGAGGAAGG TGGTGTCrrC CCAGGAAACA GCCATCCCTG GGGTCCCAAC TGGGAAGCAA TGGTGGGATG TGGTGAAGGT ACATGG1TG GGACCTCAGT ATTAGGCACA CCATAAGCAT GGATCTGTGC AC TGAAGAGATG GAGGTCCAGT GAGGGCCAGG AGTTTGGCCC ACCCCGTCTC TCCCATCCCC AGCCCTGGGT CTACCCTGGT AGAAAGACAT T-rCTCTGGGA AAGGCTGCAG TAAATCTGAG CYI7GGGGTTT TCAAGGTGAC ACCCGATCAA CGGAAACCCC CAAACTGGCA GCCATGCACA CCCTCTTAT GCGAGAGCAC AACCGGCTGG CCACCGAGCT GAGACGCCTG AATCCCCGGT GGAATGGAGA CAAACTGTAC AATGAGGCTC GGAAGATCAT GGGGGCCATG GTCCAGGTAA GGAGCTCTGC ATCCCAGCAT CCCCC C'FITGTATCT CCACCCACCA ATAGTAAATT AATGTTGTCA CATT-rGACGT GATGACAATA AAGAATATGT CTGAGCCACC CTGAAAAG GCAAGGGTAT GGGTGAGTAG CCTCTGGGGA ATGTTCCTCC TGTCTrCCCT TCCAGATCAT CACCTACCGA GACTIMCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT GGCCACACAA TGCTCCAGCC CTTCATGTTC GGCTTGGACA GTCAGTACCG ATGTCCCACT TAGCTCTGCC TTC'TrGCCA GCTGGCGGAT CGTGTATGAA GGCAAATGGG GGTGAGGGTG GGGAGCATGC CCTCCCCTAG GTGG TCACCCTGGC CTTCCGCTTTr GGCCTCCGCA CCCAACTCGC GGTGACCAGG TTTTCCAGGG TCCAGCTGCT TCATGTCTCT CCAGAACTCT GTTTCCTGAC AAACGTTFACT AACATACCCG ACTGGCTTGT CCAGCTCTGG GCTAGCTTGG CATCATGTGA TAACCCAAGT AGCTTCCCAG AGGCTGGTCC AATCTGTGCT GCTCACATTC CCTGCCACCA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCU-CC AGGTGAGGGG GCTGTCCACC TCTFCTCCCA GCTTTGCTCG GGCCAGGCTG CTCAAGGGGT TCTGGGAAGA CCCTGGTACC CGACTGCCTG GTAGGTTCTG GTGGCAGAAA CGAGGTG'ITT TCACCAAAAG ACAGCGCAAG GCCCTGAGCA GAATTTCC'rr GTCTCGAATT ATATGTGACA ATACCGGTAT CACCACGGTI7 TCAAGGGACA TCTTCAGAGC CAACATCTAC CCTCGGGGCT TTGTGAACTG CAGCCGTATC CCCAGGTTGA ACCTATCAGC CTGGCGAGGG ACATGAGGCT TCTGCAGGTA AGGGGAGGCC ACCTCCAGCA CCCTGGGCTG GTTrAAGCCTC ACATCCT7CC CTGGATGGAT GGCTGAGTCC TCT-rAGGTCT CTAAGCAGAG AAAACAGAAC T-FGTCACTAG GTACTCTFC CAAGTGGCTT CCCAATGTGC TAGTTTrCTGG GCTGACAGTC AATFTCCAGGC CCTAGGACTT TGGGGGGAAA TTAGGAGCAT CCAACTA GAATTCCGTG GCCAGGACCC CTGCCAGGGC ACTGACCCAG CCTCCCCTGG GGCAGTGGAG ACCTCGGTCC TGCGAGACTG CATAGCAGAG GCCAAGTTGC TGGTGGATGC TGCCTACAAT TGGACCCAGA AGAGCATCAA GCAGCGGCTT CGCAGCGGTT CAGCCAGCCC CATGGACCTC CTGTCCTACT TCAAACAACC GGTAGCAGCC ACCAGGACAG TTGTTCGGGC CGCAGATTAT ATGCATGTGG CTYITGGGGCT GCTTGAAGAG AAGTTACAAC CCCAGCGGTC CGGACCCTTFC ATTGTCACTG ATGTGCTAAC AGAACCACAG CTGCGGCTGC TGTCCCAGGC CAGTGGCTGT GCTCTCCGGG ACCAGGCCGA GCGCTGCAGC GACAAGTACC GCACCATCAC TGGACGGTGC AACAACAAGA GGAGACCCTT GCTAGGGGCC TCCAACCAGG CTCTGGCTCG CTGGCTGCCC GCCGAGTATG AGGATGGGCT GTCGCTCCCC T-rCGGCTGGA CCCCCAGCAG GAGGCGCAAT GGCTTCCTTC TCCCTCTTGT CCGOGCTGTC TCCAACCAGA TTGTGCGCTT CCCCAATGAG AGACTGACCT CCGACCGTGG CCGAGCCCTC ATGTTCATGC AGTGGGGCCA GTTCATTGAC CATGACCTGG ACTTCTCCCC GGAGTCCCCG GCCAGAGTGG CCTTCACTGC AGGCGYIGAC TGTGAGAGGA CCTGCGCCCA GCTGCCCCCC TGCTTTCCCA TCAAGATCCC ACCCAATGAC CCCCGCATCA AGAACCAGCG TGACTGCATC CC'FrTCTTCC GCTCGGCACC CTCATGCCCC CAAAACAAGA ACAGAGTCCG CAACCAGATC AACGCGCTCA CCTCC1TTGT GGACGCCAGC ATGGTGTATG GCAGTGAGGT CTCCCTCTCG CTGCGGCTCC GCAACCGGAC CAACTACCTG GGGCTGCTGG CCATCAACCA GCGCT-rTCAA GACAACGGCC GGGCCCTGCT GCCCTTCGAC AACCTGCACG ATGACCCCTG TCTCCTCACC AACCGCTCGG CGCGCATCCC CTGCTTCCTG GCAGGTGACA CCCGATCAAC GGAAACCCCC AAACTGGCAG CCATGCACAC CCTCITATG CGAGAGCACA ACCGGCTGGC CACCGAGCTG AGACGCCTGA ATCCCCGGTG GAATGGAGAC AAACTGTACA ATGAGGCTCG GAAGATCATG GGGGCCATGG TCCAGATCAT CACCTACCGA GACTfrTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCTTT GGCCACACAA TGCTCCAGCC C'TCATGTTC CGCTJ7GGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC 'ITCTTTGCCA GCTGGCGGAT CGTGTATGAA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGGTACAAT GCTTGGAGGC GCTTCTGTGG GCTCTCCCAG CCCCGGAA'F[ TGGCACAGCT TAGCCGGGTG CTGAAAAACC AGGACTTGGC AAGGAAGTTC CTGAAT'ITGT ATGGAACACC TGACAACAT[ GACATCTGGA TTGGGGCCAT CGCTGAGCCT C1TTGCCGG GGGCTCGAGT GGGGCCTCY[ CTGGCUTGTC TGTTCGAGAA CCAGYJ7CAGA AGAGCCGAGA CGGAGACAGG TTCTGGTGGC AGAACGAGGT GTITCACCA AAGACAGCGC AAGGCCCTGA GCAGAATTrC CTTGTCTCGA ATTATATGTG ACAATACCGG TATCACCACG GFTcAAGGG ACATCTTCAG AGCCAACATC TACCCTCGGG GCTTTrGTGAA CTGCAGCCGT ATCCCCAGGT TGAACCTATC AGCCTGGCGA GGGACATGAG GCTTCTGCAG GAGTCTATCC CAAGTCTCCA ACMTTGGAG ACAAGGGGAA GGGGAGGACC ATGAGGCTGC CTITGTCTCCC TGGAGCAAGT GCAGGCTCGT GACGCTTCTG CTGGCTACAG CTCAGAGCTG GGTTCCCCAG CCAGGAGTGA AGGCTGGGGG CTCCTATCAG CAATGGACCT TCCGCCTTGG GAGCCTCTTA GGTATrAGGC TATGAATCAG CGCCACGTGC AAAGGCTTGG GAGCCAAGCC ATGTGGTCTT GCACCCCAGG CAAGAAAAGT CAGCTGGAGG GTACAGCA CTTrCTACTG TFCCCAGCC CTCCCTCCCC TCCCTCACCA TGACTAAGAG ACCACTCGGT CCTAGCCTCC AGACACCCCA CAATACTCCT CTGAGCCTGA GGCCAGGCAG CATGCTCTGC TITCTACCAAT AAAGCACTGC CGGAATTC CATATGTATG GGAATACTGT ATTTCAGGCA 'FfATAAGGAA TGAAATTATA GOCCGOCAT TGTGGCTAAC CC31TGTAATC CTAGCACTTT GAGAGGCTGA AGTGGGCAGA TCACTTrGAGC TTCAGAGTTC GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA AAATATTAGC TGGGTGTGGT GOTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG CTTGAGCCTG GGAGGCAGAA GTTGCAATGA GCAGAGATCG TGCCACTCCG CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA TAAATGAAAT GAAATTATAA GAAATTACCA CTITTCATG TAAGAAGTGA TCATFI7CCAT TATAAGGGAA GGAATTTAAT CCTACCTGCC ATTCCACCAA AGCTTACCTA GTGCTAAAGG ATGAGGTGUT AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CTrCC'FrCCT TI7CCCT-rCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAATAA TGGCATCATC TAATATCACT GGCCTTCTGG AACCTGGGCA TTCCAGTG TGTTCCATAC TGTCAATATrT CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATTAA CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC TGCCACC'rrG GACTrfGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA ACTGTACACA AGCTGGGGAC ACTCCC1TTG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CCYI1TATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC ATAACTTTGT AGCGAGTCGA AAACTGAGGG TCCGGCCGCA GAGAACTCAG CCTCATTCCT CTCTCGGCCA CCT-ITGATGA GGGGACTGGG CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG TTCCTGGTTT GACTGTCCTT ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C

CAGTGTGTTC

GCTTTAAAAT

CACAGGTCTC

CATATGTATG

GGAATACTGT ATTTCAGGCA TTATAAGGAA CTAGCACTTT GAGAGGCTGA AGTGGGCAGA GGTGAAACCC AGTCTCTACC AAAAACACAA GCTACTCAGG AGGCTGAGGT GGGAGGATCG TGCCACTCCG CTCCAGTCTT GGTGACAGAA TAAATGAAAT GAAATTATAA GAAATTACCA GGAATTTAAT CCTACCTGCC AUTCCACCAA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CAGAGGCCTG TCTGGAATAA TGGCATCATC TGTrCCATAC TGTCAATATT CCCCCAGCTr CAGGGATTAA CCAGAGAGCT CCCTGCTGAG TGGCCAAATA AAACCTGGCT CCGTGGTGCC GACiTFGGAC CAGAAAGAGG TGGGTTGGGT TCACCCACAG GCCCTGGCAG TCACAGTCAT TGAAATTATA GGCCGGGCAT TGTGGCTAAC CCYTGTAATC TCACTTGAGC TTCAGAGTTC GAGACCAGGA TGGACAACAT AAATATITAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA CYJ7GAGCCTG GGAGGCAGAA GTTGCAATGA GCAGAGATCG TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA CTrTTTCATG TAAGAAGTGA TCATTTCCAT TATAAGGGAA AGCTfrACCTA GTGCTAAAGG ATGAGGTGTT AGTAAGACCA CTTCC'FrCCT TTCCCTTrCCA AAAACCTCAA GTGACTAGTT TAATATCACT GGCCTTCTGG AACCTGGGCA T1TTCCAGTG CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TCTGTCTTAG CAGCCACCCT GCTGATGAAC TGCCACCT-rG GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG AAATTAGCTA ACTGTACACA AGCTGGGGAC ACTCCCT-rTG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CC'FfTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC GAGAACTCAG CCTCATTCCT CAGTCCCGAA GTTCTCAAGG CCAGCTGCAA GGTGAGTTGC GACAGTCCCG AAGTTCTCAA AGCCAGCTGC AAGCCCCACA YITGTAAAGCC ATAGAGATGG AATGGGGAAA AAGACATCAA ATGACCTTCA GTATCACAAC GAAGTCTCCA GAATCTCTGG AACTGGGGCA GCGGGATGAC CCAAATCTTG CCTGGGGTCC TCCAGATGAG CTTCTACCTC ATAGAGGAAC ATCTGGCCAG CGGGAGATGA GCTCATCTTC GTGGTCCAAC CTGCAGGTCT AGACACGTGC G~rACTCCAC ATGGCAAGCA CGACTITCCGG CAGCATCAGA GGGGACCCTG TACGGCCGCT TCGATGTGGT CACCTGACCT TGTGCTTGAG GTGGTACGCC CTGCCTGCAG TrCAATGGCT GGTACATGGG TGGAGGAAGT GGGCAGGAGA CGTTGAGATC AACATTGCTG GCTGCAGAAT CCTTrCATGAA TT~TGGCTGGT CCCTCCCATG CAGTGTGTTC ATAACTTTGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GCTTTAAAAT CTCTCGGCCA CCTTJ7GATGA GGGGACTGGG CAG~rCTAGA CACAGGTCTC TTCCTGGTT[ GACTGTCCTT ACCCCGGGGA GGCAGTGCAG CCTGCTTTAAA ATCTCTCGGC CACCTTTGAT GAGGGGACTG GGCAGTTCTA

GGCACAGGTC

GTGAAGAACA

CCTGTCCTTG

CAACAATGTG

CTCAGCAAGC

TCAAGCTGGA

YITTCCAAGAC

ATJTATGACTC

AAGCTATCGA

GGTGGAAGCG

GCCACCAAGC

TCGATGCCCG

CAACAATGGC

GTGTGGAATG

CCAACGTGGA

CCCCCTGGTC

GTGGCCATGG

TGGCCAACAT

CACAGAGATC

ATGGGCCTGG

TGATCCATAG

GTACATGCAG

TCTGGGAGCA

TCTTCCTGGT TTGACTGTCC TTrACCCCGGG GAGGCAGTGC TCTGAGCTCA AATCCAGATA AGTGACATAA GTGACCTGCT GAAATYITCTG TTCAAGACCA AATTCCACCA GTATGCAATG GAGAAAGCCC CCTGTGCCAC CTCCAGTCCA GTGACACAGG AGCAGAATGA GTCCCCGCAG CCCCTCGTGG AGACGGGAAA TGCAACCCCA TlGTCCTCCC CACGGCATGT GAGGATCAAA ACACTTCACC ATAAGGCCAA AGGGATTTTA ACTTGCAGGT CCAAAAGTTT GACCAGAGGA CCCAGGGACA AGCCTACCCC ATTGTCAAC CAATATTACG GCTCCYI7CAA AGAGGCAAAA GTAACAAAGG AGATAGAAAC AACAGGAACC TACCAACTGA AGGCCTGGCG CAATGCCCCA CGCTGCATTG GGAGGATCCA CAGCTGTTCC ACTGCCCGGG AAATGTTTGA ACACATCTGC AACATCAGGT CGGCCATCAC CGTGTTCCCC CAGCGGAGTG CTCAGCTCAT CCGCTATGCT GGCTACCAGA TGCCAGATGG ATI7CACTCAG CTGTGCATCG ACCTGGGCTG GAAGCCCAAG CTGCAGGCCA ATGGCCGTGA CCCTGAGCTC TTCGAAATCC AACATCCCAA ATACGAGTGG TITCGGGAAC TGGAGCTAAA GCTGCT-rGAG GTGGGCGGCC TGGAGTTCCC AGGGTGCCCC GGAGTCCGGG ACYITCTGTGA CGTCCAGCGC TACAACATCC AAACGCACAA GCTGGCGTCG CTCTGGAAAG ACCAGGCTGT TTYITCAGAAG CAGAATGTGA CCATCATGGA CCACCACTCG AATGAATACC GGTCCCGTGG GGGCTGCCCG GCAGACTGGA TCACCCCCGT GTTTCACCAG GAGATGCTGA ACTACGTCCT CTGGAAAACC CATGTCTGGC AGGACGAGAA GCGGAGACCC GTCAAAGCTG TGCTCTT-TGC CTGTATGCTG ATGCGCAAGA TCY[TGCGAC AGAGACAGGA AAATCAGAGG CGCTGGCCTG CAACCCCAAG GYTGTCTGCA TGGATAAGTA CAGGCTGAGC GTGACCAGTA CG111GGCAA TGGAGACTGC CCTGGCAATG TGAAAGAGCT CAACAACAAA UTCAGGTACG CTGTGTTTGG CGCCTTTGCT CATGACAYITG ATCAGAAGCT GTCCCACCTG GGGGATGAGC TCAGTGGGCA GGAGGACGCC 'TrCCGCAGCT AGACGTTJ7GA TGTCCGAGGC AAACAGCACA TTCAGATCCC CCCGCACCAC TACAGGCTCG TGCAGGACTC ACAGCCT-rTG GCCAAGAACG TGTTCACCAT GAGGCTCAAA TCTCGGCAGA CCATCCTGGT GGAACTCTCC TGTGAGGATG GCCAAGGCCT TITGCCCAGGC AACCAGCCGG CCCTGGTCCA AGGCATCCTG CAGACAGTGC GCCTGGAGGA CCTGGATGAG AGTGGCAGCT GCTCACTCAG CCAGGCCCTC ACCTACTCCC CGGACATCAC GCTGGCCCAG GTGGCCACAG AAGAGCCTGA GAGACAGAGG AGCAAGTGGA AGTTCACCAA CAGCCCCACA TTCCTGGAGG CTGCTGGC17 CCTGCT1TCC CAGCTCCCCA TTCTGAAGCC TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA GGAATGCCAG CGCCTTCCAC CTCCCCGAGG ATCCCTCCCA GTCCCC1TC TACTACTATC AGGTAGAGGC AAGAGAAGAG AGATTCCATTr GAAAGTCTrG CAATGGCGTC CCGAGTCAGA GTCACCATCC GGACCTGGGG GCCTTA'rrCA GCTGTGccTYr TGCCTGGAGG AGGAACGGCT GCTGTTGGTG GAGAGAAACT GAAGAAATCG CTCTTCATGC CCTCGGCTCC AGCATGTACC CTCGGTTCTG GGGGCCTCTC AGCTCACCCC GATGGGAGAA GGGCCGTGCA AACCTTCAAG GCAGCCTGTG CAAGCTCTAC ACCTCCAATG TGACCTGGGA GACCTCAGCA AAGCCCTCAG CAGCATGCAT ATCTACAAAG TCCGACATCC AGCCGTGCCA GAACTACCTG CCGGGGGAGC ACCTTGGGGT GAGCGAGTGG TGGATGGCCC CACACCCCAC ACTGGGTCAG TGACAAGAGG CTGCCCCCCT CACACCCCCA ACCCAGCTGC TGCTCCAAAA CTGGAGGCCC TGTGCCAGCC CTCAGAGTAC TGCTAGAGGA GT-rCCCGTCC CTGCGGGTGT CAGGT-rcTAC TCCATCAGCT CCTCCCGGGA ACCTACCACA CCGGAGATGG CCAGGGTCCC AGCCCCAAGA CCCAGTGCCC TGC'TTTGTGC TCCTTGCATC CTCATCGGGC CTGGCACAGG CATCGTGCCC GACTCCCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT ACCACATCTA CCAGGAGGAG ATGCTGGAGA TGGCCCAGAA TI'CCCGCCTG CCTGGCAAGC CCAAGGTCTA TGTTCAGGAC CTCCGTGTGC TCCACAAGGA GCCAGGCCAC CTCTATGT-T CCCACACCCT GAAGCAGCTG GTGGCTGCCA AGCTGAAATT TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATCTTFC GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GAGATGTCAG CTGCCGGCAC AGAACTTAAG GATGGAGCCA GCTCTGCAT[ GGAAAGTGAT ATCCCCCAGC CTCAAGTCTT ATTTCCTCAA CTCCTAACAA GTAGCACCCT GGATTGATCG GAGCCTCCTC AGACAAAATC TTAAATGCCA GGCCTGGCGA GTGGGTGAAA AAGTGACCAC CAGGAGGTGC TATCGCACCA CTGTGTATf TGTATTTAAA AAACTAACAC CCAGTCTGTTr CCCCATGGCC GGAGATATTT ACATGAATTG CATTTTACTT TAATC ACGGACGCAC AGTAACATGG GCAACTTGAA GAGCGTGGCC TTCCGGAGTT TCTGGCAGCA ACGGCTCCAT TGGTGTTTGG GTGCCGCCGC CCAGATGAGG

GGGGGTGCTG

ATCCTGCGGC

GCGGGGATGT

GAATGAGGAG

GGTGCTGTAT

CGCTCTGAGG

ATCTGAGGTC

CGTTGCTCCC

TCTCAAACTG

GATGGAACTT

AACTGCCTTG

ACTTGGGTCT

GAATTCCCAC

CAGGAGCCTG

CCACCCCGGC

GAGCTCCCCG

ATCACCTATG

CATGCGGTGC ACACAGCCTA AGCAGCTGGC CAGCGAGGTG GCGCATGGCC CGGGACGTGG CAGGTCGAGG ACTATTTCTT TTCCTfACGA GGCGAAGAAG GCCTACAGGA GGGGTTAAAG ACAGGGCCTG GGGAGATOGA CATCAAGCCC TTACTTGAC GGGCCTCCCT GGTCCCTTGG GCTGCTGAGT GCAGCACTTC TGTACAGYITA TITATGCCTC TCCCTGTATG ATTCCTTGAT TCTGCTGCCT GCTCCAGCAG GGCCACCCTG CGGCCTGGGG CCCTGAGCCC AGCCGGGCCC CTAACCCAGC CCCCAGAGGG ACACCCTCAG CGCCCAGGCG CTGGGGCTGG GCCTTGGGCT GTGCGGCAAG CAGCATCCCT ACTCCCACCA GCGCCAGAAC GCCCAAGTTC CCTCGTGTGA AGAACTGGGA

CAGGGCCCAG

ACAGCCCCCC

GGTGGGGAGC

CAGCAGGATG GGCCCTGCAC CCCAAGACGC TGCCTGGGCT CCCTGGTATfl TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC AGCTGCTGAG TCAGGCCCGG GACT[- CATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC CCACGAACAG CGGCTTCAAG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT TAGGGAGAGC GAGCTGGTGT TCGGGGCTAA GCAGGCCTGG CGCAACGCTC CCCGCTGCGT GGGCCGGATC CAGTGGGGGA AGCTGCAGGT GTTCGATGCC CGGGACTGCA GGTCTGCACA GGAAATGTTC ACCTACATCT GCAACCACAT CAAGTATGCC ACCAACCGGG GCAACGT7CG CTCGGCCATC ACAGTGTTCC CGCAGCGCTG CCCTGGCCGA GGAGACTTCC GAATCTGGAA CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTGTGC GGGGGGACCC AGCCAACGTG GAGATCACCG AGCTCTGGAT TCAGCACGGC TGGACCCCAG GAAACGGTCG CTTCGACGTG CTGCCCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCTTCC~rCT GCCCCCCGAG CTGGTCCTTG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GGTTTGCAGC CCTGGGCCTG CGCTGGTACG CCCTCCCGGC AGTGTCCAAC ATGCTGCTGG AAATTGGGGG CCTGGAGTTC CCCGCAGCCC CCTTCAGTGG CTGGTACATG AGCACTGAGA TCGGCACGAG GAACCTGTGT GACCCTCACC GCTACAACAT CCTGGAGGAT GTGGCTGTCT GCATGGACCT GGATACCCGG ACCACCTCGT CCCTGTGGAA AGACAAGGCA GCAGTGGAAA TCAACGTGGC CGTGCTGCAC AGTTACCAGC TAGCCAAAGT CACCATCGTG GACCACCACO CCGCCACGGC CTCTTTCATG AAGCACCTGG AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CTGCAGACTG GGCCTGGATC GTGCCCCCCA TCTCGGGCAG CCTCACTCCT GTrTTCCATC AGGAGATGGT CAACTATTTC CTGTCCCCGG CCTrCCGCTA CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC CAAGGGCACC GGCATCACCA GGAAGAAGAC CThJ7AAAGAA GTGGCCAACG CCGTGAAGAT CTCCGCCTCG CTCATGGGCA CGGTGATGGC GAAGCGAGTG AAGGCGACAA TCCTGTATGG CTCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT TCCGGAAGGC TITGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC GCTGGTGCTG GTGGTAACCA GCACATTrGG GAATGGGGAT CCCCCGGAGA ATGGAGAGAG CTYJTGCAGCT GCCCTGATGG AGATGTCCGG CCCCTACAAC AGCTCCCCTC GGCCGGAACA GCACAAGAGT TATAAGATCC GCTTCAACAG CATCTCCTGC TCAGACCCAC TGGTGTCCTC TrGGCGGCGG AAGAGGAAGG AGTCCAGTAA CACAGACAGT GCAGGGGCCC TGGGCACCCT CAGGT[CTGT GTGTTCGGGC TCGGCTCCCG GGCATACCCC CACYITCTGCG CC1T[GCTCG TGCCGTGGAC ACACGGCTGG AGGAACTGGG CGGGGAGCGG CTGCTGCAGC TGGGCCAGGG CGACGAGCTG TGCGGCCAGG AGGAGGCCTT CCGAGGCTGG GCCCAGGCTG CCTrCCAGGC CGCCTGTGAG ACCTrCTGTG TGGGAGAGGA TGCCAAGGCC GCCGCCCGAG ACATCTTCAG CCCCAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA GTrGCTGCCA GGTCTGATCC ACGTGCACAG GCGGAAGATG TrCCAGGCTA CAATCCGCTC AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC GCCTGGACAC CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGOGACCAC ATAGGTGTCT GCCCGCCCAA CCGGCCCGGC CYI7GTGGAGG CGCTGCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT GCGGGACCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTTCT TCCTGGACAT CACCTCCCCA CCCAGCCCTC AGCTCTTrGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG GGAACAGCAG GAGCTGGAGG CCCTCAGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG

GTTCCGCTGC

CTCACCCAGC

AGATCCACCT

CTGCTCCACG

TTCCGGCTC

GGGGATTCTG

GTTFCGGCTGC

GTGYI1TGGCC

CCCACGCTGC

TGCCTCTGCT

CACTGTAGCT

TGGCTAAGCC

CACCCGATCC

GCAGGAGCGG

CGATGCTCCC

GAGTCCTCAC

TGGAGGTGCT

CCAGCCCCGG

GTGCTGGCAT

AGCTCAAGCC

CAGCT-rGCCC

CTGCATGACA

AACTI'GACCA

CGCCTTCTCC

GGAGCAGTTC

TACTACTCAG

ACAGGACTCA

CCGTCGGTGG

TCAGCTCGGC

GGATGGGCTG

CGCTGCCTGC CCCACTGCTC ACCCAGCACC CACCCAGGAG GGCCCCCTGC ACTATGGAGT TCATCCGGGG GGCTCCCTCC CACTGGCAYIT GCCCCCTTCC CCCACTCCCA TGACTGGT CGGAGACCCT GTGCCCTGCT TGCATCCTGG TGGGTCCAGG TTGAGAGCAA AGGGCTGCAG TCTCTACCGC GACGAGGTGC AGAACGCCCA GCAGCGCGGG CGGGAACCTG ACAACCCCAA GACCTACGTG CAGGACATCC TGAGGACGGA GCTGGCTGCG GAGGTGCACC GCGTGCTGTG CCTCGAGCGG GGCCACATGT TGTCTGCGG CGATGT-rACC ATGGCAACCA ACGTCCTGCA GACCGTGCAG CGCATCCTGG CGACGGAGGG CGACATGGAG CTGGACGAGG CCGGCGACGT CATCGGCGTG CTGCGGGATC AGCAACGCTA CCACGAAGAC A1TICGGGC TCACGCTGCG CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAGCTTT TCCTTGCAGG AGCGTCAGTT GCGGGGCGCA GTGCCCTGGG CGTTCGACCC TCCCGGCTCA GACACCAACA GCCCCTGAGA GCCGCCTGGC TTTCGCTTCC AGTrCCGGGA GAGCGGCTGG CCGACTCAGG TGCGCGCGAC CAGGATCAGC CCGTCGTC GGCTCTTGAO GTGGTGGCTT CTCACATCTG TCGAGAGGT GCAAGGATTC AGCATTATTC CTGGAGGAAG GAGCAAAACG CCTCTTTTCC CTCTCTAGGC CTGTTGCCTC GGOCGTGGGT CCGCCTTAAT GTGOAAGGCC CCTCCCAGCA GCGGTACCCC AGGGGCTACT GGGACCCGCT TCCTGTTTrCT TAGTCCGAAT GTTAGATTGG TCTTGCCTCT GTCAGGAGTA TCTTACCTGT AAAOTCTAAT CTCTAAATCA AGTATTTAT-r ATTGAAGATTr TACGATAAGG GACTOTOCCA GATGTTAGGA GAACTACTAA AGTGCCTACC CCAOCTC-3, (SEQ. ID NO:3003) Human Factor Related Anti-sense Oligonucleotide CCT TCC TOG TCT OTC TGC CBG BCB BBT UTG GOB BGT GBB CBG TUT TOG BBC CBT OTT TCC CBG TCT CTO BG TOT GOC 0CC CTO CTO CTC TTT CTG CT TCC CTT GOT 000 TTG GG C OCT GOT TOT TCT 000 OTT C TrG CTO CCC CTT GTG TCC C TOT TTO CTO OTO TCT OCO C CCC C1BB CBG BBG BBO CR0 BCB BBT TTG GOB BOT ORB CR0 TYET TOG BBC GBT OTT TCG TOT OCO CTC GOC CG OTC CCO 0 000 TCT CCT CTT OTT OTT GC TTG COC CTC CG CTG 000 OT CC CTC TOT TCT TOT TTT 000 GG 000 CCC GOC COT TOT CTT 0 OTT TOO 000 TTT CG TTO 000 TTrC TCC TOG CCC 000 CCT TOC CC GG GT GOT CCC GG TUC OTTCCT GTC TCC OTC TCO OCT GTTr CTO 000 CCT TOC OCT GTC T-lT GOT 0 GCB CG TCC BOT GBT GOT OCO GTB CUT OTC OCT 0GB GO GTG GOC CTG OTC CG GBO BOC OCO COG 0CC 000 GOC TOC TOO 0 GOT TOO CCC 000 OTO CCC C 0CC OCT 000 TG GCT COT GGT GTG COO TCGOTO TGT CCT GOC TCT GOT TCC CC OCT OCO CCC OTT OTG GTC TOO GOT GG GTT C OCT CCC 000 TGT GOT TGT TOT OT TOO 000 TGG CUT TTT 000 CGT OTT OT GG OTO OCT TOT OTO UTC GOT TTC TOG GCT OTG GTC COO GT CCC COG BG CTC CCC 000 0GB GOB TOB GTT TTO BOO 000 8GB CBG BTG TCT 000 GBT TG CG OTG CTO GOB B OBO CCC GB 0GCB GOB CCB GOB TO COG 0GCB GO COG 0CC 000 GOC TG TOO OBO GGB TBO GB CGC TOB 0 GGT CUT UC TOT TTU TGC C GTC TG GTT TOT UTG GOT TG CUT CGT TTG TOC TTG UGC C CTO TOT CTC GTG TGT GCG GTT TTU TGT TC GTC UTT OTT OTT TTC TGT TGG UTG GTG BOC BBO BTB TGT BOB TTrC TOG GOT GOT GTCGBT TTT BBBB OCT TOB OBB OCT 0GCB BBC BiT BTG GBB BOT BTB TTT ORG OCT GGB BOO BTC BG BCC BTG TTrC GGB GOC RUT TTB BOT TG TOT GT BBO TOB ORG GTG BOB ORB BCT OTO BBO GRB TGB TOB GTTr GBB OBO TTG TIT TGB CCC OTT GTT GOC TTC -17C TOT C GT TOO GTT CTCGOTT GTG CC TOT 000 GT- T GOTT OTG CC CCC TTCGG0 GG TOG TOG GG GT GGT TG GTG CG 0 OTT CUY GG TTC TTC TOT GGG T TOO CTT GTC OTT GTG CC TOT 000 GTT GTCGOTT GTG CC CCC TTCGG0 GOC TOO TG GOC COT CGT TG CTO CG 0 TTU TCT GTT TGG GTT TCT TTT GT GTC GTG UTC CTG GTTTU TTG CTG TTT iT GTG CUT GTT CTG TCC T CUT TTG TT[ TCT CUT TCG CTT TCT TTf GT GTC GTO G TC CUCT TT TTO CTG TTT TTT GTG T- CU C T TCG TTT GTT TTC GTG TOT GTTr OTT CTO GTG CU- GT 000 OCT CG TOT COC OTO 0 OTO COG CGG TOG CC GG GOBB GGB GOTT GOB 0GCB GOB 0GCB GOB COG 0GCB GOC GG TCB TOT TTG GBT COO GBG BO 0GB CTC GTG TOG TTO OCT TGG U-CG0CC GG BGB TG TBO CBG GBB OBB CR0 BOO 000 BBO CR0 UTG GOB GOT OBO BCC CDT TBB TRO OTO TG B TCGCGTUTC GGCCCUTTCO TTGTGCOTTT GGTTTGOGG TTTTTTGTTT OTTTTCTGTC TCGTCTTTG TTGTGGGCT OTGOGBBTUT CTGTGGOOBT GGCBTBGBCG TBGGGBGGTC CBBGGTBG GBBBGTCBBB TGCBGBBGCB TGCTCBTGGC TTGORBCGG TGGGAATUTC TOTGGOBTO OCATACACOT AGGGAGCTGG AAGAGGTAOC AAACTCAAAT GCGAAGGATG GTGATGGTG TOAAAGG GOGGOTOOCT TCCGCCOCG TCTCTGOOCG GTCCCGTGGG

TGGGGCGC

GOCGCTGCC

OCOCGGGGC

OCTGGGG

GOGGOTUTCT

OGUTOTGCT

GGGCCTCTCC

GCTUTTTGC

AGCGOGGUGO

GATGGUTCCT

GTGCGCBGGG

CCOBCGGCCB

GOTTUGOBOT

BBGBBGGTGG

TOBGBTGUT

GCGGTG

TGCGCOCG

GTGTGCGCCT

CGOCGGGGTG

GGCCOTGGG

CGGGGCTGCG

TCTCCTTGCT

TCTTCGTCCT

GGCGAGCGCG

GGTCGGTAG

CBGGGCUTG

GTCGTGTGC GTGTOGGG GGTGGGGCG GOOCOGCO OTGCOGC

GGTGGCGGCT

GTGCGOGCGC

CTGGGOGTCC

GTCUTGCCG

TOGGTCG

CGTCCTG

UUTGTOGO

GCTGOCGGTC GOCTGCOCC TOCTOOCTOC GGTOCTGGCC TTGTCGCTGG CTTGTCTTCG GGCTGUGCTG GTGGOOTGOG TCOGGOOGGG GGTGTTCG GOCTGTCTC GCTGCGGOGC GCTCCGOOC TGGTGTGT CTTOCCUTCC UfCTCTGGTG OCOCCCOUTT GTGTTTTGTG TTUGGCCTG GGGTCCCTGT CTGTCCTTTG TGOGGCCTC GGTOCTGCTC TTGOTI'TTGG TOOOCCTCG GCACGCCTGT TGGCACGTCG TGCGCAGGOG GCTGCGGCG CGCCAGGAG GGCAGCCAOC AGCGGGCAGC GAGTGGATGG TGGCOCAGAG OCOGACAGOC GCBGCTC GGGGCBGGC GTCGCGOG GOGCCBGGB GGGCBGCCBO GCBTGCUTCC TGCTCGGCTB GGBGTGCBTO GTCCGCGB GGCGGBGBGG C BTGTCTTUBT GBGTGBGBT CTBRGU-CU- TBGBGTCCT TGGBBBBGT BGBBBTCBGO BBGGCTOGCB BGBOBOGGBG GOCCBOCTTO OBBGTGRTGT GGTTCGGGO U7GTGTGCTC TGTOTCTGT TGGTTGGTTG CGGTGGUTTC

GACOGGAG

TTGCGBCGTC

GBGCOCOGBO

GGOGTGGBBB

GCBGGUrCBC TrBGBGBCBG U7CCTGOGTC TTGTCCYT-C TCUOGG GGCT TOG CGOBOTOOG GGTCCTGGBC GGCBCTGBBG GCBTGCBGGG GTTTGUGB

OTGGUCTG

TBGBBBGTBG

TGTGGGTOG

GCGCTrGC

GCCCCBTCC

GGGGAGCAGT

OTGGTGGTT

GGGGGCBGCB

TCCGCTGCCB

GBGGGGGGCC

CTTTCGTCCT

UOGGTTGT

GGCTTCTCTC

TGGGGCGCAA

CATAGTCCTC

GCBCCGGUTC BUGGCBGBGG CTGBTGGCGT TCGBGGBGGG BGRTGGTGGT TCTTGTCGGC GGOCTOCTO CTGGGCTGTT CT]TfTGTTT TlTITT GCGTCCBCCB GGGBGBTG TGGGCGTG GTTGTGTG TU7GGGCCTG AGGCCCTCTG GU-CAGGUGC TGGCAGGGAGTT TOTOOTOUTT GGAG1TT7CCA TCCCGGCU~C

GGBCGBGGOB

TGCCTCTCTG

GTGGCGTGGT

GTCiTTTGTTT

GUGGUTTO

GCATCCCGATA

TCTGTGOTTrC

BGUTGCBTCC

GBTGBUTBGG

GGTTU17GG

GCTCTCTGGT

GTGGGCTGGT

GGTGTTGAGO

OTGAAAGTCT

CAAGGGAGB

CCBTBGTCBB GTTGGOGGGG BBBGGCGGTG TGGTTGBGGT TCTGGCBGG BGTTGTTGT CGGTTBTBG TGCGTGGTGTTTOOBOT UTCCBTCCG GCUGfTCTGT OOTTCGBBGG GB OOGCBGGGGG GBGTGOGCOG GCBBTOTBOO GBBBGCBGCB GTOTOOTO TGGGBGGBBT BTOGGGBGGC BOBTOCROOB GCGCBOBGOO CGTBGCBBT OBGGBTGRGB OCOBOOCOTO GGGCGGBGBG CTTGCBTOGTB GCGTTOBOB OOCTGTGGGB GOGGOTOTOG TGTCGGTTO GCOGTTGTTT GGGGTGTT TTGTCTOOOT TGGCGTGCTG CTCGTCGTGGT COCTCGOTC CGGGGUCOT CTGTCTOT GCGGGCTTGC TTGGUTGTG 72 TGTTCCTCCC TTCCTTGCCT CT GBTGTTTGT- BCCBBBGCBT CBBGBBTBGC 1TFGCTBTCT BBGGBTCBCB TTTBGBCBTB GGBBBBCGCT GTBGGTCBGBB BGI3TGTGCTT BCC'IrCBCBC BGBGCTGCBG BBBTCBGGBBGG CTGCCBBGBGBG CCBCGGCCBGC TTGGBGTCBT GTrTBCBCBC BGTGBGGTGC TCCGGTGGCT TTTTrGCTGT GTGCTCTGCT GTCTCTG UTC CTTCCGGTGG TTTCTTCCTG GCTCTTGTCC 1TTTCTCTTGG CCCTTGGCCC CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTGG CTTCCTGCBC TGTCCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGCTTrCB TGGGGCTCTG GGTGGCBGGT CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG GCGGTCCBGCCBTGGGTCTG GGGGCTGGG CTGCBGGCTC CGGGCGGGCG GGTGCGGGCT GCGTGCTGGG GGCTGCCCCG CAGGCCCTGC GGTCCBGCCB TGGGTCTGGG GGCTGGGCTG CBGGCTCCGG GCGGGCGGGT GCGGGCTGCG TGCTGGGGGC TGCCCCGCAG GCCCTGC GCBCCGCCTG GBGCCCTGGG GCCCCCCTGT CTTCTTGGGG, BGCGCCTCCT CGGCCBGCTC CBCGTCCCGG BTCBTGCTTT CBGTGCTCBT GGTGTCCTTT CCBGGGGBGB GBGGGGCTGG TCCTCTGCTG TCCTTGCTGG TGCTCBTGGT GTCCT117CCG CCCTGGGGCC CCCCTGTCTT CTTGGGGCCT C117CCCTCTG GGGGCCGTCT CTCTCCCTCT CTTGCGTCTC TCTCTTCTC TCTCTCTCTI' CCCCT-17CCC GCTCTTTCTG TCTCGGTGTC TGGT-rTTCTC TCTCCGCTGG CTGCCTGTCT GGCCTGCGCT CTTGGCCTGT GCTGTTCCTC CTCCGGTrCC TGTCCTCTCT GTCTGTCGCC CCCTCTGGGG TCTCCCTCTG GGTGGTGGTC TTGU-GCTTG GGCTGGGCTC CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGCGCTG GTCCTCTGCTGTC CT-rGCTGGTG CTCBTGGTGT CC1TTTCCGCC CTGGGGCCCC CCTGTCTTCT TGGGGCCTCT TCCCTCTGGG GGCCGTCTC TCTCCCTCTC TI7GCGTCTCT CTCTFITCTCT CTCTCTCTTC CCC1TCCCG CTCTUTCTGT CTCGGTGTCT GGTfT1CTCT CTCCGCTGGC TGCCTGTCTG GCCTGCGCTC TTGGCCTGTG CTGTTFCCTCC TCCGGTTCCT GTCCTCTCTG TCTGTCGCCC CCTCTGGGGT CTCCCTCTGG CGTGGTGGTC TTGTTGCTTG GGCTGGGCTC CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGC CTGCTGBGGC TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG TTCCTCCT[G BTCTGGTCGCT GTCGTBCCBG TCGGBCCBGT BBTTCBGBTC BTCBTTGGCT CCTB'rrTCTT CTGCBBBCBG CTGBGTGGBG BCBBGBBBBB BGBCTGCCBB GGCCBCGBGG BTTTCBTGT TGGB1TTTGC GBCGGBCBGT CCCGCGGGGT GCTGAGTTTC TCTGGTTCCT CCGBGCGCBC GTGGTCGCTC CGCGTTTCTC TGGT-CCTCC GGTCCCGCGG GGTGCTGTCT GGTCGCTGTC GTGGC'rfGGG TCTCCGGGCG GTTTCCTTCC TITTCCGC CGGCCCTTCT CACTGGAGOC ACCGGGCAGT CCTCCATGGG AGGGTTGGGC TTGGCCGGGG CTGCCCGGTG CCTCCTCTTG GCTGGTCCCT CGTTGTCCT[ GGGCCCCGC TCCCGCTGCT CGGCCTCCGT GTTCTTTGGC CTCTTGCTCC GCCTGCTGTC TfrGTCCCGTC CCCTCCTCGC TTGCGTTTCC CTC'rFCC'1rG TCTrCCAGGC C11'CCTCCGC TUCCGCTGCT GGGGCCCGCG CCGGGGGGGC GCTCGGCTCC GCGGCTTCCT CCCCGGCTGG GGGGTCCTGG TCTCCGGGGC CTGCGGCTCG CGGGCTCGGG GCTGCGTGCG CCGCGCGCGG CGTCCGCGGT GGGTGGCGCT GTCCCGCCGT GGTGTGTCTC CGTTCTCGTC CTGCGCCGTC CTGGTCTGCC CGTGGGGTCC TGGGCGTGGT GGGGGGCGTC TGGTGCCTCG TCTGCCCCGT GGGGCTTCGG GCTCGGGGCT GTTCGTCCCC CCTGCCGCTC TGTGGCCTCC GGGGCTCCTC GTTTTCGCTG CTTCGGGTGT CCTTCTCGGC GTGTGGCCCC GGGTCCCGGC CCTGCTGGGC TGGGCGGGGT CGCTGCCCTG GGCTTCTGGC CCGTCTGGTT GTCTGTCGGT GCTTGTCTCG GGTTTCTGGC CTCTGTGCTG GGCGC11TCTC TGCCTCCTGC TCCGCCCTCC TGGTGGCTCG GCTGGGGGTG CCCGTGCGGG GGTGGGTGTG GGGTGTTUTC GGGGTCCTCC CC117CCC GTTr TCA TCT TGG CTT TAT CCTCT CCC CiT OTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C T-rC CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC 117G TTG CCC TGG 0CC Cii' CCC TGC TGG GGG GGA GTT TCA TCT TGG GTT TCB TCT TGG Cii' TBT CCTCT CCC GilT GTT CCT CCC CTCT CCT GCT CTG ORG TCT CCT C 'FTC CCT CCC TCC CCT 0CC GTG '117 TCT GTG GGT GTC GTT TCG CTC iTT 1170 CCC TGG GCC Cii' CCC TGC TGG GO GGB GTT TCB TCT TGG GG GGB OTT TCB TCT TGG Cii' T CCGTGTTGTC BGTGGTGCTG CCCGTTTGBG GTBTGGCGCT CCBCCBBTTC CCTTTTCTCC TTGTTTTCCG TTTCTCTTGC CGTCTGTGGT T GCTCAGCCTC CAAAGGAGCC AGCCTCTCCC

CAGTTCCTGA

TGCTTACTTT

ACAA'ITGCGT

CTGTTACAGA

ATGAACTTTT'

TTrGCATCAGT

TTGGGCCCCA

AGCACCAAAT

ATCTGGTGAA

AGGTCATCAG

TAAATAAATT

T-rCACCAGGA

CACAAGGAAA

T-TGTii'AGCA AATCCTGAGT GTJTGCCTGCC AGTCGCCATG AGAACTTCCI TGTCTGAGAT GGCCTCAGGT GGTAACTTTC TCACAGGCCT CAGCAGTGGA GGGCAATGTC TCTATTFCTGC CTGCCCGATC GGGAAGGCCA AGTGCTGCAA GTGAGCTGGG AGTGACCAGA 1'ATAAGCAYT CTTTTAATAA AGGAAAATTG C'TTTGAAGT AT

CACACCATCT

TTGTAATGGC

T1'TACATCTT

AGACTGTGGG

CAGCAAGTGA

ATTAAT17AG

AGAAATAGTT

CAAAGCCCTG

GT*TCTGACAG

'TrFGTTACTT TGGACTTCCC CAGCTATGTT TACAGCCTCG ACAAAAAGTC TACACTTTGA TACCATCACT TCAAGTGAGG TGAGGAGCCA TAATGGAAGC ATTTCTGTGG GGTGCTGGCA GAGCTGCCTC TTACTTITCTA AAGGTGACAT GTAGAGCACA TAAAGGC'IT AiMCATAiT TTAGTGTCAG GAATGAATGA GTCTGCCCCT ACAATCAGAG TGACTCCCTG GTGACTAAGC CAT'ITGACCC AGCCCTCTCT CTGCATATCC TCTTGCTCTG TCGGAAGCGA CTCCTGTGCC ACCTTCTGCT GiTFACTCTC TGGCCACAGA TCTGATCATT TTTACCAAAA TTCAAGGCAC AGAAATGACG CAGAAGTGAA ATCCTTUAAG TCAATGGACT CAATAATTAC TGTTCTTCCC AGCATTAAGG CTCGGACATC GTAGCCTGGA CACTGGTCTC GOACATGTOC ATGGCGAGGC AGCAAATATA CAAAAAAAAA CCATTTCTCT GTATGCT'17C CAATTCCAGC CTGCTCAACA TCCCAGTCCT GGATGCATAT CATCAGAACC TCTTTTT TCAGCCTCCC AAATACCTGG 'TM1T[FCTT TGAGACTGAG AATFTATAGGC GTAAGCCATC ATGCCTGGCT AAT1TM'GTA I TTTTCATGG AGATGGGGTT FI'GCCATGTT GGTCAAA'I1TG GTCTCACACT CCTGACCTCA TGTGATCCAC CTGCCTCAGC CTCCCAAACT GCTGGGATGA CAGGTGTAAG CCACCATGCT AGGCTCAGAA ATTTCCTTr ATAAAA-ATGT CATTAAGGAT CTTGGCTGCA CAATATCGii' ACCAGCTTCC 'TTAAATCCA CTTCTGGCCT GCCAGGAATC AGGTUCTTFCA GAACCTGACA TT1TTAAATGA AGAGGTCAGG CAGTTCATGA GGAAAGCCTC ATTGTCCCCA TGTCTCTGTC ACTOCTOCAC CCCTGAGACA TCACAGACAT GGACACTGGG GCCTGCTTGT TITCTCAAACT GCCC'ITAGAT CGAAAGAGGG AGGAACCAGG ATGAATGCCA CTCA'TTTTCC CAAGAAAGGC CCTCTCCTGA GTOCCCGGGA TGGGGCTCTG TCCA'11'GCCT GGGGCCGCCA ATTGCTACTC TGGGTTACGG AGGAAGGACA GGGTCCTGAG AGACACCAGA GACCTCACAC AGCCCTGAAA ACATGGGGCT CC117CATAAG TGT7TCCCAT CACCAACAGG GAGACCACOT GGAGGCCTTG CAGCCCCACT CGGTGCTTCT CCACCAAATC CCAAGGGCAG TGACGCTGAC GTCTGTGGAA AGCAGAGAAA GCCCTGGCTC CCAAAGCCCT GAAGTCCCTG TGGAGCTGAC ATrCCCTGAG TGACGGTGTG AATGGAAGGA ACTCAAGTGC GGGTGGTAGG CCACCTCCTG GCCCAGGCCT GGGTGAACTC TGAGGGGACA CATGTAGTCA CAATCCCATC CTCCCATTCT CCTTCTGAGA GGAAGGAAGT GGGCATCCAT CTGCCTCATC TCTCTCCCGT GGGGAAGATG GGGAGTTTCA GGGGAACTTT CACATAAATT TCACCAGCTC AGATCTCCTG TGAGGATGGG GCCCACCATG CTCCCGGTGC TGCCAGAGGC CCTGAGCCCC TCCCAGGGTC CCTGGGTTTG AGCCAGCCCT GTATCATCCC CAGGAGCTGA ATGTCAGAGC AATGGATAGA AT7AGATGGA AAGAGCTCTC AATTTGACCT GAGACTGTCC CCAGATACTC AGGAAAAACA GGACGTCGCA CAGAGTGGGC AGCAGGTGAG TGGCAGGT-FA TAGGTCCTGA GTTTGAGTTT GTTCTCACGT GAGACAGACC CAGCCCCTCA CTCCATTCAC ACACTGGGTT TTAAATGGTG CAAGATAGGA GCAATTTTCT GGTCCCAAGA GCAGGAGGAA GGGATTTTCT GGGGTTTCCT GAGTCCAGAT 'FrGCATAAGA TCTCCTGAGT GTGCATTGTr CTTfGAGGAC CATTCTCTGA CTCACCAGGT AAGTGGCTGA ATTCTAACCT CTGTAATGAG CA17GCACCC AATACCAGTT CTGAACTCTA CCTGGTGACC AGGGACCAGG ACCYITATAA GGTGGAAGGC TTGATGTCCT CCCCAGACTC AGCTCCTGGT GAAGCTCCCA GCCATCAGCC ATGAGGGTCT TGTATCTCCT CTFCTCGTTC CTCTTrCATAT TCCTGATGCC TCTTCCAGGT GAGATGGGCC AGGGAAATAG GAGGGTTGGC CAAATGGAAG AATGGCGTAG AAGYFrCTCTG TCTCCTCTCA TTCCCCTCCA CCTATCTCTC CCTCATCCCT CTCTCTCCYr CCTCTCTCTG TGTGTCCCCT CCATCCTTTT CTCCTGCTTC TCTCTCTTCT TCCCTCTCTC TCTYTTTCT GTCTTTCTTT TTCCTCTCTC CCTAGAGCAT GTCTTTCTTT CTTTCTCTTT CCTTTCTTCT ACCCACACTT T[AGACTGAA TGCCCTATTT AATTGAACAA AGCATTGCTT CCTrCAATAG AAAAGGAGTT TGAGAACCCA ATGGACACCT CACTCGTTCT TCTAAGCCAA TATGAAGGAG CCCAGTAGCT TGTAAATATC ATCTCTTCAC TGCTTTCCAT GCTACAACTG CTGAGACTAT GGTTGAAACC TGTTAGGTGA CTTTAAAT AAAAGGCAGA AATrTTGATT TrATCTAAAG AAAGTAGTAT AGAATGTCAT TTTCTAAATT ThUATATilTA AAGGGTAGAT ACTGCAACCT AGAGAATTCC AGATAATCTT AAGGCCCAGC CTATACTGTG AGAACTACTG CAGCAAGACA CTCTGCCTCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG TACAGCCCAT TGAAACCTAC TYITAAACCT GGATGCCTAA CCY[CATTTT CTCCYITGATA TTATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG GAGAGTGGAA GGGAAGGATG GAGAAAGGGA AAAAGAAAAT ITrGAGAGTAA ATCCTAAAAC AATTAATCTA ATAGATATCA TCTTGTGAAA TCCTCA1TUT ACCAATCTTA TTTATGAGTC CTGGGTTT7G TGAGAACAAT GGGGTTCTGA GAGGCACCAG AGACCTCATG TTTITCCAAAA CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAGGGAG GCAGGGAGGC AGGGAGGCAG GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG GGAGGGAGGG AGGGAGGGAG GGAGGGATAA AAAAAGAAGA ATGAGGTTGA

AACCAGGACT

GTAAG'ITACT

CAAATACTTA

ATGGTGGCTT

GACCCCACCT

ACATCCCCCC

CATTATCATG

ACAGGGTT-fG

CCCTGTTAGG

AGTCTTUTGC

CCATGAGGAG

ACATGTAAAC

GTGATGTTGG

AGGGCTGCCA

CYITCCCCATT

CCTCACCTAC

AGTGGATCTG

T-rCT-rATGCA

ACTAGCCACA

GCCACAGGGA

CTATTTACCT

TGTACTGGCC

TAGATATTAG

TGGTGTI7AAT

ACAGACTAAA

TGATATTATC

GGAGGCCCCA

AACCACAGCA

ATGGAAAAGC

TGTMITCCA

TGTT1TTTGGT

CCTAGAAGGT

GCCAAGAAGC

CAAATTAAAC

TITTGGGCAGG

CAGCGGGGCYI

TATTCCCGGC

CCCACATCTT

AAACAAGCCA TTACAAAATT TATTTCTATG TrCCTATTAA ACAATTTCAG TAAGTTGCAT TGATTI7GAAA AAGCAAAAGT TTACTGGCTT TTCTTGTGGT GGAGCTGAAT TCACAAGAGA

GTCACTCAGG

GTGCCAGTTT

CCAGGCTTGA

ACATGAGTUT

GGTATAGGCG

ATAAACAAAT

TGCTGTGGCT

TATGGTGTCC

CCATCTCTAA

TGGAGTGCTUr

ATFITTCCTAA

CCCTAAAAAA

AGAGATCAGG GTCTTTCACA CCATGTCAGA AACTTAGATC GAAAGAAGCC CGCTGCGGAT TGAGTTCTTA CACGCTGTTT ATCCTGTTAC CTGCCTTAAG

GTTAATTGTG

C1TTTATCC

GTGTGTGTTA

TCGTTGCTGA

ATCAGGTTCT

CAAATGACTG

TTACTCAAGG

GCTC1T1TTG

AGTGGAGCCA

GTTTTCAACT

CATCTCAGGT

AAATGGAGGT

GCTCCTACCA

ACAAAAATAA

ACTCGCGTCT

CGATACTGAC

TGTGTTT-TT

TATGTCATCC

CTGCAAAAAG

GAGACGTGCG

TGGTCATTGG

GGAAGGGGTC

ATTCCTTGAC

CCTYFGCATGC

ATGGAATCAT

TGGCACCTGT GGTCTCCCTG GAACAAAATG GATGCGGATT CAGAAAGGGC TCCCTCATCA AAAGATACGC AATCTTTATC CTAGTAATTG TATCCTTGAA ACACCT=T1 CTGCTCTCCA TCCAGGGTCA CAGGCATCTG TATTCTTTGG AACGTGTGCT TTGCTCCTCC TGCATCCTCC AGCAAGCCCA ACTCAAAGAC CAGTTCCCTC CCAAGGGAGG GGATGCCCAG TCCTCTGTTC TTCACAAGAC TCCCTTCTTC TGGCTAAGGT ATrAT CTGCAGTGGT AAAAAGATTC TATATCTGCT GT-rTGATGAA TGCAGCACCC TAGTGCTCGT GAGCACTTGC GCATGTGGCT GCCATATTGG TGGTITGGCGG AACACATTGA AACTTAAACA CATCCACAGG GAGGACAATG AGAAGAGTTT YTCAAAAGTG GTTACTGATG AGACAAYUTC CATCGGTGTG ACTGTCTCCT AGGGTAGCGA TGGCCTCTTG CCCATAAACA GACCAGGCAG 1TITAAACAAC CGATCAAGGT GGAAGCAGGG U-GGCUTCTT CCTGGGTCCT CACATGGTCT TTCCTCTGTG ATGGATCAGA GCACACCCCA ATGACCGTGT CAATCACCTC CTGAGGCACT GTTAGGGCTT AAAACGCCTA CCAGTGGAGA CTTGCAACAT TGT7CCCTGT TGCATGGAAT AGAAGGCTAT GAGAAGGGCA AAATAAAGTC CAAGTAGAAA

AATGCGGCTA

ATGGTGCTGC

AGGGACTCTG

AGAATGAAGA

GAATTACTGC

AAAGCCATCT

TAYUAGTCCG

AGAAATTTAT

CTCAGGTGTC

TGTGTCTGTC

TTAACTTGAA

CGACACAGGA

GGCGGCCTGC

TCCAGAGTAC

AAAAAACTAI

GGGTGATTC

TTTGAGAACA

TATTGATACC

GGTI1'GGGAA

AAAAAGTGGA

TCCAACAGA

CTCAGGCTAC

TUCCTCGCAG

TGTCCTUGGC

CCAATCTCTT

TCACCTCTTT

ATTCTT[CC

TGGTCCCTCG

TGTCTCTATT

AATTAACCTA

AAATGAGAGA

AGGC'FUCAAA

GGGACCAGAA

AAAATAGCCT

GATCTGCAAC

CAGATTTATC

TCCTGGAGGC

TGGTAGATGA

CTTATAAGGA

AAAGTT17CTC

TAGGGGATTC

CCAGGAATAT

TATCAGATCT

AAAGAGAACA

AATGAAGCCT

CTTTGGGAAG

ACCAGGCATT

TTrGGATGGAA

ATGAGAATGT

GITTAAACTG

AGGAAGTCTG

CCGCCGCCTC

TGCAAGTCTT

TCTCCAAATA

AGUrCAGTCC

CACAGGCGAC

GGGATACTGG

GAAAGTITA GAGAGTAACC ATAATTTCAG CCCGATGTGA AACGATCCTA GATTTCAGCT GAAATAGTGA TGTGGGAAGT GAGGGGGCCG GGA'ITCAAGG CAGAGGGAAC AGCGTAACTG AAGGCATGGA AGGAGGGAAG TGTAGGCTGT GTTI'GAAGAG TGGCAGCTGC YTCCACATTT CTAAAACACA GGATGTGATT TTGGGGTGTG TTGAGACAAG GCAGAAAACT TGTU-GGAAA AATAACTTJGA ATTCCCTGCA CATTTAAAAT CTCTCAGCAG AAGAkAAACCC CACTCAGAAC CCCACTGTTC ATTCCTTGGC TTGTATrTGG SCACAGCTGG CATAGCCCCA GACTGAGTAA GCTCTTCAGA CACCTCATfT CATGAGTAGC CCCAAAGATC AATCATGGGC CAATTTCTTG GAAGAGAAGA CTCTCCGGTG T1TTGCAGTT ATTfrGTTCTG CTTTCGCGAG ATGTTCTCAA ATCGTTGCAG CTACAAGCCA TGAGTCTGAA GTGTTTGTGT TCCCTCCTTA CAGGTGGTAA CTTTCTCACA GGCCTTGGCC ACAGATCTGA TCATTACAAT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT TCTGCCTGCC CGATCTTTAC CAAAATTCAA GGCACCTGTT ACAGAGGGAA GGCCAAGTGC TGCAAGTGAG CTGAGAGTGA CCAGAAGAAA TGACGCAGAA GTGAAATGAA CTTTrITATAA GCATTCTTUT AATAAAGGAA AATTGCT'rrT GAAGTATACC TCCTTTGGGC CAAAATGAAT CTTGTGTCTC AATTGGAAGA GGTAAAGAAG TAGGGGGTTA GGGTGCATGG G17GGAACGT GAGACAGGTC GAACCACAAA GCCTGCCTGG AAAAGGGGAG TGACGTCCTA GGCTTCAGTG ATGTCACCTC CACTTTGTTT GATCCACAAA CCAACAGGTG ACTGATITTG GTCAGCTCAG CCTCCAAAGG AGCCAGCCTC TCCCCAGTTC CTGAAATCCT GAGTGTTGCC TGCCAGTCGC CATGAGAACT TCCTACCTTC TGCTGTTTAC TCTCTGCTTA C1TTTGTCTG AGATGGCCTC AGGTGGTAAC TITCTCACAG GCCTTGGCCA CAGATCTGAT CATrACAATT GCGTCAGCAG TGGAGGGCAA TGTCTCTATT CTGCCTGCCC GATCTTTACC AAAATTCAAG GCACCTGTTA CAGAGGGAAG GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT GACGCAGAAG TGAAATGAAC TiT GAATTCACAT TJTCTCACCTT TTGATGTATT ATTCTAAT- CATCAGTCAG 'TFGCATCAGA GATGATGTTA YUCAGGTTUG GTCACAGGTT CCTCTCTTGA TTTCCACTGG CCAGTACAGC AGCAGTGATA GTTTAGCTCC AATGCTTTTrA TACTTTGGGA CTTCCCCAGC GCATCGACAA AAAGTCTACA ATCACTTCAA GTGAGGTGAG

AAGAAAGTAT

TGITTTTTCCA

CCAATTUCY[

TAGACTGCTT

ATTAGCACCT

GTGCCATCCC

TAT[TATCCT

TATGTTCAAT

C~rTGAAGCA

GAGCCAGTAG

GGAGAAATAT ATCCTCTATC TCCTT-rACTG

TGTCTCCAT[

TTTAAGTTCA

TTGCTAACCT

CCAGTCTCTC

TTAAGTCAAT

AATTACTGTT

TGATGATGCC

TGCAGAAATT

GCAATTACAG

TCTGGAAGGC

CA1TGTGTT TGACTTTrGCA CTTCCC1TTG GGAAGCATTr CTGTGGGGTG GTGGCAGGAC TGCCTCTTAC TTTCTAAAGG CATAAAGGCT T-ATTTCATA AGGAATGAAT GAGTCTGCCC AGTGACTCCC TGGTGACTAA CAGCCCTCTC TTGCATACC TGTCGGAAGC GATTCCCGTG CTAAT1TTTG TAT~rTrTCAT CATGTGATCC ACCTGCCTCA AAATTTCCTT TTATAAAAAT CACCTCTGGC CTGCCAGGAA TGAGGAAAGC CTCAYI7GTCC

TGACATAGCA

T-CCA1T[CT

CTCAATTCCA

GCTCCAGTCC

TTAAGGCTCA GACATCAGCA CCTGGACACT GGTCTCATCT ATGTGCATGG TGAGGCAGGT AGTATACAAA AAAAAATAAA CTGTATGCTT TCTTCACCAG GCCTGCTCAG CACACAAGGA TGGATGCATA TTTGTTTAGC

AAATTTTCAT

CTTTCTTCCA

GTAGCAACCT

CATCAACAGC

TTATTTGGAA

ATTGGCAACA

TCAGTCAGAC

GCCCCATTGT

CCAAAT1TITA

GGTGAAAGAC

CATCAGCAGC

ATATTAATTT

GAAGAAATAG

AACAAAGCCC

AG1T7CTGACA

TTTGAGACTG

GCGTAAGCCA

TGGTCTCACA

AGCCACCATG

GCCTrCAATA

AACITTTTCA

GTGCAATTTC

TAACATCACA

ATAGAGCATA

TCTrGGACAA

CATCTTTTGT

AATGGCTACA

CATCTrTACC

TGTGGGTAAT

AAGTGAGAGC

AGGCAGAGCA

1TFAGTGTC

TGACAATCAG

GCATCTGACC

AGTCTTGCTC

TCATGCCTGG

CTCCTGACCT

CTAGGCTCAG

CCACCAGAAC CTCT-T1 T-TTTTTC CCTCAGCCTC CCAAATACCT GGAATTATAG GGAGATGGGG TT-rTGCCATG TTFGGTCAAAT GCCTCCCAAA GTGCTGGGAT GACAGGTGTA GTCATTAAGG ATCTTGGCTG TCAGGGTTCT TCAGAACCTG CCATGTCTCT GTCACTGCTG

GGGGCCTGCT

TCCCAAGAAA

CTCTGGGTTA

GCTCGUTCAT

TCTCCACCAA

CCTGAAGTCC

GGCCACCTCC

CTCCTfrCTCA

CAGGGGAACT

GCTGCCAGAG

AATGTCCGAA

TGTTTCTCAA ACTGCCCTTA GATCGAAAGA GGCCCTCTCC TGAGTGCCCG GGATGGGGCT CGGAAGAAGG ACAGGGTCCT GAGAGACACC AAGTGTT-fCC CATCACCAAC AGGGAGACCA ATCCCAAGGG CAGTGACGCT GACGTCTGTG TGTGGAGCTG ACATTCCCTG AGTGACGGTG

TGGCCCAGGC

GAGGAAGGAA

TTCACATAAA

GCCCTGAGCC

CAATGGATAG

CTGGGTGAAC TCTGAGGGGA GTGGGCATCC ATCTGCCTCA TFTCACCAGC TCAGATCTCC CCTCCAGGGT CCCTGGGTTT AATTAGATGG AAAGAGCTCT ACAGAGTGGG CAGCAGGTGI CCAGCCCCTC ACTCCATTCA AGGAGGAGGA AGGGATTTTC

CACAATATCG

ACATTTTAAA

CACCCCTGAG

GGGAGGAACC

CTGTCCATTG

AGAGACCTCA

CGTGGAGGCC

GAAAGCAGAG

TGAATGGAAG

CAGATGTAGT

TCTCTCTCCC

TGTGAGGATG

GAGCCAGCCC

CAATTTGGCC

k GTGGCAGGTI

CACACTGGGT

TGGGGTTUCC

ACTCACCAGG

ACCTGGTGAC

TGAAGCTCCC

TTACCAGCT7 CCYTTAAATC TGAAGAGGTC AGGCAGGTCA ACATCACAGA CATGGACACT AGGATGAATG CCACTCAYTTT CCTGGGGCCG CCAAT-GCTA CACAGCCCTG AAAACATGGG TTGCAGCCCT ACTCGGTGCT AAAGCCCTGG CTCCCAAAGC GAACTCAAGT GCGGGTGGTA CACAATCCCA TCCTCCCATT GTGGGGAAGA TGGGGAGTTT GGGCCCACCA TGCTCCCGGT TGTATCATCC CCAGGAGCTG TGAGACTGTC CCCAGATACT ATAGGTCCTG AGTTTGAGTT TTITAAATGGT GCAAGATAGG TGAGTCCAGA TTITGCATAAG TAAGTGGCTG AATTCTAACC CAGGOACCAG GACCU-TATA AGCCATCAGC CATGAGGGTC CAGGAAAAAC AGGACGTCGC TGTTCTCACG TGAGACAGAC AGGAATTTTC TGGTCCCAAG ATCTCCTGAG TGTGCA11TGT TCTGTAATGA GCATTGCACC AGGTGGAAGG CTTGATGTCC

TCTGAGGA

CAATACCAGT

TCCCCAGACT

CCAT[CTCTG

TCTGAACTCT

CAGCTCCTGG

TYrGTATCTCC TCTTCTCGTT CCTCTrCATA TTCCTGATGC CTCTUCCAGG TGAGATGGGC CAGGGAAATA GGAGGG'FrGG CCAAATGGAA GAATGGCGTA GAAGTTCTCT GTCTCCTCTC ATTCCCCTCC ACCTATCTCT

CCCTCATCCC

'UTCCCTCTCT

11TCCTTUCTT

TCCTFCAATA

GCCCAGTAGT

CTG1TAGGTG TrTCTAAAT

CCTATACTGT

AGTCCCTGCC

GATGCCTAAC

TCTCTCTCCT TCCTCTCTCT GTGTGTCCCC CTCTT1TT CTGTCTTTCT lTrTCCTCTC CTACCCACAC TMAGACTG AGTAGACTGA GAAAAGGAGT TrGAGAACCC AATGGACAAC 11TGTAAATAT CATCTCTTCA CTGCTUTCCA ACTI1AAA TAAAAGGCAG AAATFFGAT 11TATATr AAAGAGTAGA TACTGCAACC GAGAACTACT GCAGCAGACA CTCTGCCCCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG

TCCATCCTT

TCCCTAGAGC

ATGCCCTATT

TCACTCGTTC

TGCTACAACT

TTITATCTAAA

TAGAGAATTC

AGGACTTTTC

ACAGCCCATT

TCTCCTGCTT CTCTCTCTTC ATGTCTTTCT TTCTTTCTCT TAATTGAACC AAGCATTGCT TTCTAAGCCA ATATGAAGGA GCTGAGACTA TGGTrGAAAC GAAAGTAGTA TAGAATGTCA CAGATAATCT TAAGGCCCAG TGATCAGAGG CCCTGAGAAC GAAACCAACT T17AAACCTG CTTCATTTTC TCCTUGATAT TATGAAAATA AAATAAAAAC CATGAAAGGA TAAAAGAGGG AGAGTGGAAG GGAAGGATGG AGAAAGGGAA AAAGAAAA'rr TGAGAGTAAA TCCTAAAACA ATTAATCTAA TAGATATCAT CTTGTGAAAT CCTCATTrA CCAATCTTrAT TTATGAGTCC TGGGTTTTGT GAGAACAATG GGGTTCTGAG AGOCACCAGA GACCTCATAT 'FFTCCAAAAC CTAGAACAGT ATAATGAAGG AAGGAGGGAA GGAGGGAGGG AGGGAGGGAA GGAGGGAAGG AGOGAGOGAG GGAGGGAAAC AAAAAGAAGA ATGAGGTTGA

AACCAGGACT

GTAAG'ITACT

TCAAATACTTr

TATGGTGGCT

AGACCCCACC

AACATCCCCC

TCATTATCAT

CACAGGGTTT

TCCCTGTTAG

CAGTCTTTTG

GCCATGAGGA

GACATGTAAA

GGTGATGTTG

CAGGGCTGCC

TACAACCTGA

CTTAAACACC

AGGCTfCAAT

TGCATTCACA

GAAGGATGGA

CACAAGGCTG

GGCCATCTGG

AGACAATTGT

GCCGCGTGTA

GCACTCAGTC

TAGACCCCAG

CCTATCCCAA

CCCTfGGTGC

AGAATCCATA

TAGATATTAG

TGGTGTTAAT

AACAGACTAA

TTGATATTAT

TGGAGGCCCC

AAACCACAGC

GATGGAAAAG

GTGTTTTrTCC GTGTT1T-GG

CCCTAGAAGG

GGCCAAGAAG

CCAAATfAAA

GTTTGGGCAG

AAACAAGCCA TTACAAAATT TATrTCTATG YfCCTATTAA

ATGATTTGAA

C1TCT-FGTGG

AGTCACTCAG

AGTGCCAGTT

CCCAGGCTTG

AACATGAGTT

TGGTATAGGC

TATAAACAAA

CTGCTGTGGC

CTATGGTGTC

GCCATCTCTA

ACAATTTCAG

AAAGCAAAAG

TGGAGCTGAA

GAGAGATCAG

TCCATGTCAG

AGAAAGAAGC

TTGAGTTCT[

GATCCTGTTA

TTGGCACCTG

TGATGCGGAT

TAAGTTGCAT

TTTACTGGCT

TTCACAAGAG

GGTCTTTCAC

AAACTTAGAT

CCGCTGCGGA

ACACGCTGTT

CCTGCCTTAA

TGGTCTCCCT

TCAGAAAGGG

GTTAATTGTG

ClTTTATC

TGTGTGTGTT

ATCGITGCTG

AATCAGGTTC

CCAAATGACT

TTTACTCAAG

TGCTCTTfTT

GAGTGGAGCC

:;GAACAAAAT

CTCCCTCATC

CCTAGTAATT

TCTGCTCTCC

TACAGGGGCT

TGGGTCCCAT

AGGTAGTTCT

AGCCTGAAGA

GTTCTCCGAT

TGAATGCTI7C

GTTTTCAACT

CCATCTCAGA

AAAATGGAGG

AGCTCCTGCC

TACAAAAATA

GACTCGCGTC

GCGATACTGA

GTGTGTYTT

ATATGTCATC

GCTGCAAAAA

AGAGACGTGC

GTGGTCATTG

AGGAAGGGGT

GCACCCCAGA

GGCACCAATG

CTGGATGCAC

GTTGGAGCAT

GTGTACCAGT

TCTGAAGGCC

CAAAGATACG CAATCTI7TAT ATATCCTTGA AACACCTTTT ACAGCGGGGC TI7GGAGTGC GAATTCCCTG TAAGCCCTGT

CCTGTGTCCA

AGCAGCCCTC

CCAAATGGGC

GAAAGCATCC

AACTCCTATG

AGAGGCTGTG

AAAGGCCACT

TTAAGCTTAA

CATCCAGATC

TCACCTGGGT

GTCCTCGGGA

TCTCTTTGCA

AGGTAGTTCA

GTTrGGTTGCT

AGGCGGGCAA

ACAACCACAG

TCATGACGCC

AGACATGATC

CCTCCCAGAA

CAACACCAGC

CCCACCCTGA

CTCAACCCYI'

ATCGTGTTTT

GCAGCACACA

ATGGGCTCAG

*AGCACCACTC

AGATATTGAA

AAGGATGAGG

CCCAGTCTGC

GGATACACCT

AAGCTTTTGC

AGTAAAGTGA ATGCCCAGAC TCCCACCTCC TTTCTT~GGGT

TGGCTAATGC

ACTGTTCATT GGCCAAGCAA TCAGGAGAAC CCAAAAATGT GT7CTCCAAC ATCCCAGCTC CACTGCTrA GAAACACATT GGGCGTATAC TGTGATACGC GCTTrAGCCAC AGCCAATGCA GCCTGGGCCT GGCCAGGGCT T-rCCCACCAA ATTTCTCAAC AAATTAGGAC ACCTCATCCC AGTTCTACTT TAACCTCACC

CCAACAGAAA

GTGCACGGCT

CCTAGCTAGA

CTCCAATCTG

TGTCCGGACC

CCTTCTAAAT

CATTCTTITG

GAGTTG17GG 4 0 CTCATTTCT

GAAGCCACAC

ACATCAATGT

TrTTCAATTC

ATCATGAGGT

AATAAACT

TCATTGTCCT

GATGGTAAGT

TCTAGACCTC

ATCAAAGTGC

CGAGTAACAT

TATACTAGCA

ATGCACACCT

ATCCAGGCTG

GGACCCTCGC

AGCTGATGAG

TGGGACGAAA

GTAACCCCGG

GCTCCTTGCT

GGATCTGTAA

ACCTCTGACT

TCTGGTGACT

ACACATGTCA

AGAGAAACCT

AATTCCTTAT

GGGTTATCT[

TTGTCTATr

CAAAAGCTTTF

ATTCTGAGTT

ATAGAAGACC

GTACTACAAA

GTGGGGCCGC

GCTGGGGACG

CATGTCCTGG

AT-rTAGGTCC

GTATTCAGAT

TITCACTCGGT

TCCCTTAT

ATCCYJ7CTAT

TGGGACAGAG

ACTTAAACT[

CCCAGAGGGA

ATGGCTTCCA

TTGACATGTC

TYfGGTCTGTT

A'TTGCCCCT

TGATTGTTTC

TGCCTGTGCC

ACACTTCTAG

CTCAGACCAG

ACAGGTGATA

CTGTTCCACA

AGCCAAATGG

CCAAATCCTC

AGCCAGGCTG

TCACAGGGTC

GACCAAGGTA

TGTCCTTFGCC

AAAAGACCTT

GACTGCTGTC

TACACTGAGT

CCCAGCGGGT

GCTAACTTAA

CAGTAAGAAG

TTTCAATCAG

TCTGCCATGT

CTTTGCTGTG

TTrTGGTGTCA

TAGTTTATGG

GATAAAGATT

TTCTrGGCCC AGATGATCCT GTACCTCTGG GGAACCACAT TAGCAACAGA AGCCCAGGTA CTTTCATTAG TTTTATGGT CTCTGTGTGC AGGTGGCATrF TCCCAGAGGC CUTAAATATT AACTGTGTTA GGAGCCATTG GATGAGAGGT TCCTCTGTGG ACCACAATTA TTTAATGGAC TAAATAGGGG AAGTCCACTT TGCCCTCTCT GGTCACCCTG 11TTCATCATT GAAGCTATGC GAATCCCTGC TAGGAACGTC TAGAGAAACT CAAGCAGTTT ACTATCACAG GTCTTTrGGAA GTTGTTTGAT 1TrTGCTATT AGGTTTTGCA AATATMCT CAGATGCTTT AGCGTTAAAT TAGCCAAGAA ATCA~rACCT TflTCAGT-[GT TACATTTAGG TAAATACATA CATATATAAA GATGTTCCTA CATGGTGTGA AGTGTACACT ATAAATATAC AATTGTTAAT TGTITACTCAA GTCTAAGTAG AGGTGGAAAT CTTrTTTITTTA CT~fAAACCAC TCTGTGTCAC TGAGCTGATT TCACC1TrTAG CCTGATAAAA CTCCACCCTG ATTCCTACAG GAGACTACTC ACCCCATAAC CTCAAAAACC TCTrCATGAG CACCTGAATC CTGAAGTGAA YFACTCGCTA TTCCATTGGA ACTCATATAG GACACCAGAA CAGAGAACAG CAGGACCCAT CTTCAGAAAA TAAGAAGCAT UTGTTCCCTG AGCCTGTTGA AATCTATT C'rTrGGAA TGTTAAAAAG TGAATCATAA TATTTFAAGCA GGTGAACCCA AGCAGGGTCT TJ7CTTGTCAT TA'ITAGCTCC AACCTAGCAC AGACATTAAA GGTACAGATG TGAAACTGGG AGAACAGGAG CATTCGAGCA ACCTrGAGAC CAATGGGCCT CTCITrATAAA CCTCTCACTG AGATTGAGGA AGGTTTCTTG TCTCCGAGCC TTCTCCCAGT AGAGCTATAA GCTCCTCCCT CCCCACACAG CTGCTCCTGC TCTCCCTCCT CCAGGTGACC CCAGCCATGA CATCCITFGCT GCCATTCTCC TGGTGGCCCT GCAGOCCCAG GCTGAGCCAC TCCAGGCAAG GTTGCTGCAG CCCCGGAGCA GATTGCAGCG GACATCCCAG AAGTGGTTGT ITCCCTTGCA GCTTGGCTCC AAAGCATCCA GGTGAGAGAG GCAGGCATGC AGAGCTGCTA AGTCTAGAGG GAAGGACGGG AGAGAGGTTC CAGAGTTGGG TCTCAGCAGT CTATGTCACT GAGGTGGCT-r CACITAGAAT CTCTGGGCAT TGATTTTCTC ATCTAGAAAT TGAACAGAGA GCCAAATAAA CCTGAGAAAC TTATCTC CAAAGACTTG ATTCCAAGAA ACATCTGTGA AATTCACTAA GTTTAAGATA TGAAGAGACA GACTAGTTAT TrCTGGATCT AAACAAGTAG ACT-rAGT-FGT AAAGAGAACA TTYUrACTCTA TCTACAGAAG AGCTTrAAA AACTGCAGCC AAGCCTGAGG GTAAGTTCAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA ATGAGAGCAA AGGAGAATGA GTCTCAAATT CTGTGTGACA AGCACTGCTC TGCGTGTTrA TTCCTATCGA CTGAGGTTFGT TCGTGCTACC GGCTGCAATG CAGCCAGCAT CACCTGTCAG CTAGCATGTG ACTTCCCCGA GATTCTTIT-r CTFACCCACT GCTAACTCCA TACTCAATIT CTCATGCTCT CCCTGTCCCA GGCTCAAGGA AAAACATGGA CTGCTATTGC AGAATACCAG CGTGCA1TGC AGGAGAACGT CGCTATGGAA CCTGCATCTA CCAGGGAAGA CTCTGGGCAT TCTGCTGCTG AGCTTGCAGA AAAAGAAAAA TGAGCTCAAA ATT-rGCT117G AGAGCTACAG GGAATTGCTA TTACTCCTGT ACCTTCTGCT CAATTTCCTr TCCTCATCTC AAATAAATGC CTTGTTACAA GATTrCTGTG TTTCCACCTC MrAATGTGT GATATGTGTC TGTGTCAAGA CACTTGGGAT ACACGTACCA AAACGCAAAA TCAAATTTTT GAACAATATA CCTACCTJ7GC TATAGAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT GCCTAGCTAG AGGATCTGTG ACCCCAGCCA TGAGGACCCT CGCCATCC'r GCTGCCATTC TCCTGGTGGC CCTGCAGGCC CAGGCTGAGC CACTCCAGGC AAGAGCTGAT GAGGTfGCTG CAGCCCCGGA GCAGATTGCA GCGGACATCC CAGAAGTGGT TGTFTCCC17 GCATGGGACG AAAGCTTGGC TCCAAAGCAT CCAGGCTCAA GGAAAAACAT GGACTGCTAT TGCAGAATAC CAGCGTGCAT TGCAGGAGAA CGTCGCTATG GAACCTGCAT CTACCAGGGA AGACTCTGGG CATI'CTGCTG CTGAGCTTGC AGAAAAAGAA AAATGAGCTC AAAATTTGCT TTGAGAGCTA CAGGGAATTG CTATTACTCC TGTACCTTCT GCTCAATTTC CT'I17 GATCAAAATr

TGATGGTGAA

AAAGAACATA

TTAGAAATCA

ATCCTCTGGG

ATATCTAGCT

GAGTAGCTCA

AGTAGGAAAA

CATTTTCCAA

ATCTTACAAG

AAGAACCACA

TAGGTGGGAT

ATTrGGTGCTA GAGACT-rTTC TUTACCTATT ATGCATTTGA CAGTCTFTCAT ACAAYITATAT TACTGAAAGA TTrCTCTCTAT

TATATAAATA

GGATGAATCT

ATACAAAGTT

GAAGAGAGGC TACCTTTGTG GGGAGGGGAC GAGTGGTAAT GATCTGGATG CTGGCTACAG TTTTCCATGT GTATATTATA CU-CAAAGAA GTTAGCCCCA GCAAGCCTCT GGCTTAATCT TTCACAGGGA AAGYITAGAGT ATAAAATCCA AGCCCGTTTA TTTCT-rGATT CCAGTTCTTA AAGACAGCAT GTGCTTCTAA CACCTGATAC TTTCTTGT AGGAGAAATT TGGTGCCTAT TAAAGATACA GTAGAAAGTA TTTAAAACT TAGAATGGAA GTTACAGGCT TCTTTCTT1T AGTATATAAA TGCACACACA GACACAGCAA CATAAAATGC TGAGTTAAAG AAATCAGACC CAAAAATAGG TGGACCAATT CATGGTGGTG AGTTTAATGC CCAGAAGCGG TAAATAAGGA GATGTGTTGG TTGTAAAAAT GCATT~TT GTTCAGTTAA TAATTTCTCA TGTCACTGTA TGTTACCT TAAGCCATCA GTCATTTACA GAATGAAGGT TTACTGGGTA AGAGTCTCTC AGAAGTCTCA GCA1TGTGTC TTrTTTCATGT ATTGTATCTA CCAGCACTTG GTAAACAGAA TTCCTACCAG GCACCAATAA GTGGGACCAA GCCAGGGGGC AATAGTCTGA AAATAAGTAA TTCCCACAAG ATCTGCTCCT TGAGCCCCTA TGTCTGTTAC TGTTTCTI'CA TITCCTCATCT GCAGAGCCAG CCCTGAGAAG TGCAGACCAA AGCCAGGGAA GGCTCTGCAA AGATGTACAA ATGGAAGTCA CC'FrAATAAC CTCTGACTGC TGCGCATAAT ACATTTCACT CAAAAGAGGG CAACCATCTG ATCTTGACA GCTGGGATAA CTGTCTAGCT TAACTCAAGA TGGAGTAAAG AATACCATTC TGGACATAGG CAAATJTGACT AATGAAACTA ACTATCAACA GAGTAAACAA ATATCCAGAA TCTATAAGGA AGGACATGAA CAGATGCT1r ATCACTAATC AUTAGAGGAA ACTATTAAAA AGTCAGACAA TAGTGGGAAT GTAAACTAGT AACTGCCTTT CAATCCAGCA AGGCGCATGC ATGCATATGT CATCAGTGGT AGACTAGCTA AAAATGAACA AGATCATCAT TAATGCAGGA ACAGAAAGCC TGGACACAAA GAAGGGAACA AAAAAGTACC CATAGGACAC GTTAAACAAT GGAACAGAAT AAATCCACAA AAACAAGCAA ATATACAGAA GATfGAACCT ACTTAAATCT AAAACCAAAC ACCTGGCAAA GACTrFCATGA ATGAAACTCT TTAGTTGTAC CCTACAGAAT GGAAAAATTT ATTTAAACAA ATTTACAAGC TCAAAATAAG ACATTCACAC TACAAATCAA AAGCATAATA TAACAGATGC TGGTGAAGGT TCAGCCATTG TGGAAGAGAG ATCCCATTAT TGGATATACA TCATTACAGC ACTATTTACG AAAAAAAAAA AATGTGGTAC GTCCTTTGCA GCAACATGGA AAATACCACA TGTTCTCATT ACAGAGGCCA GAAATAATGC TGAACACTGA TGGAGAAAGG ACTCCCTATT CCATAATGGT GGGCCCC17C

ACTATAAAAA

CAAGACACCA

AACAGATAGT

TTTGCAAACT

AAAAAAATGA

ATCCAACAAC

AGATACCATC

TGTGGAGAAA

TGTGGTGAT-r

CCAAAAGGAA

ATAGCAAAGA

ATATACATCA

TGTAGTTGGA

TATAAGTGAC

CTrACATCAT ATACAAAAAA CCCTGGAAGA TAGCCTGGGA AAAGCAATAG CAACAAAAAC TTATCTGTAC AACAAAATAA ATGCATCTGA CAAAGGTCTA CCTCATTAAA AAGTGGGCAA CATATGAAAA GATGTTTAAC TAATACCAGT AGGAATGACT AGGGAATGTT TATGCACTGC CCTCAAAGAA TGTAAAACCG TAGAAATTGT TUTACCGTAA CATGGAATCG TCTAAATGCC CAGAATAGTA TGCAGCCATA GGCCATTATC CTAAGCAAAT AGCTAAATAT TGAGTACACA GTGGGAGGAG GGTGAGGATC TGCACACCAA ACCCCTGTGA AGTTAATGGT GGGGGGGTGG ATTTACCTCA TTAGAGTAAT CTCACAATGA TCTTTAATCT GATTAAATGC ATGGGGCATG GTTTTGTAGG CTTrG'rrlTr

CACACAATT

GGTTAAGCTA

TAACATTTAT

CATAACAACC

CCAT'FrGACT

TCCACATTAT

AGCAAATATT

TCTTCTGAAG

TGTAGTTCCA

GCTTTTTrCTT GGACATI=r

TTTGATTTAA

ACCTATATAG

CTTTGTGGTA

TAAGCAAAGA

GTCCAT[FGTA

AGAAACTGGA

AGCATGGCCT

TATTTFAAATA

CCAAATAACT

CTGCAAAGGT

TTCCTCAGAC

TCCAAATGAA

AAATCATTAA

ATAGACATGG GACCTACTTrG AGAATAGAGG TGTGCTTATT ACCTGGGTGA TGAAATAATT AAAACCTGTG CATGTACCCC TGAACCTAAA TAAATCTGAG CATTCATATT AAAATAAAAT GCCAAGTACC TTACACACAT GATGTTTAAT TGTACATATG TGGAAATTGA GCCT7GGAGA AGCATCAGGA TYITAAACTCA GTTCTGAATG GCCATGAAGA ACAGGTCCTT TTCAAGATAT GCTGTTAAAT CYITATTCAAT GCTTAG11TGA AAGTCTTATG GAAAGATTCA CCGCTGAAAG ATAATITFA AACCGTGTAT TCATTTTATA AAATAAATTT TCAGATATTA TCTGGTGTTT GTCTTGTTTFG TTTTACTCAA AAATTTGAGT GAAATTTTAT GGAGTAGTTC CTGTAATTTT TTTTCCTCAT AAATAAAAAC CTTGTTTTA TGATAAAATC AATGTTATTA CCTGAAAY!TC TACCATCCAG GCTI7AAAGAT TTGATATATA GACACACACA CATATATACA TATATATCAT TGTATATAAA GTTTAATA AAAACTAGGA GA11TAATGCC CTTrGAATGA C11'TAACATC TTGCCTAC TTTATAACAT TrATCACAGC AGTCATGAGA GTTAGTAAGC TAATAGCTAA GTGCATGAAC TCTGGAGCTA GCCTCCCTGG ACTGACCAGC TGAGCAATAC TAGGTAAATT GCTCTTGTTC CTTAGTTTCT AAAATAATAT CCACCTCATA GGA'FJ7GGTGT GAGCATTAAA TGAGCATACG AATGCCTTCA CATACTGAAC ACAAATATAC GAGCTGTTGT CTTATTGGGC AGCCGCATGC ATGCAAGGAC CATGTTGGTI' TTGTTCCACA TTGCATCCCC TTCAATAGTT GTTrGACTAT-r ATTACTAGTG GCATTTAACA AATATCTGTT ATJ7TACTGCA AGTGTGTCTA ATATTGATGG CATAATGGGG GAAACTCAAA TAAAACCTTA TTCCCTCATC CTCAGTTATT GACGTTTr TIT1GGCAGG T-rGAACTTT CTGAATTTCC AGCTTCGCAT ATATAAAATA GAGATAGTGA ATTTGAGACA ATTGTGTAAG TTTATCAATA AATAGTAGCT AT1TTGTAT CCTAAACTrrC

AAATAAATAC

TAATGATTTA

ATTTTAATCC

TCATCTGTAA

TATGTAGGCC

TCATGTFTTT

AACCTGGTAT

AAATGAGTGA

CTCTGGAGTC

TGTGTGTGTG

TTCATTCTTG

AAGTATTACA

GTTTAAGTGA

ACAGTATGGA

TCAAT=rTA

TTGGACATCA

TATCAAGTGG

TTTAAAAT

AGATAATAGT

TTTGTATAAA

AATGTGTATG

CATGGTCATTr

CAGATCTGTC

AATAGAGATA

ACTTAACAAC

CCTACCACTA

ACAGTGTGCA

AGAAATACCC

AAACAGGTTT

GGACAACTTA

CAATGTATGG

TATAATATCC

AGGCCACTGC TTTGCATAAC CCAAAAGGGG CACCATTCAT GCAGAATACA ACATAAATGG GCAGTGCAGT ATAGGAACCC TGAGGGGACC TACAGTATAC TTTATAGTTC ATAGATTACA TTATCAGAGT CTCTCAAGGT TGGATGTATT TGAGGTCCAT AAGAGCAATT TAGGATTAAC GAAACCATCT GCAGTGATAT TCTCATrTTA AATCCGCGGG AAAGAAGACA GCTATAAACT GTTTAAGCAT TTTAAATGCC AAGTTCACCA TTTTCTAAAA CACAACAAAT ACCCAGTGAG GGGAAGTAAA TGCCTCTGAA TAAGCAAGTT AATGTCAGTA GTTGTACTGT ATGCATATTG GAGGAACCAA TGTCCAATCA GATGAGCAGG ATATTTGGCA ATAACAAGTT GCCTTTGAGG TTCTrGGCAA GTTCTTTATC AGCATTACAA AGCTAAAAGC TACGCTTATC ATCACTTATA CTGTTGTGCA AATGCTGTCT GTGTTTGCAT CTGCTATTGT TGATGCCTGG TGCATGAATC CCCACAAGTT TTCCCAGAAC TYT-FrATGG CCATCATCTT TAAGTGTCTG GTGAACAGTC ACACAAAAGG GTCAACCTGG GGGATGGCTA GGGTTTGACT CAGTCGTTAC ATTJTCAATAG GGAAATGGTG GCCTGTAACC TCAGGGAATT TTGCCAGTTrG GTCCACCCCA CTCTCTCTCT GGAAGTGGCA CAGCCTAGAA CAGGACCACA GGTGAGAGAA ATGCAAACCC TAACCAGAGA TTGCCAGTAG TAATAGYJ7CA GGACCACCAC CAGCTTrTAT TAAAATTTTT AATAACACTC AGAAAGAAAT AATCTTGGGT TAACTATAAC TAGAATATTG ACTCTTCCTC TGTGGAAGAA

TGTCCCTGGA

AATTATCCCT

AGTAGCTGCA

TGGGACCTGG

AGAGGGAGAA

ATGAACAATA

AAAAATGATT

CTAGCATACC

AGGACTCCAG

ATAGTTTGGT

AGCAGGAAGG

CCTGCTCTGA

AGCAGACTCT

AAGTAT1TGGC

TCAGCCAATC

ATTTAAGCTA

TCAGGGAAGA

CTCACTGAAA

AATAAGTAAA

ATCTTAATTT

TGACTGATT

TGTGATCATT

CCCAGCACTT

GTGAAACCCC

ACATTTGTT[

GATGTAAATA

ATTGTGTAGG

CTGCAGGGTT

AATGTTrTGT

AATTCTAACA

TJTCAGGAGTT

ACTATAATCA

TGGGAGGCCA

GTCTGTACTA

GGGAGGCTGA

GCAATCCAAC

CAGAGGGGTA

GAGATGCCAG

GACACAGCTG

TAAGGGAAAT

TGCAATATTG

TTTCTAATGT

GCTTCTATAT

ACTATITC

GGCAAACAAT

TTTAATTAAG

TCCAGATT-rT T-rATCTrCTT cTfCCTTrATG TGCTTT-rTTA

ATATTTCTAT

YflTTTAAATT

Y'TGTGGAATG

AGCTATGTGA

TAATTTACCT

TTTATTGACA

GCTAATAGTT

TGAATATATT

ATAATITAATTr

AATGAAGCAA

TIrAAAACTGC CGAA1TITAGA

GCCTTCAGTC

AGTCCAAACC

TGGAAAAGTC

TCAGAAGACA

TGAGGACTTC

GCACACTACT

ATTACCATA

TTACATGTA

ACATCAGTTC

ACTTCCTJ7TA

GTTTCAGGGA

TAGATCCACA

ATfAGTATGT

TGTATTGTGC

AATCATCTGG

CACAGAGAGC

AGGCAGGCGC

CCCTGAAGAA

GCCTGTAATG

AGAATJTCTGA

CTGATACTCG

TITACACTT

ACAAGCTGTG

TAGAAGGGTC

TGTAGAATTT

GAAAAATACA

CTAGGCTAAT

AGAAAATATA

TTCTATTATC

A1TTGCAAGG

AGCAGTTTTC

ATACACAATA

TAGGCTGGCA

CTGATGTTGC

TACATATTGG

GAGCTGAAAT

ACTGTAATGA

CATAAATAGG

AGGAGTTAGG

GGAAGATGTG

GGGTGGCTCA

AGACCATCCT

AGCAAGACAA

AACTATTTTT

GATCTrGCAG

AGGCTGATGG

T[AGGTTTTG

TATCTGGCCA

TGTGACAGGT

CGCCTGTAAT

GGCTAACACG ATCAAGAGGT CAGGAGATGG AAAATACAAA AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GCCTGTAGTC CCAGCTACTT GGCAGGAGAA TGGCGTGAAC CCGGGAGGTG GAGCTTGCAG TGAGCCGAGA TCGCATCACT CTOGGCGACA GAGGGAGACT CAGTCTCAAA AAAAAAAAAA AAAAAAAGTC ATGTTAGATC GCAACTGGGG CTGGGCTGTC TGATGCATrT

CAAACGATTC

CCCCTCTTCT

AGGTGGTTAT

AAATTCCACT

TITGGTTGCTA

CTTCTTGCCG

CCTTGGCAAC

TTATTCTTAA

GTCTAFFTAT

TGATCTTCTC

GTTTATTCTT

GGATAAGCAT

TGTCTAATT[

GACAAATAAA

GCTAAATTTA

CTTTTGAACT

TTTTATrATT

TTTGCTTCAT

GAGTAAAGTA

GTTCTAGGTG

CCACTTTACA

AGATACAAAI

TAAATAAAAT

AATCTTTGAT

CACCCACCTT

CTAAACAAAA

CATACAAGT-r

GGTTTTCTFFA

TAAAGCATGG

ACTAGATACT

YITATACCAGT

TfATACAACT

TCATGGCCAA

CCCATTAAAT

GGCTTIGCTGA

ATGGTTTCTC

CATATTGCAG

TACAGTATTA

AI17TTTATCT

TAATTTTTG

TGTTTTCTTA

ACCACTT11TC TITATTCCTrFG

TCAATTTTTC

TAAAACTACA

CTATTCAAYI7 AAYI7GTGTAT

GCTTATTAAT

TATGAGTTAT

AACTTATAAC

AGTCTATIAT

CACATATGTC

CTATTATATG

CATGAGGAGC

AGTCAACTCA

CATTGjTCAGT

ATGATGTTTC

AAGTTTTTTC

T-FCTCTAATC

AAATAAACCT

TGTTTAAGAT

GGTTTAAA

GGGAATTTGT

ATTAAAAAAA

TTTFT-rCCTC TYTCTATTrAA

TCTAACTTCT

AATITTTCCTT

AGAATACTTT

ATTTATTGTG

GTATGCATTA

TFFAAATATTT

AAGTAGAACA

ATGGTCTACT

TATGAAATCA

TTGTCATGT-r

CTGAGGGTTA

GTCAACTCAG TCAACTCTGC TCCCCCACAG CAGCATCATT GAAUTACTCC TGATTATAGA TTGCAATGTT TGGAAGGTAC TCC1TITAG T'FfCCATTf AAAAATCGTG AA'TCCTTrT TGTfAATATG GTGATTTAAT GGTTAGAAAT AAACTGAGCA TGAGGCTATA TTTTATTTF TTGTTCACAT ATATTTGTGA ATGGGATTGG TTAAGGATAT TTTAGACTTA TGAAATATTT TTTGGCTATT TTGAGTATTA CCCAATATAT YITACCTACTC TAGAGATATT CTTTATGTAC GATGAGTGTC ATAGATGT-rC ATCTATITTT CTTCTGAAGT TTAUrATTT CTTTTTTCCA TAAGTTGGGT GTTTAATFT TAGCTTGCTT GTTATTCTTT TGCTGCACCC CAAATTGTTG AAAGTT[CTT TTTGGTTrT AAAAACTAAC CACAGCATAT GGCT-rTGAAA TATATGTACA TCTCACATAC TTATCATT TTGTGGTGAG TTAAATTAT[r AAGCATATTG GGATTTTAAG GTTAACCTGT ATGATTCTAC ATCATTGAAA TTTG'FrCATG TTACATCTGT AGTAGAATTG AGTGTAATCC AGAGAAAAAG AGAAATTTAC TAATCCTCAC CACAATTGTA TGAGGCAGCC AAAAAAAAGC TAGCTCTACT ATTTGTAAAG ACTAGATATT TAAGCATTTT AATTCAAGCT ACAGACATAC CTTCCTAATG AGCTGGGGTT ATGTGGAGGC ACATAGTGAG TTGGTCCCCA CACATACATG TATGAACACC CCAGCCTCCA ACAGAGACAC AGCCCATCCT CAGGAAAACC GTTrCAGTAG TGTGGTCTAT AAGGGAGGCC GAAGGCCCAC ATATCCTATA GTGCTCCAAT TTCTATAT[G GCTTCAGAGT CCACACTGAA CTCTTrACTA AATCACCTT TGGGACACCC YTGTGCATAC CTGGAAGCAA GCTTGGGACG ATrCTGTGAA CTTCTCCCAC AGTAGAAAGG GTGCTGGAGG GTCCTGAGTA GGGGCCACTC TTGCCCAAGT CTAAGAAGGG AGAACCCAGA TACAAGCACA GGTCTTCTGA AATTAATAAT AGCTGTCATT TATIAGTGC TTA11TA'TrTG CCAGTCACTG GCCATATAAC TGCCATATGA GGGATGTACC CTCATGTCA

AGGGTCAGAG

TACTAGAATA

AATAATAACT

TTCTAAATTC

CCATTTTACC

GATGAGAAAA CTGGCATAAA ACGTTTAAGT AACTTGTCCA AGTTACAGAG CTTAGTGAAG CCACAATGTT GCTCAATTTG CTCTCAAACT TCAAAGGGAT GGGAAGGACA CCTAAGTCAT AGAGTCTTTA AGAATCAGAG CTAGAAGGAA TCTTAGATGT TATCTAGTCA GCCTCCTCCC ATTACAGTCC AAGAGAAGAT GGCCCTGAGT TACTTGTAGC TATTTGCA TGTGAATTGC AAGTGAATAT ACAT-rCTACT GAAGATAAAA GATATITrAAA GATATCGCTG GATATAGGAA CAGTGGTTT-F AAATCTCTAG GCTTTAACTT TJ7CTCAGAAC AAGAAATCCT TTTTGGT17T AATCTATATG CACATCTGTA TFITrCTCAA TTATCGGGTA GTAAAATATA AC1TT-rC TGTAATATTT TTTAACTTTA ATGAGTGTTC CTCATAATAG AAAAGTTTGG

TACTTTCTAA

GCAAGTCTGT

TCAAAGGCGA

GCGTTAGGGT

CTGATTCAAA

CTTTGTGAAT

TCATGCAGAG

GTCATATTTA

ACCCCCCCCC

TGGCCCCACC

CCACTCCTAA

GTTTTCCCAG

CCCAGGTCTC

GACTCTCCTC

GCCAAGTGAT

CACAGCCTTA

GAACTCTGCC

AATTGGTTrAA

GTCATTGAAC

GAGACATAGC

CTI-17GGACT

TCTCTATGGC

TCTATAGACA

AAAATGAGGA

CATCTCTCTA

TJTCTCAGAGA

ATAT1TTTGTC CCT-fCACCTT

ACAGAGGTTA

GCTTCTGCCA

ACTTTCATTA

TAAGTT-TCT

GTAGGGTCAC

GCCTACTAAG

ATTAGAGATA

CAAAGTCCTG

TCTGCCCAGC

T7CTGGTTTC

CTCAACCAAG

AGTGTTAAAA

T'FATTGTCAG

AGGGATAGTA ATTTCTCTAG AATATrCATT GCATCATCAA CTATACATTC TGCCTGTTTA GCCAGTGGA GAGGCATTTT TGGAGACTTC CTTGGTCAAA ACTGCATTTC TGAAACTAAA TCTACATflT TAAAAGCCTT AGATGTGGGG CCACAGGCAA YTrGGCCACA TCCTTGACTC GAAATATAAC AAAGGAGGGA CTTTCCTACA GCCAGAACTG TrTGTTTTATA TTTTCCTTTC TCCCTGACCC CAACTAGTCA GAGACCAAAG CTCATCATCA CGCCTGAATA AUTACATTCA ACCCTCTGAC ACCTTAATCT TCCCAGAATA AAACTAGAGT ACAAACTTTA TAAGCTT-TAG TGCCAAGGCA GTATAACCTG TCCAACATCT CTGG1TTTCTA ATfAAACCTG ATCTAGGATC CTCTTCCTCC TCTGAGCCGC AGCATCTCTG GCTTGCAG'rr CAGGGTGTTr ACCYJ7CCCTC CTITATGTGTC CATAGCCCCT GGTAGTATGT TTGAAGACAA CTGTCCCATG CCTTAAGCCT AACTATTG ATCTATTTTC TTCCTGACAT TTAUTCTCTC AAAATTGCTT TCAAGAGTGA ACCCACTTCA GCAAGAGTGT TTGAAACCAA ATTAGACACA CAGCTCTTTT AAACTACC'r7 CTGTCTAGCT ATATGAACTT AGACAAACTA CAATACCATC TATGGCCGGG GATTAAATGC AAATCCAGAT AAAATGAATT AAAAATACTG GCTTAA'Tr CATGCTCACC ATAGCACCGA CCAATT~rTGC CUFTTATGGC TATTTCTTCA AAACTCCTCC YITCAAAGCAA CCTAAATACA GTGTGATGCA GAGGAGGAGT CATGCTGTTT CCCCTACCCC TCCCGCCACA GAGCTCTTCA CCT-rCTCTCT TTTTTTTTf CYUCTCATGT C TAACACAGAG TGCCTTAATT ACATATTACT ACCTGCTATA TTAGAGGCTT ATCAAAAAAA ATAACTGGAT GCCAAGATAA GT'17AACCTA GGTACTTATT CTGTCACCCA GACTGCAGTG AGYI'CATGCA ATCCTTCTGC TTCAGCTCCC TACTTT1TAAA AAAATAATTA GGGATGGGGT AAGCAATCCT CCTGCC1T[ ACCTCCCTAA ATTTAAAAAC UTTTAAAAGA AATCACATTA CAAT17GGTAT TGAAAACACC ACTACCAGAT ACCTCTGAGC CCAAGCCTGC AGGTATACAC

TAATGCTCCA

CTCCAAATCC

CTGGTACATT

CTCAGATTGC

CTT~rCCTAT

TCTCTTATAT

AGATC1TTGA

TGAATACT

CCTTCACAAT

CTGACTGGTC

CCATTGTGAT

AAACCATTGC TATGGGTATA GAAGTAATTA GCACAATTGT ACATGAAACT GATTATACAG GAGACAGGGT CGGCCAGTCT TTTCTTTTAA GGGGTCAGAA TCCCAGTCTC CGCTAT-fGGT TAAGAATTAA ACAGCTAAGT AAAATGGAAC ATTTGCATAA GTTACACCTC CTCCCAGCCA GGTTTACACT TGAACCTTCC TCCCCTGCT7 CCGTTTATCT CCTGTTCCAC TCTTGCTCAA AGTTGAAAGC CACTCTATCT CTTrTTCATC

CTAACTTCAA

TAATr-rGCC

AGCTTGCACA

CCCTFCCAGA

CTrGCAGTCG

TACCTTTGTC

TCTGAATTCT

CTTAGCATAG

TGCTGGATCC

TACATUFTTCA

TAAACATGCC

TCCGAGGATG

AATTGAGAAC

AGTAATrTTTT CTCTT1TGC

A.GGGGTCAGT

TTTrTGTTGTG

ATCTATTCTA

TTAGATACTA

GTTGCCCT-T

CCATAGCACA

CCAGGGATAG

GCAAATGTTT

TGTGTCC1TTT

CTGAAATCAA

TGGCTGCCTA

TATTCCCTUT

A'17CAGTAAC

CTTAAAATTT

TGTCAGGTAC

GTTCTCAAAA

TTCTACCAAA

AGAAGCAGCC

GTGGGATGTT

AGGCCAGGCT

TCG1TATCTA TFIAAACAGAC ATATCTCTGA GCTTCAGTTT TATGAGGAAT GTAAACCAGA GCCGCAAACC CTCTCTAAGA TTT'TC'ITCTA AATATrTGT TATCCACTTT CCCAAACTAA GGTCTGGGTT TGTATITCCTA AAATCCATAC TAGTCCCCAG GCTTCTCACA TTTFCTAGTTC TTCTCTCTCT iCTCACGGGA GCAGAGAAAA TTAACTCCTC ATTGTTI'GAG TFTCCTGCCAA GATAGCTTTC TCCTAAAAAG ACAAACTTTA TTA~rATTAT CAGGGATGCA ATAATAGCTC TGAGTAGCTA GGACTACAGG CTTGTTGTAT TGCCCAGGCT TTGPTTGGAGT TACAGGCATG

CACTACGTCT

GGATTTGGAT

TATTATTAIT

ACTGCAGCCT

CATATGCTAC

CGTCTCAAAC

AGCCACAGCA

CTTACTGTTA

CAAGCTTCAA

CCAGATGGCC

AAAAGAACTG AAAATGGCCG GTTCCTGCCT TAACTGATGA CAT-rCCACCA TCCYJ7CCCCT GGCTCAGAAG ACCTTGACTG

TGACCCCCAC

ATAAAACAGC

AYITCAAAAGC

GCCGTAACTC

AAAGATCCAC

GTAAGTGGCC

TTGGCACCAC

AACGTGTTCT

GTTITAATCAC

CGCCTGCCTG

GGGGCAAGCA

TCTCTGGGCT

TGTTCTCAAG

AATACCGCTT

CCATCCCACA

ATTCTTI7TAC

CCTCCTGCCT

CCATCTGACC

CCAATTCTTC

CAGCTTACAG

GGAGCTAAAG

AGGGATTAAC

CCCTGCCCAC

CTCACCCCTA

17TATTGCTC

AGATCGGGGA

CTATGACCTC

TCTT-TTACT

GCTTCAATCT

ATCTGTGAAC

TGCAGGGATG

GATCCTF7CAC

CCACCTCTCC

TGCCTCCTTC

AACYrAAAAC

GACCCCAATA

AGATCTAAAT

ACGTCGGTCC

GTCCCCTCAG

TCTCCCCTCT

CTCAGCGTCC

TT17CATTCTG

CTTGTGAAAT

AAGTGAAAAA

TCTCCCTI'CG

ACACAAAGCC

ACCTCCCTI'G

TGGTCCTCAG

CTCTTCTCCA

CTCCCYJ7CCC

CCAAAACTCC

CCTGCCTGAT

CTTAGTGGCA

TGGGGGGCAA

ACTATGGGCC

CTCT7CAACT

CAAACTCAAC

AATTCTTGTC4

CTCCCTAGTC

TCCCAACCCC

TCCCCAGACT

GCTCCTCCAC

TGACTAGCCC

CCCCCTTGA

CTGACTCTCT

TGTTTGGTGG

GGAGATCAGT

ACCAACCAGC

GCCTCTCTCA

TrAATTrTCAG

AGCACTGGTC

TATTCACCCA

AGTACCACTF

GTACCCCCCA

ACCITCCACC

CACGTCTGAC

AATGGTICCA

GTAAAATGGA

TCTGTTCCCA

AAGTGTCGCT

GCTCCTCCTC

CCTATAATCC

TCCCCCACCT

CTGTAATrTTT

TTTCAGACTC

TCTCTTCACA

CCCCTGTCAT

CCAAGGAACA

CTATCCCTCA

TTCCTTF7CTT ATGGAC17GG CATTTfCAGAG

TGCCTGGGTG

ACCCCYI'CTC

CTCCATTCCT

CTAAAACCTA

AATAGCCTGA

CAAATGGTCT

ATGCAACTCA

GAGTCTrTCC kGGTCGCTCC

TTCTATCACC

GCCCAACAAT

TATCCAACCT

TCATCATTAT GGTTACTACC ACCAAGATGT CAAGTAAATA IGAAGCAAGT GAAGAATCAC 'ITGTGATTTG TITCCTGCCCC CTCCCCGACT GAGTACCTTG CCACTACCCA CCCAAATCCT AACCTGCCTG CACCTAGGTG CAGACCATGT GACATT-rGOT CCTGCTCTTT GCTCCATGAG TCTCACCAAT TTTAAATTGG ACATCTITTCT CCTTTCAATC TCTGGTAG AGACAGAGGA AAAGACAGTC TTCCCITGAT CTGTCTGATC ACTGCAGGGA GCAAGCACCA CCTCTCCTGG TCCATGTCTC CACCCTCTCT CCCTITTCTC CCT-rAGCCTG AATGCCYUAC T-TCTTCTGC AAACGGCACT TTCAATTTCT GAGGTGCCTG ACATCTGGGC TCCCAAATCC TCCTTCTT-rC AATCFITCCU- TTCTACTGAC CCGCCAGGCT GAATCAGGCT TCCCCTCCTC ACACCTGGTC T-rCCTCTTrAA AGAGGTGGCT CTCCCATCTC AGTTAGTAT-r GCATAGTCAA GGTTAATGCT CC"TTFCTTF TAGGCTTTTT T-rCATCAAAT ATGAATACCT AGCCCACTCC ATGGCTCATT TGGCAGCAAC TCCTAGACAT 'TTACAGCCT TGGACCCAGA GOGGCCAGAA GGTCATCTTA TITCTCAATAT GCATTrTATT ACCCAATCCA CTCCCAACAT TAGAAAAAGC CTTGCCTTCA AAGCGTACAA TrGCCTCCAC TGTGAGAGAA GTGGTCAAGC ATTCCTACAG GCCAAGGAAT GCCCTCAGCC CGGACTGTCC AACTTGCCCA CTCCT-rCCCA GATCTTCTTG ACCATCACAG ATGCTT17GG GCTACCCACT CCACATTACC ATGGCCAGGC TTCTAAACCC CT-rCTTT-rTA GTTATCCCCA TCCCTGACTA TTCCTGGACT CTTGCCACT TCCTCTCATA AACAAATCAC ACCCTCATTA ATCCCACAAC AGGCTTTAAA CTGTAAACTC TCCTI'ACAAT GGATCTGTGC CTITATCAACC TCCTCAATAC CTCCCTCCAA TACTATTCAT TTGCACCCYJ7 CCTCAGCAAC TTACCTGGGC AATT-FCTTFCT TCATCCATTA CATGTCCAGC TAATCTCCCC CTAAAGTACC TCYITGGTCTG AGGCCACCGT GGTCATTTCT GTCTGATAAT GOACAAGCCT AACCTTCATA CCCCTJTACCG ACCTCACCAA GCTCAGCCTC TCGGGCCTGT CCTCGAAATG GGCCCCAGTC TCATTCCAGA TCTGTCTAGT CATACTCCTA ATTTATACT[ TUCCTCCAAA CTCTCTTAAA GTGGATAGAA ATI7CTTTACT TTTATATTCA TCTCCACCAC ACTATCAATC TGGCTTTACA ATrrCTCTT'r CTGCATAT TTAAATGAAG AAAACTCAAG GATAGAGCCA TAAU-AGATG TCCTGGGTTC CCT'TGTGTCT TCCAYTTAGT GACAAATGT[ TTAAGGGAGG AGTAAAAATG AAAAGGCAGA TAAGATCAAC CCCTGACCTA AAAATCCCTG TCTTGTTCTG CTCCCCCTGC TTGCTCAATC GAAAAGGAAT TGTTCACTCG AAGCCCT-FCC TTCTTTAACT ACAACCCCAT AATATCACCC CGCCACCCCT AATCCTGCTC AArIJCACT GCCCCAACAC GTCAGGCCTC TGAGCCCAAG AAGTGAAAAT GGCTGGY-rCC GACTGAGGGA T-rAACCTTGT CCCACCCCTA CCCACAAGTG ACAGCCCCAC CCCATCTCCC AAGCTFCATT GCTCACACAA

TCCAAAAGTT

TAATAGAGTA

ACCCCAGCCA

GACCTCCTCC

TGGGATTCCT

GCACCCACTC

GCTTAGTGGC

TAACTCTTAC

T-FCTC'FrCAA

CTTAAAACTC

CCTGCCCAGT

ACAGCCACAT

rcCCCCTAcC

CTATCCCATT

AGACTCCGGC CCTCAAACCC CACAACAGGA CTTAATTAAC GAGGCAGCCA AGTAGCAACA TATTTCTGAG T-rGCAATTCC

CATCTCCAGT

ATCAGGATCT

CCTAAGCCAT

CCAGAGCCCC

TGAAGACTGA

AGTGGAGGGT

GGTCCTGTTT

CCCAACTCTG

TCCC1TATTA

CTCATTGCTG

TTAACCCACA

AAAACCTAAT

ACACAAGAAC

TGC1TCAAGT

GTTCCATCTG

TGGAACTCTG

TGCTGCCTGA

AAGTCCGTCC

CCCTfGTCTT

GTGCCGATTT

GGCTGAGACA

CCCTTCTTCC

GGTATGGGAC

CACCC77ACC

CTTGCCTGTT

AAAACTGGAC

GCCATGGTGC

TCTGTTCTGG

TTCACTTGGA

TGGACAGCCC

CATGAAAACA

GACTTTACTC

AGGTAGATGC

TCCTTGGTT

GCAGTTTCTC

TAGAACTGAT

GGGATTAAAG CCTGTTATCA

TCCCCCAT

AAATITGTCTT

AACCCCTCCA

CATCCCAGCC

TGTACTGCCG

CCTATCCAGG

IACCCCAGGA

GGTAGACACT

TCCCTTCTGT

TTACTAGTCA

TCCTCAATCC

CAACTTAAAA

CTACAAGGTA

CACCAGCCCA

T-fCACCAT[FC

CCATCATAAC

GATCTTCAGT

CTCTTATTCT

TCACTCACTC

~CTCCAAAAT

TACCTGTCCA

GCCTATCCAC

TAACCCTTAT

TCTCTTCACT

CAAGGCTTCA

CATAGTrCTr

CTGGCAAATT

YTCACTGGAT

CAGACATAAT

AAGCACGCAA

TTAGGAAAGG

YTCAAAATGC

GCCAGAAATC

TGTGGGACCC

GCCCAAGGCT

TCGCCTCAGA

CCT-fCTTAAT

CATAAATGTT

AAACAACATT

TTTAACCAA

CAACCCAAAA

ACCTCTACTC

TGGGTCAACG

ACAACATGTC

ATGCCTUACA

CAAACCCATA

ATCTCAAAAC

CTGACCCTGA

CCATTACCTC

CACGTGCTCT

ACATGCCCCA

CMTCCCACA

GGCCTTCCCA

AGGCTCTTGG

TAATGGTCTT

CCACTTGCCA

ATGGACGCTC

ACTTGTCATC

TGCCCFTTT

TCAAACCGCC

TTTCACCCTA

TCTCTACCTC

CTrCTTTAAC

CTAAGCCACA

TGGCCACTGG

CACTGGAAAT

CTCTGACTGA

AGCCTCCTGG

CAATGCAGAG

GTGGGTATTG

CTTTTATACA

ATTATTTGCT

GTGGCAACTC

CCTCCCTGGC

CCAGTATCCC

CTTTTAAAGC

GGTT7AGTTCA

TACTCTCCTA

ATGCT[CTT

CACCCATCAG

AGTCAACCCA

CCCTGCTGAT

AATCAGGACA

GGGCCTAAGA

CCTCTATACA

TATTCAGTGA

TTAAAAACAC

TTCTCAGAAT

CTITFATTA

CCTACAATCT

TACAGTGCTG

ACCCTTAAGT

ATAAAGCCCT

TCCCCAGCTA

AAACAA'ITGC

AGGACTGGAC AGTACTTTTA CAGCCCAT1T

ACTTGAACTG

TCAACTACTT

TGATATCTCC

GACAAGGTAC

TGTTCCCAT'

TCTCCTAGCC

CACCGAGTCC

AAGATTrCTGT

TGCCCCAAAA

GTAAATGjCCC

TGGTTTTACC

ACTCCAATAC

CTTATGCCAC

AT'TTCTAATC

TCAATTTACT CACTGCTAAA AAAGGGGACT AGTGTTGTT-] TTACCTAAAT CAATCTGGCC TGGTATATGA CAACATAAAA AAAACCTTGC CAACCAAGCA AGTAATTATG CTGAACCCCC TGGGCACTC TCCCGATTCT TAATCCTTTA ATACCTGTTT 'FrCTCCT-FCT CTTATGCAGA TTCTCAATTFC ATACAAAACC GTATCCAGGC CATCACCAAT CATTCTATAC AGACCACCCC TCATATTGTG TTATGCCCAA TT1TCTGCCTC CAAAGAAAGA AATGAAATCC ACAGGCAGAC AGCCTGATGC CACACCCTGG GCCTGGTGGT

ATCAGTTATG

TTCCTCTAAT

AGTCATGACC

TTATCTATAG

TACCAGTACA

CTCTCACGCA

ATTACAGACA

CGCAGCCCCT

GACCCCCTTA

T-TGTATGGAA

AGTCATGTAC

GAGTTGTAAG

AAGCACTGTG

CCCCTGCTTG

CCCTrAAGAG ACTTTTAACT AAAACCCTT CTGGATCAGA CAAGGCCACA TCC1TTGTCA TAAATGGTGG AGGACATTTFG AACAGAAGGG AAAGAACTGT ACAGAGAAGT AATACATTTA TTCATFTCC TAAATCATTA GAGCTCAAGC CTATGCCCAG CTAATTT TACAGCCCAG GCACATlGAT TGACAATTTC ATGAACT-rGG TCATGTGACA AAGATAATGG CAGGGTCACA TCACGGAGAC GAGAGCTCGG TTITIIGAGAC ATGAGTCTTG CCAATGCTCC CAGCTGAATA CAGTGTCTGA GGGGTTrTTGT CTGTGTCTTG TCCTGCTACA GTTTCATCTA CTTACCACAA AATC'TrCC11 CAGCTTAATC TCTCCCACTC TAGGTTCTCA GAAGCAGCCC TGAGAAACAT CGCCCGTTAT CTCTCCACAC CACCCCCAAA 1TJ7ACCACTA T17CGTITTTA TTTT-rC'rrAT TAATATAAGA AGATAGAAAT CCTGCACGTA TACATCCACA TGGCCTGAAG CAAGTGAAGA ATCACAAAAG TGCCT-TAACT GATGATATTC CACCATFGTG ATrGTTCCT GCGCCACCTT GAAATTCCTT CCCCTGGCTC AGAAGCTCCC CCACTGAGCA CCT7GTGACC AAAAACCCCC T-17GACTGTA ATTCCACT ACCCACCCAA ATCCTATAAA YTrGCTGACT CTATTIGG ACTCAGCCCA CCTGCACCCA GGTGATTCAA AGCCTGTTUG GTGGTCTCTI' CACACCGACA CGCGTGATAA TTATTATATT 2AGAGTCTCG CAGGGAAGGC TGTATATATC TCATAAAATG TrGGGGCCCA AAGGCCAAAG GGAAGTAAAG ATCTCATTAT TTCTCCTAAT AA1T[CCCTG GTAGGCTGTT ATGGTGATGG CAGATTTTCT TTCCATAAAA TGTCCATAAT AAAAATCAAA TTGCTGAAGT TGAAAGAGGG CAATGCAAAG AACTTTGGAG CAACTGGCAG ATGGGAGGAA G1TrAAGGGG AAAAATATAG ATGTCTAAAG ACAGTGCAAT TTGGACAAGA AGCCTCTT-rC TT~GCTTCTTT CTATrCTCAT AATCCTTCTG CCTCAGCTTC CCGACTAGCT AGGACTACAG GTATGTGCTA kAAAATTAGA TrTrAATTTG GTGAACTATT TCTGTAGGAA ACTACAATAA CT-rGGGTGAA CAAATCAGAA GGAATGAATA ATTCTGTG1T CCTGGGACTC TACTCTGAGT AAAGCATAGG AGGAGTTATT TCATAAAATG TGGAGCACAA GATCCCCATT TCATAAATAA ATCTGAAGTT CAGAGAGAGT AACAACTGGC AGAGGCAGGG TTCCCACTGA TGCCTCTGAC TCCCTGTCCC AGGCCCTrCC TCCTCCCGCA AGCAGAAGTG CAGGGGGCAG AGCTGACCCT GTGCAGTGAA ATTGGAACAC AAGTGAAAGA CTTCCTGGCT GCCTTAGGAT AAGAACCAGA AAAAAAAGTC TGTGTTTCAG GTGGGGTAAG CAAGGCAAAT CAAGGTTTCT GGAGAATTTT ATATAGGAAT CCTAGAGCTT AGTGTCCATT TGGGTTCCUT GTCTGTGCAC GTGTGCACTG CAAGATTTAC AGTGTACTAT CT-rTGAGAAA GAAAAGTGTA TATATTGGCC ATGGGACAAG CAGCTGTTGA CATTAGGTGA TATATCAGCA GTGCACTGTA ACTAGATACT CCAGGGATCT AAACATATGA TAATTTCAAA ATGCAAAATT GCATG11TACA TTAGTAAAGG ACTAGTTATA TAGAATCTAG GTAAGTGGAT AT'rcTCCAC CTGTTTTAAC TGTTCTTA CTAATAATAT

ATCTTACACC

ATTCAGTTCA

TTCATTCTTG

ATATTATGAA

GAATATAGAA

GGCCCTGATG

TACACCTCCA

AGGGAGAATC

ATCATTACCA

GAGGTATTTC

TATCTGCCCA

TGCTCTTTCT

GACACAAACT

ATAACAAACT

GGGTAACCTr

AAAGAAGTGG

AAAAGGTCTG

TCTTCCATAT

CGTGATAAAA

TCTAATCTCA GGATAAGGAC ATGAAAGCAT GAAAGGTAAG CAAAGCAGTT TCATACTTAA TTrTATGGGC ATAGGAAGTA TCTTGATTTA TGGGATTACT CTTTATTTTT AAATCTATAT TGTTrAGTGGA ATAAACAT GGGGATGTAC CCTAAACCAC TTTTGCAACA GCTTTTGCTA AAAAATTATT CTCATAATGT CAGCTAGCTr CTGAAAGGGC GGTCATCAGA TGCCATAGAG GA'TfATTG AACATTCATT CTGCCCTGAA GGAGCATGTA AGGCAAACTA GTTAACACTTr TCAGTAAGAA GCCAGGAAGA TGGGGTTGAG GGAGGCCTGA AATCTGAGGG CTGAGTTCCT TCAGAGCTGC ATCTGTTCCA ATTTGAGTGA GGAAAAAAAA GGTACCATCA CAATAACCCT AGTCTCAGGG AGGTTAAGAC ATTATGTAAT TCCTAAGATC ACATCATAAT TACAAGGAGT TTGTCAGGGT TGCCATGTGT ATGAATGTGA TTTGCACATC TAATACAGAA TCTGAGATGT GTGCAAATTT GTATGAAATC TCTATTCTCT CATAAGAATT AAAGAGGGTT TGCTGAAACT TATTGAGTGT CAAGTAATGC ATCTCACTGG GGAGAAAACA AAAAAGCAGG CTTTATTCAA GGAGCTCATC ATGGGTTGGA GATGAAATTr AAAGAATATG GGGGCAGGGG AAAGGAGAGC ATTTCA'FfGT .JACATCAAAG AGATGTCACT TGCAGCTAGC G3AAACATTGA CTATAAGAAA TAGGAATGGG

GAATCAAGGA

ATTTCAGTGA

TCTCATAAAA

GGAAACAGCA AAACCCCCAA ACTAAAAAAC AGCGCAGGCT ATTTCTCTCT TCTCTCCTT-r TGCTTGGCAC TCATGAGATG CTAGGTGTGG AAGTCAGCCA ACTGAAAAAG AGAGGTGGCT GAAGAAGGTG GGGAGGCTGA AGCCAGTTAA ATAGGATGGT CCAAUTCACA GACGGCGAGG CTACAGTGCA AATAGGACTC 1TF-CAACTTG AGCAGGACCC CATTrACTTCA CTGGAGTTrAG AAAGAAAGGA GAGCGTAGAC TTITTGAACT TTCTATAAGA GTGTACCTCC ACAGTATACA GAAGACGACG TGAAATTTGA TCTGCAAGAA AACTGAGTCC ATATTCACAT ATGTATCAAA TTTGCACYJ7C ATFTAGAAGT GTCTGTCATC AAGTACAGCA CTGAATTGAA ACTGAAAACA AGAGTCAAGA AAGAGCAAAG TCAGCCATCT TTATATTCCA CATGAATCCT TTCCCTrTAT GGTCTTATTT GTTTCTCCTC AGAAAAGACA AAAAGCTGAG AGGGGCGAAA TGGAAGCTGA AGGAACTGTTr

ACTTCATGTT

FT-MAGTATT

AAAAGATAAT

TGAGAAGAGG

AAGATGAACA

TGGTGTTAAA

CYJ7TAGTGAT

GTCTCCAGAT

TTTAAT17AA

TGGCACGGAG

TAGCTGGGAA

CCACATTGGC

GATTACAGGC

GGCATGCTTA

GATAAATTAT

TGACGTAGGA GOTOCCACCA CCAAGAAT"fT TCTTTCACCA AAGAGTTTAA AAATTGCAAA AGCAAGGAAA TGCTTTCAGC AATGTAAGCA AACCCTAGTA ATGCAGACTC TGATTCAGTA GCT-rATGCCA CTGGCGCACA CTGTATAAAC ACCTGTGGGC GGTCAGGTAG AAATCTI'CCC CACAAAACGT TTCATGGAAG AGGGCGAT[ AATATGGGTC ACTTGGAGTG TTAGTAGTAA TGGAAATCTC AGACAAGAGG GCAGCACTTC TCAGATTTTrC GGTCTGAGTG GAGCCTGAGA GACCCCAC1T GGAGAAATTT TGGGGGTFIGA GGGATAAATG AGATGCACTG AAGGAAACAC GATTJTAAAGG ATCTCATGAT ATTCATACTG AAAGAAAAAC AGGTAAATAT TCATTAGAGA CCAGGCT'rrA GGAACCTCTG ATGTGCTTAC CACTCAGAGA T7CTGCACCC CTAACAAGCT TI7GTGGTGCA TACGGTCTTT CTAATGAGTC TGAAGGACAG TGTAGATI'GA TTYT-FTAAAT TTATGTTTAT TTTAAT-rTAA TTTATTTAT[ TATTTATTTT TGAGATGGAG TCTCACTCTG TTGCCCAGTC CGGAGTGCAG GCAGCTCATG CAACCACGGC CTCCTGGGTT TACAGGCACG TGCCAGCACA CCCAGCTAAT CAAGCTAATC TCAAACTCCT GACCTCATGA GTGAGCCACC GAGCCCAGCT GTAGATTGAT AATGGAAAGT GAAATTGGAG AAAATTTAAA ATCCTGGGAT ATAAITJTAAT GAGATGGTAA CAAGCGATTC TTCCGCCTCA ACT-rCCTGAG TT1TGTAT

TCCACCTGCC

TTTGAGCAGT

CTCATGAAAT

CACATTflAGT

AGGAGAGAAT

CTCATGATGA

AAATGTTTCT

TGGGTGTAGC

TTAGTAGAGA TGGGGTTTCA ACGGCCTCCG AAAGTGCTGG GGAAAGTCAA GGAATTAGAA AGTGGTGGTT ATAAACTCGT TTAAAGAAAT AAGTGACACT GAAATATGGT ATGTCTTCAC ACTGTCAGGG TAAACCACAG GAAAACAAAA UTTCACATAT TTCTATCCTG CCAGAATTTA YTTTTGTGT GACACAACTG TCTTATTCTT GGAAAGGACA AGCACCTI7TC AAAGGGAGAA CCAGATTCTG TTCAGCAGCT GCAAATGTGC TTGCCAAAAT GCCCTCCTCT GAGGTTGGCA TCATATCTTC GACAGTAGAA ACCAAATGAG GTGATAAACA TGAAACCACA AATGCCCAAG GAGTCATrCA ATGAAAATTC ACCCAAGAAC TTFAAAAAAAA TACCTTGAC TTGTTCTAAA AACACACCAT TrCAGTGTGA AAAAAAAAAC CACGTTACTG

AGGAGCTGGT

AGAGACAAAA

CTGTGTATCT

GAGTCATTf GCAGAAGAGT CAAAATAACC CAGCAAGAAA TTCACCAT17C AAAAGCTAAT AGAAATGAAC ACAAACTACT AAAAAAAGGC TCATGGTGTT TAGTGTGATA GTA'I1TCAT-ITT ACTTCTACCC CACCCTrCCT CAGTGCCGTC ACACAATGGT GAAAAGGAGG GTGCCTGGGA CTTCYCCACTC TAAGiCTGGTA

GTCAAGGGTC

TCAGCATTGC

GATGTTCATA

AACAGTATAC

CAAGGCCTAT

CATATTCAGA

AAATAATTCT

AGCCTTCCTT

GCCCCTGAAA

CTTCCTCC

TTTCTATAAC

TGCCTTGTAT

T-rGAGTTCTA AAAGCATACG CATTTATTGT GACCTCAGGC GACCCTI'CTC CCACAGACTT AACATGGAAT TAATATTTGA AGAAAACTTA CTTAAT7AGT CCTAGAATTrC TGTGATTCTT TCYITGCTAG GCC'FrTCTAG TCCAACTTCA ACTCCACAAC AATGCTTTCA TAGTCTCACT TGCTTTTCTC CATATACCTA CACCAAGCCA AATGACCTTT

CGTTAAGAGC

TATITTAMF

AAAGGCATAT

ATGA17CCTG

CTCTGTGCCT

TTCATGATTT

TAAAGGTA TGATTATTGT TCAACTACAA AAAGAGTTTG ATGAATTAAT ACAGCCTTGG

ACCATCTGGT

TCCTCAATAA

ACCATACCAC

AATCCTATCT

TCCTTCTTAA

GAAGCATTCA

GCCATGGGCT

TGCTTACACA

ATT1CATA

ATATAGCACC

TCTTAACTCC

GAAAGCTTAG

GATCCAAATG

GTTTCTTrAT

AAGACATGTA

AACTAACTCT

AATGTGATAT

TCAATAAATG

AGACTTATGT

CAAGAAAGTrT A1TTTCCTTCC

AGCAACCTTC

CATrGGCCAT

CCAGCTAGGT

CAGTTTCCAA

AGTATGGATC

CAGTAATGAA

AACCATTCAT

GTCACTTGCT

CCACCAAGAT

AGAGCTGGGC

TATTGGGGCC

CTGCTCAGTG

TACAGACTGC

'ITTATAACAT

TACCATGCTC

AATAATT'TC

CACAAAAATG

TTTTCTGATT TT17TCTTT7C TATA17CCTG CTGAAATCAG GGACCAGGCT GACTCCTCTT GCTGTCTCAA

TTCAATAAAC

CTTAGCATGG

TTAAAAAAAA

AAAACAGCTC

ACATCTGTGG

CCATTTGCAC

CTCATCCAGT

GTCTCTACTUT

CAAATAGTCT

AACCGTTCCC

CTGGCAACAT

ACTCTCTCCC

GATGGCAGTUF

TAGGTCCAAT

TTrACCTCCAA

CCAGGTGAGA

TATCACCTCC

CTAATAACTG

ACTGCTCTGC

AACTATTAAT TOACTOATTA TAAAAAATCA GTGAACCATT TAATTAGCTT TfTGCTAATA TTCTTCCAGC CAGTCTCTCC AAAATCTAGT TGATCTGCTrF CCATCTAGTG GCAATTAAAA TGGGTAGAYIT GTGCCAGAAA ATACTCAC TCAGTAGGTG GTTTCCTGCC ACAGACATAG GGAGACCAGC CCAGAGAAAG TAGTAAAGAG AAGACAGAGT AA11TAAAAAG AATAAAAAGA TACCCCTGCC CCACTrCTCC TFCACAGCCA AACATTTTAA TCTCATCCTC AGTAATGCTC AATGCTTGGC CGTCTGACCT CCCCACTGAC ACCCTTGTTG CATCCAGGGG ATACTTACTG CITFrCTTTGT TTCCTTGGCA YITCATTACCC CACACTCTTT CTM~CATTT CTCTTTCCCT TAGGTGACTT ATTAGATAAT AGGTCCTCTT CCATTCTTAA AGCACTCACA CCCTCCCTGG ACCTCCTGAA ATGTGAGGGA CCCAAATCCA CUTCTCCTGC GAGCCACAGT GAATGATGTG CATACACCCA AAGCTCAGTA AACCTCTCAT TCTTTfATGT TCCCTJTCTCA GAAGTAAACA AAACTTAATA TAGCAATTTG TCCTGTGCCT CAAGGACATC CAGGTGGTTC CGGTAGCCAG CGAGTrTGAA AGAAATCTTC AAGCCTTTCC TCACTAGACT ACCTCCACTG ATCGTACATC AAGAGATGAC TGCTJTGTTCT CTGTCU-GAT GTCTGCACTG GTTCTCTTGG CAATGTTTGA CTCCTCTTCC TFCTCCCTGC GATGTTCCTC TGGCTCCCAT ATGATAGTAC CCACTCCTGA CATAGCCTCT GTGCYF-TGGA CAAAACTGAA CCCATGATCT GGACTACCAT CCGCCAGTTT TAACAGACAC ATTCAGTTAA CAGGCGCCAT CGGT11TTAAT CTGTCTCCCA CACTTGCCAT GTTTAAACCC CYFTAGTGAT TTTATGATCT GGCTJTCTGGT TAAGTTTGTG ATTGGTAGGA TCTAGCATTT TAAAGGAAGC GTTTATTTTA CTTAAACTCT TTrTTCCATC TTCATTTCTG TrTCTCCAGT AGAAGAAATT GGTAGAATTC ATGCTCCCTA ATAGTCAATT GAATAAGCAT AAGATGATAA TrTGATTCT-T CTCTCTCACT TTTAGCCAAT CTTACTACTA GTTCCCTAGA TCTTATTTCA

CAAATGCCTC

AGGGTGACCT

TGAACCCATT

ATCCCAAAAG ACCTCAAGAT GCCTCATT TCCCCACTTfT TGGTTGCCCA AACCAGCATC TCAGTTGTCC AGCTGGGTAC CCU-CCTAAA ATTCCAGAGC CCAGGTGGGC CATCAACTTTr TGAGCTTCAA GACCAAACTG CAAAACAAGT CTCTTTGAAT TATAAGATGC CAGAGGTAAG AAAGCCCATA TCACATGGCT T-rCCTTTGCA TTCTAAGCAA

CAATCCCTTC

TGAATATGTC

AAGTCACTAA

CACATGTCTG

AAAAATACTT

GACAATGCCT

GCTTGTTCAA

CCTCAGAAAA

AGAAATCATC

ACCAAAGTCC

ACCCTAGATA

CATCTCCTCC

GCCTCCTTGG

CCAGGCTCAC

GCTACTCACT

TATACATTAG

[GGCCCATAC

TCACTTCATT

TCCTTTCATA

CTGAGAAATA

CACTGTGCTA

GGAAGCTGTA

TCTTTCCCAC ATTTCTGAAG YITATTCATTT CTCAATAAGT CACACCACAA TGTTITTTAAC GTTAGAGCAA TTGAATGCAA TTGAATATTT CTTAAATAAT ATATTTAAGA ACAAGAAGAA AATTCTGAGG TAATCAGAAA AATCTCCCTT TACATAAACT GCccTITCT AATAGGGATT ACTTGTTCGT TCATTCATTC ATTCAGCTCC ACTAGCACCA AAAAGCACAG CTCTGAAAGG AAGCTAGTAG ATTTATCACC TTATCTGGTC ATTTGGATGA GGACCCCAGG TAAATAAACT ACTATGGGGT TAATGTGTCT AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAATGAAT CAGCAGATGT GGAAACTCCT CGCCACTAAT AAAACTTACC T-rCTCTTGGA TTTCTTGCCT GAAAATAGAA AATAGAGAAA AGGCATTAGC AAAAATTAGA CAATTTAAAG TTTTCAAGT AAGGGAGAAG GAAGACTCCC ACTCTCAAAA CTGTCTTUTG AAGTATATTA GGTATTTGTT AGGTGGACCC TATCTGTGTC AAAGGAGATT TGAGGAACTG GCTT7AATAAA CAGTGGTAGA CACTAATACA GAACAGACAT GTTGATGCAG ATGCCTCCTG AGGTFICCATT CCATTCTCCG TGCTACTCAA GAAGACAGAA 25441 TTrGCTAAATT GCCTGGTGGC AAGACCCAAT ATGTCCATTC AAGTGTTTAT CCCYUCCCAA ATACTGTAAA ACTATGTGCC TTGGTCTITGT TGGTAGGAAT GAATATCACA TGGTCTCCT AAGTATATAA AACTTTGTGA CCCTAAGTTT AAATITTGGCT GCGAAGAGCG AAACAACAAA TrTCTTACT TTrTTAATTAA GAAAAAAGCA GAATATAAAT

TCTGCCATCT

ATTACAGCTC

TGTGCAGCCT

TfTGACTGGCT

CATACATTTT

TTCTYTTTTT

CATCCTACCT GCAGATTCTT ACAGCATCAT CTCTATGAGA CATCTGAGTA ACTAATGTGT GTAAGGAAAC TCAGAGCTAG TGTGCCATAA CTTCAACCTT TTFTTFGTA CTCAATAAAA CCCTfGAGGG ACAGCTGCTA ATCCACAAGA GAATFUCACT ITFTATCTTA CAAACACAAG ATCTGAGACC CTCTCCTACC GGTTCCAAAT GATT1TTTGTA CATCAAGCTC ATTTATTATT GCTTCCACAG CGTGGAAGGG TTT-rAATITTG CTATACTGAA AAGTAGATAA CTTAAAAAAA

GCAATATATT

ACCTGTAGTG

GGCATAATAA

AGCACGTAGA

CT-CTAAAAT

ATTCTGGTTA

CTG11TCCTAC

TGGTCTAACC

GAAGACCAGT

GTATTIGA

TGACTAATCA

GTT-[CTGGAA

TCAGTGGCTG TAAAGTGGCA TAGTGTGTAT TITGAACAGCT TTGTATCATC CTCATTGGGT CAGTGTTrGCA TTACTGTTTT TCAGCCTGCT GATGACCAAG GCYI7CACATA AATATTTYT TGAGAGAGTT TCATTTTGAA CTGTGTGTTG GTTCTGGTGG GATTTTAGAA GATGTATCTG GATTrTGGCCT AAAACATCAT GAAAATGATA ATGCCTGGTG

YTCTAGAATC

ACTTTCTTIT

TGATAAAATA

AATCCTTTAA

GACCCGAGTG GGT-rGCCCAA A1TGGCTTCT CACAT-rTTGT ACTGTTCTCA CATCFTT ACTCT-rTGAG CAGAAAGAAT CAT11TGGGAG ATCCTACCCA GGTGAAAGCC CTATTrTGCC CTAAACTACA ATTJTCT[CAT CTGT-rAAAGA AAATATTTCC AAGTATTTAG TTCAGGTCCT AGTATITAAAG ACTACTATTT GAAATCTTTT TGCACTTGAG CAGGGGGAAT CAAATCTGAA T-TAATrCAG TTAGGGATGA TGAACCTAAC AGCAATAGAT GAGTAAGAAT GAAAAAGGAA CTAAGGGGGC ATGTGTTCAG TTTCATGCCC GAAATTCTTC CAACCGAGGA AAAAACCAGT TCACAAATCT GACTGGAGTC TAATCTCTGA CTCTGGGTCC TGCTGATATG TGCCCTGGT-r TCCTTATA CCAAACAGGG CCAATGGTAG CACAAAATGT GTCTAGATGA CTG117CCITA YITCCTTJ7CCT AAAAGAAAGG AGGGAAAGTC GCAGGGGACA AAGTGCTAGA GTCAGAAGAT TCATCTGAGG ACAGAAGAAT CTrCATTGGC TACCATGCTC TAAATAGTTA CCTGTGCCCT YI=CTAACT TAAATTCTCT CTCTCTCTCT CTCTCTCTCT GTGTATATAT ATACATATAC ACACACCTAA ACACACACAT AGAGA'TfAT GACTITrFAC TITATCCT-r TrTGTCTTAG ATTrAGCCTG GGAATGTAGC CATTAIUCT ACCAYITGCCT GCCCATGCAC AAGGACACAT TCCATACTAA GACTACTAGG AGGGGTGAAG GCTCTAGTCA ATTAGAACCC AAAAAGCCTA ACACACACAT AGACACACAC GTAAATGCCA TTAACTATAT CCATAGGAAA AATACTCT-rC

ATGTTTTAAA

AAGATGTTGT

GTGCAGTGGT

TCCTGGGTAG

GGACCAACCT

TTTATAAATG

GCTGTCATGG

CTGGGACTAC

ACAACTAAAA

AAGACTTT-T

C'I1TACTGCAG

ATGTGCATGC

TCTTTGGAAA

'ITTTTTTIrT CC1TGACCTC

TACCATGCCT

GCAGAATCAT TTGTAAGTTG TMrGAGACA GGGCCTCACT CTGGGTTCAA GTGATCCTCC GACTAATTTr TTGTATT

GTGAAAATGG

CTGTTGTGGA

CACCTCAGTC

GTAGAGATGT

GGTTTCGCCA

AAGTGCTGG

AGATACCCTA

ACTAGCCTAA

CGGTTTGAGA

CCTfGCTTAT

GATTCTACAA

AGCCCCAAAG

TGTTGCCCAG GCTGGTCTTG AACTCGTGGG ATTAGAGGTG ACAGCCAAGG TGCCTGGCCC AGCTTCCTAC CAAGCCAGTG ATCTTTTGGG CTGCCCGTTA TCTGTTTCCT GT11TGCCCCA TCTT7GTACAG AAATGACTCC AAGGTAAAAA AAAACAGCCT TAGCCAGCTA ACCCCTCACT ACACTTATTA AAAGATTTTA GAATTCGGAA TCCTTAAAAT TATTTAGACA ATAGCCACCT

CTCAAGTAAT

ACAGATGAAG

GCTTCTG1T

CACTGATTCC

ATTTAAAAAC

ACATGCAAAT

ATAAATAGCT

CCTCCTGCCT CAGCCTCCAA ACTAT11TAAT GTfATCTTAA TCTITGTTGG CATAACTGTA CACAGCAGTT TTCAAGTTAT AACCCCTCTA ATTTTTAC GAGTTTGATr CTATTCTTTr TCCTTAT[AA GGTGACTTAC TATCCCAGGG GGCAGTGTGT AATAACCCAC CCTGUTCTCT ATCCGTCAGT TCTGCCATCA TCGCCCAAGG TAGGAAGAAA GACAGGACAA CCGGGGTCAA GATTGAAGT CTCAATGGAA AGTACTTGAT ACTTATACTT AATCAGCACA GAATT[CTAA GCTAATGAAG TTCTTGCATA AAACTTACCT AGCGCCCACT CTGATAAATA ATATTVITGT GAACAGAATA CGTACTAACT GCAACACAGA GCAGTrGG'Fr TFT1T1T TTGAGACAGA GCAACCTCCG CCTCCCGGGT CCGCCACCAC GCCTGGCTAA CTUGAACTGC TGAGCTCATG AGAATAATCA GTGGTTGGAG AAAACTGTCA TTCTTCTTTr AGTACTGTAT AGTACTfrAGT ACTGTATAAT ACTATAAGAT TAGCAAGGGC AGAGACATTT TAACTGCTCA GTGCTCTCAG TCAACAATCC CCACCCCCCT CACACACT'Ff GTCTTTCTGG ATTCTCAAAT TTAAATGAAA GATAAGATCA GAGTGGCACG AATTGCCAGT GTAAATGGAC AGGGGGCAAC CTrTACATAC

GCCTTAATGC

AGTGAGATTC

GTTATACATA

ATTGGTTAGA

CAATTAGGGA

CATA17CAGT

CACACCTGGC

CTTCCAGGTG

ACTTTAAAGC

CTCAAGGCAG

TrAGAGCTGT

GCCCATGTGT

TGGACATTAG

GAGATAGTGT

CAAAACAGGT

AGTTTGGCCA

TGAGACACAC

TCCTCCT7CT

GGCCTTGGTG

TGGGAACCAG

ACCCACTTCC

GTCATTTTT

AATTTGATGG AAGGAAAATT AAAATGACAA AGCAATJ7GTT TCGAGATCAT CCCTGAACTT GTCTCACTCT GTCACCAGGC TGGAGTGCAA TCAAGTGATT CTTCTGTCTC AGCCTCCCGA TTTTTGTATT TTTAGTAGAG ACAGGGTTTC ATCCGCCCGC CTCGGCCTCC CAAAGTGCTG ATATCTTAAA AGCTGCCCAA TGTCCATGAA AATGTGGCAC CATACACCCA AGGCCTGCTG TCATGCC11TA AGGTAAAGGG AGTGATAATC CTTrTTCCTCT CCAGTGACGG ATGGTTGGAA AATAGATACT TGGGAGAATA CATGGGAATT GTGACTCTTG AAGAGGTCAG GTA1TFTGGGA TAGTGGAATT GTAGCATTGA AATCCAAGGC CAGAATTAAT TAAGAGCAGG CCAGGCGTGG CAGGCAGATC ACGAGGTCAG GAGATCGAGA TCAACTGAGC CCACAGAAAG GAAACAGGTA TATCTTTTTT TGGTGCGGTC TCAGCTCACT GTAGCTGGGA TTACAGGTGC ACCATGTTGG CCAGGCTGGT GGAUTACAGG CATGAGCCAC TGTTACAGCC TTGAATGGTT CAGGCTAGTG GG'FTGCTCAC TGGGCAGCAG ATGTTAACTT AGCATATATG GTGCATTTGG TCTCCCAGGG TTAATGCAAT GCAGTGCCTT GAAACCTTAG ATGTAGGCTC TTAGAGGACA TGGCTCACAC CTGTAATCCA CCACTCTGGC TAACACAGTG GCTCCTGTAG TCCCAGCTAC AGTGAGCTGA AATTGCACCA GTATTAAAGA ATTACATAAG TGCCTTGAAG GTAATAGACA TGAAGGTGTG TCCTGGGCTG CTGCTTGTGT TGAATCTATC TGTGTTCTT-F TCATGTGAAG AGCCGTnTGG GAGGCCAAGG AAACCCCGTG TCTACTAAAA ATACAAAAAA 'r7GGGAGGCT GAGGTGGGAG AATAGCTTGA CTGCACTCTA GCCTGGTGAC AGAGTGAGGC AGCAAAGAAC CATTAGAATA TCTCACTTAG TITAGCTGGGC ATGGTGGCAC ACCCAGAAGG CGGAGGTTGC TCTGTCTCAA AAAAAAAAAA TTGTrATCAG CCTAGCAAGC AATCAGCCAA CCTGTTTTAA AGAATGTAAA GCTI'GGCATC 1TCTrTTTC ACTTTAA-AGT

TFTTTAAAAG

ATTTACATGT

ACA1TTTAATT

TTAAACTCAC

ACCATGACTG

ATTCTGAAAG

ATA1TTTGACT

CTGGCATGGG

CTACAGAATC

AATGGTCATC

AAAAGCCTAA

AATCATTAAT

GCACTAATTT

GTTTJAGAGAT

AAAAAATCTG

CTATCCTTAG

GATTGAGAGA

GGAAATGAAC

GGCCTCCCTG

ATTTCTGACA

GACACAGGTA

TGTCAGGTGG

T-rAGCTTAGT

CATTTCAATG

TTrATCAGAT GAAAAGCGAA CTCCAGGGAC TGATGGCTCT TCCTGTGGGT TTCTTTT ATACCTTTUT TTAATCTCCT TGCCAGCCAA ATGATAAATG CCAACCCAGA GAATGCAGTA CCACTGGAAT GAAGAGGGGG TTATAATCAC CCTCCYJ7AAT CATJTGAGAAA CTT11TGTCCA AGAAATCAGT AAGGCACATA GCATGAGACC ACCAGGATTA 11-TCCTTrAGT CTATCTCATG 1TTTCCTCC U-ACATCTCC CAGTAGTAGC CCA1TFGATG CCATTJ7GACA GATGAGGAAA AAGGCCCCTG ATGAGTCTAC AGCATAGGCA AAGACTGGAC CAGCCTTGCT AGTCTAATGC TCAATGCCCA GATTTGTGGT TCATAGAGTT CCTGAAAATG CACCTAAAAA TGT-rGGCAAG GTTGTATTTA GCTCCATGGA CTTGTTCAAT GACTGGAACT CTGAAACACA GAGAAGAGCT TACAACTTCA GGAAAAATAA AAGCCAATGA TCTGAACTGG ATAATTCACC AGTCAAAGGA GCTTTTACTT TAAAGCAGTT GTGCAAAAAT AAGCACTTGA TTTTTACATG CCAAGGACCT CTTTCCAATG CAGTAGTTAC CACTTCCCTC TACT7CCT-rC ACGAATAAGT AAAAGGGCAT ACTCTTGTAA GTGTAAACTA AGY[rCATTTG GGAGCCTCTA TTTGAAAATA CTGGTATAAA TCTCCTGATA CTAACATYI7G AAGGAATCTA CT1TITTACA TATTGGCAGA GGGTCTGATT TTCTTCCCAT TACT17GATG AACCTTTTCA AGGTGATTTG ATCCCCACAC CCAAATATAT AGGCTCAAGT TCCCAGGAGC TCCAGACAGA AGGTACCTGT TGGCTTGATG AAGATGAGGA ACTAGCTAGG CCTITAAAGGG AAATGTCTCT GATAGGCCTA ATACACAGTC CTCTGCTAAA CCTCTCTCTG CTCATCCACT CTACTCCCTG GCCCTGGGCA CGCAGCACAC AGAGATCAGC GCTTCTGTAG ATCCTACCAT 'FFAAAGACT[ TTGTCATCCA TGCAGATAGT CTCAGGAGCA GCTATI7CTTT CACATGCTAG CTTAACATGC ATGCTTTA GCACCTATTG CCAGGCACTG AGGGTATACA AAGATGAACA AGACATGATT C'FrCTCATAT ACAGATAGAT TTTGGAGGCA GATGATFCAG GAGTATCCAT TA1TFGGGGA AGTAGGTGGT CATTAGTGAC CT1TrTACAGG GGCTAACAGA GATGTTAGAT TGTAGTGGAA TAGAAGAATG GGTAAAAAGT AAATCAGTGA GTTCAGATTT TAGGAGTTAA GATGGCAAGA GGTGAGAACA AAAAAAGGAA ATGATTGTCA TTAAAGGAGG AGGAAAGACC AGCCAAAGAT TTrACAGTGA GTTAAGCATA cAAATTITATT TCTAGGCCAC ATAT-rCYUAG CAAAACAACA TGTAAATGTr TATGTATGTC TTTCCTCATA TCTGCTCATC CATCAGCTCC ATCGTTAAGA T-rTCAG17TT CCAGGACAAA CYUFACTCACT TTGACATATT OGACTAGGAT TTGACCAGAT TCCAGATGAT TCACAAATGG 1T=CTTCTT CCCAATTrAAC TCAGTTCCTr CTGAGCAGAT GAAGGTACAT GCAGAGOTAA AGCTGAAGCT GGCCAGGGGA TGGCTACAGT TCATGATCCC CAAATCTGGT GCTGATAGAG GCTCACACTG AATCACTTCA ATGAAAAAGA AAAAAAAAAA AAAGACAAAA CAGTATCT GAGTAGAGAC CCTCCCTGA GCAAAGGATT TTTAGCCAAA GCTGCCTGAC TACATTACTT GTGATATrGC TTCCAGGCTT TATTTCTTG AGAATGATGG TGGGTGGTGA ATGAGAGATG AAGGCAAGGA AGCATTGAAA GCTGTGGGGA GAGGAGTAGC TACTCCAGGC TGCTGCCCTA GCTAAGGTGA CCCTCCCCTT CTGCTGGAAG TACCATGCCA TATGGCCTCT GCATCAAGGG CTCYFATGGG ATATTCTCAG AGAATCTCTG CCGTTTrCATC TGTTCTGATA TCTACCCAAG CATTTTGAAA AACATCCCAA TTCACTGAAG CAAGTCCAAC TTCCGTAAAT TCCAGTAGGT GGGTTGACAG TTTTATAATT TCAATAAGGG ATTTTGATAG CAC17CTAAG AAUTAAACTA CTTAAACTAA TGCATCAGGA GCATACTTGT AGAAAAGTTA ACCAAAACTT CGTAAGTTCA GATGACATTG GTTTTCTCCC ATATGGAGAT AAGGUTGGCA GTTAAAAATG AAAAAAAAAA AAAAACCTAC CT-rATTrCAA ACUTGAAAAG ATCAAGAGAT TGTG1TTTG T-FTTTCAGTT GTTATTCTCC TAAAAGTTTA TGCATGAGGA AAAGTAAAAG TGATTTTAAG AATAAGCCAA ATAAAACAAC CAAGAAAGAC CTCCACTACC GACACCACAT AAAACAGGTG 17ATTGAGAG GAGAAGAACC 'ITTATGCAAT GGCAATGAGA AAAATAAAAA ACACAGTATA ACACTGGGAG ATGGCUrCAG GGGTATTTGG TTFrTTACTTT TTAGAATAAG TCCITTGAGA AACATCACAG TAGGTTAAAC GACTTCTCAG CAAACTTCTA CTGAATGTTC TGACTGTAAG GAAGTTACTC ACCTTrGACAG GTTGGTTCTG GAGATGACCA AATCCCAGTT AAGTT-rGTTC CTTCAGAGCA GCTGAAGGCA GGGTGAGTAC AGTCCATGGT ACCCAGCTCT GGGGCCTCCA AAGAAACAGT ATGGGGAAGA GTTAAGAGGA ACTGACGCCT ACCATGTGCC TAAACAAG G'FrACTTGAA CCCTCCAACT TGAAATTGTG 11TATCTTTAT CAAATTGATA TGGAAACTAA TTAGAACAAA GCCTGACTCA TCAGAAATTC TAAGTAAACA ATTATCTGTA GTGAGAATCC TTAAAGCCAA ATAGGTGTAA CTATCACATC AGAGCCCCTG AGTCTACTAG AGTAYI'GGGA ATAATAAGCC TTCTTTGCAA GGAGAGAATA TAAAAGTCTA ATI'CTAGCTC AGTTCCAGAA TTTTAACTCT TTTGATTTrTG CCTGTITCTGA TTGGTGGTAC AATAGGTAAA TTTAAGACTT GCCATGCCAT TTAGTAAACA GTACAAC1TT CATGTCTTAT CTACCTTGCT CTAGAGACTT CAAGGAAGAA TGGACTCAAG CTGGGAAGGA AACTGGTTGG TATTAAGTAG AAAATGTAAC TGAGGTTCAA CAAGACATTA ACCATGCTGT ATTGCTATAA GTCATGTTAC TTGTTTGGGA GGTTTT17CAA AAAAATfAG AAAGTTAGGT TAAATTAGGC TCCTAAGTTT CCCAGGATTG CATGACAAAA CCTCTAGTCT GTTTCCAAAT GGTCCACAGG TGGT11TCTTC CACTGTGAGC TGAAGCTGAA OTTTCCCAAA AAGGCTCACA CTGAATCACT TCAATAGGGA rGGATTTGAAT CCTAGCCCTG CCACTTGATA TCAGTTTCTT CATCTATATA AGAGGAATAA ATGTAATTCA ATTAGCATAA GTCAAGGACC TTYAGCTAGTC TTCATATTAT TATCYUrCAGC CTGGGAATGA CCAGCTTAGT CGGGAAATAA GCAAGATGTT CAGAGAAAGA GTGGGTCTCC GGAAGCATTT TGACCTCAAT TCTGTCTTCT ACAACCCTCT CCAGAAACTG TATCTATTTC GGAAATCAAA GTI=CACAT TTTAGACCCT TCCTCATCTG TCAAAYI1TAA GCCATTATTG GAATCAGAAG AATTTTTGTA TTTGGAAACT ATATGAGATG AGATTAGGGA GAAACATGGG AACTAAGAGA AAATGTTATC TJTT17TCATT GTATCTAUTA TATATCAAGC A'17ACTCTGG GGCTTGAAGA GCTTAGATTT CACCCTGTAG TAGGTAGAAA TTAATGGGTG GATTGTCATG TATGTGTGAT GTGTTTTAAT TGCTTY-rAAT

GATTTAAAGA

GACAAAATGG

TGATCAGTCT

CCCTGTAGTA TGAATAATGT ATTTGAGGGG AGCTAAT7TA AAATTGTGGA ACTCATCTAA TAAACTATTG CAAGAATCTA GAAGAAAGAT AATGACGGCA ATGGTAGTAG AGTTGACAAG TGGAAGACAA ATTAGAAAAA CACTAAGTTFG TAAAAATTGG TAGAATGTTA CCCTGCATAA ATGTTGGGGG AGTTAAGAGA GTCTCATACC AGGGTGCCCA TGTAAATGGT GATTCCACAT ACTGAGATAA GAAATACGAA GAGAAAAGCT GACTGGGAAC AATTGGTTTT ATAGTCTTTT AAACATCCCA AAGGACATCC 3TAGCATATT TGAGTTCAGA GCTGGAGATA GGCTTATCAG TCCAAAGATC ACATAGATTT GTGAGTCCGC AAAAGTCAGT AAGTTTGACC AAAGGATACA TGTAGATTAG AGTCAGAAGA GCAATATACA AAAGACAAAA GCTGAGAAAT TATAGTAGTT TATGGTCCTG GATAAGTGCT CATGAAGGAT CTCAGGAGAA ATGATCACAG GTAGAAAGAA TGAGAAAAGA GTGATATGAG AGAAACCAAG ACAAAGAAAA GTAAAATGTT AAAAATGAGT GAAATAGGCA TACCAATAAT TAAAAATGAG TAAAATAGGC ATACCAATAA CATAAGGGTT AAAAAATAGA GTTCAAAAAT GGGGTGAGGG TAAAGTATTA GGAAGGAGTC ATGGCCCAGG GATCAAGTGA AATGAGTTAG ATCTATAGAT CTATTTCAGT TGGTTGACAT YFAAATGTAT TTITGGT1TTA ATTCTTTATT GTTTACAAAC ATTGCTTTTT TAAAAAATTA AATTGTCCAA I'TCAATTCAG GCTCACAAGC AAGTGCCTCA TATATACAGG CAYI1TTGTGG ATCCCAAAGA TGCAATGATA AATAGGACAC TTACTGATCT CAAGAAGTTT TCAGTACCAG AGGAGACGGA CAAGTGAACA GATGACTFCA ACATAAGTGG GAGAAATGAG GAAGAAATAT GTGGAGCTAT CAGAACTAAG AAAGCTTcCT AGAAGAAACT GTCUTTGAAC AATGTCTTAA AAAGTCAGTG TGCTACAGAG GAAAAAGCAA GATACT-TCT GAGTTCTAAT TAATCTAACA CCYJ7ATGGTA ACCCTGACAG AAGTGAGTCG AAACTTCATG

TITTCTGATCA

TATAATGAFIT

GGCCCATAGT

TGCATGACCA

GTACTCAAAG

TATTTGTAAA

CATAGGCAiT

GTGGCATACC

CAATCATTTC

AATTTGCTAA

TTIGGAAAATG

ATTITTATAT

TGTGAAAACT

TATTATCAAA

CTTGATrrAG

AAACTTCCCA

CCTGTGACTT

ACCCCACATC

GGGCTGGCAA

TCATTTCM~

TTICATAGCAT

TATTTGC1TTT

TTGAAACTCT

TGCATGCAAT

AACGGTAGAG

CTGGCTGTTT

AAAATTATAT

GAGGTGATGT

GGCACTGATT

GGGTATAGCT

AGATGACATG TTTTTTGGCC ATGTGCAAAA TGAGAGAGAA GGCCACCAGC CACATGTGTT AAGTGTGGAG AACTGCAAGA AGGAAAGGAA CTACTAGAAG GGGTAACTCA GCCTCCTAAT GATAAATGGC ATAGTrCTT CCAGACCTTA AGCTCATTAG ATCGTGAGCT TCTTGAGAGC GGGAATCTAC CATGCTAATT CTI7TTATCCC AACACTGTGC TTCTTGTGGT ACTCAAAAAG ACTTGTTGAG CTGACT-rATG AAATC1TTAC GGAAAGGTAA CAATATTGTG AAAGCAGAGC 1TTTCTCAGAG TGGCTAGTAT CATITrTGTTC CAACCAGCTTr CATGATAAGC TACCTAAGAA GAAGCAAAGA AAGGAAAGAG ACTTACCAAA CTGACACTGG ACAGTTGCAG GTGTAATTIAT TGATGATTTC TACACATT1CT CCATGGCCAC GAAGCTTTAA GGAGGTCAGA AAAAAAATAT TTT7AATGTGA YrACAT1TA AGACATAGAT AACCTTTTGT CTGAGATGAT TfTAAATAATC AGGAAAGGTT AAAAATCATA TGCTAAAATT TTTACGTATA AAATACACTA AGCATATAGT TGGAATGAAA TTACCAATAC TAATATTCTG TAACACTTAT AGGAAACTTA TGAAATTACT TGTTITAAT GAGTGAGAAG GTTAAATGAT GACCTGACCT TATTTCT"TGG CAATCCCTTT CTTTATAGAA ATCAAAGATT AAAAAGTCCA TCCAAYITAT AAGAGACCAA ATTAACTATG GTTCATTATT AAAACATCAC TGGAATTGTA GAAGATTTTA CAGAAATATT CATACACCAA AGATAGTGCA AAGGTTAGAC CAAGAAGGAA GCACGCAGCA CCACACTCTC TACTFCACAA GAGCCTAAGT TTCCAACTGG CCCCAGCTGT CAGCTFCTCC TCCCCTGCCT GTCTAGCTCT TCCTCTGTAC TTCCTACGTA GATCTATCAT TTTGATGTAA TT'TGTGCACA GGGACAAATC 17ACACACCA AAAATTC'rrA GGAGTGACAC GATGCAAGAT TATATAGAGG GCTAGATGTA TTTTAGAATG AACCAGAAGC TGTTCTCATC CCCCCACC1T TCCATGGGGT AAATCTGAGT ATTCTCFJ7AA CCGTGGCCCT TCACTCCCTA CCTGTGTAAC AGAGGGCTGC CTT-rAGTTTG TCTT7GTTTC TCTTGATATA GATCTCCACG CAGTCCTCCT CCCAGTTCTC TGCT-rCTUCA GTAAGAGATT TG11TGGTrCC GATTCCTATC CAGTAGTAAG AACGACTGAA AGGCAGAGTC TGTATGGCAA CTAAATCTGT GTAATTGTCT CGGCAGAATC CAGAATAATG GTAAGTCCAG CAGTCGGTTC CATGATGTGC ATGCAGACTT ACATAATGTT ACAGCTAAAA AGAACCTAGC ATGAGGAAAC AGAGCCTAAG AGTGTATGTG ACCATCTCAG GTAGAACCTA GACCTTCTGG CTTGAATATA AGATGCTTTT GGTT-rTCTAG GTTTATrrTC TrATTAATTT TTrTCTCAAA YTTAGACATT CATATCTT TTTCTTTGTA GCTGTTAATG TAACTATACA ATTTACGTAT ACTMTTAAT CCTGGAATCA TCCTGAGTCT GAGGCAGCAT TGGCAGGCGT CATCGTTCCA TGTTCTTCTT GTTGTTGGGC CACCCACGTC CATATTCCTC TTCTCCAGAT ACTCAATT-TC TTCTAGCCCT UTGCCAGTTC C2AGGAAATCT GCAAGACATC ACTACTCCAG GCTGAGCTAG GATCACAGAA TAGUTGTTTG ATCTAAGGTT CTATTTGAAA VTATTTCAG GTGAAATTTA ATTrACAACT AATTACCGTG TTTCTTGAAG GCCAACACAT

AGCCGTCTTG

TTTGCCTGCA

TCACCATCTC

CTATCTUCCG

CGCCTTGTTT

ATGGGTT

AGTGTGACCT

ACACTI7AGAG

CAGATTTGAA

CAAATTJTAGT

ACCAACATAT

TAATATCATA

ATGTACCTAT

GGGAGAAGCA TAATAAGGAC AGGAAGAACA GTGACATACT TTTAAGTAAC CTCTTI7TACA TAAAAAACAT ThrATITrAC CATAGGAAGA GTATAATTTT TAAAAAGAAC CTATACACAA AGAGACTCAA GATATCTAAT TAAACACATA CTACATGAAT CACTATTTAA CATTTTGAAC AGAGTTTTGA CCACTGCTGT ATCC1TAGTG GAAAAGAGCA CTAAGTTTCT

ACTGCTTCTG

AATTTACAAA

CTGATGATGT

ATTACACAAT

TACAGTAAAG

ATGAGCATTC

CCTAGCATAA

ATGTGACACA

GAAAAGCCCA ATATACCACT GCCAAATGGT ATAGGATTAT TTAATAAACA TATGGACCCA GACTJTCATAA TAATATATGG AAACAGATAT AATJ7GATGGT CACTAGAATG CAAGTTCTAA ATT[CACACA TTFGTAGGGAC GTGCAGACAT GGCATAAGGA

CAACTCTTAT

GAAATTCATT

TCAAATATGA

CATTCTAAGC

AAAGAGCATC

GAGGGAAAAA

TCAGAAAATA

ATGTGTGAAC

A17AGTTTAC

AAATTTGTCA

AATTGTAGAA

GTACAGATTG

GGGGTTATTG

ATATCTAACT

AGATCATGTT

GGGCT-rTGAA

ATGGTATGAT

ATAAAATAAA

ACTGYJ7GTGT

CCTGYJTGTAT

GGGAGAGTTA

TTAGGAAATG

CAACAATGGG

ATGACATTAA

TAAGTACCIT

GGA'rrTGAAC

GCATGTTTGC

AAAAACCAAG

AGAAGGACCA

TGTACACTGA

AACAGAGATT

TCTACAGCAT

GAAAAGAGAT

ACTAGTGGAT

CACAACAGAG

CCATGGAAAT

CCTGAGGT

GGTAACAGGT

11TTGTTCTAT

TTTGGTAATT

TITTTAAAGT

CATAATGGGT

TATTTCTTTI7 1 CAcc'I1AAAA

TGTGTGACAA

1TCCAAAGCA

TCAAGAGTCT

ACTTTI'TG

TCCTATCCTT

AAAGGCTCAC

ACAAGGGTCT

AAAGCCTTGC

TCCTCCTGCA

CAAAAATGAA

TTCCATTCTC

cTrcTTi-c CYTCCTCCT-r

AACTAACTCT

CAGACATATT

CACCTCCGTC

1TGGCTAGAG CTGAAAATCC AGGCTAGGGA TTCAAAGCTA TTGCTGGAGA GTCTfTCAAGA AAAAATGATA AACCCCCGTC CCTfAATAAG

GAAAGAAGAC

ATCAGATATA

CTCGTAT'TGT

ACTATGAATA AAAAATAGAA TCTrAATTAA CATTATTCCT GGGCTATTAT AGGTTAAAAA GYITTACAGAA GGGATAGAAT ATTTAAGAAA AATGAATATA CATTGTCCAC CCCCACAACT AATGAGGTGC TAAATATTTG TTATAATTGA GGGA1TFGT TAGTGTTCAG GAGTTTCTGG GGAAGAACTA AAGGTAAGAA TAACAGCTCT GTGAAATAAT TTI7CCCTTAG ACTATGTATA

AGTAAAATAG

TGAAGATGTT

ATJTATAT7TA AC'rrAGCGAT

CCATAAGTCC

GATGTATACT ATCTGCAAAT

GGTGCTTACA

TTCTCAGACA

TTTATFTfTTA

TTTATACCTG

ATTGTTGCTG

CAATGCCTCA

TF7AATAAAA

TATACTTAAT

ACCTGTATGT

TATCACTITCT

CCCCAGAGAC

AGGGTCTGAG

G3CCACCTGCC

GAAATACAAA

ACTT~rCTI7AA TAATCAGAAT AAAACACATA TAGATGAAAA ATTACTTCAA ATTTACATCA

CGCTTTAGTC

C1T[CTGCT

CTTAATTAAC

AATACCTAAA

AGAAATACCT

GTAAATGACG

TGTGCACATG

CAGGTAGACA

AAAGTCAAGA

AAAATGTTTA

TCTACAACCC

TCAAGTTGCT AATCGGTACT GAGCTATTAG ATAAAACTAT TAT[GATGCT TATATTTAAT AAAAAAAAAA ATTAGATAGC TTT-FGAGCAA CTGAAATGAC

AGTTAATGGG

TACCCTAGAA

CAGTGTTTAT

AGAGGAAATC

GTTTCTATAT

CAAGAGTTTC

CTCTAGTTCT

GTGTGCTGTG

CAGTCTCACA

TGCAGCACAC

CTTAAAGTAT

TGCAAAAGAT

AGCATATCTG

TAT1TAAAAC

TATCTGAGCA

TCTGCAGCCC

CTGCAGGTAG

TCCTCCTCCT

ATATAAATAT CATAACATAC CTCTGGGTGC TCTGACATTT CTTAAACCAC ACATYJ7ATAG TGTCTACTAA CCCTGTCTGA GAACTGATGC ACAGM~TGT GCCCTGAATT TTTTCTATGG 'nTAATATTTA CTATGTATAT GTTATAGCCT CACTCTTGAT CAGACACCAG GAAAGAAAAG AAAGTCACAA ATTTCCTGCA CAACATGGCA CATGTATACA AATTTTAAAA AAATTCTATC CTGATTTCAA TAGTAMlCT AGAAGAAAGA TTTCAGGATC CAGAMTTGAA ATGGGGTGAT TCTAAACGTC TTTTAGGCTG ATTGAGCCTC TTGACTrFAGC ACTGCACTGA ATGTCAACAG CCTCCCCT[ TCCCTCCCCT TCTATTGCCT CCCACTGAGA TCCCTCCTr CTATCCTTCC TTGTTGCTGT TCTTCU7CCT TGTrGGTTC TTGYITCTCCT TATCTTT-FTC ATAAATGCTA TACAAATCAA AACTGCATTUr CATGGCTTTG CTTGGTCCIT

CAGGTCCYITG

TTTCTFTCAT

CTTCTCTTTC

CTGCTGATCA

CTATGCATCT

CTCCTGCTCC

CTCTCTCTCC

TGGCTACCTG

TATGATG1TT T1TCCTTGCT

CCCAAAGGGA

TTCTCTAACC

CTCTTTCCCC ACCCCTFCC TAGACTGGCC GAAAGTAATG TGACTAGA'IT CTCTCTTCCT

TTCCTTACCC

TCTrCTTCTA

TCCTCCTCCT

TGGTAAATGG

GCAAAACTTC

CACCACCTAG

AGCYTI7CAC TTrATAAGAC

TCCTCCTCCT

CTTGTUCTTG

TCTTrTTCCAC CCCTrGGAAA

AGTAGAGCTA

TGGACGTCCT

CGTGTAGGT-r

TGCATGTGAA

TCACTCATTG

T[CTFGTTT

CACCCTCCCC

TTGCAAATAC

GAAGAGAGCC CATGCTCTCT GGACTATAAA ATGAGATGGT AAGGAAGACC CACTGATGTG TAACAACAAC AAAAACTCTG AGCAGTGGAC TTGACTCGYI7 TGTTAGTGGC ACTTCCTGAA TGGGAGCCTA CAAGTACCTr ATTAGGACCC ATATGATGAA ATCAGATG CAU7TTTAGG ATTATATTGT TTAATCTTTA

TCGGYITCCYT

GTTAACCCCT

TAATATTCTT

GGACAATAAA

AAAATAATAA

TAACAGCTCT

AGTCAATGAG TCAAATGCAA AAGCTCAGCG CCCCATAT[ CTGCTATAGA TATGA11TATT ATCCCCATITC TAAAGAGTCT CAAAGAGGFF AAGAAACAAA TTCAAAAACT AGCGAAAGAC AAGAAATAAC TAAGATCAGA GCAGAACCAT AGGAGGTAGA GACACGAAAA AGCCTTCAAA AAATCAATAA ATCCAGGAGC TGCATTTrGA AAAGATTAAC AAAATAGATG GACCACTAGC TAGACTAATA AGAAAGAAGA ATCAATAGAC ACAATAAAAA ATGGTAAAGG GGATATTACC ACTGATCCCG TAGAAATACA AACTACCATC AGAGATITACT ATAAACATCT TTACACAAAT AAACTAGAAA ATCTAGAAGA AATGGATAAA TTCCTGGACA CATACACCCT CCCAAGACTA AACCAGGAAG AAGTCAAATC CCTGAATAGA CTAATAACAA GTTrCTGAAAT TAAGGCAGCA ATTAATAGCC TACCAACTAA AAAAAGCCCA GGACCAGATG GATTCACAGC CAAATTCTAC CAGAGOTACA AAGAGGTGCT GGTACCATTC CTTCTGAAAC TATTCCAGAG AATAGAAAAA GAGGAACTCC TCCCTCACTC ATTTTATGAG GCCAGCATCA TCCTGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA AAATTTCAGG CCAATATCCC TGATGAACAT CATI'GGGAAA ATACTCAATA AAATACGGCA AACTGAATCC AGCAGCACAT CAAAAAGCTT ATCAACCACA ATCAAGTTGG CTTCATCCCT GGAATGCAAG GCTGGTTCAA CATACACAAA TCAATAAACA GAATCCATTA CGTAAACAGA ACCAATCACA AAAACCACGT GATTATCTCA ATAGATGCAG AAAAGGCCTT GGATAAAATT CAACACCCCT TCATGCTAAA AACTCTCAAT AAACTAGGTA TTGATGGAAC GTATCTCAAA ATAATAAGAG CTATTTATGA CAAACCCACA GCCAATAGCA TACTGAATGG GCAAAAACTG AAAGCGTTCC CTI17AAAAAC TGGCACAAGA CAAGTATGCC TCTCTCACCA CTCCTGT1TCA ACATAGTATT GGAAGTTCTG GCCAGGGCAA TCAGGCAAGA GAAAGAAATA AAGTGTATTC AAATAGAAGA GAGGAAGTCA AATTGTGTCT GTYJTGCAGAT GACATGATTG TATATTTAGA AAATCCCATf GTCTCAGCCC AAAATCTCCT TAAACTGATC AGCAACTTCA GCAAAGTCTC AGGTTACAAA ATCAATGTGA AAAAATCACA AGAATTCCTA TACAGCAATA ATAGACAAAC AGAGAGCCAA ATCATGAGTG AACTCCCAT[ CACGATTGCT ACAAAGAGAA TAAAATACCT AGGAATCCAA CTTACAAGGA ATGTGAAGGA CCTATTCAAG GAGAACTACA AACCACTGCT CAAGGAAATA AGAGAGGACA CAAATGAATG GAAAAACATT CCATGCTCAT GGGTAGGAAG AATCAATATC ATGAAAATGA CCATACTGCC CAAGGTAATFT TATAGATTCA GTGCTATCCC CATCAAGCTA CTACTGACTT TTT[CACAGA ATTAGAAAAA AACTACTTTA AATTTCATAT GGAACCAAAA AAGAGCTTGT ATAGCCAAGA CAATCCTAAG CAAAAAGAAC AAAGCTGGAG GCATCATGCT ACCTGACTTC AAACTATACT ACAAGGCTAT AGTAACCAAA ACAGCATGGT GCTGGTACAA AAACAGATAT ATGGACCAAC GGAACAGAAC AGAGGCATCA GAAATAACAC CACACATCTA CAACCATCTG ATCTTTGACA AAGCTGACAA AAAGAAGCAA TTGGGAAAGG ATTCCCCATT TAATAAATGA TGTTrGGGAAA ACTGGCTAGC CATATGCAGA AAACTGAAAC TGGATCCCTT CCTTACACCT TATATAAAAA TTAACTCAAG ATGGATTAAA GACTTAAATG GAAGACCTAA AACCATAAAA ATTCTAGGAG AAAACCTAGG CAATACCATT CAGGACGTAG GTATGGGCAA AGACTfCATG ACTAAAACAC CAAAAGCAAC AGCAACAAAA GCCAAAATTG ACAAATGGGA TCTAATTAAA CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT CAAAGTGAAC AGGAAACCTA CAGAATGGGA GAAAATTTY[ GCAATCTAYJT CACCTGACAA AGGGCTAATA TCCAAAATCT ACAAGAAACT TAAACAAATT TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA GGATATGAAC AGATGCTTCT CAAAAGAAGA AGTTITATGCA GTCAACAAAC ATATGAAAAA AAGCTCATCA TCACTGGTCA TTAGAGAAAT GCAAATCAAA ACCACAATGA GATGCCATCT CATGCCAGTT AGAATGGCGA TTAUTAAAAA GTCAGGAAAC AACAGATGCT GGAGAGGATG TGGAGAAATA AGAATGCTTT TTACAGTGTT GGTGGAAGTG TAAATTAGTT CAATCATTGT GGAAGACAAT GTGGCGATTT CTCAAGGATC TATAACTAGA AAAACCATTT GACCCAGCAA TCCCATTACT GGGTATATAC CCAAAGGATT ATAAATCATT CTACGATAAA GACACATGCA CACUTATGTUT TATrGAGGCA CTATTCACAA CAGCAAAGAG TfGGAACCAA CCCAAATGCC CACCAATGAT AAACTGGATA AAGATGATGT GOCACATATA CATCATGGAA TACTATACAG CCATAAAAAA GGATGAGTTC ATGTCCTTTG CAGGGACATG GATGAAGCTG GAAACCGTCA TTCTCAGCAA ACTAACACTG GAACAGAAAA CCAAACATTA CCCATTCTCA CTCATAAGTG GGAGTTGAAC AATGAGAACA CATGGACACA GGGAGGGGAA CATCACACAC TGGGGCATGT CAGGGGATGT GGGGCTAGGG GAGGAACAGC ATTAGGAGAA ATACCTAATG GCAGCAAACC ACCATGGCAC ATGTATACCT ATGTAACAAA CCTGCACGT[r TTAAAGTATA ATTTAAAAAA AGTTTAAAAA AAGAAAGUTG TTGGGAATTT GAACAGAGGC CAATCAGTTIC CAAATCCATG GAACY[rGGAA GACATGGTAA AATGGGGAAA AACGTGGAGC CACTATACCC TGAAAGAAGT ATCTAGACTT ACTJ7TTTfCT CTCTCTCT'IT CTCTAAGAGA TGGGAATGCT GCTCTGTCAC CTCATrGCAC

AGGCACATGC

GCTCAGGCTG

TCTCACCAAG

GCTCCTGGTT

AACCTCCAAA

TGGTCCAAT7

AACCATTCTC

CTCTCATAT[

CCTFI7CCATC

GACACCTCTC

ATTTAAG

CAGATI7AACA

GAGAGAGGGG

TGAGACATGC

AGTGACCTTG

CTCACTAGCC

TTGGGTTTTG

AGAAGCCAGA

ATAGAGACAG

ACAGAGTTT

ATAAAGAATT

TTrACAGGAAG

AAGGTGAAAG

TCAAGGAATC

CCCAACCCTC

TAATTCTGTC

GTCCTACACT

TTCCTCCTAC

CCCTfGGAGT

CACACTCTTG

CTGTAGCCAA

TTACATATCC

TCAGTGGATT

YTTI'TCA

AAATCAGAGA

CTAGGGTCTA

GACTAAT1TTr

TFGAAGCTTG

TCACTAACAC

TTCACTGGCT

ACTCCAGAGA

ACT-ITGAATA

ATGCCTACTC

CAAACTGAAC

ATAACTCCAT

CAAGTCATAT

GACCGATGGG

GTGCCCC1TC TITTATITTr

TCCAATCAGG

AAACAGCCTA

ATTTCITCTG

TCACCGCTTT

CCATTTAAAT

AACATCTCCA

TTCTGAATT-r CCTI7AGTCAC

CTCTTGATCA

CAGGGAGACT

AAGTCCTCTC

rCAGGCTAGA

TCCCTCAGCC

AT1TTGTAG

CTTTCAGCCA

TTCTCCATCC

TATCATGTGT

GCTCITCTGT

GCGAACGAAT

TCCCCAAACA

CTCCTCCAAT

TAGATGACAG GUTGATGAAT CTGCTCATGT ATCCCAGAAA ATAACTAGTA AGAGACATGG TTAAGCTGAA CTTrATGGCAG TGTGAAAGTG CCAGTGCTCC CTCTAAT-rCT CTCAATCTCT GTGCAGTGGT GCGATCATAG TCCCATGTAG CTAAGACTAC AGACAGGATC TCACTATGrr CACCAATYrCC CTGAGACTGC TCATCTTACT TCACCAGGGA TGATTCTCCC TCATCTCCCC GTCTAACCTC ACTAACTTGG TCTAAATTCT GTACAACCAG AATTTAGTTG TTCAATAAGC CTGTAGGGCT CTTCCCACAG AAACTTTrTGG AGTTAACTGA GGTAGTGGAA ATATTGCGGG TITAGGTGCA CTGGCCAAGT TTAAGCATI'T TGTGGGGTGG CCTITCCAGTT ACTCAGACCA CCAATGTGTC AACAAATTTT TCCAAAGGAC TGAGCCCTGA TATCTGTGCA GGGGGAAGCA ATTACATCAT TrCTrACT CAGCTGCACA GCTAGAGAAA

ACAGAAAAAC

TTACATACAA

TACAAAAGGT

AAAGTAGATT

CTTCTGATAA

ACCTGAGACT

CATGGTGCCG

GGGAGCAGGC

AGGCAGTTAA

CTGAGTCC

TACATGTTGT

AGAGGTI1CCC

AAATATTTTG

TGGTAA'TrA

GTJTCAGGAGG

ACAAAGAGTT

TACTACAGAA

TCAAGAAGAA

CAGGGTCTTC

ITTTAAAGG

GCTrACACAT

CTGATTCCAT

AGGGGCTGAG

GAACTAGATA

TAAAGAAAAG

GTGAGAAATA AAGACAGTTA TrCAATTAAT ACATGTT1G CGACTTGAGT TTATCTGTCT ACAATGCCTG GGAAAGGAGG AGAGGTAAGT GCTCCAGCTC TITCTCT-TTC TCAGGGGGAG TAIT[7AATTT CTTTTAATTC CTGTTCCAAA TTATATGAAA CATATAGAAG AGGTAAATCC GAAGAAATGG GGACTAACTG C1TATAGGGT GACATT1GT TAGGCCATTC T-rGCATTGTT ATG=TAAT7 GGCTTACACT TCTGCAAGCT

ATATI-ATTA

AAGTTACCTT

ATATCTGCTC AGCT1TCTGGT AAGGCCTCAG GAAGCT-FACA ATCATGGCAG ATATCACATA GCAAAAGCAG GAGCAAGAGA GGGATGTGGG GAGGTGACAG TCACTTAA ACAGCCAGAT CTrGTGAGAA CTCATTCACT ATCATGAAGA CAGTACCAAG AGGATGGTAC TAAATCATTC ATGAGAAACC GGATTACAAT TTGACATGAG ATGCGATAAA CGTCACTGGA AAAAAAAATA TTTAATGTAC CAGCCATfTG ATGGGTGjGTA AGATCGAGTr GGTGAGCATT TUGCCTGCCA TGAGACATGA TGGTCAAAGG ACCACTACCC GCTCATTGCT GCCAACCAAG CCACCCTCAT GATCAAATCA CCTCCCACCA ATTTGAGTGA GAACACGGAT CCAAACCATA TrGTACACTT TAAGATGGTT GTrTATGTT A117CAGCCAA AAGAAGATTT GGAATAGGAA AGGAAAAGAG TGGTTATTAG ACTGTTTTGT ATAAAACCAT CACAAAACCC

GGGAAGTACC

AACCTrCCC

GCTGCACTCA

CAGTAGAGAA CTAACTAACT GCCCACCTAC TCCTfrACAT-r TGGCATGTAA GCCCCTCU-A TCTCTCCTGA CCCAACCTrG AYITTCATCC ATCACCAAAC TCCCCTCAAT CT-FCCAGTTT GCCCGACTGC CTCCCTAGGA CATCACTTCC AGGACATACT TCAGGGTTGG AAGGCAGGGG ATTCATCTGC CCTCTTGTAA AACACACACA TGAAGC11TGT GACACTGAGA TAAACCATCT GATTGGCTTT GGCACCTAGT TCCTGATCTT ACCATCCATG GCACAACCAA TACCACAGCC TTGAGCTACC TCCTI7cCCTA GGCACAGCCT ACATGTTCAA ACACTTCACT CYTTAACCAC TGCAATGCTT TT-rACTTCTA CCTCATTGAA GTTTCTCCTT ACTTGTTTGT TTGTTTATTT TGTTGCCCAG GCTGGAGTGC AGTGGTATGA TITCTCATGTC TCAGCCTCCC GAGTAGCTGG ATTfYITATTA GAGAAGGGGT YI17GCCATGT CCTGCCTCAG CCTCCCAAAG TGCTGAGATT T-ATTTCAAG TCTATGCTGC ACTATTAAAA GTGAAAGAGA TCTGAAATAA TCAACCCCCA GCTTGGGCCA AGCTATCTY[F GGCAGAAATT AAACTGCCT[ TGTAAAACTA ATAAAAGACC GCTAAGGTGT AGATGTAAAC AATTACCAAC ACTCCTGCAG ATAACAGCAC TATCATAGAA TTCAACTGGT GGCTCTACCT GGACCCATCA ACAAGGACCA TTircCACAC CGCTATGATT AAATTATCCT TGAAAAATCT TAGCCTIAGA TCTCCCATTT GGCTGGCTCT GCATGAATTA TITATCTGGG CAGCAAACAA AAGGAACCCA AATTGGMTU- TTGTTTAATG AATTTATTCT TCTCTTTATT TCTTGTTGAA AAGAACTATA

AGTGAATGCC

TAGCCTACGC

CTGCAGTTGC

CTCCACAATC

CTGTCTGTCA

CAAATGC1TC

CCTGTTCAAA

CCTGCAGATC

TGGAGAGAGG

ATTGAAAGCA

CTCCATTACA

TATCAGTrTA

CTATCAGGAC

TCTATCTCCT

CTTGCCATCT

CTTTTCTCCT

TCTCAAGATG

GGCCCCACCT CCAACACTGG TCAGAGATGG TGGTTATACA GTGTGAACT[ CACCTCAATA AGGTCATGGA GATATATTAA GGCCCTCAAA AGGTAGAACT ACCCAGTGCT GAAGAACCGT GCATCCCTGG GTCCAAGGGA GATGACCGCA AGATTATTf TCATGGGTAA AAGGAATGTG AAATCACCAT GGCTCACATT ACACAGTTCA CCTAAACTGT CTGGGATTCC TGTCTTCACC ACCTCCTTGC 'TrTGTCATTA ACAATATTTA TTCTCCACAC AGTGCCTCTT ATATATGTTT ATAAAATAAC TCTGCTTCTT CCTCTCAACT CCTCATGCAA TCATAGTCTT ACGGGACYTFC GACAMCC TCCACTAGAC CAATCTTCTC CTTTATAATG

CACACACACA

CACTGTCCTC

CC117TCCCTG

CAGATCCTCA

CAAAGAAGAA

ATTGTAGTGA

TAAGCACTTC

GCTCTCCAAT

CAACCTCGAC AACACCTAAG ACTGTACCGT CTCTAAAGTC TGTCTCCTAT TCTTGCAAGT GTA11TGCTCA AGTATCTCAT CCTCCAGGCC A17AAACATT TCCTTATTTC TAACCATCAG GTTTCTTTTT YITTTTTTTT TTTGAGACAG GGTCTCACTC TCTCGGCTCA CTGCAGCCTC CATCTCCCTG GTTCAAGTGA GACTACAGGT GCATGCCACT ACGCCTGGCT AAGAUTTTGT TGGCCAAGCT GGTCTCGAAC TCCTAACCTC AGGTGATCCA ATAGGCATGA GCCACTATGC CCCACCTGGT TTFCTCCTTAT CTGCCTTGAC AAAAATTATA ATAGTGAGAA AATTATGACA TCT7GCCTTT ACCTTCCAGA CTGCCCTTAA TAAYFCCTGA TAGTTTATAG TTTAAATGAT AATAGCCCfl CTCCAAAACT ACCAATGAAA GGTTAGGAGG ATGAGAGGAG CCTGAATTCT TGTTATTCCG GAGGTCACAA GATTTGCAAC ATCGCCAATT TCTGATTrGGC CTIGAGAT GTCTTTTCAG ATTC'FrACAT

ACAAGTCCTG

GCATCCCAAC

AYI7TTGGGGG

AATTCTTTCT

TTGGACAGTT

GTTTTCTTGA

TTGCTACAGC

TGGCTCCACC CAGAAGCAGA CAATCAGCAG CAACCATTCC AGGCTGATTT CAGTAATAAC CTA'ITGCAGT TCCCATCTTG ACACTGTTGG CAGATATATC TATTTACAAC TGTGAATGTT CAGTACATAC AGATGGATAG

CTTAACATGC

TCTGCCTGCC

AAAACCCCGG

ATAAATCACC

TTGCTTCCAA

GTGTCTGAAT

CTAATTACTC

AACACGGGGG GATGTGACCA TCACCGCACT GTGCAAATGA ATGTTACCCA YJ7GTCCACT-r TI1CCCAAACT ACATAGTGTT ATATGGTATA TGACCCAATC AACGGTGGCA GACACTTTAA ACTAATCAGC CTATAGTCCT TITGGTAACAT TAAAAAAACA AAAAAATATA TT1GGGTTGGT TCAGGAACAT TCAGGAGTTT AGAAAAGGAA CGTAAAAGCG TCTTrGCTTTT TAGGACCCAG GCCC'rrGTAA Y[TAAAGGTT TCAGGGCAAA TTACCTGTGG GTTAGGGTfT GTACGCTTGT GTGGATT]T TMIrT=T GGAGTGCAGT GGCGTGATCT CTGCTCACTG GCCTCTTGAG TAGCTGGGAC TATAGGCACG TGGGGTTTCG CCATGTTGGC CAGGATGGTC AAAGTGCTGG GAYI7ACAGGC GTGAGTCACC GTGAATACAA AACTAGATCT TTCCCT-7CTG TCTT-rTAGTA TCTTFCCMT TTFCTCTCTTA AAATTTTC CCT-T-TATTT CTA11TGACCT ATGGGGATTG AAATAATTGC TGGACTTG GCAGTTGATA CATAACTAGG TTTTAAAGTC TCTACTTC11T ATrATGAGCC AAAATATGCA T-rGTTGGATG TCCACTCTGT ATCAGGAATG TCCCTACCCC TAAGGAACY[ AGAGTITFAGTC ATCTATAAUT AiTTAlTACA ATTAAAGGAAC CTAGTGTAAG TAGCCAGT-rC TCGTGAAGGG GGTGTGTGTG TGTGTGTGTG CGTGTGTGCG AATITGTCTCA CACAAT-rATG GAAGCTGAGA GCCAGTGGAA TACTTCAAAG TCCAAAGGCC4 TI17TCAGTAA

CACGCAACA]

TTCAGGGTCC

ATAGiATCTTA

TATCTAAGTA

AGGAATATAT

TTT17TT7C

CAAACTCCGC

CACCACTATC

TTGATCTCTT

ATGCCCAGCA

TAGCATCTGT

'FfACTI'CCTC

TTAGCCCTCA

AGAGATAGAT

TAGCCTTCTG

TTCATTCACC

TGCTAGGTTC

3GGGAAGACA 3GAAGAGACA ACATGTATT7A

TGTGTGTGTT

AGTCCCATGG

AAGCTCCAGA AATACCACAT AGACATCAGG T1TCCAAACC TGGTTGTGCA TCCAAATCAC UTCGCTCCCAA TCCTACTGAA TCAGAATAT7 AAGGTTTATA TAATTTGAGG TCTCTCTTTG CAAAGATGTA UTACCATGTA AACACATTCC ATGGGCCCTG AAGCTTAAFIT TTCATTATCT CTCTCTGTGT ATGTGTGTGC ACATTAGCAT TGAGACAGAG TCTCGCTCTG TCGCCAGGCT CTCCCAGGCT CAAGCGATTC 'rrCTGCCTCA CCCAGCTAAT TTTJ7GTATTT TTAGTAGAGT GACCTCGTGA TCCACCCGCC TCCACCTCCC CTTGTGTGGA TGTUTTAAGC TCCCAGGTGA ACTGTTrTACT CTATGCATCT CAATAT-T TrGTGCTATr ITTACACCTC CTITTTAAA CAATGATTCC TACAAGCCCC AYITTCTGTAA ATATTAAATT GCAAACTGGC AGTAGTGGGG AGACCACTCA TrrCCATTrGT GAAAAGTGAT CATGGATTGA TrrTATTrCA1-r CAATAAATAT TGGGAATACA GCAATGAACA AGGTAATTTT GACAYITAAAC AAACAATTGT GCAAGTAATA TATOGATTAT GAGGGCATTA AAGAGGAGAC GTTGGAGTTC TCCAGAGAAA CAGAACCAAT GGGGTGTGGG GGTGTGGTAT TT-rTTATAGA CCTGCTGTCT ACGAGCTGAG AACCAGGAAA CTGGAACCAA GAGTGCCAGT GTTGGAAGGC AGGAGAAGAT GGGTGTCCCA GCITAAAAAG ACAGTGAATT CACTCT1TTT GCTCTACATA GGGCCTCAAT GGG11TGGATC ATGGCCACCC ACATTGGTGA CTCACAGACA CACTGAGAAA AGCTGTACAA TCACATACAT TAAGAAAGAG ACTTAACACA TAGGTCTGAC ATAAGCTTAA T-rCTCAATAA AACTCAAACA ATATTTACAA CAC'rrAAACA TGTFCTCTCT TATTTCCCAG TCTCTGTT7T GACTGTTGGC CACATGCTAA GTTAATGGAA CAATTACTGA CTGAGAATTT ATCTGCTTAT AAATAAACAT AGGCAATCCT CTTAGTCTAC CAATTAAATJ kCTAATCTCTT TGGAAATACT TGGAGTTAAA CAATGGTGAT TAATGTTTTA

TTTTAAAGGG

GAGATAAACA

ATAAATATAT

CAAACCACAC

ATTTCAAAGA

AGTTTCTG

TT-FGTTGTTG

GTGTAGGAGA

TTCATTGCCA

AAATGCTI'GC

TCAGGGTGAT AGAAATCTTC TGCGTTTTAT GGAAAGTGA( TAAGCACATT TATTGTCAA ACTTTAAAAA TTATAAAAT~ TGGTATTTCA CACAGCTAA AAATAACACT GTATTCCATA CCCC'ITTAAA AGAACCTCTG CCAGTGTTCA GCCAGAACT1 GTTTTGATTC TCACACTCCT GTGATCAACT GAAAACTGG) TCACACAGGC ATJ7CCTCTCT

-J

c k-

TTTTATCTAA

CTTTATAGTG

TTTTAAGTTA

TTCTAATGCA

CATAGCCTGA

CTGTTCTGAT

CTCTGAAACT

CAAGGCTAGA

GATTCCTG

ATAAAATTTC

TTATGTCAAA

TAATTTAAAA

GTTTACATAA

TCACAGTAGT

CCTTATCACA

FTTTTTCAA

GCAGCTTTGG

GAATTGTTAA

AGAAGAAAAC AAATAGGGAA TAACTAUTAG ACATCTTCAT TCGTTAAAAA AAT-rTAAAAT C1TrCCATAAT ATACAAGAAT CATGGTGAGT

GACAAACATC

AAATTATACC

CATCGTGGAA

CCAATTCTAC

GCCTTGCTAG

AACAATGAGG

AAGTCCCTAC

ATCACAATCC

GTAACCCTCG

YITCAACATCT

TTrATTCATTC

CACAAAATAT

TI'TCAGAGTC

YI'GATCCTGA

GATCTATTGA

TTCTATTGTG

1TTGTAc3GAA 1TGTGTGTT

ACCACATATT

CATGTTTTCA

GGGACAATAG

GGGTAATCTA

CACACTTGTA

TTAAGAACTC

CACAGAGCAT

GTCATJTTTTT

TTATGACAGC

TGTGT11TCTG

TTGGTCTCTT

TGCAAAGCAC ATCCATCT-FT CTGTATTCTT TGCA17ATG CTTTTATTAG TTCAAAACGT TCTGAAAAAA TATCTGACAA TATACAAACC AAAAACAACT GTAGTAAAAA CACTCAGAAC TTTCCCTTTT TGAAATAAAT TrAAAACAGA GAATAAGTAA C1TMACCAT ATCATAGTTG TTGAATGAAG AAGTATGGAA GATfATAATA TYFAAGAAGC ACTGAATCCC ATAGGGATGA TCAGTAGGAT TTGCACCATT AACAACCCTC TAAGTTATAA TATTTTTAGT CATITTTTTC4 AACTGTGTAA TCAGCTGTCG AAACACTGTG A TGCCAAGATT TTACAGCGAG CAAGGGAGAG CACCTTTGCT TGGAAGAAAA TATCCTTI7CC ICCAGAGCAC CCTAACATAC TCTACCAGAT GACTCTT1TTA TATGTTrACA TATCATATCT rTCCAACAAA GACATTCATA TTGGCCTCAT GGAAGTTT TTCCATTCAG TTTACTCT TTTATTCTGG TTAACATCAT TGTAACATAA TTTGTTAATA ACAGCATTTA CAAGTTTTT TATTCAATGC AAGTAAAAAT AAGTGATTAA AUTGTGCATA CATGCATTTG CCTGTGGGCA CTCTAAACTC TGGATAATTA AGGGCAAAA GAAAGAAAGC [TAGAAAAGG AATTCTGAGA CTrCATTAGC CAACACTTTC GTCCTTGCCT GCTGGACTTT GAGTAGGAAA GGGAACACTG AGTCTTTTCA GTTGAAGGCC AGTGGTGATG GGTG17GCGG TTTCAGCCAT AAAGGCATCT GGCATAGTAG GCAAGAAGGG CCAGAGACCC GAGGAGAGTT ATCTGTCTCT GTTAACTTCA GTGTATCCCT CTAGTTCCCC AGATGCACCT

GTTTCTGTAA

TGTACCTTCT

CAGTGATGAT

CTAATGTAGC

AAGATGTTAA

CAATTTTTCT

GGACTTGACC

GCCAGAGTTT

ATATAAACAT GCATGTCATC AGAACACTTA ATATTCTGCA TACTGATCAT GACAACAAAA AACACAGACA CTCTCACTAG GATAGACCAT GTAGGAACAT CGAATTCTAT TCAGYTAGGA GTCTACATAT TATACCTCTG TCAAAACCTA CAGAATATAC AACACAGCAC AGAGTGAATr CTGTGGACAT TAATGAATAA TAATGTATCA ATATTGGCCC ATCAG'TGTA ACACTAATAT TAACAGGGGG AATTGAAGGG GTGGTGGGGA GATATGTTGG AACTCTTTGT GCTF7TCTGCT GTAAACTTAA AACCGCACAC ACAAAAAAAG TTATTTTAAT TTTTTAAAAA GTA~rCAGAG TT-FCCAAAT7 CTCTCAAAGC AGGTCGGAGT AGUTAAGAAC ACAAATTTTA GAACCAGACT GAATCCTGGC TACACCACT7 ACTAGCTTFTG AGATTTCAGA CAATfTACTT AACTTCTCTG TCTCATTTTC TTCATCTGTG TGATAAGAAA TAAAGTAACA GGCCAGGCCC AGTGGCTCAC GCCTGTAATC CCAGCACTT GAGAGGCCAA GGCGGGTGGA TCAGGAGTTC AAGATCAGCC TGGCCAACAT GACGAAAAAA TACAAAATCT CTACTAAAAA TACAAAAATT AGCTGGGTGT GGTGGCAGGC ACCTGTAATC CCAGCTACTC AGGAGGCTGA GGCAGGAGAA T-rGCTTGAAC GCAGGAGGTG GAGGTTGCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT CTAGGCAACA GAATGAGACT CCATCTCAAA ATTAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAATAT AGTACCAGCC CCTATCTCAG AGTTCCTAGC TITAGAAAAAT TCCCAGAATA TAATAAGTGC AATGTAAGGG TCAGCTATCT TCATrATUAT TATCTATCAT AAATGAAATT ACACAATAAA GCTAGATCCG MTITITCCT CTCCT-rCTAC AAAAAATAAA GCAACTTTFCC AGAACAATAC CCAGGTGATG ATTTCTCCCC TGCTCCCTCC CTAAGATATT GGCAAGTTTG GAGGGTTCAA GGAGAAACAG AGCATGTAGA GAAGATACCT CTCTCATAAC CATTTGTGAT TTACAAGTCT TACCTGATTC TTTTGAACTT AAAGGATGTA AGAAGGCTTT TGGTAGCTTC CATCTGAT7C AAGGCTTTGG CAGCTGCTGT GGAATACATG AGAACACTAG GTAAAGCACT GTCTTCCAAC ATGAAGAGAG AAAAATATGT GGAATGTTCA ATGGCATGCT TTGTATAAGA ATGCAACTTA CCTGGCAGGA ACAAATTTCT TTGCTGCAAA AGAAAAGACA AACAACCAT[ AATJ7CAGACT AAATGACTTr TAAGGATATA YfrAAATCCAG ATACAATATG ACTrAATrCA TCAAGTGTTG CAAACTCGAT GCT7CAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT CTGTGGCATC TAGGGTAAAA TGCAAAGTGC ACAGCCATCC AAAGGGCATA GCAGCTTCCT AATGCCAGCA AATAGCTACG GGGTCATCTT GCCCAATTCA GCTCCCAATT TTTCATGAGA AGTCCAAAGT CTTAATFAA ATGTGAGATT TCCTATTTFrG TAAACGTCAG AACTTAACTC AAAAATGTTT TAAGTACTCT TAAACATGTA AGCCAAACAA ACCATGAGTG TAGTCAGATG TGCTTCCATA TrCCTTATGA GAGACTCTCA AATTTAAGCC TGTACTCCAA ATAAATCTCC TrAGGAAGAA 1TfATCCAT TTCCTTAGA GTGCTCATCA TGGCAGTTCC ATTGCACAAT TCCGGGAGGC ATCATATAAT TCAACATGAA TAGCACCCCC TGGAGTrGTA CAATATI'AGG CACGACTAAC AYTTTTT CCTGAAACAC TJ7CCCACACT GAGTTGTACT ACTAACTCTT TTCTTrAATAC T-rCTGCTTAA TTATACTGCA TI=ATCCAG AYI7CTAATTA TTGTTTAAAT CAGTAAGCAA GACCATGACT TATCAATGAG AAAGAAATGT AT'FrTCAAAA ACA'FTrTTGA AGTACATTCA TAAACTTCCT CACCTYrTCCG TAAGCATT-rC CGAAGCCAGA GGAGAAATGG TGCTAATGTC AGGAGGGAGA GTCCAGCAGC AGAAAGTCCA GCTACCAAGG GAATGTTGGA CTCAGTGGGA GCTAAGGAAG TAAGAGACGA AGAAAGGTCA TGAGGAAGAA TTFGATGTTAA AGTCTCTCCG TCCTGTCCCT T-rGGCCT1I T-rCTGTACAT TCATTACTAG GAGCAGAAGA GCTATCTAGT TTAATACAAG AAGCAGAGAT GTGGCATTAC AGGCCTTTGA GATCTGCTCC AAGCCACCTT TGAAGCTATT TCCACCA3TG GCAGGCAGAA CTCTAACTrG CCAAGCTCGT TCACAATACC ACACCACACC TrGGTTAATA AACACTGCAC TTGCTTGCTC TCTTGCTCTC ACTCCCTCTT GTTTTCCATT TCCCCTFTCT CCTCTCCTCT CTCTGTCTCC TFITCCAGT TGTCAGAATT CTACCCTTTC CATCAACATG CAACTTCTGT TT1TTTCTCTA TCCCCATACA ACTTAATATT CACAAC117GT CAACCTGGGC GAACTCTG GTTTGGATAT AATGAATAGT TGATTACTGT AACAAGATAG CTCCCCCTITr TrCYTUTAA TCACCAGACA ACCACCATCA ATCAATGCAT CACCTTCACA GGTAGGTAGC AGGCCAGACC AGTGTCCTGT GGCTCCACAT GTCCGAGCTG CAGAGCCAT17 GAGCGTCCAT CCTTCAGGAC AGGCGAACTT GCACACAGTG CCAAACACGG GCTCCCCACT GCAGCTCATG TTGATC1TTTC CCGOAACTGC CAGGCTTGAA CATTTTACCA CTGCAAATGT TAGGTACACA GGCAGAGTTI' CAGAAAAATC TACTGGAAAA CTTCCAAAAC TTGCTTAAAA GTCAACAATG AATGTAAAGT GTAAGCGCTA CTJTAGTTTTC AGCATGTAGG AAATTAGGAC CAAACCCCY[ TGGGGCAATC TAGGTTCAGA AACTTTATGA AGTATTTGAC CTGTACCCTA AAAAAGTCTG CACTCAATTC TACCTTGGCA GGAAGGAACC TCTI7CTGTCC ATTGTCCCTG AGATGTGCAC TCAAGTIGAG TITGATCCATG TAATTCAAAT CCCTCCTCAC AGCTGAAGGC ACAAGAGGAC TTGTAGGTGA ATrCTCCAAT AGGGGAATGA GCACACCTCA CCAAACCCTT CGGGGGCTGG TGGACAGCAT CGCATCTCAC AGCTGGAACA CAGGAGAGAG CACUTTAGAA GTTTGTTTGC ATCTCCAGCA ATACGTTTCC CAAGGTAACC AAGTTCCCAA GCTCTFrCAAT AGTTCTTTrr7 ATCTTAAAAT AAAATAAAAA CAAAGACTGT ACCTTrCACAT GTGGGCTTCT CGTTGTCCCA CTCCCCTGTG GGGCCACATT GGAGCCTT-T GGATCccTTrC AACACAAAAC CCTGCTCACA GGAGAACTCA CAGCTGGACC CATAACGGAA ACTGCCAGAA GCACTAGGAA GACAATTCAT GTAGCCTCGC TCGGGGTTGG ACAAGGCTGT GCACTGGAAA GCTGAGACAT CAAAATGATG GTCAGAAAAT ATTGCAGTGG AACTAGAGAG TACTTGGCGT TTGTTGAGTG AACCCAGTTC ATITCAAGCAA CACTTGGAGA ACTGAAGATT CTTTATAATT CCCTGGACAA ATGGGAAGAT GGCTGTGTTT TCTTTGAATT TCAGCCCCCT CACTGATCAT GGCACTAATr AAAAGACTAA TTAATCAGAA CATTAGTTCC TGAGCACTGT TCTTCTAACA CACAAAATAA ATTATGGTCC AAGGAAAGAT YUCACGCAGT CTGAGGACAA CATATGGGTC ATGGATGYITT ATAGATGGTG CCAAAAAGAA AGAAAAGAAA GCACCCCTAT AAAATTTGTC TGTTTGCAG TTTGGTTF[T GTGTTATGTT TTGCTACTGG AAATCATTCT GTGCTGGCTT TGGCTAGGAC AAGGCCAGTG CCTGATAGTA AAAACTGCTT GT1TTCAATA TCCTTGCTCT CACTTTAAAG TGAA'FfAAAA TTTrACTGCTT ATATATOCAT CAATACTATC TCTGTAGCTG ACACCATGCT TGAAACAGTC TCATCACTGC TAATTATGAG CCATYITCAGA AGACAGGTGT GATGAGAGTT TfACATTCAA ATCATGTTCT CATTATTCTG C'rrTCCGAAT TTTCTAATAT GATTCCTTTA GATTAAGAAT TCTGTCTATT CCATGCTAAT GTCTACAAAG TrTTATCAGC ACATCACAGT TAAAAAAAAA CAGCAAAGAA TTCA'rrCTTA ACACATATGA TCC'I11TCCCT GGCCAAACAT TAGTTCTT[T AAATGAATCT CAAAGATACG AGGGTTGCTC ATCAAATCTG ATTTCTATAG TTAAAGTGGG TATTGGTTF TITTrTCACT GTCCAAGT-17 GAAGATGGTT GTTC~rTAAG AAAGTATAAA TCGAAGGATC TCAAGCTTAC C-17CACAAAC TGGGATTTGC TGTGTCCACT GCCCTTGAGT GGTGCAT"TCA ACCTGGGCTG GTCCCTGCAA CATGAAGCCT TCCTCACAGG TGAAGTTGCA GGATGATTTG AAGGTGAACT CTCCAGCAGG GGAATGGCTG CACCTCACAG AGCCATTCTG AGGCTGGCGG ACGGCCCTGC ATGTCACAGC TGTAACAAAT ATACGCATTG ATATTAGCAC GGCCTAGAAT TAGCTTGCCC ATTTCCAGTA TGGGTTGAGA GAAAGAATGT TCACAGTAAG TCTCCATGTG GAACAACTCT ACCTTTACAC GTYrGGCTTCT CGTTGTCCCA ATTCCCAGAT GAGGTACACT GAAGGCTCTG GGCTCCCAT~r AGTrCAAATC C1TCTTCACA GTCAAATGTA CAGGTTGTGT TCCATGGGAA GCTTCCAGGG YITTTGGAAAC ATTCCACGAA CCCATTGGCT GGATTTGTCA CAGCATCACA CTCAACCACT GAGGATTTTA AAGAGCACCA TGAATTAC AGAAGAATGA TCTTrTCACT TCCTATTGAG CTGGGTGCCT AACAGAGTGA GGAAGCTGCC TTrCAAAGGGT AGATCCCAAA GTCCTATGTC AATI7CTTAGG GACATOCACA GCCAGAATAA AAGCTfTTAT TCTTTTTCAT GGATATTCTA TCTTfTCTGA TTTCCAcTTr GCCTATGCTG AGTGGTCTCT AATCTATG'rr ATCATTTACG TACTGACATA CGTAGGCTAT GCCTCTGGTT CAGAAAGATA

TGAGGTAAAA

TCATTTATYr

AAATTAAGAG

ATTTAAAAAA

TAGCCCATCA

AATAGATTCC AGATTAGGAG TTATGACTAG G.AG3CCTU3AAG3 AACTGAIf-T TTC-TFT'FI AGAAAAAGAG ATACTAAGAC TGCTTGACTA TCATGGTCTT CAGGGAAACA AGATGAGAAA TCCATTGAGA T1TCTAGAGC AAGTTAGTCC CATGGCTTGG AAAAGTTAAA iTTATTGlTIT TATGGTCTCC CT-rACAAATC ACCAGAGCCT CAGAAACACC AAAACCTCTC TCAACCCAAG CAGGTACTGG GTTGGCAATA TACATTGGCT AAACAAAAAC AAAAAAAAAA CTTTCCCTGA AGTTGAAA ATGTAAGTTG GAGGGATGAG TTACAGAACG TrCTGTGCAT TCTCAGAGGG ATTrACCATT TCCATTCTCC AGAGGACATA CACTGCATGG TCTCCATGCT GCTTGGCAGG AGAGCAGGAA GAATTGTAGC TGAAGTTTCC CAGTGGGTGA CTGCAAACCA TCCAGGGCTG TACAGTJ7CAC AACTGAAAAA GAAACCCAAA TCAGTTCTGC ATAAGAACAC TGGAAACTAG AACTACAGTT TGGTTTTTT TITTTTTAGT TAATGGAATT TGTAAAATTG ACTGTAATTrC TACCCCT11TT CTrATrCA AACAACAACA AAAAAGCAGT GATGACAACC ATAAAAAAGA AATATTGAGT ATTGTG'ITTA CCTCAAAACT GT-rcAAATTA TATGAACAAA CACAGCAAAC CTTGTTACTT TTCTCACAAC TGCTAAAAAT ACTACAGTAA GCYITCCAACC CATfCAAGC ATAGAATAAA GAGAGAACAA ATTGTATTAA AATCAAAAAA CAGAAGCAAT GCAGGCTGGA ATAGGAGCAC

TAACCCCTAT

GGCT-rCCATG

TCATCTCTCA

T7AAAAAT[

AGAAAATGCT

GATATGGGGA

TTAGGTACCA

AGGATGAGAA

TAATGCTGCA

AATCAAATAA

TGGCTCATAG

ACGCTGTGCT

AGCTATATTT

TAGTAGCCAC

TCAG11TCCTC

GAAAACACAG

GGAGAGAAGC

TGCTCCATGC

GTAACTCACT

ACACAGAATT

ACACTATTAT

AAAATAAATA

ACCATATGAC

CAAATTTAAG TACTAGAATA TATCTGTGTG GCTACTCAAA AGTGTCACCA GCCACAYITrC CTATGGAACA TTTCCATlAT

CATTACAAAT

T~rTAAACITG

AAGTACTCAA

CACAAAAGCT

TTrAAAACCC

AATTCGTTGA

TAACCACATG

CTACTGCACA

CACAGCTGAT

CTCAGGGGAT

CCTITAACAG

ATAAAATTTC

GATCCATAAC

GAGTAGTGTA

CAACAAATTT

CCATTCACAA

CTGTCTACTA

CATT-fAAAAT

GTACACACTG

AAGGAATCTT

TCAAGTGACT

CCTGGACTCT

CCTCGCAGGG

TATGAAGTTC

TCAAGGTGCC

GCTCACGATC

CTAGGACGTG

TCATCTAACT CTCTTAATGT ACAAATTTAG GAACTGAGAC CTCATrCAT TACACGGCTA GTCATTACAG AGCCAGAGGC CAGAGCATGA ACCAAGATAC CATTTCTACT GCAACGTCT17 GTTACCACCT AGATGAGGTG AGTACATGTT ACAG1T1ATT GAATGTGTCC TGTGTGCCAG GCACCATGTA ACCATGAGCC TATCCTCATF TTACAATGAG AAAACTGACA TAGAGAGTTA AACTATCTTG ACTGGTGAAT CTAGGACTCA AACCCAGCAG GGTCTGACTT CATAGTCTCA ACCATCTGCA CCAGGGAAGG GAAGGCATGC AGACCTGACT CTAATGCCAG AGATGGTGCT ACCATGTCAA TGAAGCCAGG GTCACACTTG TGTATTGGTA CAGGCAGCTA TGCC'T[TGAT TTTAGAATCA ACTGAAGTGT TT-rACAAAGT TAGCTGTGGC TGGCACCTAC AATAAACAAG TAATFAAAAT GTGAAGAAAG AGGCAAGAAC CAGACTTACT TTGCTCACAC TTGAGTCCAC CAGTATTTAT ATATATTTTA TAAAATGTAT ATAAATGCTG GTGTGTGTGT ATATATATAC CTTTAGCAGT TAAACAGAAT AATTTGCCAA GATGCCCACA AGGGCAAGCT TCTTCTTGCT TCTCCACGCA GTCCTCATCT CAGAGGTTTC TGGGTTCCTA.

GGTGAATAGC TCAATATGGA ACCTTTGCTG ACAATAAGCA TCCACTCTCT TTAATGAGAA GTTTAACTCT GACAACTGTG CTCATC11TTT CAAAAGTAAG CACCCACTAG GTACCTTATC TCAGAATAAC TAAGCTTTAT CCATGCTATT GAATCCTCAC AGGGAGACAC CAAGAGGTAA

CAAGTGTAAT

CGGAAAATAC

ACAGTGTGCA

TCCAAATCTG

CGTAGAAAAT

ATGTATTGTG

TATATATACA

TAGGCTATAT

ATATCCACAT

CTMIGGAAC

CACTGAAACT

GCACCTCTCA

T1TTTGCCTAT

CCCAGACCCA

GTTTAGGTAC

CTGGCCTCAT

ACAGAGACAT CAGCAGTCCT ACAGAGTGCC AGTITCAGGC CCACCTATCC TAAACCTTGA TTACTTCYFC ACAAACTCTG AAGACAGTTC TGTGTGCATT TrTATATGTA AAGAACTACA TACACACATA TATGTGTGTA TATGTGTGTA ATATATACAC ACACACATAT ATGTGTGTGT ATTCTTGCCC ACAT-rCACAC AAAACAGCAA ATAAAATGAC CACAATAGAG AGCAGTTT1T ACCTCCCACT GCTGCCGCAA ACTCCCTACC TCATTCCACA TGCCCACATC TrTTCTCTC TGTTGGGTTC ACCTGGAGCC CAGTITCTTGG CACATTFGTTG ACTTTTCTGA TTCCAATCCA TCAATCTCTT CTTTGTTTTG AATTGCAACC CATAAGTCAT AGCTTCCGTG GAGGTGTTGT GAGAAAAAGA AAAGAAATGG TAGAGTTTGG

ATAGACTTTA

TGCTAATGTA

CCCTACCACA

TATTTGCCTA

TGTATATATA

OTATATATGT

AAGAGAGAAA

GCATGCTGTA

TGTGTAGCAT

TTGATGTAGA

CTTCTTCTGT

GTAATAACTT

AGGTGTGTGT

AAGACCAGGC

TACTGTTGTG

TATTGATGGT

AAAGCATGAT

CTCTACAGAT TCACCGTGGC CACTOCAGGA GAGGAGGACT ATTACTGTGC TTATACTGAG

GCACTAGTGG

CTTTTTATTG

AAGTACGTAT

CACACTCACT

TGAGCACTTA

AATGCATCTG

AGTAAATGAC

GCAGGACAGC

GTCTAATGGC

CTTTTCACCC

TCTTATTrTTT GGCAATGTTT GTGACATGGC CCAGACTrTT GAAGAAACAG CGACUTATTG 'TrATCTCYJ7 TTGTGACTGC CACAACATTA TAGTATACCC GTATGCACCA AGAAGCACTG GGAAATAGGT CATITATGATC CCCAAGCCCA GGGAAGAACA CCCAGACAAG CAAGGATATT GATGCTGCCA

TGCGAGAATG

CAATCATGAC

ACAAAATGAA

TCCTAAGAT-r

AATTTTAAGA

TACAGATGTG

GCGTTCTGCA

CCTCTGTCTC

GAGGCCCfTT

AAATCCCCAA

ACTCTGTCTC

CAAAAATGCA

TTAGTAGTGT

'I17GTCATCCA

TCTTCCTTTT

AGATATTAAT

CACTCAAATG

AAGTTTCATG

ACCACTTTGG

GATATCCTGT

AGAAATCTTG

TTCAAGAGTT

ACTGACTTAC

AAAGGTTTAG

UTAAAGAAGG AAATCGTGGG TAGCTAGTTA TTGGGCAAAG GACACTAGTG CAATAATCTT CTTTCATTAT TTAGGTCAAA GAGAAAAGAC GTrTTTATTA GAAGGCCYITr TGCATATCTG CTTACCGUTT TGGGAAGCAG YITGTTCAAAC AGGTCAGTAT AGGAGTTTTG ATGTGAAGTC TATAGGAGGG A'ITGCTTCCT GTGAATAATA TGGCATCCAA AAACTTTCCC GGGAATATCC TYfGAAGCTAC TTCACC'rrfG TCCATGCCTT TGATTFTAA TrATAATAAC ATAAAGTCTA CTCTCATGTA GTTGTGGTAG TAATTAGAAT TAGTCTACTA CCTTCAAT CTCATTCATA TCACCTGCCA ATrCAACATA TTTAACATGC CTTCAGATYJ7 TGCACGGCAG TTATGCCTAA GTTAAAATAA TGCCT-rATTT TAAAAAAAGA GTTTGTTCAG TGAAAAAAAT AAAAAGGAGG GAGGCCGAGG CAGGCGGATC ACCTGAGGCC

CCAAAGTGAG

GCTTGAAATA

CATrATTCTA

TATTTFCAGAG

AGGTT-17AGC TGTTf-CATGG

ACAGGATCTC

AGCCAAGAAC

GGAGGATATTr

ACGATGCTTA

TATATCGTAT

TGTCTTTAAA

ATTTTGTAGT

TATGAGGTAC

CACACTITTAC

CATTGCAGGT

TCAGTCTGAA

AGCTGAGAGA

CTTTCCTGGG

CCATGATGTT

TTTAATCAAA

TACAATACAA

CCCGAGGCTG

TCAGGTGGGT

AGCTGAACAC

GTCCACATCC

AAATTACAAT

ATGCAATT-

AAGTTGTAAA

AGAATAATAA

TTTCCATGAA

ACTTAAGGAA

AGAGGTCAAG

ATATCTATAG

AACTGTGAAG

GAGATAAAAC

TAAGGCAGCA

TAAATAAACA

TAAGAGCTTG

CCCTT7ATAAA

ATCACTGCTG

TAC31TCGGCT

AGTAAAGAGG

GATGTCAGAA

AYITAATATGA

ACTTTGCTTG

TTCAGAAACA GAAGGAAACC AAGAATAGGT GCTGTGGATA ACCAATCACT ACTCATTTTT ACTGTCTCAC AGAGGAATGA CTCACAAGGT ATJTAAAATAT TATCTAAAAA TAATATCTAA AAAATGGGAA ATAGATATTT ACATCTGGGA CCAGGCACAG TGGCTCACGC CTGTAATCCC GGGAGTTCAA GACCAGCCTG ACCAACATGG ATGGTGGCGC ATGCCTGTAA TCCCAGCTAC TGGAGGTTGC AGTGAGCCAA GATCACGCCA AGAAACGCCA TCTCTACTAA AAATACAAAA TTAGCTGGGC TCGGGAGGCT GAGGCAGGAG AATCGCTTGA ACCCGGGAAG GTGCACTCCA GCCTGGGAAA CGAGTGAAAC TCTGTCTTAA AAAAAAAAAA AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT ATATATATAT A'FrrAATTGG TCAAAATT GTT[AAAATT TTTGAAATGT TAATGTGCAA AGAATAAAAA YrCTTCCACA ATGTTAACAG TGACTAACTC TGGATGGCAG GATTTGGGAT AATTrTTATA TCCTTCATTA TTATTTTCAG GAYITTAAAG TrTT=TCAA 'rTrCCCTITT T-rTCACC~rT ATAGTAACAA GAATACAGTT TAAAGAAACT TGTCTCTAGG CCAGGCATGA TGGCTCATGC CTGTAATCCC AGCACTTTGG GAGGCTGAGG TGGGTGGATC ACCTGAGGTC AGGAGTTCCA GACCAGCGTG GCCAATATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ATTAGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGGAGC CTGATGCAAG AGAATCGCTT GAACCCAGGA GGCAGAGGTT GCAGTGAGCT GAAATCACAC CATTGCACTC CAGCCTGGGC GACAGAGCAA GACTCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAAAG AAAAGAAATr TGTTTCCAAA TGCAACAGAA GGAGATGTAT GTGOTATCCT ATATTCCTGC TCTITCATTT GACATfTCTT CTGGGTGATT GTATACATTC CCCATCTCTG CATCTTACCC TATCTAAATG ATGGTAACAG TAAATGGGGA TCATrTTAAT TrrCCATATTC TGTAGGTT CAGAGCTCAA GTCAAGCTAA TATTCTATAT CTACAGCCUT TCAAAATAGG AGGTCTATCT AAAAATGTAC TGTCAGCAGA CCTGAACGAG TAGTGGTAAA.

AGCCTCGTTTr TTCTCTTTAC 'rrGTTAGCAC TGGTCTTTCT GTGTTCATAA AGATGTCAAG ACCCAAAAAA AAAACAAGAA AAGAGAAGAA AAATTCCAAA AAAGACAACT GATTAGAAAA AAATAACUTA ATTAACGAAT TTAATTCAAC CCCTATCAAA AAGCATAGAA T-IfATTCCCT CCACC'ITACC ACTCTCTTAC ATGATCCAGA TACTGACAT"T ATTCCAATTC TTTATCCCAC TTTACTTAGC TCAATGTGGT TGTTGCTTCA ATAAATTCAG AAGAGTAATC ACTCATATAG TGTATTTA GATTAGGG CAGAATGTCA AGTTGGGTTA ATACATTATC TGTATGTA'rr T-rATTTAA TAAAGTATGA ATACATAATC TGCTATITI AAAAAGCATG GTCAAATGTA TAGAGTAGCC AAATCTTAAA AAACAATTrA TCTT1CGATAT CAATAAAGTA CCTAATAATr ATATTGCTAA TAGAAATTAG TCGTTAACAT CCCTAGATAA CTAACTTrAT TATTGCGAAT 1TTTCATA AC TAAGT-17ATA GTTrATCTCT TCCCCYTrTT AAAATTAGTT CAAAGATATC TAAAAATAGC CCCAGTGGTG ATGAAGTrC TATTTTACTT ACATATATAT TGCCAGGCCA TAT-rCTGAGC ATAGGTACTC CTATfATCCC AGCACAGAGC TAAGGGTTGA CATGATTTCT TTJ7GTTGTTA CTTCTTCCTG AGACATCC'Fr GGGGGCTGGA AGGGACCCCA CCGGTGCATA GGCAGGGAGA GTCCTGGACC CCCAATTATA A'FITrGTATG TTCACCTATT CATTACAG ATGAGGAAAT AACCAGGCAG TTGATATCCA

AAGTTGATCC

CAAACTGATT

TUCGAAGGAT

TAATATATAA

TYrATATATAT

ATTTTATATA

AATAGAATCT

AACTGCCTTC

GTACTGAGCA

TGAGTGTUAC

TCCCCTCCTG

CACAGATCCT

TTCAGTTACT

GTTTTAACCA

TCTGTGTCCC

TCTGGCTACC

AGCGCTGCGT

CTAAGCCACA

ATTCTAAATT

AAGAGAAATG

TATATGTAGA

TTATATATT

TAAATATAGA

TGAGACCTCA

CT-ITTGTTCC

TGAGATCCAT

AGAGCCTTGC

TGCCCCGAGA

GACCATCACA

GGGACAGTGA

AAGTGGACAA

GTTCCCAGAA

CTAAACTGAT

AGGAGTGGAA

GTATATATAT

TATATATATA

TATTTTTATA

AATTCACTAT

CAAATACCTG

GCATAAT17C

TTCCTTGTTC

GCTCTCCACT

GCAGTAGGGA

AGGAAAAAAC

GTTCCTGATT

TATTFCTAAA

GAGATAGGT(

ATAATTACAA

GATATTTTTA

TATATTATAT

GCCAAAGGGA

TAAT[CACA

CCTCTAGTCC

ATCTCTAACA TTTATTGAGT GCTTACTATG GATrFATrCAA TCCGTACAAC AGCCTATGAA TGAGAATCTG GGGATTTTAT CTCATTCAAA GAGCCCACTC CC'ITACCTGC TACTCCAAAC TACCCAAGTT TCCTGTACTC TTCTTGCCCT GAGATAACTG TGTCCTGGGT TCTGAGACAT GAGGATOCAG TGAGAACAGA CCCTGGATCC AAGCAAGGCA GGTGGAGCCA TGCCTAGGTA CAAAAGCAAA TTTCTCTAA GGTCAAAGGG TTGAGAAAGC TTCAGGGAGA GATCCCAATA AGTAACAGTA ACT17AAATGT AGACTATATA TATATTATAT ATGTGGAATA TATATATTAT TATTTTATAT ATAAATATAG ATATiTTTTAT

ATAAATATAT

AAGTTAAGCT

TGCTTrACT CTTCTTTT7A GTAAAATACT GTGAAAGAAG TGGGAAATGA GTCATGCAAA ATCTTATATA AAATGTAGAT CATGTAAAGT GTAGACTCAC CACAATGTAA ACACTTGTCT CAT"rGCCAAC CCATCTTTCG TTTA'TrTCT CTTGCTCT CCCCTCTAAA GATGGAAGTT CCCAAAACTC TCTTTGGAAA ACAGTGATTT GTGTTTCTTT TACCTGGGAC AAAATAAACC TCTAATCTGT TTGGTTTA CAATATGTAC ATGTATGTAT ATAATTTATA TGTATATAAT GAGGTATGU7 ATJ7CAAAATC CAYFCATCCT TACAATTACC TGCATTCTCC TGCCCCCGAG GTJTGTCACTG CAAATCAGGT ACATGGATAC TGGGAGCTGA TGGGCTGCTG AAGGGGCCAT AGACAGACCC AGCTTTCCTC TCGTGGAGAG GGGAGTGGGA TrACAACCAG ACTATAGCTT CTTCACCTGC YI'TTrCCTAT

AAGCGCAGGT

TGAGATATGC

ATATGTACTT

CACAGTATTTr

TGGGCTCCCC

GCCCTGGGCC

CAGGATTTCA

TTGGGTAAGA

ATATACCCCC

GTAGCTAGCT

TAAGAGGCAA TTGCTTGTTT TTTGAGGGTG GGGGCAAATC AGGGGGAGTT GAAGAGGAAA TTTGAATAGT TGGGCATGTT GAATA117ATG AATATCATCT CCCTCTTCAA ATAATCCAAA AAGAAACAGG CTGATrAGAG GTGCTTCAAG GCTCCACTGA ATCTCCCAAG CTCTGAAGAT GTTACCGGAT TGCCGGTTTT CAAGCCTCGC CATCCGCTAC ATAGATGGGA ATGAAAAGAG CCACCAGTGC TAITTTAATCT CTGAGGTGTC TCCTCTCCTC CACACCCTrr AATCAGGCAT CATTCTCACT TTTATGGCAA AGGGAGTGGG AGACAAATGT TAGAATTTTA ACCAAGGCCA ACTGGCCACA ACCACACGTG GCAAAAGCAT AAGCAGGGGC AGTGGTGTCC TCCTGCCTTC TACCCCTGAG TGCTI7AGTTT TGAAAGCCTT TCTAAGTTAC C1TFGCAGAG TC317AGGTAG ATACAAACAT GGTATTI7CTT GCATTCCCAA CATTT'FrTGT TTGATCAAAA CCTAAATATA AAGCCATGTT TACTCACTTG GAATFrTATAG TACCTCACTC TrCTCCCA CACCCAGGGG CTCACATGGA CCCTCTTGGC AGTTTCTCGC ATGGGGGAAG

GAAAGAAGAC

ACCCTTFCCTG

CAAAGACTTr

AGACAGAGAG

CCCTGTGGAC

CTATCGAGGA

CTGAGGCACT

AGTTCCCTCT

AGGGAGGAAA

GGTGCAAACT

GCTTrATTGT

AACCAGTTTT

ATAGCCAGAA

AGGAGATTAT

GTGAAGTTAT

CTGTTCCCTTF

CTCCCATAAA

TCCCAATAAA

CCTGGACAAC

TGGCGCCCAA

GATCCTATCA

G11TGGTGCTC

CTGGAAGGCC

GAATTCTTAC

GCTAAAGAAT

AATTCCACTA

TATTTGGCAG

TCTTCAAAAT

AAGAGAACTT

GGATTT-rAGA

CCTGAAGGAC

TCACCTAAAA

GAATTTGGGC

CACTTAGATG

AGCTATAGGT

AGAACCCCAC

ACATGGAAAG

TAACACAAAT

ATJTCTFG

CATCTTATCT

GAGCAAACTC

TTCCTGAATG

AGAGCCCCTT

TAYJ7AT17AGC

TGCACATCTT

TTTAAATGAG

TATTGGCCTA

ACCAGAATTT

TTrGTAAAGTG

TAAATGTATA

ATGTATATAI

AGCTTCCAGG

TGAAGTTTCC

TGGTGAATTC

TAGCCAGACT

GTTTGTTTTC

MrGTTCTCA AAUGTGAAA GAAAATGTGT TYI7GATGAAA ATGTGTCTGG ACATCTTATA ATATCTGAGT GAAGTGTAGG GTTCTCAGAC CAGGTCTCAT ACTCAGAGGC TATCTCAGAT GATrrCTAATA GGGCCACCTA ACTTGGAGAA TGATCAAAAT TTACTATCAT CTGGGAAAAT ACAAGGAAAA AGAATTCT7A CCAATAAAAA TAGTTATTCT CTTTTCTCCT ATGATCTGAG ACTTGAATTT CAGGCACACC CCGGTGTCTG CTCTrCCTGG AAGTCTCTTG GCTGTGTGCC CAGGCCCACT AGAAGAGATT GGGGACCCCA TGGGTTTAGT GGAAAGCAGC ATTTGGTGAA TGTGACCGGG ACCTCTGCGA AGGCTTATTT AAAGCTCTAC TCTGCTAACA GAYJ7CCACCC TATCTGCAAA ATCACCACAG TAGAGAATGG TTCTAAGTTT ATTTCCCAGA CGAGTAGGAG CTCCGGGCTC TTrAGAATAA AGAGGAATCA TCTGACTCAA CAGGTCTGGG CAGAATGTGT AAGATGACCA AATGTTAGTA AGACCCCGTG TGTGACACTT CTCTTCGGAA TTTAGGGTGA GTAGCATTT AAAAGCAAGA GAGAATAGCT CTGAYJTCCAG AGGACTrGT TTCATGTGCT TTTTGCYJ7CC

GCTTTCTGCT

CCAAAGCGGA

GMrGCCGAC C'FrGGCCATr

CGTCAGAAAA

TGGGGACCTA AAAACTAACT AGAAACAAGT GAGGATCGGG TGTT'TAAC ATGAGGGAAG TGTGCTGCTT GTTTTGTAAG CTTCTGCTCT GGCCACTTTT

AATGGGAATT

CTGGTTAATT

AAATACCCCT

TCAGAAATTT

AAACATATAA

CTTGGATTTT ACTGTATTAG AAAATGTAAC AATTACAGAC AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC TTTIT[CT TCCCCAAATC TAAAATAGGT GAT1TTTGGAG AAGTAGGAGA AAAACCTGGA TrTCTAGAT TTrGGATTAAC

ATCCCAGCAT

CATGGTGAAA

GCAACTCGGG

CGCCATTGCA

ATU-AACACA

AGTCTCAGAT

CTCTrAGAG CTCAACAACT GATATAG17A CGGATAACAA TGAATATTTA AATACAGTGA TTGGGGAGGC TGAGGCGGGT GGATCACCTA CCCCATCTCT ACTAAAAATA CAAAATTAGC AGGCTGAGGC AGGAGAATTG CTTGAACCCG CTCCAGCCTG GGCAACAAGA GCGAAATTCC AGAGAMIICT ATfTCACACT AATGAGCTCT TTCCCGAGAG CTTATTrTATT TATACCAAGA

ATTATGTAAG

TT-rGGCCAGG

AGGCCGGGAG

CAGGCGTGGT

GGAGGCAGAG

ATCTCAATAA

GTCACTGGGG

GTGC'FrTACT TCT-17GATAT TTGGAAATGA AGCAGTGGjCT CATGCCTGTA TTCCAGACCA GCCTGGCCAA GGTGCAAGAC TGTAATCCCA GTTGCAGTGA GCCAAGATCA ATAAATAAAT AAATACAGTG CAAGCTTCTT TGCCTCATTA ACCGTCTCTG CTAGCTGTGA CATAATATGA CAAAAGGTAT AAATATGGGA AAAGGCACTA AITITATATCA AAGCGTTCTT~ CGTTITFCCT TGCTGTGAAG TTrTTAGCTA GGCACTrCAC ATACATTGCT GGACAAGATA GAGATCTGGA AGATTCAATC TGTGTTACTC CAGCAGGGAA GTAAACCTTA CATCCCAGTf TCACGAGCTr GGTGCCAGTC ATTTATTGAA AAGGAAGAAA CTCCACAAGA CACTAACAAA CTCTGTCTAG GTATATATCC GCCAACTCAG TTCAAGTGGA TTCCTGTGGT ATGATCTGAA TGCTGTGTTG CAAACCTGAT GGCTGCAAAC CTCAACTAGT TTCTCTGCTC GGAGGCTTGG GGATGAATCC AGGACCAAGG TCCCTGTTGC ACTCTCTGAC TCGTGTCTCC TCTCCAACTG TGCCTTCACC TOGGATTACA TTGGATTrAT ATTCCATCTA CAAAGTCCCT CAAGACTGGG CAATTCACAA ACAATCATGG CAGAAGTCAA CTTGTGCAGG GAACTCCTCT ATGGGAAAGT C17GCCCCCA ATGAGATTTG TGTGGGGACA GAGCAGAAAT CTTCAGGAGT ATAATTCATA AGAATATACC ATATrTAGAG TGYFITACTAT GCATGGGCCT TCTTACAAAT TTTACAAAGT GAAAGGTAGA TATrAATCTC A1TrATGGA GAGGTTACAT AACTTGCCAG TGTTTTTTCA GTTAATAAAT GGTAGGGTGG TAAAGTCCGT GTCCTTTTA TTGGCTCCAT GCCTACTCAG ATTrAAATCT GTTTTTACAT GAGAAAATGT TACAGCAGCC TTCTCGGCTTF CCYITACCCC AGTGCCTTAG ATCGGGTTCC TTTAGAAGCA GACCTCGAAA TAAGGATGTG kAGATGATCC CAAGAAAGCC TAGTAGGAGA GTGAGGAAGT GAGATGGGGA

AGTGTGTTAA

rACAGAAAAC

TCACTGGCTG

CAGAAAAAGC

GGACAGGGTG

AACACATATT

TAGGTTTCAC

ACTTTCAAGC

CTUFGCTGGCT

ACTTCACCT-r TCA'TrCTCC

TCAATCCAGG

TCCAATAGTA

TAAGCAGGTT ACCGCTGTGG CTCAGGGTCT CCCCAAGGAG

AGAGCTGATC

CCTCTACAAT

GGCGTTATTA

TATTATGTCA

ATTGCCAATA

TCATTCAGAT

GTJ7GGCCAGG

TCAAACCAGC

TCTGTGTACC

ATAATCTCCA

CTGTATTAGT

CTGGGAGGGC

GAATTCCAGA

G1TTTCTGTC

TAGTTTGTGT

TCAAGGTGTC

TGT-FGGCAGA

AGTCATTCTT

AGCGGCTAGT

ATGTCTGCCT

TATTTTAAGG

CCATTTTCAT

GCAGCCATGG

GGGCAAGAAG

ATGGTTAAY[T

TGCTrGTATT

ATTACTGTAA

GGGTCAGAAG

ATCCAGTTGG

ATCCAGTTCC

AGCTTCTAGA

CGAGTCCCTC

CTACTGCTTG

CTAGCTGACT

GCTACTGATA

CACATGGCTG

CAGCAGGCAA

TTCACTATCA

ACAACATGCA

TGTTTGATTA

GGCTGGGCGC

AAGAGATCGA

GGTGGTGGGC

GAGGTTGCAG

AAAAGAATTC

GGCTCAGCTG

TCTGCCTAGG

CCTCTGCACT

TAAATCTGAC

CAGATTACTA

TACAGGTTAG

GCTCTTCTTG

T-FGTGGTTGC

GACTACCTGT

TCTTCAAATG

TAAGGGCTCA

AGTGATCTTA

AAGACATACC

GGGAAGCCTC

AGAGAGAGAG

CAAGAACAGC

GGAATTCAAG

AACAACCAGG

GGTGGCTCAC

GACCACCCTG

ACCTGTAGTC

TGAGCCAAGA

TGCCCATCAT

AAGAAAGAGG TTTAATTAGA TTTACAGTTC

GGAAGAGCAA

TTTTAAAACC

TGATTCAATf

CAGCCAAACC

GGGGGGCATC

GTCATGTCTT ACATAGATGG

ATCAGATCTC

ACTCCCACCA

ATATCAAGTA

TTTAGAATTC

GGTGGGTGGA

TACAAAAATT

ATAATACTTA

GGTCCCTCCC

CCTAGAT[CA

TGCCCACCAA

TCATGAGGTC

AGCCAGGTAT

CCAGGAAGCG

GTCTCAAAAA

ACCTGTAATC CCAGCACT~r GGGAGGCCAA GCCATGGTGA AACCCCATTT CTACTAAAAA

CCAGCTACTC

'FJ7GCGCCGCT

AGTAGGCTGT

GTTTTCTGAC

TAGAGT1TA GGCA'FrTATC

CTGATGTCCC

AGTTATCATT

ATCATAATAT

AAATAACTTG

CCAAAGTCTA

CACTCTACTA

AATGCAAAAT

TTTTACTATT

GATGCCTTCT

TAAATGATCA

GTCCTAATCG

ATTTCTCACA

CTGAGCACAG

GTCCTGGGGG

GAGACYITAAA

AGGAAGCACT

GCTATCTCGG

CTGGGACAAC

TGT-rGGCCAG

ATTACAGGCA

AGGAGGCTGA GGTAGGAGAA TCACTTGAAC GCACTCCAGC CTGGGAGACA GAGCAAGACT CCTACAGAGA CATAACCCAG GAATTAGGTG AATGGCTAAC CTAAATTAGC ACTGTGATGT TTGGTCCTTA TAGCTCCTCT GCTTAGATGT GGAACTAATC CATGAATGCA AGTGGGAGTT AAATATCCAA AGTACAGGAG ATATTATGGG TGCCTCATCC 1TCTTGGAT AACCCAACTC TATTAGTrUT TATATCTCAC TTGTTCCTAT ATAAATAGAC ATTTCATT GCCAGTCTTC TTGAACAATA ATTACGATTA AATTGGCCAC TTCACATTAG ACACAGCACT TAGGACTTAA GAATACCATG GGTCAGGAAT TAAGTATTGC TATCCAAATT TTACAAAGAA GGCACTGAGG CTTAAGATGT CATAGCCTGT AAGTGACAAA ACTAGGACTC AAATACAGGT TGTTCTTGGC TACCACACTG CCTCTCCTAC AAGTGACCTG TGGTTTTACT

AGGGTTTGTC

ATGTCCCCT[F

ACTCTGTGAA

TTAATCTAGC

TCAT'FrGATC

GTTAGAGTTT

CCATCTGACT

ACTATATTCA

ACT-rTACCAT CTCCCATGAG TCTGTCTAGA GGAGGGCACA CACAGGACAG AAAACACATG AAGGAAGGGC CTACTTACTA

AATTAGTTGC

TCTCATAGGG

AAAATACCTG

TGGATTTCAG

ATATAAAAAA

ATATGGAGAA

TCAGACCCGA

TAAATATTAT

TCTTfTTT

CTCACTGCAA

AGGTGTGTGC

GCTGATCTCG

TGAGCCACTG

TGGTGCCCAA

TATTTTA1Tr T-rGAATGAAT

GATAGTAAGC

AGAAAAGCAT

GCTAAGGGAG

CACAGAGCCA TTCTAATACC GTT1TACTG AGAAATGGGG G17GTTGTAT CTCCAGGCCC AAATGGAGTC ACCTGAAACA ATCCTAAAAG GAAAGCATGC CTGAAAAAAG CTGCCAGCCG AGGGATGATG GGCCATGCCT

GGAGAGCAGG

ATACACAGTT

TTTGTTTGAG

TCTCTGCCTC

CATTACACCT

AACTCCTGAC

CACTCACCAA

AGTAAATTGA

AAGTGTCTTT TGAGGGATAC CAACTGTYFT TATGTGTAAA ACAGAGTCTC GCTCTGTCTC CTGGATTCAA GTGATTCTCC GGCTAATTTT TGTATITTTA CTCAGGTGIT CTGCCCGCCT GCACTTCTAC TGATAGCATT GCCT7CCCAA CTAATACTAG AAGCCAATGA GGCCACCTAG CAGCCACCCC GGCATGGCCT GATAAAGGAG TCAAGGTAGT AAGGTTTATG TAAAGCAAGC TGATGTrGC TCTAATCCAG ATAATI1TTGG AAGTCATAAT CAACACAGCC TGGCTTAG TGTTAAACAT TTGTITCATGT ACACTGTTCT TGCTACATTA CTGTGTCTCC TAATATCAAA CTAACCTCAT CATGGCAAAA ATITFCCACAG TGGAAATAAT GGTAGTAGGT TTTCACAGTA CCAGCCTGGA GTACAGTGGT TGCCTCAGCC TCCCGAGTAG GCAGAGATGC GGTTI7CACCA CTGCCTCCCA ATGTGCTGGG TACAAACCCT TCTrAGAATA GAGGTTATAA CCTTCATACC AAGGAAGACT GGGCATTGGG GTATGAGTGG ATGAGGGTGA CAGCTGCATC TCTTTCACCT ATCAAAGATG ATGAAATGAT TI1'TAAAAATT CTAAGAGAAG

AAAACTGGAC

CCCAGTGAGT

CTrrGTCCACA

GTTTGCCAAT

CAACCTGACA

AACAGAAM~

TGTTGAACAA

ACCGGAATAC

AATGCTTGCA CAAAAGAAGG CCTGGAAACC TCATCTGTGC GACAATAGCC ATCTAGCTGT GTTACACAGG YFGAAAAGCT ATGAGTACTA TGCTGCAT7G CCTCACTCTC TGGATGTTGG TGTTGATTTT GGAGAGAAAA AGAGGATAAT TTCAGCAAGC

TCCAGAAAGG

CTrACT-rGGC

CAGAGTTGAA

CAGCAAGGCC

CTCAGCTTTA

AAGTCTTTAT

AATGAAACAC

TTGTGGAGCA

AACTGTGGAA GATTGGGC TGAATrrCAA CTTTGATGTT CAGAGGTGGT GCCTTTGTGT AAACCCACAA GTCATTCCCT GGGGAGTATT TCATCTCTGC 'ITCTAATAGA TAGGAAGAAA TCGCCU7ATC TCATAGAAAG ATGCCTCCAG CTGTGATTCT AACAAGTGGA ATGT-rTCCCT 1TTCTCCGAT ATGAGTGGGC TGTAACCCCT GTCAGGAATG AGTCACTTGC CTCCCTGGAA GGAAGAGAGG AACAATACTr MTTAAGAAG TCTGTCTGGC TAAAGGTAAT TGGCATGGGA TCATTAAGAG AGCCTTGTCT GGCTTGGGGA GCTACTAAAT ACTCAGAAGA AATAAGGCGG TATTCAGAAA ACTGAATCAA AAGTACATTC TTCTGGGTTr TCTTAGTCTA TTGTTAAATT TCTGGGAAAC AGCATAGAAT GGGAGAAAAA ACTGGTCACT

AACAAACAAA

GAATTTCAGG

TAGCTTTAAA

ATAGCAGCAT

GCTGCTAGTG

CTCAAGCCTA

CTTGGGAAAT

TCTAGAGGCT

AAATGGATTC

CATGGAACAC

CCATTATGTG

AGAGCAGAAA

cTfrACAACAC

GGGCATACTT

TAAACTATAT

GGTTTTATGA

TTTTTACTAT

TTAAGGCTGT

TTrCACTTTCT

TTTGTTTGAT

GCTAATGATC

GTCTGCTGAC

ccTTrcCTGTC TAGAAT'FrTC

TTAGAAATCC

AACCACTTTC

ATTCAGTTAC

ITFCTCCGCT

GTTGATGTTG

YTMCAGAAG

TTIATAAAATG

CACAGTCATA

ACTGGATTAC

AAAGTGACTC

CCTCATACAT

AAAYT1TTTTT

AGTGCTGTCA

GGGCCTTAGG

ACAGAGTCTT

CTAGGTTCAC

GGCTAATTTrf

CTCGTGATCC

CTrCAACTTA

CCAGGCATCA

TATGCCCTAA

TTACCACAGT

TCTAACCTCA

TCACAGAATT

TJTCTATCCAG

GATAGCACTT

CTAGAT]TA

AAAGTAAGAT

GGACAGGCAG

GCCATTAGAA

AGGCCTGAGT

GTTrATCACC

TCGCAGATCA

CACACAGACA

CACAAATACT

ATAATCAAGA

CACTTACCT'r

TCATGTCCAT

TGTFrGCTATA AAAGTCTGGG TATTGCTGCT TTCTTCATCT G17'AAATAGC AAATAAAATA AAATGGATGA AACTAGCTAT GTGACCTTAA ATATCTGTAA AATGGGAA1TT GATAATCAGA ATTAAAGAGC

GTAAAGATCC

TAGAGGCAAC

GAAAAACCTA

AGGTCCTGGA

CTGGAGAGGA

AAAGATTCAA

TACTrCCCAG

GCCACCTCCT

TTGCTTCACA

CATTCTCTGA

'TTTAATAGAA

ACAGGCATAC

CCACTGCCAT

ACCATAGTCT

GGCTGGTTTG

TACTAT-rTTT

ACAAGAGGAC

ATCTGAGACT

TGGGTGGCTT

ATAAATGATT

AAAATTGGAG

CTTGTTGTCA

TTTGCTCATC

ATCTTCAGGC

GAAGTCTTGA

ATAT1TTGAC G1TF17CAGTT

TATTTCT-TT

ACTCACTGAA

AAGCTTGAGC

CTITGATCCAT

CTCCTTCAGA

TCTGAGCAGT

TCCAAGCTCT

AT117TTGGAA

GGTCTGTCAC

ACCATTCTCC

TTGTATrTTA

ACCCGCCTCG

AAGTCGCCAG

TTCTCTTCTC

AAATCTGTCG

GTCTACATCA

TAAACTAACC

GAAGAATGTT

AACACTAAAA

TTCC'I1TTCCT

GCCAATCTCA

GTGTGACCCT

ACTCTCTTAT

GCCATTGTAG

AGAGGGAGGG

rTGAGGGCAC

CCATAACAGA

CAAAGTGAGC

CAATCTGTAA

TGTTAGAAAT GCTAATTTTA TGAGAATTTG CCTGTCCTTC TCCATCTGGA TGGGTGGGAA CTGAGTGAAG GAAAAGAAAC TGAATTGAAT TCTAGAAGAT AGACCTTCGG GAATCTCCAA AGATGCCCAG TGAAAAAAGA TGAAGACTCT AATGCACATT

CAGTTAACCA

AGAATATGAA

ATTJTCTAGGC

AGTAAAACCC

GAAGTAGGGA

TTGTATAAAT

ATGCCACAGT

AGCATGTTAA

TCTGCTAAGC CGGCAGTfrC CCAATATACT TATGCTTCCA ATGACATGAA AATATTGAGA ATAATCTAAA CTITGGAGATA CTATGGGTTT AAAACCAGCC ACATGAA1TI' ATTATATATA CAATAGCATr

ATITTCTACC

TGTGATAGCA

TAGATTTTAG

TCAGCAAGTC

TGGCAATTTC

TTTTCT

TCAATCCTTT

TT-rCAACAAT

TATAAGAAGC

TCTACTTCTA

ACCCCTTAAA

CTGCTCCCAT

GGCTTTGCCC

TTJTGTGGGGG

GACTCAAACT

CACTGTGTCT

GGGCTACAGA

GCTCCTGGGT

AGATCTCCAC

GITI=CCAC

CAGACCACTA

CTTTTCC'IM

CTTATCTCAG

ATAATCTYTTT

TrAAAGTAAG

CTGTAGCCTG

CAAACTCTGG

GTTCACACCA

AGCTCCTCAT

ATTCTAGTTC

GTCACTCATG

GATTCATGG

GGATCCATCA

CATAGCGTCT

CCTGGGCTCA

AGCCCAAAAT

ATGGACGCTG

GAGCAGGCCC

AGTGGACTTA

TGATAGGGCA

ATAAATATAT

TATAAATGCA

GGT'TCCCACA

TTTGG1TTCC

ATATCTAAAA

AAACTCfl

CCTTCAAGAA

TTTAAGGTGT

GCTGGTGGAA

ACAACAATCA

CAATGCTCTT

TGCTGTTTTA

TCTTCCCCAG

CCACTAAAGT

TCTTGCTGTT

AGGGTTGGAA

TAYJTCTTAAT

GACGAATCCC

CACCCTGTCA

AGTGATTCTT

GTATATCATA

GGTTACCAGA

ATTGTCAAAT

AAATAGTCAG

ATAGACTAAG GGTCTCTACT GTAGTCATGC AAATCTGCAA GCAAGGTATT AACTCTCTCT ATTCATAT CATAATGCTG CTGGGATATA TAGTTAATAT YFTGGAGATG ATCCGCCAAA TAAATAACTG TCAATGATGT TAGTATTGAG AAGCCCATTT ATGGTAAAGC AGCAAGGCTC AGACGCTTITA CCTTCTTGTG GGCACCATAG CTGTATGTTC CAAATAAGTT TGGAAACACT ACAGTCTTGA GAAGTCCTGC TGATTATGGA TAGT1TUTTC ATGCATGAGG 'FrCTTCATTA CAGCATTTAC CTrTCTGCA ATATCTCCAA AACCACATTC CAATGTATAT CAAAGTTACA AACAACGTAA ACACC11TAAT CATATCAGCA ATAAGGCTGT TTTCCTTT CTATTCACAA TI'ACATTGTT AGCTAAAAAT GGTCTTGCCT CAGTGTrGAT AGTTTGACAT ATCAATTGAC TGATAGCATT TTACCCACAG TCAACTAAGT TTATGGAGTA GAGTATATTC TACCTCAAGA TTTATCCTGA GATTGCAACA TCTATCTCAT 'FUGTGC'FrAC TCAACTTCYIT ACAAACTCCT GGCATCTAGA ATGGTGAACG TATCTATGGA AGCTATAGAT CCCAACCTGG AATGCAGTGG CCACCTfGGC CTCCCAAAAC ACTAATGAGG CTTGAAAGTC CATGAAAACA ATACTCATCT GAGCAGTAGT ATCTTGAAAG TAAACTATGC TGTAAACAGA AAAGCAGAGT AGATTTGGCA TAAT[CTCTA TGGCAAATTG AGCATTrGGCT TCAACTTTTfT YTTTTTT- TTTTTGAG

CCAGGCTGGA

TGCCTCTGCC

GTACAGACGG

GCCTCCCAAA

CTGTGTTAGC

TAGCTATGAA

TTTIGGTGTAG

TTACTTCTGC

TCCACTAGCC

GGGCCTTGGA

CTTrCTTCAT

TCAAGAATTT

GiTrTACACCA

TCCTTTCATT

TAGGGGCTAA

GGTTAATTAA

AGATGGGGAA

AGGTCATGAT

TATAATGATA

ACATGTCA'Fr

AAAATTCAAT

GTGCAGTGGT

TCCTGAGTAG

GGTT-rCGCCA

GTGCTGGGAT

CTCTAATAAG

AATCTTAGAT

CCACCTTCAT

TTCACCT-rGC TCACATTC1T

TTACAC-IMG

ATCAGCAATA

TTCCTTTCTA

TGCCTTT1TC TGAACACIrA

CACAGCTGGC

TJ7TGCCTAAT GCAATCTCGG CCCACTGCAA GCTCTGCCTC CTGGGACTAC AGGCACCCGC CACCATGCCC TGTTAGCCAG GATGGTCTCG ATCTCCTGAC TACAGGCGTG AGCCACAGCG CCCAGCCTGT AGAGTCTGCC TGTCCTTTCA AGCTTTGAAG AGCATC3TCT CCCAATAGGA AGCCA1TTTT CATTGATCTT ACCTAGATCC GCTGGATAAC ACTiTrTATGT TATGGGGATG GCTCCTFTCC C'TrACAGC TTCCTCGCCT CTCTCAGAGT GTTrFAAGGGA ATGCTGTGGC TGGTGATT AGACTGTJTTC ACTrCTTAC TATITGT TrCACAATTT GACCGYTrTGA TATGAGAGGC ACTAAGCUTC ATCAT1TAG CTrMAT CATGATGATG CCTGGCTTCA AAGCTTGAAA GACT1TAAG 'ITGAAGCCAA TGCTCAATTT TTTAATATTA TGGTGTCTCA GGGAATAAGG ACAGCCAGTC ATCAGAGCAC ACACAACATT TATCAATTAA ACTTCAAAAC AATTACAATA ATGAAAAATT TGAAGTATTG GGAAAAGTGG TGCTGATAGA TATCTACATA GTACCATAAA ATAGCTCACT CCCTAGCTCG TTCAAATCCC TGTCTCAGCA TGTTAAGTCT TGTAAGCCCA ATAAAATAAA AAATCATTGA TGAGAATTAC CAAAACGTGA CTTACTTCAT GCAGGGTTGC AACAAGGTAT ACCTGTTTAT GAGACATTCT AACCAACATA AAAUTGCAAA GTATCAAATG GAGACCACTG TATATACAAG CCAACAGAAC CCTAGAGAAA TCTMTGCT GTGTACAGAA CTAATACTCA AAACTGCAAA AGCATTAGT-r CTTCTCCAAA GAAAATAGTC CAC1TGGTAG AAACAAACAA AAAGAAAAAA AAAGAAAGAA AAAACATITr TTACAAGAAG ATTCAGTCTC TTACCTACAT AAGCAAAAAT ATGAGATGTT CTCUTATCAT 'TITCCATCT ATCTATAAT CTGGTGCT GACTTAGACA CTCATTTTCC TT1TGTACG

TGACCATGTA

AAGAAATTTG

AGAACAGTTG

AATGAAAGAA

AAATGTTGTA

AACAGCCCCA

TGAAAGAAGA

AAAGTTCAAG

GCTTTGCTTI1

TGATGTGTTT

TATGAAGGAA

ATTACAAAAA

AAGAAAGTCC

ATAAAGACTA

TCAAGAAAAA CTTGTTTrTGA CAT'rrGTT GCTGAGTGAT GGGTCCCTAA

TGAAAAGTTC

AGGTOTTTTrA

AGCCTTCTTG

TTCCAAGGCA

TGACAAGGCA

TATAAGGACA

AGCATGATAT TGTGTGAATT TTTCATGGCT AATGATTTTT AGAATATGAA GCATTCAGTG GTTTAAGTTG GTTGTTATAA TCTTAGAACA CACTGATTCA CAAATAAGCA GCTTCTCTCA AATATAATAA ACTCCTTGTC GGTGCTATGT CTAGAAAC1T AAAAATATAT ATATATATAC AAATTGTGGA AGCAGGGTGT AACTGTTTAA AAGGGAGGGT ATCCUTGAAA GCTTGACACT CTCAGTTTCA TAGATTGCTG GTACGGATGT AAAATAGTGA TAGCAAAAGT GCTTATGCAT TTATTCTTTG ACCTAGTAAT CCTCAACAAT AAAAATATAT ATACATTAGG TTATTAGTTA TGACTCTTTT GACGAGGCTG AGGGAAAACA

CATCCCTATA

CCCGCT-rCTA TGGTTTAAT7

TATGGTATAT

GAGTATTTGT

GAAAATAAGT

AATGAAAGTG

TTACATAGTC

TAATACAAAC

TAATCCAACA

AAAATTGCAA

GAGAGGAATT TGGCAATATC GGATTAGTGG TGAAGATACA TTTAATAGCA AAATA1TTAA AACAACCTAC ATGAACAAAT AGGAGACTTFA CTGAATAAAC CTGTACAATA AAGTGCAATT CACTTATGTT GTTAATTTGT TCCAAAAATC CAGAGCCAAA TATGCTCTCT TTAGTATAAG AAAGGGGAAA TAAGATATGT GTGCATCTGT TTATTTGT ACAGAAAGGA TAAGTAAGAA ACTAGTAAAA CTAGTTATCT CCTAGTGUTA GTAGAAATAG AATTAGGCUT CTTTGAGTAT ATGTTTATAT ATAGTTTrGA CTTTITGAA'F[ ATGT[ATGT AAAAATATAA ATTAATCAAC AGAAATAACA AAAAAAGAAG AAATCACAAG CTTTAAAATT AGAAATAATT GAATCTAACA GTATATCAAA GTGATAACGT AAACTCAGAA GAAAAAAACA

TACCAGTGGA

AAATATCTTG

TGAAATTAAT GTTCGTGTAT UTATCAYFCT GGGAGTAGAG CCATATAAAC TCATTATTT TYFATCTrGAT AGACAGGAGO AACAAGGTCT TCTTGGAGAA

ACACAATATT

AACT~rAGCT

TATAGAATTG

AAATATAAAT

AAAAATTATA

GCACCCCTTT

AAGACTGATT

CTAACTGTAT ACATTCAGTG TGTAGGATTT TTATrGGTAG AGTAAATGAA TAAATATGTT ATGGACTTGG CAAATGAAAC AGTGTCCTAG CTCTGTTACT CTCAGAACAT GGTTTCCAAA CTAGGTCTGG ATTAGGTAAA

GTTATAGTCT

CAATACTAAT

GATOTTATTG

AAAGACCTGC

GAAAAGGCCT

TGCCATTCTC

GTACAACGTT

ACAAACACAC

AAGGACAAGA

GTACTAATTC

GGAACTAAAA

AGAGAGATAA

AGAYJTCAATC

CATTAAAAGG

AGTCTGGAAT

GTGAGGCAAC fT-rTGCTGA TYrGAATCCTC

TCTAACACTT

ATGAATATCA

TAATAATCAA

TATI'CATACA

AAGAAATCTA

TCATGTGTCT

CAGACCACCC

TTAAGATTT

T-rAGCTTGGA TrGAAAATGT

GTAGTATCAT

CTAAGGAAAT

ACACTGGAAA

AGATTATGAG

CCAATTGTAA

GATTGGTAGA

T-TTAATTTYrA TI7ATTCTGTT

TATCTATAAG

ATTATGGACT

GGCAGCACCA

CAAGAGCAGA

GTACTCTGCT

TGTJ7GTTTAA

TJTCTGTCAGT

GAATGGGAAG

TGAGTTGCTA

CACTAGCATG

T-ITTTCTCAT

ATCAGAAGTA AGAAAGTGCT CAAAAACATG ACTGGCCATA TTJ7AGGACAA TCGAGCATCA AAAACAAAAA ATAATCCATA GCCCACAGAA AATAGCAAAG ACAGAAGAAA TGACAGAATT TTCAGGCAAG TATTATTAAT GGATGTATTA GTCTGAAGGT GTCACCCTAA ACATAACTTA GCAGAAACCA TCTAATCTA GTGATCAAAC CCTAATATGA TOCACCAGGA AGGATGCAAC AGGGTAAAGG CAGCTTrTCTC ACTTACTAAT CTTACTTTCT TGTCAGCTCA GAAATTTATT GAACCATTCA GAGTTTCTAA CTCATTGTAT CTAACTTTAA AGTTACTJ7GT GTGTGTCACT GTGGCAAGGC TATAAAAATG TTTACAATCT

GGAACATGTC

AATJTGAATAG

CAACCTAAAT

AACATAGAAG

TAACAAAACA

GTCCATTACA

ACAGTTATGA

CTATTAACAC

GGAATCATTT

GAGTAAATTT

CTJ7ATAAAAA ATACGTGCAT ATAAGGATAA AYI7ATGGCTC CTrrGCTGT CT[AATTT-FT AAATTCAAAA GAATTTGCCA CTCATCTT7G CTTAGTATAG TTJTTGGCAAT TTCCTCACGT ACAATATAAA ATTAAAGAAT CTAGCCCAGT TTTITTCTCA CACCCAAGTA GGGAGGAATC ATCCCTAGGG GAGAAGATCT TGGTGATGAT AAAGTAAGAA AGAAACAACT TCTrGCTAAC TACCC~rTCA TGGATGGAGG CAGAGGAAAG TCTGCCT-rCC ATCTTTCTTA TCAGTTCAAA AAAAAAAAAA AAATGTTGAG AATAATGGAT GGGGAAGAGA GGGGGAGCTC TrAT17TACAG AGAGAAACAT CAT'TrTGCAA AACACCACTG CTATTGCGTA AAACCAGT7G GGGAACAGGA TTACAAGTGG AAAATGGTGC CTTTACAATG TTAGTATCAC CAATAATGGA TCATACTGAG GTCATGAACG TJTGTATTCTT TTGTA'ITCAA CAGAATTGTT GGTTY[rAATT CATmTGGAT TAAGATGATT TTTATCT1TT AT~fCAATACT TGCCAAAAAT AGAAAACAGC ATGGY7TCr CAGATTCACA TAGCTTT1T-T GCCTAGTAAT TTTATTTAAT ATGACTCTTG AGAGTTUATT AAAGCATAGC AATTTGATTT GGGCAACCAA ATGAAGCAAA CACTAAAATA TTTATrGTGA GAAAACCTGA ACACAAAACT TACATATACT AACAGTACAA ACAAAAAAAT AGTrGCGTTA TCCTTTACA YJ7TTGATACA TTATTrTAAT CCACTrCAAG GAAAAAAGAA ATGTGTTCGA GTAAAAAGAG AATACTATTA ATAATITCAG AACTGGTACA TGGAACGTAA TTAATAAATC AGTGGTCCCC TAGAGGCCCA GTGTAGAGGT AATrfCCTGAG CAGACAGTTA GCTGAGAATT ACCTTJ7CCAC CCACGTTTCC CTGTTCTGTT AGAACCAAGT TTGCTCTTAG TCATTCACTA TTAGAATGTA GACCTGAATT TAAATCCCCG CTGAACCTCA GAGAACATTC TTrCATT-rGTA CT1TTATAAA C1TTATAACC TAAACATGTG ATATGATAAC AGAACTG'FIT TGTCTAACTC GC1TATCCT CAAATATGAC 'rrAAATCCGA AATGACAAAC 'ITACATGGT TAAACATCAG 'FrTGAAAACT GCTrATATTT GTGTTGTCTA ACATTTFCA GCAAACACTG CACGTI=GC ACTAACAATA CTAAGATATG GATGAATGAG TGAATGGTCC AAATGAAGAG ATAAGTTGTG TTTGTCAAT AGCTATGAGA ATTTTACCAT TAGGTATACA TATAAAAAGT TATTCATTAC CTATCTAAAC TATGGTATAT CTAGGTCATA TTAAATrAAC TTGGCTTGGG TCTTCAGCAA CACTCAGTCA CYJTATCATGC AGGAGCAGAC TATAATGTGA CCCTAGACAA ATlAATCTAT ATTrCCACTTG GTATCATTAT GT-rGGTAAAG GTTCAGGT-rT AGAGAGTGTG CCACTTTCCT CCACAAACAA

AACACATTCT

GATGGCAAGT

TTATTCTGAG

GAATTAAAAG

ATCCTCAGGA

AAATCATACA

AGAAGACTAC

TTTATUGGCT.

TTTTGTTTAG TCTITTGACAT TGTCTAAAUT GAAAAGACTT AGAATTTCCC CAGGCACCAG GAAATCAAAA TGGAGATCTr AAATATTAGT ACAAGTAAAA TGACCCAGAA A1TCCATTTC AGTATCGTT-7 YI7CATAGGAA

CCACATGGTT

ATTGAGGAAT

TCTCCAGGAA

GCAAGTTTT7G TGAGAATGGG ATTATTTACA ATGAAAGACA TTTCTTrCAGA AATACCCACG AAAGTTTTAA AAATCAGAAG GAAATCAAAT GACTAAAAAT GTTAATATAA GCATATG1T AATTGGC'TrC TTAACATTGC ACTCCAGAGT TAGACTTACC TCCTAATACC ACATATCATA GAGCAGAGTA GGACACAGGT TCTCTGCAGG CAGGCAAATC CCAAAGAGAA GGGAGGAAAG GGCTGAGACA CTGCATGGTC AATT-rCTTCT GAACTCTGCA ATGTACGGAG GTGGACAGTG TCCACAAAGA TFGCTCCCCT GGACCCACCA TCATAATAAC ACAACGGCTT TGMTTGTTT TTIGT=ITGT 94

TTTTTGACAC

CTCCACT-rCC

ACCATGCCCA

CTCTTAACCT

CCCAGCCCAC

CATATTTCAT

CTGGGTGAAA

CAGATAYJTGA

AATCTGGATT

1TCTGAGGCT

CCTATTGAGC

TJTTTTAACTT

TGCTGAGATC

AGCTCT-rCTA CCTTATrACA

CTAGACATTT

GGAGTTTTGC TCTTGTTGTC CAGGCTGGAG TGCAATGGTG TGGGT-rCAAG TGATTCTCCT GCCTCAGCCT CCTGAGTGGA GCTAATTTTG TATTT-TAGT AGAGACGAGG TTTrCTCCACG CAGGTGATCC ACCCGTCTTFG GCCTCCCAAA GTGCTGCGAT AATGGCCTTT TGTTTACATC TCTAGTGCAG CACTCATT-rC C1TTTTATTFT TATACAGCAA TTAGCACAGT GCCTGGCATA

TGATCTCGAC

TGGGATTACA

TITGGCCAGGC

TACAGGTGTG

ATGTTCTTTC

AGGAAAATGA

TCACCACAAC

GGCATGCACC

TGGTCTCAAA

AGCCACCGCG

AAGAAGAATA

TCATTAAAAG

AACCTAATAA AGCTACTGAG GATAGGAACT GCAGACCAGC ATGGAAAGAA AACTATGAGC AGGCAAGAAG TATGCT-FTTG GAATATAGAA CATCATCCTG

ATGATAAGAA

G1TTTGTCCTT

TGACATCAAG

TATATAGTAT

TCCTATTTGT

AAAflCTTGT

AAAACAGTAT

TGAATTAAAC

AAAGGCAGAA GATTTAGTAT AAGAATCATA T'17GTCTTAT ACTrTCTTTT

TTAACTGACC

ATCTTTTAGT

TCATTCATTA

CTGCACATTC

AAGTCACATT

ATTATAGAGA

CTGTTTTATC

TITTATTTTG

CCTAGAATTT

TGACCATATT

TAACACCTGA

GCCTTGTTTC

TTCTGGATTC

CTTACCTACT

CACTGTTTCT

TCCAAACTGC

CCACATGAGT

TTTCTCTACA

ATTATTCTGG

TTAATATGCA

TCGAGAGAGT

CACTTCTCAG

GTTCTTTAGA

TGTTAAATGC

TTTTTAAGTT

TTATTGAGCA

GGTCAGTCTC

AAATGATTTT

TTCCACATGT

TTGGATCATT

ATCCAGTGAA

TCCAT17CTC

TAATTATAAC

TGTTACATTG

TGATTGCAGA

AGGCAGGTAA CTTGACTGGA CTCAAACTCC AAACTCTAGG TGTTTAGTTC TrTAAGACTT ATTGGCCAGG CACGGGGGCT CAAGGTGGGA GGATCACCTG AGGTCAGGAG TTCGAGACCA

TCCTCTGTAA

CATGCCTGCA

ATTGACTTGT TTTTTCCATC TGGGCAACTG CAGTAATCTT ATCCCAGCAC TGTGGGAGGC

ACTAAAAATA

CAGAAGAATC

GGGTGACAAA

TGAAGTTCAT

TCTCCT-rTTC TrACGGCAGT C1TGATGCTA

AGTCTAAAGA

CTGGAAc3CTT

ATGTACTTCT

UTTCCTACTTr

CATTTATAAA

TGGAGCCAGA

CTGCTAATAA

CAGTTCAGCA

AAGAGGGAAA

AGGGTAACTG

TATAATTCAA

TCTCATGTCC

GCATTAAGTC

TAAAATCAAA

CCAAATGGGA

CATTAACATT

AGGTGGGC'11

GCTTTTCAC

ACCATTCTGG

CAAAAATTAG

ACTJTGAACCT

AGCGAGACTC

GGGTCAGCTA

CCGGGTGTGG TGGTGGGCGC GGAAGGCAGA GGTTGCAGTG CCTCTCAAAA AAAAATTTAT TAGATCTGGG CACGTTATAC GCCTGGCCCA CATGGTGAAA CCCTGCCTCT CTGTAGTCCC AGCTACTCAG AAGGCTAAGG AGCCGAGATT GTGCCACTAT ACTCCAGCCT TGGCACTGCT TGGCATCTGC TATGAATACA ACAGAATTTG GGTCTCCCTT TCTCTGGATT TGGATTTCTT TTCTCATIT CCAGCAGCTG TGGT-rGCCCT AAACTCGGTC CTCTGYTCT AAGATTJTGGG AACTTTTAGG TTTTACCTGC CTCTCAGACA AAATAAAAAA TAAT'17TCAT CTCCTT-fCTT CCAGATGTAG ACACCTCTCT AATT-rCCAGT TGCTTTTTAT TGCTCTCCAG TTATCATTGT TTTCTGTGGG AGAGTTGGTC TGATAAAAAC TACTCCCCCA AAACTGGAAG GTAATTATGA ATAGACTTTG AGTAGTAT[C TTCMTGGAA AAGGATTTTA ACTACTCCCT TTATTTCCTG TTTrTCTCAT CCGTAATCTT TTTA17TTCA TACTTCCTAA GTCAGACAAT GAAGATTCAG TGACTGCTAT CAAATGACCC CCATATTACT AAATACAATA TCCCCAACTG AAGAAAATTT ACTGTTIATT AGTAAACAAT GTTGTAGAAT AGTAAAATAT TGCTGGGC117 TAATCAAGGT TAGAATCCCA GAYFCTAACT TACTAGCTGG TGTATTAGTC CTTTCTCATG AGACATACCC CAGACTGGGA GACTGGGTAA TTTATGAAGA AAAGAGGTTT AATrGACTCA TGGCTGGGGA GGCC'rrAGGA AACTTACAGT CATGGTGGCA GCAAGGAGAA GTTCCAAGCA AGCCCCTFAT AAAACCATCT GATCTrATGA GAACTCACTC ACTATCACGA GAACAGCATG CCCTCACGTfr TAATTACCTT CCACCAGTTC CCCCCCATGA CACATGGGGA TTATGAAAGC GATGAGATTT GGGTGGAGAA ATAGCCAAAC CATATAATTC CACCCCTGGC CCCTCTCAAA TCACATTTCA AAACTCAATC ATGCCCTCCC AACTGTCCCC CAAGGTCTTA ACTCATJTCCA AAAAATCCAA GTTCAAAGTC TCATCTGAGA CAAGGCAAGT CCC1TCTGCC TATGAGCCTA AGCATGTTAG TTACYJ7CCTA GATACAGTGG GGGTACAGGC GTTGGGTAAA TACACTGATT GAAATTGCCA AAACAAAAGA GTTACAGACC CCATGCAAGT CCAAAACCCA ATAGGGCAGT AAAGTTCCAA AATGATCTCC TTTGACTrFCA TGTCTCACAT CCAGGTCACA CTGATGCAAG CCAATGGCCT TGGGCAGCTC TGCCCCTGTG GC1TrTGCAGG GTATAGCCTG CTTCCTGTTT AGGCTGACAT TGAGTGTCTG TGGCTTTTCC ATGAGTATGG TGCAAGCTGT TGGTGGATTT GGTCTGGGCC AGGTGCAGTG GCTCATGCCT GTAATCCCAG CACTTrGGGA GGCTGAGGTG GGGGATCACA AGGTCAGGAG ATCGAGACCA TCCTGGCTAA CACGGTAAAA CCCAGTCTCT GCTTAAAAAA TACAAAAAAT TAGCCAGGCG TGGTGGTGGG TGCCTGTAGT CCCAGATACT TGGGAGGCTG ATGGCGTGAA CCCAGGAGGT GGAGCTTGCA GCGAGCTGAG ATTGTGCCAC TGCACTCCAG AGAGCAAGAC TCCATCAAAA AAAAAAACAA AAAAACCATT CTGGGGTCTG GAGAATGGTA CACCACCAGG CAGTGCCCCA GTGGGGACTC TGTGTGGGGG CTCTGACCCC ACATTTCCCT CCTAGTAGAG GTTCTCCATG AGGGTTCTAC CCCTGCAGCA AACTTCTGCC TGGACATCCA TACATCCTCG GAAATCTAAG CCGCGGAGGT TCCCAAACTr CAATTCTTGA CTCCTGTGCA CAATACCACA TGTAAGCCAC CAATGCTTGG TCAGGGCTTG AACCCTCTGA AGCAATGGCC GTTGACACCT MrAGCCTAG ACATCTAGGA CACAGGGCAC CATGACCCGA AGCT-fCATAA CC'TGGGACT AGCTGAGGAA ACCATTTC CATCCTAGGC CTCCAGGCCT GTGATGGGAA GAAGGTGCCT GACATGCCCT GGAGACGTTT TCCCCATTGT CT-rGGTAACT AACATTCAGC GCACCAACTr ACTTATGCAA ATTTCTGTCA CTGGTTrGAA TTTCTCCCCA GAAAACAGGA CTAYI'GCATC ATCATGCTGC AAAT1TCAA ACTTTATGC TATGCTFrCCT G1TGAAGACT GAAAYI17CT-r CCCCCAGATA CCCAAAATTA TCTCTCTCAA GTTCAAAGTT CCACAGATAT AAATGTITGCC AGTCTCT17TG CATAGCAAGA GTGACCTTTA CTCCAGITrCC CAACAAGTIrT TATGAGACCA TCTCAGCTTG GACTTAG'I17G TCCATGTTAC TATCAACATT TTGGTCAAAG AGTCTCTATG AAGTTTCAAA CT-rCCCCATG T1TTTCCTGTC TTCTAATAGC CCTCCAAAT[ CTGTCTGTTA CCCAGTTCTA AAGTCACTTC TACATTTG GGTATCTTTA CAGCAGTGGC GTACTAATTr ACTGTATTAG TCTGTTCTCA TGCTGCTAAT AAAGACYUAC TCGAGACTGG AAGAACAGAG GTI7CAACTGG CTCACAGT7C AGCATGGCTG GGAGGCCTCA GGAAACTTAC GCAGCAAAGA GAAGTFCCAA GCAAAGAGGG AAAAGCCCCT TATAAAACCA TCAGATCTTG CTATCATGAA AATAGCATGA GGGTAACTGC CCCCATGATT AATTTACCTC CCACAGGGTC

AGGCAGGAGA

CCTGGGCGAC

GCCCTTACAG

TCTGCACGGC

GGCA1TCCA

CCCACAGGCT

TGAGCTGTAC

AGTGGGAGGG

GGGCAGCCAT

TCCGTGTGCA

TI7TTTCTTT TrGCGGCTTA

CTAGGGGACA

CTCATCTCCA

CCATTCAACA

TTTCCAACCT

ACTCCCCATG

GTAAT-rATA

AAACATGGTG

TGAGAATTCA

CCTCCCATGA

CAGGTGGGGA TTATGGGAAC TACAATTCAA GATGAGA17T GGGTGGGGAC ACAGCCATAC CATGCCAGCT AGAGAGCCY[ AAGAAAGTCA CCTAATCTCC CACCCCrTrT ATGGGATTTC TOTGAGGACA ATAGCTACTC AAAAAATAAT AGAAACAAC/ AAAGCAAAAT TGAGCAGAAT GTACAGAGAC CCCCCAGTAT CAGCATCCCG CACCAGAGTG YITTCATCCA AAATCCATAG TITATATTAG ATGTATAATG ACATGTAT7C ACCATTACAG CTTCTTCCTA TTCATCACTC CCTCCCCATT TTTGTCTTYJT CCTGAATGTC ATATAGTTTA TTAGTAATAT GCAYITGATG TTCTTCCATA TAATATTCCA TTGTCTGGAT GTACTACAGT TCCAAGTTTC AACAATCATG AGTAAAGCTG TTTTCAGCTT TTTTAGCTCC ATTCCTAGGA TGTAAGAAAC TGCCACGCTC TTCCTAACTG CTG11TGCTCC ACATACTCAC CAGCATTTGG TJTCCTAGGTA TTCTT-TTfGA AGGAAATAAT TCCTTTAT ATAGTCCATC A1TTAATGAA TCTCCCATGA ACTCTGACAA TCTCCTAAAT TGGTCTGTCT GAAGCATGGC TTTTTTT CCAGGCTGGA GTGCAGTGGC GCGATCTCGG TGCCTCAGCC TCCCGAGTAG CTGGGACTAC AGTAGAGGCG GGGTTTCACT GTGTTAGCCA TGCCTCCCAA AGTGCTGGGA 'rrACAGGCGT TfTGAGATGG AGTCTGTCAC TCTGTCACCC CATCTTTCAG GTTCAAGTGA TI'CTGCCACC ACACCCAGCT ATTYJTTTTGT AFTTTAGTA CTGACCTTGA GTGATCCACC TGCCTTGGCC GGCCTGAAGC ATGACTGTTG CTTTAATCAT CACCTCCTGA GCTAAATTGC AAGCTrrTAT GACACATATC AAAAGCTGTT ATATAYJTGTT TAGCACTFFC ATACCGTTAA T-rTTCATT-r GTTATCATTT CCCTCCCAGG CCTIrTTCTCC AATTUGTTCA GTGCACAAAC TCTT-rATCAC CAGTGTCTTA CAAATITGTCT GGTATATAGT ATCCTATTCC TATATATAGT ATGGTAGACA AACTTGTGAA TATGTI'ACAT TTCATGTCAA ATTGTAAGAT TATCCCGGAT TAACCAGGGC TCCCAGCTGG OTTAGAGAGA GATGAGACAG CCCACTGTTG CTGGCTTTGA AGATAGAGGA TAGGAAAAAG CCCTCATCTG ACAGCCAGCT ACCACTCAAA TGAGCAAGGA AATGGATTCT TTGAT1TAG CCAGGTGAGA CCTGTTTCAG GTATGCTGCT AAATTTGCGG TAGTTTATTA AGAAAGAGAA TGAGTTCTTrT CCTGATAATr AY[CACTGGT TCCCTAGCAA ACCAGCATGT AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA GCAC1TCAAG TGAGGAAACA AGAGOTAGGA TGAGTTGTTT TCCCTTGGAG GCTATCGATG GAAGTAAGTG TCAATGGCTC CGACTTCCAA TGGAAATGAG CTTAAATGGG GAATTTCCTG GCCTACAATT ATGCCAAGCA GTCACACTAT CAAACAACTr AATAATCATrF TATACTAATA TGGCTATCCA ACTGGAAGAG AAGACAGGAA CCTCTGGATT CCCCTMCC TATATTACC CAAGTATTAT GTCACGTCTC TGAGAATTAT TGGAGTCTGG AGTCATGAAG GTGACATACA TAATGGCCCT GAAAYJ7CTAT TGAATGCCCA ACAAATAAAA GGTTTCCTAT TTGTTCAACA AAAATAATGA AATGATAACT AACATAGCCT TGCATAGTGT CTGGCACAAA TTTAAAAAAT GTAGACT7TA TfTTTTrAGAG iTUTATGTAC TTTCCGTATA GCACTCCCTA CCCCCAAGCA CAGATAGCCT GTACATTTAT TATAACTGAT GAATCTATAT TGACGTGTCA GGATGCCTCT TGGTGTTGTA CCTTCTATGG GTJTTTGACAA TATCATAAAG AATAGTTTCA CTGTCCTAAA AATCTTTGAT AATCCCTGAC AACTACTGCT AATTTTCCTG TCTCCATTGT AATATACAGT ATGTAGGATT TTCAAACTGG 1TATTTCAC TCTTTTCAAA GCTTCATAGT TCAATATTTA TAGAATTGAA TFATGTATTC ATTCACCTAT CAAAGAACAC CTTGGTrGCT CTATAAACAT CTATGTACAT GYTJrTGT GAATTGAACA GTGCAATTGC TGGATTGTAT GATAAGGGTA TGTTTAGTGT GATGTACTGT TTTGCATTCT CACCAGCAAT GAAAGAGTTC TGTCGTCAAT GTTMGAGCA ATAGCATT17 GATCTAACTr ATGACAGATA ATAGAGAAAG GATATACGAG GACAGTTCTG GGACTCTGTC CACACTTGGT A~TrAACT CTGATCCTCC CCCTGTTGCT GGCACACATG GTTGTGTATC AGGCCCCCTG TTTTT7TTTTr T-FTT1rGAG ACGGAGTCTC GCTCTGTCGC CTCACTGCAA GGTCCGCCTC CCGGGTITCAC GCCATrCTCC AGGCGCCCGC CACCACGCCT GGCTAATTTT TTGTATTT-T GGATGGTCTC GATCTCCTGA CCTTGTGATC CGCCCGCCTC GAGCCACCGC GCCCGGCCTT TTTTTTTT TITTTTTT-FTT AGGCTGGTGC AGTGATGCAA TCTTGGCTCA CTACAACCTC TCAGCCTCCC AAGTACCTGG GAGACGTAGT TTCACCATGT TCCCAAAGTG CTGGGATTAC ATGAAATACT GCTCTGTATr GGAGCACAAA CCATATTTAT

ACGTGAATTG

TGTGCCCAGC

TFGTGGACAA

CTCTCACTGT

AGGCACTCAA

GATCAUrGAT

AAGGGACTTT

CAATCTAATC

AT'TCTITCTC

CCCTACTCTG

TGTGTGGCTC

TCTCAAGTGA

TAAATGTYT

ACCCAAAGAT

GCTAATGTGA

ACATGAGACC

AGTAAAAAGG AAAGAGATTC ACTAGOCCAC AAAACAAGGA AGAAAGCAGT CCTCTGACCA CCCCTAGAAC CTCCAGAAAG ACT1TTTGACC TATGGAAATA CTGAAGCAAT GGAAAGCCAA TGTAAATATT TGGGTCTTCA CCAGTCCTGC AGCCTCCCTT CCCTGAGTAG TTGOAAAGAA GACCGGCATC TC'TJ7CTCAT GAYJTACAGGT GCCCGCCACC TGGCCAGGCT GGTCTCATTC AGGCATGGGT CATCACATGT GTTATCTATT TGAAATGCCA ATATATTAGC ATGATACCAT AGTTAAGAGG ACCTCTGTAG TGAAAAATGA AATGAATCCT AAGAGAAAAT TCAGTCAGTA GATAGAACAG AACATCCATC Yf7GAATAAAT GCATACATGA GCCCAAATGC TGATCCCCAG TTAAGGATTC AGACCCTTGG TTAAAAAAGC AGAAAACATT AGGGCATGAA AATGACTCTA GTATGAGTGG CCYI7AAGAAA CAAGAAATTG GATTCTGCCA GAACACAGCT CTGTAATGCC TAAGATAATA AAGTTATT TACAGACAGA ATATACAGAG CTGGACAAGC TTFCACAGAGG TCTTAGGCCC AGCATATGTC AAGATGGTTG GAAATGGGTT ATGTCCCAGG CTGACTCTrG GAACCTGGAT CATGATGAAA ACTAGCTAAA CAAAGCCAGT GAAGCCAGGT TGGCT-UCCTT ATTAAGTGAT TCTTAACA TA'FrCCACTT GAAGTAGAAT ACTAAAAGGA TTGGCACCTG TATTTCAGGA TACAGTT-rCA CTGGCCAGAA AGACCTAGTT TAGCTAGTAA AAATAGTGAG

ACAGTCACAG

GGACTCTGAT

AATATATTCC

AGAGTCCCTA

GCAAAACGGC

GACGTGATCT

TCTCAGCACT

GTTGGTAGAT

TGTAGCTAGT

AAGTGCTGAC

TAACCTGATG

GTCCCACAGC

CTATTGTTAG

GGGACATGAT

CAACGGCTGA

CCAGGGAGCC

GGCAGGCCTr

ATTTGCTCCT

GACATAAGTG

AAGGAACTTG ACAATTTTCT AAT7ATGATT AACTrGACCC TCCAAGCCAG CACACTCTGC AAATACATTA GAATTCAT GYITGCAAT CTGCTACTCC AGTTAGTCTG TTTTACTTAT ACTTGACAAA AATACCCCAA TCAAAAATCC TAGTAGCTAA 'ITAGGTGACT TTTAAGGACT TATATAAGAT TAATTGACAG GCACTTfTCTA CACAGCCCCA ATACAGAGAT TTGAGTTCAC CTATGCCTTA AACATTACTA GT-fGGGAAAT CCTTATGTGA CAGGAACAAG CATGCTCTAG CTTATCTCAC GAT'TTCTTAG TAACAAAGCC ACTAAGGCAC ATTCTATAAA ATATITACAAC TAATAGTGGA TGTCCACACT GGTAAAATAA GTFGITTCAT

AGTCCAGAAC

TTGGCAA'Trr TAC1TACTAA

ATATGTAGAT

TTTCCCCAGA

AGTGCTGCTT

CTCCAAGATG

AGTCACAATr

ATAGGTCTAT

ATATGTGACC

CCTGGTCTCA

GCTGGTTGAT

GATGATCTGT CTTTTCCTGT ATfGAGAAA ATGGAGATAA AATGGACCAA TCCAAATAAT GGATTAAACA TGGGAATAGG TGAGAGAGAG AGAGGAATAC ATGGTGGCTC TCAGTGTCTG GCTrAGGCAG TAAACACTTT CGTTAATAAA GACGGAAAAT AAAAAAGGAA TAATTGGTGT CTAGGGGAAA ATAATGAGCT CAAGTTTTAA CACTCTGAGT TCCCGGATGT GAGACATCCA GGCGCATTTA TCCAAGAGGC AGTTGGAAGC AACGTrCCGG AcJCTTAGGAG AGAGGCATGA CCAAAAGCTG GTGGGACTGT GAAAAGGTAT GGCCATrCTG GAAAACTGTr TGGCAGYITC TTAGAAAATT AAACATGTAC TAACAACCCA GCAATTGTAC TCTTGAGCAT TTGTCCCAGA TAAATGAAAA AAAAAAAAAG CATTT1TT ACACAAAAAC ATATACATGA AAGTrFCATAG AAGTGTTATT CATAAAAAAC TGGAAAAAAC TGAGATGTCT TTATTGAGTG AATGCTTAGG CAAACGGTGG TCTATCCATA CAATGGAATT ATGCTTAGCA ATAAAGAGAA AAGAACTATT GATACATGCA ATAACACAGA TGAATCTCAA AGGAATTAAT GCTGAGTGGG AAAAAAAGCA CATCTCAAAA TGGTATATAC TGTACTATrT TATTTACTTA ACATTTTAAA AATAGCAAAA TCATAGAGAT GGAGAACAGA TTAATGGGTA CTGTGTTrTTG GGATGGGGAG TGAGAAAAGG GTAAGGTGTA AATATAAAGG GGTAGCACAA AAGAGCCTTG TGGTTGAAGG A1TCTATGTC TTGGTTGTAG TCGTGATTGC AGGAATCTAC ATGTGATAAA ATI'GTATGGG TCTACATACG CATACACACA AGAGCATATA AAACTGGTGA CATGTGAAGA AGCTCCGCAC ATTGTGCCAA CATCAGTATC CTAGTfTrCAA TATCAGACTA CAGTTATACA AAACATTGTC ATTGAGGGAA ACTGGGTAAA GGGAACACAG GACATT'TGGC ATATATTTTT GCAATTTCCT GTGAATCCGT AATTATTTAA AAATAACAGA TATACTACAT ATCAAAAATT TAATGTCATA AAGTTGATGA GTTTACCTAG TGGATAGCT[ TGTI7AATATC TGCTATAAGA CTACTGAAAA TGACAGTTAT GCAAGTATAA GCTCAGAGAA CYT-CCTCCC CCTrCGTAAA TGAAATGAGC AAAAGAAATG AAACAGGAAA GGCAAGCAGT ACTGAAAACA GGGAAGGGCT CTrCCCCATA TAACTATATC TGCGACTTCA ACAGCTATTC ATCCAGAAAC ACAGCCTCTT GCGCTAAGAG GAAACTTTGG ATAACAATAT GTTYJTCACTC TCCAAGAGAG AAAATGGATA GAT[AATI= TAAGAAAAAA AAAAAAACCT CACCAAT-FTC ATGCTGTGGC 1TGCACCTT AATCCCAGCT ACCTACAAGG CTGAGGTGAG AGGCTTACTT GAGCCCAGGA GTTCAAGGCT GCAATGAGCT ATGATTGATT GTGCTATCGC ACTCCAACCT GGAGTACTAA GCTAAGAGCT AAGAACACAG CTGAGAGCGG AGAAGAAACA AACAAATCTG ACCAATAACC CCCACTCCCC TCATTTTACT GGAGTGAGCT GAGACTGCTG GCAAACATGG CCTITGACCT AGCCTGAACT GTAGCAAAAG TCATCAGATA TTTTrCCACC AATCAACAGA CAGAAGTGOG GAGAAAACAA TCGTAGTTCA TAACTACAAC AAGCAGATAA ACGAAGGCCA TGGTGAGGGA TGGAAGACAT TGTGATATAT CAAAGGCAGG CTCATTTAAA ACTCAACCCA AATTCCAAAC AAAATATATA AT-FGAATATG TATTAATGCC AAAGGAGC'17 GAGTGAGCTr TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC ACTCTGTTICT CTCCCCATTC TTITGATAGGC ATACTIGCTG T1TrCTCACA GCCAAGGTAC AGAGGOGACT TAGAGGAACT AGAACTCTAA TACACTGCTA GCAGGAATGT AAAATGAAGC ATCTACTTCA GAAAACCATT TTATCAGTFI7 CTAGAAAGYI' AAACATAGAC CCACCATGCA GCCCAGCCAC TCTACTCCTA AGTAYIrTACA CAAGAGAAAT GAAAACGTGT CCCCACACAG TTGTATTTAA AGGTGATGGT TAGCCTJTGTG TGTCAACTTG GCTAGGCTAT AATACCCAGT TACTGAATCA AATAGTAATC TAGGTGCATC TGTGAAGGTA TITTTGTAGAT GTGGTTAACA GCTACAATCT GTTGACTITCA AGTAAAGGAG ATTGCTCTTG ATAGTATGGG TGGGCTTCAT CCAATCAATT GAAGGCCTTA AGAGCAAAAA GTAAGGTTTC CCGGAGAGAA AGAAATTCTG CCTCAAGACT GCAGCCTCAA CTCCTGCCTG AG'17TCCAGT CAGCCAGCCA GCCTAAAGAT TTGCTAGGCA TTATAATCAC ATCAGCTAAT TTCTTAAAAT AAACCTCTTT ATATATATTG ATACAATGAA TGGTrATAGC AGCCTlATTT GTAATAGCCA CAAACTGGAA ACAACCTAAA TGTCCTTCAA TAAGTGAATA CATAAACAAA TTGTGGTATA TCCACAA~rT TTACGCAGCA GTAAAAAGGA ATAAATGGTT GAATAAGGAA TAAACACATA ACAAGGATGA ACCTTAAAAC CGTAAGGCTG AATGGAAAAA GTCAGACAAA ACTAATACAT ACTGAATAAT TCCATTTATA TTGAAGTTCT AGAAAATGAG GACTAACCTA TAGTAACAAA AAGCAGAAAA ATT-rTGCCCA CTGGTGATGG AGGGGGCGCA GGTATTGTAG AGTATCTGAG AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACTTTTG AGGGTGATTG ATATGTTCAT CATATGTCAA AACATCAAGT TATACACTTT TAAAATGTTC GAGAGGAAGG AAGAAAGTGG GCAGGGTGGG GGAGAGGAAA

TATCTTGTGG

AGTTTACTGT

CATGGTTTCA TAGGTGCATA ATATCTAYI7A TACTT1CAGTA GGAAACGAGG GAGGAAAGGC CCTAATAGGA AGGATTTTGG AGTTTAGATT T-rATGAGTCC ACAAAAACCA CAACTCCCTA ATGCTTTGCC CCTrGCT"TAA ATGTAAGCCT ITAAACAGAA TGTACAGCAT TAATCCCAGC AATTTGGGAG AACATGGTGA AACCCTGTCT TCCCAGCTAC TCAGGAAGCT GATCAGACTA TTGCATTCTA

TTAAAATGAT

CCAGGAAGT(

TCTCTATGAC

TCTTFCCTCC

ATTATT[GTA

GCCGAGATGT

CTACTAAAAA

GAGGCAGGAG

GGCTAGGAGA

G3TAGGAAAAA

GTGGCACTAA

ATGTCCTCTC

TGGCTACTTC

CATTTACTTA

TCATTCAACA

ATAGATATGT

TAGAAGTATT

TJTAATGTTTC

ATGGACTTTA

CTGCCACTAT

TGCTCCTACA

TCTTCTGACT

AATTrrCrrC

TTATTGAT

ATAATGTGGT

CTCCTTGCCT

ACCTGAYTT

TTITTGGAATA

AAGCCTCCCC

CTTTAAATCA

CATAACCTAT

TATATAGAT[

ATATCTGTGA

AAAGGATGTT TGACACTCTA GGCATATGAC GAATATAGGA ATGTATGTTT ATACT-FTTAA GTGAAGGATC AGTGGATTAT TGGCTGCTGT CCTTCTCATC CCAATACTCC 17CCAAAGCC ITTCAACACA TCCTGCATTC CGTGACAAAA TAAGTTTTCC CAATTAAAAA T1TI1GGCCA GGTGTGATGA CTCATGCCTG GTGGATTACC TGAGGTCAGG AGTTCGAGAC CAGCCTGGCC TACAAAAAUT AGCTGAGTGT AGTGTGGCAG GTACCTGTAA AATCGCTTGA ACCTGGGAGG TGGAGGTTGC TGTGAGCAGA CAGAGTGAGA CTCGGTCCCC AAAAAAAAAC ACATTT= GGCTCTGACT CCTTAGCCTG GGCATCAGAG CTCTATCTAA TT1CCAT-FGCA GTACTTGTCC GCTCACTGGC CTGTGCCTCT TCCATCTTGT TTACTCAACT ATATCCAACC TCTAAGGCTG AGCCCACAGA GATATTTAAC TGCTCTGCAG TTCAGGACAT TATATGATCT TGTGATATTT 1TI7GTTGACG TGTTACT AACTCAACAA YfA3T[ATTA AATGCCAAGT TAGAAAAATA TTGAAATTTT ATTTGGCAAT CTGCAAGTAG AAAAATAATT AGTGCAGAGA CCATGGGGAA CATAATCCAG CCTGGAAGTT GAGCCTTMF CCTACAGGCA TGGAAGAAAC ATTAAAAAAA GTCTCCCAGC CTAGACTGTG GTGGTGCGAT CTCTGCTCAC TCTCCTGCCT CAGCTTCCCA AGTAGCTGGG ATTACAGGTA k TATTTC17G TTCTITTCCT CCTCAGTTGT CTTCCCTGAA CCCATTCTCA AGAACAAGGA TTTGACCA ATrTAATTTA AGTCACGAAA C'17GGTGATT AGAGACCAAT TCCCAAACAT CAGGAGAGAT ACGTGGAAGA AAGGACGTC ATTTTTTTTT TTGAGATGGA GTCTCACTCT TGCAACCTCT GTCTCCCGGG TTCAAGTGAT CCTGCCACAC ATGGATGATA AATATGATC GAAAGGAATG CCTTTTATAG ATGACAAAC'I ATCAGATGTC TGGC1TTTGAC CTAGAAACAC GAGCATrCT TAGGAAACAC AGTAAAGATC TGAGAGACCC AAGAGCAGAA GGGCGAGAAA CCAAAAGCCA

TCAGTTTGCA

TAT-rTJCTGA

CAGTCAAAAA

GACCTCTGAA

AACCACCACC

GTGTACAGAG

AATACTACAT

AGCAAGGATT

AGAATCTTTC

GTAAAGATAC

TAGGAAACAC C1TGTTTAGC CTAATCYFT-r TATTfrTTATT ACTCTA'ITAG TCACTACAAC TTGCTATGGT GATAGATGGT TTAAAACAAG CCUTCATTAA GAATTGTGAC ACCATGGTCT CACCAACATT TFTTAYITGGTA TTGACAATTA CTCTAAAT GAAGACTCCA ATCTTCCTGA ACAGAGAGTG GACTCTAAGC TAAGACTTAA AAGGAAGTAC ATCCAGGGGA AAAGAACAAT AGTCAAAGCC AAGCAGAGTT CAGAAGGGAT GGCTTCTAAA ACCTATGTAG TATCTTGGAC AT'FfATTCAT TCATTGAACA AATATTTTGA AGCAGTGAAT AGGACACATA AAATCCTAGA TGGGAATATC CAAYJ'CCAAG TCTGATGGGA AGCAGCTTGG AAGATAAGTA GAAATTATCC ACGTGCAAAA GTACGGAAAT CTGGTGGTGA AAAATACGGC CTTACCCTAA ATGTAATGAG GGCT7TCTGT GAAGAACATC TCTCACAGAA TTGACAUTCC GATTTCAGAC AATGGTACGT

AAGACAAGGA

CAAGATTACC

AGGTAAAGAT

GGTAAAAAGT

TAGAGAAAGC

AAGCTTFCTAA

ATTCTAAGTA

AGAGAGGGAA

ACTGTGAAAA AGGTAGACAA TAAATACATA AAATGAAACA AGGTAATGGA AACAAATCAT TTAACAAGAT

AGATCTCTCT

ATGTGGGGAC

GGACCAAAAA

TGGAATTATA

AGAGGAT7TA

TCTGGAGAAT

ATAATGGTAG

GTCTATAATA

TAGGTYTGTA

AAGAAAGAGA

AGAACTTTTG

GAAGGCCAGT

AGTAGAGCCA

AAAATCACTG

TAACTATAAT

CTTAGACTAG

GGTTFGGTTT

CCTGAGCAAC

C17TGTTTG CAAATTAAT1' ATTGAAAGGT AAGGGACAGG GCAGACAGAT CAGTTGAGCT AATATGCAAA ATAYJTACCTG GAGGATCACT TGAGTACAGG TGACAGAGTG AGAACCTGTC GGCAAATGCA TAGTATT[AA TGAAGGCCTA GGACTCTGGT CTGAGCACCC AATGAGGTGG TCAAAGAGGC GAGGCAGTCA TTFTGGAAATA TGATGAGCAC AACGAGAAAT GAGAAAATGT GACACAGAGT CTTAGCATGT TATrCTGCTT TTTGTACCTC TTC'n7ATCGC CTGAATGACT C ATGGATGGAT GGAAGACTTC GAAAGAAGAG TTTAGATrTTT AGATAATTTA TGTAATTGY[ AGCATITTG GTGTFTTCACT GAAAACTTGA AGCTCCTATT CTGTCAAGAA CAAGAAAATG AAGATTTGTT rrAAGAAGAC ACAGGGTGTI7 AGCTCTTTCC ATTGTTAAAT TCATAAACT[ CAGCGAAAAG GCACTGGAAG GAAGCCTGCT TACCTTTGCA TGGTTAGAAA CCACATGTGA GCTGCGACCT GAAGGATACC GAGAAGCTAG GTGTGCAAAG GACTGAATAG CAAATACAAA TGCCCTTGGG TGCAAGCTTr GCCTGTTCAA GTGCCTGCAG CATACTAAGC ACAGAGGAAA ACACTG'rrAT ATGCTGAGAT GATAATATAG TCTCYITATAG GTCATAATAA GGCAACCAGA TTTTATTCCA GAGGTTTTGC ACTAGGGTGA GAGGTGTGAT TTGTATTTTT AAAAGATAAT GAGGTAGGAG TAAACTAAGT TAGGGGCTAT TJTCAGTGGCT CAGACAAGAG GATAGTAGTC GTAGAAATAA ATAAAAGTGG CACTCTACTT TGGGGGTAGA ATGGATCATA TATGAGAGTA AAAAAAAGAA AATAAAYI7AA TAATGGTTCC TGAATAAATG GGTGCTGTGA ATTGAGATAA AGGAGATTGA GAATCACAGG TTGAGAGGCT TATTAGACAT CCCAGTGGAG ATTTCAGGTG AGTGGAGCCC GTCAGGTGTG GTAGGTCAGG CCTGTGATCC CAGGACYITTG GAAGGCCAAG CAGGAGTTTG AGACCAGCCT GGGCAACATG GGAAAACCCT GTCTCTACAA GGCATGGTGG CATATGACTG TGGTCCAAGC CACTTGGGGG GCTGAGATGG AGGCGGAGGT TGCAGTGAGC CAAGATCTCG CCACTGCAAA CCAGCTTAGG TCAATAAATA AATAAGAAAC GTAAGGGAAA AGGAAATTAA TCTGATCATT AGCCAGGGGA GTAGATGAGA TACTCAAAGT AGGTGAAGAT AAGGAGGCAA GTACAlTAG ATGGTTATAA GAGGAATAGA AACTGGCAAA ATAAGTAACA AGAGGAAAGC CAGGAGATGA AGCATCATAG AAGGCAAGAG AAGAAGGGTG TCAACTTCTG GGCAGTCAAA TAATATAAGG ACAGAAAAGT GACCATTGGA T-rTGAGTGGA GTGTTGAGAC AGAAGACCAA TTAGAGTAGA TTGAGGAGAT AACCTGCAAG CACAGACAAT TCTTGAGAGA CTTTTCTGTG AAAGGAAACA CTTGTCTTTC TATGGGAAAT GTAAATAGTT TGAGATCAGG GATAGTATTT rACATTACCT AGCATAGAGC TAGCTAATGT GCACU7AAGT ATGUTCTCAA ;GATGGGTGA AAGAATGGAT GGATGGATGG ATGGATGGAT GGAAGGATGG TGATTTGCCA AGAAGAGGAT ACTGGTAGCA GAAATAAAAA CAGCACTGGA TATTCTTTGG TGTCAGTTAG ACAGGAAAGT AAGACATTAG AAGAGTCCTT CACTTAGGAT TTITAAATGT GATCACTGAT ATTGGACATG TTCCTAGTGA 3GTTGAAGTT AATAACTGTA AAA31'ATTTC CCGTTCAGGA CAGAAAAACA

CAATGGACAT

CATCATITTGC

TTGAAATCCT

TCTCATCTCT

TCAAAGATAA

GGCCAATGGC

CACCTCCATG

TAAAATTTGC

TGCTCATGGT

CATTTATATG

ATTTATAAGC

AAATGAGTTC

CCTTTTCCAT

ACAGAAAAAA

CCTAAGGGGA

TGGGAAACAG

ACAGGAAGCC

TCAGTGACCT

ATACTITTTAG

TGCATCATGC

AGAAAGTTCA

ACCTGTATAC

ACTT[CCATA

TfCCAACCTC

ACCAAGGACT

CATAATGATA

CCTTGCCCAG

TTTTTGTGTC

AAAGTGATTT

GAATGCTGTC

GTATGAACA(

TCCCTACTCT

TTTATCTAAT

GAGATTGTGG

TAGGGACTGG

AGAYFCTCTG GGGTTCTTAG TTAACTGGTC TAGGCAACAG GGAATCAAAC AATAGCTTrC ATGGCTGT-rG TACCTTACCT AACCAGCCTC TGGGGAATTG ACTGACTAAT AGGAAATACC GCAACTACTG GGGAAAATGT

GATTTACTGT

TGGAAAGACA

AGTGACTAAC

TTCGACCCCG

CTGTATACTT

CTCAACTGAA

CATGCAAGCA

TCCCAAAACT

ATTCTCAGAG

ATGGTAAGAC

TGYI7CCTGAA

AGCAAACTTA

AATGAGAGAT

AAATTAATCT

TTCCTTTTCC ATAGGCACCA GAAATATCAT GGTGCCTGGA GATAAACTGA TTTATATTGT GTCCAAATGT GAYJ7GTATTT TGGCCCAACA GCAGGCTCTC GACTTCATTT CAGACACTGT TAGGTTTCTG AGTCCCCTGG AATTAT-rCCA TTI7ATGTAGC TACTTCCCAG TTTGTTCATT CATGGCACCA GGTITGCAGAT AATGTGTTAC CTTCTTCTCT TAAAAAGTAC AAGGGACAAA CTCTCTAT7A ACAGTATTTA TI7CAACAAAC AT117ATTIGAG AACCTAGTAA GTGTAGCACA TA1TATTCA TTI7AATCCTC ACAACAAACC CATGAGGTTG GTTTTATGAT CCCAATTT CAGAAGAAGA AACTGATATT CAGAACCAGT TAACTAACTG GTTCAAGGTC ATGCAATTTC TAAGATACAG AACCAAGAGT CAAAGACATG AT1TTAAACC AAAGCYT CTGCTACTCC ACATTGCTTC CCTAGGTGAG ATCTGAGGCA TTCCGCGAAA. AGAGAAGGGT CATAAAGCCA AGGGAAGACA AGCTTAGGAA AAAAAAGGGA AATGTCCTAA ATAAACAGCT TTCCTATrTA CCAGAAACCA CTAGTTTAAA AATATAATGG GAAAAATCCT ATTCACTTTA ACAATGTTAA AAAAAAAAAA.

GATAGAAGAA ACATAGGGAT AAACTTAACA CATTTGTAGG ATATGTAAAG AAACTAAAAG ATGTTFAATAA TGGCCTAAAG AAAAAAAAAC TUACATGTAT GGGGAGATAG ACCATCT-FAC TGGATTrCTAA TAYT 1AATAG TCTAGGTGTT CCATTTCTCA CCAAATTAAT GTATACATTTF AATACAATGT CAAACGAAAT ATCTIT AGGAA T7GCTTACAA ATTGTCAGAT AATTACAAAG TTTrACCTGGG AAATATAAGC ATATATGAAG AGTGAATGGG ACCCCACCAC TCCCCCCAAA ACAAAAAAGG TCTGAAAAGG ACAGAAATCA AGGAGAGTCT TGCCTGCCAG ATACAAAATT CTATTATAAA GGTGTATTGA TGAAAACAAT 'ITAATACTAG TGTAGCAATA GGjCAGCAAAG CAATGAAACA GCATAAAAAG ACCAGAACTA TACCTAATTA TGATGAAGAT 7rrAAGGTATG ATAAACATGA CATAATTCAA ATCAGCAGAA ATTGGCATAG ATAGGGTTAA GACAAATAGC TAATCATTAG AGGGGAGGAA GGAAAGGAGG GAGGATAAAA TTAGGTTCCT GCCTTCATCT TACATTAAAA TAAATTCCAG ATGTATTACA TT1TAAATTTT TT7AAAAAAA GAAACCACAA AATACTTGAA GAAAATATAA GTTGTTATAT AGTC1TITTGA TGGGAATMr TTTrTTMfC AGAGACAGGG TCY[GCTCTG TCACCTAGCC TAGAGTGCAA TGGCATGATC ATGGCTCACT GCAGCCTTGA ACTCCTGGGC TCAAGTGATC CTCCCAGCTC AGCCCCCCAG GTAGCAGGAA CTACAGGCAT GCGACACCCC ATCCAACTTA TTTTTATTT TTTGTAGAcJA CAGGGGTCTT GCTTTGTTTC CCAGGCU-AT CTCGAACTTC TGCC'FrCAAG CACCTCAGCC TCCCAAAGAG CTGGGCTGAT GGGACATTTT 'I1AACATAGT GCCACATTAC CATAAATGAA AAGCTTGTAA AATACTAATT YrTAAAACTA ATATATATCA GAAATTTTTA TAAACAAAGT TAAAAAGCAA ACACAAAAAA TTTGTAGCAC TTATGACAAA TATATGTATA TATATGAATA CAAAAAGAGC CTTTACAAAA CAGTAAGAAA ACAATGAATA CTCCCAATGG AGTATTCAAA ACTAAACTGC TAAAAGCAAT TCAAAACAAA AAACATAAAC TATGCATATA TGTATGTGAA AAAGTTTAAC CTTATCAAAG AAGTAAACTC TCAAAGAAAT AAACATCAAA TAAGGAAATA GCCTTTfCCC ACAAATAACC AAAATCTGTA AGAATACTGA GCTGCGAATG 1TTTCAGAAAA AAAAAAAAAT CATACACCTA GTrCGGCATG TAATTAATAT AGATCAGAAC ACTTTAAAAA TATTTATAGG CCAGGCACGG TGGCTCATGC CTATAATCCC AGCACTTTGG GAGGCCAAGG CGGGTGGATC ACCTGAAGTC AGGAGTTTGA GACCATCCTG ACCAACATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ACTAGCCAGG CATGTTGGCG TATGCTGGTA ATCCTGGCTA CTCGGGAGGC TGAGGCAGGA GAATTGCT[G AACCCAGGAG GTGGAGGTTG CAGTGAGCTG ACATTGTGCC ACTGTACTCC AGCCTGGGCA ACAAGAGCAA AACTCTGTCT CAAAAAATAA TAATAAATAA AAATAAAATA iTTTATATACT CTGACCCATC AATITGTCCA GCATAATTAG GCATGTGTAC AAGGGTTTAC ACACAAGAAT GCCTATTGCA ATATTGCTTT TAATGCTAAA AAAAATTGGG GAAAATGCTT TAAAAATATA GATTAAGACT GTACATTGTG GTACAGTCAT ATAATCAATA GTATACAGCT ATTATfTATT TTCAGCCACT GTCCAAAATA TAGCCTGGCC TAACAACAIT CTGTTAGGAT ACGCAAGCAC CGTGAGGAGA TCAGCTATAA AGTATCAGTG YTCACACCA CTGCTCCMT GCTAATAACC TrCAATGGCT 1TrTAAAGAAG TAAAAAACAA AGGCAAAATT CCTfAGTCAG CCCTTAAGAC TCTCTGTTAC TTAGCTCAAA CTACCCTTTT CAACAACACT GCCCTAACCA

GGATGAGTTT

TCTCCAGGAC

CTGTCCTAAC

AGGTAAAAAG

CTGTCGCCTA

CCTCCCACCT

TTTAITTT1TT

CTGTGGCCTC

CATTAACATG

TAAATGCGGT

TCTCATCAAC

ACATTAAAAA

TTTGCCCCCC

CACYJTCACTT

CACTCAAACC

GTTrTTTACTG

GAATGGGGGG

CAGCCTAGTG

3TGAGATGGA

CCAAAATGCT

AGGAACAGTG

TGATGGGTTA

AATCAAAATT

ATTCCCCCAG

TGGAGTACAT

TCTTCCCCAA

CTAGCTT1T[

TTTATTACCT

AAGTGGTGTG

AGTAGCTGTG

ATCTCACTAT

GGGATTACAG

YJ7CTTTACAC

ATCAATGTGT

GAGTAAACAG

CAGGAGCCAA

GGAAATTTGA

TGCCAAATGT

ACCGTCAAGT

AGGTACAAGT

AGATCCCAAC

GGAGAAAATC

TTCAA6CGGG

TGCTCCATAC

TCAGCCTTFTC

T-rTAGCAlTIT

CTCTGAACTG

ACTCAATAAA

ATCACAACTC

ACTACAGGCA

GTTACCCAGG

GCATGAGCCA

TATTTTATCA

GAAAATATTC

CTTATCAAAC CTTCC17TAA ATAAGTATCT TCTATATCTC CAGGCCTACC TCTATAAAGC

CTAGAAATAT

AATT[TCTTT

ACTGCAGCTTF

TGTGCCACCA

CTGGTCTGCT

CAATATCTGG

GCTAGGGCTT

AGAGCCACCA

T1TCTCTCA TTGGCCATT YTTMGAGACA AGGTCT-[ACT CTACCTCCCA GCTCAACAGT *TACCCCACTA CTTTTCATTT GATCTCAATT GATCCTCCCA CCCCAGTAAG CTTTTAAGGC TGCATGGAGT AGGAGTTTAG AAAACAGATA U-ATGTCTAT CCACAAAACA TTGAATGGTG CAAGTITAGCA AACTGCAAAA GGCTGTCTTG ACTGGATCAC CCA'TTrCTA ATACAGGAAA CCAATTT1TTT CATCCTGATC GTAGAAGCAT TTCTTATGAA GTGTGTTTAT GCTAATCCTC GATAGGAAGC ACTAATGAGT AT1TTTAT-rG CTGTTGGAGG CACCTCAGGC

CAAGGATCCT

CTAGGGAAAA

GTCATTAATC

CAATTTACTA

T1TAAATTTAG CTCAAT-rCCA

TCCCTCATTT

CCACAAACTC

ACTGCCTATC

ACTCAAGGCC

AATTAACAGA

AGAAATGCAA

GGAAACAACA

TAGTTrCAACC

AGCCATCCCA

ATGTFATTG

GGATTAAGAA

ACCAAGTGTT

GACATATTCC

TCTCTTCGTT

GATCATAGTT

AATTGCTAAC

TTCATGTGAC

TTAACTGATG

CTACTGCCTT

TGTGCTTCTA

ATTGCTCTAG

GTAGCTCCTA

ATCAAAACCA

GGTGCTGGAG

ATTfGTGGAAG

TTACTGGGTA

GTCTGTTGGC

ACTCCCACT7

CCTGTTTAAA

TACAAAGCCT

CCCYTATGCG

CCTTCCCTCT

AGCTCAAGGC

TGATGCTACA

TCCCACTATC

TGCTCCCfT

ACAGTATGCC

CTC1TCATAC ATCTTGTTFC CTATTTCTCT GAGAAAATAG ATCTAGCCCT GTACCATATA CTTI7GCAIT-r TCTAAGGCTA ACCCYTFCCAC TTCAGTTTTG CAATTCTCTC AYJ7CTCTCTC AT1TTTCTTCC AAGGGAAAAA AAAGTCTTCT TT'rFCAATGC CAATGAGATA TCATCTCACA CCAGTTAGAA AGGATGTGGA GAAATAGGAA CACTTTTACA ACAGTGTGGC GAT-rCCTCAG GGATCTAGAA TATACCCAAA GGATTATAAA CAATGCTGCT

CCCAGCGTTG

GAGGAGTTGC

TGCCTACTCT

AGATTTAAAC

TGTCAGTCAT

TACTATTATC

AAGCCATCAA

CCTCTCATTA

AATATTATCA

ATCAAGTTTT

TCATCATCAC

TGGCAATCAT

CTGTTGGTGG

TITAGAAATAC

ATAAAGACAC

ACGTCCAACA

AAAAATGATG

AACACACAGT

TTCCCTTGCA

TGAACT'TGT

GGGTCTTCAC

AGGTCTCCGT

ACTACATTTC

TCTTCCCCCC

AAGAGAGTTT

CCATGGATGT

GCTCTTACCA

CCT1TI-CTTC

TGGCCATCAG

TAAAAAGTCA

GACTGTAAAC

CATTTGACCC

ATGCACACGT

ATGATAGACT

AGTTCATGTC

TGGCACTACT CACAATAGCA AAGACTTGGA ACCAACCCAA AATGTGGCAC ATATACACCA TGGAATACTA TGCAGCCATA CTrTGTAGGG ACATGGAGGA AGCTGGAAAC CATCACTCTC AGCAAACTAT CACAAGGACA AAAAACCAAA CACTGCATGT TCTCACTCAT AGGTGGGAAT TGAACAATGA GAACACTTGG ACACAGGAAG GGGAACATCA

CCCACTGGGG

TGATGAGTTA

ACATGTACCC

T-FC1T=CT

GATCGTTCTC

TACTCTAACT

ATATCATTTA

TGTCACCTAG

TCCCCCTGCC

TrTTTGT-TTG

CCTGTGTGG

ATGGGTGCAG

TAAAACTTAA

GCAGGATCAG

CAGATCCCAC

AGTTACATAT

TCATTT[CAC

GCTGGAGTGC

GATGAGGGGA

CACACCAACA

AGTATAATAA

TCCATCACCA

TGCTCCT-rCC GA1TTTCTGTC

TCTAAU-GCA

AGTGGCATGA

GTGGGGAGGG

TAGCACATGT

AAAAATATAT

CACACACAGG

AGTTGTCACC

CCCAGGTCCC

CAACCAAAAA

TCTCGGCTCA

GATTATACAC

ATAGCATTAG

ATACATATGT

ATATATATAT

CTGTGTTA

TCAGTTCTCC

CTCCCTCAGT

CTCCCT[TT

CTCCAACCTC

ATGCACCACC

GAGATATACC

AACAAACCTG

AAAACAACTA

TGrrGTTCCC ACrCTrTTT TGI=rGAAC Ti=AGATOG

CGCCTCACGG

ACACCTGGCT

CTCTGTTGCC

TAATGTTAAA

CACGT"YGTGC

AAAATAAATC

CAGCTTAAGA

GCTGATAAAC

ATAATCATIT

AGTCTCACTC

GTTCAAGTGA

AATTGCTTTG

CAGGCTAGAC

TrAGCCTCCT GAATAGCTGG TGTGTGTGTG TGTTTIT TITITTF-GGA CAGAGTCTCA 99 TGCAGTGGCA TGATCTCAGC CCCGAGTAGC TGGGACTACA AGGTCACC ATGUTGGTCA AAAGTGCTGG GATTrACAGAC TCACTGCAAC CTCCACCTCC TGGGTTCAAG GGCATGCACC ACCATGCCAG GCTAATTT GGCTGGTCTT GAACTCCTGA CCTCAAATGA TTGAGCTACT GCGCCGGGCT ATTYITGTGTT

ACCATGTTGT

TGGGATTACA

ACATTGTCAA

TCTGTTCCTC

CTCAGGCTCC

ACTTAAGACA

CCATTTCCAG

CTGTGCAGGA

AGCTGAACTC

AACATAAATC

CTGAAATATT

ACTCTGTAAT

CCAGGCTGGT

GGAGTGAGCC

ATCCAGTGGC

TATCTGTTTC

TTTGGGGATT

TJ7AAGTGGTC

TCTGACTGTT

AATTGGACAA

ACCAAAAATA

AAGGATACAC

CTCAAACTCC

ACCATGCCTG

ATTCATCTTA

CAGTATACTG

TGAAGGTATG

AGTTCCTTTA

CTGTGTAATC

ACATTJTGCAC

ATTTCTGTAA

AGGTAGATTT

TGACCTCAAG TGATCCGCTC GCCATAAAAC TGCCCTTTGT CTCGGCCAAC CTACGGCATT GCCTGGCTTT CTTITTACCT TTGCATTTTG CTATTCAATG CTAGGATAAA AATAATTTI'C 1TTGTATTCC TTGGCAGCCC TGGTATAACC AAATACAGTT GAGACTGAGA CGTCTACGAG GAAT1TCAGA TAAACAACAA TACCTGGTAC AGAACTAATC.

GGAGGTATTT CTGTAATTAG CGATTCTCCT GCCTCAGCCT TTGTATTrTC AGTAGAGACC TCTGCGCACC TGGACCTCCC TTTAGTAAAG ACGGGGTTTC GCCTCAGGCC CTCAAAGTGC TAATATGACT GTTGGCCTGC TGACACTGTC TGTCTCCT CTTTTATATG CTCTTCCAGT AATAATGACA AGTAATGATC TTCCCAACAT GGGGCATATT CTITTATATC AGTTCATCTA GAACTTT7GG CTTGACTCTT TAGGTTrTTC AGAAUTAGTA ATACTTT1T AGTATGTCTA CATTCTCTTG AAAGATCTTG AGTCACTGTC TTCCTCCCAG GGATGAAGAT GGGTGCTTTG TGTATCTTAT CTGGCAA~rC AAGTTCTTTG GTGATGGAAG TTTTrATCC TGGCCCAGAT CTGCAATGAA CACACGACAG AATCCAGGGG CAGGAAAAAA AAATTAAAAA CATCTGAAAA AGCTTUTGTA CTAAAAGAAT GTGATCTAAA AAAGAAAGCA GGAGAACTTFr CTGTCTGCAC TTTACATCAG AACAACCTTG GCGTCTAGAA GCTGTGCCCT GTGGGAAGTG GTGGTGCTTG GTAAGAGATG CCAGGACCAG TGGTACCCAC TGGGAGCACT GCCAATACCC AGCAAGGAGC ATGGGTGCAC AGTAAGGCAT TGCACTGTGA YI7CAGCATAA AATAACAATA AGGGAACGTC ACGGAGAAAA GGCCAGACTT CC'FTG1TTA GAATGTGGGA AATGTCTTCT GAAAAATGGT AGTAAAAAAG CATGCTTGGA TGGTCCACTC CAGGCAAAAC TGACTAATCG GGGGTCAGGG ATACAACCCC TGCATCATAT GTT-rGTTTCT GTTGGGCTGA CATGAGGYFC ACTGTGACCA CTGTGGTTTA ACCCCATAGT CTCCTGGAAA TACAGCCAGG TCAAGAGAGC TCCACATAAA ACATAATCAA AAAAATAAAC TCAAGTTTCC ACTGATCAGC TTTTCACAAC TCTTATCCTfT TCACTAACUT TGGAGCAAGA TTAGTTCAAT GTTTTGU"CT TTC1TATTA AGGGTACATG TGCACAACGT GCAGATTTGT TCAACTCGTC ATTTACATTA GGTATTTCTC CCCTGGTGTG TGATG11TCCC CTTCCTGTGT TGTGTATGTT GAACCAGCCT TGCATCACAG TTATGTGTGA TAAGTGAAAT CCAAGGATTT TTCCTTCAAC CATGAGTGTA TGCAGGTrTTT GCTGGCGCGC AGTGGTGCGA TCTTGGCTCA TCAGCCTCCC AAGTGGCTGG GATTACAGGC AGATGGGGTT TCACCATCTT GGCCAGCCUT CCCAAAGTGC TGGGATTACA GGCATGAGCC AAAAAAAAAA AAAATTTCCC AATGAAATAT ATGCCAGTTT TCACAAGTGT CTATAGAACA ATGGCAAATT TAAACAGGTA TACAACAAAA CTCTCAGCCA AAGGAATACC AAAGTAAACC AAGCCCAACA TGACTCATTA YTCTCTCCTC TAAAACACAG ATCTTAAGAC TGACAAGCCA

TTTGAGAATT

GAGAACTATG

TACACAGGTA

CTAATGCTAT

CCAAGTGTTC

TCACTTGCTT

ATGCTCAGAG

TCTTTI7CTT

CTGTAACCTC

ACCTGCCACT

GTCTTGAACT

ACTGCGCCCA

GGATGGCTAT

GTTJFMTATT

TAAATGTGCC

CCCTCCCCCA

TGT-T7ATGTG

ACAAGAAACA

GTGGGCTTAA

TTTGAGATGG

TGCCACCTGG

GTCTCCGGCT

CCTGACCTCA

GCCCACAGGT

AAAACTAAAG TGCTAAACTG TGTAATTTrAG

ATAAAATTCT

TGAAAAACTA

CCT-17GGAAT

GACTCTTTGT

TATATTTTCA

TCTTTCCAAG

ATAGGTAAGA

AAGCCCCTCA

GTTrrGGTCCA

TCAGGCACAA

AGCAGAGAGC

AATGGCCCTG

TTTTTACTGA

TCTTGCTCTG

TCAAGCGATT

GTTATTTTAT CCCAAAAAAT ATJ7TCTTTGA AATTTCCTTC AAAATTGACA

GAGGCTAGCA

TGGCGTGATC

GTAGCTGGGA

ACCATGTTGG

GCATTACAGG

AGAGGC117CA

ATTCCAGGTC

GACTUAAAAG

TGATGGATAT

GGCACATGTT

CTTrCTTTAAA

TCATCAGTCA

TAGATTGCTA

TGCTGTACAG

TGTTTTT-T

TCAGCTCACT

TTACAGATCC

CCAGGCTAGT

CGTGAGCCAC

TCAACATAAT

TTTAGATAAT

CCCCACTCCT

CTGCCTGTAA

TTCAGGAACT

TTITTTTTT TGAGGCGGAG

TTGAGGGCTA

ATAM~ACAC

ATGT7GGYTT

GTCCCCCACC

ATAGATTACG

AACACTTCAC

CAGGTAGGAA

AGTCTCACTC

G1TCAAGCAA

AATTTTTGTC

TGAATCATCC

TTrTTCAAAGA

TGATAGACTG

TGAAATTTTG

ACCAACTGAA

3GATTGGGGG

CTGAATGTCA

CAGGCCCTGG

CAAAGCTGTC

TCCAGGAGAG

rTGCCCAGGC

CTCCTGCCTC

TTTTGTAGAG

CTCGGCCTCC

TCTCTCTGAA

TATCCTATTA

AAGTCTTTGA

AATGTACACC

GCTGTAACCC

CATAT'ITGGC

ATAAAGAATT

TGATrTGTAG

GAAATGCAGA

TATTGAACTC

T1TCACAGA

GTCTGATTAA

TGGCCCAAAG

TATTAGTTGT

CCTTTGGGGT

TACGAGATTT

TG'FrCTCTCA CTC1TrTGATC

TTTCTGCGCT

I1TTAAGTTCT

GCTGCACCCA

CCCCGACAGG

TTTATTGATT

AGATGGATCA

GAGCAGTATT

TTTTACCCAG

TTCTCCTGCC

YITTTAGTAG

TTFCTCAGCCT

CTAAACTTAA

T1T[ACAAGA

ATAATATTTG

TGGACTCCTTf

TAGGTGGGGG

GCATTGACAC

AAGAAATCAA

TCTTGTGGGG

ATTAACTAA

TGGAGTGCAG

AGCTITCCCGA

ACAGGGTTTC

CAAAGTGCTG

GCTACTATCT

GTTTCTACTG

ATCCACCTAT

TrATATGTGT

AACCACCYTG

TCACAGTAAA

GGAAGGTCTT

CTTTGCTACT

CTrTCCTCCT

CTAGGTGCAA

CTAGTCT-TTC

AATCTGCTTA

GAA1TTCTCC T7TTCATATA

TGGCAATGGA

ATGTTGCTCA

CTGTCAGGAA

AAC1TTCAAA

GCAACCTTCG

ATGCCACTAT

ATTGAkACTCC

CGTGCCCAGC

AAGACCCTTG

AACAACTCTT

TCAAGTTATC

CCTCCCGGGT

GCCCAGCTAA T1TTTGTATT TGACCTCGTG ATCCGCCCAC ACAAGACAUT TACCGTCTAT GTCTCCACAA CTCCTTATCT TCAACCAATT GCCAATCAGA CCGCC=TCT GGACTGAACC CFCCATTCC CCTAAAATGT ATAACATCAA CATGAGACTG TGTTGCAGAC CTTGGTCACT TATTGTATAG AGTTTGGCT[ T11TTCATTGA CACAGGAAAA CTGAGCCAGC YI7CATATCTG TCCATTATCT AGAAGCATCA AGAACCCAGG ACCTTGGAAT TTCATTAATT CATGAATTAA TGCCTCTITAA GCACTCAGCT CATGTGAGTC TGAGATCAAG TCTATYITTAG CACTGTCCCA TATGTTATTA AGGAAACTAG GGGGAGGCTC TTCTTGAAAA ATTCYJ7GGCA

TGAATTAACA

CACCACGCTT

TGTrATCTCT GTTGAC'FrGT

ACTGAGGTCA

GGATCACGTG

CATAGTAGGT

CGCTCTCAAA

CCAGTCTCAC

TCTGAGAAGT

CATITATTCTA

TACAGTTCAG

GGACCTATTG

GCTCAATACA

GT-rTAGTGCT

TCCCCTATTA

CTTCCCTCAC

GTCTTTFTTCA

TCATrTCCCC TAATAGAACA AAATTGCTGG GGGGGAAGAG TGTrCTCCTA ATATTTTTCT TCTTrAGCCT 'FrAGTCCCCC ATrGCCTGCC TACAGTTGGC AGAGACCATC CTGTCTCAAT TCTTGAAGTT CAGAGTCAAA AAAGAAGCAA GTTCCTAG 100 GTTTTACTTC CATTTGAAAA TTTACTAAGT CACCAGGAGA TGGT-rTATAC TGAGAAATAT CCACTCATAC TCTTCCTCT-r CAACTTrCTT CCATATACAC CCTATTACAG ATGACCCTAT CAGAAACCTG CACAGTATGT AAAACATTCT TAGAATGGAA GCTCTACAAA AGCACAGAAT GTATCATTTT TTGACACATG ATTTGAAGTT GTTATAAGAA TAAGAATAGT ATTTTTTTGC GACAGGTTCT

GGATATAGTC

CACCAGAGGT

AACTTTAGAT

TTGYITTTAAA

AAGCTGACCA

AGTGGAGTGG

AATATTTAT[

G11TACAGAAT

CGCTGTCTCA

TATCAAGTGA

TGGTATACAC

CCCTGGCTGG

GGTTTGAACT

CCACCATGTC

GAACTCCTTG

ATGCCTGGCC

CTCAAGCAAA

CAACTGAGGT

GCCAACCCTG

AGTTCACAAG

TCTACCATTT

TCTCTATCAT

CTI7TAATACA

CGTTAGTTAA

AGTCACAGTA

T-TATAGGAGA

TCCAGGCTCA AGCAATCCTC CCACCTCAGC CTCCCACATA CAGCTAACTT TTTAATTCTT TGTAGAGACA GGGTCACCCT GCTAGAGAGA TCCTCCCTCC AAGGTCCCCC AAAATGCTGG ATAATCAATA CACTrTTAAG AATGCTAGAA TGTrATATCA CTGGGGTGTG GGTTATTCTA CATATAAAGT TCAGCAGTGT CAAATGTAGG GTGCAGCAAG GTCACTGGGG CTGTCATCAA TTTCYTTGATT GTCTCTACCA CCATGAGTCA CCAGCAATCT TATTGTGTGA ATTGCAGGCA ACCCCTTGAC TCCCTGATTG TTTTCCCCA GCACTCTrC TGCTGCTCTA AA1TTTAATT TCTTCATCTC TTTCCTCTCC C~rCCATCCA ATTTTGTTTG TTTCTCTTTT TCTGAGAAGG CTTGAGTCCA AAACTCTCAG TTACTCTATA GCTCAAAAGG TCACTfTGTGT A17TCCACCC TCTATTTTCA CACCCAGTGC ATCATGACTC ACTCAACAAA TAATCAACAC ACCTATTATC CATGACCACG GTTCACTGCA GCTGAGCCCA CAGGTGTGTG ATGTTGCCCA AGCTGGTCTT GATCTCAGGC AAGAGCCACC GATGCATACT TCAGCACTAT TGTTCCACAG TCCCAAACTC GGGCCTCTCC TTGCACTCTT CCCACAGTCA CTTGTT-rAAA CCTGGTCTTC TTFCCTTGGGC CATGCAATTC CATATGTGTT TCTGM~GCT TGCTTGCTTG YJ7ACCTGTTG TJTCTGT1TCC TCTCCGAACC T-FCATAAATT AAATCTGACA AAGTCCCCTG ACTAACAAAG GAAATGCACA AAAGGGGCAC ACACAGAACA CAAATAGACC CAGGGTCTTT TCTGTTCATC ACTCAGCMfT TCCAGGAGAA ATGAAGTGGA AAGGGAAGTG TGTTGAGTTA CTATACAACA CAAGAGTAAA CTrCTTATA AGTGGTAATr TTJTTTJ7ACA GGAATAATTG AAAATGGAAA AAGTACTCAG TGCGTTCTTG ATGGGATGAG AATGTGTTTG AGCTTTAGTG TCTGCCAGTA TrGGAGAAAA ATAAAACACA AAGGGACTGA CATGTAGGAA AATTCTTCCT ATTACAAAAA TGCCCCAGAG AAATAAAAAG CTTGTGTACA CTGGCCCCCC TCGCAGGATG TGTGACAGTG GGGTGGCTCT CTGCTGCGCC ATAGGAGGGG GAGCACACAG GCAGGAAGGT GCAGGAGCTG GGCGAGCTCT ACTGTCTAGA GGTGGGTGCC TGCAACTCCT GAAAGCCCAA GTGGGCATGT CTTTGCTGTC TGCAGCTTAA GCGTTAACCA GCTCAGYFTC TTCTI'GGTAC CAGGAAGAAT CAGGTrACAC ATGGACYI7GA AGGATGAATG TGGGAGTTTT CTCAGTGGGA TGGATGGGGA GCTGGAAGGG GGATGGAGTG GGAAGATGAT TCCAGCAGCC GATCTCCTCT CCAGTCGTCC CCAGCCTCTC GACGTTCAGA CTGCCATGCT GTTCTGCCGT TCATCTGCCT GTCTCTCTCT GGAGCCTGGA ACAATAAGGG GCATGGCAGG CCAAAAGGGA ACFTTTAGG TGCAAAAAAC AGGGCTATAG ATTTTCAGGC TTGAAGGTGG GGCCTTTACC AGCGAACCTG ATATCAATGT AATCAAATAC TGGGCTGATC CAGGATGTTr CTTTAGACCA CATTCAGGUF TTFrATATTTG CYT-MGTCAT TTCTTTTTAA GCAATCATGT ATAGATGATA GCGAACCTAA TTAAAATTAC CAGAAACTTA AGAATCTCTA

TTACCTTCTC

TAAGGCAGAA

GTGGCACCTG

TGTTGAGATG

ACCATGAGCT

TTGGGCTCTG

GTTACAGTGC

CCAGGTCCTI7

TACTCATAGT

TTCTGTTTAG

GGAGGGTCTC

GGAGAGTTCT

CAAACCCCTC

GCCCCGTGGT

ACTCT17ICAG

GTCTGGCATC

ATGGAGTGGT GGAGGTGGCT ATTCTCCTGG AGTTTGGCTG TGCTCCTCT7 ATTTrGGGGTT

AGGAATGCCT

TATTTCCCTG

ATTATGGGTA

AAAATATCTA

ATGATTTCAA

TCTGAAGTAT

CTCTCCTTCT

TATATGGTAC

CT-rCTCAC'rr

TCTCCTGTGC

AAATAATTTA

TACGACAGTA

CTGTAACTAA

TTCAGAAACA GGTTAT'FrCT CTTTATGTTG AACAATGTTrG GGAGATAAGA CACAAGAGTT

CAAAGAGGGA

ACGAGTGGTT

ATATTCAAAA

AAAAATCCTG

GGTTATATAA ATAATATTTIT TTTCCTAC17 ATTTTAATAT TTAAAATACA GGCTTGGATG CGTCTGACCA CCC'rrCTAAG AAAATGCATC GAGAAGCTTG AACACAGCAA AGCAAACAGG TGGGAAAATG AAAGCTAGTC ACAAAGTTAA TAMflCCTGT TAAAGAAAAT AAAATGCAGA TCTGAGGTAT TTTTCCTTAG AAGTTAYITGT ATGCAGAGTT TAATCTGTGG AAAGCTTAGG GAAGAAAAGC AAATCATTAA AATGATAATA AAAAAGCTGG TGAATTTCTA GGCATTAGTG ACTTYMTCA TGCAATFrTAA AAAATAGCAG AGATCTAGAA AAGTCTTGAC CAGACATGAC TCTTACAGTG GACAAGT'rrG GATCTGAGAG GTGACTGAGC TGGTGGAGAC CTGCTGGAGG TAACTGGATT ATGTITAGAG AACATCTAAG GCTCTI7GAAT GATGCTTTCC CTGCAGGGTG TGCTTCTGTA GCCCTAATTT TTAGTTAGGC TCTGGGCTT AGCTCTGCTA AGTCAGTTTA GCUTGTCTTC AGCGAGAATTF TAGTATTT TCATCCACTG TCTGCAGTTA AGACTATTTT GGTAATGAAT AAAGTCTGCC GCTGCACAAT GAGATTACTA GTGAGCACCA AATCATTGTG TGTGATGTAT GTTACATAGT GGAAGACTGT GGAAGT1TrGT AAATAGGTCT TCCTCTGAAG ATTTAAAA CGCAAAGAGG GTGGAATAGC CATAGAGAGT GGCACAAIT GCTGTGCCAC TGAGCTGACT GGATGTGTTC TACCTTTCCA CACGCATTCT CCC1TTAAAA AAAATGCCCA CACACTGAAT AATAAGCGCA CCATCTAGTT TACAGAAATT CACTAGAAGT TATTTATCCT GAATTTTGAG CTCTAGGACA TTTAGACAC ACAGAAAGAA GAATCTGGAC AGAATAGAAA TTTCTTT7CC TA1TTrATCTC TTFTGAATAAA AT-FTTCAGGA TTATCTACAC ATUGTGAAGC ACATTGATTT CTCCTCTGTA GCCTTAGGAA TGATTGAATG ATCCGTGACC GCTCTACTGG GACCAGTAGT AGAACTTTAC TTTGAGAGCA GACTTTGAAA ATTACTAGAG CTACACAGAT ACTGTGTGGC GCTFTTCAGAA CTATGCTGCT GCTGCTGCAG TGTAGCCAGG ACGCACAGAG GGGGCGATAG GGACAGATTr CAGCAGCCAT CTGACTTCAG TGCTCAT1TT

CAGTGTGCAG

CCGGTTCAAA

TCTC117ATGC

GCAAGAATCC

CTATTAGGTTr ACTCCYI7GAC

CTCCCCACTA

TYFACCATGCT

AAACTTTATT

TGTGCAGTGT

CTCTGCATTC

CCACCTGCAG

CCACCTCAAA

CTGTTAGATT

CCACCTTGCT

CTGCAAAATC

TTAACAAGTA

CCATTTTGCC

GCAGTGGTGG

ACCTTGACAG

ACTTTTIGGT

AGTCACTATC

AGAATCCTCC

CCTCGGCTAT

CCATTGCCAT

GAGGCTCACA

A'ITCTTTCCT

AAAATCCAGT

TCCCTCCCTG

TfACCCTTFGA

AAATTCCCAC

GGTCCCTATA

CAGGAATACT

TGGCCAAAAT

1TTAGTAAAG

GTAGTGTCTG

TGCTTCCTCT

TTGCCCATAC

CTATCTCAAT

TTAACAATCT

AATGGCTCTT

GTATGTTACA

CTTFATCAGTT

ACATTGAACC A1TTTTTCT ATGCTGGATG TCCTCAATGG ACAGCCCCCT GTAACGTGAT TITI'GCCCAT 3T7CCTATAT AGAAGGAAAA CCCATCTCTTr 1TrTTTCAT GTTGATCACT AGTACTAAGC CACAAGATGA CTAAGAAGAG YrGAAAGGGC AAGTGGGGCT AAAAACAGAT 1TTGTTTGAC T7ACCCCACC ATfCCCCCTA TCATGGGGCT GAATCTGCCT GGAGGAAGGA 101 GCATCTTTrAT CTYITGTACTG TGAACCACAC AGTCTAGCAG CAGCACAGCC AAGGCACTrG GGGTTTCATG AGACTAAGTA CATGCAAT-rC TATTGTAAAG GCTTAAAATA TATACAACTG ACCCTTGAAC AACATGAATT TGAATTGCAT GGTCAGTTAT ACGCAGATTT TCTTCCACCT CTGCCACCCC TGAGACAGTA AGATCAATCA ATCCTCTTCC TCCTACTCCT CAGTCTACTC AAAGATACTT GAAGTCTACT TGAAGATGAC AAGCACAAAG ACATTTATGA TGATCCACTT CT[TCTTCTC TCTAGCUTAA TITAGTTGACT GTTTATGTTA GAGTCAAAAG GTGTATGTGG TCAACTrTAC TGCCAAAGGC CTACAGTATC CCTGCGTCAA GGTAAAATGC CCCACITTCT AATCGTTAAT TGTAATTTTf ATAGATGATG AAACTCCTTT AGTAGTCATA AATGTACTGT GTAGAGGAGT CTTACAAAGC CCACTTFAGTG AATAGTAAAT ATGT-TTCTC TTCCTCCTAA TTTTTTAACA ThTATTGTTA AGAATACAAT

TCTGTAAGGC

ACTTTCAACT

AAGCCTTTAC

ATCTTTTUTT

TTAGTAATAT

ACATAGTTTC

TAAGGGCTAT

GGCTTCCCCC

TTCAGGTCAA

GCAGGGGGGT

ATCCACT1TTF

TTGCAGATCA

TTAAGTTAGA

'TrCAAACAG

CTGAATTIA

AACCATCTGG

CTATAATACA TAIGACATAC GAGTATGCTA TTAGTGGTTA GGGCACCCCT GCCCCCATGT TCCATCCCAT CAGTAAATGG CAAATTGGCC ACTCACCTTG TAATATTTAA GUTATAAAGT AAATAGCATT TTTGTTAGAT ATTCCTTGAA AAGGCAGAAA GCTATATAGA AGCTGCATCC GGYrGCGCTA GTTATGATGG

AAAATATGTC

AGTTTTCGAG

TGTTCAAGGG

AAAAAGATAG

CTCTGTGAGG

TGTTCT-ITGT

AACCTCCCGT

TTGGATAGCT

TTGGACTGCA

CAATT-AAA ACAGAGCAAC TTCTCTCCTG TGTGTACT'IT TACCCAAAGA AAATCCTTAT TATCAACAAT CACAATGCCA TCATAACCAT GGTATAAAAA ATTCAAAATG TCCCAGCTGA AGTGGAGGCA AAGACTCAAG TrCATGGAGT CAGAGYIFTCC TFGCTATTCC TCT'FrTTCAA ATGACCATTT AGTAAGCACC TGAAGAAAAT ACTATOGACO GCATrGAAAA GTGAAGATAG GTT-rAATCTT CTCGAAAATC TAATTCTCCA GATGAAACGC TGACACT7AT CAGATGTGTC ACTGGCCATC ACATTTGACA CAGAGAAGTC ATAACTCAGT GAGTTTCTGA ACCATGGACA GAACGTCGTC TGTGGGACAT GAAAACTGGA TGAGAAATGG GCAGTYITAAA GGCAGAACAT AGCACATATG TGACTGGGTT CGCACTCTTC TTrCATCCTAA ATAATCTGCA ACCAAAGCTT CCAAAAAAGA GAGGAGTAGG GAGGGGAATG GGATGAGAGA GAGTGGAGAT TAATGGTGGC AGTGGTTTCT TCAGGTTCTG GAGCAGGACT TCCTATCTGG

CACTTATACA

AGGGATATAA

YITAAATGATT

GTGTCTCAAG

ACATTTATCT

GGCGCGATCT

CCTCTCTAAT

GGGTTTCTCC

AAAGTGCTGG

TAG'FFCCCAT

TTGTGTCCTG

ATTAAAAGTC

GTATTATGAG

ACCTTACCTA

CCCCAACCTT

GTGGTTrCAG

AGATCCCTCA

ACAGGAGACA

TAACAGGCCA

TGGCTGCTGC

AAATTACTTT

TrTTAATAAT AAATATT-rGT

AAAGCCTTCA

ATAGGGCAGT

TJTAGCTATTA

ACTATACAAA

GAGAGAAAAA

AACGTGAAAA

AAGTCTATAC

TTTTACTTGG

GATTCCCrr

GGTAAATGAA

TAGGAAACT-r

TATTATAAAT

AAATGATACT

TCCCTTTTGC

TTTTTTT-C

CGGCTCACTG

AGCTCGGATT

ATGTTGGTCA

GATTACAGGT

GACTGGGCTT

AGCCCCTAGT

TAATTCTCTT

CCTCTATCCA

GTAGGTAAGT

TTTGGCACCA

GATGAAACTG

CACATGCAGT

AACTGAAATT TGTATACTGT AAAGGCACAA TTCAGAAAAT AGGTGAATAA ATAGTACGAA GATAGGAACC ATGATAAATG CTTAACTCTT CTTGTTTTGC AGATGGAGAA ATTGAAT GTTJACATGAG AAAGCTGCGT ATCTGTTTCC TGCCAGCTAT CTTGGGTAGG TGTGTTCCCT TCTTrTTTTG TTGAGAGAGT CTTTCCCTGT CAACCTCCGC CTCCTGGGTT CAAGTGCTTC ACTGGCATGC ACCACCACGC CCACCTAATT GGGTGGTCTC AAACTCCTGA CCTCAGGTGA GTGAGiCCACC ATGCCTGGCC CCAAATTTAT CCACCCCACA GACCCTATAG CAGCACAGAG ACATTTCCAT ACTTAGAGGA CAGGCACATC TTAGAAGCAA ATTrACAAGA CAATTTAGGA ATGCAGAGGT ;CAGAGCGAGG TTTAGAACT-r ACACCATTTTf TAACAAAAGT TTATTAAAAA TAATAATTTC AATCTTCAAG GAACTCTGCT AACCCAAGTT ATCATAACCC TGGATITTGTA GCCATAATTT TTGGGCTGTT TGATACCCCC TGCCTAGGCT GGAGGGCAAT TCACGATTCT CTTGTCCCAG YJTGTATTF7TT AGTAGACAAG TCTGCCTGCC TTGGCCTCCC CTTTAATGCC CCAAATTATC CCTCTCCCTG GGAAATGAGA GGCCTCCTGG ATGAGACCTC AATCATrGAA ACCAATTAAT TGTCAAGGCC AAT'17GTTCT TGGTACTCTA GGTTAGCAGT ATGAAGGGCT GGGCAGGGGA TCACAAGGAG TGCGCAAGCT CTAACACCGC TGCTGATCTG

CTGCTTTGAT

TAGAGGCTAT

GGAGAATTGA

GTGATTI'GTA

CTGGAATTGT

GGGACCAGTr TrCCACCTCA

TCACAATAGG

CCTrTCTGCA

GTCTCTGCTG

GAGATACCTA

CCTCAATTCC

AGCTGTGGCA

T-rGTGGAAGA

GATCATCAGG

GTGTGCACTC

CTTGCTGGAC

I1TCCTGAATG

TTTGTCTCAA

CCAATCCAGC

TTTTCAGTAA

CAATT11'TCC

CAYITAGATTC

CCATGAGAAT

GAGCTCAGGC AGTAATACTC ATTTGCCTAC

CGGACCAGTA

ATGTCTTCTG

CTITCATAY[A

GTATATAAGT

GATGAAAATA

GATGCTGGTT

TATGAATACT

TGATCACTAC

GTCCAGTAAA

AATGCTGTCA

TFTTTGCATT

TCCCCCAAAT

CTATAAGGGG

CTGGTCCACG

TGTAGCTACA

GAGTTGTGAA

AAGTTTCCTT

GGCATTGGTA

CAAGGTGAGA

TAATGTTAAC

TAAAATGGGG

GCGCAGGCAT

TCTGTATGTG

TGAGTATCAC

AACTATGACT

GAGTTGAGAC

AATGTGATTG

ATATGTAAAG

ATGACATAAA

CGCTCACCTC CTGCCGTGCA CAGGGACCCC TGTTrGCTAGG TATCTGATGA GATATAAATT ATATAATTAT ACATAAACTA TTCATCTTAG CGTAGTAAGA CACTGGGTGA TGAAAGAGTG GGAGCAAATC AATTAACTTC CTCTTCTGCC CTGTATACAG CCTCATAAGG T11'TAAGTAT ATGATGTCCG ATTATTTTAG AGCAAGjGCAG ATCCCAATTC

GCTCAGTTCC

TATAAGCATC

ATTTGATTAT

GGAATATGCT

GGGTGCTAAG

TAAAGATT'T

TTGAAGTCT"T

TAAATGCTAG

TATGCAAGAT

CTACTTCCAA

CCAATGTGGT

AACAACTGGT

CCGCAGGATC

CTCTGTCACA

TATCACATTC AATTGAATCC GTTTTACTGT TCTTATAGAG

TGAATCAACA

CTGGAATTCT

TAAACCTCAA

AAACACTTTC TCCTITCTTT CCTACTATT7 CCITFC1-rAT TCTTTCCT CCTACCAAGA GTAGTACAAG TTCTCTGTAT TACTTATA GTT-rCCTCAT CTCCATGTGA ATI'TAGTTAA ATTCTCAGCA TTCTGATCCT TACTATACAA TATAAAAACA AAACGAAACA AAAACCTCTT CCTA1T~ACA TAAGGCCCCA ACCTAATAT TAGTGATATA TATTAATGTG AACAAGGAAC TAACGAAGAC TGGGAAGAAA TITCACAGACT TGAGAGAAGA AATGGCAGGA TrTCCTGGGA ACAAYITCAT GTAACGTCAA AGGTGGTAAA AGGTCAAATA GAATGAAGAT GGAGAATACC GGATTTTCTr ACAAAATGAT 'I1TCCCAGGAG ATCTCATCAA ATGCACGAGG ATACCYI7CTC AGTI1TCACCT AGTGAGTAAA AGACTGGTAA CATAGCTCAC TTACAATTTG GATAAACAAA ACTAAACAAA CAACATCAAA ATTCAGAAA AAATAATAGC AAAACAGAAA TCAAACACTC AAATTTTGG TCCTTCTGT'T TATTTCATTT TGGATACTCA GTGAATGTTA ATTAACCAGG AAACTTAAAA GTTATTTCAA TTATGAACCT CYITCAATCCT TCATCAATTA TITGAGTAT TCTGGTCTrA AAAACATCTC TrTCTTCTAC AAACT-rCTGA AAGAGATGAA CACCTCCACC TACACCAAAA TAATGTGCTT TGCTGGCCAA AAGTACACGT CCAT=TJAC 102 UTAACAGTCT AAGGAAAGTC TGGTGCAAAT TACTATAATA ATCTGGGTI'G TAAATGGTTF AATGAGATCA TATTTTACAA AAAGTTTTTC ACTACTTAGT ACAAGCTTAC AAAACTCAGA GAAAAAAATC GGCAT-TTATA TAGTTGTGTT ACYI7TTGGTT TCCTGCATCT TT-fCACATCT

CTGAGGTGAG

CCACTCACGA

GGCTCATTTA

CATCAYFFFC TTCATCTTCC AAAGTGGAGT TAGCTACTAC ATTAGGTAAG GTTACTfCAT CAATCACCAT ACTGTTATAA TCTTGAAAGT GAAYITCTTT GGACCCTCCC TTrGAATGCAG TTATACCTAG TAAACCTGAT CCACAACCAA GATCCAAGAC TTTTTTCCCA GCAAATTTCA CTTTGGCCTT TGTGAAATAA GCCAGGAGGT CAAAGGTACA TTCCCAGA'rr T'FfAAGCCTC CCTCATAAAC ACCTGTAATC AGATCAGAGT GAGAAGAAAA GCTTTTrGAA ACTATGTTTT CTCCAGGGAA GTTCTCTTTC AACAAGATGG TTTrCACTAC TGATAACTTA ACATGCTGGA AACCTGGTAA TGTTTCTATG ACTTTATTTT CTAACATCTT CTTTAAATCT TrAGGCATAG CATGCTCTTT GGCAGCTCTC AAGGAGGGCT GTTTTCCATG TGGCTCCAAG TTCCUTGAAC TGCTGGCTGC ACTGAGTGGA CTGTCTGTGT CTTGAGAGGG AGCTGCATTf TCCATTGACT TATGTTCCCA CAAGTGATCC TGAGGCAAGT CAAATTGTTC TGCAGAACAT TTTCTGTCCC TCTCTTCTCC TrTT7GACTT TCTGAGACTG ACAGCTCTTT TGAGGAATCC AGGGTCAAAG CTCCATCTCT AATGGGTGTT AATTCATTrT CCAGATGGTC YI7CTATAGTG AAATTAAACT GAAAGGTCAT CCTCTTATTA AATGCACACA ATCTTrAAAT TCAGATTCTT CAACTTCTGG ATAGAATTrG ATOATACACA CAAATCTGCC TCAATTATTC AATTAGTTTfl GTTGGGCCCA ATTTCTCT AGCAGCTTAT ACATGGTAAC AAATATTTAG AGATATTTCC AAATGACTTT TTAGACGTCT TI'GGTCCTCT TTCCAAGCAG CTCTGGAAAG AAAAAAAAAA AAAAAAGAAA GAAAATGATG ATTAAAGCAA AATGGCACAT TTCACTAAAG TGTAATATTA AACAGCCACC CCCACCCCTC CCTGTCCCAC CATACAGCTG CTrTTC'rrA AAAAGTTGTG GGGAAGAGAG AGAGATAAGA GAYITTGGACA CTCATACACA CCTTAAGGGT TCCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG AAGAACAACA GCAACCACCA CCACTACCAC CTGGACAAAC ATAAAGTCCA AGATATTCAG ACAGGACAGC CTAGCTACTT GCTGTCT-rTC AGCTGTCTfrG ATTTGTGTCC AACCATAYJ7C ACCCCCTAAG CTTCCAGAAT AACT-rCACTT CTGTCTTTTA CAGAAGAGGT GCAGTATTTT ATTTTGGTAA GTCAGCGTCC CTTTAAAAAC ATGCATAGGT ATGGCCTGGT GTGTGTAAAT TCATCCAAGA CUTCACTCCA AACATTTAGT CGAGAACAGC AGCCCTAAGT GTATAGAAGT GGGGGTAATT TGGCAATAAT TAGTAAAGAC TAATTCGGTG GCAGAGCAAA CGCAAACTAG GGCACTGCAG TAGTTTGGAG AGACCTGTAG AAATAAGAAG CAACYITATU GAGAATCTTC TATCTACTGC GCTAGACACT ATACCATCTG CCTCAATTTr CACAGTTCTG GCAAGTGGGA TCTTTGTTCC CT17TATACAA GAYITACAAT TTGGGGGAGA GGCGGGTCAC CCAGTCCCGC GGCTAGGAAC GCGCCTCTTT CCTCTCCCAT CACGCTGCAA GGCTTGGAGT CACTTCCGGC TGCAGGTCCC GGAACAAATC CGACCCCAGA AGTGGGGACT TCTGGCCCTC ACCTCCCCAT TITGAATGTAA TGTTTACAGT GATCCAGACC TGGGGATGCT TGCTTCCCGA CGTGTCCTGG GATCGCGCTT CTGAAAAAGC TCACCTCACA ACGCCTCCTC CGGACCTAAA TCGCGCACCA GTGAGTCGAG TCCTCCAGGG GCTAGAGAAG CCCGACTFJ7C 'ITTCCGGCCT TGAGGGACCC GGGCTCACCA AGAAACCAGC CGCCCTCCTC TCTATGGTTr TGGAGCCGGC GGAGAGCGCG CAAGGGTTGG CGGGACTGCG AGTTTCCGGT CTGGGCTTTG GCGGGTCTGG UTTGAAGCTC TCCTGTTTGA CGAAAGTATG TCTCAGGAAG GTGCGGTCCC AGCTAGCGCG GTTCCCCTGG AAGAATTAAG TAGCTGGCCA GAGGAGCTAT GCCGCCGGGA ACTGCCGTCC GTCCTGCCCC GACTCCTCAT ATCCTTCCTT GGTTGTCACT TCTACCTAGA GAAGGGTGTG GGCGGGTCGC GAACCITTCT CTTCTGTCCC TTCAGACCCA CCGCCAGGCT GGGTTATAYI7 ACCGCGGCCT GAACCCCCTC TFFCYrTGT CAGTGAGTGG GATGAAAAGT GAGOGACTOG AGGGGAAGCG ACAACCGTGG TAGATTTAAG TAAGGCTTrTG GCCCTGGAAA GCCTCGCGGA CGTGTTCTGA CCCAAGGTTT TAGCAGTGGA TGTGGCGTTT TCTTCCATTC CYI7CTTTCAG TTTTTCTGTA CTCGTTGCTT GCAATTAAGT GTAAATACTT TTGCTAGTGG ATAATGGGGG AGGCAAGGAC TGAGACCTGC GGTATGACGA TAGCTCTGGC CTGAGCTTTT GTCTCCCGTA AAAAGGGTGG AGGGCATAGT TCTGTGGTGT TCTCAGACCT CTTTY[CYTC TCTYJTCTGAA AGAGTTCTTC TCGTCCGGGT GCAGCACAY[F CTTTCATGGT AAACCATATG CAAAAGAAAA AAAGTAACCT ATGTAATCAC ATAGAAGTCA AGTTTTGTG TAGGTACAGA ACATTCAAAA ACACTTAAAC ACACGGAACG TGATTCCTCT CCCACCTAGC TTTGCACTTC GTAAATGGTT TCACAAACTG TrCTGATFrcC AAACTATGTC ACCCTI7ATCA CCTCTCACTT AGUTAAGAGG GGAAAAACAI GATCTAAGCC TTGCCCT-rCT CCTACCTCAA GATCTTTrTrG TGGCCCAAAT GTCACTTCCT GTCTTACACT TGTATCACAT TGTTrTGCTTT GTATATT-rC C'CACAGCG TTACCCTCAG ATATTTCATG TTTTrAAAAAT T-rAGCTfCAC TATFFAACA T-rCATGTTT GCATTTTrACG GAAATCT-rTA

TTTCTTJTCTT

CGCTfGTTGT

CTTGATTGGT

TATATGTATC

TCACTTGAGA

T-FCACCTAGG

ACTGCCGTCT

TGCGTGCATA

TCTTCCCCAC

AAACGACATA

AAACCTTGAA

TTGAATCAAT

GGAGTATTAA

TGAATATGAA

AAAGATGTTC

T'TTTT~TGAC

TGGCT'rTCAA

CTCATGCCTT

T-rTTTCACAA

GAATCTCAAT

CATTAGCAAA

TCTTAATAGT

TAAGGGCTTT

AGTAAATAAA

kAGTTCTCAC CTGT-rGGATT

TGTGGTTGTA

CATTTGAGCC

ACTGCACAAA

ATCTCAGAAG

TCAAGGAGTT TCAACTTGAA ATGTGTGTGA GACATGGTGT

AACATAG

TITCAAAAAAG

TCCTCTCTGT

CCGTTTATCT

TAGTTTCCTT

I AGATCTCGTC AT'FrCCC1TT CTCATACCTA GYI7AATTAAC CTCAGCCTGA TTITGTTCTCT TAGAGGGGCT 1TTTCAGAGC TGGCCTGTTC AGTfTCTAA CACYI7CTACA CA'rrATGTTG CACCTAGAAC AGTGCCTGAC ACTTGGGAGT CTAATTAGAC AATGAAAAAT TTGCAATAAA

AGAGACTTCA

CCCAAACTTC

CTCACACACC

CCATCCTCAT

GTTTCTACTC

TTAAACCACT

TACACTCTGT

CAGCC1T1G

CTTCAATCTT

kAAGCACATTr 2 AAAGTTCAT

ACATAGTAAG

AATACTYTM

TCTACAATGC

TTGAGGTAAA OCUAGATACT CTTAGCGTTA TAAGAATTAA AATGATTTrC CTCCTTCCCC TCCTCTCACC CAGGCTGGAG TGAGGCGCTT AGCGCCTTCT AATGTGCCTG GAATCCTAGC CAGCUTTATA CAATTACACT TATTGTGCAG CTAAAGCCCT GTGCCAAAGC CCCC1TTTTT AACAAATAGC CACCCTCAAA TAGGCTTTGG GAGAACAGAG TTAAGTTGAA AGTCAACATT CTCTAGT1T CTTCATCTGA CGATCAGTAA GTTCTATTGT TGCTACCACT CTGATTCCAA ATAAUFCATT ATTCCAAAAA TTACCTTCAA GGTTCCAGGT TCATGAATAC ATTAGGCTCA CATATTTCAT GTTTATGTCT AGGCAGTTrCC CCCAAACGCA ACCATTAAAA GAAATGCTCT AAAGGCAGGA TGU-GATTTr CATTCATTAA AGGGCTAAAA UrCAGCTTAA TGGTAGTATT CATTACCCCC CAAAATCTTT TATTATYTTC CAGGCCTTAC CTGCATGTCT GCATAATCAT AACTGACTAA TMTGGAACA GCTGGTAATT AMIGAGCTT TACTGAAAT11 1TTFCATGAG GCCAATTCTA CCCTACTGAA 103 CTCAAATTrG AGTTAATGAT GACCTCATTr TGATTGCTGC TGTAAAAAAT AAGATTTCGG

AATTCTTGTA

ACCCTGTCAC

TrCCTCAGCC

AGTAGAGATG

CCTCCCAAAG

ATITCTTT7GAT

ATGGTGTATA

AAGTTGGTAA

AAGTACAATA

TGGTGTGCAT

GGCTGCAGTG

TTACTGTGGT

CCAGGCTGGA

TCCCGAGTAG

GTTTCACCAT

TGCTGGGACT

GATTCTTATG

TGAAGAATITT

GATAGGTATG

GAAATGYITGA

AGGACTATGG

GTGCAGTGGT

CTGAGATTAC

GTTGGCCAGG

ACAGGCGTGA

GTGTTGTTAC

ATTGTCGTGT

TAAGTAATAT

GT1TTTT GTTTG1T[GT T-rGTTTTGAG GCGATCTCAG CTCACAGCAG CCAGGTTCAA AGGCACGTGC CACCATGCCC GGCTAATTTT CTGGTCTCGA ACTCCTGACC TCGTGATCCG GCCACCGTGC CCGGCCGGGT TATTCATTTTr AGTAAAACAT TTCTAACAAT TATTCTAACA ATTTGTAAGC TGCTATGTGC AGAAGAATTT GAAAAAAGAT AGAAGGTGAT GAGTGACTTA

AAGAGGAATG

ACGGAGTCTC

GTGATTCTCC

YFrGTATCTTT

CCTGCCTCAG

TCTTATTAAC

ATTATTCTTG

CAGTCAAATA

GGTATAAATT

GGAAAGAAAA ATTTCTTGTA CTCTAATCCC AGCTCCTTGA GAGGCTGGTA AGGTGTGATC ATGTCACCGC ACTCCATCCT ATAGAAATCG GAAGTACAAA CTGGGCATGG TGGGAGGATC ACTTTAGCCC AGGAGCTTGA GGGTGACAGC AAGACCGTCT CTCTTT= T-TTTTTTGA GACGGAGTCT CTCCCAGTr CAAGTGATTC CCCAGCTAAT TATTTTGTAT CTGACCTCTT GTITCGCCCAT CCCGAGCGAG ACCCTCTCTC

GTTTCTCATC

TTCAAAATAT

ATTAAGCCAG

YTITTTTA

TACTCATTGT

TGTACTTTGA

TGAAATGTAA

AATTCCAGCA

ATAAACAAAT

CTGAATAGCT

T-rGTCTAGGT

TACYJTGATGA

GC'TTTCTAT

ACCTAATTT

ATCTTTGCTC

GGATTACAGG

TGGCCAGGCT

TACAGGCGTG

ATTGCCCAGG

CTCCTGCCTC

TG'FTrGTTTT

TCACTGCAGC

GGTGCGTGCT

ATG'I1TTCCCA

ATTACAGGCG

AAGTGATTCA

CTGAAATGGT

ATTCTTCGTA

TGAACATT'rr TAYI17AACTG CTACTYrAATA T-rGCATT'rAA

TTTACAGAAA

TGTCAAAAAT

TTCTTTAATG

TAATTTGAGT

GG'rrTGTTCT

CTCAACATTC

TGTTAAGGTC

CTGTTCTCTA

CTTAAAAGTT

TGTAAATATT

ATCAGCCTCT

GATAACAAAT

GATTCATTCT

TTAGAGTTCA

CGCCTATGCT

TCCTGCCTCA

ITTAAGTAGA

CTAGGTCTCC

TAAAAAAAAA

ATTTCATGAC

TGTTTTCACA

CCAATTCCAA

GAGTAATGAA

TGACAGTTGG

CGAGTCCCCA

TGTTACAGCC

YTAAATTACA

AAACGTTAGT

AACATGTTTA

YJ7ACCATTTG

TCTAGTCAGA

CTTrGGTTGTG

GGAGTGCAAT

GCCTCCTGAG

GACGGGTTCT

CAAAGTGCTG

TAAATAAATA

TATGCATAGT

ATACTGTTTA

TCTCTfATGA TACCCTA11'A

ATTGAGCATA

CATACCTCGG

Yfl7ATAACCT

TTTTGGATAA

TGTTACGA1T

GTGTCATTTA

GAGGAAGTTG

AGAGAGTTTA

GAATATTCAT

GGCGCGATCT TGGCTCACTG CAGCTGGGAT TACAGGTGTG CACCATACTO GCCAGGCTGG GGAYFACAGG TGTGAGCCAC AATCATAAAC CTGTGGATTA TTGAAAAGGC AAGTTTGTCC CCTAATAAAT CI1TAAGTTTT GTCATTGCTT AAATI7TCAAA CTATGATACT AGTATC17CC TTCGTAAGTA AAATTGTT TAGATGTGTTr CTTACAGT TCAGTTACT-r GAAATGAACA ATACCAAAGT GTTTTGTTGA AGACCTATAT AAAACATGAT GAAAATGCTr TCTAAATTGC

CAACCTCTGC

CGCCACCATG

TCTTCAACTC

CCCACTTFGGC

TTGTAGCATT

CTGGGCAATT

TAAAAGCAAA

AGGGTTUTAT

TTAATTATCC

AACTGTATGA

TGTATTCCCT

AATTCATTCA

TGATGTATGT

ATGCAGTCTA

CAAAAGCTGA

ACTTTCTCAT TTTCATGTCT TCATCAGTCT GACTGCTCAG T7TACTCATA TTTTGAGTTA TTTTTCCTTT GTTTTTGTTG GAGTCTCGTI' ACTGCAACCT CCACCTrCCA GGTTCAGGTG CATGCTTCAC CACGCCTGGC TAAT[TTGT GGTCTCAAAA CTCCTGAGCT CAAGTGATCC AGCCGCTGAG CCTGGCCCCA GAGTTTGTrT CTGGAGAGCA GTAGTGCGAT CATAGCTCAC CATCTTCTAA AGTGCTGTGA TTACAGGTCT GGGGGACAGG GTCTTGCTTT GTCACCAAAA CTCCATCTCC CACGCTCAAG CAATCCTCTC ACCATGCGTG GCTAATTTrC TATTTATATA GGTGGTCTI'T AACTCCTGGG CTCAGACAGT TGAGCCACCA TGCGTGGCAT AATTT=T TGTTCATTGT GGAAAATATG AAACATATAG TAAGA'TFT-G ATGAGAACAG TCTCATCTCA CATGTTTATC TACATI7AAAA TTGGTGTTAT TCATGTTTTA AAATGTCATTr TTAATGATGG

TTATAATG

TTGTCACCCA

ATTCTCCTGC

ATTMTAGTA

TCCTGCCTTG

TGTITTGTTT

AATCTACGTT GTGTAATGGG GGTrGGAGTG CAGTGGCGTG CTCAGTCTCC CAAGTAGCTG GAGATGGGGT TTCACCATGT GCCTCCATAA GTGCTGGGAT TCAAGACAAG ATCTCACTCT TGCAGCCTGA ACTCCTGGGT TCAAGCTATT GAGCCATGAT GCTITGGCCTG TGTT-rTTGTT

CTGGAGTGTA

ACCTCAGCCT

TTTATTTT

CCTCCCGCCT

AAGTAAATTA

AAAAACAGAA

TITTCCGTATA

ATTT-rGGAAA

CAGATCCTAT

GTGGTGCGAA

TCCAAGTAGC

GGTAGACATG

CAGCCACCCA

=TITfTATC AAGA317ACAA

TTCCTGCCAG

CTTYTTTGT-T

TCAATAGATG

TTTTTTTTT

GCTTAGATT

TTATAAAATT

CATAGCTAGC

TGAGACCGCA

AGGTCTTGTC

AAGTGTTGGG

TTGAGTATAG

AACATCTAAT

CCTATCCATC

AACTACATTG

TACACACACC

TTTrrGGCTA

GGTAGTATTC

TGTTATFfTGC GTCCACAATT GYJTGGATATG TAGGTCGTTT CCT"TFCTCTC GTTFCTCTGT ATAGAATGTG TAAAGGGCAG TGGCCTTrGT TTTTGAAAAT TATTGTAGAA GTATTTTGAA AGTGTATCAA TGACTGACAT GACAATATTT CTTTC1TT17C ACAAGTGTTA CCAAAGGTAT CTCAGTCTTA GATGA'FrTAT AATAAGGAGT AAGTAGATCT TI7ACAGGCTG GGCACGGTGG TGAGGTCAGG AGT-rCGAGAC TTAGCTGGAC ATGGTGGCAG GCCTGGGAGG CGGAGGTTGC GCTCCGTCTC AAAAAAAAAA TGAATTTAAA TTAT~rGTAG GACAGAGTGA AACCCYITAAT TAACTAAGAG AAAACAUTAA CTGAAAAGCA CAAGCATACC ACATTATTTG TAATTAATCT T[CTTGTACT CATAGTCACT AAAAAGATTC AACTGTTACA TCTTJTAGCTA CATTGTAYJ7G AGATCCAAGT A117AAGATCT

TATTAATTAT

CATGTGAGAC

CTCATGCCTG

CACCCATGGT

GTGCCTGTAA

ATTGAGTCAA

ATGTTTTTAC

AATACTATTA

GGCTCTCT1T

TATAATGGTG

TAATCCCAGC

CAACATGATG

TCCCAGCTAC

GATCGTGCCA

CTCATATGAA

CCTGAAAATA

TTCTAATATA

TTAGTGTGAT

TCTCTGAGAG

AAACCTCGTC

TTGGGAGACT

11TGCACTCCA CCACCTGACA TTGGAACAGA CATGTTrATAA GGAATCTAGC TCAAATATAT TCAAAATAAA CATTAGGCAG TTAAAAACTG GCTGAGGTGG GCAGATCATC TCTACTAAAA GTACAAAAAA GAGACAGGAG AATTGCTTGA GCCTGGGCAA TAAGAGCGAT AAAAAAAAAA AAGAACTTAT ATTTTCAGAT TGTGTGGT7C CITTACTAAC TCAATrAA ATGCTCTTGT ATTrTAAAGC TCAAAAAAAA AAAAAAAAAA AAGAAAAGCT AUTCACAGAA TACATTATTA CATTTAGAT Tr-I=GTTT TAAATGGAGG GAACTAAAGA CTTATTGAAA TGGGTTTCTA ACITTAGCTT TGATGATTCT CTATCTGAAA TAITfCTAG TAGATGAAAA TGGATGTTGA GTGYI7AACAG CACTGTACTC CAGCCTGGGT GGAATATTGG CAAAATCAAG ATATATGGTA TATGTTTTCT TACTGGTG CCAAAATGAA TGAATCGTAA TC1TTCAAAT AAT[-GTTCT TGACCACCAG GCCTATGGGA AACAGTATTT TTGACTGTGT TGCTATTCTT ATAATGTTTA GGTCAT-rTAA ATTGTTAGAA AGGGTGGCTA AC1TTTFCACA GACAAAAAGC T-FGTGTAA GGTCAMrAC 104 TATACCCTTA ATFTCAGGAAG GTTAGCTTGA ATfGGGTCAA AAGGAAACTG GTTAGAAAAT AAGTGAGTAG

TGAATAGGCG

TCAAGACAGT

GTGATTT

GGGGCTTTTG

TTAAGCTAGA

AGTTTTGTCT

GAAATTATTC

ATCCAGACCA

TAAAGAATGT

ATTAAATTTA

GAAGTCATCA

AAGTTTGTGT

TGTGAAAAGA

TTTTCAGTGC

AGGAGCTCTC

AGTCTCCCCT

TTATACTrG

ATTJTTAGTCT

AAAAAGTGGT

TATAAAGAAA

GCATTGACCA

TTATTTAGTC

CAGACAGTTT

ATAGGATGCT

GGAAGTCAGA

AAACAATGAA

CTTGAGCTrT

GGTGTTTAC

TAATGGAACT

AATAGGTGAG

TCTAATGATT

TAATCTTGAA

GTAATT-rCTC

ACTTTCACAT

TACGTGCATA

GTGATGCACT

CAGGCTGGAG

CCTCAGCCTC

ATTCAGTGCA

CAAATTTATT

AAAAAAATTG

GGGGGATTAT

TGATAGCCTG

TGTCTTTTCT

GATGACATGA

CTCTAAGGAA

CAAAATTTTT

TAGAATTAAA

AATTCCTTCC AGAAAATACC GTGCGAAAGT AATACTTA ATGCTATTAA ATAGATTCAA GTTGTAAAAA TACCT'TrCT

CTTGTAAATG

T1TTGCAT

ACCATAGAAA

CTGTATTTTG

ACTGTATGAA TGTGGA117CT CTCTAAAACA TGAACTTTGA TGGAAAATAA AT17CTGTTT TGCTTAATTA GGTACAATTG

TGGATGTTAC

AGTGATTTCT

TGTATGAATT

TATTTTACAA

ATACTGATAC

GACGTGAATA

TAGTGjCAAAA TCAAAUTATC GTATTGTGTT TTCTCTGTAA

CT-FATTCCTG

AACCAGTCAA

GTAAGTCAAA

TGATTAGCTA

TAGAAACATG

ATTT7CAAGG

CAGTTGTI'CC

CAT-FGCTGTA

GAAATTTCCT

CTGTGCCACA

AGCTAGCTGA CCCTACCTGT TAGTATTCTA AATGGCTAGA GGAAGAGACT GTGTITGTT ACAAAAAATA TATTCTAAGT ACAGGATGTG TTCAGCATAT TTTATTACTT GATTJTGTTU- TACAGACTGT GCCAGAGGAC TGTCAAGCCA AAATT-FGGAA TGTATTAGAA AGCAGGAGAG AGAGGGAGCT TGTATTCTTA TGTAATGGCC TAATGTrrGGA AA11TCTGAAT AATAAACTCT TATAAGAAGA ATATGTGTGG AACACCTGCC ATGTGTTTTG AGTATTTGTA GTTCTGATAG ACTAAAGTTC TTTGTAGCAC CCAGCATGCT GACTAATACC TCCTTATTCA CAGACAATGG TGCAGCTCTT CAGGAATCCA TCATTTTGGA AAATATf GAG TTGTGCATTG TAAGGTGAGT AAAGGTCTAA CCTCAGTCCT

AATGGTATAT

ATATTATTGA

TTFAAGGAAG

GAAGTTTTAA

ATATTCAATT

CATCTCTACA

TAATATTGCT

AAAAATGTCA

AATAATA1TT

TGAATATGTG

GATTTGTTTT

ACCTAGTTTC

GCTGGACATG

TGAAGAAAAC

CATGTTATTT

ATTTGGAA1T

CACAATGATT

TTTTTAACC

TGTGTATGTA

TTATACTAGT

TGCAGTGGCA

ATGAGTAGCT

rCATATAATT AAAAGCACAT AATCAATGTG CATAGGGGCT AATAAACTUT TCCATAGAAT TCATTAAAAG TGGCTTTTTG

GAATTTGTGT

ACCATTATGA

rGCCAGAGGT ATfGTTGGG

CGCACCTGGC

TATACATGCT

ATTCAGTAAA

TrTCTCTCATT AGACC'I1CTC

GTTTGCATGG

1TfCTGCTTA

TCTTACTAAT

TGTAAAATTT

AACT-FATATA

ATAACTGATA

AATATGTCTA

117ATTTTTAT

CAATCTCGGC

GGGATTATAG

TI7GGCCAGGC

TACAGGCATG

TGAGACAGAC

TTAGATGTCA

AGCCTTGAGG

CGAATGAAAA

CTAATGTTAC

TGCATCTCT[

TTTATGATCT

TTTA1TTTATC

CAGGCTCMT

ACCC'FITAGT

GTATATGGTG

TATGCATTAA

ATTTTGGGTA

ACTTTATAAT

TTGAGATGCA

TTCTCATATA

TTTATTITAT

TCACTGCAAC

GCGTCCGCCA

TGGTCTTGAA

AGCCACCGTG

GAGTAAAATA ATGTTTGTAT AAGATTTTAC AAAGAACATG TAAGTAAATA ATTGITGCAA GGGTT1TITA GTTFTTATCTT ATTTCCCCTC ACAGGGATCC TGAAATAGTT ATGTCATGTT GAACTTCCTT TTATAAAGGA AAGTTAATCC CACAAAAGCT TGCCTAGAAT TTATGGGTCA TCACTAGTTA ATTAATACCT CTCTTTGCTG CCT-rT-rAG TTCTGTATT[ GCAAGATCAT GAAGCACACT ATATTTAATG GATGTTCACT CTAATAGTAT GAATTAAAGT AAATYI7GGCT 2 GTAATCAGA ATAGTGAATC TGTGTATrCT TCAAGGAGGC CTATTCTCTT CAAAAGCAGT AGATGACAAT GATGATATfT TGAATATGGT ACTATAAATC ATGTATCAAT TAAAATTGTC AATTGATTTA AATCTTACCA AATAAAfTT CCYIAACCTA GATT7GCGTA TAGTI7ACT CTCTGAGGT7r GTCCATATTC AGAGACAATA GTTTATATTT CCTTCCAGAA TACATATAAA CATATTATAA TGAAATAACT CATTTTACAT TTTTTTGAGA CAGAGTCTCA CTGTGTAGCC CTCGCCTCCC GGACTCAAGC GATrCTCCTG AGAGACAGGG TTTCACCGTG GCCTCCCAAA GTGCTGGGAT TITGCTGGTCG TAACACACTT ATATAAAGGC AAAG'TTTGCA GCACCTGTTG CTCTGCAACA AGTCTGCAGT TTAGGGTGGG GTGACTTCAG TGACTTCATT CATCCAGCAG GTTCACCCTA TGTGAGCAGG TCGCTGTGTG GCCACAGCAG GTCATAGCGT GTGGCCATT-r TTATAAATAA TGAATTCT[C CT-MAGAT TAGAATATT7 CAGTTATAAT TGGTAGGTAT AAACTTCAGA AGTTTAAATA ATTCTITTTGA AATJTGTTCAG TAGATAGT117 TG'FrATCTTT CTT-rGCAGTT ATTJTCATGCC AATACTTGGA TTrCCATAT TCCCCAATCT AATG117CACT GACACTGCTG TTTACCCTGT GGCCTCTAAA CATGGGCCAG ACTAGAACTr T-rCTAGGATT AGATAAATTG TGTrCACACT TAATTCCATT GGGATAGTGC CTGTAGCATT TAAGAATATC TACT-rTATAC TCTTGTACTA CCAGGACATT GCTTrAAATCC ATTCTTrGAAA CCACACCTGG CTAAT'FrTTG CTCCTGACCT CAGGTAATCC CCCAGCCAAT ACTAGTYITAT ~ATGGATTAT GAACAAGAGT CATTGATTTT ATCACTCATT Y TrCAAAACTT

CACCACCTCA

ATGTCCTGAG

CACATCTGGC

TCTCAGATAC

CTAGCACTTT

TTAGCCCAGA

TCTACCACAG

TT7T1TTCCT

AGGGTACAAC

AGTTAATATT

CACAACTGTTF

TAATTATAGG

ATJ7CATTCTT

AGTTTATAAT

TAATrATTCA

TCTGATAATC

ATTAAAAAAA

AACCACTMT

ATAACTATAA

TGTACAGTAA

CATCAGATTC

ACATACATAA

AAGTITGCCAT

TCATTTACTC

TGGTATAAAG

AAATCTATTT

ACAACT17CT

TGTTGGCAGA

CTGATGCCAG

TCAAGTTTCT

GTCATTGTAG

ACTGAGTAAA

TAGCAATTTG

TTITATTCCA

CAATA1TAT

TCCAAGTTGT

AGAAACTCAC

TATTGGATAT

TAAGTAAGTT

TGATTCM~A

CAGATATTCT

ATGTTCYI'CC

CTTCTGCTAC

TTAAAACTGA

T17AACTTT

TTAGGGGTGA

AACATTAAAG

TCAGTGGTrA

CTTCTGAGCC

AGAGTAAGT1'

ATTCACTATT

CTGATCCACC

GGCAGAAGTA

TGGTTTCAGG

GCTTGCCT-rA

AAAAGTGTGG

AGCCTFGCAT

TTTTGTCATT

CTGAACATCT

AAAAACCATT

GTTACGTATT

CCCCATGACA

CTGCTCTGTT

TGT-fTGTTAT

GATTGCATTT

ACATGTAGCT

TAGTrAGCTA TGTTG1TTAA

ATATAATCTT

CTGAAACTGA

GAGGAGATGT

GTCAGTGTAT

AGAGTGTTGC

CTT'GGGCTAT

GGTTTTGTGC

TATTTATTCA

TGGGGCACTA

CTTGAGAAAG

GTTJTCTAAGA

ATTTfAT1TAT

ATTCACAAAG

GAATACCATG

TTGGATTAGA

TTAGTTTAT

AACAAGTGTG

TTAATTCAAT

1TfGGATGTC

ATTTCCAGTA

'rrrTACTTT AAAACA1TI

CTCAAGCCAA

GTACTTCAGA

CCAGCTATCA

TTCATTAGGT

AGCAT1TfAA

GGTTGAGATG

TTTrCAGGTCT

CTGGGAGCTG

'ITGGTTAATT

TATTTTTAGT

ACCTGCCTCA

TTTTAAAGAA

TTGAAAAACA

AGTGTATCAG

TGATTCTGTG

GCTCACCCAT

CCATGTGCAT

GTAGCAAAAG

TGTCCCCCGG

GGCAGTCATT

GATATTAATT

ATI'ATATCTG

YITAGGTCATC

ACACTrAAAT

CAAATGTTGA

TTFAAAAGTTC

TGGACCATGC

TTAGAAAATG

GTGTGAAT

ATTGGACTTC

AATAATGGGC

AGTATCCTAT

ACYTTAAGT

AGGGTCACCA

TAAAAATGGT

TAGGTACTTr

TATCACATGT

TCTCTGAACG

105 TrAGTTTGCT CATCTGAAAA

CATCACTGTG

CATCATCACT

AAAAGTAAAT

CCTCTGTGGA

ACCAAACTCT

TGTGTACCTT

TTCTrTGATA

CTCTCTATTG

TrTAACATTC ACCCCTT7TT

GAAAAAATTA

TATGTGATAT

AGTTACTTGA

CCAGTCCATA

TCCTfrCCATT

TAGCATTTTA

TATFTAAGAG

AATTACTTfl CCCTCTYrTGc ACAAAAAflC

CCAACGCATT

TTGATATAGT

ATTATATTCT

TAGTACCTTT

AGTACTCAGG

CCAAGCTGGA

TGCCTFAGCC

ACGGGGTTTC

CCCAAAGTGC

GAATTGAATA

GGAATTCCT'r

GTCCTAAAAC

TTTAAAAAGA

rrc'rrocrrc

TTGTCCTCAC

ATCCTATATC

AACCTCCTCC

AAATGCTTAG

GATTATCTTC

CAGATCATGT

TGCTGCCTCC

CCTGTCCCAG

GCTAACTCCT

TCCTITACCCT

TAGCACCT[A

TCTCTCATGC

CTCCAGGGCC

GCAACTTA1T

ATGATGCTTT

TGTGTTACTT

ATAAAAAGCC

TGGAAATAAT

AAATGTGCAT

CACTCTTACC

TACTCTATTG

TITCACCAGCC

AGTCYI7TTCG

GCTTACTGTC

AAGATTAAGT

GACTCTGTCA

TAGACCACAA

TGGTAGAATG

TAAACAAATA

TTGATTGTTT

GTGGTGATTG

AGTTGAAACA

AATAGCAACT

GACACATAGT

CTCTTCCAGT

CTTGAAGTCT

TGTCTCATGC

TGGTTTTTCC

TTTCAGTTCT

TAGATTGATA

TTTGACAAAT

G1TCATGCA

CCTCATACAT

TAACTGCTTC

TTTTAAATGT

TATTCTTTTC

TCYJTGACAGG

TAATACTCAA

TCATT[TCTG

ATCCCATTTG

TGCTCTCCCT

ATCTGCCTAG

CAGCTTAAGA

TCCYI'ACCCT

CACAGCCCTA

GGTAAGGCGG

AGTAAGAATT

GTTATAGTGA

GGAATTAGCC

CCCAGGAGAA

ATTAAGAATA

ACTCTTAGTT

GATGCTITCTC

GTTATATCTT

AAGAATAAGT

ATITAATTATT

AGA'ITrGTGTC

CAATTAATAT

GAATTGAGTT

ACATCACTAT

TGATCTTTTA

ACAACCTAAT

CCTCAAACAT

TCTCCTATTT

CATGATAACA

TAGATTAGGT

CTrAAAATTA

CATTTGTTTG

TTTACACAGA

AGAGGTAAAC TGGGCACATC TTAGTTATAT

TCTACAAGGT

TTrTTATTCA CAAAGATATA ATTACTAGCT CTTGiTTACA GTUAGCTGAG CAGATOACAC AGTCAGATGC

AACAGCAACT

GAT1TrAATTr

CACCCAGAGC

TTGGTAACTG

T-rTTGT-FCAT

GCGACCTTTA

CATACATTTG

AAAAATTTGT

TGCTTTCAGA

ACCTAACAGI

GTGCAGTGGT

TCCTGAGTAG

GCCATGTTGG

TGGGATTACA

TTrTCTTCCTT

TGTACCTGCG

TGGTAGCAAC

AGTTCTGAAG

TCT-rCT-rTAT TTCAT-rCGTG C'FFATTTTCT TTGGCAGTTA TATTTCAYTT GGGTG1T7T ATI'GTATTAG AYITCCTAACT G'rFGGTCACA GCATTCTTCT AYITTGTATAA GATCTGATAT GGGATACAAG TATGTTTGTG TTTTTATTTT GAAAAGTTAG

AGTACGATFA

CTAGCCCTCA

TATATGTCAT

ATGACCTTGG

CTGGGATTAT

CCAGGCTGGT

GGTGTGAGCC

GAATAGCAAT

CTCTTCCCTG

TCCTAGGGCA

GTAGTAAGAA

CTCACCTGCC

CATCCT-rTCT

TTGGGAATTA

ATIFAT"T[A

TTGThTTTTT

CTCACTGCAG

AGGCGCCTGC

CTCGAACTCC

ACCGCGCCCA

GACATAGCCC

GTAAATCTCA

TTTTGATCTG

GCTGTCATTG

CAGAATCCTT

AGCTGCAATC

CATGTATATG

AGTGTTGAAT

TAACTCATTT

ACTATAGTAG

1TFTTTFFGAG

CCTCTGCCTC

CACCACGCCT

TGACCTCAGG

GCCTATATGT

CTrCTATrGT CCAGTCAGCT ATGGGGGTGA GGGCTGATCT GGAAGGACAG GGAAATGAGG AGTAGTGTTA CCTCCCCTTG TATCCCTTCT GATTCCTCTT ACCTTGCTAA AATGGCAGGA AGGTTGTITT CTI7CTTTACC TJ7TATCCTAT TTTCAGTT TCCYTCTTGC TTCTCTTGAC ACCACAGAGT GGAAAATTAA ACAGAGATAC TTGGACCAAG TGGCAAGAGA GAGTATGGGG GCTGCTTAGC ACTGCTTATA GATGGAAATC AGAAAAT1TA TTTGGGACTG ATAAATGTGA CCAGTTCTGC TATAAT-rTCT TCAATCTTAA CTCCAAATTC TTACCAATCA AAGTAAAGTA 'ITGAAGTTTT CTATAACAAA ATCCCTrAAA CTGGGTAAGG GCTGGGAAGC CCAATATCAA GGCACCAGTA TGGCCCCTTG TFGCTGCATC CTCACTTAGT GCACTTATGT CATTCATGAG GGCAGAGCCC AGTATCACAT TGGGTGTTAG GTGTCTGGGA AGTCAAAATA AAACCAGTAG A'T[TAATTAA GTAYFAATTT CCTGGGGTTG CCGTAACAAG CTCTCACATT TCTAGAGGCA GAAGTTCACA AGAATATATT TCATATCT-rT CTC'rFAGC'rr GTGTCTTCAC ATCATC'rrTr TATAAGAACA CCTCATCTTA ACTAATTATG TCTTCAATAA TTAGAACTTA AAGCTTTT-rG GGAGGGACAC CAATTAAGTC TTGAAATTGG ITTCAAAAAG ATAGTTCTT AGCCCCCAAT TTITTTFTT TCTGTCGCCC AGGCCGGACT GCGGACTGCA UTCACOCCAT TCCCCTGCCT CAGCCTCCCG ATTTTTTGT ATTITTAGTA GAGACGGGGT ATGATCCACC CGCCTCGGCC TCCCAAAGTG CAATTATTUA GTrTTFCTAT AAACAGGGAA CTAATTCCTA CTUATGTITA TATAATGCUT GTATCTGTTG CCTACACTTA GATTTTATFG AGTAAGATGA AGAAAGTCTA CAGGGTGGCT GTACATAAAG AATTCTCTTA ACTGTCCAAG TTACTGTCCA TTGCCTGAAA TGATCAGCGA CGCCCTCTGC CCTGGCAGTT TTCACTTTGT GATTATAAAT ATrAGAAAYF GATTTGGTGT CTAACGAGGG r3CAAGGGGCA AGACAGCTCC TCATGACTTA ATCACYJTCCC GGACACCAAT CTTCAAGCCA TATTACACTA TJTTATAGAAG TTACCACAAA CTAGGTGGCT GTGTGTCAAT AGGGCCATGT CTCGGTGTCA CTGGCAATCC CCAGTGATAG TGATTAAGGG CCCTAYITCC AAATAAGGCC AGTTCAACCC ATAACAACCC AGAATATTCT ATTAGAGTTU TITIlTTTTT TTTrT= GTGGCGCAAT CTCGGCTCAC ALGTAGCTGGG ACTACAGGCG TTCACCTTGT TAGCCAGGAT CTGGGATTAC AGGCGTGAGC AT7TATFGT GTGGCCCTTA TTAGAAATTT GTATTAT[CA CCTGCTATAT TTFAAATTTTA AGATATJ7GTT AGAGGTCCTA TTTAGGCAGA GCCTTFAAGCA TGTGTGAAGA CATTCTTTTC ACAGGTAAAA TTGGGCTAA TTTGAATGTC TGGGTCAGTC TGGGATTATT TATATCCCAT CCTCTGGGGT CTGCCTGGCT TCATTCTTTT CTGCATGAGA AATC'rGCAT TTTT7CTTCA TATGTATCAG TCTTTTAAAT TGGTATCCCA 1TFATGAAAC TCCTGTAACA CTGTTFATACA TCCTAAATA TAAGATTAAT ATGGCGTCTC ACTCTGTCAC ACGGGTTCAA GGGATCGTTC GGCTAATTTT TTTAGTAGAG TGGTCCACCC GCC1TGGCCT AATAATTYI7A ATGGGACCAT ACATCTGCAA OCTGATACAG AAGTGTAGGG GTTCATCCAA ACCCTAGGGG AGGGTGGAAC GGAAGGGGCT AAC1TTTT7C TCCYTFFCC CTTFTCCY-FTT AAGGAGAAGT TTG'TTFGGGT AGATTCATAT TCTCAACACC TTGCAGCTAG TACTTGGAGA AACAACAGTA TAGTCTATAG TATATCTTCA GTTTATATAA AAAATTCTCA TTTCAAA TGGAGCTTTG AGGTGGACTG TGTTCACTAT TAATATTAT GTTTAGTCC ATTTAGGCTG TATCTCTCAC AGTTCTGGAA TGTGCCGTCT GCTTCAAAAA CTTCAACCTC TUATAAGG CAAAGGCCCC ACCTCTTAAT TATCATCTCA CTTFGGAAAAA CATGTGATGT ATCATTCCTT TAAAACAATA GAA1T[ATT TCTCTGGAAG GCTTTAGGGG UTAGCTTACT TTrGGC1TFCT CATACCTTAC TT-FAATATGA ACATTCTGAA GTATTGGGAG CTAAAATCGA TATTUATTCT ITAATGTATA GTTTTAACAT ITTTGAGAC GGAGTCTCGC TGCAAGCTCC GCT"CCCGGG CCTGCCACCG CGCCCGGCTA GGTCTCGATC TCCTGACCTC CACCGCGCCC GGCCTGCCCC GAACTAATU- AATTTCCACT GAAAATAAAC ATATACTATT TrAGTA1TI AATTGTTA TUAAAGAAAG AATGTGCCTG TAATCTCAGC ACTITIGAGA GGCCAAGGCA GAAGGATTGC UTGAGCCCAG GAGTTUGAGA CCAGACTGAG CAACACAGGG AGACCCCCAT CTCTACAAAA AATAAAAAAA TTCTCCAGGC 106

CTCATGGCAC

TrGAGGCTGC

ATAGATAGAT

TAAATAGATA

TCTAAATAGA

AGATTAGATA

AAAGAAAGAA

CACACCTTCT

TTAAGTTATT

TGCTATTTAG

GAAAATTTAA

GAGTACTTAT

TAAGTAGGTA

AGATAGGTAC

AGGTCAGTGT

TAATCGAAAA

YUGCTTGAGC

AATTAGCCAG

GAACCCAGGA

ATACCTGTAG TTCTAGTTAC TTGGGAGACT GGGGTGGGAG GATGCATTGA GCCCAGGAGA AGTGAGCCAT GATCAGGCCA CTGTACTCCA GC-FrGGACAA CAGAGTGAGA GCTTFGTCTAG AGATAGATAA TCTAAATAGA TAATAGACAG ATrATCTAAA TAGATAATAG ACAGATTATC ATAGACAGAT TATCTAAATA GATAATAGAC AGATTATCTA AATAGATAAT AGACAGATTA TAATAGACAG ATTATCTATC TAAATAGATA ATAGAYFATC TAAATAGATA ATAGATAGAT GATAGATAGA TAGATAGAGC TTGGACAACA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AGAAAGAATG GTGCTCATAT TTTAAAGCAT TGAAAAATGG TCTfCCTTGC UTATATTACC TTGTTGGCAT TAAGATGCAA ACTTTGTTTf AAACAGTTGA GTAAATCAAA GATGGGACTG TGTGTTAMT ACCTGCT1TI TGAAAATGTA AAAATAAAAC

TAATGAAGTA

AGTAAGCAAA

TCTGTGCCAG

ATTATTATAG

CCAGTGATGA

AGAATAAACT

GGCTGAGTGT

AAGCTAGAGG CTTCGAACAA ATCTTGTGTA CAAATAAGTT GTGTGTCACC ACTCATTCAG

GAAATGTTGT

AATGGTATGA

AGTCAGGAAA

TTGTGCTTTT

GGTGACCCAT

TAGGAGTTCG AGACCAGGCT GAGTGATGGT GCGCACCTGT GGTGGAGGTT GAAGTAAGCC GACTCCATCT CAAAAAAAAA AAAAATGATC

AAAATGGACT

AT1-rAT1-AA

CCTCCAACAT

GCTCGCTGGG

CGACTAGAGA

TGGCCAAGGA

ATCTCCAACT

TGTITTCCCT

TATATATATA

CATGAATATC

ATCCCCTGTC

CAAAGATGAT

ATTTTCAAAT ATTTTTAATA CTTGTGGAAC AAAAATAAAC GAAGGTCTCC GCAGCACTTC CCAGCTTCTG TCCCAACCAC GCTACAGGAG AATCACCAGT TATCTGTGCC GACCCCAAGA CCAAAGCCAT AAATAATCAC TCTrACAATG CATTCTGAGG TT1-TTU AAAAAAAAAC AGITATTTTT AAACTGTAAA ACGTGTGGGC AATGTJTCCCC CAGTATGAAA ATGTCATTGT

AGGTGCCCTC

TCITIGGAGG

GGTTTCTI'AT

AAATTTGCAT

GGCTGTAATC

GGCCAACATG

AATGCCAGCT

GAGGTCATGC

AAAGAAAGGI

AGGGTCAAAA

CAGAAACCAC

TGTGGCTGCT

CTGCTGCTTI'

GGCAAATGTC

AGAAGTGGGT

CATTTTTGAA

TAACCTCATTr GTATTGCA1T

GCTTTGTGCA

CTCTCCTCTC

TCTTGTGAAC

AACAACTTAG

ACTGGGTATT

GGTGATATGA

AGGACTGTAT

GTGAAACCCC

ACTFGGGAGG

CACTGCACTC

GAATT[TCAT

TGAGGGATC

CACCTCTCAC

GCTCATAGCA

AACCTGGCCA

CCCAGAAAGC

GCAGGATTCC

ACCAAACCAG

ATCAGTCCAA

TAATJTTATTG

GATTCTTTAC

TTCCTCCCTG

CCAAAGTGTG

TCTGTGGCTG

ACCTGCTGCT

GTGGCAAATG

GAAGAAGTGG

GTCTCTACTA AAAATACAAA CTGAGGCAGG AGGATCACTr CAGCCTGGGC AACAGAGTGA CTACCCTATT TCTGCTGAGG GCATTTrTTTC AAGTTT[ATG GCCAAAGCTC ACACCTTCAG GCTGCCTTCA GCCCCCAGGG ATAGGAAGAT ACCCCTTCAG TGTGATCTTC AAGACCAAAC TCTAGGT-1TA

ATTTCCTCTT

TCAYJTTAACA

AGTCTAGCCT

GGCTGGCTCA

TGACGTCTAT

TAGAGAGTTC

ATTAGTAGTA

GAATGAGAGA

AGTATTTCCA

GAGACACAAG

TGGGAGTACA

GCTGATTATA

ATCYIX2AAAA CCAGCACTTT GGGAGGCCGA GGTGGGCAGA

ATGAAGTATC

AGCCTGAGTG

AGGGCATGGG

AGGCTTTAAA

CCCCTGGGAG

GAATCTTGTA

ACTCATTAAA

CTGCTCATAG

YrAACCTGGC

TCCCCAGAAA

GTGCAGGATT

TGGACCAAAA

TTGCCTAATT

TM~AT7ATA

ACTTATCCTC

CCCCAATTCG

AAGGTCCTGG

TGGAAGTAAA

CAGCTGCC~r

CAATAGGAAG

GCTGTGATCT

CCATGAAGTA

TGYJ7GTT"TTA GGAATAC ATGAAGGTCT CCGCAGCACT CAGCCCCCAG GGGCTCGCTG GGCCAGCTTC TGTCCCAACC ATACccc'TC AGCGACTAGA GAGCTACAGG AGAATCACCA TCAAGACCAA ACTGGCCAAG GATATCTGTG CCGACCCCAA TCTGGACCAA AAATCTCCAA CTCCAAAGCC ATAA ATCCAGATGG ATTAAAAAAT GTACCAAGTC CCTCCTACTA CTAGGATCTG GAATCTGGTC AGCAATCAGG AATCCC7CA TGGAATCTCC CACACTGTCT GCTCCCTATA AAAGGCAGGC CCAACCCAGA AACCACCACC TCTCACGCCA AAGCTCACAC CACTTCTGTG GCTGCTGCTC ATAGCAGCTG CCTrCAGCCC CAACTCCTTA CAGGAAAGGT AAGGTAACCA CCTCCAGGCT CTGCAAATTC TCCATTTGAA AAATAGGGAA ACAGG1T=G ATCCAGTCAC TGGAAGAGCC AGAACTAGAA AGCTCCCGAG GTGCATCCTT ACCCAGCTAT CCYITACAGTG 1TTGGGAATG TGGGCATTTT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA GGACAGCTTT CAGAGACAGT GGCTAAGAGA AGAACGAGGI GACACTCTTT GGGAAAGTTA TCTAGGAGAT ITGTTCCATA TACTGAGTGT ATCGGTCCCA CTGAGCCAGT GCATAGCATG TAACAGAATU AACTAAATTA ACAAAAGTTA CTTTCTCACT GGCTTCTGCA 'rFTrATACTC AGGATTCTAG ACTGATGGAG ACTGTGATAA AGCAGAAGAA AGCTCTCAGG AGTCTTGCAT CCATCACFIT GTCTCCTrCT TTATITGATCA AAACTAA17A AATGCAAGTC TACcYTGTGT CTCAAAACAG AGGATGGAGA ATGGCCACGT AGGTCTTTAT AATGACAGAG CTAGCATTTG TACAGTAATG ATGAGTCCTC AGTGCACAGG GGAGGATGCT TAAGACYI7CA GAGCAGAGGG ATTCTCCCTC CACCTCTCGC AAAGTCATGC T-rGGAAATGT CTATGTATCA TCATGTGGCT AAAATTCAGC YI7cTGTCCCA ACCACCTGCT GCTITAACCT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG CCTCCCCTAG ACAAAAAAAT AATGTCTAGG GCACAGAGTC 1TGACCTCT ATGGTCCAAT TCA11TAATTT TCACAAGTGA IfTGCTGTAGT CATATCAA1T TCUTCAAGTC AAGAGCAAAG CTAACCCAAG AGTCTCATCC TTrcCTCCTCT CCGTAGCAAC ATTFAGGGTC AAATGGGCAG AATTTfCAAA AACAATCCTT CCACATATTC CCCTCCT~rT CCAAGGCAAG GCTrGCCTCT C117CTGTTCT GCTTGACTTC TCGTGACCCC CGCATGGGCA AAGGCTTCCC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA

CTTCAGCCTC

CCAGGGGCTC

ACTAGGTCAG

TGGGTGGACA

TCITTTCCCC

GGGAATGGCT

TTAGAAGCTC

CCCAGGGGAT

ACTCATT'ITC

GTAACAAACA

TGTACTAAAT

CAACATGAAG

GCTGGGCCAG

CAAGAATCTT

AGAAATGCCT

ACATTCAAGA

CTGTCTTACT

AGTATGTTAA

CTCT[GAGGI

CCATACTCTG

G1TCTAAAT-r

ATCTATAATG

AAGTTGCCAT GTGGGGGAAC AGGCAATGCA CTGTGGCTCA ALTGCCTCCAA CCAAACAAAA ATATITGGTG AAAATTACCA TCACATTGAC CAAGCTTTGT GAAGACACAG GACAGCATCC AAYJ7CC1TGC YfTCTCCTAA CATTrTTTC TCTGTTCATTf GGCCAATAGG AAGATACCCC AAAGCTGTGA TGTAAGTAAA AAGAACTGTG GGAGTCATAG GTGTTCACTC CCAGCTCCCT ATGGTTTTAC TGGGCCTTTA CCYITGTCCA GGGGCAGATG CCAATTGCAT CCTGATTCTC

GTCTCCGCAG

GTAAGCCCCC

TACAGACTCA

CAACCGTCAC

GGGCCGCTGG

GTGGGCATGG

TTCGACTCCA

GACfATTTT

GTGACAAATT

ATCAATGACT

TATGGGCTCA

A117GATGGAT

AAAATGACAC

GTGGCCAAGA

TGACCATCAC

CCATACACTC

TCCAGACACA

CTTCCTYITAC

T1TTTTCCCC

TTCAGCGACT

TAAAGTTCAC

ACTCTGATAG

GCCTGGGAGA

AGAGCAGCAA

GTCCTTAAAT

CCCACAGCTT

CAAGACCAAA CTGGCCAAGG ATATCTGTGC CGACCCCAAG AAGAAGTGGG TGCAGGATTC CATGAAGTAT 107

CTGGACCAAA

GTTGCCTAAT

GTTTTATTAT

TAAAAC'FrAT

GGAGCCCCAA

TGTAAAGGTC

TAAATGGAAG

TTTTfTGTG

CGCGCCGCCC

CAGGGACCCC

ACGGAAGGAC

GAAGTTTGAT

GGT117TGAAG

CATATGGAGC

CAACTTAGAG

TCTGCCACTG

ATCCATTrCTC CTTCGGTfTQC

CAGAACACAG

TCAGACATGA

TCTCTTATAA

GTGCTTGACA

TCAGCGTCCG

AGCGCGGCCA

GGACAGAAAC

GCCCAGATGA

ACCCAGGCAT

ATGGCCTCCT

CATGAGTCCA

GTTCTGTCAC

CTAAACTATA

AATCTCCAAC TCCAAAGCCA TAAATAATCA CCATTTTTGA AACCAAACCA TrrGTTTTCCC TTrCTrACAAT GCATTCTGAG GTAACCTCAT TATCAGTCCA ATATATATAT ATATATTTTT YTF-AAAAAA AAACGTATTG CATTTAATYF CCTCCATGAA TATCAGTTAT TTTAAACTG TAAAGCTTrTG TGCAGATTCT TTCGATCCCC TGTCACGTGT GGGCAATGTT CCCCCTCTCC TCTCYJTCCTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA TTGTTCTTGT GAACCCAAAG TAATGTTGTT TTAGGAATAC ATAAAGTATG TGCATATTM ATTATAGTCA GGAAATCCAC ACTGAGCTGA GGGGG GCCAGGTCGC TGTTGGTCCA

GAGCCTGAGT

AAGGGCATGG

ATTGAGGCTT

'ITACCCCCTG

CCTGGAATCT

TGTGACTCAT

CTAGTTGTAA

CGCCGCCCGT

GCCCGCTCAG CGTCCGCCGC CGCCATGGGA CCAGAGGCGG GGCCTGTGGG

ATTCCCCAAG

TCATCCAGAG

AGGGTGCAGC

CACGGGCCAC

TGAAGGCAGG

GGACGGCTCC

TCTGCCCAAG

AGATTGAAGC

ATCTCTTGTT

AATGTACATG

AAGGGCCAAA

ACAGAAACAA

CCAGATGAGC

CCCGGTGTCA

AAGGAACTCA

TGCTTYITGGG

TTGCTCTGTA

A'TTTCAGGTT

CGCACAATCT

GCGTACCGTA

ACCGCTATGG

CGTGTGTGGT

ACCTTTCAAG

TTGGGGCAGA

TCCCTCCCAA

AGGTGGCTGG

GCTCTTGATC

GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG GCGTGGAGAT CGAGACCATC TCCCCCGGAG GCACTACACA GGAATGCTCC AAAATGGGAA TTCAGAATTG GCAAACAGGA AGTCATCAAA GGGCGAAGCT GACCTGCACC CCTGATGTGG TGCCACCCTC ATCTTrTGACG TGGAGCTGCT AGATGGCTGC TGCTCACCCT CCTAGCCTGC AGTGTGCTAA CCTCACTGCC TCATGGCATC TGTGYI'CGTC AGTGTTCATG CGAATTCTTG CTTGAGGAAA GTGCAT-rTTG TGTGATGCAT GTAGTAGCCT 11TCCTGATGA ACACTGCC117 ACCTTCACTT AAACCACACA CACAAGGTGC CACAGAGGGA CTTGAGCCAG TTACCT-rTGC TGTCACTrTC ATrCTGTTAG CTGCTCACTT AAACAATGTC CTCTTT7GAGA AAATGTAAAA GAATTCGGGC CGCCGCCAGG TCGCTGTTGG TCCACGCCGC CCGTCGCGCC CCGCCGCCAT GGGAGTGCAG GTGGAAACCA TCTCCCCAGG AGACGGGCGC

GACCTGCGTG

AAGCCCTTTA

GTGTGGGTCA

CATCCCACCA

CCCTfAGCTC

TATGGAGCTT

TCAGCTTTGC

TGCCATAAAC

TCAGTCTTTT GGATATAGGT ATTAGAATAG GAATTGGTGT TTTATCTATT ATATATTAAA GTGCACTACA CCGGGATGCT TGAAGATGGA AAGAAATTTG AGTTTATGCT AGGCAAGCAG GAGGTGATCC GAGGCTGGGA GAGAGCCAAA CTGACTATAT CTCCAGATTA TGCCTATGGT CATGCCACTC TCGTCTTCGA TGTGOAGCTT CTAAAACTGG CCTGTTCTTG GATCTGCCAT GGAGGGATCT GGTGCCTCCA TI7CCTGATGT TCCACTCCAC TTTGTATAGA CATCTGCCCT Y[CCGACACC TCTGTTTCCT CTTCCCC1117 CTCCTCGTAT CTCAAGTI7AT TCATTrTATT TTG1TTTCAT TTTGGGGTGA TTCCAATTAA GTACATGGTC AAGTATTAAC AGCACAAGTG TGGGGGGGGG G17TGCAAGA ATATTTTATT TTAATTTTTTr CATTCTTGCT GCTGCGCTGC AAAGCCATAG CAGAYTGAG TTGAGAGATG TCTTTGGGTT AAATTAAAAG CCCTACCTAA CTCCACCAUT CCCACCCACC CTCCCCTTrAA ACCCTCTGCC TGGACACTAC AGGTATCTGT CCCTGGGCCA GCAGGGACCT TTCATCCTGT GGTTTTTCTA ATGGACTT-TC AGGAATTTG TCCTAAATCT TAAGAACTTT AATTGACAGT TTCAATTGAA AAGCCCAGCC ATCATGACAA ATCCTrGAAT GTI7CTCTTAA ATCTCCTGTT TTTErGATGCT TGGCTCCCTC TGCTGATCTC

TAAAGGCTCT

GCCCGCCCGC

ACCTTCCCCA

ATTCCTCCCG

AGAAGGGGTT

GCCACTGGGC

AATGACAGGA

GACATGTGCA

GACTGAATGT

GTGTGTTTAC

AGATTCAGTT

GTAGGTTAAC

GGATGAAATT

GCGCTGTTGA

AACTGAGGTG

TTrTGAAAGTA

CTGAAGCCTT

TAATCTCATA

GGTGCTGTTT

GAAAATGATG

AGTTTCCTGG

ATCGTTGCTG

GGACTGAAY[

GGGATGGGGA

GATCATGTTC

CTrTGTGGCC

ACTTTCCAAG

GTAGACTTAA

CTGGTCATCG

CTTTECCTCC

CACCCYJTCCC

GCCGCCGCCA

AGACCTGCGT

CAAGCCC1TT

AGTGTGGGTC

TCATCCCACC

TCCCT-rAGCT

ATATGGAGCT

CTCAGCTTTG

ATGCCATAAA

CATCCAAGTG

TAGACTGGCA

T-rATTTACAA CATGC1TITT

CTGGGCCTCA

TAGTUCATTr

AAGAGTCTGG

AATAGTAACC

TTCCCAAACT

CTACAGAAGA

CTTTACTGTA

ACAATATTCA

GCCCTAACCA

CAGAAAAGAT

GCACAATCAA

ACTCTCCAAG

GAGCCT-rTGC

ACTGCAATGC

TFr~rTTTTT

CTCCACCACT

CACCCAGTGA

CAGCTTCAGC

CCAGCACCAT

TGGGAGTGCA

GGTGCACTAC

AAGTTTATGC

AGAGAGCCAA

ACATGCCACT

CCCTGTTCT-F

TTTCCTGATG

C'FI7CCGACAC

CCTCAAGTTA

TGGTTATTrTC

'ITAAATCAGA

TTAAACAGGA

TGCGTATT

AGTGATTGTC

CCTCTATITA

TGTTCTACCA

AGGCAACATC

TAGCCACTGG

CACACCT-GG

ACAGGGCCAG

GAAGAGTAAG

GGAGCTTGTC

GGCTCATT-FT

CAAAT-rCAGC UrATGAGTCT CAAGTT-rTAT TATTGCAATA AAAGTGCTTT ATGCCCGAAT TC GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCTTFCCCC AAGCGCGGCC ACCGGGATGC TTGAAGATGG AAAGAAA1TTT GATTCCTCCC GGGACAGAAA TAGGCAAGCA GGAGGTGATC CGAGGCTGGG AAGAAGGGGT TGCCCAGATG ACTGACTATA TCTCCAGATT ATGCCTATGG TGCCACTGGG CACCCAGGCA CTCGTCTTCG ATGTGGAGCT TCTAAAACTG GAATGACAGG AATGGCCTCC GGATCTGCCR TGGAGGGATC TGGTGCCTCC AGACATGTGC ACATGARTCC YITCCACTCCA CT-JTGTATAG ACATCTGCCC TGACTGAATG TGTTCTGTCA CTCTGYTTCC TCTJTCCCCT[ TCTCCTCGTA TGTGTGTTTA CCTAAACTAT TTCA AAGCTTCTAC CCTAGTCTGG TGCTACACTT ACATTGCTTA TGTGGCTCCT GTTATAACTA TITATAGCACC AGGTCTATGA CCAGGAGAAT ATAAGAGAT-T T-rGCACCTGC AATAGACCTT ATGACACCTA ACCAACCCCA ACAGAGGGAA TACTITTATCC AACTCACACA AGCTGTTTTC CTCCCAGATC ATFTTTFTAGA GATGGGGGCT TCACTATGTT GCCCACACTG GACTAAAACT CTGCCTCAGC CTCCTGAATA GCTGGGACTA CAGGGGCATG CCATCACACC AAATATACAT GGCTfAAACT CCAACTGGGA ACCCAAAACA TTCATTTGCT CCTGAACTAG GCTGGCCACA GGAATTATAA AAGCTGAGAA ATTCYITAAT ATTGAAGGCT CATATGTAAA AATCCATGCC 'rrCC1TrCTC CCAATCTCCA TTCTGGCTGA GGCCTrACGC ATACCTCCCG GGGCT-rGCAC ACACCTTCTT GCATATCCTA CAGAAGACCA GGCTTCTCTC TGGTCCTTGG TAGAGGGCTA GGTGGAGAGT TCTCTCCTGA AGCTCCATCC CCTCTATAGG AAATGTGTTG AGGATCAAGA CTTCTTTGTG CTCAAATACC ACTGT-FCTCT TCTCTACCCT ACCCCAAACT CTGAGGTGAT TTATGCCTTA ATCAAGCAAA CTTCCCTCTTr CCCTCAAAAG TTrGCCAGGAG CTGCCAAGTA TTCTGCCAAT TCACCCTGGA CAGAACACAA CTACAGCTAC TATTAGAACT ATTATTATTA ATAAAYI7CCT 108

CTCCAAATCT

CGCGCTTCCC

TCAATAACTr

ATCGAGTTGA

ACTTGTAGCC

CTGCCAGCCA

TATTAAAGTA

AGTCTCTCCT

AATGAYJTCTC

AGGGCATGGG

AATTGAAAAT

17GTAACCTC

ATACCAACAT

AATTCAAAGG

GCACAAAGAG

TCTCTGTTGC

AGGAATAAGA

GTGGCCAGCA

AGAGAAGACC

TTAGAAAAAT

TTGAGATCAC

GGAACAGGAA

TAGAAGAAAG

CTGTAGTAAA

AAATCTGTTT

TGCTTCAAAA

TTTGTTAGCC

A'ITCCAGATT

ACAGTAATGG

ACATGAAATA

ATTGATCATC

TGGTFTCTTC

TCCAGAGACC

TTCTCCCAGA

GATGTTAGTU

AGCCCC'rrGA CTrCGGATTT CACGATrTCT CCCrCCCC TAGAAACT-rG ATAAGMrCC TTTTCTAAG ACTACATGTT TGTCATCTTA TAAAGCAAAG GGGTGAATAA ATGAACCAAA CTGGAATATC TGCAAACAAC AATAATATCA GCTATGCCAT CTTTCACTAT TTTAGCCAGT ATGAACATAG AAAAATACAA AACTGAATTC TTCCCTGTAA ATJTCCCCG'Ff TTGACGACGC ACGTAGCCAC GCCTACTTAA GACAATTACA AAAGGCGAAG AAGACTGACT CAGGCTTAAG GAGAGGGAGT CATTTCATTG GCGTTTGAGT CAGCAAAGGT ATTGTCCTCA CATCTCTGGC TTTTCTGT7G T7GTTTTTCT CTTTGGCTGT TTTCTCTCAC ATTGCCYITCT CTAAAGCTAC TTCTTTTCTT GTCCCTCCCT GGTTTGGTAT GTGACCTAGA ATTACAGTCA GATfTCAGAA TCAThI'TGCT GATAAGGACT GATTCGFITT ACTGAGGGAC GGCAGAACTA GTTTCCTATG TGAATACAAC TGAGGCTTCT CATGGGAGGG AATCTCTACT ATCCAAAATT ATTAGGAGAA YFCCAACTCT GTCTCTCTCT TACCTCTGTG TAAGGCAAAT ACCTTATTCT TGTGGTGTTT TTCAAACTT-f CATTGA'FrGA ATGCCTGTTC TGGCAATACA TTAGGTTGGG CACATAAGGA AAATAAAACA TTCTAAAAGA AGTTTACGAT CTAATAAAGG AGACAGOTAC ATAGCAAACT AGCTAGAAGA TGGAGAAAAT GCTGAATGTG GACTAAGTCA TTCAACAAAG UTTTCAGGAA GAGGGGCTCC CCTCACAGAT ATCTGGATTA GAGGCTGGCT GAGCTGATGG TGGCTGGTGT AGAAGTCAAG ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGGTA T-FTATCTCTT GTGATTTAAT GAGGGTT7CA AGGCTCACCA GAATCCAGCT AGGCATAACA TGGGGGCAGG CCGGCAGAGG TTGTAGAGAT GTGTACTAGT CCTGAAGTCA GAGCAGGTTC CAGAAAAACT AAGCATTCAG CATGTTAAAC TGAGATTACA TTGGCAGGGA GACCGCCATT TATTTTTGAG GTCTGCTGAG CCCTACATGA ATATCAGCAT CAACTTAGAC ACAGCCTCTG ATGCCCTGAT ATAAGAATGG GTTTTACTGG TCCATTCTCA GGAAAACTTG ATCTCATTCA ATGGCTCCAC AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAAATCT CACTCAGATG GTAAATGAAC ACAAAGATAA AATTACGGAA CATATTAAAC TAACATGATG TTTFCCATTAT TACTAACACA AACTAGGCTG TCAAAATTTT GCCTGGATAT TTTACTAAGT ATAAATTATG

TAGTGAATAC

CCTTTCTT-T

AAGTCCAATT

AGTAAGATAT

CCATGTGTAT

ACAACAATTA

TGTCTCTGAA

ATCCAAAGAG

TGTCTYJ7CAT

ATGAAAGTAA

CTCTAAAGGA

TMACAGATA

GAATTACTCT

GTGTGTGACC

CATTCTCATC

TCAGGTAAGC

TGTGTAACAT ATAATCTATT GCTTAACATT CTTCCCTGAA AAGCACAGGT AAAGCTCAAA ACCTATGTGT ATGTGTAGAA CACAACTATC ATGGTCATTA ATCTTA'TrT GACAGTGAAA AAATGACTGT AATTCTCATG TGGYJ7AAAAT AAAAAGGAAG CTTCAAYITAA AGCTCTrCAA GCCTGTCTTG ATGACTACTA GTCCTTAAAT TTCAAAGATG AAGTACATTG GCCAGAGACC ATGAAGAAGA CAG17CCTCC GGACTGCTAT TCTTACACAG TG'TFTACCC TCACTAGAGA AATAGTTGAT GTGCATTGGC CCTGGGGCAG GCYFCATCAG GTCTGTCTCC TAACGTGATG AACAGCAATG ACTTGAATCT TAAATACTTT TATAAGTGAG ACCAGCTGCC TCTCTAAACT ACAGAGCAGA ACTATCCCAA ATCCCTGAGA ACTGGAGTCT ATGCCATCCT GAGAAAGCCC CGCAGGCCGC TTCACCAGGT TGTTGTGGTT GTCTTCTCTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATGAA GCTGAGAGAG AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG TGUTATTGTG TTTGGAGACC

ACAAATAGAC

ATTTCTAAAA

CCACTCACTA

AAGTCTTCCT

AGGGAAGCCT

CAGCACCTAC

AGAAATCCTT

TATCTCTGAA

AAGGTTCTGA

ATGACTCAGA

AGTAGAATTIT

CTATACAGAG

ACTTGCTCAC

ACTATAAGTA

TATTYITGAGC

CAATCATTGT

AAAAAAATCA

AATGAAACAC

TGAAAGAACT

CTATCATGTA

ACCTCTAAAA

CTGCCTAGTA TGTCTTCAGT ACTGGCTTTA AAAGCTGTCC CCAAAGGAGT AT17GT1'AAGC AGATTTFTAA CCTCCTGAGA GGGAACTAAT TGGAAAGCTA TAACCTATTT AGTrACAACA TCTCATTFT GAGCATGCAA ATAAATGAAA TCTTITT7ATC CTGGAAGGAG GAAGGAAGGT GAGACAAAAG GGAGAGAGGG CAGTTACCTA AGACCAGAAT GGAGATCCTC CTCACTACCT CTG1TGAATA 'TrCA11TCCCT GACCATGAAC AGCCTCTCAG CTTCTGTTTT CCU-CCTCAC AGCTATGGCC CACTCCATGA AGGCTGCATG GATCAATCTG TGTCTCTGAG CATCCAAGCT TACCT[CAAG GAGAGCATGG TGGTAGTAGC AACCAACGGG AGAAGAGACG GTTGAGTTTA AGCCAATCCA TCACTGATGA GGAAGGTAAG GGGTCAAGCA CAATAATATC T[TCT=rAC AGGGGAAAAT TAAACGTGGA GTCAGAATAA CAAGAAGACA GAAAATTAAT YTTTATCCTT CTCCAGGAGG GAGAAATGAG AGCCATTATT TCTTAGCCAT A11TGTAAAGG TCGTGTGACT CAGTAATAAG ACCACTTACG AGCTATGTTC CTCTCATACT AACTATGCCT CTTT-rCGTGA TTCAGTTTCC TCTACTGTAA AATGGAGATA ATCAGAATCC

AAAGATTAAG

AGTCAACATC

ATTACTATCA

GAGTGCAGTG

CCTCCCGAGT

ACGGAGTTTC

AGGCGTGAGC

AGCAATACTA

AGTCTCAGGC TACAGACT CCCTAACTTC TGGACTAGAA TTATTATTAT TAITFIATT-r GAGCTAGCTG GGCCCTCCTG TAATGTCTGG TACAAAGTAA TTrTT1T[G AGATGGAGTC GCACAATCTC GGCTCACTGC AAGCTCTGCC AAGCTGGGAA TACAGGCACC CGCCACTGTr ACCGTGGTCT CCATCTCCTC GTGATCCACC CACCGCGCCC GGCCTATTAT TATT1ATTATr AI117ATTAAT GACTGGATITA TGTCTAAACC

TCCTGGGTTC

CCCGGCTAAT

CACC'FFGGCC

ACTACTACTA

TCACAAGAAT

TGGCATACAT

CTCCTCCATC

TGACCTGGAG GCCATCGCCA AGTITTAAGC AAGTAGGGAC ACCAAGCATr AGTCTGGTAA CAGTGGCCTG AATCGAGAAT TTTAGCCTTT CAGGAGAAAG CCTTGGTCAT GTTFACATAAT CCCACTCATT GGATTGUTGT ACTGTTATAA AGATTAAATG GCACCCAATA AATGTfTAGCT TGGCTCTGTC ACCCAGGCTG ATGCCATTCT CCTGCCTCAG 1TTTGTATT 'rrTAGTAGAG TCCCAAAGTG CCGGGATTAC CTACCTATAT GAATACTACC CCTACCTTCT CATTACAT CTGTAAGTGG GAGAGCCTCA CCT17rACTGT ACAAGCCTCC TAACGCATGT TCACCTAGAA AGTGAGAGTr TACTACTGCC TGAACAAATA TGTCTAACAT GTATTGAGGA CATTTTAGAG TAAATATTCA 1T-CTCTCAC AAAAGGAAAC TAAGCTCATT GAGATAGGTA AACTGCCCAA AATCTAATT1C AGTTCTACCT GAGTAAAAAA ATCATGGTrT ACATGAACTA TAAACCCAAT ATTCCTGTTFI7 YAAGATAAT ACCTAAGCAA GGT1TMAAAA TGTAACAAAA TATAAGAAAA TAAAAATCAC TCATATCGTC AGCACTATGG TATGTTTCCT TAAAATCTTT GCTATACACA TACCTACATG CAAGACCACA CTA1TACAA CTTrTATATCC AGCTTrTCTT ACTTAGCAAT TGCCCGTT7 TCACCATTAT AAGCAATGCA ACAATGAACA TCTGTATAAA 109 CCTTTATC CTTAGAATAT ATrCCTAGAA GTAGAATTTC CCAGAGCCAT GAGGATTTGT GACGCTATTG

ATATGTGCCA

CATTCGTTTG

AAAATGAAAA

AGAAGCACAT

TTTGCT[CCT

CTGTGTATAT

AGCCTAGGTC

ATTCATCCTG

TTACATAATC

TTTACTTATT

ATTCTTCCAG

ATCTGGAAGT

GTACTACCTC

TAAATGAT11T

CAAACTCACA

TCCAATAAGC

TTTTCATGGC

ATAAACAAGC

TATTTTGTGT

YI7GCCATTTT

GCTTGATTGC

CAAAGAGGAA

AAAACTGAAC

GGTCATTATG

CACTTATTCA

CTAGTGAGTG

TACACCATAG

CACAATCTAC

CCAGTGAAAT

TCTCAAAAAC

ITTGTCTCCA

CAAGGTGACA

AGGCGTGCCT

ccTTTCCCTG CT-rTGCACTC

AAAACATAGA

AGTTrGCACAA

AAGCAACAAC

TCTGTGACAT ATATAATTAT TTT-rAATGCA TTCA1TTTT[ CGGGAAATAC TGGTAGTCTr CCT-rGTCAGT TAGAAACACC ATAGTCTCTA AAAACAATGA AACTATTGCC TGAGGAATTG AAGGATAATC CTAGAAAACC AGYJTCTGCTG ACTGGGTGAT CATCTGGATT GGAATATTCC TAATACCCCC CATCTGTGTTr TGTACATAGA CATJTAATCTG ATCACCTrTT AGCTTCCTGA GCAATGTGAA AATGACGCCC TCAATCAAAG TATAATTCGA TGGATGAAGC AGOTACATTA AAATGGCACC [ATTTATTTC AATCTTTCTG CTTGCAAAAA AATAGCTTGA AGCACAGCAC CCCCATAAAA TCCACAAGAG AGAAGT'rfCC TATCTTTGAG TT-rGGTTCTT TCAGACATTC TJ7ACCCTCAA ACTCAGATTf ACCCAGAAGC CAATGAAGAA AGTAACACCA AACCAGGAAG ATCTTTATTA TACAAATATG GCTTAAAGGA TGAAGTTTAG GGACATGTTT TAGTTTCAAC AGTATACATA

TCCAGAACTA

CACTrGTGAT

ATACAACTTT

GCCAATGATC

AGACATTTCT

ACATACCTCT

ATCCCAAGCC

AGTAAAGGGT

TT11TCCCTGT

CATGGTTTA

ATGAGGATCA

AGTACCTCAC

GTCATCCTCC

TCAGAGTTCT

AGGGCAGAAG

TGTGCACAAA

TT117AAAACT GAGGAAACTG CAATCACTCT CCTITTAAAAA TCTCTGATAA CATAI1TTGTG TGTCCAAAAA CTITATCAC TTTTCAAAGG TCCAGAGAGG

TCTCAGAGTG

CAAACAATGA

AAGTTTAAAA

TTCACTTCTC

TUGTACTAGA

GAAATCATCA

TCAAATACGA

GGCTGCTGCA

CCTCCTTTCA

GGGTTGCACA

GTTCAACTAA

GCTAGCTGAT

TCAGACATAT

GTCTGTTGAT

AGGCAAAACC

ACACATCCAA

CAATTTTrGCA

ATTTACAAAT

GTGTATGTAT

ACTCTAAATA

GAGCACATCC

TCTGTAAGTA

CTCCATGTTA

AGAGATTCAA

ATTTACCTGC

AAGACTTT

TCTATTTTTC

TAATATCACT

AAATATCTTT

TGCCTAGATC

TACTTTTCAG

AACTTATGAT

GCCCCGAAGG

TGGAAGACAT

GTGGGGACCT

ATCAACACTT

TTGACATGGG

TCAATTGTAT

ACTTACCTTC

CTGTCCTCT7

AGGCAGGATC

CCTGACCTTA

CTGATTGGAT

TACTTAATAT

AGACAA117CA

GTATATATTA

AATGGGCACA

TATCACTAGC

CTAACAAATT

ATTCATrCAA

GCACTTCAGC

TATTTCTGCA

ATCAGGTTGC

TTGTT-TTTC

AATAATTTGA

AACATATGAG

A.CAGGGTCTrT

CGTAGAAAAT

TAACATGC'FF

ATTflCCCAA

TACGTTGGTC

TCCTATCTTG

CAGCTCTTAT

TGTATCAGCT

ATCCCACTAA

TCTAAGAACA

TCAACTCTAC

TATTGACATC

CCTTGGGTTT

TAATTTCTTT

TAAACATTAT

TCCTAAACCC

TGAAATTATA

TITAACCAAGT

TGTGAAGGAC ACAAAGATGT ATAGAATTCC A'I1TCCTGACT TCCAGGTATT AACTACACAC ACACACACAC ACACACACAC ACACACACAC ACCATGCACA GATT'1fATAC AAATACAATG AATfTACTTT CTJ7YTrGGTT CTTCTCTTCA TGCTTATAAG TCATCAAAGG ATGATGCTAA AATTACCGTG A17CTAAGAA GOACTGCCC AAGATGAAGA CCAACCAGTG CTGCTGAAGG TCAGTTGTCC AT1TTACATCT CATATG=TG TAAATAAGCC CAATAGGCAG ACACCTCTAA TCCTTCCTAC CACAGCCCCC ACCTACCCAC CCCACTCCCA TTGATTCCAG

TATGAGAAAA

TTCACCTCCC

TATAACAGAG AGTAAGAGG TCTATTATCT GACCTACACA ATACTAGACA CAACTGAGAT CAGAGAGGAT TAATCACCTG AATGGGGCCT GCTGCTrCCA GTTCCCCTCT TCTCCACTAC CACTTTCCCC CTCAAACACA TAGGTGACTC AATTTGTAAG TATATAATCC TGCTTTTCTA CCTGGATCAA GTGATGTCTA

ATCCCAGAGC

TTAGGACAAT

CCAATGGGCA

CTCTGCA'rrG

CACACACACA

AAGACCTTCT

CAGAGTAGGG

ATCCATTTAT

GTGGCCTGCC

CAAAGCAACA

ATGTCAGCAT

ACAGCCTI'AG

A17CCCAAGT

CAGTAGCTTC

GCCAACAGCA

A AAATTACC17 CTTTCTTTTT TCCATTGATC TTTACTGACA TCCAAGAAAC TCAAATAAGC AGCTGGGAGC CAAGTCCCAA TATCCTTCGT CCCAGTCCTG ATGTITTCTC CACTGATAAG AGAATTTATG TGCCTGCCTG ATTCATGAAC TCATTCAACA GTGTGGACAG TGGTGCATCA CAACCCAAAC AACCAACAAA GAAAAGTGGG AGAGTGCTAT AGAGGGGGCG GGTCATGGTT AGCATr~ATTC ACTGAGAGCC TfGTATT[TT CAGGCATAGT

AAGCCTCTAG

AGAGCAAGAT

TTrAGACAAAG TCTCATAGAA CTTAGTCTTC TGGAGGATAT GGAAAACAGA GCTGCAAAAA AAAAAAAAAT GAATAGGGTG CTAAGATAGA TGGTAAAAAC AAAGCCCCT1T GTGAGATGAG AGCTGCCGAC GTGGGTT-FTT GGGTAGGACA TTCAGAGGAG GGGGCGGGTC GAGGAGGGGG CGGGTCGTGG TFTGTGGGT TTGGGTAGGA GGGTTTFTGG GTAGGACATT CAGAGGAGGG GGCGGGTCGT TCTGAATGCA CCCAGGCCTA CAACT-rCAAG ATGGTAAAGG GGAACTGGGG CATTTTGAGA AGGAGGAAAA ATATGCAGAG

TCATTTGAGG

CCTAAAATAG

AGTCATGGGG

AACCAACAGA

AAATAAATCC

AGAATAGGAA

CTCATACTCA

GTGTGTATGT

AATGTCATCT

GGGCTFAGAA

AACAATGT

TrFAGATCTCT

TGTAATAAAT

AAGTGGTGTT

CTAACAGAAT

CAACCTCCTC

TACAATGAAA ACCCAYITAAT AAAACAGATC AGAAGGAAGG GTGGGGTAAG GAAAAGAAGT AGGAAGAGGA GAAACAACAT TGCTGACAfl GGAAACCCCA AGAAGCATCT CAACTTGGAA

CAAGAAAAGT

GTGTGTGTGT

AAATGCTAAA

TCACTGTAGT

CCCTCCTACC

CTCCAATCAA

GCTTGCTGAA

ACATI7CTAAA

ATGTGTGTGT

TTGATTTCCC

GCTCAGATrT

TGCCTGGATA

CTAAGGAAAT

TGAACAAATG

GGGTTTCACA

CAATAGAGAA

GGAAAGAAAC

TITACTGAGAA

AGGAAGCCTC

'TTTGAAATCT

GAGTATATTG

GTGTGTTTAA

AAAGGTATGA

GATGCAAAAT

CAGTAAGATA

CAACTCTTAT

AATGAAGAGC

GTGGTTGTGG GTTITTGGGT AGGACATTCA CATTCAGAGG AGGGGGCGGG TCGTGGTTGT GGYITGTGGGT TFTrGGGACA TTCAGAGGAG ACAGCTCCAA GGATCAGAAG AAGCATTCTT ACTAGTGCTT GCAGAGCTTG CAT-17GGATT CAGTGCAATG GCCTGACCTC ACTTATATrT GCAGAAAGTC CAATGAGGAG GITTTCACAGC AGACAGAATT GGGTTATATT TFTGGAGATAG GGGAAAAAGT AGGAGAGGAA TAGrnTrGGG AAAAGTATAT TI'ACTTGCT7 TAGAT[AAA ATITMCCAT AAAAGTATTG U-AAATTCTA AAAGAGT1TA CTGATATACT TAGGAATTTT CC1TCAATTG UTGACTTAAA TACTGAGATA TTITGTTCACT TGGAGATCAA AATG3TIAGG GTCTTAGGCC TATGTJTGAAG GCAGGACAGA CTAGTGTCAC TGACAATCTr CATAACTAAT TAATAGACTG GGCCACACAT CTACTAGGCA CTATAGCATC ATGTTrACAGC CATAGTCCTA TCTCATGAAG GCCAAATGCT AAGGGATTGA GCTTCAGTCC TTICTAAC ATCTTGTTCT TCTCTI7CTTT TCTTCATAGG AGATGCCTGA GATACCCAAA ACCATCACAG GTAGTGAGAC TTCTTCTGGG AAACTCACGG CACTAAGAAC TATTTCACAT CAGTTGCCCA TCCAAAC11TG TrTATTGCCA CAAAGCAAGA CTACTGGGTG TGCTTGGCAG GGGGGCCACC CTCTATCACT GACTTTCAGA 110 TACTGGAAAA CCAGGCGTAG GTCTGGAGTC TCACTTGTCT CACUTGTGCA GTGTTGACAG TTCATATGTA CCATGTACAT GAAGAAGCTA AATCCTTTAC TGTTAGTCAT TTGCTGAGCA TGTACTGAGC CTTGTAATTC TAAATGAATG TTTACACTCT TTGTAAGAGT GGAACCAACA CTAACATATA ATGTTGTTAT TTAAAGAACA CCCTATATTT TGCATAGTAC CAATCATTTT AATTATTATT CTTCATAACA A=TAGGAG GACCAGAGCT ACTGACTATG GCTACCAAAA AGACTCTACC CATATTACAG ATGGGCAAAT TAAGGCATAA GAAAACTAAG AAATATGCAC AATAGCAGTT GAAACAAGAA GCCACAGACC TAGGATTrCA TGATfTCATT TCAACTGTTT GCCT-rCTGCT TTTAAGTTGC TGATGAACTC TTAATCAAAT AGCATAAGTT TCTGGGACCT CAGTTTTATC ATTTTCAAAA TGGAGGGAAT AATACCTAAG CCTTCCTGCC GCAACAGTTT TTTATGCTAA TCAGGGAGGT CATTTTGGTA AAATACTTCT CGAAGCCGAG CCTCAAGATG AAGGCAAAGC ACGAAATGUT ATTTYFTAAT TAUTATTTAT ATATGTAT-rT ATAAATATAT TTAAGATAAT TATAATATAC TATATTTATG GGAACCCCTT CATCCTCTGA GTGTGACCAG GCATCCTCCA CAATAGCAGA CAGTGTTTTC TGGGATAAGT AAGTTTGATT TCATTAATAC AGGGCATTTT GGTCCAAGTT GTGCTTATCC CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT GTAATCATAT AATAAATGTA CATTAATTAC CTTGAGCCAG TAAFUTGGTCC GATCrTYGAC TCTTTTGCCA TTAAACTTAC CTGGGCATTC 117GTTTCAYJ7 CAATTCCACC TGCAATCAAG TCCTACAAGC TAAAATTAGA TGAACTCAAC TrTGACAACC ATOAGACCAC TGTTATCAAA ACTTTCTTTT CTGGAATGTA

ATCAATGTTT

TTGATAGAGT

GCCTTAATCA

AGTGT-TAC1T

AAATGGCATT

TTCCCATCTT

TCAGACCTGT

GGATTCTCTT

AGTGAAATGA

TGAAGTGCTC

CCACTACAGC

GTTCCCTGCC

CTTCTAGGTT

GTTATCAGTC

TFATTYJ7ACT

CTAAAAATTG

ATAACTAAAT

GCATGGTAAT

TGATCAGACC ATAATGTTAC AAAGCTTGCA ACAAAATTCT TAGGGACAAA TGGTAAATGT TATAAAATCA AACCAAGATFT TTrATA'TFTTf TTCTCCTCTT AAGAATGATA ATATTTCCGG GTTCACTTAA AGCTCATATT TATACAAACT CACACATACA GAGCTACATT AAAAACAACT AATCCCAGCA CTT-rGGGAGG ACCAACCTCT TCGAGGCACA CAGCCAATCT TCATTGCTCA AGTGTCTGAA GCAGCCATGG

ATTATTATCA

CTGACACATA

TTACATAAAT

TGTTAGCTGC

ACACATACAC

AATAGGCCAG

AGGCACAACA

CAGAAGTACC

AGCTGATGGC

CAGCTACGAA

ACAAGCTGAG

CTTCATCTTT

GTACGATCAC

ACAATAGTGA

GTTATrCATT

AATTGTATTT

CAGTATGCAT

AAAACATGTG

GCACGGTGGC

*GGCTGCTCTG

TGAGCTCGCC

CCTAAACAGA

TCTCCGACCA

GAAGATGCTG

GAAGAAGAAC

TGAACTGCAC

TGGCTTATTA

CTI7CCAGGAC

AAGGGCTTCA

CACAGACCTT

CTATCTTCTT CGACACATGG GCTCCGGGAC TCACAGCAAA GGACAGGATA TGGAGCAACA TACCTGTGGC CTTGGGCCTC TCTACAGCTG GAGAGTGTAG

CAGTGGCAAT

CTGGACCTCT

GGCAGGCCGC

CCAGGAGAAT

GATAACGAGG

AAAGCTTGGT

AGTGGTGTTC

AAGGAAAAGA

ATCCCAAAAA

GAGGATGACT

GCCCTCTGGA

GTCAGTTG17

GACCTGAGCA

CTTATGTGCA

GATGTCTGGT

TCCATGTCCT

ATCTGTACCT

TTACCCAAAG

TGTrCTTTGA

TGGCGGCATC

GTGGCCATGG

CCTrCTTCC

CGATGCACCT

CCATATGAAC TGAAAGCTCT CCACCTCCAG

TFTGTACAAGG

GTCCTGCGTG

AAGAAGATGG

AAGATAGAAA TCAATAACAA GCTGGAATTT AAGCAGAAAA CATGCCCGTC U7CCTGGGAG ATTTrGTGTCT TCCTAAAGAG AGCTGTACCC GGCAGAAAGG GAACAGAAAG GTTTTTGAGT GAGTCTGCCC AGTTCCCCAA GGACCAAAGG COOCCAGGAT AGAGAGTCCT GTGCTGAATG ACGGCTATAG CCTGGAC3TrT

AGAAGAAAGT

TTGAAAGATG

AAAAGCGATF

CTGGTACATC

ATAACTGACT

TGGACTCAAT

CCTGTTGTCT

CCAACTGCCT GCCTrFAGGGT TTCAGGGCCA ATCCCCAGCC CTGACAGAAA CCACGGCCAC ACCGCTTCCC TATTITATTTA AAGAAGTAGC AGTGTCTGTA TGCTCTCTTT AAATCAAGTC TITTATAAATG AGCAAATATC AGAGAGAGAA AGAAAAGAAA YITCCTACAAC GGGAGAACCA AGGCCACCCA GACAGGGCTT AATGGATTAT GGCYI7ATCAA TATAACTTAC TAAAGATGGA TCAGAAGGCT GCTTGGAGAG TCTCAAATAC 'FGCACAGAG ATTTGAATAA AATGCTGTCA ATGCCAGGCA CTGTGCTAGA TCAACTCAGT GCTATAAGAA AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA CT-rTTGTTGA GCCAGGCCTC TCTCACCTCT CCTACTCACT ATTTGGTTCT AAGAAACCCT CTGTCATTCG CTCCCACATT TTTATTTGTT TGTTTGTTYJ7 ATTCATTGGT CTAA1TTATT AAAGAGCCTA G11TrTTAATA GCTATGGAAT CAATTCAAT[r CT-rTAATTAA GACTGAAAAT ATATAAGCTC AGATTATITTA ATACTGTTCA ATGGTTCTGA AATAAACTTC TCTGAAG GAGGAAGGAA GGAAGGAAGG AAGAAAGACA GGCTCTGAGG GTGGTTAATT TGCAAAGTGG ATCCTGTGGA GGCANNCAGA TTAGCTATCT GCAGGCCAGA CACCAAATTT CAGGAGGGCT ATTCACAGGA AACTAACATG TTGAACAGCT TTJTAGATTTC GTTCTTGTGA CTGACTCCTG ATATCAAGAT ACTGGGAGCC CAAGTCCATG AAATGCTCTT MTCCCACAG TAGAACCTAT GCTCACTCCC YITGGATAATG CAGAGCGAGC ACGATACCTG AATTCCCATT CACCCATTCA AGCAGCAAAC TCTATCTCAC CTTGGCTCAA AAAGATTTCA G1TrCCTGGA GGAACCAGGA

AATGACAAAA

ATAAGCCCAC

TGTCTTCAAC

AGCACCTCTC

TCACCATGCA

CCCTAGGGCT

ACACCAATGC

GCTCTCTCCT

TAAAGCCCGC

CTGATGAGCA

CAAAGGGGGC

TGGACTGGTG

AATGGGAATA

AGAAAGAAAG

AAGGTGGCAG

GGAGTCCCCT

CAGTGTTAGG

CTGTGGAAAA

AAATTAAAAA

TTCCCTCGTG

GCACATACTA

CTGAATGTAC

GGGCAAGGTT

GTGTITACAGG CTGGACACGG AGGCCGAGGC GGGCAGATCA CAAGGTCAGG AGATCGAGAC CTACTAAAAA TACAAAAAAT TAGCCGGGCG TTGGCGGCAG GAGGCAGGAG AATGGTGTGA ACCCGGGAGG CGGAACTTGC GCCTGGGCGA CAGAGTGAGA CTCTGTCTCA AAAAAAAAAA GGCAAAGGAG GGTGTTCCTA CACTCCAGGC ACTGTTCATA GGGCTCCCCT GGGCAGATCC CTGGAGCAGG CAC1TTGCTG TTrGGTATTAC CAAGAGATAG AGTCTCAGAT GGATATTCTT CACCAAAAAA TCATTITAGG CAGAGCTCAT CTGGCATTGA ACAGCACCTG GTCTTGCAGG GYI7GTGTGAG CYJ7ATCTCCA CCCTGCATAC CGTATGTTCT CTGCCCCAGC CAAGAAAGGT ACAGAGAGCT CCCGAGGCAG AGAACAGCAC CCAAGGTAGA TGGCTCACGC CTGTAATCCC AACATTTGGG CATCCTGGCT AACATGGTGA AACCCTGTCT GTGCCTGTAG TCCCAGCTGC TGGGGAGGCT AGGGGGCCGA GATCGTGCCA CTGCACTCCA AAAAGTGT1'A

ACCTGGACTC

GTGTCTCGGT

ACAGAAACAA

TCTGGTTCAT

GGGTTGCCCC

CAATTTTCTC

GACCCACACC

TGATGCAGAC

TCATTCATTC

TAAAGAGAAA

TATTCCCACT

CCATGAGATT

AACTCCGTCA

CTCAGAGGCT

CTCAATACAG

CTGTCAAAGA

TACAAATGGA

CTGATAACTC

TTTCAGAGTT

GGCTAGGGTA

GGAGCCTGAA

CCTGCAATTG

ACAGGGAGGG

CTATTGGCCC TJTCAT-rGTAC CCAn-TATCC ATCTGTAAGT GGGAAGATTC CTAAACTTAA GTACAAAGAA GTGAATGAAG AAAAGTATGT GCATGTATAA ATCTGTGTGT CTTCCACT-rr GTCCCACATA TACTAAATTT AAACATTrCTT CTAACGTGGG AAAATCCAGT AT-rTTAATGT GGACATCAAC TGCACAACGA TTGTCAGGAA 111 AACAATGCAT ATTTGCATGG TGATACATTT AACCAGAGAA TTATCTCAGT TrATTAGTCC CCTTTAACTr GATTGTGAAA TCAGGTATTC GCTATAAAAA CAGCGAGGGA GAAACTGGCA TCTGGGATTC TCTTCAGCCA ATCTTCATTG GGGAGTCTCT CTGTCTCTCT GCCTCTT[GT TCTCTCCTCT CCTTCCTCTC TGCCTCCTCT GCAAAATGTG TCATAGTTTG CCTCCCCTAA GAAGCTTCCA AACAGAGAAA TTTCTCAGCC GATACCAAAC CTCTTrCGAGG CTCAAGTATG ACTTTAATCT GTGTATGCAT AT-rCTCTCTC CTCAGCTTTT TGCAAAAATG CTGCTTATCT AACAGCTGAC ATTGCTAGTl GGGGTTTGGT TTCATTTACT CAGAGATCAT

ATGACTCGGG

AGCCTCTGCT

GACCCAAAGG

CACTGGATGC

CACAGGTGTC

AGTGGAGACG

AGACCAGATT

cTAcTTCCC

TCCTGCAGAG

TFGGAGGGAG

AGGGAGCACC

GAAACTTGCC

TTGTACACAG

GTGGCAATGA

ACTCCCAACC

CATGGTATfT

GCCACTTGGT

GGGGAGGAGT

ATCCTfTTAA

GAGAACTAAC

CAAGACATAG

CTTGACAAGT

ATTCCAGCAT

GGTCAT-rTTT

GCTCAGTAGC

TTTTCTCTGG

GTTAAAAACA

ATTGGCTTGT

ATTCTCTCCT

TTrATCAGCCT ATTJ7CACAAA

AGAACAGTGT

ATGAAAAAGC

TGTAGGTGGG

GTCCAGAAGC

CCTrGAGCTT c3TTTTATGAG

CCTCCACCTC

CACCACACCC

AAGTCCTGAC

GCCTGGCCCA

TCTACTCTCT

GCAGTGCTCC

CACTACAGCA

TYUCCCTGCCC

AAATATTCTG GGAATGGATA CCAGCTCTCC TAGCCAATAC ACTTCTCTr CACACATTCA CTACTCCTTG CCCTTCCATG CCAATACTCT TTCCCCTIT TCCTACTTCT GCTTTTGAAA CACAAGGCAC AACAGGCTGC TCCTTACAAC TAGGTGCTAA TCTCTCTCYr TCTrCTCTG CCAGGTGTAA TATAATGCT[ ACCCTAAAGG UTAGTGTCAA TTAGCAAATG CTTTTCTCTA TTCTTTGCAT GACTGCCATG CACTCATT1r CTCCTTTTA ATGATGGCTr ATTACAGGTC AGAGTGTTAT CTGTGCTTGG AAGTAAATCT GATTTAAAGA GATGTGTTGT TGCAAGGGCT ATCCCTTrTGC AAAGTGTGGC GT-rAGGCCTC AAGATCCAAC TGTTCTGCGC ATATCACTGT TTCTTATGAA CAGTCAAGTC

TGAGAGAAAT

TGAAGCAGCC

CACACATGAA CGTAGCCGTC ATGGGGAAGT ATGGCAGAAG TACCTGAGCT CGCCAGTGAA CTGAGACCAG TAACATGAGC AGGTCTCCTC TrTCAAGAGT TTTCCCCTAA ATF7GCCTCTT TCAGTGGCAA ACAGGGTOCC ATTACAAGTC CCTCCAGCCT TGGGACCTGG AGGCTATCCA GCAAATGGGG AGAAAAGATT CCAAGCCCAC AATACAAGGA AGGGAGAGCT CAGATTTTAG CTGACTCTGC TGGGCTAGAG AGGGTGCCCA CCTGCCAGGC CTAGAATCTG CCTrCTGGAC AGGTGTTTCA GGCAGCTTTG AGAGGCAGGC TGITI'GCAGT GGAAGGAAAA ATAAACCTGT ITAGAAGACA TAATTGAGAC ATGTCCCTGT TTTTATTACA GGATGACTTG TTCTTTGAAG CAAGGAAGGG CTCTAACACA TGTTTTAGAA AGACTTrAAC CATCATATCA CCACAGTCAC AGTGATAATG TrCCCATTTC CTGATGGCCC TAAACAGATG AAGGTAAGAC TATGGGTTTA GGGAAAGCTC AAAGAAGGGA GTTCTGGGCC ACTT-FGATGC CTCTTCCAGT GAGACACAGO CTGCACCACT TGCTGACCTG TCACTAACGT TGGTGGTGGT GGCCACACTT GGTGGTGACA ATAGTAGGAA GACAACCAAG TCTTCAACAT AAATrTGATT CAATCACTTG AGTTAAACTC TGAAACCAAG AGATGATCTT TAGAATAG11' T=rGCTACC TGGGGTGAAG CTrATAACAA

GAGATGGATT

ATATGTCTAC

ATGATATAAA

CAT17TACCC

CCTGCAACCT

CAGACTCATC

C'rrCCTAGGT CTTTAT1TTTA TATTTCTT-fA

CTGCCTGGCC

GCTCAACT[

TAAGGCAACC

AAGTACTCTC

CAGCCTATGC

CCCTTrrTGAG CAAAAAGATG AATTGAGACT TGAAAGAAAA CCAflCACTT GCTGTTTGAC GC'TrGGACC

CCAGT'TCTGA

CTTACAAAGA

GCCCAGCCAT

TJTCCAGTTTG

GAAGTI'TTAA

ITTGCCCCCC

CTTTTGTGCA

TCAGTGAAGC

TCATCTGAAA AATAAAGGGC TGAGCTGGAT GATCTCTGAG AATATTTTCA GTTGTAGCTA AGGGCATI'TG GGCAGCAAAT GCCATGTTrAT ATTCCTGCTG TCCCTTCTGT TTTATATGAT CAGCCTAGCT AGGTCAGTTG TGATAGCCTC CCCTAGCCTC GACTGGCATA ACTTCTTGGC ATTGCCTCTT CCAGCAGCTT CTTACAGGTC TC1TAACTG CTTAATACGG AGCTTCTCTG

TGCAGGTTGG

ATAATCCAGT

TGCAGCTGTG

GGCTCTGCTC

TCTTTCAAGC

AATAAGAGGA

GTTATGAAAA

AGGCAGCCAC

CCTCAATCTT

GGAGGAGCCC

CAGGCAGGAA

CTrTGAACCA

AAGTGGTAAC

AGGAAAAAAA ACAGGATTTG CAGAATGCCT ATGAGACAGT AGAAAAATTG AATACTTGCT GAGTGAGCAT AGGTGAATGG AAAATGTTAT GGTCATCTGC AAATCATAGT GTGACAGCAT GCATGTACAA AAAGATGACA CACATTCTAG TCTTGAGTCT CAGAGAGOGA TAATCITTT ACAGAGTCTC 'ACTCTGTTGC CTGAGTTCAA GCGATITCTCC AGCTAATTTT TGTATTTTTA CTAAATGATT CATCCACCTC GAGAGGGATG ATCTYJTAGAA TAGGGATACA AAAAGATATA AGTAGAATCG GGATTTATTC GCCTCTACCT GCTGTGTGCC ATTTTATTTT A1TTFATlTTT CCAGGCTGGA GTGCAGTGGT TTFCCTCAGTC TCCTGAATAG GTAGAGAAGG GG1TCGCCA GGCUTCCCAA AGTGCTGGGA GAGAAGGTAT ACATGTATGG TAAAGAATAG CCTGTAAGGT CUTGAGTACA CCCTrAACCT GTTTTGTI' G'TfTGTTTT ACAATCTTGG CYITACTGCAT CTAGGATTAC AGGTGCACCC TGTTGGCCAG GCTGGTI7TTG TTACAGGCAT GAGCCACCAC GCTCGGGATT C1TCAAGCC CTTTCCTCCT CTCTGAGCTT

GATGTCAAAG

TfCCAGGACC

AGGGCTFTCAG

ACAGACCTTC

TTAGCCAAGA GCAGGCAGTA TCCCCCAGAG CCAAAGCCCT AAAGCAATCA TCTCTTTAGT CTCACTCT[ CTCAGGGGCC TATGACCATC ACCAT'I1TAC GGAACCCATG TCTAATAGTG GTITGTCATCA GACTTTGACC CGAGGCCTGC CCTTCTGAT7 ACATGGGATA ACGAGGCTTA AGCAAAAAAG CTTGGTGATG CATGGTTCCT GGCAGGACCA CCTCACCAGG TGGACCTCTG CCCTCTGGAT GGCGGCATCC GCAGGCCGCG TCAGTTGUTG TGGCCATGGA CAGGAGAATG ACCTGAGCAC CT7CTTTCCC *GATCTCCACT TGTGTCCTCT TGGAAGTCAT FTAAAGGTAG AAGGCCCAGC GGGGAGACAA.

GGAAACTATT CTTAAAGAAG ATCTTGATGG TTCACTTAC AT[GTCACCA GAGGTTrCGTA CTAAGTAGCT CTGTTGCTCG GCCACAGTGA TCAGGTCCAG TGTFCTTAGC CACCCCACTC GTATATGCTC AGGTGTCCTC CAAGAAATCA TTATACCTAA ACAACATGTG CTCCACATTT TGTGCACGAT GCACCTGTAC GATCACTGAA

CTCCCTCCCT

AGCTACGAAT

CAAGCTGAGG

TrrCATC'rrTG

CAAGCCCCAG

AACAAAGAAG

CTACTGACAT

ACCTCCCTGT

GCAGTAATAG

CCAGCT-rCAT AATTrGCCA

CAGAACCTAT

CTGCACGCTC

CGCTCTCTCC

CTCCGACCAC

AAGATGCTGG

AAGAAGGTAG

CCAACTCAAT

GCTGGAAACC

'ITGCAACTCC

GGGCTAGTGT

ACCTGAAGCT

CCCTACTGGT

CCTCGCCTCA

CT17CTTCGAC

CGGGACTCAC

TCTGGTCCAT ATGAACTGAA AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGTT-r CCCTGCCTGG CCTCCTGGCA GCTTlGCTAAT TCTCCATGTT TTAAACAAAG TAGAAAGTTA ATFTAAGGCA AATGATCAAC ACAAGTGAAA AAAAATATTA AAAAGGAATA TACAAACTIT GGTCCTAGAA ATGGCACATT TOATTOCACT GGCCAGTGCA TITTGTTAACA GGAGTGTGAC CCTGAGAAAT TAGACGGCTC AAGCACTCCC AGGACCATGT CCACCCAAGT CTCTTGGGCA TAGTGCAGTG TCAATTCCTTC CACAATATGG GGTCATGA TGGACATGGC CTAACTGCCT GTGGGTrCTC TCTTCCTGTT 112 GTTGAGGCTG AAACAAGAGT GCTGGAGCGA TAATGTGTCC ATCCCCCTCC CCAGTCTTCC CCCCTTGCCC

CAACATCCGT

CTCTCCGCTG

TCGTGCCACA

CTCACTCAGG

AGAGTGATCC

AGCCACTC

TTCTGGTGCC

TCCGCTCCTG

TAAAATGTAG

GGGGAAACCC

CCAAGGAACC

TGGGGTGACC

CTfrGTACAA

CTGTCCTGCG

CCTTCTCAGC

GCTGGGAACA

CAACCT-rCAA

CCCAACAGAT

GTCCCATTAT

T-rCATTTCCA

ACTTCAAGAA

AGCATTrTGGC

GTTACAACTC

AACATCTTTC

TAGATCCCAA

CAAGCTGGAA

GTCTTCCTGG

GAGAGCTGTA

AAGGTTY[rTG

GGTAGTGCTA

GCCC=T1GT CACATT-rGGT TrATTTAfT

TGTAAAAGAG

AGTCCTTrTAA

TATCATACTG

TGACTGTCTG

ATTGCTGAGT

TATTTCGTTG

TCAGGACTGG

GTACTAGGAG

TATAAGCAGA

GGAGGAGAAC

TGGGTGTCGG

GTTCAAGACC

TCAGCCAGGC

GCCCAGAAGT

AGGCAAAAAA

CAGAAGTACC

AGCTGATGGC

CAGCTACGAA

ACAAGCTGAG

CTTCATC1TT

GTACGATCAC

TGAAAGCTCT

AGAAGAAAGT

TTrGAAAGATG

AAAAGCGATT

CTGGTACATC

ATAACTGACT

TGGACTCAAT

CCCACCCAAT

TAACGGGCAA

GTAGCCAAAG

GGGAAGCTAT

CAGGGCCTCC

CCAGCTCAGC

TGATTTCTGG

TGGATGGGCA

ACCCTCTTTC

TAAATCAAC/

TCACTGTGGG

CTGCATGCTG

GGAGAAGAAA

TGTTGAAAGA

CTCCTGCTAC

GGTCTATTTG

TCCTGCTGCA

TATATATTGT

CACGTCCACT

AGTTGATGTC

GCCAGGTGGT

AAGTTTCAAG

CCTCTGCACA

'TGCTCTCAG

AATTGACACT

CTCTCCTCTC

CAGAAGTACA

CATTGCCAGC

TCCTfrGTAGG

TGCGGTGAAC

GGAGTGTGGG

CCAGGCCAAG

GCTGTGACTG

CCAGT11TCT-r

GCTTCACCTC

CAGTGACACA

GAAATTTTAC CGCCCAGCAG GAACTTATAT CCATCATrAG CTGTGGTGAT CTGCCTGGCA CAACTAAGGC TGCTGACTTT GAAGGACAGC AAAATCCTGT TTCTTTGGAA TCGGGTAGTA AGGAAGATCA AAATGAGTGT CTCTCTYJTGG CCCATGGGCT ACTCTCTGTT CCTGAAACAG TTTCCTTTCC TTCCACATTG ATCAAGTJTGT ATGGCY17CCT TCCTTCCTTC CTTCAGCATT TGAGGCTCTG AGAAACCCTC AGGCCTTTGA GTGAGAAGTC AAGTrATCCT GTGTCTTAGG AYJ7CTCCGTfr CCTACTGCTA AAATGACCCT GCTATTGTCT TTCCCACAGA GGCTACCAAT TACATGTATC TGTCCCTAAC CACAAGACCC CCTTFCTCT GTAATGACAA AATACCTGTG GCCTTGGGCC TGATAAGCCC ACTCTACAGC TGGAGGTAAG CACTTATTCC CAGACAATTC ACCTTrCTCCC ACAAGTTITG CATTAATGTA AATAAATJTA GAAAATTAAA TCATTYUGCC GATGTTATTA TAGGGCTGCT CTCA1TJ7GAT AGACACCYI'G CCACTCCCAA AATCACCACC ACTATCACCT ATTrCTAGGAC CATAAGGAAA AATACAATAA CTACTCTCGG GGCTAGGGGT TCAGTGGTGT TCTCCATGTC TCAAGGAAAA GAATCTGTAC TGAATGCTAT GGAATGAAGC CGCCCCCATC CCTAGGAAAA ACATAATTTT TAACTGCGTG TGTCCTACCA TAGTTACAAC GGAAATAGAT GACTTAAAGG CCAGCTTTCT CAGCAAAAGC AAAGCCCCTG GAAACTAGGT GCTCTAGCTT AATTTTCACC CCCCCAAAAA AAAAAAATTC TCACCTACAT TATGCTCCTC ACTAAG1TFIT AGAAAAGAAG AAGGGCTCTT TTAATAATCA CACAGAAAGT TGGGGGCCCA AGGAGTCTGG CTCCTGATCA TGTGACCTGC TCGTCAGTTT CCTTTCTGGC CAACCCAAAG CCATAGGCAT CUrTGTCCCT TGCCCCACAA AAATCTTCT TrCTCTTTCG CTGCAGAGTG AAATTACCCA AAGAAGAAGA TGGAAAAGCG A1TGTCTTC AACAAGATAG AAATCAATAA TTTGAGTCTG CCCAG'FrCCC CAACTGGTAC ATCAGCACCT CTCAAGCAGA AAACATGCCC GAGGGACCAA AGGCGGCCAG GATATAACTG ACTTCACCAT GCAATTTGTG TCTTCCTAAA CCCAGAGAGT CCTGTGCTGA ATGTGGACTC AATCCCTAGG GCTGGCAGAA AGGGAACAGA AGTACGGCTA TAGCCTGGAC TT-rCCTGTTG TCTACACCAA TGCCCAACTG CCTGCCTTAG AGAGGATCTC CTGTCCATCA OCCAGGACAG TCAGCTCTCT CCT-rTCAGGG CCAATCCCCA TGAGCCAGGC CTCTCTCACC TCTCCTACTC ACTTAAAGCC CGCCTGACAG AAACCACGGC TCTAAGAAAC CCTCTGTCAT TCGCTCCCAC ATTCTGATGA GCAACCGCTT CCCTATrTAT GYI7TGTTTGT 'FTrGATTCAT TGGTCTAATT TATTCAAAGG GGGCAAGAAG TAGCAGTGTC CCTAGTTJTTT AATAGCTATG GAATCAATTC AATTTGGACT GGTGTGCTCT CTTTAAATCA TTAAGACTGA AAATATATAA GCTCAGATTA T'rrAAATGGG AATATrATA AATGAGCAAA TTCAATGG117 CTGAAATAAA CTTCACTGAA GAAAAAAAAA AAAGGGTCTC TCCTGATCAT GATTGACACT GACAGTAAGC AAACAGGCTG TGAGAGTTCT TGGGACTAAG CCCACTCCTC GCTGCAAGTA CCTAGAAATA TCCTTGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCT7 UTCAACAGAA GGATATI7CAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGGAG TAGTAACAGC TACCATGATT TATCTATCAA TGCACCAAAC ATCTGTTGAG CAAGCGCTAT CTGGGAGTAC AGAGATGAGA ACAGTCACAA GTCCCTCCTC AGATAGGAGA GGCAGCTAGT ACAAGGTAAC ATGACAAGTA GAGTAAGATA GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GACATAAGAA TCAAGCCTAA AGGGATAAAC AGAAGAYFTC TTACGCCTGT AATCCCAGCA CTTTGGGTGG CAGGGGCAGA AGCCTGGGCA ACATAGTGAG ACTCCCATCT CTACAAAAAA ATGCTGGCAT GCACCTGTAG TCCTAGCTAC T[GGGAAGCT TCAAGACTGC AGTGAGCTTA TCCGTJTGACC TGCAGGTCGA C GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCAATGCTCA TAAGCTCGCC AGTGAAATGA TGGC11TATTA CAGiTGGCAAT CCTAAACAGA TGAAGTGCTC CTJ7CCAGGAC CTGGACCTCT TCTCCGACCA CCACTACAGC AAGGGCYITCA GGCAGGCCGC GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT CACACATGGG CTGGGCCAAT AAGATCGCTT GAGCCCAGGA TAAATAAATA AATAAAACAA GACACTGGAG GATTGCTTGA ACAAACCTTTF TCGAGGCAAA AGTGTCTGAA GCAGCCATGG GAGGATGACT TGTTCTTTGA GCCCTCTGGA TGGCGGCATC GTCAGTTGTT GTGGCCATGG GACCTGAGCA CC1TCTTTCC CTTATGTGCA CGATGCACCT GATGTCTGGT CCATATGAAC TCCATGTCCT TTGTACAAGG ATCTGTACCT GTCCTGCGTG GAAGAAGAAC CTATCTTCTT CGACACATGG TGAACTGCAC GCTCCGGGAC TCACAGCAAA CCACCTCCAG GGACAGGATA TGGAGCAACA AATGACAAAA TACCTGTGGC CTI7000CCTC ATAAGCCCAC TCTACAGCTG GAGAGTGTAG TGTCTTCAAC AAGATAGAAA TCAATAACAA AGCACCTCTC AAGCAGAAAA CATGCCCGTC TCACCATGCA AYITGTGTCT TCCTAAAGAG CCCTAGGGCT GGCAGAAAGG GAACAGAAAG

GATAACGAGG

AAAGCTTGGT

AGTGGTGTTC

AAGGAAAAGA

ATCCCAAAAA TTACCCAAAG AAGAAGATGG GCTGGAATTT GAGTCTGCCC AGTITCCCCAA 17CCTGGGAG

AGCTGTACCC

G'ITTTTGAGT

CCTGTITGTCT ACACCAATGC AGGACAGTCA GCTCTCTCCT CTACTCACTTr AAAGCCCGCC CCAACTGCCT GCCT-rAGGGT AGTGCTAAGA TTCAGGGCCA ATCCCAGCCC 1T~TGTTGAG TGACAGAAAC CAGGCCACAT TTTGGT-rCTA

GGACCAAAGG

AGAGAGTCCT

ACGGCTATAG

GGATCTCCTG

CCAGGCCTCT

AGAAACCCTC

CGGCCAGGAT

GTGCTGAATG

CCTGGAC'rrT

TCCATCAGCC

CTCACCTCTC

CTCTGTCATT

CGCTCCCACA TTCTGATGAG CAACCGCTTC CCTATTTATT TATTrA1TG TTTGTT-rGTT TTGATTCATT GGTCTAATTT ATTCAAAGGG GGCAAGAAGT AGCAGTGTCT GTAAAAGAGC CTAGTTFTTA ATAGCTATGG 113 AATCAATTCA ATTTGGACTG GTGTGCTCTC TTTAAATCAA GTCCTTTAAT TAAGACTGAA CTCAGATTAT TTAAATGGGA ATATTTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TTCACT CTGGCAGGAG TAGCAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT

AATATATAAG

TCAAATAAAC

AGAGAAACAC

AGACACGCCT CATAGAGCAA TGCCGTCCAC CACTGCCCAC ATCCGGCAAG GGCCTGCGAT GTGACGTCCA CT-rCTAGAAG ACAATATTAT CAATACACAG AATACGAAGG ATGGAAAATG GAATCAGAGA ATGAAAACCC CACAGAGGGA GCAGTACCTG CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG AGCYFrTCGCT ACTGTCGTTT GCTGCCATCG CAGACCTGCT GCTGACTTCC ATCCCTCTGG T-ITGACAATG TCAAGATTTA CCGTATATCC CTGT7TGTTF GGATACACCA ACAAAGTTAT AUTACTTAAA CAACCAAAGA TATGAAACTA TCCATGAAGA CAGTCTTITG TAACCATGCC CAATGTGATT GTACCAGATA TTGAAAAGGA GAGCATGCAG CTCCTTTTCT GAGGATGATG ACAGTGCCTC TACATCTGAA TCATGCAAGG GGTTCCTTTA GTTATAAGTC ACTCAGAAAG OGAGGACCAT CCTGGTGCCA TTGCCATT-TT TAATGTGAAC AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG AGCAAGTCAG ATGATAAAAA CGAAAATAAA

AACGACCCAA

GTTACAGTGA

TGTAAGCTAT

AAAACATCCA

GACGG~rGAG

AATCATCAAG

AAATACGAAT

CTGCTGCAT-r

TGCTAAAATT

CCAGTGCTGC

TCTGGGAAAC

GCAAGACTAC

GCGTAGGTCT

AAGCTAAATC

CACTCTTfrGT

TAGTACCAAT

CCAAAAAGAC

GCAGTTGAAA

AGTTGCTGAT

GGGAATAATA

ACTTCTCGAA

GTATTTATAA

GACCAGGCAT

CATTTTGGTC

TCATATAATA

ACTTACCTGG

CTCAACTTTG

AGGTTCTAAA

AGAAGAAGAT GGAAAAGCGA ATGGCCAAAG TTCCAGACAT GTrTGAAGAC CTGAAGAACT AAATGAAGAA GACAGTTCCT CCATTGATCA TCTGTCTCTG

GGCCCACTCC

AGCTTACCYI7

TTTAAGCCAA

CCTAGGTCAG

TCATCCTGAA

ACATAATCTG

ACCGTGATTC

TGAAGGAGAT

ATGAAGGCTG

CAAGGAGAGC

TCCATCACTG

CACCTTTTAG

TGACGCCCTC

GATGAAGCAG

TAAGAATCTC

GCCTGAGATA

CATGGATCAA TCTGTGTCTC ATGGTGGTAG TAGCAACCAA ATGATGACCT GGAGGCCATC

AATCAGAAAT

TGAGTATCTC

CGGGAAGGTT

GCCAATGACT

ACAACT[TAT

CAATGATCAG

TATAAGTCAT

CTGCCCAAGA

CCTTCTATCA

TGAAACCTCT

CTGAAGAAGA

CAGAGGAAGA

GAGGATCATC

TACCTCACGG

CAAAGGATGA

TGAAGACCAA

CTrCCTI(iAGC

AATCAAAGTA

TGAAATTTGA

AAAAACTCAA

CCCAAAACCA

AATGTGAAAT

TAATTCGAGC

CATGGGTGCT

TTGTATGTGA

TCACAGGTAG TGAGACCAAC CTCCTCTTCT TCACGGCACT AAGAACTATT TCACATCAGT TGCCCATCCA AACTTGTTTA TTGCCACAAA TGGGTGTGCT TGGCAGGGGG GCCACCCTCT ATCACTGACT TTCAGATACT GGAAAACCAG GGAGTCTCAC TITGTCTCACT TGTGCAGTGT TGACAGTTCA TATGTACCAT GTACATGAAG CTTTACTGTT AGTCMTTTGC TGAGCATGTA CTGAGCCTTG TAATTCTAAA TGAATGTTTA AAGAGTGGAA CCAACACTAA CATATAATGT TGYI7ATTTAA AGAACACCCT ATA'rrrrGCA CATTITTAATT ATrATTCTTC ATAACAATTT TAGGAGGACC AGAGCTACTG ACTATGGCTA TCTACCCATA TTACAGATGG GCAAATTAAG GCATAAGAAA ACTAAGAAAT ATGCACAATA CAAGAAGCCA CAGACCTAGG ATTTCATGAT TTCATTI'CAA CTGTTTGCCT TCTGCT[TTA GAACTCTTAA TCAAATAGCA TAAGTTTCTG GGACCTCAGT TTTATCATTT TCAAAATGGA CCTAAGCCTT CCTGCCGCAA CAGTTTTTA TGCTAATCAG GGAGGTCATT TTGGTAAAAT GCCOAGCCTC AAGATGAAGG CAAAGCACGA AATGTTAT TTTAATTATT ATTTATATAT ATATATTTAA GATAATTATA ATATACTATA TT[ATGGGAA CCCCT~rCATC CTCTGAGTGT CCTCCACAAT AGCAGACAGT GTJTTTCTGGG ATAAGTAAGT TTGATTTCAT TAATACAGGG CAAGTTGTGC TTATCCCATA GCCAGGAAAC TCTGCATTCT AGTACTTGGG AGACCTGTAA AATGTACATT AATTACCTTG AGCCAGTAAT TGGTCCGATC TTTGACTCTT TTGCCATTAA GCATTCTTGT TTCATTCAAT TCCACCTGCA ATCAAGTCCT ACAAGCTAAA ATTAGATGAA ACAACCATAG ACCACTOTTA TCAAAAC1TI' C1TTCTGGA ATGTAATCAA TGTTTCTTCT AATTGTGATC AGACCATAAT G31TACATTAT TATCAACAAT AGTGAYJ7GAT AGAGTGTTAT CAGTCATAAC TAAATAAAGC 'I1TGCAAGTGA GGGAGTCA1T TCATTFGGCGT TTGAGTCAGC AAAGAAGTCA AG AGCTGCCAGC CAGAGAGGGA GTCATrTCAT TGGCGTTTGA GTCAGCAAAG AAGTCAAGAT GGCCAAAGTT CCAGACATGT TTGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGAAATCC TTCTATCATG TAAGCTATGG CCCACTCCAT GAAGGCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCTCTAA AACATCCAAG c'FrAccTrCA AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGGTTCT GAAGAAGAGA CGGTTGAGTT TAAGCCAATC CATCACTGAT GATGACCTGG AGGCCATCGC CAATGACTCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CC1TTTAGCT TCCTGAGCAA TGTGAAATAC AACTTTATGA GGATCATCAA ATACGAA1TC ATCCTGAATG ACGCCCTCAA TCAAAGTATA ATTCGAGCCA ATGATCAGTA CCTCACGGCT GCTGCATTAC ATAATCTGGA TGAAGCAGTG AAATTTGACA TGGGTGCTTA TAAGTCATCA AAGGATGATG CTAAAATTAC CGTGAYFCTA AGAATCTCAA AAACTCAATT GTATGTGACT GCCCAAGATG AAGACCAACC AGTGCTGCTG AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAACCT CCTCTTCTTC TGGGAAACTC ACGGCACTAA GAACTATTTC ACATCAGTTG CCCATCCAAA CT-FGTTTATT GCCACAAAGC AAGACTACTG GGTGTGCTTG GCAGGGGGGC CACCCTCTAT CACTGACTTT CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCTCACTT GTCTCACT7G TGCAGTGT~rG ACAGTTCATA TGTACCATGT ACATGAAGAA GCTAAATCCT TTACTGTTAG TCATTrGCTG AGCATGTACT GAGCCTTGTA ATTCTAAATG AATGTrACA CTCTTTGTAA GAGTGGAACC AACACTAACA TATAATGTTG TI'ATTTAAAG AACACCCTAT AT-rTTGCATA GTACCAATCA TITrTAATTAT TATTCTTCAT AACAATTTTA GGAGGACCAG AGCTACTGAC TATGGCTACC AAAAAGACTC TACCCATATT ACAGATGGGC AAAT7AAGGC ATAAGAAAAC TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTCATGAT CATTTCAACT GTTGCCYT~c TGCTTTTAAG T-rGCTGATGA ACTCTTAATC AAATAGCATA AGT-TCTGGG ACCTCAGTTT TATCATTC AAAATGGAGG GAATAATACC TAAGCCTTCC TGCCGCAACA GT1TTT-ATG CTAATCAGGG AGGTCATT GGTAAAATAC YTCTCGAAGC CGAGCCTCAA GATGAAGGCA AAGCACGAAA TGTUATT'FIT TAATTA'rrAT TTATATATGT ATTrATAAAT ATATTTrAAGA TAATrATAAT ATACTATATT TATGGGAACC CCT7CATCCT CTGAGTGTGA CCAGGCATCC TCCACAATAG CAGACAGTGT TITCTGGGAT AAGTAAGTTT GATTTCA'rrA ATACAGGOCA TT17GGTCCA AGTTGTGCYIT ATCCCATAGC CAGGAAACTC TGCATTCTAG TACTTGGGAG ACCTGTAATC ATATAATAAA TGTACATTAA TI1ACCUGAG CCAGTAATTG GTCCGATCTT TGACTC=rr GCCATUAAAC TI1ACCTGGGC AT-rCTGrT CATTCAATTC CACCTGCAAT 114 CAAGTCCTAC AAGCTAAAAT TAGATGAACT CAACTTTGAC AACCATGAGA CCACTGT-fAT CAAAACTTTC TTTTCTGGAA TGTAATCAAT GTrCTTCTA GGUTCTAAAA ATTGTGATCA GACCATAATG TTACAY17ATT ATCAACAATA GTGATTGATA GAGTGTTATC AGTCATAACT AAATAAAGCT TGCAACAAAA TTCTCTG GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC CTGGCCCTGT GGGGACATGA ACTGTGTTTG CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG GCCAGATACA GCTGTCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGTT[ CCCCAGACCC TCGGGCCGAG CTGGACAGCA CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA GCTGGCTGCA CAGCTGAGGG ACAAATTCCC AGCTGACGGG GACCACAACC TGGATTCCCT GCCCACCCTG GCCATGAGTG CGGGGGCACT GGOAGCTCTA CAGCTCCCAG GTGTGCTGAC AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCACGTG CAGTGGCTGC GCCGGGCAGG TGGCTCTTCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GGGCCGCCCA CGCCATCCTG GGGGGGCTGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTGCT GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CCTTCCAAAG CCAGATCTTA TTTATTJ7ATT TATTTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCATITATCT CCCCCTAGTT AGAGACAGTC CT!TCCGTGAG GCCTGGGGGA CATCTGTGCC TTAUTTATAC TTATTTATTT CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG GGACTGGGGT CCCGGATJTCT TGGGTCTCCA AGAAGTCTGT CCACAGACTT CTGCCCTGGC TCTITCCCCAT CTAGGCCTGG GCAGGAACAT ATAUTATTTA TTTAAGCAAT TACTTTTCAT GTI7GGGGTGG GGACGGAGGG GAAAGGGAAG CCTGGGTTrT TGTACAAAAA TGTGAGAAAC CTTTGTGAGA CAGAGAACAG GGAAUTAAAT GTGTCATACA TATCC CAGCTGCGGC ATCCTCTGTC TCAGAGTCTT GGTGTCTCTG TTCCTFFCCC CTCGGGGTCT CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CT-FCCTCCCG CTCTCTGATC TCTGACTCCC AGAACCTCTC CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TCTTTGCTTC TCTGGTGTGT CTCTCTGGCT GCCTCCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT CAGTCTGTCC TTCACTCTGT GTGTGTGTGT GTCTCTCTCT CTCTCTCTCC T-FCCCTTCCA CTCCCTCTTC CTCCTGCCTC CACCTCTCCA GGCCCCTGTC TTGTCCCTCC GTCCGGCCTT TCTCTGCC11T TCCGTCCTCC TGCCTCCCCA TCTCTCTCTG CTAGTCCTGT CCAGCCGGAC CCCCACCCAC AGTCGGGCCC CAGCGCUTGA GCCTGAGTGT CTGCTCCGGC CCGTGGAGGT GGAGGGAGGG GACGCCAATG ACCTCACCAG CCCCTCTCCG ACCACCCCCC CC1TrrCCCTT TTCAACTrr CCAAC1TITC CTTrCCGTGCC CTCCTCCGAG CGCGGCGGCG TGAGCCCTGC AAGGCAGCCG CTCCGTCTGA ATGGAAAAGG CAGOCAGOGA GGGTGAGTCA GGATGTGTCA GGCCGGCCCT CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCAGGCCCCC TATATAACCC CCCAGGCGTC CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC ATGCCTCCCC TCCCCAGCCG CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGTT AAAGGCCCCC GGCTCCCTGC CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGTTG GTTCATGGGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT GGGAGCAGAC CCCGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG AGCAGC1TCG GAGACAGGAG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC GGATGGAGGC AGCCAATCAG AGGCGCCOCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGAT'TCCGG CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGAAAGCG GGGAGAGCCG GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGGGC TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGATT GGCTGGCGGG TGGCCGGGTG GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCGGGCC ATGGCTCTGC CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG GCTCTGCCG CCCACCCGGC GGGCTCCTGG GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCTGGGC T1T-GGCTCC TIFCCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG GTTCTGGCCT GTGCCTCCCC CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG GCGGACGGGA GACGCCCGGG CCGCGTCTGC TCCGACGGGC GGGGCAGCCA GAGCCAGGGA GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGCCCGCGG GCGTTCCACC CTGGGACTTA AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG CCCCAGACCC TCCTCCCCGA GACCCAGGAG TCCAGACCCC AGGCCTTCCT CCCTCAGACC TAGGAGTCCA GGCCCCCAGC CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGT7 CCTCCTCCCT CAGACCCGGG AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCCTrATC CTGCCCCCAG GTGTTTrGCCG CCTGGTCCTG GTCGTGCTGA GCCTGTGGCC AGATACAGCT GTCGCCCCTG GGCCACCACC TGGCCCCCCT CGAG1TITCCC CAGACCCTCG GGCCGAGCTG GACAGCACCG TGCTCCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT GOCTOCACAG CTGGTAGGAG AGACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG GAGTCTGCGG GCAGCCACTT GGAGGGGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG GAAGAGTTGG GGGCCTGGCG TGGGGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC TCACAGCTTT T-fTCCCTGCC AGAGGGACAA A'17CCCAGCT GACGGGGACC ACAACCTGGA TTCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC ACTGGTCGGG TGTTCTCTGA TGTCCCGGCT CTATCCCCAG

CTCCCAGGTG

GGGCAGGTGG

GCTGCGCCGG

CCAAAATCCT

CCCTGACACC

ACAGTCCTGC

CCCCCAAATC

TGCTGACAAG GCTGCGAGCG GACCTACTGT CTCTTCCCTG AAGACCCTGG AGCCCGAGCT CTGCAGCTCC TGGTATGTCC TGGCCCCAAG GTGGCCTGAG TCCTTGAAGC CTGAGACCCC CTAACAGCCC GCTCTGAGAC CCTGACACCG TCTGAGACCC TGACCCTGCA GTCCCAAGAT CTGCCCAGAA ACTTCAAATTF CTCACCCAAG 115

CCTACCTGCG

GGGCACCCTG

ACCTGACACC

AGACCCGAGT

TAACAGCCCC

CCTGTGGCCC

ACCCTGAGAC

GCACGTGCAG

CAGGCCCGAC

CCAGACCCCC

GCAACAGCCC

GCTCTGAGAC

TGAGACCCTG

TCCATCATCC

TGGCTGCGCC

TGGACCGGCT

ACCCCTGGCC

CGCTCTGAGA

CCTGACCCTA

AGGCCCTAGA

ATGACCTCAA

AGTCCCCAGA TCCCAGCCCC TAAGACCCAA GACCCCATCC TGAAGCCCAA AGCCTlGAGA ATTrCAAATCC TCACCTCAAG ACTTGGAGAC CCTGGCCCCA TGACATTGAA AACCATGGAC CTGGCCAGGC GTGGTGGCTC ACGCCTGTAA TCCCAGCACT TTGGGAGGCC GAGGCAAGTG GATCACCTGA GGTCGGGAGT TCAAGACCAG CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC AAAATTAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CTACTTGGGA GGCTGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCATTACAC TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAAA AAGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAGGCCCC AGCCCTGAGA TCCTGACATC TTAAAGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA AGCCAGCCTT GGGACCCTGG

CTGTACAAAC

AAAACCCTGA

CCAAAGCCCT

ATTCCAACTT

CTCTAAGACT

GTAAAACCCC

AAGGACCTCT

TTATTATTAT

TCGGCTTGCT

CTT1CAGGTGC

CCCAGGCTGG

AGGCGTGACG

ATTCCAGCCC

TCCACAGACT

GAACCCCACA

GCAGCCCCGA

TCACCTCTCT

CCCGCTGGCG

CTGACACTTG

ACCACCGTCC

ATCCCCCCGC

ATTTATACTTr

ACTGGGGTCC

AGGCCTGGGC

CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT ATGTCTCACT CCCAACATCG CACCTCAGAT CCTGAGCCTG CGCCTGTACG ACTCCAAGAC CCTCACTTCC AAAGCCAGGC GAGACCAGAA GACTTCAAAC CCTGGTTCTT GjGGCCTAACT CCAAAGACCC TGGATCTCAA CTAGCTCTGA GACTCCAGCC CTCACCCATG AGTTCCTGAA CTTGAACCCA GAGACCCCAT TCAGCCTTGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT AGCTCTGGTG GGGAGCAGTG GCTCACTCCT GTAATCCCAA GGCAGGGGAG GCCAAGGCAG TGAGGCCATG AGTTrGAGAC AGCCTGGGCA GCATAGCAAG ACTCTGTTTC TTAATTATTA TATTTrTGG AGACAGAGTC

GGAACCTCCG

ACACTGCCAC

TCACAAACTC

CCGCGCCTGG

CGGCGACTCT

TCACCCCCAA

GCCTGAAGAG

TTCAGCTGCA

CCTCCTGGGC

ACCCGGATAA

CTGAGCTCAG

CTTCTTFAATT

AACAGTCCCA

CCCCCACACT

CTCCCGGCCT

GCTCCACAGC

TCGCGCTCTG

TCAAGCGAIT

TTTTTFTTGTA

GCCATCCGCC

GTTCTA-ACAG

GGCCCGATCC

CAGCTCTGGA

AAACACTTCA

ACCCCTGCCC

GCCTGGCCCT

GGGCATCAGG

CTGCTGCTGA

TATTTA1TFTA

AGACAGTCCT

rGGGAGGCAG CCTCTCCCCA CAGATGTCCC CCCCCCTCCT CAGCCTGGGG ACTGGGCCGT GAGGGGACTG YITCCAAAGCC AGATCTTATT CATTATCTCC CCCTAGTTAG ATTTATTTCA GGAGCAGGGG CGGATFTCTTG GGTCTCCAAG AAGTCTGTCC AGGAACATAT ATTATTTATT TAAGCAATTA TTFGCCCAGGC TAGAGTGCAA TGGTGCCATT CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA TTTTAGTAGA CACAGGGTT-r CACCGTGTTG CGCCTCGGCC TCCCAAAGCG CTGGGATAAC CAGCGACAAC AACAAAAACC CAGCTCTGAG CTCACCTAGA ACCGAGATGC CAGCCCTGAC AGCCCGTCCT GACTCCAGCC TCCATT-FTCG CCCCACGCGC CACAGTCCCC CTGTGAATAT TGCACCCCCG CTGCACCCCC TACCTGTGAC GCCCCAGCCA CCCCCGGACC CGCCGGCGCC GCCGCCCACG CCATCCTGGG GGGGCTGCAC AGACTCGGCT GTGACCCGGG GCCCAAAGCC TrFTCAGTACT GGGGGCGAAA CAGCCAGGTG TCCGTGAGGC CTGGGGGGCA TCTGTGCCTT GTGGACTCCT GGGTCCCCGA GGAGGAGGGG ACAGACT[CT GCCCTGGCTC TTCCCCATCT CTTYITCATGT TGGGGTGGGG ACGGAGGGGA TrGTGAGACA GAGAACAGGG AATTAAATGT GGGCTGGATG CTTGGGTAAC TGGGGCAGGG TGGGCGGGGC AGCGACTGGG AGATGGGTCG CCTGGGGCCC CGCACTGCAT AGGGCCGTTT TGGAGTGCAG TGAGGCAATC TAAGGTCACT AGCCTCCCGA TTAGCTGGGA TCACAGGTGT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG GCCTCGGCCT CCCAAAGTGC TOGGATTACA TAr-FrAATGG AAGGTTCCAC AAGTCACCCT AGATGGTTCA TTATGGCTGT GT[CACCATA AGCAACATGG TGCATCTGTG GATAGAACGC TAAGGAGAGA GGCTI7GCTTG GGATATAGAA TAATCCTGGC ACTTTGGGAG GACGAAGCGA GACATGGCAA AACCCTGTCT CAAAAAAGAA AAGGGAAGCC TGGGTTTTTG TACAAAAATG TGAGAAACCT GTCATACATA TCCACTTGAG GGCGATTTGT CTGAGAGCTG CAGGTGGAGG GGAGACCTCC GTCACCCAGA CAGCTCTGTG GTTTGTrT[T TGAGATGGAG

GCAACCTCCA

GCACCACCAT

CCAGGCTGGT

GGTGTGAGCC

GTGATCAACA

GCAAACTGGA

CACCCAGCCG

AGATATCCTG

CCTCCCGGGT

GCCCAGCTAA

TTCGAACTCC

ACCACACCTG

GTACCCGTAT

AACAATCTAG

CCCGGAGCAG

ACATTGGCCA

ATTCAGGTGG

GAGGCAGGGT

TCTCGCTCTG

TCAAGCAATr

TTATTTATTT

TGACCTCAGG

ACCCATAGGT

GGGACAAAGC

ATATCCAACA

GGACTGTCAT

GGCATGGTGG

AGTTTGAGAC

AGGTCCCGAG

CTGAGCCTTG

TTGCCTAGGC

CTCCTGCCTC

CTTTTGTATT

TGATCCTCCT

C~rCAATAAA

TGCAAGGTCA

GTGAGGGTTA

TCAGGGAGGC

CTCACGCCTG

CGGCCTGCGA GTGGATCACT GAAGTCCAAG AGAATGATGT CCTGACATGA AACAGCAGGC TACAAAACCA CTGCATGCTG TGATCCCAAT TTTGTGTTTT TCTTTrCTATA TATGGAT-rAA AACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTTGACAA CAGGTCAAAG GAGAGAGGTG GGATTGTGGG TGACT1TAA TGTGTATGAT TGTCTGTAYJ7 TCTGCCATGA CTGTGTAT-rT TGCATGACAC ATT-FTAAAAA TAATAAACAC TATT-rTTAGA ATCAGCCTCC TCCTCTCCAA AAATAAGCCC TCAGGAGGGG ACAAAGTTGA CCGCTGATTG GGCTGTGCAC-3- (SEQ. ID NO:3004)

TGACTGTCTC

TTACAGAATT

ATAACAGAAT

AGCCTGTCAG

Human Adenosine A, Receptor Nucleic Acid and Antisense Oligonucleotide Fragments CCATCTCAGC UTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCT7CTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTr CCACACCTGC CTCATGGT-FG CCTGTCCGGT CCTCATCCTC CCATCCTGGC CCTGCTGGCA A1TGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT CCCCTATGT TrGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCCCGTGAT CAAGTGCGAG TCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA GTGGGTGCTG CCCCCGCYJ7C TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AGTCGCTGGC CCTCATCCTC TI7CCTCTrTG CCCTCAGCTG GCTGCCYTrTG CACATCCTCA

ACCCAGAGCT

GGTACAAGAT

GGTGGGACTG

AGCATGGGGG

ACTfTCTGT

CCGCAAGCAG

AAGATCGCCA

ACTGCATCAC

CCTCT-FCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTOCCA TCTTCCTCAC G3CACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTrC CGCATCCAGA AGTTrCCGCGT CACCTrCCTT AAGAMrIGGA 116 ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC GGTGAGGAAG GG1TTTAACCT CACTGGAAGG AATCCCTGGA

GGGGCACTTG

AGCGCTGCGG

CGCGGCCCGG

ATGGTGCTTG

CCATCTCAGC

CGTGCTGGTG

CTGGCGGTGG

AGACCTACTT

CCTGCTGGCA

CCCCGGAGGG

Y7GGCTGGAA

CAAGTGCGAG

CCCCCGCT-rC

AGGTGTCGGC

CCTCATCCTC

CCGTCCTGCC

ACCCCATTGT

CCGCTGCCAG

TCCGCTCCCA

CCCTGAGCCT

GTGGTCCCTC

CCTACGGAGG

AGTCCAGCGC

AAGGTGCTfG

ACCAAGCTTA

CTGTTCTGTA

GACAGAACAG

CGGGAGCCGG

AGCTCTGTTC

CCTCGTGCCC

TTTCCAGGCC

ATCTGGGCGG

CTGATGTGGC

CCACACCTGC

ATTGCTGTGG

TCAGGCAGCC

AGGACTATGA

CCTGGAACTT

CT-FGGTGCCC

GCCTACATCG

TGAAGGTGAA

CGTGGGTGCC

CTCATGGTTG

ACCGCTACCT

GGGAGCTCTG

GCTGCCGCGC

TGGGCACTGC

GTCTGCTGAT

GCATCGAGGT

CCAGGCGCTG

CTGGTCATCC

CCTGTCCGGT

CCGGGTCAAG

AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG CCAGC1TITGG TGACCTTGGG CCGGGCTGGG G~rGTCCAGA GCCCAGCCCA GCCCTACGCG CTCTGGGACC CCTGCCGGCC AGCAGGCAGG GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGGGATGCCA CCTTCTGCTT CATCGTGTCG CCCTCGCCAT CCTCATCAAC AITGGGCCAC CCTCATCCTC ACCCAGAGCT CCATCCTGGC ATCCCTCTCC GGTACAAGAT GGTGGTGACC TCTCCTTCGT GGTGGGACTG ACCCCTATGT AGCCAACGGC AGCATGGGGG AGCCCGTGAT CGGCGGTGGC CATAGCCGGC TGCTGGATCC CAATCTGAGT GCGGTGGAGC GGGCCTGGGC TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTFTGT GTGGGTGCTG TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC ACAAGCCCAG CATCC'rrACC TACATTGCCA TCTTCCTCAC GCACGGCAAC CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC GCCCCAGCTG GGCTGT-fGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA

AGTCGCTGGC

CCTCTTCTGC

TCGGCCATGA

ATGACCATTT

GACCCCGCCT

CCAGGGGTCT

CCCACAGAGT

GGGCAAGGGT

GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC 'ITCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG GGCYI'CTGCG GTGAGGCAGG GGAGTCTGCT AGGAGAGGAG AGCATCTGCT CTGAGACGGA GGAGAGACTG GCCAGAGGCA GAGGACTCTG GACCCCAGGC CATACCAGGT YTGTACGTGG GAGAGGCAGA AAGGGTAGGT ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG CACTGGCCCC CGTTGCCGGG CCTGGACTGT GAGGAGAACA CTAGACATGC CAACTCGGGA

GCTAAGGGGC

GCTAGGGTGC

TCAGTAATCA

GTGCTGGCCT

AGCCTGGAGT

CCTAGGjTGAC TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG TGGAAGGAGA GAGGTTGAGG ATGCACTGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA 1TTTCTGATGA TTTGCTGGAG TGCTGGCTCC CAAACAGCCA CGAGGTGGTA GCTCTGAGCC GTAATTACCT GTCATCTGGG CCACCAGCTC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTFFTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TCTGGGGAAG GACCAACCCA TGCCCTGCCA

TTGCAGGTGT

AGCCTGGAGC

TGGAGCCCCT

CCTGGAGCCC

AACTCCAGGA

CCATGTGACT

TCTTGAAGAG

TTGGGTTGTT

TCTCGCTGTG

GAGCTTACCG

GGGGGCACTT

CGTGCCCC1TT

CCAGGCCGCC

TGGGCGGTGA

ATGTGGCCGT

CACCTGCCTC

GCTGTGGACC

CGGTGGCCAT

TCTGAGTGCG

GAGAAGGTCA

TCATGGTCCT

CTCCGGCGAC

CTCrTGCCC

AGCCCAGCAT

TGCCTTCCGC

GCACCTCCCA

CCCACATCCA

CAGCTGGGCT

GTGTGGGAGO GCGAGGCGGG GGAGCCTGGA CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA AATAAAAAAC TGTGAACCCT CGCATTTGTG AGACAAAGGA AGGAAAATTT AAATCCTTAG GTrGTTGTTrG TTTGGTGTGT 17~TTTGTfTTT TTACCGGGAG CGACAGAGCC GCACGGCCGA GCCGGCCTTG GCTTCCCCAG GAATCCCTGG GGACAGAACA GTCAGGCAGC CGGGAGCTCI GGTGCCCGTC TGCTGATGTG CCCAGCCTGT TACATCGGCA TCGAGGTGCT CATCGCCCTG AGGTGAACCA GGCGCTGCGG GATGCCACCT GGGTGCCCTG GTCATCCCCC TCGCCATCCT ATGGTTGCCT GTCCGGTCCT CATCCTCACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT AGCCGGCTGC TGGATCCTCT CCTFCGTGGT GTGGAGCGGG CCTGGGCAGC CAACGGCAGC CCGGGGGTCT AGGACTTTAG GGATCTGGGA CCCTGTGYrG GGGGGCAAGG TGGGGGAGCC GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCGTCGGTTG ACCTJTCTGAA CATGAGTGTC ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC TTTTAATAAA AGAATCTGGA AGATAAATAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTTGTTTTTT TGTTTFTTMT TGAGATGGAG GTCGAGTCCC AGCCAGCTAC CATCCCTCTG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GCCAGCTTTG GTGACCTTGG GTGCT7GCCT GCCCGCCATG CCGCCCTCCA GTCTCTGTGC CCGGGAACGT TCTGCT~rCAT CGTGTCGCTG CATCAACATT GOCCACAGA CAGAGCTCCA TCCTGGCCCT ACAAGATGGT GGTGACCCCC GGGACTGACC CCTATGT'rrG ATGGGGGAGC CCGTGATCAA

TCTCAGCT[

GCTGGTGATC

GCGGTGGCTG

CCTACTTCCA

GCTGGCAATT

CGGAGGGCGG

GCTGGAACAA

GTGCGAGTTC

CCGCT'TCTCC

TGTCGGCCTC

CATCCTCTTC

TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT

TCAGCTGGCT

CCTI'ACCTAC

ATCCAGAAGT

TTGACGAGGA

GTGGGGTCTC

G17GGCTGGG GCCTrGCAC ATCCTCAACT GCATCACCCT CT-rCTGCCCG TCCTGCCACA ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TCCGCGTCAC CTFCC'rrAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCT-rCC GCTCCCACCG AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGAGTTAAC TACCCTACAC AGGTGTCTAG AGGCAACAGT G'1rCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA 117 GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TrGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA GAT GGA GGG CGG CAT GGC GGG G CGG GTC GCC GG GGC GGG CBC BGG C GGC GGG CBC GC GGC CTG G GGB GGG CGG C GBT 0GB GGG GG CTG GGC GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC ATGCCGCCCT CCATCTCAGC MTCCAGGCC GCCTACATCG

GCATCGAGGT

CCAGGCGCTG

CTGGTCATCC

CCTGTCCGGT

CCGGGTCAAG

TGCTGGATCC

GGGCCTGGGC

GGAGTACATG

CTGGAGGTCT

AGTACTATGG

GCTGCCTTTG

TACAFFGCCA

AGTTCCGCGT

GGATCTCCCA

AGAGCCTCCT

GCTAGCGGCT

CCAGC11TTGG

GTTGTCCAGA

CTCTGGGACC

GTGCCCAGCC

GCTCATCGCC

CGGGATGCCA

CCCTCGCCAT

CCTCATCCTC

ATCCCTCTCC

TCTCCTTCGT

AGCCAACGGC

GTCTACTTCA

TCTACCTAAT

GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGC!GG TGAAGGTGAA CGGGATGCCA CC'UCTGCTrF CATCGTC!TCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG UTCGAGAAGG TCATCAGCAT GTCTACTTCA ACTTCTTTGT GTGGGTGCTG, CCCCCGCTTFC TCCTCATGGT CCTCATCTAC TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC! CTCCTCCGGC GACCCGCAGA GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TrCCTCTTTG CCCTCAGCTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTUFC CGCATCCAGA CACCTTCCT[ AAGATTJTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC CTCCCTCTGT GAGGCTGGC!A GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG TGACCYITGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGC GC

GCCCAGCCCA

CCTGCCGGCC

TGTGCCCGCC

CTGGTCTCTG

CCT-FCTGCTT

CCTCATCAAC

ACCCAGAGCT

GGTACAAGAT

GGTGGGACTG

GCCCTACGCG CGCGGCCCGG AGCAGGCAGG ATGGTGCTTG

ATGCCGCCCT

TGCCCGGGAA

CATCGTGTCG

ATITGGGCCAC

CCATCCTGGC

GGTGGTGACC

ACCCCTATGT

CCATCTCAGC

CGTGCTGGTG,

CTGGCGGTGG

AGACCTACTT

CCTGCTGGCA

CCCCGGAGGG

AGCTCTGTTC CCTGGAACTT TGGGCACTGC CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT TTrTCCAGGCC GCCTACATCG GCATCGAGGT ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCACACCTGC CTCATGGTTG CCTGTCCGGT ATTGCTGTGG ACCGCTACCT CCGGGTCAAG CGGCGGTGGC! CATAGCCGGC TGCTGGATCC TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCATGGGGG AGCCCGTGAT ACTTCTTTGT GTGGGTGCTG CCGCAAGCAG CTCAACAAGA

CAAGTGCGAG

CCCCCGCTTC!

AGGTGTCGGC

TUCGAGAAGG

TCCTCATGGT

CTCCTCCGGC

GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTrG CACATCCTCA ACTGCATCAC CCTCTTrCTGC! CCGTCCTGCC ACAAGCCCAG TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CACCT-rCCTT AAGAITT7GGA ATGACCAT'IT CCGCTGCCAG CCTGCACCTC GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT GCCCTGC!AGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCC!AGCGC TTCAGGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA T-rTCTGATGA TTTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG, CCCTGAGC1TT GTAAYI7ACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCCATCTCTG CTGCTTrCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA

TCATCAGCAT

CCTCATCTAC

GACCCGCAGA

CCCTCAGCTG

CATCCTTACC

CGCATCCAGA

CCATTGACGA

TCCAGTGGGG

GGAGTACATG

CTGGAGGTCT

AGTACTATGG

GCTGCC'ITTG

TACATTGCCA

AGTTCCGC GT

GGATCTCCCA

TCTCAGTCCA

GGCTGTTGGC TGGGGGCATG TAACTACCCT ACACCTCTGG CTAGAGGCAA CAGTGTTCTG GGCAGGTCCT GGGGAGGCTG GTGAGGCAGG GGAGTCTGCT AGCATCTGCT CTGAGACGGA GCCAGAGGCA GCTAAGGGGC CATACCAGGT GCTAGGGTGC AAGGGTAGGT TCAGTAATCA GGTGCGGTAG GTGCTGGCCT TCCGGGGAGG AGCCTGGAGT CCTGGACTGT CCTAGGTGAC CAACTCGGGA GCArI7CTGCC CTGTAGGCGC! CCCTGGGGTG TGGGGGAAGG CCYI7GCTGTC GGAAGCTCTG TTGCAGGTGT TGCCCTGCCA AGCCTGGAGC!

GGTTFJTAGCAG

ATGTGAATCC

CCGGGGGTCT

CCC TGTGTTG

GCCCCTGTGT

CCGTCGGTTG

ATTGGGTGTG

TITUAATAAA

ATTCAAGCAG

TrrG'rrlTTr

GTCGAGTCCC

AGCTAGC!GGC

GCCAGCTTTG

GCTGCAGCAG

CTCAATACCC

AGGACTTrAG

GGGGGCAAGG

GGGAGGGCGA

ACCUTCTGAA

CCCTGGCTCC

AGAATCTGGA

GCAGAGGAGG

CTAGTATCTG

GGATCTGGGA

AGTACCCCCC

GCTGGG1TI7rT

TCTGGGGAAG,

TGAGAGCATG

CAGGGGCTTI'

GACCAACCCA

TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT AGATAAATAG TC'ITGAAGAG AGACAAAGGA AGGAAAAT

GGAGCCTGGA

GGGGAGGTGG

TCTGT-rGGAA CGCATrTGTG

AAATCCTTAG

1TTGT1T

GCACGGCCGA

GAATCCCTGG

CGGGAGCTCT

CCCAGCCTGT

AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGUTGTTG TITGGTGTGT TGTTTT= TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC AGCCAGCTAC CATC!CCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG TGCTGAAGG-C GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC GTGACCTTGG GTGC1TGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG 118 GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT

CATCGCCCTG

GATGCCACCT

TCGCCATCCT

CATCCTCACC

CCTCTCCGGT

CCT'TCGTGGT

GGGACTGACC CCTATGTTTG GCTGGAACAA ATGGGGGAGC CCGTGATCAA GTGCGAGTTC TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGiGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGG;AA GGAGCTG;AAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTFTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATrGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCAT7GTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTrCCT-rAAG ATTTFGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCrrCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TrAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG T[GAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA -3'(FRAG.NO:_3(SEQ.NO:3005) [2423)1 TI1TTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCYITAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GT-fGTTGTTG TTTGGTGTGT TJTTTTGTTTT T'FrGTTFT~ TG1TTTTTTT TGAGATGGAG TCTCGCTGTG TACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC GAATCCCTGG AGCTAGCGGC CGGGAGCTCT GCCAGCTTTrG AGCCAGCTAC CATCCCTCTG TGCTGAAGGC GTCGAGGTGT GTGACCTTGG GTGCTTGCCT CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC GATGCCACCT TCTGCTTCAT CGTGTCGCTG GGGGTGGCTG TCGCCATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CC11TCGTGGT GGGACTGACC CCTATGT'rrG GCTGGAACAA CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC TACTTCAACT TCT'ITGTGTG GGTGCTGCCC CCGCTTCTCC ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC ATCCTCAACT GCATCACCCT CTI1CTGCCCG TCCTGCCACA TCCTCACGCA CGGCAACTCG GCCATGAACC CCAT-FGTCTA CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GAGAGGCCTG ATGACTAGAC CCCGCCTFCC GCTCCCACCG TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC GAGCTTACCG GCCGGCC31TG GCTTCCCCAG GGGGGCACTT GGACAGAACA GTCAGGCAGC CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCAGGCCGCC TACATCGGCA TCGAGGTGCT TGGGCGGTGA AGGTGAACCA GGCGCTGCGG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC CACCTGCCTC ATGGTTGCCT GTCCGGTCCT GCTGTGGACC GCTACCTCCG GGTCAAGATC CGGTGGCCAT AGCCGGCTGC TGGATCCTCT TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC GAGAAGGTCA TCAGCATGGA GTACATGGTC TCATGGTCCT CATCTACCTG GAGGTCYFrCT CTCCGGCGAC CCGCAGAAGT ACTATGGGAA CTC1TFGCCC TCAGCTGGCT GCCTTfrGCAC AGCCCAGCAT CCTTACCTAC ATTGCCATCT TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC GCACCTCCCA TTGACGAGGA TCTCGCAGAA CCCACATCCA GTGGGGTCTC AGTCCAGTCC CAGCTGGGCT GT1TGGCTGGG GGCATGGGGG AGGAGTTAAC TACCCTACAC CTCTGGGCCC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGC'ITGTC TJTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA (FRAG. NO:_9(SEQ. ID NO: 2434) ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTrG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTflGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GT7GTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAAC'IT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGOCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC 17TCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACT[ CCACACCTGC CTCATGGYI7G CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGOGTCAAG ATCCCTCTCC GOTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACT[CA ACTTrCTTrGT GTGGGTGCTG CCCCCGCT-rC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGOC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC 119

CCTCATCCTC

CCGTCCTGCC

ACCCCATTGT

CCGCTGCCAG

TCCGCTCCCA

CCCTGAGCCT

GTGGTCCCTC

TJTCCTCTTTG CCCTCAGCTG GCTGCCTI'TG ACAAGCCCAG CATCC'ITACC TACATTGCCA CTATGCCTTC CGCATCCAGA AGTTCCGCGT CCTGCACCTC CCATTGACGA GGATCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GCCCCAGCTG GGCTGTTGGC TGGGGGCATG CACTAGGAGT TAACTACCCT ACACCTCTGG

CACATCCTCA

TCTTCCTCAC

CACCTTCCTT

GAAGAGAGGC

GTCCTCACAT

GGGGAGGCTC

GCCCTGCAGG

ACTGCATCAC

GCACGGCAAC

AAGATTTGGA

CTGATGACTA

GCCCGCTGTC

TGAAGAGATA

AGGCCTGGGA

CCTCTTFCTGC

TCGGCCATGA

ATGACCAYT

GACCCCGCCT

CCAGGGGTCT

CCCACAGAGT

GGGCAAGGGT

CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTIG GGCT17CTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GU-GGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA U-TCTGATGA rrTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGiGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTfCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCAT[FCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTFTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG ccTrGCTGiTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGrG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTrCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT (FRAG. NO: SEQ. ID NO: 2433) ATGCCGCCCT CCATCTCAGC T-TCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTfCTGCTT

CATCGTCTCG

ATTGGGCCAC

CCATCCTGGC

GGTGGTGACC

ACCCCTATGT

AGCCCGTGAT

GTGGGTGCTG

CTCAACAAGA

AGTCGCTGGC

CCTCTTCTGC

TCGGCCATGA

CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC CCTGCTGGCA A'I1TGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCC'FFCGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC CAAGTGCGAG TTICGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA CCCCCGCYFC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG CCTCATCCTC TTCCTC1TTTG CCCTCAGCTG GCTGCCY-ITG CACATCCTCA CCGTCCTGCC ACAAGCCCAG CATCCYFACC TACATTGCCA TCTTCCTCAC ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTJ7CCTT

CCTCATCAAC

ACCCAGAGCT

GGTACAAGAT

GGTGGGACTG

AGCATGGGGG

ACTTCTTTGT

CCGCAAGCAG

AAGATCGCCA

ACTGCATCAC

GCACGGCAAC

AAGATTTGGA

ATGACCATTr CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G-3' (FRAC. NO:.9)(SEQ. ID NO: 2432) 5'-CGCA3TrTGTG YTJ7AATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGG3GTTGTT G117GTTGTTG TTTGGTGTGT MTTTGT-1TT TTTGT-rT'rrT TGTTT"TT TGAGATGGAG TCTCGCTGTG TrACCGGGAG CGACAGAGCC

GCACGGCCGA

GAATCCCTGG

CGGGAGCTCT

CCCAGCCTGT

CATCGCCCTG

GATGCCACCT

TCGCCATCCT

CATCCTCACC

CCTCTCCGGT

CCTTrCGTGGT GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTFACCG GCCGGCCTTrG GCTTrCCCCAG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC GCCAGCTT-rG

GCCCGCCATG

GTCTCTGTGC

TCTGCTTCAT

CATCAACATT

CAGAGCTCCA

ACAAGATGGT

GGGACTGACC

GTGACCTTGG GTGCTTGCCT CGTGCCCCT[ GGTGCCCGTC TGCTGATGTG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC GGGCCACAGA CCTACUTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA TACTTCAACT TCTITTGTGTG GGTGCTGCCC ACCTAATCCG CAAGCAGCTC AACAAGAAGG

GTGCGAGTTC

CCGCrrCTCC

TGTCGGCCTC

GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC ATCCTCAACT GCATCACCCT CTrCTGCCCG TCCTGCCACA TCCTCACGCA CGGCAACTCG GCCATGAACC CCAITGTCTA CTTCCTrAAG ATTTGGAATG ACCATCCG CTGCCAGCCT GAGAGGCCTG ATGACTAGAC CCCGCCTrrCC GCTCCCACCG

GAGAAGGTCA

TCATGGTCCT

CTCCGGCGAC

CTC1TfGCCC

AGCCCAGCAT

TGCCTTCCGC

GCACCTCCCA

CCCACATCCA

TCAGCATGGA

CATCTACCTG

CCGCAGAAGT

TCAGCTGGCT

CCTTACCTAC

ATCCAGAAGT

TUGACGAGGA

GTGGGGTCTC

GTACATGGTC

GAGGTCTrCT

ACTATGGGAA

GCCTT-rGCAC

ATTGCCATCT

TCCGCGTCAC

TCTCCCAGAA

AGTCCAGTCC

TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTI7GGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC 120 TOCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTI'G GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGGA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA -3' (FRAG. NO:9-(SEQ. ID NO: 2422) 5'-ATGAGTGTCA GAAGTGTGAA GGGTGCCTC GGTGAGGAAG GGTTrTAACCT CACTGGAAGG

GGGGCACTTG

AGCGCTGCGG

CGCGGCCCGG

ATGGTGCTTG

CCATCTCAGC

CGTGCTGGTG

CTGGCGGTGG

AGACCTACTT

CCTGCTGGjCA

CCCCGGAGGG

'TGGCTGGAA

CAAGTGCGAG

CCCCCGCTTC

AGGTGTCGGC

CCTCATCCTC

CCGTCCTGCC

ACCCCATITGT

CCGCTGCCAG

TCCGCTCCCA

GACAGAACAG

CGGGAGCCGG

AGCTCTGTTC

CCTCGTGCCC

TTTCCAGGCC

ATCTGGGCGG

CTGATGTGGC

CCACACCTGC

ATTGCTGTGG

TCAGGCAGCC

AGGACTATGA

CCTGGAACTT

C'FUGGTGCCC

GCCTACATCG

TGAAGGTGAA

CGTGGGTGCC

CTCATGGTTG

ACCGCTACCT

Tf TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGAGCTCTG CCAGCTTTGG TGACCTTGGG CCGGGCTGGG GCTGCCGCGC GTJTGTCCAGA GCCCAGCCCA GCCCTACGCG TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC -TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CGGCGGTGGC CATAGCCGGC CAATCTGAGT GCGGTGGAGC TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTAC'ITCA ACTTCTTTFGT GTGGGTGCTG

TCCTCATGGT

CTCCTCCGGC

TTCCTCTTTG

ACAAGCCCAG

CTATGCCTTC

CCTGCACCTC

CCAGCCCACA

CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTFCTGC CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA CGCATCCAGA AGTJTCCGCGT CACCTTCCTI1 AAGATTTGGA ATGACCAT7T CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG CCCTGAGCCT GCCCCAGCTG GTGGTCCCTC CACTAGGAGT CCTACGGAGG GACCAGGTGT AGTCCAGCGC TTCAGGGCTG AAGGTGCTfG GGCT7CTGCG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GAGGACTCTG GACCCCAGGC TFGTACGTGG GAGAGOCAGA ACGCCCTGGG GAGTGAGCTT CTCC'f7CTTG CCCTGAGCTT CACTGGCCCC CGTTGCCGGG GAGGAGAACA CTAGACATGC CTGTAAGGAC TCAGTGTTGA AGTACCCCCC TGAGAGCATG

GCCAGAGGCA

CATACCAGGT

AAGGGTAGGT

GGTGCGGTAG

]TCCGGGGAGG

CCTGGACTGT

CAACTCGGGA

GCTAAGGGGC

GCTAGGGTGC

TCAGTAATCA

GTGCTGGCCT

AGCCTGGAGT

CCTAGGTGAC

GCATITCTGCC

AGGAATCAAG GAGCCTCCGT TCCCACCTCT CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA T-1TCTGATGA TTITGCTGGAG TGCTGGCTCC CAAACAGCCA CGAGGTGGTA GCTCTGAGCC GTAATTACCT GTCATCTGGG CCACCAGCTC CCCATCTCTG CTGCTTCTGG GCCTGATGGA TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAGGCGC CCCTGGGGTG GGITrTAGCAG GCTGCAGCAG GCAGAGGAGG TGGGGGAAGG CCT-7GCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT (FRAG. NO:_ (SEQ.

CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT ID NO: 2421) GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTI7CTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACT-r CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGOAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG CCCCTATGT 'TGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCYrC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TF7CCTCT-rTG CCCTCAGCTG GCTGCCT~rTG CACATCCTCA ACTGCATCAC CCTC1TCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCUTC CGCATCCAGA AGTTCCGCGT CACCTrCCrr AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATI7GACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G (FRAG NO: (SEQ. ID NO: 2420) GGA GGG CGG CAT GGC GGG-3' (FRAG. NO: 1657) (SEQ ID NO:2412) CGG GTC GCC GG-3' (FRAG. NO: 1658) (SEQ ID NO:2413) GGG CBC BGG C-3' (FRAG. NO: 1659) (SEQ ID NO:24 14) 5'-GGC GGG CBC-3' (FRAG. NO: 1660) (SEQ ID NO:2415) GGC CTG G-3' (FRAG. NO: 1661) (SEQ ID NO:2416) 121 GGG COG C-3' (FRAG. NO: 1662) (SEQ ID NO:2417) GOB GGG-3' (FRAG. NO: 1663) (SEQ ID NO:2418) CTO GGC-3' (FRAG. NO: 1664) (SEQ ID NO:2419) GOC CG GAA AG TGA OAT OGA GOG CGG CAT GGC GO CAC AGO CTG OGC-3' (FRAG.1) (SEQ. InD NO: 11) 5'-C GG GTG GAA AOC TGA OAT OGA 000 COG CAT GOC 000 CAC AGO CTG, GGC-3(FRAG 2) (SEQ..tD NO: 12) CTO OAA AGC TOA OAT OGA 000 COO CAT GOC 000 CAC AGO CTO GGG-3'(FRAG 3)(SEQ.ID NO: 13) GTG OAA AOC TOA OAT OGA 000 COG CAT GOC 000 GAG AGO CTG OGC-3' (FRAG 4)(SEQ. ID NO:14) GTG OAA AGG TOA OAT OGA 000 COG CAT GOC 000 GAG AGO CGO GOC-3' (FRAG 5) (SEQ. ID NO: OAA AGG TOA OAT OGA 000 COG CAT GOC 000 GAG AGO CTO OG-3' (FRAG 6) (SEQ. ID NO: 16) 5'-TO GAA AGG TGA OAT OGA 000 COG CAT GG 000 GAG AGO CTG GC-3' (FRAG 7) (SEQ. ID NO: 17) GAA AG TOA OAT OGA 000 COG CAT GOC 000 GAG AGO GTG GG-3- (FRAG 8) (SEQ. ID NO: 18) AGC TGA OAT OGA 000 COG CAT GG 000 GAG AGO CG GGG-3' (FRAG 9) (SEQ. ID NO: 19) AOC TGA OAT OGA 000 COO CAT GOC 000 GAG AGO CG GGC-3' (FRAG 10) (SEQ. ID NO: AGG TGA OAT OGA 000 COG CAT GOC 000 GAG AGO, CTG GGG-3- (FRAG 11) (SEQ. ID NO: 21) 5'-AGG TGA OAT OGA 000 COG CAT GOC 000 GAG AGO CG GOC-3' (FRAG 12) (SEQ. ID NO: 22) TGA OAT OGA 000 COG CAT GOC 000 GAG AGO CG GGG-3' (FRAG 13) (SEQ. ID NO: 23) TGA OAT OGA 000 COG CAT GG 000 GAG AGO GTG GGG-3' (FRAG 14) (SEQ. ID NO: 24) OAT OGA 000 COO CAT GG 000 GAG AGO CG OOC-3' (FRAG 15) (SEQ. ID NO: OAT OGA 000 COO CAT GG 000 GAG AGO CG GOC-3' (FRAG 16) (SEQ. ID NO: 26) 5'-A OAT OGA 000 COO CAT GOC 000 GAG AGO CTG OG-3' (FRAG 17) (SEQ. ID NO: 27) OGA 000 COG CAT GOC 000 GAG AGO CG GGG-3' (FRAG 18) (SEQ. ID NO: 28) OGA 000 COO CAT GOC 000 GAG AGO GTG GGC-3- (FRAG 19) (SEQ. ID NO: 29) OGA 000 COO CAT GG 000 GAG AGO GTG GGC-3' (FRAG 20) (SEQ. ID NO: 000 COO CAT GG 000 GAG AGO GTG GGC-3' (FRAG 21) (SEQ. ID NO: 31) 5'-GA 000 COO CAT GOC 000 GAG AGO GTG OGC-3' (FRAG 22) (SEQ. ID NO: 32) 000 COG CAT GG 000 GAG AGO CTG GGC-3' (FRAG 23) (SEQ. ID NO: 33) 5'-000 COG CAT GG 000 GAG AGO CG GGG-3' (FRAG, 24) (SEQ. ID NO: 34) COO CAT GOC 000 GAG AGO GTG OGC-3' (FRAG 25) (SEQ. ID NO: COO CAT GG 000 GAG AGG CTG GG-3- (FRAG 26) (SEQ. ID NO: 36) 5'-COO CAT GG 000 GAG AGO CG GGC-3' (FRAG 27) (SEQ. ID NO: 37) CAT GG 000 GAG AGO GTG GGC-3' (FRAG, 28) (SEQ. ID NO: 38) CAT GOC 000 GAG AGO CTO OOC-3' (FRAG 29) (SEQ. ID NO: 39) GG 000 GAG AGO GTG GG-3- (FRAG 30) (SEQ. ID NO: GOC 000 GAG AGO GTG OG-3' (FRAG 31) (SEQ. ID NO: 41) 5'-T GOC 000 GAG AGO CG GG-3' (FRAG 32) (SEQ. ID NO: 42) 000 GAG AGO CTO OG-3' (FRAG 33) (SEQ. ID NO: 43) 000 GAG AGO CG OOC-3' (FRAG 34) (SEQ. ID NO: 44) 000 GAG AGO GTG GOC-3' (FRAG 35) (SEQ. ID NO: 5'-000 GAG AGO CG GGG-3' (FRAG 36) (SEQ. ID NO: 46) 5'-00 GAG AGO CG OOC-3' (FRAG 37) (SEQ. ID NO: 47) GAG AGO CG OG-3' (FRAG 38) (SEQ. ID NO: 48) AGO CTG GG-3' (FRAG 39) (SEQ. ID NO: 49) AGO GTG OG-3' (FRAG 40) (SEQ. ID NO: AGO GTG OOC-3' (FRAG 41) (SEQ. ID NO: 51) 5 '-AGO CG GGC-3' (FRAG 42) (SEQ. ID NO: 52) GG CTO OAA AOC! TOA OAT OGA 000 COG CAT GOC 000 CAG AGO CG GGC-3(FRAG 43)(SEQ.ID NO:53) GOC CG OAA AGC TOA OAT OGA 000 COG CAT OOC 000 CAC AGO GTG 00-3' (FRAG 44)(SEQ.ID NO:54) GG CTO OAA AG TOA OAT OGA 000 COG CAT GOC 000 CAG AGO CG 0-3' (iRAG 45)(SEQ.IID GOC CG OAA AGC TGA OAT OGA 000 COG CAT GOC 000 GAG AGO GTG (FRAG 46)(SEQ.t]D NO:56) 5'-GOC GOC CTO GAA AGC TGA OAT OGA 000 COO CAT GOC 000 GAG AGO GT-3' (FRAG 47)(SEQ.ID NO:57) GG CTO OAA AG TGA OAT OGA 000 COO CAT OOC 000 GAG AOG C-3- (FRAG 48)(SEQ. ID NO:58) GOC CTO GAA AGC TOA OAT OGA 000 COG CAT GOC 000 GAG AGO (FRAG 49) (SEQ. ID NO: 59) GOC CTO OAA AOC TOA OAT OGA 000 COG CAT GOC 000 GAG AG-3' (FRAG 50) (SEQ. ID NO: GOC CG OAA AG TOA OAT OGA 000 COG CAT GOC 000 GAG A-3'(FRAG 5 I) (SEQ. ID NO: 61) 5'-GOC GOC CG OAA AGC TGA OAT OGA 000 COO CAT GOC 000 CAC-3' (FRAG 52) (SEQ. ID NO: 62) GOC CTG GAA AGC! TOA OAT OGA 000 COG CAT GOC 000 CA-3'(FRAG 53) (SEQ. ID NO: 63) GOC CTO OAA AOC TGA OAT OOA 000 COG CAT GOC 000 C-3- (FRAG 54) (SEQ. ID NO: 64) GOC CGO OAA AOC TOA OAT OGA 000 COO CAT GOC 000 (FRAG 55) (SEQ. ID NO: OGC CTG OAA AGC TOA OAT OGA 000 COO CAT GOC 00-3' (FRAG 56) (SEQ. tD NO: 66) 5'-GOG GOC CG OAA AGC TOA OAT OGA 000 COO CAT GOC O-3'(FRAO 57) (SEQ. ID NO: 67) GOC CTO OAA AGC TOA OAT OGA 000 COO CAT GOC (FRAG 58) (SEQ. ID NO: 68) GOC CG OAA AOC TGA OAT OGA 000 COG CAT 00 (FRAG 59) (SEQ. ID NO: 69) GOC CTO OAA AGG TGA OAT OGA 000 COO CAT G0-3' (FRAG 60) (SEQ. ID NO: GOC CGO OAA AGC TGA OAT OGA 000 COO CAT (FRAG 61) (SEQ. ID NO: 71) 5'-GOC GOC GTG, OAA AOC TOA OAT OGA 000 COO CA-3'(FRAG 62) (SEQ. ID NO: 72) GOC CTO OAA AG TOA OAT OGA 000 COO C-3- (FRAG 63) (SEQ. ID NO: 73) GOC CGO OAA AGC! TOA OAT OGA 000 COO (FRAG 64) (SEQ. ID NO: 74) 122 OGC CTG GAA AGC TGA GAT GGA GOG CG (FRAG 65) (SEQ. ID NO: OGC CTG GAA AGC TGA OAT GGA GOG C (FR-AG 66) (SEQ. ID NO: 76) GGC CTG GAA AOC TGA GAT GOA GGO (FRAG 67) (SEQ. ID NO: 77) GGC CTG GAA AGC TOA GAT GGA GG (FRAO 68) (SEQ. ID NO: 78) 5'-GOC GGC CTG GAA AGC TOA GAT GGA G (FRAG 69) (SEQ. ID NO: 79) GGC CTG GAA AGC TGA GAT OGA (FRAG 70) (SEQ. ID NO: GOC CTG GAA AGC TGA GAT GG (FRAG 7 1) (SEQ. ID NO: 8 1) GOC CTG GAA AGC TGA OAT G (FRAG 72) (SEQ. ID NO: 82) GGC CTO GAA AOC TGA GAT (FRAG 73) (SEQ. ID NO: 83) 5'-GOC GGC CTG GAA AGC TGA OA-3'(FRAG 74) (SEQ. ID NO: 84) GGC CTG GAA AOC TOA G-3- (FRAO 75) (SEQ. ID NO: GGC CTO GAA AOC TGA-3' (FRAG 76) (SEQ. ID NO: 86) GGC CTO OAA AGC TG-3' (FRAG 77) (SEQ. ID NO: 87) GGC CTG GAA AGC T-3- (FRAG 78) (SEQ. ID NO: 88) 5'-GOC GGC CTG GAA AGC-3' (FRAG 79) (SEQ. ID NO: 89) GGC CTG GAA AO-3' (FRAG 80) (SEQ. ID NO: GGC CTO GAA A-3'(FRAG 81) (SEQ. ID NO: 91) GGC CTG OAA-3' (FRAG 82) (SEQ. ID NO: 92) OGC CTG GA-3' (FRAG 83) (SEQ. ID NO: 93) 5'-OGC GOC CTG G-3' (FRAG 84) (SEQ. ID NO: 94) GOC CTG OAA AGC TGA GAT OGA GO COG CAT GOC G CAC AGG CTG GOC-3' (FRAG 85) (SEQ. ID NO: GOC CTO GAA AOC TOA GAT GOA GG CGG CAT GGC GGO CAC AGO CTO GG-3' (FRAG 86) (SEQ. ID NO: 96) 5'-GC GGC CTG OAA AOC TGA GAT OGA OGG CGG CAT OGC GOG CAC AGG CTG 0-3' (FRAG 87) (SEQ. ID NO: 97) GOC CTO OAA AGC TOA OAT GGA GGG CGO CAT GGC GGG CAC AGG CTG (FRAG 88) (SEQ. ID NO: 98) OGC CTG GAA AGC TGA GAT GOA GOG CGG CAT GGC GGG CAC AGO CT-3' (FRAG 89) (SEQ. ID NO: 99) GGC CTG GAA AGC TGA GAT GGA GO COO CAT GGC GGG CAC AGO C-3' (FRAG 90) (SEQ. ID NO: 100) GOC CTO GAA AOC TOA GAT GGA GO CGG CAT GGC GGG CAC AGG (FRAG 9 1) (SEQ. ID NO: 101) 5'-OC OGC CTG OAA AGC TOA OAT OGA 000 COO CAT GGC GGG CAC AG-3' (FRAG 92) (SEQ. ID NO: 102) GOC CTO OAA AOC TOA OAT OGA 000 COO CAT GOC 000 CAC A-3'(FRAO 93) (SEQ. ID NO: 103) GOC CTO OAA AOC TOA OAT OOA 000 COO CAT GOC 000 CAC-3' (FRAO 94) (SEQ. ID NO: 104) GOC CTO OAA AOC TOA OAT OGA 000 COG CAT GOC 000 CA-3'(FRAG 95) (SEQ. ID NO: 105) GOC CTO GAA AOC TOA OAT OGA 000 COO CAT GOC 000 C-3' (FRAG 96) (SEQ. ID NO: 106) 5'-OC GOC CTG OAA AOC TOA OAT OGA 000 COO CAT GOC 000 (FRAG 97) (SEQ. ID NO: 107) GOC CTO OAA AOC TOA OAT OGA 000 COO CAT GOC 00-3' (FRAG 98) (SEQ. ID NO: 108) GOC CTO OAA AOC TOA OAT OGA 000 COO CAT GOC 0-3' (FRAG 99) (SEQ. ID NO: 109) GOC CTO OAA AGC TOA OAT OOA 000 COO CAT GOC (FRAG 100) (SEQ. ID NO: 110) GOC CTO OAA AOC TOA OAT OOA 000 COO CAT 00 (FRAG 101) (SEQ. ID NO: I111) 5'-OC GOC CTO OAA AOC TOA OAT OGA 000 COO CAT G0-3- (FRAG 102) (SEQ. ID NO: 112) GOC CTG OAA AOC TOA OAT OGA 000 COO CAT (FRAG 103) (SEQ. ID NO: 113) GOC CTG OAA AOC TGA OAT OGA 000 COO CA-3' (FRAO 104) (SEQ. ID NO: 114) GOC CTO GAA AGC TOA OAT OGA 000 COO C-3- (FRAO 105) (SEQ. ID NO: 115) GOC CTO OAA AOC TOA OAT OGA 000 COO (FRAO 106) (SEQ. ID NO: 116) 5'-OC GOC CTO GAA AOC TOA OAT OGA 000 CO (FRAG 107) (SEQ. ID NO: 117) GOC CTG OAA AOC TOA OAT OGA 000 C (FRAG 108) (SEQ. ID NO: 118) GOC CTG OAA AOC TOA OAT OGA 000 (FRAG 109) (SEQ. ID NO: 119) GOC CTO OAA AOC TGA OAT OGA 00 (FRAG 1 10) (SEQ. ID NO: 120) OOC CTO OAA AOC TGA OAT OGA 0 (FRAG I111) (SEQ. ID NO: 121) 5'-GC GOC CTG GAA AOC TOA OAT OGA (FRAG 112) (SEQ. ID NO: 122) GOC CTG OAA AOC TOA OAT 00 (FRAG 113) (SEQ. ID NO: 123) OOC CTG OAA AGC TOA OAT 0 (FRAG 114) (SEQ. ID NO: 124) GOC CTG OAA AOC TOA OAT (FRAG 115) (SEQ. ID NO: 125) GOC CTG OAA AOC TGA GA-3- (FRAG 116) (SEQ. ID NO: 126) 5'-GC GOC CTG OAA AOC TOA 0-3' (FRAG 117) (SEQ. ID NO: 127) GOC CTO GAA AOC TOA-3- (FRAG 118) (SEQ. ID NO: 128) GOC CTO OAA AOC TG-3' (FRAG 119) (SEQ. ID NO: 129) GOC CTO OAA AOC T-3- (FRAG 120) (SEQ. ID NO: 130) GOC CTO GAA AOC-3' (FRAG 12 1) (SEQ. ID NO: 131) 5'-OC GOC CTO GAA AO-3'(FRAG 122) (SEQ. ID NO: 132) GOC CTO OAA A-3- (FRAG 123) (SEQ. ID NO: 133) GOC CTG GAA-3' (FRAG 124) (SEQ. ID NO: 134) GOC CTG GA-3' (FRAG 125) (SEQ. ID NO: 135) GOC CTG OAA AOYC TOA OAT OGA 000 COG CAT GOC 000 CAC AGO CTO GGC-3' (FRAG 126) (SEQ. ID NO: 136) GOC CTG GAA AOC TGA OAT OGA 000 COO CAT GOC 000 CAC AGO CTO 00-3' (FRAG 127) (SEQ. ID NO: 137) 123 GGC CTG GAA AGC TGA OAT GGA GOG COG CAT GGC GG0 CAC AGG CTO G-3- (FRAG 128) (SEQ. ID NO: 138) GGC CTG GAA AGC TGA GAT OGA GGG CGG CAT GGC GGG GAG AGO CTO (FRAG 129) (SEQ. ID NO: 139) GGC CTG OAA AGC TGA GAT GGA GGG COG CAT GGC GGG GAG AGO CT-3' (FRAG 130) (SEQ. ID NO: 140) GGC CTG OAA AGC TGA GAT OGA GOG CGG CAT GOC GO GAG AGO C-3' (FRAG 13 1) (SEQ. ID NO: 141) 5'-C GGC CTG OAA AGC TGA GAT GGA GOG CGG CAT GGC GGG GAG AGG (FRAG 132) (SEQ. ID NO: 142) GGC CTO OAA AOC TGA GAT GGA GGO CGG CAT GGC GGG GAG AG-3- (FRAG 133) (SEQ. ID NO: 143) GGC GTG OAA AGC TOA GAT GGA GGG CGG CAT OGC GGG GAG A-3'(FRAG 134) (SEQ. ID NO: 144) GOC CTG GAA AGC TGA GAT GGA GGG CGG CAT GOC GGG GAC-3' (FRAG 135) (SEQ. ID NO: 145) GOC CTG OAA AOC TOA OAT OGA GO COO CAT GGC 000 GA-3'(FRAG 136) (SEQ. ID NO: 146) 5'-C GOC CTG GAA AGC TOA OAT OGA 000 COG CAT GOC 000 G-3' (FRAG 137) (SEQ. ID NO: 147) OOC CTG GAA AGC TOA OAT OGA 000 COO CAT GOC GO (FRAG 138) (SEQ. ID NO: 148) OOC CTG OAA AGC TOA OAT OGA 000 COO CAT OG G0-3' (FRAG 139) (SEQ. ID NO: 149) CTO OAA AOC TOA OAT OOA GOG GGG CAT OGC 0-3' (FRAO 140) (SEQ. ID NO: 150) GOC CTG OAA AOC TGA OAT OOA 000 COO CAT OOC (FRAG 141) (SEQ. ID NO: 151) 5'-C GG CTO OAA AOC TGA OAT OGA 000 COO CAT 00 (FRAG 142) (SEQ. ID NO: 152) GOC CTO OAA AOC TGA OAT OOA 000 COG CAT 0 (FRA 143) (SEQ. ID NO: 153) GG CTO OAA AGC TGA OAT OOA 000 COO CAT (FRAO 144) (SEQ. ID NO: 154) GOC CTG OAA AGC TGA OAT OGA 000 COG CA-3' (FRAG 145) (SEQ. ID NO: 155) GOC CTG OAA AOC TOA OAT OGA 000 COG G-3' (FRAG 146) (SEQ. ID NO: 156) 5'-C GOC CTO OAA AGC TOA OAT OGA 000 COG (FRAG 147) (SEQ. ID NO: 157) GOC CTG OAA AGC TOA OAT OGA 000 CO (FRAG 148) (SEQ. ID NO: 158) GOC CTO OAA AOC TOA OAT OGA 000 C (FRAO 148) (SEQ. ID NO: 159) GOC CG OAA AG TOA OAT OGA GO (FRAO 150) (SEQ. ID NO: 160) GOC CTO OAA AGG TOA OAT OGA 00 (FRAO 151) (SEQ. ID NO: 161) 5'-C GOC CTG GAA AGC TOA OAT OGA 0 (FRAG 152) (SEQ. ID NO: 162) GOC CTG OAA AGC TOA OAT GOA (FRAO 153) (SEQ. ID NO: 163) OGC CG GAA AOC TOA OAT 00 (FRAG 154) (SEQ. ID NO: 164) OG CTG OAA AOC TOA OAT 0 (FRAG 155) (SEQ. ID NO: 165) OOC GTG GAA AOC TOA OAT (FRAG 156) (SEQ. ID NO: 166) 5'-C GG CG GAA AG TGA OA-3' (FRAO 157) (SEQ. ID NO: 167) GOC CTG OAA AOC TOA 0-3' (FRAG 158) (SEQ. ID NO: 168) GOC CTG OAA AOC TGA-3' (FRAO 159) (SEQ. ID NO: 169) GOC CTO OAA AOC TG-3' (FRAO 160) (SEQ. ID NO: 170) GOC CTO OAA AOC T-3- (FRAG 161) (SEQ. ID NO: 171) 5'-C GOC CTO OAA AOC-3' (FRAO 162) (SEQ. ID NO: 172) GOC CTO OAA AO-3' (FRAO 163) (SEQ. ID NO: 173) GGC CG OAA A-3- (FRAG 164) (SEQ. ID NO: 174) GG GTG OAA-3' (FRAG 165) (SEQ. ID NO: 175) OG CTG GAA AGC TGA OAT OGA 000 COO CAT OGC 000 GAG AGO GTG GGC-3' (FRAG 166) (SEQ. ID NO: 176) GG CG OAA AG TOA OAT OGA 000 COO CAT GG 000 GAG AGO GTG 00-3' (FRAG 167) (SEQ. ID NO: 177) GG CTO GAA AGC TGA OAT OGA 000 COO CAT GOC 000 GAG AGO CTG 0-3' (FRAG 168) (SEQ. ID NO: 178) GG CTO OAA AGG TGA OAT OGA 000 COO CAT GOC 000 GAG AOO CTG (FRAG 169) (SEQ. ID NO: 179) GOC CTO OAA AGG TGA OAT OGA 000 COO CAT GOC 000 GAG AGO CT-3'(FRAO 170) (SEQ. ID NO: 180) GOC CTO GAA AOC TGA OAT GOA 000 COG CAT OGC 000 GAG AGO C-3- (FRAO 17 1) (SEQ. ID NO: 181) GOC CTO OAA AG TGA OAT GOA 000 COO CAT GGC 000 GAG AGO (FRAG 172) (SEQ. ID NO: 182) GOC CTG GAA AG TGA OAT OGA 000 COO CAT OGC 000 GAG AO-3- (FRAG 173) (SEQ. ID NO: 183) GOC CTO OAA AGC TOA OAT OOA 000 COO CAT OOC 000 GAG A-3- (FRAG 174) (SEQ. ID NO: 184) GGC CTG GAA AGC TGA OAT OGA 000 COO CAT GGC 000 GAC-3' (FRAG 175) (SEQ. ID NO: 185) OGC CTG OAA AGC TOA OAT GOA 000 COG CAT GO-C 000 GA-3' (FRAG 176) (SEQ. ID NO: 186) OOC CTG GAA AGC TOA GAT GOA GO CGO CAT GO-C GOG G-3' (FRAG 177) (SEQ. ID NO: 187) OO-C CTG GAA AGC TOA OAT OGA 000 COG CAT GOC GO (FRAG 178) (SEQ. ID NO: 188) GGC CTO GAA AOC TGA OAT OGA 000 COG CAT GOC 00-3' (FRAG 179) (SEQ. ID NO: 189) GOC CTG GAA AOC TGA OAT OGA 000 COO CAT GOC 0-3' (FRAG 180) (SEQ. ID NO: 190) GGC CTO OAA AOC TGA OAT OGA 000 COG CAT GOC (FRAG 181) (SEQ. ID NO: 191) GOC CTG OAA AOC TOA OAT OGA 000 COG CAT 00 (FRAG 182) (SEQ. ID NO: 192) GOC CTG GAA AOC TOA OAT OOA 000 COG CAT G0-3- (FRAG 183) (SEQ. ID NO: 193) GOC CTG OAA AOC TOA OAT GOA 000 COG CAT (FRAG 184) (SEQ. ID NO: 194) GOC CTO OAA AOC TOA OAT GOA 000 COG CA-3' (FRAG 185) (SEQ. ID NO: 195) GOC CTO OAA AGC TOA OAT OOA 000 COG C-3' (FRAO 186) (SEQ. ID NO: 196) OOC CTO OAA AOC TOA OAT OOA 000 COG (FRAG 187) (SEQ. ID NO: 197) GOC CTG GAA AGG TGA OAT OGA 000 CO (FRAG 188) (SEQ. ID NO: 198) GOC CTO OAA AOC TOA OAT OGA 000 C (FRAG 189) (SEQ. ID NO: 199) GOC CTG GAA AOC TGA OAT OGA 000 (FRAG 190) (SEQ. ID NO: 200) OG CTG OAA AGC TGA OAT OGA 00 (FRAO 191) (SEQ. ID NO: 201) GOC CG OAA AOC TGA OAT OGA 0 (FRAG 192) (SEQ. ID NO: 202) 124 GGC CTG GAA AGC TGA GAT GGA (FRAG 193) (SEQ. ID NO: 203) GGC CTG GAA AGC TGA GAT GG (FRAG 194) (SEQ. ID NO: 204) GGC CTG GAA AGC TGA GAT G (FRAG 195) (SEQ. ID NO: 205) GGC CTG GAA AGC TGA GAT (FRAG 196) (SEQ. ID NO: 206) GGC CTG GAA AGC TGA GA-3' (FRAG 197) (SEQ. ID NO: 207) GGC CTG GAA AGC TGA G-3' (FRAG 198) (SEQ. ID NO: 208) GGC CTG GAA AGC TGA-3' (FRAG 199) (SEQ. ID NO: 209) GGC CTG GAA AGC TG-3' (FRAG 200 (SEQ. ID NO: 210) GGC CTG GAA AGC T-3' (FRAG 201) (SEQ. ID NO: 211) GGC CTG GAA AGC-3' (FRAG 202) (SEQ. ID NO: 212) GGC CTG GAA AG-3' (FRAG 203) (SEQ. ID NO: 213) GGC CTG GAA A-3' (FRAG 204) (SEQ. ID NO: 214) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 205) (SEQ. ID NO: 215) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 206) (SEQ. ID NO: 216) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 207) (SEQ. ID NO: 217) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 208) (SEQ. ID NO: 218) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3'(FRAG 209) (SEQ. ID NO: 219) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3'(FRAG 210) (SEQ. ID NO: 220) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3'(FRAG 211) (SEQ. ID NO: 221) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 212) (SEQ. ID NO: 222) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 213) (SEQ. ID NO: 223) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 214) (SEQ. ID NO: 224) GC CTO GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 215) (SEQ. ID NO: 225) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 216) (SEQ. ID NO: 226) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3'(FRAG 217) (SEQ. ID NO: 227) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3'(FRAG 218) (SEQ. ID NO: 228) GC CTO GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 219) (SEQ. ID NO: 229) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC (FRAG 220) (SEQ. ID NO: 230) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG (FRAG 221) (SEQ. ID NO: 231) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3'(FRAG 222) (SEQ. ID NO: 232) GC CTG GAA AGC TGA GAT GGA GGG CGG CAT (FRAG 223) (SEQ. ID NO: 233) GC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 224) (SEQ. ID NO: 234) GC CTG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 225) (SEQ. ID NO: 235) GC CTG GAA AGC TGA GAT GGA GGG CGG -3'(FRAG 226) (SEQ. ID NO: 236) GC CTG GAA AGC TGA GAT GGA GGG CG (FRAG 227) (SEQ. ID NO: 237) GC CTG GAA AGC TGA GAT GGA GGG C (FRAG 228) (SEQ. ID NO: 238) GC CTG GAA AGC TGA GAT GGA GGG -3'(FRAG 229) (SEQ. ID NO: 239) GC CTG GAA AGC TGA GAT GGA GG (FRAG 230) (SEQ. ID NO: 240) GC CTG GAA AGC TGA GAT GGA G (FRAG 231) (SEQ. ID NO: 241) GC CTG GAA AGC TGA GAT GGA (FRAG 232) (SEQ. ID NO: 242) GC CTG GAA AGC TGA GAT GG (FRAG 233) (SEQ. ID NO: 243) GC CTG GAA AGC TGA GAT G (FRAG 234) (SEQ. ID NO: 244) GC CTG GAA AGC TGA GAT (FRAG 235) (SEQ. ID NO: 245) GC CTG GAA AGC TGA GA-3' (FRAG 236) (SEQ. ID NO: 246) GC CTG GAA AGC TGA G-3' (FRAG 237) (SEQ. ID NO: 247) GC CTG GAA AGC TGA-3' (FRAG 238) (SEQ. ID NO: 248) GC CTG GAA AGC TG-3' (FRAG 239) (SEQ. ID NO: 249) GC CTG GAA AGC T-3' (FRAG 240) (SEQ. ID NO: 250) GC CTG GAA AGC-3' (FRAG 241) (SEQ. ID NO: 251) GC CTG GAA AG-3' (FRAG 242) (SEQ. ID NO: 252) C CTG GAA AGC TGA GAT GG A GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 243) (SEQ. ID NO: 253) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3'(FRAG 244) (SEQ. ID NO: 254) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 245) (SEQ. ID NO: 255) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 246) (SEQ. ID NO: 256) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3'(FRAG 247) (SEQ. ID NO: 257) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3'(FRAG 248) (SEQ. ID NO: 258) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG (FRAG 249) (SEQ. ID NO: 259) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 250) (SEQ. ID NO: 260) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 251) (SEQ. ID NO: 261) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 252) (SEQ. ID NO: 262) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 253) (SEQ. ID NO: 263) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 254) (SEQ. ID NO: 264) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3'(FRAG 255) (SEQ. ID NO: 265) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 256) (SEQ. ID NO: 266) 125 C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 257) (SEQ. ID NO: 267) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC (FRAG 258) (SEQ. ID NO: 268) C CTG GAA AGC TGA GAT GGA GGG CGG CAT GG (FRAG 259) (SEQ. ID NO: 269) C CTG GAA AGC TGA GAT GGA GGG CGG CAT G (FRAG 260) (SEQ. ID NO: 270) C CTG GAA AGC TGA GAT GGA GGG CGG CAT (FRAG 261)(SEQ. ID NO: 271) C CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 262) (SEQ. ID NO: 272) C CTG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 263) (SEQ. ID NO: 273) C CTG GAA AGC TGA GAT GGA GGG CGG (FRAG 264) (SEQ. ID NO: 274) C CTG GAA AGC TGA GAT GGA GGG CG (FRAG 265) (SEQ. ID NO: 275) C CTG GAA AGC TGA GAT GGA GGG C (FRAG 266) (SEQ. ID NO: 276) C CTG GAA AGC TGA GAT GGA GGG (FRAG 267) (SEQ. ID NO: 277) C CTG GAA AGC TGA GAT GGA GG (FRAG 268) (SEQ. ID NO: 278) C CTG GAA AGC TGA GAT GGA G (FRAG 269) (SEQ. ID NO: 279) C CTG GAA AGC TGA GAT GGA (FRAG 270) (SEQ. ID NO: 280) C CTG GAA AGC TGA GAT GG (FRAG 271) (SEQ. ID NO: 281) C CTG GAA AGC TGA GAT G (FRAG 272) (SEQ. ID NO: 282) C CTG GAA AGC TGA GAT (FRAG 273) (SEQ. ID NO: 283) C CTG GAA AGC TGA GA-3' (FRAG 274) (SEQ. ID NO: 284) C CTG GAA AGC TGA G-3'(FRAG 275) (SEQ. ID NO: 285) C CTG GAA AGC TGA-3' (FRAG 276) (SEQ. ID NO: 286) C CTG GAA AGC TG-3' (FRAG 277) (SEQ. ID NO: 287) C CTG GAA AGC T-3' (FRAG 278) (SEQ. ID NO: 288) C CTG GAA AGC-3' (FRAG 279) (SEQ. ID NO: 289) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 280) (SEQ. ID NO: 290) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 281) (SEQ. ID NO: 291) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 282) (SEQ. ID NO: 292) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3'(FRAG 283) (SEQ. ID NO: 293) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 284) (SEQ. ID NO: 294) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 285) (SEQ. ID NO: 295) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG (FRAG 286) (SEQ. ID NO: 296) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 287) (SEQ. ID NO: 297) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 288) (SEQ. ID NO: 298) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 289) (SEQ. ID NO: 299) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3'(FRAG 290) (SEQ. ID NO: 300) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3'(FRAG 291) (SEQ. ID NO: 301) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3'(FRAG 292) (SEQ. ID NO: 302) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 293) (SEQ. ID NO: 303) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 294) (SEQ. ID NO: 304) CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC (FRAG 295) (SEQ. ID NO: 305) CTG GAA AGC TGA GAT GGA GGG CGG CAT GG (FRAG 296) (SEQ. ID NO: 306) CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3'(FRAG 297) (SEQ. ID NO: 307) CTG GAA AGC TGA GAT GGA GGG CGG CAT (FRAG 298) (SEQ. ID NO: 308) CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 299) (SEQ. ID NO: 309) CTG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 300) (SEQ. ID NO: 310) CTG GAA AGC TGA GAT GGA GGG CGG (FRAG 301) (SEQ. ID NO: 311) CTO GAA AGC TGA GAT GGA GGG CG (FRAG 302) (SEQ. ID NO: 312) CTG GAA AGC TGA GAT GGA GGG C (FRAG 303) (SEQ. ID NO: 313) CTG GAA AGC TGA GAT GGA GGG (FRAG 304) (SEQ. ID NO: 314) CTG GAA AGC TGA GAT GGA GG (FRAG 305) (SEQ. ID NO: 315) CTG GAA AGC TGA GAT GGA G (FRAG 306) (SEQ. ID NO: 316) CTG GAA AGC TGA GAT GGA (FRAG 307) (SEQ. ID NO: 317) CTG GAA AGC TGA GAT GG (FRAG 308) (SEQ. ID NO: 318) CTG GAA AGC TGA GAT G (FRAG 309) (SEQ. ID NO: 319) CTG GAA AGC TGA GAT (FRAG 310) (SEQ. ID NO: 320) CTG GAA AGC TGA GA-3' (FRAG 311) (SEQ. ID NO: 321) CTG GAA AGC TGA G-3' (FRAG 312) (SEQ. ID NO: 322) CTG GAA AGC TGA-3' (FRAG 313) (SEQ. ID NO: 323) CTG GAA AGC TG-3' (FRAG 314) (SEQ. ID NO: 324) CTG GAA AGC T-3' (FRAG 315) (SEQ. ID NO: 325) TO GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 316) (SEQ. ID NO: 326) TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 317) (SEQ. ID NO: 327) TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3'(FRAG 318) (SEQ. ID NO: 328) TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3'(FRAG 319) (SEQ. ID NO: 329) TO GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 320) (SEQ. ID NO: 330) TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 321) (SEQ. ID NO: 331) TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG (FRAG 322) (SEQ. ID NO: 332) TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3'(FRAG 323) (SEQ. ID NO: 333) 126 TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 324)(SEQ. ID NO: 334) TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 325) (SEQ. ID NO: 335) TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 326) (SEQ. ID NO: 336) TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 327) (SEQ. ID NO: 337) TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG (FRAG 328) (SEQ. ID NO: 338) TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 329) (SEQ. ID NO: 339) TG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 330) (SEQ. ID NO: 340) TG GAA AGC TGA GAT GGA GGG CGG CAT GGC (FRAG 331) (SEQ. ID NO: 341) TG GAA AGC TGA GAT GGA GGG CGG CAT GG (FRAG 332) (SEQ. ID NO: 342) TG GAA AGC TGA GAT GGA GGG CGG CAT G (FRAG 333) (SEQ. ID NO: 343) TG GAA AGC TGA GAT GGA GGG CGG CAT (FRAG 334) (SEQ. ID NO: 344) TG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 335) (SEQ. ID NO: 345) TG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 336) (SEQ. ID NO: 346) TG GAA AGC TGA GAT GGA GGG CGG (FRAG 337) (SEQ. ID NO: 347) TG GAA AGC TGA GAT GGA GGG CG (FRAG 338) (SEQ. ID NO: 348) TO GAA AGC TGA GAT GGA GGG C (FRAG 339) (SEQ. ID NO: 349) TG GAA AGC TGA GAT GGA GGG -3'(FRAG 340) (SEQ. ID NO: 350) TG GAA AGC TGA GAT GGA GG (FRAG 341) (SEQ. ID NO: 351) TG GAA AGC TGA GAT GGA G (FRAG 342) (SEQ. ID NO: 352) TG GAA AGC TGA GAT GGA (FRAG 343) (SEQ. ID NO: 353) TG GAA AGC TGA GAT GG (FRAG 344) (SEQ. ID NO: 354) TO GAA AGC TGA GAT G -3'(FRAG 345) (SEQ. ID NO: 355) TG GAA AGC TGA GAT (FRAG 346) (SEQ. ID NO: 356) TG GAA AGC TGA GA-3' (FRAG 347) (SEQ. ID NO: 357) TG GAA AGC TGA G-3' (FRAG 348) (SEQ. ID NO: 358) TG GAA AGC TGA-3' (FRAG 349) (SEQ. ID NO: 359) TG GAA AGC TG-3' (FRAG 350) (SEQ. ID NO: 360) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 351) (SEQ. ID NO: 361) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3'(FRAG 352) (SEQ. ID NO: 362) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3'(FRAG 353) (SEQ. ID NO: 363) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 354) (SEQ. ID NO: 364) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 355) (SEQ. ID NO: 365) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3'(FRAG 356) (SEQ. ID NO: 366) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG (FRAG 357) (SEQ. ID NO: 367) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 358) (SEQ. ID NO: 368) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 359) (SEQ. ID NO: 369) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 360) (SEQ. ID NO: 370) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 361) (SEQ. ID NO: 371) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 362) (SEQ. ID NO: 372) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG (FRAG 363) (SEQ. ID NO: 373) G GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 364) (SEQ. ID NO: 374) G GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 365) (SEQ. ID NO: 375) G GAA AGC TGA GAT GGA GGG CGG CAT GGC (FRAG 366) (SEQ. ID NO: 376) G GAA AGC TGA GAT GGA GGG CGG CAT GG (FRAG 367) (SEQ. ID NO: 377) G GAA AGC TGA GAT GGA GGG CGG CAT G (FRAG 368) (SEQ. ID NO: 378) G GAA AGC TGA GAT GGA GGG CGG CAT (FRAG 369) (SEQ. ID NO: 379) G GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 370) (SEQ. ID NO: 380) G GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 371) (SEQ. ID NO: 381) G GAA AGC TGA GAT GGA GGG CGG (FRAG 372) (SEQ. ID NO: 382) G GAA AGC TGA GAT GGA GGG CG (FRAG 373) (SEQ. ID NO: 383) G GAA AGC TGA GAT GGA GGG C (FRAG 374) (SEQ. ID NO: 384) G GAA AGC TGA GAT GGA GGG (FRAG 375) (SEQ. ID NO: 385) G GAA AGC TGA GAT GGA GG (FRAG 376) (SEQ. ID NO: 386) G GAA AGC TGA GAT GGA G (FRAG 377) (SEQ. ID NO: 387) G GAA AGC TGA GAT GGA (FRAG 378) (SEQ. ID NO: 388) G GAA AGC TGA GAT GG -3'(FRAG 379) (SEQ. ID NO: 389) G GAA AGC TGA GAT G (FRAG 380) (SEQ. ID NO: 390) G GAA AGC TGA GAT (FRAG 381) (SEQ. ID NO: 391) G GAA AGC TGA GA-3' (FRAG 382) (SEQ. ID NO: 392) G GAA AGC TGA G-3' (FRAG 383) (SEQ. ID NO: 393) G GAA AGC TGA-3' (FRAG 384) (SEQ. ID NO: 394) GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3'(FRAG 385) (SEQ. ID NO: 395) GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3'(FRAG 386) (SEQ. ID NO: 396) GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3'(FRAG 387) (SEQ. ID NO: 397) GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 388) (SEQ. ID NO: 398) GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 389) (SEQ. ID NO: 399) GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 390) (SEQ. ID NO: 400) 127 GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG (FRAG 391)(SEQ. ID NO: 401) GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3'(FRAG 392) (SEQ. ID NO: 402) GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 393) (SEQ. ID NO: 403) GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3'(FRAG 394) (SEQ. ID NO: 404) GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 395) (SEQ. ID NO: 405) GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3'(FRAG 396) (SEQ. ID NO: 406) GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3'(FRAG 397) (SEQ. ID NO: 407) GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3'(FRAG 398) (SEQ. ID NO: 408) GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 399)(SEQ. ID NO: 409) GAA AGC TGA GAT GGA GGG CGG CAT GGC -3'(FRAG 400) (SEQ. ID NO: 410) GAA AGC TGA GAT GGA GGG CGG CAT GG (FRAG 401) (SEQ. ID NO: 411) GAA AGC TGA GAT GGA GGG CGG CAT G -3'(FRAG 402) (SEQ. ID NO: 412) GAA AGC TGA GAT GGA GGG CGG CAT -3'(FRAG 403) (SEQ. ID NO: 413) GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 404) (SEQ. ID NO: 414) GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 405) (SEQ. ID NO: 415) GAA AGC TGA GAT GGA GGG CGG (FRAG 406) (SEQ. ID NO: 416) GAA AGC TGA GAT GGA GGG CG (FRAG 407) (SEQ. ID NO: 417) GAA AGC TGA GAT GGA GGG C (FRAG 408) (SEQ. ID NO: 418) GAA AGC TGA GAT GGA GGG (FRAG 409) (SEQ. ID NO: 419) GAA AGC TGA GAT GGA GG -3'(FRAG 410) (SEQ. ID NO: 420) GAA AGC TGA GAT GGA G -3'(FRAG 411)(SEQ. ID NO: 421) GAA AGC TGA GAT GGA (FRAG 412) (SEQ. ID NO: 422) GAA AGC TGA GAT GG (FRAG 413) (SEQ. ID NO: 423) GAA AGC TGA GAT G (FRAG 414) (SEQ. ID NO: 424) GAA AGC TGA GAT -3'(FRAG 415) (SEQ. ID NO: 425) GAA AGC TGA GA-3' (FRAG 416) (SEQ. ID NO: 426) GAA AGC TGA G-3' (FRAG 417) (SEQ. ID NO: 427) AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 418)(SEQ. ID NO: 428) AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 419)(SEQ. ID NO: 429) AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG 0-3'(FRAG 420) (SEQ. ID NO: 430) AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 421) (SEQ. ID NO: 431) AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 422) (SEQ. ID NO: 432) AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 423) (SEQ. ID NO: 433) AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3'(FRAG 424) (SEQ. ID NO: 434) AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3'(FRAG 425) (SEQ. ID NO: 435) AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 426) (SEQ. ID NO: 436) AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 427) (SEQ. ID NO: 437) AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 428) (SEQ. ID NO: 438) AA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3'(FRAG 429) (SEQ. ID NO: 439) AA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3'(FRAG 430) (SEQ. ID NO: 440) AA AGC TGA GAT GGA GGG CGG CAT GGC GG-3'(FRAG 431) (SEQ. ID NO: 441) AA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 432) (SEQ. ID NO: 442) AA AGC TGA GAT GGA GGG CGG CAT GGC (FRAG 433) (SEQ. ID NO: 443) AA AGC TGA GAT GGA GGG CGG CAT GG (FRAG 434) (SEQ. ID NO: 444) AA AGC TGA GAT GGA GGG CGG CAT G -3'(FRAG 435) (SEQ. ID NO: 445) AA AGC TGA GAT GGA GGG CGG CAT (FRAG 436) (SEQ. ID NO: 446) AA AGC TGA GAT GGA GGG CGG CA-3'(FRAG 437) (SEQ. ID NO: 447) AA AGC TGA GAT GGA GGG CGG C-3' (FRAG 438) (SEQ. ID NO: 448) AA AGC TGA GAT GGA GGG CGG (FRAG 439) (SEQ. ID NO: 449) AA AGC TGA GAT GGA GGG CG -3'(FRAG 440) (SEQ. ID NO: 450) AA AGC TGA GAT GGA GGG C (FRAG 441) (SEQ. ID NO: 451) AA AGC TGA GAT GGA GGG (FRAG 442) (SEQ. ID NO: 452) AA AGC TGA GAT GGA GG -3'(FRAG 443) (SEQ. ID NO: 453) AA AGC TGA GAT GGA G (FRAG 444) (SEQ. ID NO: 454) AA AGC TGA GAT GGA (FRAG 445) (SEQ. ID NO: 455) AA AGC TGA GAT GG (FRAG 446) (SEQ. ID NO: 456) AA AGC TGA GAT G (FRAG 447) (SEQ. ID NO: 457) AA AGC TGA GAT (FRAG 448) (SEQ. ID NO: 458) AA AGC TGA GA-3' (FRAG 449) (SEQ. ID NO: 459) A AGC TGA GAT GGA GGGCG G CAT GGC GGG CAC AGG CTG OGGC-3'(FRAG 450) (SEQ. ID NO: 460) A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3'(FRAG451)(SEQ. ID NO: 461) A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3'(FRAG 452) (SEQ. ID NO: 462) A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 453) (SEQ. ID NO: 463) A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 454) (SEQ. ID NO: 464) A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3'(FRAG 455) (SEQ. ID NO: 465) A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3'(FRAG 456) (SEQ. ID NO: 466) A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3'(FRAG 457) (SEQ. ID NO: 467) 128 A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 458) (SEQ. ID NO: 468) A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3'(FRAG 459) (SEQ. ID NO: 469) A AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 460) (SEQ. ID NO: 470) A AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 461) (SEQ. ID NO: 471) A AGC TGA GAT GGA GGG CGG CAT GGC GGG (FRAG 462) (SEQ. ID NO: 472) A AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 463) (SEQ. ID NO: 473) A AGC TGA GAT GGA GGG CGG CAT GGC G-3'(FRAG 464) (SEQ. ID NO: 474) A AGC TGA GAT GGA GGG CGG CAT GGC (FRAG 465) (SEQ. ID NO: 475) A AGC TGA GAT GGA GGG CGG CAT GG (FRAG 466) (SEQ. ID NO: 476) A AGC TGA GAT GGA GGG CGG CAT G (FRAG 467) (SEQ. ID NO: 477) A AGC TGA GAT GGA GGG CGG CAT (FRAG 468) (SEQ. ID NO: 478) A AGC TGA GAT GGA GGG CGG CA-3' (FRAG 469) (SEQ. ID NO: 479) A AGC TGA GAT GGA GGG CGG C-3' (FRAG 470) (SEQ. ID NO: 480) A AGC TGA GAT GGA GGG CGG (FRAG 471) (SEQ. ID NO: 481) A AGC TGA GAT GGA GGG CG (FRAG 472) (SEQ. ID NO: 482) A AGC TGA GAT GGA GGG C (FRAG 473) (SEQ. ID NO: 483) A AGC TGA GAT GGA GGG (FRAG 474) (SEQ. ID NO: 484) A AGC TGA GAT GGA GG -3'(FRAG 475) (SEQ. ID NO: 485) A AGC TGA GAT GGA G -3'(FRAG 476) (SEQ. ID NO: 486) A AGC TGA GAT GGA -3'(FRAG 477) (SEQ. ID NO: 487) A AGC TGA GAT GG (FRAG 478) (SEQ. ID NO: 488) A AGC TGA GAT G (FRAG 479) (SEQ. ID NO: 489) A AGC TGA GAT (FRAG 480) (SEQ. ID NO: 490) AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3'(FRAG 481) (SEQ. ID NO: 491) AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 482) (SEQ. ID NO: 492) AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 483) (SEQ. ID NO: 493) AGC TGA GAT GGA GG CGG CAT GGC GGG CAC AGG CTG -3'(FRAG 484) (SEQ. ID NO: 494) AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3'(FRAG 485) (SEQ. ID NO: 495) AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 486) (SEQ. ID NO: 496) AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG (FRAG 487) (SEQ. ID NO: 497) AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 488) (SEQ. ID NO: 498) AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 489) (SEQ. ID NO: 499) AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 490) (SEQ. ID NO: 500) AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 491) (SEQ. ID NO: 501) AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 492) (SEQ. ID NO: 502) AGC TGA GAT GGA GGG CGG CAT GGC GGG (FRAG 493) (SEQ. ID NO: 503) AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 494) (SEQ. ID NO: 504) AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 495) (SEQ. ID NO: 505) AGC TGA GAT GGA GGG CGG CAT GGC -3'(FRAG 496) (SEQ. ID NO: 506) AGC TGA GAT GGA GGG CGG CAT GG (FRAG 497) (SEQ. ID NO: 507) AGC TGA GAT GGA GGG CGG CAT G (FRAG 498) (SEQ. ID NO: 508) AGC TGA GAT GGA GGG CGG CAT (FRAG 499) (SEQ. ID NO: 509) AGC TGA GAT GGA GGG CGG CA-3' (FRAG 500) (SEQ. ID NO: 510) AGC TGA GAT GGA GGG CGG C-3' (FRAG 501)(SEQ. ID NO: 511) AGC TGA GAT GGA GGG CGG (FRAG 502) (SEQ. ID NO: 512) AGC TGA GAT GGA GGG CG (FRAG 503) (SEQ. ID NO: 513) AGC TGA GAT GGA GGG C (FRAG 504) (SEQ. ID NO: 514) AGC TGA GAT GGA GGG (FRAG 505) (SEQ. ID NO: 515) AGC TGA GAT GGA GG -3'(FRAG 506) (SEQ. ID NO: 516) AGC TGA GAT GGA G (FRAG 507) (SEQ. ID NO: 517) AGC TGA GAT GGA (FRAG 508) (SEQ. ID NO: 518) AGC TGA GAT GG (FRAG 509) (SEQ. ID NO: 519) AGC TGA GAT G (FRAG 510) (SEQ. ID NO: 520) GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3'(FRAG 511) (SEQ. ID NO: 521) GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 512) (SEQ. ID NO: 522) GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 513) (SEQ. ID NO: 523) GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3'(FRAG 514) (SEQ. ID NO: 524) GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 515) (SEQ. ID NO: 525) GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 516) (SEQ. ID NO: 526) GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG (FRAG 517)(SEQ. ID NO: 527) GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3'(FRAG 518) (SEQ. ID NO: 528) GC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 519) (SEQ. ID NO: 529) GC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 520) (SEQ. ID NO: 530) GC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 521) (SEQ. ID NO: 531) GC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 522) (SEQ. ID NO: 532) GC TGA GAT GGA GGG CGG CAT GGC GGG (FRAG 523) (SEQ. ID NO: 533) GC TGA GAT GGA GGG CGG CAT GGC GG-3'(FRAG 524) (SEQ. ID NO: 534) 129 GC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 525) (SEQ. ID NO: 535) GC TGA GAT GGA GGG CGG CAT GGC -3'(FRAG 526) (SEQ. ID NO: 536) GC TGA GAT GGA GGG CGG CAT GG -3'(FRAG 527) (SEQ. ID NO: 537) GC TGA GAT GGA GGG CGG CAT G (FRAG 528) (SEQ. ID NO: 538) GC TGA GAT GGA GGG CGG CAT -3'(FRAG 529) (SEQ. ID NO: 539) GC TGA GAT GGA GGG CGG CA-3' (FRAG 530) (SEQ. ID NO: 540) GC TGA GAT GGA GGG CGG C-3' (FRAG 531)(SEQ. ID NO: 541) GC TGA GAT GGA GGG CGG (FRAG 532) (SEQ. ID NO: 542) GC TGA GAT GGA GGG CG (FRAG 533) (SEQ. ID NO: 543) GC TGA GAT GGA GGG C -3'(FRAG 534) (SEQ. ID NO: 544) GC TGA GAT GGA GGG -3'(FRAG 535) (SEQ. ID NO: 545) GC TGA GAT GGA GG (FRAG 536) (SEQ. ID NO: 546) GC TGA GAT GGA G (FRAG 537) (SEQ. ID NO: 547) GC TGA GAT GGA -3'(FRAG 538) (SEQ. ID NO: 548) GC TGA GAT GG -3'(FRAG 539) (SEQ. ID NO: 549) C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 540) (SEQ. ID NO: 550) C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 541) (SEQ. ID NO: 551) C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG 0-3' (FRAG 542) (SEQ. ID NO: 552) C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 543) (SEQ. ID NO: 553) C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 544) (SEQ. ID NO: 554) C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3'(FRAG 545) (SEQ. ID NO: 555) C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG (FRAG 546) (SEQ. ID NO: 556) C TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 547) (SEQ. ID NO: 557) C TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 548) (SEQ. ID NO: 558) C TGA GAT GGA GGG CGG CAT GGC GGG CAC-3'(FRAG 549) (SEQ. ID NO: 559) C TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 550) (SEQ. ID NO: 560) C TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 551)(SEQ. ID NO: 561) C TGA GAT GGA GGG CGG CAT GGC GGG -3'(FRAG 552) (SEQ. ID NO: 562) C TGA GAT GGA GGG CGG CAT GGC GG-3'(FRAG 553) (SEQ. ID NO: 563) C TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 554) (SEQ. ID NO: 564) C TGA GAT GGA GGG CGG CAT GGC -3'(FRAG 555) (SEQ. ID NO: 565) C TGA GAT GGA GGG CGG CAT GG (FRAG 556) (SEQ. ID NO: 566) C TGA GAT GGA GGG CGG CAT G (FRAG 557) (SEQ. ID NO: 567) C TGA GAT GGA GGG CGG CAT (FRAG 558) (SEQ. ID NO: 568) C TA GAT GGA GGG CGG CA-3' (FRAG 559) (SEQ. ID NO: 569) C TGA GAT GGA GGG CGG C-3' (FRAG 560) (SEQ. ID NO: 570) C TGA GAT GGA GGG CGG (FRAG 561) (SEQ. ID NO: 571) C TGA GAT GGA GGG CO (FRAG 562) (SEQ. ID NO: 572) C TGA GAT GGA GGG C -3'(FRAG 563) (SEQ. ID NO: 573) C TGA GAT GGA GGG -3'(FRAG 564) (SEQ. ID NO: 574) C TGA GAT GGA GG (FRAG 565) (SEQ. ID NO: 575) C TGA GAT GGA G -3'(FRAG 566) (SEQ. ID NO: 576) C TGA GAT GGA (FRAG 567) (SEQ. ID NO: 577) TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3'(FRAG 568) (SEQ. ID NO: 578) TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3'(FRAG 569) (SEQ. ID NO: 579) TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3'(FRAG 570) (SEQ. ID NO: 580) TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3'(FRAG 571)(SEQ. ID NO: 581) TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 572) (SEQ. ID NO: 582) TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 573) (SEQ. ID NO: 583) TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3'(FRAG 574) (SEQ. ID NO: 584) TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 575) (SEQ. ID NO: 585) TOA GAT GGA GGG CGG CAT GGC GGG CAC A-3'(FRAG 576) (SEQ. ID NO: 586) TGA GAT GGA 0GG CGG CAT GGC GGG CAC-3'(FRAG 577) (SEQ. ID NO: 587) TOA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 578) (SEQ. ID NO: 588) TOA GAT GGA GGG CGG CAT GGC GGG C-3'(FRAG 579) (SEQ. ID NO: 589) TGA GAT GGA GGG CGG CAT GGC GGG (FRAG 580) (SEQ. ID NO: 590) TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 581)(SEQ. ID NO: 591) TGA GAT GGA GGG CGG CAT GGC G-3'(FRAG 582) (SEQ. ID NO: 592) TGA GAT GGA GGG CGG CAT GGC -3'(FRAG 583) (SEQ. ID NO: 593) TGA GAT GGA GGG CGG CAT GG-3'(FRAG 584) (SEQ. M NO: 594) TGA GAT GGA GGG CGG CAT G -3'(FRAG 585) (SEQ. ID NO: 595) TGA GAT GGA GGG CGG CAT -3'(FRAG 586) (SEQ. ID NO: 596) TGA GAT GGA GGG CGG CA-3' (FRAG 587) (SEQ. ID NO: 597) TGA GAT GGA GGG CGG C-3' (FRAG 588) (SEQ. ID NO: 598) TGA GAT GGA GGG CGG (FRAG 589) (SEQ. ID NO: 599) TGA GAT GGA GGG CG (FRAG 590) (SEQ. ID NO: 600) TGAGATGGAGGGC -3'(FRAG591)(SEQ. D NO: 601) 130 TGA GAT GGA GGG (FRAG 592) (SEQ. ID NO: 602) TGA GAT GGA GG (FRAG 593) (SEQ. ID NO: 603) TGA GAT GGA G (FRAG 594) (SEQ. ID NO: 604) GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 595) (SEQ. ID NO: 605) GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 596) (SEQ. ID NO: 606) GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 597) (SEQ. ID NO: 607) GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 598) (SEQ. ID NO: 608) GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 599) (SEQ. ID NO: 609) GA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 600) (SEQ. ID NO: 610) GA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3'(FRAG 601) (SEQ. ID NO: 611) GA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 602) (SEQ. ID NO: 612) GA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 603) (SEQ. ID NO: 613) GA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 604) (SEQ. ID NO: 614) GA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 605) (SEQ. ID NO: 615) GA GAT GGA GGG CGG CAT GGC GGG C-3'(FRAG 606) (SEQ. ID NO: 616) GA GAT GGA GGG CGG CAT GGC GGG (FRAG 607) (SEQ. ID NO: 617) GA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 608) (SEQ. ID NO: 618) GA GAT GGA GGG CGG CAT GGC G-3' (FRAG 609) (SEQ. ID NO: 619) GA GAT GGA GGG CGG CAT GGC (FRAG 610) (SEQ. ID NO: 620) GA GAT GGA GGG CGG CAT GG -3'(FRAG 611) (SEQ. ID NO: 621) GA GAT GGA GGG CGG CAT G (FRAG 612) (SEQ. ID NO: 622) GA GAT GGA GGG CGG CAT (FRAG 613) (SEQ. ID NO: 623) GA GAT GGA GGG CGG CA-3' (FRAG 614) (SEQ. ID NO: 624) GA GAT GGA GGG CGG C-3' (FRAG 615) (SEQ. ID NO: 625) GA GAT GGA GGG CGG -3'(FRAG 616) (SEQ. ID NO: 626) GA GAT GGA GGG CG (FRAG 617) (SEQ. ID NO: 627) GA GAT GGA GGG C -3'(FRAG 618) (SEQ. ID NO: 628) GA GAT GGA GGG (FRAG 619) (SEQ. ID NO: 629) GA GAT GGA GG (FRAG 620) (SEQ. ID NO: 630) A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 621) (SEQ. ID NO: 631) A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 622) (SEQ. ID NO: 632) A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 623) (SEQ. ID NO: 633) A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 624) (SEQ. ID NO: 634) A GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 625) (SEQ. ID NO: 635) A GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 626) (SEQ. ID NO: 636) A GAT GGA GGG CGG CAT GGC GGG CAC AGG (FRAG 627) (SEQ. ID NO: 637) A GAT GGA GGG CGG CAT GGC GGG CAC AG-3'(FRAG 628) (SEQ. ID NO: 638) A GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 629) (SEQ. ID NO: 639) A GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 630) (SEQ. ID NO: 640) A GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 631) (SEQ. ID NO: 641) A GAT GGA GGG CGG CAT GGC GGG C-3'(FRAG 632) (SEQ. ID NO: 642) A GAT GGA GGG CGG CAT GGC GGG (FRAG 633) (SEQ. ID NO: 643) A GAT GGA GGG CGG CAT GGC GG-3' (FRAG 634) (SEQ. ID NO: 644) A GAT GGA GGG CGG CAT GGC G-3' (FRAG 635) (SEQ. ID NO: 645) A GAT GGA GGG CGG CAT GGC (FRAG 636) (SEQ. ID NO: 646) A GAT GGA GGG CGG CAT GG (FRAG 637) (SEQ. ID NO: 647) A GAT GGA GGG CGG CAT G -3'(FRAG 638) (SEQ. ID NO: 648) A GAT GGA GGG CGG CAT (FRAG 639) (SEQ. ID NO: 649) A GAT GGA GGG CGG CA-3' (FRAG 640) (SEQ. ID NO: 650) A GAT GGA GGG CGG C-3' (FRAG 641) (SEQ. ID NO: 651) A GAT GGA GGG CGG (FRAG 642) (SEQ. ID NO: 652) A GAT GGA GGG CG (FRAG 643) (SEQ. ID NO: 653) A GAT GGA GGG C (FRAG 644) (SEQ. ID NO: 654) A GAT GGA GGG (FRAG 645) (SEQ. ID NO: 655) GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3'(FRAG 646) (SEQ. ID NO: 656) GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 647) (SEQ. ID NO: 657) GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 648) (SEQ. ID NO: 658) GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 6) (SEQ. ID NO: 659) GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 650) (SEQ. ID NO: 660) GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 651) (SEQ. ID NO: 661) GAT GGA GGG CGG CAT GGC GGG CAC AGG (FRAG 652) (SEQ. ID NO: 662) GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 653) (SEQ. ID NO: 663) GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 654) (SEQ. ID NO: 664) GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 655) (SEQ. ID NO: 665) GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 656) (SEQ. ID NO: 666) GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 657) (SEQ. ID NO: 667) GAT GGA GGG CGG CAT GGC GGG (FRAG 658) (SEQ. ID NO: 668) 131 GAT GGA GGG CGG CAT GGC GG-3' (FRAG 659) (SEQ. ID NO: 669) GAT GGA GGG CGG CAT GGC G-3' (FRAG 660) (SEQ. ID NO: 670) GAT GGA GGG CGG CAT GGC (FRAG 661) (SEQ. ID NO: 671) GAT GGA GGG CGG CAT GG (FRAG 662) (SEQ. ID NO: 672) GAT GGA GGG CGG CAT G (FRAG 663) (SEQ. ID NO: 673) GAT GGA GGG CGG CAT (FRAG 664) (SEQ. ID NO: 674) GAT GGA GGG CGG CA-3' (FRAG 665) (SEQ. ID NO: 675) GAT GGA GGG CGG C-3' (FRAG 666) (SEQ. ID NO: 676) GAT GGA GGG CGG (FRAG 667) (SEQ. ID NO: 677) GAT GGA GGG CG (FRAG 668) (SEQ. ID NO: 678) GAT GGA GGG C (FRAG 669) (SEQ. ID NO: 679) AT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 670) (SEQ. ID NO: 680) AT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 671) (SEQ. ID NO: 681) AT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 672) (SEQ. ID NO: 682) AT GGA GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 673) (SEQ. ID NO: 683) AT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 674) (SEQ. ID NO: 684) AT GGA GGG CGG CAT GGC GGG CAC AGG C-3'(FRAG 675) (SEQ. ID NO: 685) AT GGA GGG CGG CAT GGC GGG CAC AGG (FRAG 676) (SEQ. ID NO: 686) AT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 677) (SEQ. ID NO: 687) AT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 678) (SEQ. ID NO: 688) AT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 679) (SEQ. ID NO: 689) AT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 680) (SEQ. ID NO: 690) AT GGA GGG CGG CAT GGC GGG C-3' (FRAG 681) (SEQ. ID NO: 691) AT GGA GGG CGG CAT GGC GGG (FRAG 682) (SEQ. ID NO: 692) AT GGA GGG CGG CAT GGC GG-3' (FRAG 683) (SEQ. ID NO: 693) AT GGA GGG CGG CAT GGC G-3' (FRAG 684) (SEQ. ID NO: 694) AT GGA GGG CGG CAT GGC (FRAG 685) (SEQ. ID NO: 695) AT GGA GGG CGG CAT GG (FRAG 686) (SEQ. ID NO: 696) AT GGA GGG CGG CAT G (FRAG 687) (SEQ. ID NO: 697) AT GGA GGG CGG CAT (FRAG 688) (SEQ. ID NO: 698) AT GGA GGG CGG CA-3' (FRAG 689) (SEQ. ID NO: 699) AT GGA GGG CGG C-3' (FRAG 690) (SEQ. ID NO: 700) AT GGA GGG CGG (FRAG 691) (SEQ. ID NO: 701) AT GGA GGG CG (FRAG 692) (SEQ. ID NO: 702) T GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 693) (SEQ. ID NO: 703) T GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 694) (SEQ. ID NO: 704) T GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 695) (SEQ. ID NO: 705) T GGA GGG CGG CAT GGC GGG CAC AGG CTG -3'(FRAG 696) (SEQ. ID NO: 706) T GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 697) (SEQ. ID NO: 707) T GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 698) (SEQ. ID NO: 708) T GGA GGG CGG CAT GGC GGG CAC AGG (FRAG 699) (SEQ. ID NO: 709) T GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 700) (SEQ. ID NO: 710) T GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 701) (SEQ. ID NO: 711) T GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 702) (SEQ. ID NO: 712) T GGA GGG CGG CAT GGC GGG CA-3'(FRAG 703) (SEQ. ID NO: 713) T GGA GGG CGG CAT GGC GGG C-3' (FRAG 704) (SEQ. ID NO: 714) T GGA GGG CGG CAT GGC GGG (FRAG 705) (SEQ. ID NO: 715) T GGA GGG CGG CAT GGC GG-3' (FRAG 706) (SEQ. ID NO: 716) T GGA GGG CGG CAT GGC G-3' (FRAG 707) (SEQ. ID NO: 717) T GGA GGG CGG CAT GGC (FRAG 708) (SEQ. ID NO: 718) T GGA GGG CGG CAT GG (FRAG 709) (SEQ. ID NO: 719) T GGA GGG CGG CAT G (FRAG 710) (SEQ. ID NO: 720) T GGA GGG CGG CAT (FRAG 711) (SEQ. ID NO: 721) T GGA GGG CGG CA-3' (FRAG 712) (SEQ. ID NO: 722) T GGA GGG CGG C-3' (FRAG 713) (SEQ. ID NO: 723) T GGA GGG CGG -3'(FRAG 714) (SEQ. ID NO: 724) GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 715) (SEQ. ID NO: 725) GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 716) (SEQ. ID NO: 726) GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 717) (SEQ. ID NO: 727) GGA GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 718) (SEQ. ID NO: 728) GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 719) (SEQ. ID NO: 729) GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 720) (SEQ. ID NO: 730) GGA GGG CGG CAT GGC GGG CAC AGG (FRAG 721) (SEQ. ID NO: 731) GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 722) (SEQ. ID NO: 732) GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 723) (SEQ. ID NO: 733) GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 724) (SEQ. ID NO: 734) GGA GGG CGG CAT GGC GGG CA-3' (FRAG 725) (SEQ. ID NO: 735) 132 GGA GGG CGG CAT GGC GGG C-3' (FRAG 726) (SEQ. ID NO: 736) GGA GGG CGG CAT GGC GGG (FRAG 727) (SEQ. ID NO: 737) GGA GGG CGG CAT GGC GG-3' (FRAG 728) (SEQ. ID NO: 738) GGA GGG CGG CAT GGC G-3' (FRAG 729) (SEQ. ID NO: 739) GGA GGG CGG CAT GGC (FRAG 730) (SEQ. ID NO: 740) GGA GGG CGG CAT GG -3'(FRAG 731) (SEQ. ID NO: 741) GGA GGG CGG CAT G (FRAG 732) (SEQ. ID NO: 742) GGA GGG CGG CAT (FRAG 733) (SEQ. ID NO: 743) GGA GGG CGG CA-3' (FRAG 734) (SEQ. ID NO: 744) GGA GGG CGG C-3'(FRAG 735) (SEQ. ID NO: 745) GA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 736) (SEQ. ID NO: 746) GA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 737) (SEQ. ID NO: 747) GA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 738) (SEQ. ID NO: 748) GA GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 739) (SEQ. ID NO: 749) GA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 740) (SEQ. ID NO: 750) GA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 741) (SEQ. ID NO: 751) GA GGG CGG CAT GGC GGG CAC AGG (FRAG 742) (SEQ. ID NO: 752) GA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 743) (SEQ. ID NO: 753) GA GGG CGG CAT GGC GGG CAC A-3' (FRAG 744) (SEQ. ID NO: 754) GA GGG CGG CAT GGC GGG CAC-3'(FRAG 745) (SEQ. ID NO: 755) GA GGG CGG CAT GGC GGG CA-3' (FRAG 746) (SEQ. ID NO: 756) GA GGG CGG CAT GGC GGG C-3' (FRAG 747) (SEQ. ID NO: 757) GA GGG CGG CAT GGC GGG (FRAG 748) (SEQ. ID NO: 758) GA GGG CGG CAT GGC GG-3'(FRAG 749) (SEQ. ID NO: 759) GA GGG CGG CAT GGC G-3' (FRAG 750) (SEQ. ID NO: 760) GA GGG CGG CAT GGC (FRAG 751) (SEQ. ID NO: 761) GA GGG CGG CAT GG (FRAG 752) (SEQ. ID NO: 762) GA GGG CGG CAT G (FRAG 753) (SEQ. ID NO: 763) GA GGG CGG CAT (FRAG 754) (SEQ. ID NO: 764) GA GGG CGG CA-3' (FRAG 755) (SEQ. ID NO: 765) A GGG CGG CAT GGC GGG CAC AGG CTG GGC-3'(FRAG 756) (SEQ. ID NO: 766) A GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 757) (SEQ. ID NO: 767) A GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 758) (SEQ. ID NO: 768) A GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 759) (SEQ. ID NO: 769) A GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 760) (SEQ. ID NO: 770) A GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 761) (SEQ. ID NO: 771) A GGG CGG CAT GGC GGG CAC AGG (FRAG 762) (SEQ. ID NO: 772) A GGG CGG CAT GGC GGG CAC AG-3' (FRAG 763) (SEQ. ID NO: 773) A GGG CGG CAT GGC GGG CAC A-3' (FRAG 764) (SEQ. ID NO: 774) A GGG CGG CAT GGC GGG CAC-3' (FRAG 765) (SEQ. ID NO: 775) A GGG CGG CAT GGC GGG CA-3' (FRAG 766) (SEQ. ID NO: 776) A GGG CGG CAT GGC GGG C-3'(FRAG 767) (SEQ. ID NO: 777) A GGG CGG CAT GGC GGG (FRAG 768) (SEQ. ID NO: 778) A GGG CGG CAT GGC GG-3' (FRAG 769) (SEQ. ID NO: 779) A GGG CGG CAT GGC G-3' (FRAG 770) (SEQ. ID NO: 780) A GGG CGG CAT GGC (FRAG 771) (SEQ. ID NO: 781) A GGG CGG CAT GG (FRAG 772) (SEQ. ID NO: 782) A GGG CGG CAT G (FRAG 773) (SEQ. ID NO: 783) A GGG CGG CAT (FRAG 774) (SEQ. ID NO: 784) GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 775) (SEQ. ID NO: 785) GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 776) (SEQ. ID NO: 786) GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 777) (SEQ. ID NO: 787) GGG CGG CAT GGC GGG CAC AGG CTG (FRAG 778) (SEQ. ID NO: 788) GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 779) (SEQ. ID NO: 789) GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 780) (SEQ. ID NO: 790) GGG CGG CAT GGC GGG CAC AGG (FRAG 781) (SEQ. ID NO: 791) GGG CGG CAT GGC GGG CAC AG-3' (FRAG 782) (SEQ. ID NO: 792) GGG CGG CAT GGC GGG CAC A-3' (FRAG 783) (SEQ. ID NO: 793) GGG CGG CAT GGC GGG CAC-3' (FRAG 784) (SEQ. ID NO: 794) GGG CGG CAT GGC GGG CA-3' (FRAG 785) (SEQ. ID NO: 795) GGG CGG CAT GGC GGG C-3' (FRAG 786) (SEQ. ID NO: 796) GGG CGG CAT GGC GGG (FRAG 787) (SEQ. ID NO: 797) GGG CGG CAT GGC GG-3' (FRAG 788) (SEQ. ID NO: 798) GGG CGG CAT GGC G-3' (FRAG 789) (SEQ. ID NO: 799) GGG CGG CAT GGC (FRAG 790) (SEQ. ID NO: 800) GGG CGG CAT GG (FRAG 791) (SEQ. ID NO: 801) GGG CGG CAT G (FRAG 792) (SEQ. ID NO: 802) 133 GG CGG CAT GGC GGG CAC AG G CTG GGC-3' (FRAG 793) (SEQ. ID NO: 803) GG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 794) (SEQ. ID NO: 804) GG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 795) (SEQ. ID NO: 805) GG CGG CAT GGC GGG CAC AGG CTG (FRAG 796) (SEQ. ID NO: 806) GG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 797) (SEQ. ID NO: 807) GG CGG CAT GGC GGG CAC AGG C-3' (FRAG 798) (SEQ. ID NO: 808) GG CGG CAT GGC GGG CAC AGG (FRAG 799) (SEQ. ID NO: 809) GG CGG CAT GGC GGG CAC AG-3' (FRAG 800) (SEQ. ID NO: 810) GG CGG CAT GGC GGG CAC A-3' (FRAG 801) (SEQ. ID NO: 811) GG CGG CAT GGC GGG CAC-3' (FRAG 802) (SEQ. ID NO: 812) GG CGG CAT GGC GGG CA-3'(FRAG 803) (SEQ. ID NO: 813) GG CGG CAT GGC GGG C-3' (FRAG 804) (SEQ. ID NO: 814) GG CGG CAT GGC GGG (FRAG 805) (SEQ. ID NO: 815) GG CGG CAT GGC GG-3' (FRAG 806) (SEQ. ID NO: 816) GG CGG CAT GGC G-3' (FRAG 807) (SEQ. ID NO: 817) GG CGG CAT GGC (FRAG 808) (SEQ. ID NO: 818) GG CGG CAT GG (FRAG 809) (SEQ. ID NO: 819) G CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 810) (SEQ. ID NO: 820) G CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 811) (SEQ. ID NO: 821) G CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 812) (SEQ. ID NO: 822) G CGG CAT GGC GGG CAC AGG CTG (FRAG 813) (SEQ. ID NO: 823) G CGG CAT GGC GGG CAC AGG CT-3' (FRAG 814) (SEQ. ID NO: 824) G CGG CAT GGC GGG CAC AGG C-3' (FRAG 815) (SEQ. ID NO: 825) G CGG CAT GGC GGG CAC AGG (FRAG 816) (SEQ. ID NO: 826) G CGG CAT GGC GGG CAC AG-3' (FRAG 817) (SEQ. ID NO: 827) G CGG CAT GGC GGG CAC A-3' (FRAG 818) (SEQ. ID NO: 828) G CGG CAT GGC GGG CAC-3' (FRAG 819) (SEQ. ID NO: 829) G CGG CAT GGC GGG CA-3' (FRAG 820) (SEQ. ID NO: 830) G CGG CAT GGC GGG C-3' (FRAG 821) (SEQ. ID NO: 831) G CGG CAT GGC GGG (FRAG 822) (SEQ. ID NO: 832) G CGG CAT GGC GG-3' (FRAG 823) (SEQ. ID NO: 833) G CGG CAT GGC G-3' (FRAG 824) (SEQ. ID NO: 834) G CGG CAT GGC (FRAG 825) (SEQ. ID NO: 835) CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 826) (SEQ. ID NO: 836) CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 827) (SEQ. ID NO: 837) CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 828) (SEQ. ID NO: 838) CGG CAT GGC GGG CAC AGG CTG (FRAG 829) (SEQ. ID NO: 839) CGG CAT GGC GGG CAC AGG CT-3' (FRAG 830) (SEQ. ID NO: 840) CGG CAT GGC GGG CAC AGG C-3' (FRAG 831) (SEQ. ID NO: 841) CGG CAT GGC GGG CAC AGG (FRAG 832) (SEQ. ID NO: 842) CGG CAT GGC GGG CAC AG-3' (FRAG 833) (SEQ. ID NO: 843) CGG CAT GGC GGG CAC A-3' (FRAG 834) (SEQ. ID NO: 844) CGG CAT GGC GGG CAC-3' (FRAG 835) (SEQ. ID NO: 845) CGG CAT GGC GGG CA-3' (FRAG 836) (SEQ. ID NO: 846) CGG CAT GGC GGG C-3' (FRAG 837) (SEQ. ID NO: 847) CGG CAT GGC GGG (FRAG 838) (SEQ. ID NO: 848) CGG CAT GGC GG-3' (FRAG 839) (SEQ. ID NO: 849) CGG CAT GGC G-3' (FRAG 840) (SEQ. ID NO: 850) GG CAT GGC GGG CAC AGG C TG GGC-3' (FRAG 841) (SEQ. ID NO: 851) GG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 842) (SEQ. ID NO: 852) GG CAT GGC GGG CAC AGG CTG G-3' (FRAG 843) (SEQ. ID NO: 853) GG CAT GGC GGG CAC AGG CTG (FRAG 844) (SEQ. ID NO: 854) GG CAT GGC GGG CAC AGG CT-3' (FRAG 845) (SEQ. ID NO: 855) GG CAT GGC GGG CAC AGG C-3' (FRAG 846) (SEQ. ID NO: 856) GG CAT GGC GGG CAC AGG (FRAG 847) (SEQ. ID NO: 857) GG CAT GGC GGG CAC AG-3' (FRAG 848) (SEQ. ID NO: 858) GG CAT GGC GGG CAC A-3' (FRAG 849) (SEQ. ID NO: 859) GG CAT GGC GGG CAC-3' (FRAG 850) (SEQ. ID NO: 860) GG CAT GGC GGG CA-3' (FRAG 851) (SEQ. ID NO: 861) GG CAT GGC GGG C-3' (FRAG 852) (SEQ. ID NO: 862) GG CAT GGC GGG (FRAG 853) (SEQ. ID NO: 863) GG CAT GGC GG-3' (FRAG 854) (SEQ. ID NO: 864) G CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 855) (SEQ. ID NO: 865) G CAT GGC GGG CAC AGG CTG GG-3' (FRAG 856) (SEQ. ID NO: 866) G CAT GGC GGG CAC AGG CTG G-3' (FRAG 857) (SEQ. ID NO: 867) G CAT GGC GGG CAC AGG CTG (FRAG 858) (SEQ. ID NO: 868) G CAT GGC GGG CAC AGG CT-3' (FRAG 859) (SEQ. ID NO: 869) 134 G CAT GGC GGG CAC AGG C-3' (FRAG 860) (SEQ. ID NO: 870) G CAT GGC GGG CAC AGG (FRAG 861) (SEQ. ID NO: 871) G CAT GGC GGG CAC AG-3' (FRAG 862) (SEQ. ID NO: 872) G CAT GGC GGG CAC A-3' (FRAG 863) (SEQ. ID NO: 873) G CAT GGC GGG CAC-3' (FRAG 864) (SEQ. ID NO: 874) G CAT GGC GGG CA-3' (FRAG 865) (SEQ. ID NO: 875) G CAT GGC GGG C-3'(FRAG 866) (SEQ. ID NO: 876) G CAT GGC GGG -3'(FRAG 867) (SEQ. ID NO: 877) CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 868) (SEQ. ID NO: 878) CAT GGC GGG CAC AGG CTG GG-3' (FRAG 869) (SEQ. ID NO: 879) CAT GGC GGG CAC AGG CTG G-3' (FRAG 870) (SEQ. ID NO: 880) CAT GGC GGG CAC AGG CTG (FRAG 871) (SEQ. ID NO: 881) CAT GGC GGG CAC AGG CT-3' (FRAG 872) (SEQ. ID NO: 882) CAT GGC GGG CAC AGG C-3' (FRAG 873) (SEQ. ID NO: 883) CAT GGC GGG CAC AGG -3'(FRAG 874) (SEQ. ID NO: 884) CAT GGC GGG CAC AG-3' (FRAG 875) (SEQ. ID NO: 885) CAT GGC GGG CAC A-3' (FRAG 876) (SEQ. ID NO: 886) CAT GGC GGG CAC-3' (FRAG 877) (SEQ. ID NO: 887) CAT GGC GGG CA-3' (FRAG 878) (SEQ. ID NO: 888) CAT GGC GGG C-3' (FRAG 879) (SEQ. ID NO: 889) AT GGC GGG CAC AGG CTG GGC-3' (FRAG 880) (SEQ. ID NO: 890) AT GGC GGG CAC AGG CTG GG-3' (FRAG 881) (SEQ. ID NO: 891) AT GGC GGG CAC AGG CTG G-3' (FRAG 882) (SEQ. ID NO: 892) AT GGC GGG CAC AGG CTG (FRAG 883) (SEQ. ID NO: 893) AT GGC GGG CAC AGG CT-3' (FRAG 884) (SEQ. ID NO: 894) AT GGC GGG CAC AGG C-3' (FRAG 885) (SEQ. ID NO: 895) AT GGC GGG CAC AGG (FRAG 886) (SEQ. ID NO: 896) AT GGC GGG CAC AG-3' (FRAG 887) (SEQ. ID NO: 897) AT GGC GGG CAC A-3' (FRAG 888) (SEQ. ID NO: 898) AT GGC GGG CAC-3' (FRAG 889) (SEQ. ID NO: 899) AT GGC GGG CA-3' (FRAG 890) (SEQ. ID NO: 900) T GGC GGG CAC AGG CTG GGC-3' (FRAG 891) (SEQ. ID NO: 901) T GGC GGG CAC AGG CTG GG-3' (FRAG 892) (SEQ. ID NO: 902) T GGC GGG CAC AGG CTG G-3' (FRAG 893) (SEQ. ID NO: 903) T GGC GGG CAC AGG CTG (FRAG 894) (SEQ. ID NO: 904) T GGC GGG CAC AGG CT-3' (FRAG 895) (SEQ. ID NO: 905) T GGC GGG CAC AGG C-3' (FRAG 896) (SEQ. ID NO: 906) T GGC GGG CAC AGG (FRAG 897) (SEQ. ID NO: 907) T GGC GGG CAC AG-3' (FRAG 898) (SEQ. ID NO: 908) T GGC GGG CAC A-3' (FRAG 899) (SEQ. ID NO: 909) T GGC GGG CAC-3' (FRAG 900) (SEQ. ID NO: 910) GGC GGG CAC AGG CTG GGC-3' (FRAG 901) (SEQ. ID NO: 911) GGC GGG CAC AGG CTG GG-3' (FRAG 902) (SEQ. ID NO: 912) GGC GGG CAC AGG CTG G-3' (FRAG 903) (SEQ. ID NO: 913) GGC GGG CAC AGG CTG (FRAG 904) (SEQ. ID NO: 914) GGC GGG CAC AGG CT-3' (FRAG 905) (SEQ. ID NO: 915) GGC GGG CAC AGG C-3' (FRAG 906) (SEQ. ID NO: 916) GGC GGG CAC AGG (FRAG 907) (SEQ. ID NO: 917) GGC GGG CAC AG-3'(FRAG 908) (SEQ. ID NO: 918) GGC GGG CAC A-3' (FRAG 909) (SEQ. ID NO: 919) GC GGG CAC AGG CTG GGC-3' (FRAG 910) (SEQ. ID NO: 920) GC GGG CAC AGG CTG GG-3'(FRAG 911) (SEQ. ID NO: 921) GC GGG CAC AGG CTG G-3' (FRAG 912) (SEQ. ID NO: 922) GC GGG CAC AGG CTG (FRAG 913) (SEQ. ID NO: 923) GC GGG CAC AGG CT-3' (FRAG 914) (SEQ. ID NO: 924) GC GGG CAC AGG C-3' (FRAG 915) (SEQ. ID NO: 925) GC GGG CAC AGG (FRAG 916) (SEQ. ID NO: 926) GC GGG CAC AG-3' (FRAG 917) (SEQ. ID NO: 927) C GGG CAC AGG CTG GGC-3' (FRAG 918) (SEQ. ID NO: 928) GGG CAC AGG CTG GG-3' (FRAG 919) (SEQ. ID NO: 929) C GGG CAC AGG CTG G-3' (FRAG 920) (SEQ. ID NO: 930) C GGG CAC AGG CTG (FRAG 921) (SEQ. ID NO: 931) C GGG CAC AGG CT-3' (FRAG 922) (SEQ. ID NO: 932) C GGG CAC AGG C-3' (FRAG 923) (SEQ. ID NO: 933) C GGG CAC AGG (FRAG 924) (SEQ. ID NO: 934) GGG CAC AGG CTG GGC-3' (FRAG 925) (SEQ. ID NO: 935) GGG CAC AGG CTG GG-3'(FRAG 926) (SEQ. ID NO: 936) 135 GOG CAC AGO GTG G-3' (FRAG 927) (SEQ. ID NO: 937) GGG CAG AGG CG (FRAG 928) (SEQ. ID NO: 938) GOG CAC AGO CT-3' (FRAG 929) (SEQ. ID NO: 939) GGG GAG AGO C-3- (FRAG 930) (SEQ. ID NO: 940) GO GAG AGG GTG GGC-3' (FRAG 931) (SEQ. ID NO: 941) 00 GAG AGG GTG GG-3' (FRAG 932) (SEQ. ID NO: 942) GG GAG AGG GTG 0-3- (FRAG 933) (SEQ. ID NO: 943) GAG AGG CG (FRAG 934) (SEQ. ID NO: 944) 00 GAG AGG GT-3' (FRAG 935) (SEQ. ID NO: 945) 5'-G GAG AGO GTG GGG-3' (FRAG 936) (SEQ. ID NO: 946) GAG AGO GTG 00-3' (FRAG 937) (SEQ. ID NO: 947) GAG AGO GTG 0-3' (FRAG 938) (SEQ. ID NO: 948) GAG AGO GIG (FRAG 939) (SEQ. ID NO: 949) AOO CG GG-3' (FRAG 940) (SEQ. ID NO: 950) 5'-GAG AGO GTG 00-3' (FRAG 941) (SEQ. ID NO: 951) AGO CG 0-3' (FRAG 942) (SEQ. ID NO: 952) AOO CG GG-3' (FRAG 943) (SEQ. ID NO: 953) AGO GTG, 00-3' (FRAG 944) (SEQ. ID NO: 954) AGO CG GG-3' (FRAG 945) (SEQ. ID NO: 955) S'-Tf- TGG T-rG GC7 TOT GTG TGT TG (FRAG 946) (SEQ. ID NO: 956) GGG GG TG GTG (FRAG 947) (SEQ. ID NO: 957) GG GT GO GI GIG G GTG GGG OT (FRAG 948) (SEQ. ID NO: 958) CGGC C GGG 00 0 TG (FRAG 949) (SEQ. ID NO: 959) S'-TOG TG GT TOO GIG GGG (FRAG 950) (SEQ. ID NO: 960) 5'-GTT GIG CGG GIG GGG GO (FRAG 951) (SEQ. ID NO: 961) S*-TOG TOG OCT TOT OG (FRAG 952) (SEQ. ID NO: 962) GIG TGT TGT 000 (FRAG 953) (SEQ. ID NO: 963) GOT GGG ICGT (FRAG 954) (SEQ. ID NO: 964) GG TGG TGT G (FRAG 955) (SEQ. ID NO: 965) 5'-OCT TOG TGG TOO GG TG (FRAG 956) (SEQ. ID NO: 966) TGT GGT GTG GYT (FRAG 957) (SEQ. ID NO: 967) Human Adenosine A2a Receptor Nucleic Acid and Antisense Oligonucleotide Fragments TTT IGI TFIT GIG GG GTG TOT GOT CG TTT TTT TGT 0 GG GTG GIG 000 GG TGT GG GGG GGG GG GTG GGT GGG GOBOGB G BT 00 GBT GGG OT G F GGG GTGrCTGC GYT TOG GIG GGG TG CG GIGCC GG GO G GT OG00 GG GT TO GG CG TOT TGG GCT 000 -GGG TOG GG TGG GT-l GTG TG GGG GTT GTT GI00 GGCT G TG TG TG TOG TG TOT GG GGG GOTA GAG GGA OGA GG GAT OAT 000 GAT GGG AGA GAG GAG AGO, G GIB GBG GB GOB GGG CBT OBT 000 GBT GG BGB GBCGOBG BOO G-31 (FRAG. NO. 1665) (SEQ. ID NO:1680) 5*-CG GG GTG-3D (FRAG 1666) (SEQ. ID NO: 1681) TIT TGT TTT CGGOGC GTG-3U (FRAG 958) (SEQ. ID NO: 968) SDR-TOT GOT CG T T U-T TGT G-3Di (FRAG 959) (SEQ. ID NO: 969) IG GG0G GI GG C-30 (FRAG 960) (SEQ. ID NO: 970) GG CG GIG GI GGG-30 (FRAG 961) (SEQ. ID NO: 971) SD-GOB GGG 13 GBT BI 00 BT GGG-3D (FRAG 962) (SEQ. ID NO: 972) SD-OTO GilT CIT GGG GIG GT-l TOG GIG-3D (FRAG 963) (SEQ. ID NO: 973) TG CG GIG GCGG O-3D (FRAG 964) (SEQ. ID NO: 974) GGG GOT GG GT 10-3Di (FRAG 965) (SEQ. ID NO: 975) 51]-GGC GGG TOT TGG GGT 000-3D (FRAG 966) (SEQ. ID NO: 976) 5-OGGC TOO GG TGG GTl GIG TG-31i (FRAG 967) (SEQ. ID NO: 977) SD-OGG GT-l CT- GI GOG GGT G-3D (FRAG 968) (SEQ. ID NO: 978) 51D-TG TG TG TOO TG TOT GG GGG G-30 (FRAG 969) (SEQ. ID NO: 979) S'-OTAGACGAGOAGGGATGATGGGATGGCAGAAGAGAGGG-3' (FRAG 970) (SEQ. ID NO: 980) S'-GTBCGBGGBGOGGBTGGOGBIOGGCBGBBGBGBOG-3- (FRAC 971) (SEQ. ID NO: 981) Human Adenosine A2b Receptor Nucleic Acid Antisense Otigonucleotide Fragments S'-GG GGG GTG GGG GT GUT GOT OG GG 00 OTT G G OG GG 00 GGG GIG C GG TGG G~r GG G G GGG0 GGG GIGCT GG TGG GG GIG00 GGG GGCC GG GOC CG TG GGG O00 GG 00GG TG TOG CG 0GG OG GIG GO GIG G GU TO OTG 000GGC CGG GG C GG GT GGG GIG UTG GIG 000 IGG GGG 10 AGA GG G TGTG 10 IGGA GA GA TOO CGG GOG GAOG OG GGG C BGB GG GT GG 010GI GGB GB 0GB TOG CG00B G ICCGCG GG GGG GGGAGCGGGO AGGTGAGAA GGGAGGO GAGGGGGT GCGGGGGTA IOGGGCATOGG CGOGGGI GAGGGGG GGGGTGGGG GGGGGUT CGTAGOGGO CGGGGGGG GGAGTGOGG GGGATGI GCTGGAGAGA GAGGAGG IGIAGTOG 136

GCTGGAGCTG

AACACTCTGC

TCGCCATCCC

CTGCTTCGTG

GCCATCTGTG

TCTGGGTCCT

CAACTGCACA

GTGGTCCCCA

TGGTGATCTA

GTCATCGCCG

AGACGCCCAC

CMTGCCATC

CTGGTGCTCA

TCCCGCTCAG

TGCCTT[GGC

GAACCCTGGG

TGAGCTACAT

CATTAAGATC

CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC ACCATCAGCC TGGGCT-FCTG CACTGAC1TC TACGGCTGCC CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG TTCCTGGTGG CCTGCAGGCA GC117CAGCGC ACTGAGCTGA

GTGGGGCTCT

TCTTCCTCGC

CAGATACCTG

ATTGCTGTCC

GTGCCACCAA

CTTTGAGAAT

C'FrATAATGC

TGGACCACTC

GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TrGTGGGGAT TITTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA

AGTGGGCAAT

CCGGAACCGA

AAGAGTGGGA

TITCCAGGAGA

CACCTCACAA

ATGTGTCAGT

TTATGCCAAC

AAATTACTGA

CAATGGAAAA

AAAGTATAAT

GCGGATCACG

GCCGCCACCA

CGAGTGGGTG

CGGGGGGCCC

GCGCGGTCCG

TAGGGGGCGC

GGAGCTGGTC

ACTCTGCAGA

CCATCcccTFr CTJ7CGTGCTG

ATCTGTGTCC

GGGTCCTTGC

CTGCACAGAA

GTCCCCATGA

TGATCTACAT

GACCACCCTC

TGGTTFACCTG

GGGCAATGAA

GAACCGAGAC

AGTGGGAATG

CAGGAGAAGA

CTCACAAGGA

TGTCAGTAGT

ATGCCAACAG

ATTACTGAAA

ATGGAAAAAT

GAGGCGCGGT

CGGTAGGGGG

GAATATGGCC

GACTTCCGCT

ATGGTCAGGC

ATTCTTCTGT CACATGCCAA TTCAGTTGTC ACACTYITTCA CAAAATrATC TCCAGGTATC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT AGATACAAAT CCACAAGAAA GGAAATGGAC TGCCTCTCTr AGTAGCACCA AGGATTGACA AGCTTGAATG GATITCTAACA AACTAITTA CTGTGAAACA ATAAAAGTTG ACTGTACTAA CAAAGAGGAC ACGGCTGGTT GAGCACTTCC CTGGAGCTAC AATATATI'TA TGATCTATTC GACTCTTTTG TT1TAAAAG GTGTGAACTA TTATAATGCA AAATGTATAC TTGTTGCCAG AATCCCATTG TCTATGCTTA TTCTCTGCCA AGCAGATGTC ATGATCTAGG CTCTCGCCTC TTCATTGTGA AAGATAGCTA CACGTATCTA GCTAATATGT AGCTGCTTTT ACTGTGTGGA TCTGCCTTGT TTATGGTGGA AATACT=I AACTTAGAGG GAAGGTGACC TCAAAAATTA ACTYJTGGGAG GCCAAGGCAG GGGCAATTTG TTAGTTATCC GCGCGAACTT TGGGCTCGGG TGGGTGCCGC CTCTTGGCCG TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC AGGTCAGGAG YJ7CAAAACCA GCCTGTCCAA TATAGTG AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC CGCCCACCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG TGCCATCACC ATCAGCCTGG GCYFCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG GTGCTCACGC AGAGCTCCAT CITCAGCCT[ CTGGCCGTGG CAGTCGACAG ATACCTGGCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATf GCTGTCCTCT CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCTT TGAGAATGTG GCTACATGGT ATATTTCAAT TTrCTTTGGGT GTGTTrCTGCC CCCACTGCTT ATAATGCTGG TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCCTGTGC TGCATGCTGT TAACTGTGTC ACTCTTTrTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG TTCCGCTACA C1TrTCACAA AATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTrC TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTTTTC ATITGTGAAAG ATAGCTACAC AATGGACTGC CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG AGGCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTU'AC TGTGTGGATT CTTGAATGGA 7FrCTAACAGA CTCTrTTGTT TTTAAAAGTC TGCCTTGTTT ATGGTGGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGCA AAAAGTTGAC TGTACTAAAA ATG CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG, AACACTCTGC AGACGCCCAC CAACTACTrC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGOCTCT TCGCCATCCC CTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTITCCTCGC CTGCTITCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC C17CTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTG;CCACCAA CAACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTITI7GAGAAT GTGGTCCCCA TGAGCTACAT GGTATATI1TC AAT-rTCTTTG GGTGTGT-rCT GCCCCCACTG CTI7ATAATGC TGGTGATCTA CATTAAGATC TT1CCTGGTGG CCTGCAGGCA GCTTCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGTGGGGAT TITGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTCTTr TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTrCTJ7CTGT CACATGCCAA TTCAGTTGTC AATCCCA'I1TG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACAC'IICA CAAAATTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA 137

CACCTCACAA

ATGTGTCAGT

TTATGCCAAC

AAATTACTGA

CAATGGAAAA

AAAGTATAAT

GCGGATCACG

GCCGCCACCA

CGAGTGGGTG

CGGGGGGCCC

GCGCGGTCCG

TAGGGGGCGC

GGAGCTGGTC

ACTCTGCAGA

CCATCCCCT-r

CTTCGTGCTG

ATCTGTGTCC

GGGTCCTTGC

CTGCACAGAA

GTCCCCATGA

TGATCTACAT

GACCACCCTC

TGGTTrACCTG

GGGCAATGAA

GAACCGAGAC

AGTGGGAATG

CAGGAGAAGA

CTCACAAGGA

TGTCAGTAGT

ATGCCAACAG

ATTACTGAAA

GGAAATGGAC TGCCTCTCTT AGTAGCACCA AGGATTGACA AGCTTGAATG GATTCTAACA AACTATrA CTGTGAAACA ATAAAAGTTG ACTGTACTAA TATTCGGCCG GGCATGGTGG AGGTCAGGAG TTCAAAACC AGACGCGGCA CGGCGCCTGG GAGCACTTCC CTGGAGCTAC CACGTATCTA GCTAATATGT AATATAUTTA TGATCTAUTC AGCTGCTTTT ACTGTGTGGA GACTCTTT7G TYFITAAAAG TCTGCCTTGT TTATGGTGGA GTGTGAACTA TTATAATGCA AATACTTrTTT AACTTAGAGG AAATGTATAC TTGTrGCCAG GAAGGTGACC TCAAAAATTA CTCACACCTG TAAUTCCAGC ACTTTrGGGAG GCCAAGGCAG A GCCTGTCCAA TATAGTG GGGCAATrTG TTAGFJTATCC ACCGGAGGGG CCCCGCGCGG GCGCGAACTr TGGGCTCGGG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT OGAGACACAG GACGCGCTGT ATCGCCGCGC TTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CGCCCACCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG TGCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTTCTAC GGCTGCCTCT GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT C1TGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCTT GCTACATGGT ATATTTCAAT TTCTTTGGGT GTGT-TCTGCC CCCACTGCTT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATT-T TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT

CTCTTGGCCG

GCAGGCGGAG

GCGCCTTCGG

ACGTGGCGCT

CACGGCGAAC

GGGCTCTTCG

TCCTCGCCTG

ATACCTGGCC

GCTGTCCTCT

CCACCAACAA

TGAGAATGTG

ATAATGCTGG

ACCACTCGAG

TGCCCTGTGC

AAGCCCAAGT

TATGGCCATT

TTCCGCTACA

GTCAGGCTGG

TACAAATCCA

AATGGACTGC

AGGCTCCAAG

CTTGAATGGA

CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG C1TM7CACAA AATTFATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG GGTACAGCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAAGAAACAA AGAGGACACO GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCTCTTGAG CACT[CCCTG GAGCTACCAC GTATCTAGCT AATATGTATG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT YI7CTAACAGA CTCTrTTGTT TU-AAAAGTC TGCCTTGTTT ATGGTGGAAA CTATTYJ7ACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTFFAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG (FRAG. NO: 1670) (SEQ. ID NO:3006) GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG

GCGCGAACTT

TGGGTGCCGC

CTCAGAAGCG

CTCGCCCGGC

GACGCGCTGT

CCGCGGTGGG

CGTGGCCGTG

GGCTGCCTCT

CAGTCGACAG

AGGGGTCATT

AAAGACAGTG

AGTGTCTCTT

CCCACTGCTT

GAGCTGATGG

TGGGGATTTTf

GGGTAAAAAT

CCCATTGTCT

TCTGCCAAGC

ATCTAGGCTC

ATTGTGAAAG

GTATCTAGCT

cTGcTTrTTAC TGCCTfGTTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA CTCTI'GGCCG CGGGGGGCCC CGACCCGTGG GTCCCGOCCA CCAGCGCCCC AGCCCCGAGG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG

ACGTGGCGCT

CACGGCGAAC

GGGCTCTTCG

TCCTCGCCTG

ATACCTGGCC

GCTGTCCTCT

CCACCAACAA

TGAGAATGTG

ATAATGCTGG

ACCACTCGAG

TGCCCTGTGC

AAGCCCAAGT

ATGCTTACCG

AGATGTCAAG

GGAGCTGGTC ATCGCCGCGC TFJTCGGTGGC ACTCTGCAGA CGCCCACCAA CTACTTCCTG CCATCCCCTT TGCCATCACC ATCAGCCTGG CTTCGTGCTG GTGCTCACGC AGAGCTCCAT ATCTGTGTCC CGCTCAGGTA TAAAAGTfG GGGTCC11TGC CTTTrGGCATC GGATTGACTC CTGCACAGAA CCCTGGGATG GAACCACGAA GTCCCCATGA GCTACATGGT ATAT1TCAAT TGATCTACAT TAAGATCTTC CTGGTGGCCT GACCACCCTC CAGCGGGAGA TCCATGCAGC TGGTTACCTG TGCATGCTGT TAACTGTGTC GGGCAATGAA TATGGCCATT CTTCTGTCAC GAACCGAGAC TTCCGCTACA CTTTTCACAA AGTGGGAATG GTCAGGCTGG GGTACAGCCT

CCATGCTGCT

GGGCAACGTG

GTGTCCCTGG

GCTTCTGCAC

CTTCAGCC117 G3TCACGGGGA

CATTCCTGGG

GGAGACACAG

CTGGTGTGCG

CTGCGGCCGA

TGACTTCTAC

CTGGCCGTGG

CCCGAGCAAG

GTGGAACAGT

TGAAAGCTGC TGCCTTGTGA TrC1TrGGGT GTGYrCTGCC GCAGGCAGCT TCAGCGCACT

CAAGTCACTG

ACTCTTT"TCC

ATGCCAAT-rC

AATTATCTCC

GCTCTCGGTG

AGAGGACACG

CACTTCCCTG

TATATfTATG CTCTM~GT-r

GCCATGATTG

AGCCAGCTCA

AG'FrGTCAAT

AGGTATCTTC

TGGGCCTATG

GCTGGYTTMC

GAGCTACCAC

ATCTATTCAG

TT-rAAAAGTC TCGCCTCTTJC CAGGAGAAGA TACAAATCCA CAAGAAACAA ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG AATATGTATG TGTCAGTAGT AGGCTCCAAG GA~rGACAAA TGTGTGGATr ATGCCAACAG CTTGAATGGA TTCTAACAGA ATGGTGGAAA ATrACTGAAA CTATYITACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTTT-rTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG-3'(FRAG.NO:_ySEQ.IID NO:2436) AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CG*JCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCT-r CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC C'rrGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCYITCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCYJ7CAGC CYrCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG 138 GGACCCGAGC AAGAGGGGTC AT-rGCTGTCC TCTGGGTCCT TGCCTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA

TGCTGCCTTG

GGTGTGTFrCT

GCTTCAGCGC

CTGGCCATGA

TCCAGCCAGC

TTCAGTTGTC

TCCAGGTATC

GTGTGGGCCT

ACGGCTGGTT

CTGGAGCTAC

TGATCTATTC

TITTTAAAAG

YJ7ATAATGCA TrGTTGCCAG

TAATTCCAGC

TGAAGTGTCT

GCCCCCACTG

ACTGAGCTGA

TTGTGGGGAT

TCAGGGTAAA

AATCCCATTG

TYFCTCTGCCA

ATGATCTAGG

TTCATTGTGA

CACGTATCTA

AGCTGCT-FTT

TCTGCCTTGT

AATACTTTITT

GTGCCACCAA

CTTTGAGAAT

CTTATAATGC

TGGACCACTC

TT1TTGCCCTG

AATAAGCCCA

TCTATGCTTA

4GCAGATGTC

CTCTCGCCTC

AAGATAGCTA

GCTAATATGT

ACTGTGTGGA

TTATGGTGGA

AACTTAGAGG

CAACTGCACA

GTGGTCCCCA

TGGTGATCTA

GAGGACCACC

TGCTGGTTAC

AGTGGGCAAT

CCGGAACCGA

AAGAGTGGGA

TTCCAGGAGA

CACCTCACAA

ATGTGTCAGT

TTATGCCAAC

AAATTACTGA

CAATGGAAAA

AAAGTATAAT

GCGGATCACG

GAACCCTGGG ATGGAACCAC GAATGAAAGC

TGAGCTACAT

CAUrAAGATC

CTCCAGCGGG

CTGTGCATGC

GAATATGGCC

GACTTCCGCT

ATGGTCAGGC

GGTATATTfTC AATT1TCTTTG TTCCTGGTGG CCTGCAGGCA AGATCCATGC AGCCAAGTCA TGTTAACTGT GTCACTC1TT ATTCTJTCTGT CACATGCCAA ACACTI7TTCA CAAAATTATC TGGGGTACAG CCTGCTCTCG AGATACAAAT CCACAAGAAA CAAAGAGGAC GGAAATGGAC TGCCTCTCTT GAGCACTTCC AGTAGCACCA AGGATTGACA AATATATTTA AGCYTGAATG GATFJCTAACA GACTCT=rG AAGTAUTTTA CTGTGAAACA GTGTGAACTA ATAAAAGTTG ACTGTACTAA AAATGTATAC TATTCGGCCG GGCATGGTGG CTCACACCTG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA GAAGGTGACC TCAAAAATTA ACTTTGGGAG GCCAAGGCAG TATAGTG (FRAG. (SEQ. ID NO:2435) GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA

TGGGTGCCGC

CTCAGAAGCG

CTCGCCCGGC

GACGCGCTGT

CCGCGGTGGG

CGTGGCCGTG

GGCTGCCTCT

CAGTCGACAG

AGGGGTCATT

AAAGACAGTG

AGTGTCTCTT

CCCACTGCTT

GAGCTGATGG

TGGGGATTTT

GGGTAAAAAT

CCCATTGTCT

TCTGCCAAGC

ATCTAGGCTC

ATTGTGAAAG

GTATCTAGCT

CTGCTTTTAC

TGCCTTGTTT

CTCTTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC GCGCCTTCGG TAGGGGGCGC

ACGTGGCGCT

CACGGCGAAC

GGGCTCTTCG

TCCTCGCCTG

ATACCTGGCC

GCTGTCCTCT

CCACCAACAA

TGAGAATGTG

ATAATGCTGG

ACCACTCGAG

TGCCCTGTGC

AAGCCCAAGT

ATGCTTACCG

AGATGTCAAG

GGAGCTGGTC

ACTCTGCAGA

CCATCCCCTr

CTTCGTGCTG

ATCTGTGTCC

GGGTCCTUGC

CTGCACAGAA

GTCCCCATGA

TGATCTACAT

GACCACCCTC

TGGTTACCTG

GGGCAATGAA

GAACCGAGAC

AGTGGGAATG

CCGGGGCCCA

ATCGCCGCGC

CGCGCACCAA

TGCCATCACC

GTGCTCACGC

CGCTCAGGTA

CTIrrGGCATC

CCCTGGGATG

GCTACATGGT

TAAGATCTTC

CAGCGGGAGA

TGCATGCTGT

TATGGCCATI

TTCCGCTACA

GTCAGGCTGG

GCTGGCCCGG CCATGCTGCT GOAGACACAG 'TTCGGTGGC GGGCAACGTG CTGGTGTGCG CTACTTCCTG GTGTCCCTGG CTGCGGCCGA ATCAGCCTGG GCTTCTGCAC TGACTTCTAC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG TAAAAGTTTG GTCACGGGGA CCCGAGCAAG GGATTGACTC CATTCCTGGG GTGGAACAGT GAACCACGAA TGAAAGCTGC TGCCTTGTGA ATATTTCAAT TCY[TGGGT GTGTTCTGCC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT

TCCATGCAGC

TAACTGTGTC

CTTCTGTCAC

CTTTTrCACAA

GGTACAGCCT

CAAGTCACTG GCCATGATTG ACTCTTTTCC AGCCAGCTCA ATGCCAATTFC AGTFGTCAAT AATTATCTCC AGGTATCTTC GCTCTCGGTG TGGGCCTATG AGAGGACACG GCTGGTTTTC CACTTCCCTG GAGCTACCAC TATATTrrATG ATCTAT7CAG CTCTTTTGTT TTTAAAAGTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA TGTGTGGATr ATGCCAACAG CTTGAATGGA TTCTAACAGA ATGGTGGAAA ATUACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG-3'(FRAG. NO:_J(SEQ.1nD NO:Z425) AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT

CACGCGGCTG

GCTGGAGACA

GTGCTGGTGT

TGGCTGCGGC

CACTGACTTC

CTJTCTGGCCG

GGACCCGAGC

GGGGTGGAAC

TGCTGCCTTG

GGTGTGT-rCT

GCTTCAGCGC

CTGGCCATGA

TCCAGCCAGC

TITCAGYI7GTC

TCCAGGTATC

GTGTGGGCCT

ACGGCTGGTT

CTGGAGCTAC

TGATCTATTC

T'FTAAAAG

CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CAGGACGCGC TGTACGTGGC GCTGGAGCTG GCGCCGCGGT GGGCACGGCG AACACTCTGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC TACGGCTGCC TCTrCCTCGC CTGCTTCGTG TGGCAGTCGA CAGATACCTG GCCATCTGTG AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT AGTAAAGACA GTGCCACCAA CAACTGCACA CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GTCATCGCCG CGCTTTCGGT GGCGGGCAAC AGACGCCCAC CAACTACTTC CTGGTGTCCC C1TTGCCATC ACCATCAGCC TGGGCTTCTG CTGGTGCTCA CGCAGAGCTC CATC'rrCAGC TCCCGCTCAG GTATAAAAGT 'rrGGTCACGG TGCCTITTGGC ATCGGATTGA CTCCATTCCT GAACCCTGGG ATGGAACCAC GAATGAAAGC

TGAAGTGTCT

GCCCCCACTG

ACTGAGCTGA

TJTGTGGGGAT

TCAGGGTAAA

AATCCCATG

TTCTCTGCCA

ATGATCTAGG

TTCATTGTGA

CACGTATCTA

AGCTGC'TTT

TCTGCCTTGT

CTTTGAGAAT

CTTATAATGC

TGGACCACTC

T'TGCCCTG

AATAAGCCCA

TCTATGCTTrA

AGCAGATGTC

CTCTCGCCTC

AAGATAGCTA

GCTAATATGT

ACTGTGTGGA

TTATGGTGGA

GTGGTCCCCA

TGGTGATCTA

GAGGACCACC

TGCTGGTTAC

AGTGGGCAAT

CCGGAACCGA

AAGAGTGGGA

TGAGCTACAT

CATTAAGATC

CTCCAGCGGG

CTGTGCATGC

GAATATGGCC

GACTrCCGCT

ATGGTCAGGC

GGTATATT-rC AATTTCTTTG TTCCTGGTGG CCTGCAGGCA AGATCCATGC AGCCAAGTCA TGT-rAACTGT GTCACTCTf ATTCTITCTGT CACATGCCAA ACACTIrCA CAAAATTATC TGGGGTACAG CCTGCTCTCG TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC CACCTCACAA GGAAATGGAC TGCCTCTCTr GAGCACTTCC ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATATA UTATGCCAAC AGCTrGAATG GATITCTAACA GACTC1TG AAATTACTGA AACTATrTTA CTGTGAAACA GTGTGAACTA 139 TITATAATOCA AATACTTTTT AACTTAGAGG CAATGGAAAA ATAAAAGTTO ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTOACC TCAAAAATrA AAAGTATAAT TATTCGGCCO GGCATGGTGG CTCACACCTG TAAT"fCCAGC ACITTTOOGAG GCCAAGGCAG GCOGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG (FRAG. NO: SEQ. ID NO: 2424) 5'-GCGCGTCCTG-3' (FRAG. NO: 1671) (SEQ. ID NO:1686) GGG CCC COG-3' (FRAG. NO: 1672) (SEQ. ID NO:1687) GTC GGG 0CC CCC C-3' (FRAG. NO: 1673) (SEQ. ID NO:1688) CGCC CGGG-3' (FRAG. NO: 1674) (SEQ. ID NO:1689) 515-GGCG0CC GTGCGCG CGT CTT GGT GOCGGC GG-39 (FRAG 972) (SEQ. ID NO: 982) 51A-GTTCGGCCCGGC GCG GGG CCC CTC CGG TCC-30 (FRAG 973) (SEQ. ID NO: 983) 51D-GTTCGGCC CGC GCGGGCCC CTCCOOGTCC-3' (FRAC 974) (SEQ. ID NO: 984) OTC GOG 0CC CCC CGC GOC C-31i (FRAG 975) (SEQ. ID NO: 985) TCGGGG0CTG GGG CGCTOGTGGCCG GO-3ii (FRAG 976) (SEQ. ID NO: 986) 51]-CCG CGCCTC CGC CTG CCG CTTCGIG-3iI (FRAG 977) (SEQ. ID NO: 987) 515-GCT GOG CCC CGG OCO CCC CCT-31l (FRAG 978) (SEQ. ID NO: 988) 51J-CCC CTC 7rrG CTC GGG TCC CCG TG-3D (FRAG 979) (SEQ. ID NO: 989) 5'-ACAGCGCGTCCTGTGTCTCCAGCAGCATOOCCGGOGCAGCTGGGCCCC-3- (FRAG 980) (SEQ. ID NO: 990) 5'-BCBGCGCGTCCTGTGTCTCCBGCBGCBTGGCCGGGCCBGCTGGGCCCC-3- (FRAG 981) (SEQ. ID NO: 991) Human Adenosine A3 Receptor Nucleic Acid and Antisense Oli2onucleotide Fragments S'-ACA GAG CAG TGC TGT TGT TOG GCA TCT TGC CTT CCC AGG G BCB OBO CB TOC TOT TOT TGG GCB TCT TG CTT CCC BOG GCC CTT TTC TGG TGO GGT GOT GCT OTT GTT GGG CTT TCT TCT GTT CCC BCB GBG CBG TGC TOT TOT TOG GCB TCT TOC CTT CCC BOG 0CC CTT TTC TOO TOO GOT GOT OCT OTT OTT 000 C TTf CTT CTG TTC CC GAATTCCCAG ATGGGCAOAO OTOOCTOGOC TOOTOACCCT AAOTGTOTCT CCTOCCTTTA TrCTCTCTAO TGOTTATTC TTTCATOTGO TATCT-rGCCT ACAOCATOCT GTO1T700AC ACAAACCCCT TTCCTTGOTT TCTCTOACCC AOCTOAOATG OACTOATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGOO GAGOGAGGOT TT-GCAGT ATTTAACTAA OGTTCAAAGA OTOCTATATA GTGAGAAAGG CTTCTITI= TrTTT1TTTTT TThTT7GCA OAGTGTGCC TCCTAOAAAT TTCTCTTOOT AACTTCCTTC TCTOAAGCAC AOATAAAOAA AACAATTACA OTAOAAACAT TTATOAOOGA CACATTOGAG GCCGATGAAG CT1TrCAAGT TCCAGCAGTO CAGOGATOTO GOCAGAACTG ACATTrGGAAA ATACTAOAAT GATOOAAATT GOACTOCCCT TTTTAATOTC TOOGGAGTCT OCTCAGGAO AAATGACAAG TCTOOCOGGG GATTTOGTAA OACTTGOATC AACTTOOGAT ACAGOOTOGO GOTCGAOT GGAATCAATO OAGCAGATCA ACTAACAAGA GOACCCTOAT OAOCCCCAGO CAGAGOCOIC TCCCTTATOC AOTGTTTGTT AOTAAACACC AGAACGCCAT TOTTOTTACT OCTOAATTTT ATTUOGOGCT AOATGCTTAA OOTAAAAATG ATAAAGGCCT CAAOCCACTO TGTGGGThJ7G OGTCCAAOTC CTOCCTCTCT AACACOCCTO GTTAAAATAA TCCC1TrGGA TOOTOCTOAG AAGCACCTGA TCCCCAAATA ACAATOGCOT GCAAGTOTCT OOTTCCCAOA AGTTGOTOAC TAOGTAAGCA OAOOOOOCTO ATTCCCAGAC AGTCOCCTGT TCCTGCGOO ATOGGOCTGA OOCTTOOOOA OAOOATATOC CATTTOATTC TOTTOCACAC OTTCTTTTrCC CYJTCTTTCTG TATOICTOOT TTCTOTCOTT CCTCACATAG OTTOOACATT GOCCOOCTOC CAGCATAAOT OCCAOTOTGA TGTOAOCTGA GAAAOAGAGG TOOAOOCTAA OCAOOTOTOA TOCTTCTCAO AGOTOCTOAC TCTOAGGAGO GAATCTTTOC TrATCCCTTT GACCAAOGAT CTTTGCTGCA AAOGCTGGOT CTCAOCAAAO COTCAACTCG TOCAAOAACT TAOCAOOAAT AOT-rCTOGCT AAOGTTAOOA AAAGTCTCTT TMGrTTCCT CTOCTTCTCC COITTOCCTC CTTrATCATOA GATCTrrT AOAAAOATTG CATAOTCAGT GCTTCCAGCT CTOCTCCCAC CTGATCCTOC ACTOTCCTCT TOAATOAACT CTGATACCCA ATCTTOTCTC GAGCCTTCTC TATOCCACTC ATOGCTCCTC TCCATCTTrTT TOCTGAGAOT TCTOAOCTCT OTACTTC!CTC YrGGCCCATC TCACTTCCTO GAAGAGOTT OCTTATCTTG ATGGAACTCA AAAAOCCAAA AAGCTGCAGG CAOAGOCOTTF OTTTGOGGAA CTAAGAGCAO CAOCACThrC AOATTCAOTC CATATAOAGC TGTCCTACAG ACTTGAGOAT GTOCOOTOCA TAAAOGGGCT OGAAOTOACC CACGTGTOAT GAGCCCTTTC GGTrCCAAG AOATCACCCC ACCAOAAAAO GOTAGGAATO AGCAAGTTGG OAATTTTAGA ACATOOACCT CTOOOAAGAC OTCTOOCOAO AGCTAGGCCC ACTGGCCCTA CAGACOGATC ACCTGTCCCT OTOOAOGTTC CCCTGOAAG GCAAGATGCC CAACAACAGC ACTGCTCTOT TOTTACCTAC ATCACCATGG AAATTTTCAT TGGACTCTOC OCCATAGTOG GCAACGTGCT OTGOTCAAGC TOAACCCCAG CCTOCAOACC! ACCACCTTCT AfTrCATTOT CTCTCTAGCC TTOCTOTrOG OGTGCTGGTG ATOCCTOTG CCATTOTTOT CAGCCTOOOC ATCACAATCC CTGCCTTMT ATGACTTGCC TACTOCTTAT CTTTACCCAC GCCTCCATCA TOTCCTTOCT OTOOACCGAT ACUOGCOGOT CAAGCTTACC OTCAOOTAOC CTOCOOCOTO GOOTGGOCAO AOCTOGGAAA TOAGOCTACA AAGCCAOAGC CTGCTGAATT TTATITJ70A CTGTACATAT AAGGTAAAAA TOATAAAGCC CTCAAGCCAC TOTOTGOTT GGGTCCAAGT OUTCCTTOCT TAACACGCCT OOTTAAAATA ATCCCTTOO ATOOTOCTGA GAAGCACCTG AACCAAGITGG AACTATGOCG TGCAAGTGTC TGOTTCCCAO AAOTTOOTGA CTAGGTAAGC OACTCAGGOA TTCCCAGACA GTCGCCTGTTF CCTGCTGGGA TGOCTOAG OCTTGGGGA.A TOTOOOCAG 140

CAOTTOOAOA

ACAAOTATOO

AATGATGCCA

CCCACTCTGA

OTACATAT

TTCCUrCTUG

ACCAAOTGOO

OCTTCAOOOA

ATGTGOCAO

CATTCTOCTA

TTITTCTAOO

TTITTTOCCCT

ATCOGCTGTO

OOCTGCACC

CTAAGCTGGC

OOTCCCTGAA

TTCTOC!TCTT

AAACACCCCT

OAGOACATCT

CATTCTGGAA.

TAAGGAGAAG

CTOTCACTOC

TTGCTGGCTC

CATTGGCCAA

GGTCATCTGC

CTOGCTGACA

ACTTCTACAG

OGCCATCGCT

CAATTOAOOC

TTAGATGCTT

GCTGCCTCTC

GTCCCCAAAT

GAGOOOCTOA

AGGATATGCC

ATIGATI'CT GTTGCACACG TTCTTFTCCC TTC1TTCTGT ATGTCTGGTC ATTCTGCTAT CTCACATAGG TTGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TTTGCTAGGG GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG T1TTGCCCT GAATCTTTGC TTATCGCTIrT GJACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG CTAAGCTGGC

TCTGTCGTTC

TGTGAGCTGA

TCTGAGCAGG

CTCAGCAAAG

AAAGTCTCTTF

AGAAAGATTG

TGAATGAACT

TCCATCTfTTT

TGAAGAGGGT

CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATACCCA ATC'FfGTCTC GAGCCYVCTC TGCTGAGAGT TACTGAGCTC TGTACTTCCT TGCTTATCTT GATGGAACTC AAAAAGCCAA ACTAAGAGCA GCAGCACTTr CAGATTCAGT TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC GAGATCACCC CACCAGAAAA GGGTAGGAAT TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TATGCCACTC ATGGCTCCTC TTCTGCTCTT CT[GGCCCAT CTCACTTCCT GAAACACCCC

AAAGCTGCAG

CCATATAGAG

CCACCTGTGA

GAGCAAGTTG

CACTGGCCCT

GCAGAGGCGT

CTGTCCTACA

TGAGCCCTTr

GGAATTTTAG

ACAGACGGA

TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG

TTGGGGAACT

TTGAGGATGT

TTTCCAAGAG

ATGGACCTCT

CTGTCCCTGT

TITACCTACAT

GGTCAAGCTG

GCTGTTGGGG

GCCT-=IAT

GGACCGATAC

GCCCTGGGCC

TGACCTCAGA

CATGGTATAC

ATCTTITACA

GACGGGAGTT

ATCTCTCATC

CTGTCCCATG

ACC1TfGAT

TTCTGAGTAG

AGGGCCTGTA

GTGCTCCCCA

CTCTAATTCA

TTCCCAATAG

AAGAGCAGCA GCACT17CAG A17CAGTCCA GCGGTGCATA AACGGGCTGG AAGTGACCCA ATCACCCCAC CAGAAAAGGG TAGGAATGAG GGGAAGACGT CTGGCGAGAG CTAGGCCCAC GGAGGTTCCC CTGGGAAGGC AAGATGCCCA

TATAGAGCTG

CCTGTGATGA

CAAGTTGGGA

TGGCCCTACA

ACAACAJCAC

CATAGTGGGC

TTCATTGTCT

GCCTGGGCAT

CTCCATCATG

CACCATGGAA

AACCCCAGCC

TGCTGGTCAT

GACTTGCCTA

TTGCGGGTCA

TTTFGCTGGCT

GTACCACAGA

TTCAGCTTCC

TCATTCGGAA

ATTrTTCATTG GACTCTGCGC TGCAGACCAC CACC17CTAT GCCTTTGGCC ATTGTTGTCA CTGCTTATCT TTACCCACGC TGAGGACATC TGTTTGGGGA GCATTCTGGA AACTTGAGGA CTAAGGAGAA GGGTTTCCAA ACTGTCACTG CACATGGACC F CTTGCTGGCT CACCTGTCCC CGAATTCGGG GGACATCTGT TCCTACAGCA TTCTGGAAAC GCCC1TTTCTA AGGAGAAGGG ATTTrAGACT GTCACTGCAC GACGGATCTT GCTGGCTCAC TGCTCTGTCA TTGGCCAATG AACGTGCTGG TCATCTGCGT CTCTAGCCCT GGCTGACATF CACAATCCAC TTCTACAGCT TCCUTGCTGG CCATCGCTGT CTCACAGAAG AATATGGCTG GTTTGGCTGG AACATGAAAC TCCGTCATGA GGATGGACTA TGTGCGCCAT CTATCTTGAC AGAGACAGOT GCATTTATG GCTCTGTCAT GGCTGCCYTTT TGCTGTACAT GGGCATCCTG AAAGAAGTTC AAGGAAACCT AGCTTACCGT CAGATACAAG AGGGTCACCA

GGTGTCATI'C

AATGTCACCT

TCACCTGGAT

CAAACTCAGT

CTGGTGGGAT

TCCTTTCATG

TTTCATCCCC

CTGAACTTAT

TGACCCCCAT

CCAATTTGTT

CTGGTTGTCA

CTAACTCCAA

TTTCTTGT

CCACAGCTTG

CCTATAAAAT

CAAGACGGCT AAGTCCTTGT TTCTGGTTCI

AACTGCATCA

CCAACTCCAT

CCTCAAAGCC

TTATCCATCA

TGCCTGGGCC

ATTATATCTC

GTGTTT-fGGA

AAGAATAAGT

TCTACTTTAA

GATGAACCCT

TGTGTGGTCT

GAGATGACTC

AAGGGATTTT

CCCCACTCCA

GGCCTGACTT

CATGGAGCCT

GGTGACTCAT

TGGTGAGGTA

ATCGTCTATG

GCCATCCCTC

TGTCTCATTG

TACATCCTTG

CTACTCTCTT

TGATTFCTTTG GACACAAGCA ACCTTCAGAT TCCCCATCAA ATTACTTCCA CTGAGGTGGG CCTCCACTTC ATTTTTCCT[

TTGAGAAGAA

CAAACACTTG

AGCATCTCCA

TGTCCT1TCT

GTTTTCCTYFC

GGCTCTAGTT

CCTGCTCTCG

GGGGACAACG TATTATTGAT ATTATTGTCT GAAGGGTGCC TAGTTGACT[ ACTGACAAAA T-rCCATGCCA TFGTGGAATT GAGCAGAGAA GGGCTGAACA TGTGTGTGGT

GAGGATGCCT

GAATI'CCCAG

TGGGTTATTC

TCTCTGACCC

TfTTTTGCAGT TITTTrGGCA

AACAATTACA

CAGGGATGTG

YITTTAATGTC

GACTTGGATC

ACTAACAAGA

AGTAAACACC

GGTAAAAATG

AACACGCCTG

ACAATGGCGT

ATTCCCAGAC

CATYI'GATTC

CCTCACATAG

AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGACTTAAA CTGCTGAATT C ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TTCTCTCTAG TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC ACAAACCCCT TTCCTT7GGTT AGCTGAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT ATTTAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAGG CTTCTTTT[ TTTTTTT GAGTGCTGCC TCCTAGAAAT TTCTCTTGGT AACT-FCCTTC TCTGAAGCAC AGATAAAGAA GTAGAAACAT 11TATGAGGGA CACATTGGAG GCCGATGAAG CTrTTCAAGT TCCAGCAGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATITGGTAA AACTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTFATGC CCCACTCTGA AGTGUrTGTT AGAACGCCAT TGTTGTTACT GCTGAATI= ATTTTGGGCT GTACATATTT AGATGCTTAA

ATAAAGCCCT

GTTAAAATAA

GCAAGTGTCT

AGTCGCCTGT

TGTTFGCACAC

GTTGGACA'rr

CAAGCCACTG

TCCCT-17GGA

GGTTCCCAGA

TCCTGCGGGG

GTFCTITTCC

GGCCGGCTGC

TGTGGGTTfG GGTCCAAGTG TTCCT-rCT7G rGGTGCTGAG AAGCACCTGA ACCAAGTGGG AGTrGGTGAC TAGGTAAGCA GCTrCAGGGA kTGGGGCTGA GGCTTGGGGA ATGTGGGCAG CTTC1TTCTG TATGTCTGGT CATJ7CTGCTA CAGiCATAAGT GCCAGTGTGA TTrrGCTAGG

CTGCCTCTCT

TCCCCAAATA

GAGGGGGCTG

GAGGATATGC

TTCTGTCGTT

TGTGAGCTGA

GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGC~rCTCAG AGGTGCTGAG TITM'GCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CT-rTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTJ7CTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTTG'FrCCT CTGCTTCTCC CGTTTGCCTC C'FfATCATGA GATC1TTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCC11TCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTrr TGCTGAGAGT TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT 141 GCTTATCT-rG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTrGG CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC ATGACTTGCC TACTGCTTAT cT-rTACCCAC GCCTCCATCA ACTTGCGGGT CAAGCYJTACC GTCAGGTAGC CTGCGGCGTG( TGAGGCTACA AAGCCAGAGC CTGCTGAATT TrATTTTGGA TGATAAAGCC CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT GGTTAAAATA ATCCC1TTGG ATGGTGCTGA GAAGCACCTG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GTCGCCTGUT CCTGCTGGGA TGGGGCTGAG GCrrGGGGAA GTTGCACACG TTCT1TTCCC YI7CTTTCTGT ATGTCTGGTC TrrGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT CAGAGGCGTT GAGGACATCT TGTCCTACAG CAT1'CTGGAA GAGCCCFJC TAAGGAGAAG GAATTTTAGA CTGTCACTGC CAGACGGATC TTGCTGGCTC

GTTTGGGGAA

ACTTGAGGAT

GGTTrCCAAG

ACATGGACCT

ACCTGTCCCT

ACTGCTCTGT

GCAACGTGCT

CTCTCTAGCC

ATCACAATCC

TGTCCTTGCT

IGGTGGGCAG

CTGTACATAT

GTTCCTTGCT

AACCAAGTGG

GACTCAGGGA

TGTGGGCAGG

ATTCTGCTAT

TTTGCTAGGG

CATTGGCCAA TGTTACCTAC GGTCATCTGC GTGGTCAAGC CTGGCTGACA YTGCTGTTGG ACTTCTACAG CTGCCTITTT GGCCATCGCT GTGGACCGAT CAATTGAGGC AGCTGGGAAA TTAGATGCTT AAGGTAAAAA GCTGCCTCTC TAACACGCCT GTCCCCAAAT AACTATGGCG GAGGGGCTGA TTCCCAGACA AGGATATGCC ATTTGATTCT TCTGTCGTTC CTCACATAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTGCCCT TCTGAGCAGG TTATCCCTT GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT CTGCTFUCTCC CGTTTGCCTC CTTATCATGA GATCTTMTG CTAAGCTGGC AGAAAGATTG GCTTCCAGCT CCGCTCCCAC ATC'rrGTCTC GAGCCTTCTC TACTGAGCTC TGTACTTCCT GATGGAACTC AAAAAGCCAA GCAGCACT'FT CAGATTCAGT

CTGATCCTGC

TATGCCACTC

CTJTGGCCCAT

ACTGTCCTCT GGTCCCTGAA ATGGCTCCTC TJTCTGCTCTT CTCACTTCCT GAAACACCCC AAAGCTGCAG GCAGAGGCGT CCATATAGAG CTGTCCTACA

ATAAAGGGGC

CACCAGAAAA

CGTCTGGCGA

GCCCTGGGAA

AAGAGCAGCA

GCGGTGCATA

ATCACCCCAC

GGGAAGACGT

GGAGGTTCCC

CACCATGGAA

AACCCCAGCC

TGCTGGTCAT

GACTTGCCTA

T7rGCGGGTCA

TFTTGCTGGCT

OTACCACAGA

'I1TCAGCTTCC

TCATTCGGAA

CAAGACGGCT

AACTGCATCA

CCAACTCCAT

CCTCAAAGCC

YTATCCATCA

TGCCTGGGCC

ATTATATCTC

GTGYI7TTGGA

AAGAATAAGT

TGTGTGTGGT

TGGAAGTGAC

GGGTAGGAAT

GAGCTAGGCC

GGCAAGATGC

GCAC'FfTCAG

AACGGGCTGG

CAGAAAAGGG

CTGGCGAGAG

CTGGGAAGGC

ATITTTCAT'TG

CCACCTGTGA

GAGCAAGTTG

CACTGGCCCT

CCAACAACAG

ATTCAGTCCA

AAGTGACCCA

TAGGAATGAG

CTAGGCCCAC

AAGATGCCCA

TGAGCCCT1

GGAATTTTAG

ACAGACGGAT

CACTGCTCTG

TATAGAGCTG

CCTGTGATGA

CAAGTTGGGA

TGGCCCTACA

ACAACAGCAC

TGAGGACATC

GCATTCTGGA

-TAAGGAGAA

ACTGTCACTG

CTTGCTGGCT

CGAATTCGGG

TCCTACAGCA

TGAATGAACT

TCCATCTTrT

TGAAGAGGGT

TGTTTGGGGA

AACTTGAGGA

GGGTTTCCAA

CACATGGACC

CACCTGTCCC

GGACATCTGT

TTCTGGAAAC

GCCCTTrCTA AGGAGAAGGG A1TTTAGACT GTCACTGCAC GACGGATCYF GCTGGCTCAC TGCTCTGTCA T1TGGCCAATG AACGTGCTGG TCATCTGCGT CTCTAGCCCT GGCTGACATT CACAATCCAC 'ITCTACAGCT GACTCTGCGC CATAGTGGGC

GAATCTTTFGC

CGTCAACTCG

TTTTGTTCCT

CATAATCAGT

CTGATACCCA

TGCTGAGAGT

TGCTTATCTT

ACTAAGAGCA

TGTGCGGTGC

GAGATCACCC

TCTGGGAAGA

TGTGGAGGTT

TTGGGGAACT

TTGAGGATGT

TT[CCAAGAG

ATGGACCTCT

CTGTCCCTGT

TTACCTACAT

GGTCAAGCTG

GCTGTTGGGG

GCCYTTTAT

GGACCGATAC

GCCCTGGGCC

TGACCTCAGA

CATGGTATAC

ATCTfACA

GACGGGAGTT

ATCTCTCATC

CTGTCCCATG

ACCTIT[GAT

TfTCTGAGTAG

AGGGCCTGTA

GTGCTCCCCA

CTCTAATTCA

TrCCCAATAG

GGGCTGAACA

GAGGATGCCT

TGCAGACCAC CACCTTCTAT TTCATTGTCT

GCCTTTGGCC

CTGCTTATCT

AGCTTACCGT

GGTGTCATTC

AATGTCACCT

TCACCTGGAT

CAAACTCAGT

AAGTCCT-fGT

TCTACITTAA

GATGAACCCT

TGTGTGGTCT

GAGATGACTC

AAGGGATTTT

CCCCACTCCA

GGCCTGACTT

CATGGAGCCT

GGTGACTCAT

AYI7GTTGTCA TJ7ACCCACGC

CAGATACAAG

CTGGTGGGAT

TCCTT[CATG

TTTCATCCCC

CTGAACTTAT

TTCTGGTTCT

TGGTGAGGTA

ATCGTCTATG

GCCATCCCTC

TGTCTCATTG

TACATCCTTG

CTACTCTCTT

GCCTGGGCAT

CTCCATCATG

AGGGTCACCA

TGACCCCCAT

CCAATTTG'T

CTGGTTGTCA

CTAACTCCAA

TTTCTTGTr CCACAGC'rrG

CCTATAAAAT

TGATTC1T[-G

ACCTTCAGAT

ATTACTTCCA

TCCTTrGCTGG

CTCACAGAAG

GTTTGGCTGG

TCCGTCATGA

TGTGCGCCAT

AGAGACAGGT

GCTCTGTCAT

TGCTGTACAT

AAAGAAGTTC

GACACAAGCA

TCCCCATCAA

CTGAGGTGGG

CCATCGCTGT

AATATGGCTG

AACATGAAAC

GGATGGACTA

CTATCTTGAC

GCATTYFTATG

GGCTGCCT'rr

GGGCATCCTG

AAGGAAACCT

TTGAGAAGAA

CAAACACTTG

AGCATCTCCA

TGTCCTT-rCT

GTTCCTTC

GGCTCTAGTT

CCTGCTCTCG

CCTCCACTTC ATr1TCCTT GGGGACAACG TATTATTGAT ATTATTGTCT GAAGGGTGCC TAGTTGAC1T ACTGACAAAA TTCCATGCCA TTGTGGAATT GAGCAGAGAA AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTT-rAAGG GGGACTTAAA CTGCTGAATI' C (FRAU.

NO:1675) (SEQ. ID NO:3007) CGAATI'CGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCAC1TI7CAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT OCGGTOCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCT-rTCTA AGGAGAAGGG 1T[CCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGT-rGGGA AT'ITTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TACCTACAT CACCATGGAA ATT1rCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAOCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT T-FCATTGTCT 142

CTCTAGCCCT

CACAATCCAC

TCCTGCTGG

GGCTGACATT GCTGTTGGGG TGCTGGTCAT TTCTACAGCT GCCTTTTTAT GACTrGCCTA CCATCGCTGT GGACCGATAC TTGCGGGTCA GCCTTGGCC ATTGTTFGTCA CTGCTTATCT T-rACCCACGC AGCTTACCGT CAGATACAAG CTCACAGAAG AATATGGCTG GTTTGGCTGG AACATGAAAC TCCGTCATGA GGATGGACTA TGTGCGCCAT CTATCTTGAC AGAGACAGGT GCATITTTATG GCTCTGTCAT GGCTGCCTTT TGCTGTACAT GGGCATCCTG AAAGAAGTTC AAGGAAACCT GACACAAGCA TTGAGAAGAA TCCCCATCAA CAAACACTTG CTGAGGTGGG AGCATCTCCA GCCCTGGGCC TTIGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCTCAGA GTACCACAGA AATGTCACCT TCCTfTCATG CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC ATCTTTTACA TCATI7CGGAA CAAACTCAGT CTGAACTTAT GACGGGAGTT CAAGACGGCT AAGTCCTTGT TTCTGGTTCT

GCCTGGGCAT

CTCCATCATG

AGGGTCACCA

TGACCCCCAT

CCAATGTT

CTGGTTGTCA

CTAACTCCAA

TTFTCTTGTTT

CCACAGCTTG

CCTATAAAAT

TGAT-CTTTG

ACCTTCAGAT

ATTACTI7CCA

CCTCCACTTC

ATCTCTCATC

CTGTCCCATG

ACCTFTTGAT

TTCTGAGTAG

AGGGCCTGTA

GTGCTCCCCA

AACTGCATCA

CCAACTCCAT

CCTCAAAGCC

TITATCCATCA

TGCCTGGGCC

ATTATATCTC

TCTACTTTAA

GATGAACCCT

TGTGTGGTCT

GAGATGACTC

AAGGGATTTT

CCCCACTCCA

TGGTGAGGTA

ATCGTCTATG

GCCATCCCTC

TGTCTCATrfG

TACATCCTTG

CTACTCTCr.

ATTTCCTT TGTCCTTTCT CTCTAATTCA GTGTI'TTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GYTJTCCTTC T[CCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTfGACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTr GGGAACAGAA GAAATAAACT GAGTITAAGG GGGACTTAAA CTGCTGAATT C (FRAU. (SEQ. ID N 0:2439) CTGCTGAATT TTAYTITTGGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT ATGGTGCTGA GAAGCACCTG AAGTTGGTGA CTAGGTAAGC TGGGGCTGAG GCTTGGGGAA 'FrC'TCTGT ATGTCTGGTC AGCATAAGTG CCAGTGTGAT GTTCCTTGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCTrTGG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTTCCCAG GACTCAGGGA GAGGGGCTGA TTrCCCAGACA GTCGCCTGUT CCTGCTGGGA TGTGGGCAGG AGGATATGCC ATTrGATTCT GTTGCACACG TrCTTTTCCC ATJTCTGCTAT TCTGTCGTTC CTCACATAGG MTGCTAGGG TGTGAGCTGA GAAAGAGAGG

TGCTTCTCAG

CFTGCTCCA

AGYITCTGGCT

C11TATCATGA

CTGATCCTGC

TATGCCACTC

CTITGGCCCAT

AGGTGCTGAG

AAGGCTGGGT

AAGGTTAGGA

GATCTTTTfG

ACTGTCCTCT

ATGGCTCCTC

T-ITGCCCT TCTGAGCAGG ATCGGCTGTG CTCAGCAAAG GGCTGCCACC AAAGTCTCTT CTAAGCTGGC AGAAAGATTG GGTCCCTGAA TGAATGAACT TTCTGCTCTT TCCATCTTTT GAATCTI17GC

CGTCAACTCG

TTTGTTCCT

CATAATCAGT

CTGATACCCA

TGCTGAGAGT

TTGGACATTG

TGGAGGCTAA

TTATCCCTYIT

TGCAAGAACT

CTGCTTCTCC

GCTTCCAGCT

ATCTTGTCTC

TACTGAGCTC

GCCGGCTGCC

GCAGGTGTGA

GACCAAGGAT

TAGCAGGAAT

CGTTTGCCTC

CCGCTCCCAC

GAGCCTTCTC

TGTACTrCCT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCAA ACTAAGAGCA GCAGCACTTT CAGATTCAGT AAAGCTGCAG GCAGAGGCGT TGAGGACATC TG'TTTGGGGA CCATATAGAG CTGTCCTACA GCATTCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTTT CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG GGAATTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACOGAT CYI7GCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG (FRAG. NO:j (SEQ. ID NO:2438) GAATrCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCT-rTA T-rCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTfrGCCT ACAGCATGCT GTGTTFTGGAC ACAAACCCCT TTCCTFGGTT TCTCTGACCC AGCTGAGATG GACTGAYITCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGOAGGOT T-TTTGCAGT ATAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAGG C'rrCTfll TTT11TITTT TTTTT[GGCA GAGTGCTGCC TCCTAGAAAT TTCTCTrGGT AACT-rCCTTC TCTGAAGCAC AGATAAAGAA AACAATJTACA GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGYJTGGAGA GGACTGCCCT TITTTAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGOTGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTI'ATGC CCCACTCTGA AGTGTrTG'rr AGTAAACACC AGAACGCCAT TGTTJGTTACT GCTGAATITT AT=TGGGCT GTACATATTT AGATGCTTrAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTrCTTG CTGCCTCTCT AACACGCCTG GTTAAAATAA TCCC1TTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGUTCCCAGA AGTTGGTGAC TAGGTAAGCA GCflCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTITGATTC TGTTGCACAC GTTCTTTTCC c'rrCTrCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TT=GCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TYITGCCCT TCTGAGCAGG GAATCTTTGC T-rATCCCTTT GACCAAGGAT CTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT ThrrGTTCCT CTGCY[CTCC CGTFGCCTC CTITATCATGA GATCT-=fG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTrGTCTC GAGCCT-rCTC TATGCCACTC ATGGCTCCTC 'FrCTGCTCTr TCCATCT=T TGCTGAGAGT TCTGAGCTCT GTACT-rCCTC YJ7GGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCUTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA 143 CTAAGAGCAG CAGCACTTrC GTGCGGTGCA TAAAGGGGCT AGATCACCCC ACCAGAAAAG CTGGGAAGAC GTCTGGCGAG GTGGAGGTTC CCCTGGGAAG ATCACCATGG AAATTTTCAT TGAACCCCAG CCTGCAGACC GGTGCTGGTC ATGCCTTTGG ATGACTTGCC TACTGCTrAT ACTTGCGGGT CAAGC11TACC AGAflCAGTC CATATAGAGC TGTCCTACAG CATFCTGGAA AC~rGAGGAT GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG GGT'FrCCAAG GGTAGGAATG AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC ACCACCTTCT ATTTCATTGT CTCTCTAGCC CTGGCTGACA TTGCTGTTGG CCATTGTTGT CAGCCTGGGC ATCACAATCC ACTTCTACAG CTGCCTTTTr CTTTACCCAC GCCTCCATCA TGTCCTrGCT GGCCATCGCT GTGGACCGAT GTCAGGTAGC CTGCGGCGTG GGGjTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC (FRAG. NO:J (SEQ. ID NO:2437) GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG A'ITCAGTCCA TATAGAGCTG

TCCTACAGCA

GCCCTCTA

ATTTTAGACT

GACGGATCTT

TGCTCTGTCA

AACGTGCTGG

CTCTAGCCCT

CACAATCCAC

TCCYTGCTGG

CTCACAGAAG

GTT-rGGCTGG

TCCGTCATGA

TGTGCGCCAT

AGAGACAGGT

GCTCTGTCAT

TGCTGTACAT

AAAGAAGTTC

GACACAAGCA

TCCCCATCAA

CTGAGGTGGG

ATTTCCT

ATTATTGTCT

ACTGACAAAA

GAGCAGAGAA

TTCTGGAAAC TTGAGGATGT A.GGAGAAGGG TTTCCAAGAG GTCACTGCAC ATGGACCTCT GCTGGCTCAC CTGTCCCTGT( TTGGCCAATG TTACCTACAT TCATCTGCGT GGTCAAGCTG GGCTGACATI' GCTGTTGGGG UTCTACAGCT GCCT=TAT CCATCGCTGT GGACCGATAC AATATGGCTG GCCCTGGGCC AACATGAAAC TGACCTCAGA GGATGGACTA CATGGTATAC GCGGTGCATA AACGGGCTGG ATCACCCCAC CAGAAAAGGG GGGAAGACGT CTGGCGAGAG 3GAGGTTCCC CTGGGAAGGC AAGTGACCCA CCTGTGATGA TAGGAATGAG CAAGTTGGGA CTAGGCCCAC TGGCCCTACA AAGATGCCCA ACAACAGCAC

CACCATGGAA

AACCCCAGCC

TGCTGGTCAT

GACTTGCCTA

TTGCGGGTCA

MFGCTGGCT

GTACCACAGA

TITCAGCTTCC

A1T=1CATTG GACTCTGCGC TOCAGACCAC CACCTI7CTAT GCC'ITTGGCC ATTGTTGTCA CTGCTTATCT TrACCCACGC AGCTTACCGT CAGATACAAG GGTGTCATTC CTGGTGGGAT AATGTCACCT TCCTTTCATG TCACCTGGAT TFFCATCCCC CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT CTGAACTTAT GCATFTATG GACGGGAG17 CAAGACGGCT AAGTCCTTGT T-fCTGGTTCT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTrAA TGGTGAGGTA GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG AAGGAAACCT ACCITTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TTGAGAAGAA 'FrCTGAGTAG TrATCCATCA GAGATGACTC TGTCTCAT7G CAAACAC117G AGGGCCTGTA TGCCTGGGCC AAGGGATTTT TACATCCTTG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTCUT TGTCCTCT CTCTAATTCA GTG=rGGA GGCCTGACTT GGGGACAACG GTT-rTCCTTC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT

CATAGTGGGC

TUCATTGTCT

GCCTGGGCAT

CTCCATCATG

AGGGTCACCA

TGACCCCCAT

CCAATTTGTT

CTGGTTFGTCA

CTAACTCCAA

MTCTTGTTT

CCACAGCYITG

CCTATAAAAT

TGATTCT-TG

ACCTTCAGAT

ATTACTrCCA

CCTCCACTTC

TATTATTGAT

TAGTTGAC1T TTGTGGAATTr GAGT-rTAAGG GGGACT17AAA CTGCTGAATT C (FRAG. (SEQ. ID NO:2427) ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TTCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTfGCCT ACAGCATGCT GTGTTTGGAC ACAAACCCCT TTCCTrGG'rf TCTCTGACCC AGCTGAGATG GACTGA31TCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGOT TFrTTGCAGT ATTTAACTAA GGT-rCAAAGA GTGCTATATA GTGAGAAAGG CTTCTTIrTIT YFTTT1TIT TI'TTTTGGCA GAGTGCTGCC TCCTAGAAAT TTCTCTFrGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATrACA GTAGAAACAT YI7ATGAGGGA CACATTGGAG GCCGATGAAG CTf-TCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT YFITAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTrTGTT AGTAAACACC AGAACGCCAT TGTTGT-rACT GCTGAATI= ATITTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCITCTTG CTGCCTCTCT AACACGCCTG GTTAAAATAA TCCC1TTIGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AG'FrGGTGAC TAGGTAAGCA GCYITCAGGGA GAGGGGGCTG ATITCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC CT-fCT-rTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA 'ITTTGCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTrCTCAG AGGTGCTGAG ITrTGCCCT TCTGAGCAGG GAATCTITGC TFTATCCCTIrT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT 1TFGTTCCT CTGCTTCTCC CGTTGCCTC CTTFATCATGA GATCTITTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA CTGATACCCA ATC'TrGTCTC GAGCCTrCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TGCTGAGAGT TCTGAGCTCT GTAC'FrCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT CTAAGAGCAG CAGCACTTrC AGATTCAGTC CATATAGAGC TGTCCTACAG CATFCTGGAA GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAAYTMAGA CTGTCACTGC 144

TGAATGAACT

TCCATCTT

GAAGAGGGTT

GTTTGGGGAA

ACTTGAGGAT

GG1TTCCAAG

ACATGGACCT

CTGGOAAOAC GTCTGGCGAG GCTAGGCCC ACTGGCCCTA CAGACGGATC UTGCTOGCTC ACCTGTCCCT OTGOAGGTTC CCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CAUTGGCCAA TGTTACCTAC TCACCATGG AAAUUTCAT TGOACTCTGC GCCATAGTGO OCAACGTGCT OOTCATCTGC OTGGTCAAGC TOAACCCCAG CCTGCAOACC ACCACCTTCT AUTTCATTGT CTCTCTAOCC TGGCTGACA TTGCTGT TGO GGTGCTGGTC ATGCCTTTGG CCAUOGTTGT CAGCCTGGOC TCACAATCC ACUTCTACAG CTGcCTTUT ATGACTTOCC TACTGCTTAT CTrTACCCAC CCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACUOGCGGGT CAAGCUTACC GTCAGGTAGC CTGCGGCGTG GGGTGGOCAG CAATrGAGGC AGCTGOGAAA TGAGGCTACA AGCCAOAGC-3' (FRAG. (SEQ. ID NO:2426) '-GOGCAAUTTG UTAGTTATCC GCCGCCACCA AGACGCGGCA COGCOCCTGG ACCGGAOGGG CCCCGCGCGG GCOCGAACTT TGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTOG GTCCCGGCCA CCAGCGCCCC AGCCCCOAGG CTCAGAAGCG OCAGGCGOAG GCGCGGTCCG OGCGCTATGG CCATGCCCGG CGOTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCUTCGG TAOGGOCGC CCGGGGCCCA

GACGCGCTGT

CCGCGGTGGG

CGTGGCCGTG

GGCTGCCTCT

CAGTCGACAG

AGGGGTCAUT

AAAGACAGTO

AGTGTCTCTT

CCCACTGCTT

GAGCTGATGG

TGGGGATTTFJ

GGGTAAAAAT

CCCATTGTCT

TCTGCCAAGC

ATCTAGGCTC

ATTGTGAAAG

GTATCTAGCT

CTGCTTTTAC

ACGTGGCOCT

CACGGCGAAC

GGGCTCTTCG

TCCTCGCCTG

ATACCTGGCC

GCTGTCCTCT

CCACCAACAA

TGAGAATOTG

ATAATGCTGG

ACCACTCOAO

TGCCCTGTGC

AAGCCCAAGT

ATGCTTACCG

AGATGTCAAG

GGAGCTGGTC

ACTCTGCAGA

CCATCCCCUT

CUTCGTGCTG

ATCTGTGTCC

GGGTCCTTGC

CTGCACAGAA

GTCCCCATGA

TGATCTACAT

OACCACCCTC

TGGTTACCTG

OGGCAATGAA

GAACCGAGAC

AGTGGGAATG

ATCGCCGCGC

CGCCCACCAA

TGCCATCACC

GTGCTCACGC

CGCTCAGGTA

CTUTGGCATC

CCCTGGGATG

GCTGGCCCGO

TTTCGGTGGC

CTACUTCCTG

ATCAGCCTGG

AGAGCTCCAT

TAAAAGTTTO

GGOAUGACTC

GAACCACGAA

GCTACATGGT ATAUTTCAAT TAAGATCT TC CTGGTGGCCT CAGCGGGAGA TCCATGCAGC TGCATGCTGT TAACTOTGTC TATGGCCAUT CTTCTGTCAC TTCCOCTACA CTTTTCACAA GTCAGGCTGG GGTACAGCCT CCATOCTGCT GOAGACACAG GGGCAACGTG CTGGTGTGCG GTGTCCCTGG CTGCGGCCGA GCTTCTGCAC TGACUTCTAC CTTCAGCCTT CTGGCCGTGO GTCACGGGGA CCCGAGCAAG CATTCCTGO OTGGAACAGT TOAAAOCTGC TGCCUOGTOA UTCUTGGGT GTG'rrCTGCC GCAGGCAGCT TCAGCGCACT CAAGTCACTG GCCATGATTG ACTCTU-TCC AGCCAGCTCA ATGCCAAU-C AGUTGTCAAT AATTATCTCC AOGTATCTTC GCTCTCGGTG TGGGCCTATG AGAGGACACO GCTOGTTTTC CACT TCCCTG GAGCTACCAC TATATUTATG ATCTAUTCAG CTCTTTTGTT TTUAAAAGTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA ATAGCTACAC CTCACAAGGA AATGGACTOC CTCTCTTGAG AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA TOTGTGGATr ATGCCAACAG CTTGAATGGA TTCTAACAGA TGCCTI7GUT ATOGTGGAAA AUTACTGAAA CTATUTTACT GTOAAACAGT GTGAACTATT ATAATGCAAA TACTTrTAA CTTAGAGGCA ATGGAAAAAT AAAAOUTGAC TGTACTAAAA ATG-3'(FRAG. NO:J(SEQ.ID NO:2425) GB TGC-3' (FRAG. NO:1676) (SEQ. ID NO:1691) 5,-U-G U-G GGC-3' (FRAG. NO:1677) (SEQ. ID NO:1692) CUT CCC BGG G-3' (FRAG. NO:1678) (SEQ. ID NO:1693) GUT GGG CAT CU7 OCC-3'(FRAG. NO:1679) (SEQ ID NO:3) GOC CTA GCT CTC GCC-3' (CRAG. NO:1680) (SEQ ID GAG CA TG TOT TGT TGG OCA TCT TG CUT CCC AGG G-3- (FRAG 982) (SEQ. ID NO: 992) 5'-BCB GB3G GB TGC TOT TGT TOG GCB TCT TGC CUT CCC BGG G-3' (FRAG 983) (SEQ. ID NO: 993) S'-CCC M~ TCT GOT GGG GTG-3' (FRAG 984) (SEQ. ID NO: 994) CTG TTG TTG GGC-3' (FRAG 985) (SEQ. ID NO: 995) CUT CTG TTC CC-3' (FRAG 986) (SEQ. ID NO: 996) TIT TCT OGT GGG GTO-3' (FRAG 987) (SEQ. ID NO: 997) 5'-OTO CTG UTG TTG GGC-3' (FRAG 988) (SEQ. ID NO: 998) CUT CTG TTC CC-3' (FRAG 989) (SEQ. ID NO: 999) Human IgE Receptor D3 Nucleic Acid and Antisense Oligonucleotide Fragments CCC CTO GOT CUT CC CTC CTG CTC U-T UTT C AUT TOG TCT GGT ATT ACT UGC TGT OTC CAT TTlT TTG AUT AAG CGA OCT GT BUT TG TGT GGT BUF BCT UTC TGT GTC GBT lT UGC BTT BBC GB OCT GT-31 (FRAG. NO:1681) (SEQ. ID NO:1694) CTO G0-3' (FRAG. NO:1682) (SEQ. ID NO:1695) 5'-GGTCTGCTBTT-3' (FRAG. NO:1683) (SEQ. ID NO:1696) 5'-CBUBBGCGBGCTG-3' (FRAG. NO:1684) (SEQ. ID NO:1697) CCC GTG GOT CUT CC-3D (FRAG 990) (SEQ. ID NO: 1000) 50-CTC GTG CTC TTlT TUT C-30 (FRAG 991) (SEQ. ID NO: 1001) ATTOCTCTCCTAUTACTrlTCTGTGTCCATITITCAUTAACCGAGCTGT (FRAG 992) (SEQ. ID NO: 1002) BTTlTGCTCTCCTBTTBCUTTCTGTGTCCBTTUUTCBUBBCCGBGCTGT (FR-AG 993) (SEQ. ID NO: 1003) Human Fc-c Receptor CD23 Antigen (IgE Receptor) Nucleic Acid and Antisense Oligonucleotide Fragments 50-GCC TGT GTC TOT CCT CCT OCT TCG UTC CTC TCG U-C CTG CUT GOT OCC CUT OCC G GTG CTG CTC GTC CGG OCT OTO 0 OTG GTG GCC CTG OCT CCG OCT GOT OGG CTC CCC TOO CCT TCO CTG OCT GOC GOC GTG 145 C GGG TCT TGC TCT GGG CCT GGC! TGT GGC CGT GGT TGG GGG TCT TC GCT GCC TCC OTT TGG GTG GC TCT CTG AAT ATT GAC CIT CCT CCA TOO CGG TCC TGC TTG GAT TCT CCC GA TCT CTG BBT BIT rGBC CTT CCT CCB TOG CGG TCC TGC TITG GBT TCT CCC GB-3'(FRAG 1685)(SEQ.ID NO: 1698) CCT CCT-3' (FRAG 1686) (SEQ. ID NO: 1699) 5'-TGT GTC TGT CCT CC-3' (FRAG 1687) (SEQ. ID NO: 1700) GCC CTG GC-3' (FRAG 1688) (SEQ. ID NO: 1701) GGT TGG GG-3' (FRAG 1689) (SEQ. ID NO: 1702) CTO BBT BIT GBC C-3- (FRAGI69O) (SEQ. ID NO:1703) TOT GIC TOT CCI CCd-3D (FRAG 994) (SEQ. ID NO: 1004) 515-GCT TCO T[C CTC TCG TTrC-30 (FRAG 995) (SEQ. ID NO:1005) CTT GOT 0CC CIT7 0CC 0-30 (FRAG 996) (SEQ. ID NO: 1006) CTG CTC CTC COG OCT OTO 0-30 (FRAG 997) (SEQ. ID NO: 1007) 51i-GTC OTO 0CC CTG OCT CCG OCT GOT 000 CTC CCC TOO-3D (FRAG 998) (SEQ. ID NO: 1008) TCO CIG OCT GOC GOC OTO C-30 (FRAG 999) (SEQ. ID NO: 1009) 51R-GGG TCT TOC TCT 000 CCT GOC TOT-3D (FRAG 1000) (SEQ. ID NO: 1010) COT GOT TOO 000 TCT TC-30 (FRAG 1001) (SEQ. ID NO: 1011) 0CC ICC OTT TOG GIG GC (FRAG 1002) (SEQ. ID NO: 1012) CTG AAI AIT GAC CIT CCT CCA TOO COO ICC TOC ITO OAT TCT CCC GA (FRAG 1003) (SEQ. ID NO:1013) CTG BBT BIT OBC CIT CCI CCB TOO COO TCC TOC ITO GBT TCT CCC GB (FRAG 1004) (SEQ.ID NO: 1014) Human IgE Receptor a Subunit Nucleic Acid and Antisense Oli2onucleotide Fragments 0CC ITT CCI GOT ICT CIT OTT OTT ITT 000 OTT TOO CIT ACA OTA GAO TAO 000 AIT CCA TOO CAG GAG CCA ICI ICI ICA TOO ACT CC ITC AAO GAO ACC ITA 001 ITC IGA 000 ACT OCT AAC ACO CCA ICI OGA GC BCB GIB OBO IBO 000 BIT CCB TOO CBO OBO CCB ICI ICI TCB TOO BCT CC ITC BBO OBO BCC TTB GOT TIC TOB 000 BCI OCT BBC BCG CCB ICT GOB GC OTT OTT ITT 000 OTT TOO CIT 0CC ITT CCI 001 ICI CIT BCB GIB OBO IBO 000 BIT CCB TOO CBO OBO CCB ICI ICT ICB TOG BCI CC TTC BBG OBO BCC ITB 001 TTC lOB 000 BCI OCT BBC BCO CCB ICT GOB OC-3' (FRAG. NO: 1691) (SEQ. ID NO:1 704) TOG BCI CC (FRAG. NO: 1692) (SEQ. ID NO: 1705) ICT GGB-3' (FRAG. NO: 1693) (SEQ. ID NO: 1706) 5'-CT OCT BBC BCO-3' (FRAG. NO: 1694) (SEQ. ID NO: 1707) IT 000 OTT 10-3' (FRAG. NO: 1695) (SEQ. ID NO: 1708) lITCCI GTICI CITT TTTITI 000TTTOO CIT-3' (FRAG. NO:1005) (SEQ. ID NO:101S) 5'-ACAOTAOAOIAGOGGAIICCATOOCAOOAGCCACICTCATGGACCC-3'(FRAG.NO:1006)(SEQ.ID NO:1016) AAG GAG ACC ITA GOT TIC IGA 000 ACT OCT AAC ACO, CCA TCT OGA OC-3' (FRAG. NO:1007) (SEQ.

ID NO: 1017) GIB BOIBO 000BITTCCB TGCBO OBOCCB ICI CT ICBTGGBCI CC TTC BBO OBOBCC ITB 001 TIC lOB 000-3' (FRAG. NO:1008) (SEQ. ID NO:1018) OCT BBC BCO CCB ICI GOB C-3- (FRAG. NO:1009) (SEQ. ID NO:1019) 5'-OTTOTTITT000 OTT TOO CI-3' (FRAG. NO:1010) (SEQ. ID NO:1020) 51]-GCC 1117 CCI GOT ICI CIT-3Di (FRAG. NO:1011) (SEQ. ID NO:1021) 5'-BCBGIBGBOIBOOOOBIICCBTGOCBGGBGCCBICTCTTCBOOBCCC-3'(FRAG.NO:012) (SEQ.ID NO:1022) BBO OBO BCC TTrB GOT TTC lOB 000 BCI OCT BBC BCG CCB ICI GOB GC-3' (FRAG.NO:1013) (SEQ.ID NO:1023) Human IgE Receptor (Fe Epsilon R) Nucleic Acid and Antisense Oligonucleotide Fragments TOT GIC TOT CCI CCI OCT ICO ITC CIC ICO TIC CTO CII 001 0CC CIT 0CC 0 GIC CIG CIC CIC COO OCT 0100 OldT CIC 0CC CIG OCT CCO OCT 001000G CIC CCC TOG CCI ICO CIG OCT GOC GOC GIG C CCC BOB BCO BOB CCC GOB CCO BCB GOC COT 001000 IG G CT IC OCT 0CC ICC OTT 100 010 GC OAT CIC IOA AlA TTGA CCI ICC AIG OCO OIC CIG CIT OGA OBI CIC lOB BIB ITOB CCI ICC BTO OCO GIC CIG CIT OGB-3' (FRAG: 1696) (SEQ. ID NO:1709) TIC CIC TCG-3' (FRAG: 1697) (SEQ. ID NO:3001) BC!G BOB C-3' (FRAG: 1698) (SEQ. ID NO: 1711) BIB ITB-3' (FRAG: 1699) (SEQ. ID NO:1712) 101 GIC TOT CCI CCT-30 (FRAG. NO:1014) (SEQ. ID NO:1024) 5D-GCT ICO TTC CIC ICO ITC-31R (FRAG. NO:1015)(SEQ. ID NO:1025) CIT 0010GCC CIT 0CC 0-3D (FRAG. NO:1016)(SEQ. ID NO:1026) CIG CIC CIC COG OCT 010 0-3D (FRAG. NO:1017)(SEQ. ID NO:1027) SD-OIC CIC 0CC CIG, OCT CCO OCT 001 000 CIC CCC TOO-3D (FRAG. NO:1018) (SEQ. ID NO:1028) ICO CIG OCT GOC GOC GIG C-3D1 (FRAG. NO:1019) (SEQ. ID NO:1029) 5D-CCC BOB BCO, BOB CCC GOB CCO BCB-3D (FRAG. NO:1020) (SEQ. ID NO:1030) COT 00110 000 IG CT IC-3D (FRAG. NO:1021) (SEQ. ID NO:1031) 51D-OCT 0CC ICC OTT TOO GIG GC-3D (FRAG. NO:1022) (SEQ. ID NO:1032) 1GB BIBITGB CCIICC BIGGOCOGITC CIGCITGB-3' (FRAG. NO:1023) (SEQ. ID NO:1033) Human High Affinity IgE Receptor Oligonucleotide Fra2ments 146 GCGTTGGTAG CTCTGGTGAA TGCCAAAAGA ATGTGGCAGT TGCTAGCCAT GCTCCTGAAT

ATGTATAAAC

ATTAGTTrATT

TAAAATGTAG

UTAGGATAAC

ATCCCACfT

TGCTAGACCT

GAGTAAGTGG

AAACCAGGCA

GCCTATATT

GATCTTCATG

TGATAGAATG

GTTTTGGTAA

TAATAGAGTT

GCAAAAAAAC

AGATCATGTT

GCCTAGATCC

AGAAAGAGGA

AAATTTGTGG

ATCCCAAAAG

AGTTTGACTT

ACAAGTTACT

TATAGGATTA

TTCAGTAATT

TAGT-rGTACA

ATTCCAGGTG

GCACCATCCT

ATACAGAAAA

GTAAGCACCA

AGTACATCAT

TAATAGTTGG

ATAGTGATAG

ACCTGGCATA

TCTAAGTTGT

ATGCCTATGC

GTAAATATTA

ATGACTAAGA GTTGACTTA GGGGTTAGAT TTTATGTGTT TGAACCCCAA CACCCCAAAA CAAGTTACTT AACCTCACTA AGGTTCAGTT TTCCTGTTTA TATGTACTTT ATAGGATTAT TGTGAAAAAT AAATGAAATA TCAGATTTAT TGTTTGGTAT TCAGAATTAG TTGCTGCTGT TTTATTCTGC TCTCCCTTGC AAACTAAATA GTTGTACACA GATTGACAGA TTAAGAAAGG CTTGTGATTG CTCTGTCTCA CCAGAT-fCCA GGTGTATATG TGGAGGTGGG ATAGGGAGTG AATTGCCCAG TTrGGGCACCA TCCTGAATAT TATCTCTAAA GAAAGAAGCA CAGCTGATGG GTTAACCAGA TATGATACAG AAAACAT17C CTJTCTGCTTr TTGGTTTTAA GAAGCCTTAG ATCTCTCCAG CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG TGGAATGACT GGTTTCATTC AATAGACTI'A ATTCAGCAGT CTGTGGGGAA GAGCAAGGTA GT-rCCTCAAG TGCT-7CAGAT GTGAAGTGGG TTTAAATATA CTGTCCCTGT CTTCTTCAGA AGATAAAATA GGACACTCAT TTAAAAGCAA TCTFGCAAA TGACAAGCCA CTATAGACAT TTCATTTCCA GTATITATCAT TAATATCAGA TCCTGGAAGA AGGTTGAGCC YITGACCTAGA AGAAGAATTA GTAAAGGAAT CCTGGAGAAA GCCCCTGCTG TGTATTTAAA GGAGAAAGGG GGGAAATTAT AATATTAAAA CCATAAGTAA TGGTTTAACT GTCTCTGAAA ATGTTTCCAA ATTTATGCAC TAACTGATCA

GTAAACAAAA

TCTGCCT-rCC GCTAGGAAGT AAAATAAAAT AAATTrATATG TGTGTTCTGA OCCAGATTAG GGCACAGTAG

AATTTGGCAG

AGGGGTTAGA

TAACCTCACT

TTGTGAAAAA

AGTTGCTGCT

CAGATTGACA

TATATGTGGA

GAATATTATC

CATITCC117C

GGAGTCCATG

TrGCTAGCCA TTrTATGTGT AAGA11TCAGT

TAAATGAAAT

GrrTTATTCT

GATTAAGAAA

GGTGGGATAG

TCTAAAGAAA

TGCT=IJGG

UTTCGCTGGT CAGACAGCGG GCAGGAAATT AAACAAGAAA TGCTCCTGAA TATGTATAAA 1TGAACCCCA AATrAGTTAT TTTCCTGTTT ATAAAATGTA ATCAGATTTA T"TTAGGATAA GCTCTCCCTT GCATCCCACT GGCTTGTGAT TGTGCTAGAC GGAGTGGAGT AAGTGGGTAA GAAGCAAAAC CAGGCACAGC TTTTAAGCCT ATATI-rGAAG

ATCATCAGTG

AGCGTTGGTA

CAGTACATCA

TTAATAGTTG

GATAGTGATA

CACCTGGCAT

I1TCTAAGTT

CTATGCCTCT

ATATTAAATT

TGATGGGTTA

CCTTAGATCT

ACTCTACTGT

ATGAATGG

CTATTGGGCA

ACCTAAGGAG

rCCTACCAAG

ACGGTTGGTC

AATCAGATGA

GCTCTGGTGA

TATGACTAAG

GCACCCCAAA

GTATGTACTT

ATGTTITGGTA

GTAAACTAAA

CTCTCACCAG

GCCCAGTTGG

ACCAGATATG

CTCCAGCACA

GTGTAGCCTT

GGAGCAGCTG

TTTCCCAGGG

GAAGCCAGAC

GTAATGAGGG

CTEAAA-ATTC

ACTGTTCTTC GGTAAGTAGA GGGTAGGAAC CTTTACTGTG AAGAAGATGG CTCCTGCCAT GGAATCCCCT GATTCAATTA CCCCTCCCAG GGAGGCCCAA GGTGGTGACT TTTTCTAGGA CATGTGCAAA ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG TGAAAGCTTG GTTCCTTGCA TTTGCTCTGG TAGAGGAGAG AAAGAAGCTC TrTCTTCCCC AGGCAAGTGG GCTGAGCAAC CATCTTCCAG AGTGCAAATT TGATTCTCAT TCCTGAAAAG

CATGGATGTA

ATGTATCCTC

TGGTGTATCA

ATGAGCATGA

TGAFJTCATTG

CATGTCTCAT

CATTTTATAA

ACGTAAGTFTC

ACTTCTTTGG

TTAGTGCCTC

CATAAATATT

CTCA'rfCATT

AAGAGATTGC

ACATAGTGAA

GTTCCCTGGG

TAAGGACAGG

TGACTTTTTT

CCT-rGAACCC

CTFTGAAGTC

ATTrGTGAATG

CTGTGTACCT

GCTCATCTGA

CA'TTTAAG

GATCTTATCC

TCTGGACT-

ACATGTCTGG

ATCTGT11CCT CATTrCTCTCA

TCTCTCTCCT

TTGAGGATGC

CT7GGATCTA

TCTCTGTTCA

TCACTACTTT

CAGAGCTTGG

CACATAATAA

AGTCCTCAIT

TTGGTTTCT-T

GCACCAATAC

TTGACCACTG

TCTCTCTACA

TCCATGGAAT

AGFJTCCACCA

CCACACCCAG

TGCAGCTCCA

GCATrGC'rrr

TGGCCAGACT

AGTCA117CTC

AGACACTTTG

TGAAACTCAG

AGTCCAG'ITC

AATITTGCACT

CTGGAACTGA

AGAAACCTTA

ATATTTAATG

TACAGATACT

TGTITTAAA

TAATTTCTCC

ATTGTCAGAA

TGTCTrrCA

AGAATATA

AATGGTTCCA

ATTCTAGTCC TCTGGAGATA AAGAAGACTG CTGGACACTA GATGGCGTGT TAGCAGGTGA CCTCTCACTA TTTTCTTCGT ACTTTCCCTC TCCACCTTGC TCCTCTGTTT TAGTCAATAA GCATGATCTC GCTCAATAAT TGATTTTFCTG GTGGTTACAT TCTTCTGACT ATATCACCCT ACATCCCC1T GTTCCAGGAA CATATGTTTT TCACTCTGTA TATTTCATCC AGTCCAGTAA TAACAATGGT TGAACATGGC GAAUrGAAAT TAACAGAAGT TCTCCTGCAT ATGTGTCCTG YFCCCCTAGA AATCAAAACA TAT-rGCTTCG TTTGTACTTT

GTCCTCTGTT

CCCATCACTT

C1'TGTCTTTC

CCATGTCTGT

TACATTATTA

GGCTAAGGAA

TTTGTTFATCA

GCCATTCAAG

TATACTTACA

AYTTATCCAT

AGACAGTGTT

AGAGTGAGTC

TC'ITTCTCCC

GGGTCTTrATC

TAAGCCTAGA

CTTGTTCCCT

CTGCTTTCTA

TTJFTT1TCCC

TGCACATATA

TTATTATTGC

CTGGATTTCA

CCATGTATCT

ACTGACTTTC

ATITAAATAGT

CCATAATTCA

TCTACCTCAA

AGCTCAAATC

TGTGTTGGGC

ACCAACAGAA

CAGTTCAA

CCTAAGGTCT

GGAACAATTT

AAGT[-GAAT

GAGAGTGAAC

GTGAGGGATG

TATTrTTATC TTCTrGAAGT CCCTCAGAAA AAGGAGAGAA TGTGACTCTT ACATGTAATG CAATGGCAGC CMTCAGAAG AGACAAATTC GAATACAAAT GTCAGCACCA ACAAGTTrAAT TCCAGGGATA TGGAAATACA GATCTCTCAT CCAAATTTGA AGACAGTGGA GGAAGTCTTC AGTGGTAAGT AGATGGGAAA AAACAGGTTA TTCCAAGGGT TAGGACACCA GAGTGGGAT7 CAAGGCCTCT ACCCCTGCAT TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT CCCAGCACTr TGGGAGGCTG AGGCAGGTGG ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA TCTCTGCTAA AAAATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGTACT CGGGAGGCTG AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTTGCA GTGAGCTGAG ATCACGCCAC TGCCCTCCAG CCTGGGCTAC AGAGCAAGAC TCCGTCTCAA AAAATAAATA AATAAATAAA AAAGACCCCT GCATCTCYT TCTTCTACCC CCTTCCCT[- TGATTACT-rG TATGCCT-7CT TTCAATATTC TAGTCATCTC TCAATATTAT TCCTCCACCC TATrrCCTC TATCTITCT GCCTAGATTC AGGTATATAT TATGTGGTCA AACAGCATGA CATATATGTG AACATI7TCAA AGAGCTGTGT ATCTGGAATA GGATCAAAAG GTTTGACTTA AAGTTrGCT CTGCATAATC CATATGGCAG GACCTGAATA 'TAGGTTGTA CTCTTCGTTA TGAAACATAT CTGGGTACAT 1TCCTTATGT CCTCTGTTGT TACTI7AAGAA CACATATT7C ATGCTTGTrT CATV=ATC ACTCCTACTG CCAACAAATA GCATAGCATG CTTAGGCACA TGTGGCTTAA TTAGCAAATG TTGAATAAAC AAATTAATGA 147 TTTTGAATAG TGACCAATAG GTCTCTTTrFA TACTCTATAT TTTTCTCTTG AGTGAAAAAA AATGTTTFCAA CCTCCATATG TAAATTCCAA ACACAAACTA AAGCAATGTA GAATAGCTTC TTTATTCCCT GGAGTAGGITT CTAGAGAAGT CCTAAAGGAT TGGTCCTAAA TTAATTATGC TTATTATGCT TTCTCCTTTA ATGAATGCTT TTTAATTTTT ACAAAAGCAT TAACCATAGA TGACTCATTA GTGACAAATA TTTGTTGAGT ACCTACCAAC TCCTAAGTAT TGTGTTGGGC A11TCAGAATA GAATGTAGAA CTAGACAGGG TCCCTGACTT GGGAAGAGGA CATTAAATAA AGAATTACAT AAGTAATTAA TTTAAATTAT TTTTTGACAA CTATAATTAA CACTAGAACT GGGAAGTTTC TATAAGGTAA CTCCTAAGCT AAAATTCCCA AGAAAGACTG TTTATTTTCC CCTAACTAAC CTGAAAGGAA YFCTGGCTTrT CAAGTGTTCC ATGTATGGAC TCATCAGGGA CCCAGACTGA CTTTTCAGGA GGGGAAAGGA TTTATCAATA CACAAGACAG CCCTTTAAAA ATCCACT'ITA TGAGCCAAAA AGTGAGT-TAA TGATAATTCA ATGCGTGGCT CTCTflTCTC TATTCATTCT CTCTCTCTTC ATTTATTGTT GTTCTTCAGA CTGGCTGCTC CYITCAGGCCT CTGCTGAGGT GGTGATGGAG

AGCGATATTT

ATGTGATTCT

TGCTACCAAC

CTI'GGAGCAC

ACATGTTTTG

3AGAGGACAA

TAGAACTAGC

GGTCCGAGAG

GCTCTAAGCA

TAGMhCTGA

AAATAAATAA

GGCCAGCCCC

ATGGTGAAGC

TGGAACCTAC

ATAAAAGGTG

CCTTTCAAAA

TGTCT-rTCAC

TCCTAAATAC

AGAGCAGTAT

AAGAAG'FfTT

AATAGACACT

AACAGAAGAT

GCTT-rGTGGC TTATTTrTGTG

CACATGCTCT

TGTAATGAAT

TCTrCCTCAG

TCTCAAGTAC

TACTGTACGG

AGTTFGGTAAA

GTGCCATGGT TGGAGGAACT

TGGTATGAGA

GCAAAGTGTG

GGAAAGGAAA

AAGGGGGGCA

ATCTCAATCT

TTTATGAAGA

AGATTGTGAT

GAAAAAAAGT

GCTGGGAAAG

TATGGAGAGG

AAGAGAGGGA

ATAATAATGT

TGAGACTGAA

TAGATTCCAT

GATITAATTG

TAGCCAATAT

ATAATYI7GAG

TFGGAAGGCA

GAGTAATAGG

GGTCTTGTCA

CTGGAGTTAA

TGT-rAATCTG

CTTTCTCTTA

CATCTGTGTT

TrCTGTTTGC

ACCACAACAT

GCAGCTGGAC

AGCATCCATA

CCTGTGATAC

CTGT-rTCAAA TrAATGTGGT

TACTATTTTG

TTCAAAGTTG

GAAACCAGCA

GGGATGTGTA

CTCCATrACA

TATGAGTCTG

CAAGGTGATC

AATGCCACAG

AGCCCCTCAA

TA17ATAAGG

TTGAAGACAG

CA17ACTGTA GCAGOGGAAG GAAGAGAGAA CT7CTGAGCC TGAGCAGTTG CAGCTTGTAG ACTGGAAAGC CTACCAGACT TGCAATGAGG AGACCTGGGT GATAGTATAT GCCTTGACT-r GTTAAATGGT GATAGTAATA CCTGCTTGCA CTATGAAATT AATATITTGTG AAATGACTTT GTAAACTG'rr AAGCACTACC CAAGCATAAC ATCTCAAAGT CATCTGTTGC TCCTGGGGGA ACACTTATAT TTATCAAATT AATGAAGAAA GGATATAAAG AGCTrGAGGA GCCCATTCCA GCTTAGGAGG AGTCAGTAAG CTGTGTGCCT GTGTATTGAG GGAGGAGGGA ATGGACTTGA GTAGGGAGGT GGACTGCCTC TATGGCCTGT AAGAAAAACT GCTCTCTCCA AACTCTTTAT GCCTGTGAAG TATTCACTT TTAAAAAAGC ATGAGGTCAA GTGCTATGTA CTI17GTCTCTA TAGAATCATT TGATAACTTA GTTJ7GGGGTG CAGCCTGGGT TGAGAATCAC TfTGTCTAGGT ACTAATCACA AAAATCGGTA ATTTAACTAG TGCAAUrTCT CATTGATGAC CCCTGTCCTC TTTCGAATAA GGGGTTTATC GAGGAAATGC TTAGGACTCC TGAAGGAGAA AGTrAGACTT TTCCTfCACA AATACATAAT TAAGTCCTAG CAGTTCTCTG GGCTTCCAGT ATCTTCATCT GJTAAAACAGA AAAAATATAT TGATGCTCAT GTCTCATTTC

ATACGTATTT

GATCTT-rAAA CAGT-ffATAA TCATTT-rGCC

ACTTTGTCCC

TTTCCTAYI7G

CTGTGGCTCC

AGTGTTTTCT CTGTGCYTCT OGATOCCACA

GGGAGGATGA

CCACTACAGC

TGTGGACACA

GAGAACCAGG AAAGGCTFCA TACTCAAGAA ATA'T[GCAA CTTGCAATAT ACATAGAAAC GTTAAGTGGC ATGTAATAGT

AACTCTGAAC

TCCGCGTGAG

GGATTATTTA

GACTTCTGAA

CATTAGTTT

GTCTGTGCTC

AAGTGCTCAA

GATGTTCAAT

GMF7GTT-rGT AT-rGCAAGTG

TCTTCAGCTT

CTCATTYTTC

AAGTACTGGC

TCTCAACTCA

CCCACATCCT

ITTCCAGCAT

AAGGATYI7AT

TTAACATTGG

T-rCAATAAAA TTrGTTTTCTA

CGATCTAGGA

ACTAAATATG

TTCATAGGTC

TGATTTCTGG

ACAGACTAAC

TAACAGGCAT

CT-ffCCACCC

TCTTCCCCTC

AGGGAGCACC

TCACGCTAAA

AGTI'CCCAAG

TACAATTT

GCAGCAGGTC

AAGCCAAACC

CAGCAATTGC

AGAAATGCTT

TTGAATAAAT

TAAATATAAA

CTAAAGGCAA

ATGAAAAGAC

AAC1TTCAGT

TTTCACATAA

ATGTAATAYJ7

AGAACCACAA

GTAAGAAATG

CTJTAATTATA

TGGGCACGGC

AACAGAGCAA

AATGAAGGAC

ATGAATTATG

TATCCCATTG

ACATTTCTCT

CCAAAAACAA

TACTCAATTG

CAT-fAAACTG

GAGAGAATGA

ACCATGTAAC

GGACCATGAA

ATAGGAGGAT

TCTTGGCAGA

CACTTrGTAC

T-FAACTAATT

ATATTITGGTC

TTGAGATTCT

TGGTAATGGG

CTGAGGCTCT

AATAATAGAA

ATGA1TGATT

TGTGAATTCT

ACACTGGCTA

CTCAACCTAG

AAAGCTTGGT

T-ITCTCATTG

TTGGTGGTGA

TGAAGATTAA

CTGATATAAT

TCAAACACAG

AGTGAAACTG

ATAGATTCAT

AGAATGCTTC

GT~rCTAGATT

GCCAGTGAGG

ATCAGGGACA

iTATTAGCAT

TGAGTAYITCA

GGAAATGTCC

TGGATCATTT

GTCTCAAGAC

AATU-ATATC

GCTAATAATA

ACTAGACAGT

'rrGTCATGGA

GCATGGGCCT

CTCCTGCCAT

AGTCCCTCAG

CTTACATGTA

AAGAGACAAA

CCAACAAGTT

GCTGAGGTGG

AGGTGATCTA

TGCCACAGTT

CCCCTCAACA

TGGTGATTCT

TTGTAAAAGA

AGGCTTGCTA

TCTCTTGACT

TTATGCTTCT

ATAGGACTCT

TTGAACTTAT

ATAACCAAAA

TUTGGTTTAT

GTAAATGGGA

ATATTTGAAG

GGAATCCCCT

AAACCTAAGG

ATGGGAACAA

TTCAAGTTTG

AATGAGAGTG

TGATGGAGGG

TTATAAGGAT

GAAGACAGTG

'FrACTGTAAT

GTTTGCTGTG

CAGGATGAAG TAGAGTCCAG GATrCCTCTG TGATEGTTTT GCCCCTCCCA

GTCTTGTATC

CCTTCGGCTC

TITUCCCTTC

TrAAAGTTC CCTTrAGATCT

ACTCTACTGT

TCTCCYJ7GAA MITrCTTGAA

AATATTGTGA

AACCTGTGTA

CCAGCCCCTC

GGTGAAGCTC

GAACCTACTA

AAAAGCTCCG

GACACAGGAT

TTTATACAGC ACCTGAACCA TGAAAACAGT CCAGGACTGA ATTTTATGTC TTCATCATAG TACTAAGAGT CTCCAGCATC

AGCATTTTGG

ATAAGATCT'r

TCATTGGAGG

CTCCACCTGT

CTCCAGCACA GTAAGCACCA GTGTAGCCTT ACTGTrCTrC CCCTCCATGG AATAGAATAT GTCAGTTCCA CCAAATGGTr ATGCCAAAUT TGAAGACAGT CCTGGAAGTC TTCAGTGACT TITCCTCAGGT GCCATGGTTG TCAAGTACTG GTATGAGAAC CTGTACGGGC AAAGTGTGGC CGTGAGAAGT ACTGGCTACA TATTTATCTC AACTCAGCAG TCTGAACCCA CATCCTAAGC AGTTTT'TC CAGCATCAGC GTGCTCAAGG AM~ATAGAA

GGAGTCCATG

GCTCCAGATG

TTAAAGGAGA

CCACAATGGC

GGAGAATACA

GGCTGCTCCT

GAGGAACTGG

CACAACATCT

AGCTGGACTA

ATTrATC

CAGGTCACAT

CAAACCCCAA

AATTGCTACT

ATGCTTCATT

AGAAATTCCA

GGGCAAAAGA

CTCAT-rCTTC

CTACCACCGA

AAGAAGATGG

GCGTGTTAGC

GAATGTGACT

AGCCTITTCAG

AATGTCAGCA

TCAGGCCTCT

GATGTGTACA

CCATTACAAA

TGAGTCTGAG

CCATTGTTGG

TTCTCTTGAA

AAACAACTGA

CAATTGTCAA

AAACTGAGTG

GATTAAGAGA ACCAGGAAAG GCTTCAGACT TATAATrACT CAAGAAATAT T-rGCAACAT7 ACACAGCTTG CAATATACAT AGAAACGTCT 148 AAACTGGTTA AGTGGCATGT AATAGTAAGT GCTCAATTAA CAUFGGTTGA ATAAATGAGA GAATGAATAG ATTCATTTAT TAGCATTTGT AAAAGAGATG TTCAATTTCA ATAAAATAAA TATAAAACCA TGTAACAGAA TGCTTCTGAG TAAAAAAAAA AAAAAAAAAA AAAAAAAA TCTCAATATA ATAATATCT TTATTCCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG AAAGTAATAG GAGAGCAAAT CTTGCTCTCC CACAGGAGCC T-FCCAGTGTG CCTGCATTTG AAGTCTTGGA AATATCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG TCGGCCTCAT CCCCACCACT GCATACATGG CTGACAGTTTF TGAAAAAAGA GCAGGAGTTFC CTGGGGGTAA CACAAATTCT GACTGCTATG ATATGCCTT-r GTTTTGGAAC AGTTGTCTGC TCTGTACTTG ATATTTCACA CATTGAGGGA GACATFITTT CATCATTTAA AGCAGGTTAT CCA71TCTGGG GAGCCATATr TTTTCTATT TCTGGAATGT TGTCAATTAT ATCTGAAAGG AGAAATGCAA CATATCTGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTI7 GCCAGAAATT TITTGAGACC AAGTGCTTTA TGGCTTCC'IT TITCCACTGAA ATTGTAGTGA TGATGCTGTT TCTCACCATT CTGGGACTTG GTAGTGCTGT GTCACTCACA ATCTGTGGAG CTGGGGAAGA ACTCAAAGGA AACAAGGTTC CAGAGGATCG TGTTTATGAA GAATTAAACA TATATTCAGC TACTTACAGT GAGTITGGAAG AACACTCTGA TTCACAGCCA ACCCAGGGGA AATGTCTCCT CCCATTGATT TATAAGAATC ACGTGTCCAG AGGATCCAGA AGGCCAAGGT CTTGTTAAGG GGCTACTGGA AAAATTTCTA TTCTCTCCAC AGCCTGCTGG TTIT AAGCTTTTCA AAGGTGCAAT TGGATAACTT CTGCCATGAG AAATGGCTGA ATTGGGACAC AAGTGGGGAC AATTCCAGAA GAAGGGCACA TCTCTTTCTT TTCTGCAGTFl CTTTCTCACC TTCTCAACTC CTACTAAAAT AAAATTATGC TCCAGGAGTC TCAAATrTTC TTCTATrCAT CACAAGTAAA AGCCTGT7GA TATGTATAAA GAGAATCATC AATGTCATGA AGGAAATCCA CCAAGTCTCA ATATAATAAT CACAGAAAGT AATAGGAGAG CAAATCTTGC TYTTCTACC CTCAGTCACT TGTGGCAGGG ATTTAGGCAT GGATCCATCT AGTTTAATTA GTGGTTCTCT CTCCCTGGAG AGGAACAYT GAAGCTCATT TTCTGGjGTAT GAGACAGGAG ACATGTGCTG AGGGACACAT ATCCTTCACA ATTGGTCTU- ATAATCCATA AGCTGTGGGA GCTATTCAAA GCCATTCCTT CATTGTATTC TCAGATACAT TTCTATGTTA AAAGGATFTGT TCAACATAGA TGAATGAGAA AGAACTTGAA TTGCTCCATT TTGTCCCATC TAATCACTTG TGAGCTTTAG TTTCTTGGTG AYI7ACAATGA CTCCCCTTTrC TGTCTGTCGA GAATGTTGCA AATYFCACAG TGTGCCTGCA TTTGAAGTCT GAAGTCGGCC TCATCCCCAC CACTGCATAC GTGAGTGAGC CTCCTCCAAC YITTGACTAGA GTCTCATTTT CAGGTTCTGT AAATCCTGCT TTATTTCATA 17IAGTCTTTA TTTAGTAGAC TCTTAATCAG CCAAGAAACT TATCTGTCTG GGTAACCCAT TFICAACTGCC TATTCAGAGC ATTCTTTATT CCTGGACAGC TCGGTTAATG TCTCCCACAG GAGCCTCCA GGTAGGTACA GAAGTCATAG TCACGGTGCT TAGGAGATGA ATATATTGGG TATGAGGAAG CTACTTGCTG TTACTCAGCT TGCAAACTGG AAATAGATTT AGTTCATACT GTGTATGTAG ATCTCTGGCT CATGCTTTTA TAAATACTTG ATAAAGTAAC TGCTTCTCTG AAGATGAAAA TAGTAATAGA TGTGCACATG AAGTITGGGGT 31TGTTACTGA GAGATGCATA GGTAAATGTG TTTA'TrTCA AGTAACACTG GATTAAGAAT AGGAAAATTT GATAGTGTTC AGGTGTTCTr GGTCAGTTAC AGATTTGAAT TACAGGATGG CTTTGAAAAA CAGGGAGTTA CAGAATGTTC TCATGACTGA TGGAAATATC TCCCCAGGAA GTATCTTCAG ATGGCTGACA GT1TTGAAAA AAGAGCAGGA GTAAGGGTTG GGTCTAGAAA AGAATATTGA TTAGGTCCTT TAAAAAACAT GGTAGATAAA CATTTCCTCA TAAAGACTTT AAATTGCTAG TCTTTACTTA GATGTAAAGA ACAATTACTG

AGTCTCAGGC

TUCTCAATTT

GCAAATGACT

ATGCAGTAAG

AAAAAATGGA

AGGTATTATT

AACTTTATTG

TACTTTCCAT

TCTCACATTA

TCTGGGTCTG

CTGCYITCTTG

GTCCCATCTA

CAAAATATAT

GTTTTACTTFG

GGCATGGATT

TTGGATGCTC

ATAAACAAAA

ATTGC1TrTA

GCAGACTATT

GTTCCTGGGG

GTTGCATCAA

GAGTTGACAC

GACGAGAATG

ATG'ffCAACA CTGTTTTCCC ACTTGGATTC TAACTGGGTC CTTTTGGGAA

ATGAGAGGTG

GAGCCAGAAG

GCCAACAGGA GTGAAGGATT CATAACTA

TGACTACATA

TCTTATAGTG

ACGCAGTTTC

ATGAAATTCA

GTTGTCTGCT

CATTCTGGGG

TCTCTTTCTC

TATATGTGAG

GGGTTAAACA

TAAGGGCCAC

ACTATTCATC

CTGGGCATGG

AGGAGTTTGA

GTGATAGTGC

AGAGGTITGCA

AATAATAATA

AAACATTAAG

GTATCTCT

TTAAAGGTCT

GACACACATG

CTITGTAACT

GTGAATATAA

CGCTGCACAG

TTAATTCTAG

ACTCTCCTTG

TATTAGGTGT

CATAAAGGCG CATGGAGAAA AGTAUTGGCC 11TCCATGCAT TAGGTAGTGC 'ITGTATCAAT GCTAGGGTAT CCTGGAAAAT CTI7ACGTGTG GATCATYFCT CAGGACAGTC TAGGACACTA TCATGTTTGG CYI7CTATTAT TAAAAAATGA TACAATCTCG GGAAAATTT7 TFTTGATfTTC TGTGTrC TATAGGTAAC ACAAAT-rCTG ACTGCTATGA TATGCCTTTG TTTTGGAACA CTGTACTfGA TATTTCACAC ATTGAGGGAG ACATTTTTTC ATCATT-TAAA GCAGG'ITATC AGCCATATTT GTGAGTATAT ATCTATAATT GTTTCTGAAA TAACACTGAA CATAGGTTTT AGATCTAACC AGTTGTTTAT TCCCAGTATT AAGATGATAT TTATAATTCT TAATTATAAA CATATATAAC ATAGATATOC TCATTAACAA CAACAAAAGA TTCTIJTAC AATTAACGGT TTTAGCCCAC AGTTTTATCC CATGAGAAAC CTGAATCTAA TACAAGTJTAA ATGACTTGCC TTGACTAATA GTAATTGAAC CTAAACTTTC AGAATCCAAC TCCAGGAACA TACTTCTAGC AATAAAGTTA TATGATAAAT ACATACAACT YI'ATCTGTCA ACTAAAAATA ACAACAGAGG TGGCTCACAC CCGTAATCCC AGCACTTTGG GAGGCTGAGG CAGGTGGATC ACCTGAGGTC GACCAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA ATATAAAAAA TTAGCTGAGT ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG CTTGTrTGAA CCTGGAAGGC GTGAGCTGAG ATFTGTGCCAT TGCACTCCAG CCTGGGCAAT AAGTGCGAAC TCTGTCTCAA ATAATAATAG AAAATAAAGT TGTCTTCATG AAAAATGAGG AAAGAGATTG CTGGGGTGAG ATCAATGGGC ATATGGTGAC CTTCTATGCC CTAGAAACTC TTTTANGGTA TTTTCTCCTG TACNCATCGT TCTATCTGGA AAAATAGGTG GATGAGTGAG ATAATAACGG TATATACTTT AATTGACATA TATAAAT7GC AAGTA1TrTCA GATGTCAAYF TGCTAACC'rr GACACACATA AAAACATCAC CACATTAATA CAATGTATGT ATCCATCATT CCAAAAGCTT CCCTGTGTAT CTT-rC'I1CCT CCCTCCACTC CU-GTCCTCT CGTTCCCAAG AAAACATTGA TCTGCTTCCT A117AACTJTAC AFTrAGA GCTTTATATA AGTATGTTCT CTrACTGTT TGTCTTrCCT-r TTATTGAG ATTCTT~CAAG TITMTCTTT ATATCGATAC TrCAT1'CACA AGAATATAUT ACTATGTCAC ATTGACT7TG TCGTCTGCTA AATCCYFrAGT GCTCAGATGA CTTFGTTCAGG AACCTGTACC TCTGTTANAT TGAAACTTGT CTCTACTGTC TThATTrC AAACACAGCT CTCTCAACCC ATCAAACNCA CAATCTGAGT CTFFTAGGAGA TTGCTTTGAA TGTGCTAT 149

TGACTTATAT

TATNTNCACA

GCTGATGGAA

CCTGATGT-rG

GCCTCATGTA

CCCTCATATG

GAGTGCAATG

CCTCCCTAGT

AGGGTTTCAC

CAAAGTGCTG

NTATATNAAA

TGATATATGT

GACNCACATA

CTCGGACAGT

AATGAAGAAT

ATTCATATAC

GCATGATCTT

AGCTGGGACT

CATTJ7TGGTC

GGATTACAGA

TNTGTAAATG TTTGGTAAAA ATATCATCAI CAGACTCTGG AAATATGCAT GCCACAGACA CNAATAGACG ATTGCAGTAG AATGAGAGTC TACTACNCCA AGAGTACCCC CTGCATTGTC TTCATGCTCC ATCCAGGACC TAATGAATAA ACTTTTT-FFT TTTTTTF[TA GATGGAGTCT GGCTCACTGC AACCTCTGCC TCCCGGGTTC ACAGGTGCAT GCCACAGTGG CTGGCTAAYI AGGCTGGTCT TGAACTCATG ACCTCCGGTG CATGAGCCAC CACACCCGCC TJTATTCGTAT TAAGAAAATA TTGGGCTCAC AGGTGACATT GTACNTTTTC ATAAT-rACGC CGTGTTTCTT GCCTAAAGGG GTGGTCTAAN CAGTACATGT AGGGTTAGCA TCTCCTGGAA GAATCTGCAT TTfAGCAAGA CACTCTTGTC GCCCAGGCTG AAGTGATTCT CCTGTCTCAG TTTGTATTrT TAGTAGAGAC ATTCCCCCGC CTCGGCTTCC ACNCATT'TAA TTCTGAGAAG AATAAGTAAC TTTATCGAGT AAACAAGAAC TCATTGTGGC TATATCTGAA AGGAGAAATG ATAAGAAGAA CAGAGTTTTA GATATATOAT 1TGTTTCAA GAAACATAAA TTGTACCAT[ TACACCGGCA TTGTCCTTGT TATTTGAGGA AAGACCGTAC CATrAAACAA TGCGGACATT GGATGCATCC AGCCCTGAAA CACTCTATAG AAAATAAGAA ACCCCAAATT TTACCTATGT TTGGAAGATG GGGTTAAAAG TTTTTTTCC TCCTTTGA ACAGTTTTCT ATTTCTGGAA CAACATATCT GGTGAGTTGC CCGTTTCTGT CTTTGTCCAT AGAGTCTTAA GGGAAACACA TCT117GTCTC CTATATTACT TCTATTTTGT GTCCTAAGGC 1T=TGCAAC AGAAGTTGGA TAACATACAT GAAGTTTATG TTTACCTTGA CGTTCTTCTA AGGCATAT7C ACATGATCAA ATAAAATAAT TAGTTITTAA

GACACATTGA

TGTTGTCAAT

CCTGAAAAG

TGTGAATGTG

TATATCA1TA

AAAAGTGTCC

TTAAGGAGAA

GTGTTCATGT GGTTCCTGAA GGCAGTCCAG TGAGAAAGTA ATATATGCTT TTCAGGGTTT CCCTrrAA CCAAAATTrTG GAAGCAATGT GGAATTTACT TGAAGATAGG TTITATTGAAT GTGCCAGCAA GTGCAGGCCC AGGTCTGAG'I GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TGGCTTCCTT TTCCACTGTA TGTATTTTTTr 1T~GTGTGGG AAGACTAAGA AAGAAGCCCT CTTCTCCTGT TCCATGAACA CCATCCT7TT CTGTAACTTC CTGTAAGTTC ACACAGCCCA GGGAGATGCT GGCTGCCCAC TCCCCTCAAC TAAAGTTATC TACTGCAAGT GACGATCTCT GGGTT1TTCT GTGCCTGTGT GTGTGTGTGT GTATGTGTCA CYITAAAAGG ACTGGTCAGA TGGTAGGGAG AAGAAAATAA ACTTGGGG CGAATACCAA TGTGACTCTT TT[GTTTGTC AAATTGTAGT GATGATGCTG TTI7CTCACCA TTCTGGGACT TGGTAGTGCT AGCTGGGGAA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA GAATTGGAGC TATrCCT-r AAAATATGGC CTGGGTITTC TGAAACATT CAAGTTTTAT TACTTTGGTT TACAAATCTC ACATrAAAT CACATTTTAT CATAATATTC CTCTGAATGA GGGTTGGGAT AATAGGACTG ATATOTTAGA GCATGAGAGA TGGATGTACA GAAGGCTTGT GAGGAAACCA CCCAGGTATC GAACTAGCCG CCTATTCCTG TT-rCTGUYFT ATTCCTITGT 'rCTGACT-r AAACCTCAGT T'rrCTITCCT TTCTGATTCA TGACTACCAA ATGTFFITCAC ACCTYI7GATA AGAACCACCA GACCTTGTGC TCATGTACTr GCCCATGTCT TCCATCTGTC CACTrTCCTG AGGCATTCAA GTCTAGCCAC C'TITTAAAAT ACGGTGTCAC GCCTGTAATC TCAGCACTTT GTGAGGCTGA GGAGGOCGGA AAAACCAGCC TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA CTAAAAAATA CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA AGGTACCTGA GGTITCCAGAT ACTfGGGAGG CTGAAGCAGG AGAATCGCTT GCAGTGAGCC GAGATCATGC CACTGCACCA CAGCCAGGGT GACAGAGCCA GGCCAAAGCT GAAGAATAAT TT1GAGGTGAG GAT-rTGGAGA CCAGCCTGGC TGTACTAAAA ATATAAAACT TAGTGGGGCA TGGGGGCACA CACCTGTAAT AGGCAGGAGA ATTGCTTGAA CCCGGGAGGC GGAAGTTGCA GTGAGCCAAG GCCTGGGTGA CATAGTGAGA YI7CTGTCTCA AAAAAAATAA AAGAAATTTA GATAGATAAA TAAGACAGCA GATATACTAA GGAATAACCT CACCAACTI7G TTTTGGCCCA CTITGGCCAGC TAGTCTGGTT TGGTTTTCTG GAAATGAAAG CAGAGAGCGT GAGACCCAGA AAGACAAAAG TAGATGAGGT AAGTCTCTTG GAAATTTGTG GTGATTGATA TGAAATGATT TTI7CCCTTAT CAGGTTCCAG T7AAACATAT ATrCAGCTAC TTACAGTGAG TTGGAAGACC CAGGGGAAAT AAGAATCACG TGTCCAGAAC ACTCTGATTC ACAGCCAAGG ATCCAGAAGG TACTGGAAAA ATTTCTATrC TCTCCACAGC CTGCTGGTTT TACATTAGAT TTGTT-rCT GCTGCTTCTG TCCACCTTAA TATGCTCC1T CTATTITGTAG TCTTGT-rTTA TATTATGACC ACACACATCT CTGCTGGAAA GTCAACATGT TTGATTATAA CTGTGCAAAT ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG ATAATATTTG GTTCTTAGGG YTFlTITI T=~AGCATT CTTAATAG3T CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTAT-rACT ATGCAAATAT TTTACCACCA GTCAATAATA CATTIIGCC AAGACATGAA ATTGCCTGAA TCACCAGCAC ATTCACTGAC ATGATATTAT TTGCAGAT7G TTTTATTAAG TTACTCGTTG TCTGGGGAGG TAAATAGG'rr AAAAACAGGG AACATrrCAC AAATGTAG TGAAACATTT GTGAAAAAAG AAGACTAAAT AGTGACGTGG AAATGGAAAT AATGG117ATA TCTAAAACAT GTAGAAAAAG AACAAATTAA AGAATAAAGT TAGACAAGCA ACTGGTTGAC TAATACATTA GTTCTTCATFr ATTATCAGGT GAATTACCAT CCTGATCATC

TTTTGAGACC

TTCTGGGTCC

TATTACACAG

CCAGGCAAAT

TTGTGTGTGT

ATGAAAACAG

ATTTGTTGCT

GTGTCACTCA

ATCYJTGAATG

C117CCAGAAA

ACCATAAGTA

AATGCCTTAA

AAGTGCT-rTA

TAATGTAAGT

TATAGTGGTT

TCCTCGGGGT

GTGTGTGTGT

GAGATGCTAT

GTTCAATAGG

CAATCTGTGG

ACAGGTTAAC

ATAGTTUCTC

GCACACATTT

AGTGTGTGGA

TGGCCTTGTT TTCTGCCCCA TTCCTrTCCA ACTTGCTCTA TTGCCTCACC CGTCCATTAC GATGGAAGAA ACATACTCTC CACTCTCCTC CAGGCTGGGC TCACTTGAAG TCAGGAG'rrC AATCTTAAAC CAAATCTCTA CATTAGCCCA GCGTGGTGGC GAGCCCAAGA GATGGAGGTI TACTTCCCAG CACATTGGGA CAACATGGTG AAACTCCGTC YFCAGCTACT TAGGAGGCTG ATCGTGGCCA CTGCACTCCA AAAAATCACT CTCTTCCAAA TCATJ7GACTG ACATGATTrC AAATAATCAG AGT1TrAATGA AGCGAGACUT CTAGGGATGG AGGATCGTGT TTATGAAGAA GTCTCCTCCC ATTGATTTAT CCAAGGTTTT GTTAAGGGGC TTATTCGCCT GATAAGAATA ATATGATAGA CTCCTATMT AGTAAGCAAG ATTTAACTGT AGTTAAACTT TGACAGTTTG ACAG17GGGC ATGATITGTA TACACTATAT ATAACTTCCT GTTTTATAAA GATCTGTATA ACAAGTAGGA AGTGGGGAAC AAATTATAAG TGCAGAGATT TAAGACCTGA GCTGAAATAA AGTAACTGGT AGAYITTGT7 AGCGTTTGAG TCTAAGATGA AAGGAGAACA CTGG'ITATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG AGGCTCACGC CTGTAATCCC 150

AGCCCYTGG

AAACCCCGTC

CTACTTGGGA

ACCAGTGCAC

AAAAGTCAGA

GATITTGGGG

AGATAAAATT

CTAAGAGAAT

CTAAGGATAA

AGGTAGCCCA

TTGGGCAAGA

CAATAGTGAA

GAGGCCGAGG TGGGCAGATC ACGAAGTCAG TAGTTTGAGA CCAGCCTGGC CAACATAGTG TCTACTAAAA ATACAAAAAA AAAATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG GGATGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC TCCAGCCTTG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAGATA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCATT TITGGCTrT AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC CAATACATGA GTfCTGGTAA TGATACACGG TUGGTGTCA TTATAAGAGA AATCATTATT AAATGAAGCA AGTTAACACT TATTTUGAGA TAGAAGTGAA GCTAAGCTAA ACTTCACATG CCTATAATTG GAGGGAAAAA AATCTAGCCT AGAAGATACA ATAATTAGTC ATAAACATGC ATTGTGAAAC TGTAGAGAGC AAATAGAGAA AGATTAGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC GAAAAGTCCA CAGTGATAAG CAACTCCACC TGAATGCAAA AGGTGCTGAG CAAATTCCAC AAACAYITGC AAAGACCTTIT AGAGAAAGAG AATGGGAGCA TAGAAGGTAG TGAAGAAAAG CAAGCTAAGA AAAAATTCTG TAAGGCATGA ATATGCGGCA GAGAAAACAG ACATGAGTAT TGTGCATGAG TAAATGAATA TATGTGCGAA ATAAGATAGT TGA11TATGAA TTTATAAAAG AAGGAAAAGA TAGTTTATGT AAATCAGTCT GAGAGTATTA GTCACAATTA AAAAGGTGAC AGGTAGATGT TAAYICCCT TAAGTGACTr GGTATGCTTT ATTTAATTGT TITTGTTTCT CCAAATTTGA CAGCAGAATA FTTAGCCTA AGTATAAGAG

ATGAAATAAT

AGATTGTGAA

AGGGCCTGAG

AAAACCCTAC

CACATCACTT

GGATCCAATC

ATCATTGACT

TGCCCCACCC

TTCACACTAT

CTGAATGAAC

GTATCATTAA

TGGAATAATG

ATGGGGAATT

AGCTCTTITAT

GCACACTCTA

AATTGATGGA

TACTTGCTAT

AATITGGAAC

YI7TGGTAATC

TTTCAAAGGA

CAGCACYJ7TA

TACATTTTAT

AGTGATCACG

GTTTITCCATT

CC'T1CACTG

CCATGGCATG

TATATCTTTA

ACATATTTCT

TACCTGCCTT

CACTGCCCCA

ACCTTTTCAT

TTATTAGTGT

TAACTTGATT

AAGGCATCAA

CAAACAGAAC

TAAACAACCC

ATAGAGTTGA

GTAAACTTGA

TCCTACAGAT GGACTGAAAA GTATTGAGGA TGCCAAGATT ACAATCACAC AACAAATAAT CTCATTT1TC

TGTATCATGC

GATGTTCACA

CAGTTGTATA

TATACACAAC

TTATAGTACG

AATTGTCTT[

CCAGCCTTAA

GCTTFGTGACC

TCTTATCTGT

TAAAATACAA

TAAGCTGCAT

TACAGACTCT

GTATATGATA

ACACAATTTA

CCCACCTCAG

CTAAATTTCA

TTTCTTGCTC

TCCTTATGTA

GTTTGTGT-fG

CTCTACTCTT

TAACCCTGGT

TCTCTTTTAT

TGAATTTTTT

GCAGACACAG

ACTTCAATGT

CATAACTACT

TTCTCAATTA

GCATGCAAGA

GATCATCTGT

TTACCAGGAC

TTCACTCAAT

CTCAAGATCA

AGCACAATGC

CATCTITCTCC

CTATCCCACG

CCTGTAT7TG

TTTAGGTACT

AGGTATTAAT

CTCTAGGAGT

TTATATTTTC

11TCTGAGAGT

TGGGGTTCTC

ATGAAGACCA

ATGCAGTATT

TGCAATAAAT

TATCAAGATA

TAAAATGATG CCAAAGACCA AGAGCAGTTT CTGAAGTCCT CCTITCATC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA ACAATCACCA ATAGCCAGAA AACAGAATGT AAGGACAATC AAGGAACTGG AGCATGAGTC ATATTTGACC GAAAGCTTTT TTCTCTTTGT GAACCTCAGG AAAAGATTCC TAACTGGTCT TTCTGUTCCC ATATTCTGTG ACAATTACTT AGTTTGTGGT TGAGATAGCA ACACGAATCA GTAGCTCTCC ACTFTGGGTA AAGAAGTGAT GCNGGTCGTG GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA ACCAGCCATC 1TTTTGTCAAT AGTCAGTCCT CACTCTTATT T'TrACATCT GAAAATGAGA AT-TTTCAAT ATTTAGGATT GAACTATTTG GTGGACATAT GTGGCTCACG CCTGTAATCC GACCATCCTG GCTAACACGG CGGGCGCCTG TAGTCCCACG TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA GGCGTGGTGG TACTCGGGAG GCTGAGGCAG GAGAATGGCA TGAACCAGGG AGGCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG CAAAAGAGCA AGACTGCGTC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG TAGGAGGACA CCTGCAACAA TAATAT=~ CTAAATCCCT CTGAAAAATG CTAATCAAAG GGT'TrTTrC CTAAAAATTG TCTTAGAAAT AAAATTTCCC CTT-rGGGAGA CCGAGGCTGG CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTGAAACCC CGTCTCTACT AAAAATACTA AAAATTAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC CAGCTACTTG GAGGCTGAGG CTGGAGAATC ACGTGAAC-3' (FRAG. NO:j(SEQ.

ID NO:2505) 5'-AACAAGAAAA GCGTTGGTAG CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT GCTCCTGAAT

ATGTATAAAC

ATTAGTTATT

TAAAATGTAG

YJTAGGATAAC

ATCCCACT11T

TGCTAGACCT

GAGTAAGTGG

AAACCAGGCA

AGTACATCAT ATGACTAAGA GTTTGACTTA GGGGTTAGAT TTTATGTGTT TGAACCCCAA TAATAGTTGG CACCCCAAAA CAAGTTACTT AACCTCACTA AGGTTFCAGTT TTCCTGTTTA ATAGTGATAG TATGTACTTT ATAGGATTAT TGTGAAAAAT AAATGAAATA TCAGATTrAT ACCTGGCATA TGTTTGGTAT TCAGAATTAG TTGCTGCTGT TTFTATTCTGC TCTCCCTTGC TCTAAGTTGT AAACTAAATA G117GTACACA GATTGACAGA TTAAGAAAGG CTTGTGATTG ATGCCTATGC CTCTGTCTCA CCAGATTCCA GGTGTATATG TGGAGGTGGG ATAGGGAGTG GTAAATATTA AATTGCCCAG YI7GGGCACCA TCCTGAATAT TATCTCTAAA GAAAGAAGCA CAGCTGATGG GTTAACCAGA TATGATACAG AAAACATTTC CUrCTGCTT-r TrGG'TrTAA GCCTATAYFI7 GAAGCCTTAG ATCTCTCCAG CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG-3' (FRAG.

NO:j(SEQ. ID NO:2500) TGGAATGACT GGTTTCATTC AATAGACTTA ATTCAGCAGT CTGTGGGGAA GAGCAAGGTA TGATAGAATG GTrCCTCAAG TGCTTCAGAT GTGAAGTGGG TTTAAATATA CTGTCCCTGT CTTCTTCAGA GTTTTGGTAA AGATAAAATA GGACACTCAT TTAAAAGCAA TCT-rrGCAAA TGACAAGCCA CTATAGACAT TAATAGAGTT TTCATTTCCA GTATTATCAT TAATATCAGA TCCTGGAAGA AGGTTGAGCC TTJGACCTAGA GCAAAAAAAC AGAAGAAYI7A GTAAAGGAAT CCTGGAGAAA GCCCCTGCTG TGTATTTAAA GGAGAAAGGG AGATCATGTT GGGAAATTAT AATATTAAAA GTAAACAAAA GCTAGGAAGT AAAATAAAAT AAATTATATG GCCTAGATCC CCATAAGTAA TGGT'rrAACT TCTGCCT7CC TGTGTTCTGA OCCAGATrAG GGCACAGTAG AGAAAGAGGA GTCTCTGAAA ATGTITCCAA 1TTCGCTGGT CAGACAGCGG ATCATCAGTG AATCAGATGA AAATTTGTGG ATTTATGCAC TAACTGATCA GCAGGAAATT AAACAAGAAA AGCGTTGGTA GCTCTGGTGA ATCCCAAAAG AATITGGCAG TUGCTAGCCA TGCTCCTGAA TATGTATAAA CAGTACATCA TATGACTAAG AGT'I1TGACTT AGGGGTTAGA TTrTATGTGT UTGAACCCCA AATTAGTTAT TTAATAGTTG GCACCCCAAA ACAAGYI7ACT TAACCTCACT AAGATTCAGT T-TCCTGTr ATAAAATGTA GATAGTGATA GTATGTACTT

TATAGGATTA

TTCAGTAATT

TAGTTrGTACA

ATTCCAGGTG

GCACCATCCT

ATACAGAAAA

GTAAGCACCA

TTGTGAAAAA TAAATGAAAT ATCAGAMrA TTTrAGGATAA AGTTGCTGCT GTTTTATTCT GCTCTCCCTT GCATCCCACT CAGATTGACA GATTAAGAAA GGCTTGTGAT TGTGCTAGAC TATATOTOGA GGTGGGATAG GGAGTGGAGT AAGTGGGTAA GAATATTATC TCTAAAGAAA GAAGCAAAAC CAGGCACAGC CAT11TCCTTC TGCTTTT-rGG TTAAGCCT ATATTTGAAG GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT

CACCTGGCAT

TTTCTAAGTT

CTATGCCTCT

ATATTAAAYTT

TGATGGGTTA

CCTTAGATCT

ACTCTACTGT

ATGTITGGTA

GTAAACTAAA

CTCTCACCAG

GCCCAGTTGG

ACCAGATATG

CTCCAGCACA

GTGTAGCCTT

ACTGTTCTTC GGTAAGTAGA GATTCAATTA CCCCTCCCAG GGAGGCCCAA ATGAATTTGG GGAGCAGCTG GGGTAGGAAC CTTTACTGTG GGTGGTGACT 117TTCTAGGA CATGTGCAAA CTATTGGGCA TTTCCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG AGGCAAGTGG GCTGAGCAAC ACCTAAGGAG GAAGCCAGAC

TGAAAGCTTG

TAGAGGAGAG

CATGGATGTA

GTTCCTTGCA TTTGCTCTGG CATCUTCCAG AGTGCAAATT TCCTACCAAG GTAATGAGGG AAAGAAGCTC TTTCTrCCCC TGATTCTCAT TCCTGAAAAG ACGGTTGGTC CTTAAAATTC GATCTTATCC CCACACCCAG ATTCTAGTCC TCTGGAGATA AAGAAGACTG CTGGACACTA ATGTATCCTC TCTGGACTTIT TGCAGCTCCA GATGGCGTGT TAGCAGGTGA TGGTGTATCA ACATGTCTGG GCAfrGCTTT CCTCTCACTA TTTfCTTCGT ATGAGCATGA ATCTGTTCCT TGGCCAGACT ACTTTCCCTC TCCACCTTGC TGATTCATTG CATJTCTCTCA AGTCATTCTC TCCTCTGTTT TAGTCAATAA CATGTCTCAT TCTCTCTCCT AGACACTTTG GCATGATCTC GCTCAATAAT CATTATAA TTGAGGATGC TGAAACTCAG TGATTTTCTG GTGGTTACAT ACGTAAGTTC CTJ7GGATCTA AGTCCAGTTC TCTTCTGACT ATATCACCCT ACTTCTTTGG TCTCTGTTFCA AAT11TGCACT ACATCCCCY GTTCCAGGAA TTAGTGCCTC TCACTACTTT CTGGAACTGA CATATGTTTT TCACTCTGTA CATAAATATT CAGAGCTTGG AGAAACCTTA TATTTCATCC AGTCCAGTAA CTCATTCATT CACATAATAA ATATTTAATG TAACAATGGT TGAACATGGC AAGAGATTGC AGTCCTCATT TACAGATACT GAATrGAAAT TAACAGAAGT ACATAGTGAA TTGGTTTCUT TGTT[TAAA TCTCCTGCAT ATGTGTCCTG GTTCCCTGGG GCACCAATAC TAATTTCTCC TTCCCCTAGA AATCAAAACA TAAGGACAGG TrfGACCACTG ATTGTCAGAA TA'FfGCTTCG TTTGTACTTT

GTCCTCTGTT

CCCATCACTT

CTTGTCTTTC

CCATGTCTGT

TACATTATTA

GGCTAAGGAA

T-TGTTrATCA

GCCATTCAAG

TATACTTACA

ATTTATCCAT

AGACAGTGTT

AGAGTGAGTC

TCTUTCTCCC

GGGTCYITATC

TAAGCCTAGA

C117GTTCCCT

CTGCTTTCTA

TY17TYITCCC

TGCACATATA

TTATfATTGC

CTGGATTTCA

CCATGTATCT

ACTGACTTTC

ATTAAATAGT

CCATAATTCA

TCTACCTCAA

AGCTCAAATC

TGTGTTGGGC

'CCAACAGAA

CAGTTTTCAA

TGACTTTT

CCYITGAACCC

C'TTTGAAGTC

ATTGTGAATG

CTGTGTACCT

GCTCATCTGA

CATTIAAG

AGGCAGGTGG

AAAATATATA

AGGCAGGAGA

CCTGGGCTAC

TCTTCTACCC

TCCTCCACCC

CATATATGTG

CTGCATAATC

TTCCTTATGT

CCAACAAATA

TTTTGAATAG

CCTCCATATG

CTAGAGAAGT

TTCTCCTTFTA

TGACTCATrA

TGTGTTGGGC

TCTCTCTACA

TCCATGGAAT

AGTTCCACCA

CCAAA1TTGA

GGAAGTCTTC

TGTCTTTTCA

AGAATATTTA

AATGGTTCCA

AGACAGTGGA

AGTGGTAAGT

TATFTTTATC

AAGGAGAGAA

CAATGGCAGC

GAATACAAAT

TCCAGGGATA

TITCVITGAAGT CCCTCAGAAA CCTAAGGTCT TGTGACTCTT ACATGTAATG GGAACAATTT CTT-rCAGAAG AGACAAATTC AAGTTI7GAAT GTCAGCACCA ACAAGTTAAT GAGAGTGAAC TGGAAATACA GATCTCTCAT GTGAGGGATG TAGGACACCA GAGTGGGATT CAAGGCCTCT CGCCTGTAAT CCCAGCACT[ TGGGAGGCTG AGATGGGAAA AAACAGGTTA TCCAAGGGT ACCCCTGCAT TGGCTGGGCA CAGTGGCTCA

ATCACGAGGT

TATATAAAAT

ATGGTGTGAA

AGAGCAAGAC

CCTrCCCTrr

TATTTTCCTC

AACATTTCAA

CATATGGCAG

CCTCTGTTGT

GCATAGCATG

TGACCAATAG

TAAATTCCAA

CCTAAAGGAT

ATGAATGCTT

GTGACAAATA

CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA TCTCTGCTAA TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGTACT CGGGAGGCTG CCCAGGAGGT GGAGGTTGCA GTGAGCTGAG ATCACGCCAC TGCCCTCCAG TCCGTCTCAA AAAATAAATA AATAAATAAA AAAGACCCCT GCATCTCfTr TGATTACTTG TATGCCTTFCT TTCAATATTC TAGTCATCTC TCAATATTAT TATCTITTCT GCCTAGATTC AGGTATATAT TATGTGGTCA AACAGCATGA

AGAGCTGTGT

GACCTGAATA

TACTTAAGAA

CTTAGGCACA

GTCTCTTTTA

ACACAAACTA

TGGTCCTAAA

'ITTAATTTTT

TTTGTTGAGT

ATCTGGAATA

TTAGGTTGTA

CACATATTTC

TGTGGCTTAA

TACTCTATAT

AAGCAATGTA

TTAATTATGC

ACAAAAGCAT

ACCTACCAAC

CTAGACAGGG

GGATCAAAAG

CTCTTCGTTA

ATGCTTGMT

TTAGCAAATG

TTTTCTCTTG

GAATAGCTTC

TTATTATGCT

TAACCATAGA

TCCTAAGTAT

TCCCTGAC1T

GTTTGACTTA

TGAAACATAT

CATTYI'TATC

TTGAATAAAC

AGTGAAAAAA

TTJTATTCCCT

AGCGATATTT

ATGTGATTCT

TGCTACCAAC

CTrGGAGCAC

AAGTT-TGCT

CTGGGTACAT

ACTCCTACTG

AAATTAATGA

AATGTTY[CAA

GGAGTAGGTT

CC'rrTCAAAA

TGTCTIFTCAC

TCCTAAATAC

AGAGCAGTAT ATfTCAGAATA GAATGTAGAA GGGAAGAGGA CATTAAATAA AGAATTACAT AAGTAATTrAA 1T'AAATTAT ACATGT1TTrG AAGAAGT1T 1TI'GACAA CTATAATTAA CACTAGAACT GGGAAGTTTC TATAAGGTAA GAGAGGACAA AATAGACACT

CTCCTAAGCT

CTGAAAGGAA

CCCAGACTGA

CCCTTTAAAA

ATGCGTGGCT

GTTCTTCAGA

GTGCCATGGT

TGGTATGAGA

GCAAAGTGTG

AAAATTCCCA

TfCTGGCTTT CTTTTrCAGGA ATCCACTTrA

CTCTTTTCTC

CTGGCTGCTC

TGGAGGAACT

ACCACAACAT

GCAGCTGGAC

AGAAAGACTG TTTATTTCC CAAGTGFFCC ATGTATGGAC GGGGAAAGGA T'ITATCAATA TGAGCCAAAA AGTGAGTTAA TATTCATTCT CTCTCTCTJ7C CTTCAGGCCT CTGCTGAGGT GGGATGTGTA CAAGGTGATC CTCCATTACA AATGCCACAG TATGAGTCTG AGCCCCTCAA CCTAACTAAC TAGAACTAGC AACAGAAGAT TCATCAGGGA GGTCCGAGAG GCTTFGTGGC CACAAGACAG GCTCTAAGCA TTATTGTG TGATAATI'CA TAG'FTrCTGA CACATGCTCT ATTTATTGTT AAATAAATAA TGTAATGAAT GGTGATGGAG GGCCAGCCCC TCTI7CCTCAG TAT7ATAAGG ATGGTGAAGC TCTCAAGTAC TTGAAGACAG TGGAACCTAC TACTGTACGG CAI1'ACTGTA ATAAAAGGTG AG'TGGTAAA GGAAAGGAAA AGCATCCATA GCAGGGGAAG GAAGAGAGAA CT-rCTGAGCC TGAGCAGTTG CAGCTTGTAG AAGGGGGGCA CCTGTGATAC ACTGGAAAGC CTACCAGACT TGCAATGAGG AGACCTGGGT GATAGTATAT ATCTCAATCT CTG1TCAAA GCCT-rGACT-r GTTAAATGGT GATAGTAATA CCTGCTTGCA CTATGAAATT TIfTATGAAGA TTAATGTGGT AATATTTGTG AAATGACTT7 GTAAACTGTT AAGCACTACC CAAGCATAAC 152

AGATTGTGAT

GAAAAAAAGT

GCTGGGAAAG

TATGGAGAGG

AAGAGAGGGA

ATAATAATGT

TGAGACTGAA

TAGATTCCAT

GATTTAATTG

TAGCCAATAT

ATAATT[GAG

TTGGAAGGCA

GAGTAATAGG

GGTCTTGTCA

CTGGAGTTAA

TGTTAATCTG

C'FrTCTCTTA

CATCTGTGTT

TTCTGTTTGC

GAGAACCAGG

TACTCAAGAA

CUTGCAATAT

GTTAAGTGGC

TTATTAGCAT

TGAGTATrCA

GGAAATGTCC

TGGATCATTT

GTCTCAAGAC

AATTITATATC

GCTAATAATA

ACTAGACAGT

TACTATTT-rG ATCTCAAAGT CATCTGTTGC TCCTGGGGGA ACACTTATAT TTCAAAGTTG AATGAAGAAA GGATATAAAG AGCTTGAGGA GCCCAYFCCA GAAACCAGCA AGTCAGTAAG CTGTGTGCCT GTGTATTGAG GGAGGAGGGA GTAGGGAGGT GGACTGCCTC TATGGCCTGT AAGAAAAACT GCTCTCTCCA GCCTGTGAAG TATTFCACTTr TGAAGGAGAA AGT-rAGACTT TTCCTTCACA TTAAAAAAGC ATGAGGTCAA AATACATAAT TAAGTCCTAG CAGTTCTCTG GTGCTATGTA CYJ7GTCTCTA GGCTTCCAGT ATCTTCATCT GTAAAACAGA TAGAATCATT TGATAACTTA AAAAATATAT TGATGCTCAT GTCTCAT1TC GTTITGGGGTG CAGCCTGGGT ATACGTATTT TTCATAGGTC TTTCACATAA TGAGAATCAC TrGTCTAGGT GATCT1TAAA TGA1TTCTGG ATGTAATAT[ ACTAATCACA AAAATCGGTA CAGTITTATAA ACAGACTAAC AGAACCACAA ATTTAACTAG TGCAAT-FTCT TCATTrfGCC TAACAGGCAT GTAAGAAATG CATTGATGAC CCCTGTCCTC ACTTTGTCCC CTTCCACCC CTTAATTATA TTTCGAATAA GGGGTTTATC TTTCCTATTG TCTTCCCCTC TGGGCACGGC GAGGAAATGC UTAGGACTCC CTGTGGCTCC AGGGAGCACC AACAGAGCAA

TTATCAAATT

GCTTAGGAGG

ATGGACTTGA

AACTCTTTAT

CACT'1fGTAC

TTAACTAATT

ATATTUGGTC

TTGAGATTCT

TGGTAATGGG

CTGAGGCTCT

AATAATAGAA

ATGATTGATT

TGTGAATTCT

ACACTGGCTA

CTCAACCTAG

AAAGCTTGGT

TTTCTCATTG

TTGGTGGTGA

TGA-AGATTA-A

CTGATATAAT

TCAAACACAG

AGTGAAACTG

ATAGATTCAT

AGAATGCTTC

GTTCTAGATT

GCCAGTGAGG

ATCAGGGACA

AGTGTTI1TCT CTGTGCTTCT GGATGCCACA

GGGAGGATGA

CCACTACAGC

TGTGGACACA

AAAGGCTTCA

ATAT-TGCAA

ACATAGAAAC

ATGTAATAGT

TTGTAAAAGA

AGGCTTGCTA

TCTCYITGACT

TTATGCTTCT

ATAGGACTCT

Th7GAACTTAT

ATAACCAAAA

T[TGGTTTAT

AACTCTGAAC

TCCGCGTGAG

GGATTATTTA

GACTTCTGAA

CATTAGT'TTT

GTCTGTGCTC

AAGTGCTCAA

GATGTTCAAT

GTIfTGTTTGT

ATTGCAAGTG

TCTTCAGCTT

CTCATTITC

AAGTACTGGC

TCTCAACTCA

CCCACATCCT

TTTCCAGCAT

AAGGATTTAT

TTAACATTGG

17CAATAAAA

TTGTT=CTA

CGATCTAGGA

ACTAAATATG

TCACGCTAAA AATGAAGGAC AGTTCCCAAG ATGAATTATG TACAATTJT TATCCCATTG GCAGCAGGTC ACATTTCTCT AAGCCAAACC CCAAAAACAA CAGCAATTGC TACTCAATTG AGAAATGCTT CATJTAAACTG TTGAATAAAT GAGAGAATGA TAAATATAAA ACCATGTAAC CTAAAGGCAA GGACCATGAA ATGAAAAGAC ATAGGAGGAT AACTfrTCAGT TCTTGGCAGA CAGGATGAAG TAGAGTGCAG GATTCCTCTG TGATTGTTTT GCCCCTCCCA GTCTTGTATC TTTATACAGC ACCTGAACCA AGCATTTTGG AGAAATTCCA CCTTCGGCTC TGAAAACAGT CCAGGACTGA ATAAGATCTr GGGCAAAAGA TTTCCCTTTC ATTTATGTC TTCATCATAG TCATTGGAGG CTCATTCTTC TTrGTCATGGA GTAAATGGGA TTAAAGTTC-3' (FRAG. NO:J)(SEQ. ID NO:2501) CTCCAGCATC CTCCACCTGT CTACCACCGA GCATGGGCCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GTGTAGCCTTr ACTGTTCTTC GCTCCAGATG GCGTGTTAGC AGTCCCTCAG CCCTCCATGG AATAGAATAT TTAAAGGAGA GAATGTGACT CTTACATGTA GTCAGTTCCA CCAAATGGTT CCACAATGGC AGCCTTTCAG AAGAGACAAA ATGCCAAATT TGAAGACAGT GGAGAATACA AATGTCAGCA CCAACAAG'Tr ATATTTGAAG CCTTAGATCT CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGCCTCT GCTGAGGTGG TTCCTCAGGT GCCATGGTTG GAGGAACTGG GATGTGTACA AGGTGATCTA TCAAGTACTG GTATGAGAAC CACAACATCT CCATTACAAA TGCCACAGTT CTGTACGGGC AAAGTGTGGC AGCTGGACTA TGAGTCTGAG CCCCTCAACA CGTGAGAAGT ACTGGCTACA* AT'FrTTTATC CCATTGTTGG TGGTGATTCT TATTTATCTC AACTCAGCAG CAGGTCACAT TTCTCTTGAA GATTAAGAGA TCTGAACCCA CATCCTAAGC CAAACCCCAA AAACAACTGA TATAATTACT AGTYTTTT-C CAGCATCAGC AAYITGCTACT CAATTGTCAA ACACAGCTTG GTGCTCAAGG AYITATAGAA ATGCYTCATT AAACTGAGTG AAACTGGTTA GCTCAATTAA CATTGGITGA ATAAATGAGA GAATGAATAG ATTCATTTAT

GGAATCCCCT

AAACCTAAGG

ATGGGAACAA

TTCAAGTTTG

AATGAGAGTG

TGATGGAGGG

TTATAAGGAT

GAAGACAGTG

TTACTGTAAT

GTTITGCTGTG

NCCAGGAAAG

CAAGAAATAT

CAATATACAT

AGTGGCATGT

TAGCATTTrGT

ACTCTACTGT

TCTCCTTGAA

TTTCTTTGAA

AATATTGTGA

AACCTGTGTA

CCAGCCCCTC

GGTGAAGCTC

GAACCTACTA

AAAAGCTCCG

GACACAGGAT

GCTTCAGACT

TTGCAACATTr

AGAAACGTGT

AATAGTAAGT

AAAAGAGATG

TTCAATT'rCA ATAAAATAAA TATAAAACCA TGTAACAGAA TGCTTCTGAG TAAAAAAAAA AAAAAAAAAA AAAAAAAA-3' (FRAG. (SEQ. ID NO:2502) ATAATATrCT TTATTrCCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG AAAGTAATAG GAGAGCAAAT CTTGCTCTCC CACAGGAGCC TTCCAGTGTG CCTGCATrTG AAGTCTTGGA AATATCTCCC

CAGGAAGTAT

TGAAAAAAGA

AGTTGTCTGC

CCATTCTGGG

CATATCTGGT

CCTGATCATC

AAGTGCTTTA

GTAGTGCTGT

TGTTTATGAA

CCCATTGATT

CT-rCAGGCAG GCAGGAGTTrC

TCTGTACTTG

GAGCCATATT

GAGAGGAAGC

AACCTGAAGA

TGGCTTCCTT

ACTATTGAAG TCGGCCTCAT CCCCACCACT GCATACATGG CTGGGGGTAA CACAAATTCT GACTGCTATG ATATGCCT1Tr ATATTTCACA CATTGAGGGA GACATTT1T CATCATTI7AA 1T[TCTATT TCTGGAATGT TGTCAATTAT ATCTGAAAGG CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT '1TCCACTGAA ATTGTAGTGA TGATGCTGTT TCTCACCATT

CTGACAGTTT

GTT-rTGGAAC

AGCAGGTTAT

AGAAATGCAA

GAArTACCAT T1TTTGAGACC

CTGGGACTTG

GTCACTCACA ATCTGTGGAG GAATTAAACA TATATTCAGC TATAAGAATC ACGTGTCCAG

CTGGGGAAGA

TACTTACAGT

AACACTCTGA

ACTCAAAGGA AACAAGGTTC CAGAGGATCG GAGTrGGAAG ACCCAGGGGA AATGTCTCCT TTCACAGCCA AGGATCCAGA AGGCCAAGGT CTI7GTTAAGG GGCTACTGGA AAAATTTCTA TFICTCTCCAC AGCCTGCTGG 1TTTT-3'(FRAG.NO:J(SEQ.ID NO:2S03) 5'-AAGYCT1TTCA AAGGTGCAAT TGGATAACTT CTGCCATGAG AAATGGCTGA ATTrGGGACAC AAGTGGGGAC AATTCCAGAA GAAGGGCACA TcTCTTT T-rcTGCAGTT CTrTCTCACC TTCTCAACTC CTACTAAAAT GTCTCATTTT CAGGTTCTGT AAATCCTGCT AGTCTCAGGC AAAATTATGC TCCAGGAGTC TCAAATITC 153 TYrATTTCATA TrAGTCTTTA TTTAGTAGAC TTCTCAATTT TTrCTATTCAT TCTTAATCAG CCAAGAAACT TATCTGTCTG GCAAATGACT TATGTATAAA GGTAACCCAT TTCAACTGCC TATTCAGAGC ATGCAGTAAG AGGAAATCCA ATTCTT-FATT CCTGGACAGC TCGGTTAATG AAAAAATGGA CACAGAAAGT TCTCCCACAG GAGCCTTCCA GGTAGGTACA AGGTATTATT T IrIITICTACC GAAGTCATAG TCACGGTGCT TAGGAGATGA AACTTTATTG ATTTAGGCAT ATATATJ7GGG TATGAGGAAG CTACTTGCTG TACTTTCCAT GTGGTTCTCT TTACTCAGCT TGCAAACTGG AAATAGATTT TCTCACATTA GAAGCTCATT AGTTCATACT GTGTATGTAG ATCTCTGGCT TCTGGGTCTG ACATGTGCTG CATGCTUrTTA TAAATACTTG ATAAAGTAAC CTGCTTCTTG ATTGGTCTTT TGCTTCTCTG AAGATGAAAA TAGTAATAGA GTCCCATCTA GCTATTCAAA TGTGCACATG AAGT-FGGGGT TTGTTACTGA CAAAATATAT TCAGATACAT

GAGAATCATC

CCAAGTCTCA

AATAGGAGAG

CTCAGTCACT

GGATCCATCT

CTCCCTGGAG

TTCTGGGTAT

AGGGACACAT

ATAATCCATA

GCCATTCCTT

TTCTATGTTA

TGAATGAGAA

TITGTCCCATC

TTTCTTGGTG

TGTCTGTCGA

TGTGCCTGCA

TCATCCCCAC

CTCCTCCAAC

ACTTGGA17C C1TTTTGGGAA

GTGAAGGATT

AATGTCATGA

ATATAATAAT

CAAATCTTGC

TGTGGCAGGG

AGTTTAATTA

AGGAACATTT

GAGACAGGAG

ATCCTJTCACA

AGCTGTGGGA

CATTGTATTC

AAAGGATTGT

AGAACTTGAA

TAATCACTTG

ATTACAATGA

GAATGTTGCA

TTTGAAGTCT

CACTGCATAC

TrTGACTAGA

ATGAGAGGTG

GAGCCAGAAG

CATAACTTTA

CACAAGTAAA AGCCTG'TGA

GAGATGCATA

AGTAACACTG

GATAGTGTTC

AGATTTGAAT

CAGGGAGTTA

TGGAAATATC

ATGGCTGACA

GTAAGGGTTG

GGTAAATGTG

GATTAAGAAT

AGGTGTTCUr

TACAGGATGG

CAGAATGTTC

TCCCCAGGAA

GT=~GAAAA

GGTCTAGAAA

TTTAT'FrTCA AGGAAAAYI7T GGTCAG11TAC

CTTTGAAAAA

TCATGACTGA

GTATCTTCAG

AAGAGCAGGA

AGAATATTGA

GTTTTACTTG TCAACATAGA GGCATGGATT TTGCTCCATT TTGGATGCTC TGAGCmTAG ATAAACAAAA CTCCCCTFC ATTGC'FrTTA AATCACAG GCAGACTATT GAAGTCGGCC GTTCCTGGGG GTGAGTGAGC GTTGCATCAA CTGTTTTCCC TTAGGTCCTT TAAAAAACAT GGTAGATAAA CAT-ITCCTCA TAAAGACTTT AAATTGCTAG TCTTTACT-rA GATGTAAAGA

AGTATTGGCC

CTTACGTGTG

TAAAAAATGA

ACAAA1TCTG

A'ITGAGGGAG

ATCTATAATT

TCCCAGTATT

TCATTAACAA

CATGAGAAAC

CTAAACTT-rC

ACATACAACT

AGCACTTTGG

TGAAACCTCA

TAAGAGGCTG

TGCACTCCAG

TGTCTTCATG

CTTCTATGCC

AAAATAGGTG

AAGTATYI7CA

CAATGTATGT

CTrGTCCTCT

GCTTTATATA

TTTTfCT-r

TCGTCTGCTA

TGAAACTTGT

CAATCTGAGT

TTTGGTAAAA

AAATATGCAT

ATTGCAGTAG

AGAGTACCCC

ATCCAGGACC

T-FCCATGCAT

GATCATTTCT

TACAATCTCG

ACTGCTATGA

ACATTTC

G3TTTCTGAAA

AAGATGATAT

CAACAAAAGA

CTGAATCTAA

AGAATCCAAC

ACAATTACTG

TAGGTAGTGC

CAGGACAGTC

GGAAAATrT

TATGCCTTTG

ATCATrTAAA

TAACACTGAA

TTATAATTCT

TTC1TTTTAC TACAAGTrTAA

TCCAGGAACA

GAGTTGACAC

iACGAGAATG

ATGTTCAACA

TTGTATCAAT

TAGGACACTA

TTTGATTFTTC

TTTTGGAACA

GCAGGTTATC

CATAGGTTTT

TAATI'ATAAA

AATTAACGGT

ATGACTTGCC

TACTTCTAGC

ACAACAGAGG

ACCTGAGGTC

TTAGCTGAGT

CCTGGAAGGC

TCTGTCTCAA

CTGGGGTGAG

TT=CTCCTG

TGACTACATA CATAAAGGCG CATGGAGAAA

TAACTGGGTC

GCCAACAGGA

TCTTATAGTG

ACGCAGTfTC

ATGAAATTCA

GTTGTCTGCT

CATTCTGGGG

TCTCTTTCTC

TATATGTGAG

GGGTTAAACA

TAAGGGCCAC

ACTATTCATC

CTGGGCATGG

AGGAGTTTGA

GTGATAGTGC

AGAGGTTGCA

AATAATAATA

AAACATTAAG

GTATCTCTTT

TfAAAGGTCT TTATCTGTCA ACTAAAAATA GAGGCTGAGG CAGGTGGATC TCTCTACTAA ATATAAAAAA AGGCAGGAGG CTTG~rTGAA CCTGGGCAAT AAGTGCGAAC AAAAATGAGG AAAGAGATTG

GCTAGGGTAT

TCATGTTTGG

TGTGTrMTC

CTGTACTTGA

AGCCATATTT

AGATCTAACC

CATATATAAC

TFTAGCCCAC

TTGACTAATA

AATAAAGTTA

TGGCTCACAC

GACCAGCCTG

ATACCTGTAA

GTGAGCTGAG

ATAATAATAG

ATCAATGGGC

TACNCATCGT

AAYITGACATA

AAAACATCAC

CT-TTCTITCCT

ATTAACTTAC

TTATTUTGAG

ACTATGTCAC

AACCTGTACC

CTCTCAACCC

NTATATNAAA

TGATATATGT

GACNCACATA

CTCGGACAGT

AATGAAGAAT

CTAGAAACTC

GATGAGTGAG

GATGTCAATT

ATCCATCATT

CGT-7CCCAAG

AGTATGTTCT

ATATCGATAC

AATCCT1TAGT

CTCTACTGTC

CYJTTAGGAGA

ATATCATCAT

GCCACAGACA

AATGAGAGTG

CTGCAT-rGTC

TM~ANGGTA

CCTGGAAAAT

CTTFCTATTAT

TATAGGTAAC

TATT-FCACAC

GTGAGTATAT

AGTTGT-TTAT

ATAGATATGC

AGT1TTTATCC GTAATrGAAC

TATGATAAAT

CCGTAATCCC

ACCAACATGG

TCCAGCTACT

ATITGTGCCAT

AAAATAAAGT

ATATGGTGAC

TCTATCTGGA

TATAAATTGC

CACATTAATA

CCCTCCACTC

ATTTTTAGA

ATTCTTCAAG

ATTGACTUTG

TCTGTTFANAT

ATCAAACNCA

TNTGTAAATG

CAGACTCTGG

CNAATAGACG

TACTACNCCA

YI7CATGCTCC

ACTTTT=

GGCTCACTGC

ACAGGTGCAT

AGGCTGGTCT

ATAATAACGG TATATACiT' TGCTAACCT[ GACACACATA GACACACATG

CCAAAAGCTT

AAAACATTGA

CTTTACTGT[

TTCATTCACA

GCTCAGATGA

TTF=ATTTC

TTIGCTTTGAA

GTACNTrTC

CCCTOTGTAT

TCTGCTTCCT

TGTCTTCCTI'

AGAATATATT

CTTG'ITCAGG

AAACACAGCT

TTTGTGCTAT

ATAATTACGC

CTTTGTAACT

GTGAATATAA

CGCTGCACAG

TTAATTCTAG

ACTCTCCITG

TATTAGGTGT

TGACTTATAT

TATNTNCACA

GCTGATGGAA

CCTGATGTTG

GCCTCATGTA

CGTGTrTCTT GCCTAAAGGG GTGGTCTAAN CAGTACATGT AGGGTTAGCA TCTCCTGGAA TAATGAATAA GAATCTGCAT TTTAGCAAGA nTTT1TTTA GATGGAGTCT CACTCTTGTC GCCCAGGCTG AACCTCTGCC TCCCGGGTTC AAGTGATTCT CCTGTCTCAG GCCACAGTGG CTGGCTAATT TTTGTATTFM TAGTAGAGAC CCCTCATATG ATTCATATAC GAGTGCAATG GCATGATCTT CCTCCCTAGT AGCTGGGACT AGGG1TICAC CAT[TGGTC TGAACTCATG ACCTCCGGTG ATTCCCCCGC CTCGGCTTCC CAAAGTGCTG OGATTACAGA CATGAGCCAC CACACCCGCC TITATTCGTAT ACNCATTTAA TrCTGAGAAG CACTCTATAG AAAATAAGAA TAAGAAAATA TrrGGGCTCAC AGGTGACATT AATAAGTAAC TTTATCGAGT ACCCCAAATT 1TACCTATGT TFrGGAAGATG GGGTTAAAAG GACACATTGA AAACAAGAAC TCATTGTGGC 1TlTCC TCCTm'GA ACAGTTfCT AmTCTGGAA TGTTGTCAAT TATATCTGAA AGGAGAAATG CAACATATCT GGTGAGTTGC CCGT'ITCTGT CTTTGTCCAT CCTrGAAAAG ATAAGAAGAA CAGAGTTTTA AGAGTC'ITAA GGGAAACACA TCTTTGTCTC CTATATTACT TGTGAATGTG GATATATGAT TTTG'TrTCAA TCTAT1TfGT GTCCTAAGGC ITI'TTGCAAC AGAAGTTGGA TATATCATTA GAAACATAAA TTGTACCATT TAACATACAT GAAGT1TATG TITTACCTTGA CGTTCTTCTA AAAAGTGTCC TACACCGGCA TrGTCCTTGT AGGCATATTC ACATGATCAA ATAAAATAAT TAGTTTTCAA 117AAGGAGAA TATTTGAGGA AAGACCGTAC GTGTTCATGT GGTTCCTGAA GGCAGTCCAG 154

TGAGAAAGTA

GAAGCAATGT

GTGCAGGCCC

CAGCATAGCT

ATCCACAGTTF

TTTGTGTGGG

CCATCCTTT

GGCTGCCCAG

GGGTTTTTCT

ACTGGTCAGA

TGTGACTCTT

TTCTGGGACT

AGATAGAAGC

CTGGGTTTTC

ACATTTAAAT

AATAGGACTG

GAGGAAACCA

ATTCCTTTGT

TGACTACCAA

TCATGTACTT

GTCTAGCCAC

GTGAGGCTGA

ATATATGCTT CATTAAACAA TGCGGACATT TTCAGGGTTT CCCTTTTrAA CCAAAATTTG GGAATTTACT GGATGCATCC AGCCCTGAAA TGAAGATAGG TTTAFrGAAT GTGCCAGCAA AGGTCTGAGT GTTCTTCATT ATTATCAGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC GCCAGAAA11T TTrTGAGACC AAGTGCTTTA TGGCTTCC17 TTCCACTGTA TGTATT AAGACTAAGA TI7CTGGGTCC TAATGTAAGT AAGAAGCCCT CTTCTCCTGT TCCATGAACA CTGTAACT7C TATTACACAG TATAGTGcYTr CTGTAAGTTC ACACAGCCCA GGGAGATGCT TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT TAAAGTTATC TACTGCAAGT GACGATCTCT GTGCCTGTGT TTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTATGTGTCA CTFTAAAAGG TGGTAGGGAG ATGAAAACAG GAGATGCTAT AAGAAAATAA ACTTTTGGGG CGAATACCAA TTTGTTTGTC ATTTGTTGCT GTTCAATAGG AAATTGTAGT GATGATGCTG flTCTCACCA TGGTAGTGCT GTGTCACTCA CAATCTGTGG AGCTGGGGAA GAACTCAAAG GAAACAAGGT

CCGATATAAA

TGAAACATTT

CACATrTTAT

ATATGTTAGA

ATCTTGAATG

CTTCCAGAAA

ACCATAAGTA

AATGCCTTAA

CCCAGGTATC TGGCCTTGTTr TTCTTGACTT TTCCTTTCCA ATGTTFlTCAC TTGCCTCACC GCCCATGTCT GATGGAAGAA CTTTTAAAAT CACTCTCCTC GGAGGGCGGA TCACTTGAAG

ACAGGTTAAC

ATAGTTTCTC

GCACACAT[

AGTGTGTGGA

T-rCTGCCCCA

ACTTGCTCTA

CGTCCATTAC

ACATACTCTC

CAGGCTGGGC

TCAGGAGTTC

GAATTGGAGC TrATTCCTf AAAATATGGC CAAGT1TAT TACTTTGGTT TACAAATCTC CATAATATTC CTCTGAATGA GGGTTGGGAT GCATGAGAGA TGGATGTACA GAAGGCTTGT GAACTAGCCG CCTAT-FCCTG T-FTCTGTTTT AAACCTCAGT TTrCTT-rCCT T-rCTGATTCA ACCTTTGATA AGAACCACCA GACCTTGTGC TCCATCTGTC CACTTI7CCTG AGGCATfCAA ACGGTGTCAC GCCTGTAATC TCAGCACTTT AAAACCAGCC TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA AATCTJTAAAC CAAATCTCTA CTAAAAAATA CAACAAAACA AAACAACAAC

AACAAAAACA

CTGAAGCAGG

CAGCCAGGGT

GATTTGGAGA

TGGGGGCACA

GGAAGTTGCA

AAAAAAATAA

GGAATAACCT

GAAAAGGAAA CATITAGCCCA AGAATCGCTT GAGCCCAAGA GACAGAGCCA TACTTCCCAG CCAGCCTGGC CAACATGGTG CACCTGTAAT TTCAGCTACT GTGAGCCAAG ATCGTGGCCA AAGAAATTTA AAAAATCACT CACCAACTTG TCATTGACTG GCGTGGTGGC AGGTACCTGA GATGGAGGYF GCAGTGAGCC CACATTGGGA GGCCAAAGCT AAACTCCGTC TGTACTAAAA TAGGAGGCTG AGGCAGGAGA CTGCACTCCA GCCTGGGTGA CTCTTrCCAAA GATAGATAAA ACATGATTTC T-rTTGGCCCA GGTTCCAGAT ACTTGGGAGG GAGATCATGC CACTGCACCA GAAGAATAAT TTGAGGTGAG ATATAAAACT TAGTGOGGCA ATTGCTTGAA CCCGGGAGGC CATAGTGAGA TTCTGTCTCA TAAGACAGCA GATATACTAA CTTGGCCAGC TAGTCTGGTT TGGTITTCTG GAAATGAAAG AAATAATCAG TAGATGAGGT AAGTCTCTTG AGCGAGACTT YJTTCCCT-FAT CAGGTTCCAG AGGATCGTGT TTGGAAGACC CAGGGGAAAT GTCTCCTCCC ACAGCCAAGG ATCCAGAAGG CCAAGGrTT CTGCTGGT7T TACATTAGAT TTATTCGCCT TATGCTCCTT CTATTTGTAG ATATGATAGA CTGCTGGAAA GTCAACATGT AGTAAGCAAG AGAAGGCTGG CTGAAAGTTG AGTTAAACTT ~GTTTAATGA CAGAGAGCGT GAGACCCAGA AAGACAAAAG

CTAGGGATGG

I17ATGAAGAA ATlGATTTAT

GTTAAGGGGC

GATAAGAATA

CTCCTATTTT

ATTTAACTGT

GAAA1TIGTG

'ITAAACATAT

AAGAATCACG

TACTGGAAAA

TTTTGTTTCT

TCTTGTTrTA

TTGATTATAA

GTGATrGATA

ATTICAGCTAC

TGTCCAGAAC

A'ITTCTATTC

GCTGCTYUCTG

TATTATGACC

CTGTGCAAAT

TGAAATGATT

TTACAGTGAG

ACTCTGATTC

TCTCCACAGC

TCCACCTTAA

ACACACATCT

ACAGAAAAAA

TGACAGTTTG ATAATATTTG GYJTCTTAGGG TTTTTT TTTTAGCAT-r CTTAATAGTT ACAGTTGGGC ATGATTTGTA CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTATTACT TACACTATAT ATAACTTCCT ATGCAAATAT TTFTACCACCA GTCAATAATA CATTTT-rGCC AAGACATGAA GTrATAAA GATCTGTATA A17GCCTGAA TCACCAGCAC ATTCACTGAC ATGATAYJTAT TTGCAGATTG ACAAGTAGGA AGTGGGGAAC TTTTATTAAG TTACTCGTTG TCTGGOGAGG TAAATAGGTT AAAAACAGGG AAATTATAAG TGCAGAGATT AACATTTCAC AAATGTAG TGAAACATrT GTGAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AGTGACGTGG AAATGGAAAT AATGGTTATA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGATTTTGTT AACAAATTAA AGAATAAAGT TAGACAAGCA ACTGGTTGAC TAATACA'FrA AGCGYITGAG TCTAAGATGA AAGGAGAACA CTGGTTATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG AGGCTCACGC CTGTAATCCC AGCCC17FGG GAGGCCGAGG TGGGCAGATC ACGAAGTCAG TAGTTTGAGA CCAGCCTGGC CAACATAGTG AAACCCCGTC TCTACTAAAA ATACAAAAAA AAAAYI7AGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG CTACTTGGGA GGATGAGGCA GGAGAATCGC T-rGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCAGTGCAC TCCAGCCTUG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAGATA AAAAGTCAGA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAAYI7 AAGTCTCAT[f TTTTGGC1T[ GAT=rGGGG AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC CAATACATGA GT-rCTGGTAA AGATAAAATT TGATACACGG TfTGGTGTCA TTATAAGAGA AATCAUTAU AAATGAAGCA AGTTAACACT CTAAGAGAAT TATITUGAGA TAGAAGTGAA GCTAAGCTAA ACTTCACATG CCTATAATTrG GAGGGAAAAA CTAAGGATAA AATCTAGCCT AGAAGATACA ATAATI'AGTC ATAAACATGC ATI'GTGAAAC TGTAGAGAGC AGGTAGCCCA AAATAGAGAA AGATTAGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC TTGGGCAAGA GAAAAGTCCA CAGTGATAAG CAACTCCACC TAAGGCATGA ATATGCGGCA GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGCTGAG CAAAYITCCAC ACATGAGTAT TGTGCATGAG TAAATGAATA AAACA1TJ7GC AAAGACCTFr AGAGAAAGAG AATGGGAGCA TATGTGCGAA ATAAGATAGT TGATTATGAA TAGAAGGTAG TGAAGAAAAG CAAGCTAAGA AAAAATTCTG TTTATAAAAG AAGGAAAAGA TAGTTTATGT 1TUrAGCCTA AGTATAAGAG TCCTACAGAT GGACTGAAAA AAATCAGTCT GAGAGTATTA GTCACAATI'A ATGAAATAAT TACATM~AT GTATI7GAGGA TGCCAAGATT AAAAGGTGAC AGGTAGATGT TAATTTCCCT AGATTrGTGAA AGTGATCACG ACAATCACAC AACAAATAAT TAAGTGACYI7 GGTATGCITI7 ATI1AATGT AGGGCCTGAG GTI'TCCAYU CTCATTITC TAAAATACAA PTJ7G'TTCT CCAAATTTGA CAGCAGAATA AAAACCCTAC CCMIICACTG TGTATCATGC 155 TAAOCTGCAT CTCTACTCTT TACAOACTCT TAACCCTGGT GTATATGATA TCTCTTAT ACACAATUTA TGAATTT CCCAGGTCAO GCAOACACAG CTAAATTTCA ACTTCAATGT UTTCTTGCTC CATAACTACT TCCTTATGTA TTCTCAATTA GTTTGTGTTG GCATGCAAGA CCAAAOACCA AGAGCAGTTT CAACCCATAG GCAOAAAAGA AACAGAATGT AAGGAGAATC GATCATCTGT AGGTATTAAT TTACCAOOAC CTCTAOGAOT TTGAGTGAAT TTATATTGT CTCAAOATCA TTCTGAGAGT AGCACAATGC TGOOOTTCTC CATCUrCTCC ATOAAGACCA CACATGACUT CCATGGCATO GATGTUCACA GOATCCAATC TATATCTTTA CAGTTGTATA

CTATCCCACG

CCTOTA1TI7G

TTTAOGTACT

CTGAAGTCCT

GGATGTAGGA

ACCAGCGATG

AGTCAGTCCT

ATGCAGTATTF

TGCAATAAAT

TATCAAGATA

CCTrTTCATC

ACAATCACCA

TU-TGTGAAT

CACTCTTATT

ATCAUrGACT

TGCCCCACCC

TTCACAGTAT

CTGAATGAAC

GTATCATTAA

TGGAATAATG

ATGGGGAATT

AGCTCTTTAT

GCACACTCTA

AATTGATGGA

TACTTGGTAT

AATT-GGAAC

TTTGGTAATC

ACATATIFCT

TACCTGCCTT

CACTGCCCCA

ACCUUTCAT

TTATTAGTGT

TAACTTGATT

AAGGATCAA

CAAACAGAAC

TAAACAACCC

ATAGAGUTGA

GTAAACUOGA

AAAAGATTC

ACAAU7ACTT

TATACACAAC

TTATAOTACG

AATTGTCTTT

CCAGCCTTAA

GTTGTGACC

TCT'TATCTGT

TAAAATGATG

ACTCTATAAA

ATAGCCAOAA

AAOGAACTGG

GAAAGCTTUT

TAACGGTCT

AGTUTOTGT

AGCATGAOTC

TTCTCTUTGT

TTCTGTUCCC

TGAGATAGCA

AAGAAGTGAT

TCACGAGGTC

AAATTAGCCA

ATATTTGAGG

GAACGTCAOO

ATATTCTGTG

ACACGAATCA

GCNGGTCGTG

AOOAGATCGA

GGCGTGGTGG

TUTTACATCT GAAAATOAGA AUTGTTAAT AUTTAGGATT GAAGTAUTTG GTGGACATAT TU-CAAAGGA GTAGCTCTCC ACTTUOGGTA

GTGGCTCACG

OACCATCCTG

CGGOCOGCCT

CGTGTAATCC CAGCACTTTA OOOAGGCCAA OOCGGGTGOA GCTAACACGG TGAAACCGGG TGTCTACTAA AAAATACAAA TAOTCCCAG TACTCGGGAG GCTGAOOCAO GAGAATGGA TOAACCAGOO AGGCGOAGCT TGCCOTGAGC CGAGATAOCG CCACTGCAGT CGCTCCTGGG CAAAAGAGCA AGACTGCGTG TGAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTOTGTGGAG TAOCAGOACA CCTGCAACAA TAATA7TTU GTAAATGCCT CTGAAAAATO CTAATCAAAG GGTUFTTTTC CTAAAAATTG TCUTAGAAAT AAAATTTCCG GTTTGGGAGA CGGAGGCGO CAGATGACOA GGTCAGGAOA TAGAGACCAG GOTGAAACCC CGTCTCTACT AAAAATACTA AAAATTAGCCGOGGONOTOOT OGTGOGTACA CGTGTAGTCC CAGCTACUOG OAGGCTOAGG CTGGAGAATC ACOTGAAC-3' (FRAG. NO:J)(SEQ. ID NO:2504) Human Histidine Decarboxylase Nucleic Acid and Antisense Oligonucleotide Fragments CCC UTG GG TCT GGC TCC T[C TC TCT CTC TCC CTC TCT CTC TGT COG CTC COC CGT GOC TG TGG GGT GOT GOT GC UTT TGT TCT TCG TTG CTG CC GCC CCG GIG CUT GTG T TC GTC G CTC TGT CCC TCT CTC TCT GTB CTC CTC BOO GTC CBT CBT GTG CCT TGO GC-3'(FRAG. NO:1700) (SEQ. ID NO:1711) TCT GGC (FRAG. NO:1701) (SEQ. ID NO: 1712) UTG G (FRAG. NO:1702) (SEQ. ID NO: 1713) U TOT TCT ICC (FRAG. NO:1703) (SEQ. ID NO: 1714) TCT CCC UTG GG TGT GGC TCG UTC TC-31d (FRAG. NO:1024) (SEQ. ID NO: 1034) 5R- TCT CTC TCG CTC TCT CTC TGT -3D (FRAG. NO:1025) (SEQ. ID NO:1035) S0- GGC CTC CG CCT GG TG TOO GOT OGT OGT G-3D (FRAG. NO:1026) (SEQ. ID NO:1036) TU TOT ICT TCC U7G CTO CC-31i (FRAG. NO:1027) (SEQ. ID NO:1037) SD- 0CC CCO CTO CUT OTC T TG CTCG0-3D (FRAG. NO:1028) (SEQ. ID NO:1038) TOT CCC TCT CTG TCT 0Th CTC CTG BOO CTG CBT CBT GTC CCI TOO GC (FRAG.NO:1029)(SEQ.ID NO:1O39) Human Beta Tryptase Nucleic Acid and Antisense Oligonucleotide Fragments S'-CTU OCT CCT 000 GOC GTC CG GTC GCT CG GOT OTT CCC GOC 000 GCT GG CTG GOG CBO 000 CG COT BOO CG GG TCG GCB GOB COO 0GB GGG GB 0GB GB GB OBT TCB 0GCB TGC TOG-3' (FRAG.

NO:1 704) (SEQ. ID NO: 1715) OCT CCI 000 GOC CT-3' (FRAG. NO: 1705) (SEQ. ID NO: 1716) S-GTBOO GOG-3' (FRAG. NO:1706) (SEQ. ID NO: 1717) OG CTO 000-3' (FRAG. NO:1707) (SEQ. ID NO: 1718) OCT GGT 000 GG GTC CTG-3D (FRAG. NO:1030) (SEQ. ID NO:1040) 515-GTC GCT CG OOT OUT CCC OG-30 (FRAG. NO:1031) (SEQ. ID NO:1041) SD-OO0 CCT OG CG 000 CBO 0 GGO C COT BOO COC GGC TG GGB GOB COO GB GO GB 0GCB 0GCB 0GCB OBT TCB 0GCB TCC TOO-3D1 (FRAG. NO: 1032) (SEQ. ID NO: 1042) Human Tryptase-I Nucleic Acid and Antisense Oligonucleotide Fragments T GCT 00 GG GI CTO OT TC CCI CTG OCT 0 TI CCC GOG GGT GOB CTO 000 CG0 GGO C GT BOG CG GG TCO CGB 0GB COG 0GB 0GO CCB GB GB 0GCB OG 1GB GB ICC TOO CGB COO BBT TGC-3' (FRAG. NO: 1708) (SEQ. ID NO:1719) S'-GI GGT 000 OG CTG CG-31D (FRAG. NO:1709) (SEQ. ID NO:1720) TGG TOO GGB COO BBT TGG -3D (FRAG. NO:1710) (SEQ. ID NO:1721) S'-OGCGT C-3Di (FRAG. NO:1711) (SEQ. ID NO:1722) SD-CUT GT CCT 000 GG GIG CG-3D (FRAG. NO:1033) (SEQ. ID NO:1043) SD-GIG CGT CG 0GT 0 UT CCC GG-3R (FRAG. NO:1034) (SEQ. ID NO:1044) 50-GCT GOB CG 000 CG0 GG GOT BOO C0G OG G GGB GOB COO GB GG GB GB 0GCB 0GCB GG 1GB GB TGC TOG GGB COG BBT ICC -3D (FRAG. NO:1035) (SEQ. ID NO:1045) Human Prosta~landin D Synthase Nucleic Acid and Antisense Oligonucleotide 156 Fragments GTG CGG GGG CTG GTG CC CCI GGG CCT CGG GTG CTG CCT GT GCG CTG CGT TCT TGT CGT GG GIG CTG GCC GGG GCC CUT GCT GGG GIG GCT GT GCC GIG GGG GTC TGG GTT GGG CIG T CCC CBG CBG GBG CBG TGC GBT GGB GBG CGT GTG BIG BGT BGG GBT TGT CGT GCB GCC GBG-3'(FRAG.NO:1712)(SEQ.mD NO:1723) 5'-TTGT GCT GCBGCCGBG -3D (FRAG. NO:1713) (SEQ. ID NO:1724) S'-CUT GCT GCC CTG GCT GT-30 (FRAG. NO:1714) (SEQ. ID NO:1725) ICT TGT CCT GG-31] (FRAG. NO:1715) (SEQ. ID NO:1726) 51i-GGT GTG CGG GGC CTG GIGCC-3Di (FRAG. NO:1036) (SEQ. ID NO:1046) SD-CCT GGG CCT CGG GTGCGGCCT GT-311(FRAG. NO:1037) (SEQ. ID NO:1047) 51]-GCG GIG CCI ICT TCT CCI GG-3D (FRAG. NO:1038) (SEQ. ID NO:1048) SD-GIG GIG GGC GGG GCC CU7 GCI GCG GIG GCT GI-3D (FRAG. NO:1039) (SEQ. ID NO:1049) GIG GGG GIG TGG GUT GGG GIG I-3Di (FRAG. NO:1040) (SEQ. ID NO:1050) CBG CBG GBC CBG ICC GBT CCB CBG CGT GIG BIG BGI BGC GBT IGI CCI GCB GCG GBG -3Di (FRAG. NO:1041) (SEQ. ID NO:1051) Human Cyclooxygenase-2 Nucleic Acid and Antisense Oligonucleotide Fragments CGG GGG GGB GCB TCG C 'rrr GGG CUT TIC ICC UTT GGI T 1GB GGG CCB GGB GCG GGC BCB GCB GCB GGG GGC GGG CGB GCB IGG CBG CGG CGG GCB GGG-3' (FRAG. NO: 1716) (SEQ. ID NO:1729) GCB GGG -3Di (FRAG. NO: 1717) (SEQ. ID NO: 1730) S-ICCTTTfGGITI-3Di (FRAG. NO:1718) (SEQ. ID NO:1731) SD- GGG CGC GGG CGB GCB IGG C-3D (FRAG. NO:1042) (SEQ. ID NO:1052) SD- T GGG CUT TTC ICC Trr GGT I-3D (FRAG. NO:1043) (SEQ. ID NO:I053) SD-IGB GGG CCB GGB CCG CGC BGB GCB GCB GGG CGC GGG CGB GCB ICG CBG GGG CGG GCB GGG -3Di (FRAG. NO:1044) (SEQ. ID NO:1054) Human Eosinophil Cationic Protein Nucleic Acid and Antisense Oligonucleotide Frapaments CCT ICC IGG IGI GIG IGC CBG BCB BBT UTG GGB BGI GBB CBG UT TGG BBC CBT GUT ICC CBG ICT GIG BGC IGI GGC-3' (FRAG. NO: 1719) (SEQ. ID NO: 1732) ICC UTT GGI I-3D (FRAG. N 0:1720) (SEQ. ID NO: 1733) S'-I UC ICC U-T GGI I-3D (FRAG. NO:1721) (SEQ. ID NO:1734) SD- GGG CGC GGG CGB GCB TCG C-3D (FRAG. NO:1042) (SEQ. ID NO:1052) SD-T GGG CII TCICCT GGII-3Di (FRAG. NO:1043) (SEQ. ID NO:1053) GGG CCB GGB CCG CGC BGB GCB GCB GGG CG GGG CGB GCB TGG CBG CGG CGG GCB GGG -3D (FRAG. NO:1044) (SEQ. ID NO:1054) Human Eosinophil Derived Neurotoxin Nucleic Acid and Antisense Oligonucleotide Fragments S'-GCC GIG GIG GIG UrT GIG CT ICC CUT GGI GGG UTG GGC C GCI GGT IGI ICT GGG GTT C UTG GIG CCC CUT GIG ICC C IGI 110 GIG GIG ICT GCG C SD- CCC GBB GBG BBG BBG GBG BCB BBI U~G GGB BGT GBB CBG UTT IGG BBC CBT GUT ICC IGI-3' (FRAG. NO: 1722) (SEQ. ID NO: 1735) GIG I-3D (FRAG. NO:1723) (SEQ. ID NO: 1736) S-GIG UT GIG CI-3.D (FRAG. NO: 1724) (SEQ. ID NO:1737) S'-CG CC GGCC C-3D (FRAG. NO:1725) (SEQ. ID NO: 1738) SD- GCC GIG GIG GIG UTT GIG CT-3D (FRAG. NO:1047) (SEQ. ID NO:1055) SD- ICC CUT GGT GGG TIG GGC C-3Dl (FRAG. NO:1048) (SEQ. ID NO:1056) SD- GGI GGT IGI ICI GGG GTT C-3D (FRAG. NO:1049) (SEQ. ID NO:1058) SD- UTG GIG CCC CUT GIG ICC C-3D (FRAG. NO:1050) (SEQ. ID NO:1057) SD- IGI UTG GIG GIG ICI GGG C -3D (FRAG. NO:1051) (SEQ. ID NO:1059) SDl- CCC CBB CBG BBG BBG CBG BGB BBI UTG GGB BGT GBB CBG U-T IGG BBC CBT GTl ICC TGT-31D (FRAG. NO:1052) (SEQ. ID NO:1060) Human Eosinophil Peroxidase Nucleic Acid and Antisense Oligonucleotide Fragments GIG GGC GIG GIG CCG G GGG ICT CCI CUT GUT GU GC U-G CGC GIG GIG GIG GGG GI CC GIG IGI IGI IGI UFT GGG GGC GGG CCC GGC CGG IGI CII G GTT IGG GGG UTT CCG TIG GGG U7C ICC IGG CCC GGG CCI TGC CC GGC CGI GGI CCC GGC UTC GUGGIT GIG ICC GIG ICG GCI CUT GIG GGG CCI IGC GCI GIG UrT GGI G 50-GCB CCG ICC BGI GBI GGT GCG GIB CUT GIG GCT GCB GCG GIG GGC GIG GIG CG GBG BGC CACCOCICCI GICAGCCAAC AAAIAICCAT TGAGCGACAC CTGTGICCCA GGIGCTGCIC TGGGCCCIGG GAGAAGTGCA ICAGTGGGCI IGGIAGIAGA GGGIAGGGAT GGAGTGAAGG GTAGGCAGGA AGAATGTGCC CAGGCTGGTA GGAGGTGGGG TGGGGGGUTT CAGTCIGAAA ACICCCAIGA AAACCAGAGA GAAGUTTCAG AACTCCACCC AAGAGGCIGG GU-TCTAGGG CCCAGAGCIG CCCTCCCCCA CCCTAGAATG GGCTATAAAA GICCCU-CCC AGCIACGTCC AGAGAAGAGC TGGAGGAAGI GAGAGGICGG CIGGGGGTCG TCAAAGTGAG AGGGGAGCAG AGGAIGGICC CGIGCAGGCT GIGGAIGTCA CTCACUTCCC AGCTGOTGAA GCGTCGCTGC AGAGAIGGAT CIGCICCGAG CCCIGGCAGG GGTCCIGGCG ACACICGICC ICGCCCAGCC CTGTGAGGGC ACIGACCCAG GTAATAGICC CCTAGACAGG CAAGGAGGAG GGAGGGGAAA IGGAAGGGGA 157 AGCACTTGGG TCTTGGAGGG GGTCTTGTGG CTTGCTGAAC CCTGAGTCCC CATCTCTTTG AACAGCCTCC CCTGGGGCAG TGGAGACCTC GGTCCTGCGA GACTGCATAG CAGAGGCCAA GTTGCTGGTG GATGCTGCCT ACAATTGGAC CCAGAAGAGG TGGACTTGGG TCTGGGGGCT GCATGGGCCT GGGAGGATCA GT TAATACCTTG TGGGGTCAGG GAGCCCATGT CCCGTGCTGA TGTTATTTCC TGTGCGCT-fc CCCAATGAGA GACTGACCTC CGACCGTGGC UTCATTGACC ATGACCTGGA CTTCTCCCCG GAGTCCCCGG GTGAGAGGAC CTGCGCCCAG CTGCCCCCCT GCTTTCCCAT GCCCT-rGTGT GGCCTCCCCC AAAGGCAAGG TGCTGGGGGT

CCACCAGGTC

CGAGCCCTCA

CCAGAGTGGC

CAAGGTACCT

GGGGATCTGG

CGGGCTGTCT

TGTTCATGCA

CTTCACTGCA

ACCCTCAGCC

AAGACTGGAG

CACTGTCTCC

1TTCTTCCGC

TCCTTTGTGG

ACTACCTGGG

CCTGCACGAT

CCAACCAGAT

GTGGGGCCAG

GGCG'rrGACT

AATCTCCCAT

CACCATCCTT

TCTTCCATCT

TCGGCACCCT

ACGCCAGCAT

GCTGCTGGCC

GACCCCTGTC

AAGGAGCTGC

CAGATCCCAC

CATGCCCCCA

GGTGTATGGC

ATCAACCAGC

TCCTCACCAA

CCAGGAAACA

CTGTGGAGCT AGGGTATGAG ACAGAGACAC AAG CCAATGACCC CCGCATCAAG AACCAGCGTG ACTGCATCCC AAACAAGAAC AGAGTCCGCA ACCAGATCAA CGCGCTCACC AGTGAGGTCT CCCTCTCGCT GCGGCTCCGC AACCGGACCA GCTTTCAAGA CAACGGCCGG GCCCTGCTGC CCTrCGACAA CCGCTCGGCG CGCATCCCCT GCTTCCTGGC AGGTCAGACA GGGAGGAAGG TGGTGTC1TC GCCATCCCTG GGGTCCCAAC TGGGAAGCAA TGGTGGGATG TGGTGAAGGT ACATGGTG GGACCTCAGT ATTAGOCACA CCATAAGCAT GGATCTGTGC AC TGAAGAGATG GAGGTCCAGT GAGGGCCAGG AGTTTrGGCCC ACCCCGTCTC TCCCATCCCC AGCCCTGGGT CTACCCTGGT AGAAAGACAT TITCTCTGGGA AAGGCTGCAG TAAATCTGAG CTTGGGGTTT TCAAGGTGAC ACCCGATCAA CGGAAACCCC CAAACTGGCA GCCATGCACA CCCTC1TTAT GCGAGAGCAC AACCGGCTGG CCACCGAGCT GAGACGCCTG AATCCCCGGT GGAATGGAGA CAAACTGTAC AATGAGGCTC GGAAGATCAT GGGGGCCATG GTCCAGGTAA GGAGCTCTGC ATCCCAGCAT CCCCC CTTTGTATCT CCACCCACCA ATAGTAAATT AATGTTGTCA CATTTGACGT GATGACAATA AAGAATATGT CTGAGCCACC CT17GAAAAG GCAAGGGTAT GGGTGAGTAG CCTCTGGGGA ATGTfCCTCC TGTCT7CCCT TCCAGATCAT CACCTACCGA GAC1CTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC C'rrCCGCTTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC T-rC1TrGCCA GCTGGCGGAT CGTGTATGAA GGTGACCAGG YTfCCAGGG GGCAAATGGG GGTGAGGGTG GGGAGCATGC CCTCCCCTAG GTGG TCCAGCTGCT TCATGTCTCT CCAGAACTCT GTTTCCTGAC AAACGTTACT AACATACCCG ACTGGCTTGT CCAGCTCTGG GCTAGCTTGG CATCATGTGA TAACCCAAGT AGCTTCCCAG AGGCTGGTCC AATCTGTGCT GCTCACATTC CCTGCCACCA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTG'TTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGTGAGGGG GCTGTCCACC TCTTCTCCCA GCTITGCTCG GGCCAGGCTG CTCAAGGGGT TCTGGGAAGA CCCTGGTACC CGACTGCCTG GTAGGTTCTG GTGGCAGAAA CGAGGTGTTT TCACCAAAAG ACAGCGCAAG GCCCTGAGCA GAAT-rTCCTT GTCTCGAATFT ATATGTGACA ATACCGGTAT CACCACGGTT TCAAGGGACA TCTTCAGAGC CAACATCTAC CCTCGGGGCT TTGTGAACTG CAGCCGTATC CCCAGGTTGA ACCTATCAGC CTGGCGAGGG ACATGAGGCT TCTGCAGGTA AGGGGAGGCC ACCTCCAGCA CCCTGGGCTG GTTAAGCCTC ACATCC11TCC CTGGATGGAT GGCTGAGTCC TCTTAGGTCT CTAAGCAGAG AAAACAGAAC TTrGTCACTAG GTACTCYFTC CAAGTGGCTT CCCAATGTGC TAGTJ7TCTGG GCTGACAGTC AAT-rCCAGGC CCTAGGACTT TGGGGGGAAA UTAGGAGCAT CCAACTA GAATTCCGTG GCCAGGACCC CTGCCAGGGC ACTGACCCAG CCTCCCCTGG GGCAGTGGAG ACCTCGGTCC TGCGAGACTG AGAGCATCAA GCAGCGGCTT GGTAGCAGCC ACCAGGACAG AAGTTACAAC CCCAGCGGTC TGTCCCAGGC CAGTGGCTGT TGGACGGTGC AACAACAAGA GCCGAGTATG AGGATGGGCT TCCCTCTTGT CCGGGCTGTC

CATAGCAGAG

CGCAGCGGTT

'FrGTTCGGGC CGGACCCT-rC

GCTCTCCGGG

GGAGACCCTT

GTCGCTCCCC

TCCAACCAGA

AGTGGGGCCA

AGGCGTTGAC

CCCCGCATCA

ACAGAGTCCG

GCCAAGTTGC TGGTGGATGC CAGCCAGCCC CATGGACCTC CGCAGATTAT ATGCATGTGG ATTGTCACTG ATGTGCTAAC ACCAGGCCGA GCGCTGCAGC GCTAGGGGCC TCCAACCAGG TITCGGCTGGA CCCCCAGCAG TGTGCGCTT CCCCAATGAG GTTCATTGAC CATGACCTGG TGTGAGAGGA CCTGCGCCCA AGAACCAGCG TGACTGCATC CAACCAGATC AACGCGCTCA

CCGAGCCCTC

GCCAGAGTGG

TCAAGATCCC

CTCATGCCCC

ATGGTGTATG

CCATCAACCA

TCTCCTCACC

AAACTGGCAG

ATCCCCGGTG

CACCTACCGA

GGGTACTGCT

TGCTCCAGCC

TAGCTCTGCC

ATGGCCACCC

GGCAAGTGAG

AGGGTACAAT

CTGAAAAACC

TTrGGGGCCAT

CCAGTTCAGA

ATGTTCATGC

CCTTCACTGC

ACCCAATGAC

CAAAACAAGA

GCAGTGAGGT

GCGC'TrTCAA

AACCGCTCGG

CCATGCACAC

GAATGGAGAC

CTCCCTCTCG CTGCGGCTCC GCAACCGGAC GACAACGGCC GGGCCCTGCT GCCCTTCGAC CGCGCATCCC CTGCTTCCTG GCAGGTGACA CCTCTI1TATG CGAGAGCACA ACCGGCTGGC AAACTGTACA ATGAGGCTCG GAAGATCATG TGCCTACAAT TGGACCCAGA CTGTCCTACT TCAAACAACC CTI1700GGCT GCTTGAAGAG AGAACCACAG CTGCGGCTGC GACAAGTACC GCACCATCAC CTCTGGCTCG CTGGCTGCCC GAGGCGCAAT GGCTTCCYJTC AGACTGACCT CCGACCGTGG ACTrCTCCCC GGAGTCCCCG GCTGCCCCCC TGCMrCCCA CCTTrCTrCC GCTCGGCACC CCTCCfTTGT GGACGCCAGC CAACTACCTG GGGCTGCTGG AACCTGCACG ATGACCCCTG CCCGATCAAC GGAAACCCCC CACCGAGCTG AGACGCCTGA GGGGCCATGG TCCAGATCAT GAACCCTGGG GCACTACAGG CTrCCGCTTT GGCCACACAA CCCAACTCGC ATGTCCCACT ACCCCATCCT CCGGOCCTC GCTCCGGGAC CGGCTGTFITC AGCCGGGACC ACGGCCTTCC TGGCACAGCT TAGCCGGGTG TGACAACATF GACATCTGGA CTGGCTTGTC TGTTCGAGAA GAC1TTCTGC CCCTGGUTCT GGGCAAGGCC CGGGCCAGGA CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC

CTTFCATGTTC

TITCTTJTGCCA

CTGCCAAGCT

GAGGATTGGG

GCTTGGAGGC

AGGACTTGGC

CGCTGAGCCT

CGCT[GGACA

GCTGGCGGAT

GAACCGTCAG

CTGGACCTGG

GCTTCTGTGG

AAGGAAGTTC

CT-rTTGCCGG

GTCAGTACCG

CGTGTATGAA

GATGCCATGT

CAGCTCTCAA

GCTCTCCCAG

CTGAAT'fTGT

GGGCTCGAGT

GGCCTCCGCA

GGGGGCATCG

TAGTGGATGA

CATGCAACGA

CCCCGGAATr

ATGGAACACC

GGGGCCTCTT

AGAGCCGAGA CGGAGACAGG TTCTGGTGGC AGAACGAGGT GTTTTCACCA AAGACAGCGC 158 AAGGCCCTGA GCAGAATTTC CTrGTCTCGA ATTATATGTG ACAATACCGG TATCACCACG G1TrCAAGGG ACATCT-rCAG AGCCAACATC TACCCTCGGG GCTTTGTGAA CTGCAGCCGT ATCCCCAGGT TGAACCTATC AGCCTGGCGA GGGACATGAG GCTTCTGCAG GAGTCTATCC CAAGTCTCCA ACTTTrGGAG ACAAGGGGAA GGGGAGGACC ATGAGGCTGC CTTGTCTCCC TGGAGCAAGT GCAGGCTCGT GACGCTTrCTG CTGGCTACAG CTCAGAGCTG GGTTCCCCAG CCAGGAGTGA AGGCTGGGGG CTCCTATCAG CAATGGACCT TCCGCCTTGG GAGCCTCYI'A GGTATJTAGGC TATGAATCAG CGCCACGTGC AAAGGCTTGG GAGCCAAGCC ATGTGGTCTTr GCACCCCAGG CAAGAAAAGT CAGCTGGAGG GTT-rACAGCA CTTCTACTG TTTCCCAGCC CTCCCTCCCC TCCCTCACCA TGACTAAGAG ACCACTCGGT CCTAGCCTCC AGACACCCCA CAATACTCCT CTGAGCCTGA GGCCAGGCAG CATGCTCTGC TJTCTACCAAT AAAGCACTGC CGGAATTC-30 (FRAG. NO: 1726) (SEQ. ID NO: 1 0 3008) GTCAGCCAAC AAATATCCAT TGAGCGACAC CTGTGTCCCA GGTGCTGCTC TGGGCCCTGG GAGAAGTGCA TCAGTGGGCT TGGTAGTAGA GGGTAGGGAT GGAGTGAAGG GTAGGCAGGA AGAATGTCCC CAGGCTGGTA GGAGGTGGGG TGGGGGGTTT CAGTCTCAAA ACTCCCATGA AAACCAGAGA GAAGTTTCAG AACTCCACCC AAGAGGCTGG GTTTCTAGGG CCCAGAGCTG CCCTCCCCCA CCCTAGAATG GGCTATAAAA GTCCCTTCCC AGCTACGTCC AGAGAAGAGC TGGAGGAAGT GAGAGGTCGG CTGGGGGTCC TCAAAGTGAG AGGGGAGCAG AGGATCCTCC CGTGCAGGCT GTGGATGTCA CTCACTrCCC AGCTGGTGAA GCCTCGCTGC AGAGATOCAT CTGCTCCCAG CCCTGGCAGG GGTCCTGGCC ACACTCGTCC TCGCCCAGCC CTGTGAGGGC ACTGACCCAG GTAATAGTCC CCTAGACAGG CAAGGAGGAG GGAGGGGAAA TGGAAGGGGA AGCACTTGGG TCTTGGAGGG GGTCTTGTGG C17GCTGAAC CCTGAGTCCC CATCTCTTTG AACAGCCTCC CCTGGGGCAG TGGAGACCTC GGTCCTGCGA GACTGCATAG CAGAGGCCAA GTTGCTGGTG GATGCTGCCT ACAATTGGAC CCAGAAGAGG TGGACTTGGG TCTGGGGGCT GCATGGGCCT GGGAGGATCA GT-3' (FRAG. NO:J)(SEQ. ID NO:2483) '-TAATACCTTG TGGGGTCAGG GAGCCCATGT CCCGTGCTGA TGTTAT-17CC CCACCAGGTC CGGGCTGTCT CCAACCAGAT TGTGCGCTTC CCCAATGAGA GACTGACCTC CGACCGTGGC CGAGCCCTCA TGTTCATGCA GTGGGGCCAG TTCATTGACC ATGACCTGGA CTTCTCCCCG GAGTCCCCGG CCAGAGTGGC CTTCACTGCA GGCGT7GACT GTGAGAGGAC CTGCGCCCAG CTGCCCCCCT GCTrTfCCCAT CAAGGTACCT ACCCTCAGCC AATCTCCCAT GCCCT-rGTGT GGCCTCCCCC AAAGGCAAGG TGCTGGGGGT GGGGATCTGG AAGACTGGAG CACCATCCTT AAGGAGCTGC CTGTGGAGCT AGGGTATGAG ACAGAGACAC AAG-3' (FRAG.NO:_9(SEQ.ID NO:2484) 5'-CACTGTCTCC TCTTCCATCT CAGATCCCAC CCAATGACCC CCGCATCAAG AACCAGCGTG ACTGCATCCC TTTCTTCCGC TCGGCACCCT CATGCCCCCA AAACAAGAAC AGAGTCCGCA ACCAGATCAA CGCGCTCACC TCCTTTGTGG ACGCCAGCAT GGTGTATGGC AGTGAGGTCT CCCTCTCGCT GCGGCTCCGC AACCGGACCA ACTACCTGGG GCTGCTGGCC ATCAACCAGC GCTTTCAAGA CAACGGCCGG GCCCTGCTGC CCTrCGACAA CCTGCACGAT GACCCCTGTC TCCTCACCAA CCGCTCGGCG CGCATCCCCT GCTTCCTGGC AGGTCAGACA GGGAGGAAGG TGGTGTCTTC CCAGGAAACA GCCATCCCTG GGGTCCCAAC TGGGAAGCAA TGGTGGGATG TGGTGAAGGT ACATGG1TTG GGACCTCAGT A~rAGGCACA CCATAAGCAT GGATCTGTGC AC-3' (FRAG.NO:J)(SEQ.ID NO:2485) GAGGTCCAGT GAGGGCCAGG AGTJ7TGGCCC ACCCCGTCTC TCCCATCCCC AGCCCTGGGT CTACCCTGGT AGAAAGACAT Y[rCTCTGGGA AAGGCTGCAG TAAATCTGAG CTTGGGGTTr TCAAGGTGAC ACCCGATCAA CGGAAACCCC CAAACTGGCA GCCATGCACA CCCTCTTTAT GCOAGAGGAC AACCGGCTGG CCACCGAGCT GAGACGCCTG AATCCCCGGT GGAATGGAGA CAAACTGTAC AATGAGGCTC GGAAGATCAT GGGGGCCATG GTCCAGGTAA GGAGCTCTGC ATCCCAGCAT CCCCC-3' (FRAG.NO:_J(SEQ.IDNO:2486) CCACCCACCA ATAGTAAATT AATGTTGTCA CATTTGACGT GATGACAATA AAGAATATGT CTGAGCCACC CTTTGAAAAG GCAAGGGTAT GGGTGAGTAG CCTCTGGGGA ATGTTCCTCC TGTCTTCCCT TCCAGATCAT CACCTACCGA GAC1TTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CT1TCCGCTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TrCTFrGCCA GCTGGCGGAT CGTGTATGAA GGTGACCAGG TTICCAGGG GGCAAATGGG GGTGAGGGTG GGGAGCATGC CCTCCCCTAG GTGG-3' (FRAG.NO:j)(SEQ.ID NO:2487) 5'-TCCAGCTGCT TCATGTCTCT CCAGAACTCT GTTTCCTGAC AAACGTrACT AACATACCCG ACTGGCTTGT CCAGCTCTGG GCTAGCTTGG CATCATGTGA TAACCCAAGT AGCTTCCCAG AGGCTGGTCC AATCTGTGCT GCTCACATTC CCTGCCACCA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTG1TTTC GGCAAGTGAG GAGGATrGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTrCC AGGTGAGGGG GCTGTCCACC TCTTCTCCCA GCTTTGCTCG GGCCAGGCTG CTCAAGGGGT TCTGGGAAGA CCCTGGTACC-3' (FRAG.NO:J(SEQ.ID NO:2488) GTAGGT-rCTG GTGGCAGAAA CGAGGTG1T TCACCAAAAG ACAGCGCAAG GCCCTGAGCA GAATTTCC'rr GTCTCGAATr ATATGTGACA ATACCGGTAT CACCACGGTTr TCAAGGGACA TCTTCAGAGC CAACATCTAC CCTCGGGGCT UTGTGAACTG CAGCCGTATC CCCAGGTTGA ACCTATCAGC CTGGCGAGGG ACATGAGGCT TCTGCAGGTA AGGGGAGGCC ACCTCCAGCA CCCTGGGCTG GTTAAGCCTC ACATCCTI7CC CTGGATGGAT GGCTGAGTCC TCT-rAGGTCT CTAAGCAGAG AAAACAGAAC TTGTCACTAG GTACTCTTTC CAAGTGGCTT CCCAATGTGC TAGTTTCTGG GCTGACAGTC AATTrCCAGGC CCTAGGACT[ TGGGGGGAAA TITAGGAGCAT CCAACTA-3' (FRAG.NO:j(SEQ.ID NO:2489) GCCAGGACCC CTGCCAGGGC ACTGACCCAG CCTCCCCTGG GGCAGTGGAG ACCTCGGTCC TGCGAGACTG CATAGGAGAG GCCAAGTTrGC TGGTGGATGC TGCCTACAAT TGGACCCAGA AGAGCATCAA GCAGCGGC'17 CGCAGCGGTT CAGCCAGCCC CATGGACCTC CTGTCCTACT TCAAACAACC GGTAGCAGCC ACCAGGACAG TTGTTCGGGC CGCAGATTAT ATGCATGTGG CTrTGGGGCT GCTTGAAGAG AAGTTACAAC 159

CCCAGCGGTC

CAOTGGCTGT

AACAACAAGA

AOGATGGGCT

CCGOOCTGTC

ATGTTCATOC

CCUTCACTGC

ACCCAATGAC

CAAAACAAGA

GCAGTOAGGT

GCGCTTUCAA

AACCGCTCGO

CCATGCACAC

CGGACCCTTC ATTGTCACTG ATGTGCTAAC AGAACCACAO CTGCGGCTGC GCTCTCCGGG ACCAGGCCGA GCOCTGCAGC GACAAGTACC GCACCATCAC GGAGACCCUT GCTAGGGOCC TCCAACCAGG CTCTGGCTCG CTGGCTGCCC GTCGCTCCCC TTCOOCTGGA CCCCCAGCAO GAGGCOCAAT GGCTTCCTTC TCCAACCAGA UTGTGCGCTT CCCCAATGAO AGACTGACCT CCGACCGTOO AGTGOGCCA GUTCATTGAC CATGACCTO0 ACTTCTCCCC GGAGTCCCCG AGGCGTTGAC TGTGAGAGGA CCTGCGCCCA GCTGCCCCCC TGCTCCCA CCCCGCATCA AGAACCAGCG TGACTGCATC CCTTTCTTCC GCTCGGCACC ACAGAGTCCG CAACCAGATC AACGCGCTCA CCTCCTTTGT GGACGCCAGC CTCCCTCTCG CTGCGGCTCC GCAACCGGAC CAACTACCTG GGGCTGCTG GACAACGGCC GGGCCCTGCT GCCCTTCGAC AACCTGCACG ATGACCCCTG

TOTCCCAOOC

TGGACGGTGC

GCCGAOTATG

TCCCTCTTGT

CCGAGCCCTC

GCCAGAGTGO

TCAAGATCCC

CTCATOCCCC

ATOOTGTATG

CCATCAACCA

TCTCCTCACC

AAACTGGCAG

ATCCCCGGTG

CGCGCATCCC CTGCTTCCTG GCAOGTOACA CCCGATCAAC CCTCTTTATG COAGAGGACA ACCGGCTGGC CACCGAGCTG

GGAAACCCCC

AGACGCCTGA

GAATGOAGAC AAACTGTACA ATGAGGCTCG GAAGATCATG GGCCATGG TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGOCCAGGA GAACCCTGGG CCAATGTGGA CCCACGGGTG OCCAATGTCT TCACCCTGOC CUICATGTTC CGCTTGGACA OTCAOTACCG U-CUTOTCCA GCTGGCGGAT CGTGTATGAA

CTGCCAAGCT

GAGGATTGGO

GCTTGOAGGC

AOGACTTFGC

CGCTGAGCCT

AGAGCCGAGA

GCAGAATTUC

AGCCAACATC

GGGACATGAG

ATOAGGCTGC

GTTCCCCAO

GOTATTAGGC

CAAGAAAAGT

TGACTAAGAG

GAACCGTCAG GATGCCATOT CTGGACCTOG CAGCTCTCAA GCUTCTGTGG OCTCTCCCAG AAOOAAGTTC CTGAATT CTT7TGCCGG GOGCTCGAOT

GGCCTCCGCA

GGGGGCATCG

TAGTGGATGA

CATGCAACGA

CCCCGGAATT

ATGGAACACC

GGGGCCTCTT

CTTCCGC1TI7

CCCAACTCGC

ACCCCATCCT

GCTCCGGGAC

AGCCGGGACC

TOGCACAGCT

TGACAACATU

CTOGCTTGTC

GTTTTCACCA

TATCACCACG

ATCCCCAGGT

GCACTACAG

GGCCACACAA

ATGTCCCACT

CCGGGGCCTC

CGGCTGTTTC

ACGGCCUTCC

TAGCCGTG

GACATCTGGA

TGTTCGAGAA

AAGACAGCGC

GTTTCAAGGG

TGAACCTATC

GGGTACTOCT

TGCTCCAGCC

TAGCTCTGCC

ATGGCCACCC

GGCAAOTGAG

AOGGTACAAT

CTOAAAAACC

UTGGGGCCAT

CCAGTTCAGA

AAGGCCCTGA

ACATCTTCAG

AOCCTGGCGA

CGGAGACAGG TTCTGGTGGC AGAACOAOGT CUOGTCTCGA ATTrATATGTG ACAATACCG TACCCTCGOG OCUTTGTOAA CTGCAGCCGT GCTTCTGCAG GAGTCTATCC CAAGTCTCCA CTT7GTCTCCC TGGAGCAAGT GCAGOCTCGT CCAGGAGTOA AGGCTGGGGG CTCCTATCAG TATGAATCAG COCCACGTGC AAAGGCTTGG ACTrrTGGAG ACAAGGGGAA GGGGAGGACC GACGCTTCTO CTGOCTACAG CTCAGAGCTG CAATGOACCT TCCGCCUOOG GAGCCTCTTA GAGCCAAGCC ATGTGGTCTT GCACCCCAGG CAOCTOGAGG GUTTACAGGA CTTTCTACTG UTTCCCAGCC CTCCCTCCCC TCCCTCACCA ACCACTCGGT CCTAGCCTCC AGACACCCCA CAATACTCCT CTGAGCCTGA OGCCAGGCAG CATGCTCTGC TTCTACCAAT AAAGCACTGC CGOAATTC- 3' (FRAG.NO:_) (SEQ. ID no:2490) GOC CTO OTC CCG G-30 (FRAG. NO: 1727) (SEQ. ID NO:1740) 5'-TGG GGG UTT CCG TTG-3D (FRAG. NO: 1728) (SEQ. ID NO: 1741) OTC CCG GBG BGC -Al (FRAG. NO: 1729) (SEQ. MD NO: 1742) SD-GCG CTC GGC CTG GTC CCG G-30 (FRAG. NO:1053) (SEQ. ID NO:1061) SD-GGG TCT CCT CUT GTT GTT GC-30 (FRAG. NO:1054) (SEQ. ID NO:1062) S1]- U-G CGC CTC CTG CTG GGG OT CC-3D (FRAG. NO:1055) (SEQ. ID NO:1063) 5D-CTC TOT TCT TGT TTT GGG GGC-3D (FRAG. NO:1056) (SEQ. ID NO:1064) CCC OGC COT TOT CTT G-30 (FRAG. NO:1057) (SEQ. ID NO:1065) TGG 000 UTT CCG TTG-3D (FRAG. NO:1058) (SEQ. ID NO:1066) TTC TCC TOG CCC 000 CCT TOC CC-3D (FRAG. NO:1059)(SEQ. ID NO:1067) SD-OOC COT GGT CCC GGC TTC GUT GC-3D (FRAG. NO:1060) (SEQ. ID NO:1068) 5U-CCT GTC TCC GTC TCG OCT CUT CTG-3D1 (FRAG. NO:1061) (SEQ. ID NO:1069) CCT TOC OCT GTC TTT GGT 0-3D (FRAG. NO:1062) (SEQ. ID NO:1070) CCO TCC BOT GBT GOT OCG 0TB CUT GTC OCT GCB GCG CTC GGC CTG GTC CCG GBO BOC -3Di (FRAG. NO:1063) (SEQ. ID NO:1071) Human Intercellular Adhesion Molecule-i (ICAM-1) Nucleic Acid and Antisense Oli~onucleotide Fragments COO 0CC 000 OOC TOC TOO 0 GOT TOO CCC 000 OTO CCC C 0CC OCT 000 TOC CCT COT CCT CTO COO TC OTO TCT CCT OOC TCT GOT TCC CC OCT OCO CCC GUT OTC CTC TOO GOT GOC CUT C OCT CCC 000 TCT GOT TCT TOT OT TOO 000 TCC CU T 000 CCT OUr OT OGC OTO OCT TOT OTO UTC GOT UTC TOC CCT OTC CTC COO COT CCC COO BOC CTC CCC 000 GCB GOB TOB CUT UG BOO 000 BCB CBO BTO TCT 000 CBT TOC CBO OTC CTO 0GB BCB OBO CCC COB GCB GOB CCB 0GB OTO COO OCB OCO COO OCC 000 OOC TOC TOO OBO CCB TBO COB GOC TOB 0-3- (FRAG. NO: 1730) (SEQ. ID NO: 1743) 5'-000 OC TOCTOO 0-3D] (FRAG. NO: 1731) (SEQ. ID NO:1744) OTC CTC COO COT CCC-3D (FRAG. NO:1732) (SEQ. ID NO:1745) CCB TBO COB GOC TOB 0-3D (FRAG. NO: 1733) (SEQ. ID NO: 1746) 5'-CTC TOO GTOOC CUC-3D (FRAG. NO:1734) (SEQ. ID NO:1747) SD-GCO COO OCC 000 GOC TOC TOO 0-3D (FRAG. NO:1064) (SEQ. ID NO:1072) SD-GOT TOO CCC 000 OTO CCC C-3D (FRAG. NO:1065) (SEQ. ID NO:1073) SD-OCC OCT 000 TOC CCT COT CCT CTO COO TC-3U (FRAG. NO:1066) (SEQ. In NO:1074) TCT CCT GOC TCT GOT TCC CC-3D (FRAG. NO:1067) (SEQ. ID NO:1075) SD-OCT OCO CCC GUr OTC CTC TOO GOT GOC CUT C-3D (FRAG. NO:1068) (SEQ. ID NO:I076) SD]-OCT CCCG000TCTGOGT TCT TOTGT-30 (FRAG. NO:1069) (SEQ. II)NO:1 077) 160 SD-TGOGGTCC C-Fr rrGGGCCT OTT GT-3D i(FRAG. NO:1070) (SEQ. ID NO:1078) GTG GCT TGT GTG ITC GGT TTC-3U (FRAG. NO:1071) (SEQ. ID NO:1079) CCT GTC CTC COG GGT CCC-3D (FRAG. NO:1072) (SEQ. ID NO:1080) COG BGC CTC CCC GOG GB GOB 1GB CTT TTG BGG GGG BCB GBG BTG TCT GGG GBT TGG CBG GTC CTG 0GB BCB GBG CCC CGB GCB 0GB CCB GOB GTG COG GCB GCG CGO GCC GGO GGC TGG TOG GBG CB T13G COB GOC TGB 0-3D (FRAG. NO:1073) (SEQ. ID NO:1081) Human Vascular Cell Adhesion Molecule 1 (VCAM-1) Nucleic Acid and Oligonucleotide Fragments CIT TTG TOT TTT TCC C CTC TG CIT TOT TO GGT TCO CTT CCT TC TGC TTC ITC C CTG TGT CTC CTG TGT CG CIT TT TCT IC GTC TIT GTT GIT TG TGT TCC TO CG BGC BBG BIB TCT BGB TG TOO GGT GOT CIC OBT ITT BBBB OCT 1GB 0DB OCT GCB BBC BIT BTC CBB BOT BIB ITT OBO OCT CCB BOO BTC BCG BCC BTC ITC CCB GOC BIT ITB BOT TG TOT COT-3'(FRAG.NO: I735)(SEQ.ID NO: 1748) TOT COT-3- (FRAG. NO:1736) (SEQ. ID NO:1749) TIC ITC C-30 (FRAG. NO:1737) (SEQ. ID NO:1750) HSVCAM I ASI: 5D-CGT CIT TTC TOT T ICC C-30 (FRAG. NO:1074) (SEQ. ID NO:1082) HSVCAMIAS2: 5D-GTC TGCI-TTTITO GTIG-3D(FRAG. NO:1075) (SEQ. ID NO:1083) HSVCAMIAS3: SD-CITrGCTTITGT ITTCC-3D (FRAG. NO:1076) (SEQ. ID NO:1084) HSVCAMIAS4: 5U-GTG TOT CIC CTO TCT CG CIT ITT TGT TC-3D (FRAG. NO:1077) (SEQ. ID NO:1085) HSVCAMI AS5: 5D-OTC TIT OTT OTT ITC TCT ICC TO-3D (FRAG. NO:1078) (SEQ. ID NO:1086) CG BG BBO BIB TCT BOB TC 100 001 GOT CTCGOBT TIT BBBB OCT TOB 0DB OCT GB B3BC BT BTG CBB BOT BTB TT OBO OCT GGB BOO BIG BCO BCC DTC ITC CCB GOC BIT7 ITB BOT TG TOT COT(FRAG.

NO: 1079)(SEQ. ID NO: 1087) Human Endothetial Leukocyte Adhesion MoleculefELAM-1) Nucleic Acid and Antisense Oligonucleotide Fragments 5'-BBG TOB OBO CTO BOB 0DB BCT OTO BBG CDD TCB TOB CIT CBB ODO ITC TT TGB CCC OTT CIT GOC ITC TTC TOT C COT TOO CIT CTC GIT GIG CC 101 000CT CIT GOTT GIG CC CCC ITC 000 GOC TOG TG GOC COT CGT TG CTO CTO 0 OTT CIT GOC TG TTG TOT CCO T TOG CIT GTC OTT OTC CC TOT 000 GTT CTCGOTT OTC CC GCC ITC 000 GG TOG TOO GOC COT GGT TG CG T G0 CCTOAOACAO AGOCAGAOT OATAGCCACC TGAOAOATCG TTGGOTGAA AAOAACTCT CATIAAAGAO AOTOOAGCCT TATOTCAOG AAAOGTACAG TATOAGGIA ITCACCAAOT AAGCCAOAAA CITCOAGAOG OAOGACTGCO IOOAOATCTA AOAAOAAGCT IOCCCIATGG AOAOACCATC AATAAITACA AAGTGTACAO CCCTOOAATC ACAAITGTGr CTGICTATG OTGGTCTOOA OAATOOAOTO GGAATOOOT TCOTOOAATO OTGAAOAAOG AITTGAAGTA OAAGCCAACO TGTAAAGTO CATICGCTO CTOOAOAIT AGGGAGGAGC CCAOGTTGAA CCAOTOCACA OCCTTOTCCA GITATGOT CCAGCTGTOA OTGOCGCCAC AOOOOAOTOO OCCCCOGAAO OITTOOTOA TGAGCTGTG AGOAGOGAIT IOITTOAA CAACTGGITC CGAAAACOGA OAAGTGATOA TGTTGACA OTTCTCTCA OOTCTAGAA CACCTCCAG GAAOCIATOA AGACCTOOIT OCAAITCAAA ACAAAGAAGA

TATIACTOGA

AAOAAGCCAA

CAICAAOAOA

TACAGAGCGG

CTTGCAAGTO

GCCTGAGA

AGCTOIOATA

CIGCTAITCG

ITTCCAAAAC

TTOOAATCAO

GAAGTGGOCT

GAAAAAGATG

CCTGTAGCAA

IGACGCTOOC

OGAAOGCCTOO

OOOIGGTC

AGGCAAT

CCTGGAAGCT

AAAAGTCAAC

CCAGOTOAAC

TGOCATOTO

TAGATCGTGG

TGAGTOOAC

TTGAGICA

GCCAAGGAGC

OTGITOAGI

TCCCATOGAA

OTOTACGTCA

CAOCCTGAGA

AGTCAGCTG

AAGIAITTCA AOCGTAAACC OCTCTGACTT IOOTGCTTCT CITAIOATOA OGCCAOTGCT OATOAGTAC CTAAAGTCGA AATGIGTGGO TCTOOOTAOO CCAACAATAG GCAAAAAOAI OAATOATGAG AGOTOCAGGA AGTOGCAG GTGAATGTGT TCAAGIOTGA GCAAATTGTG CCCACTGGOA AAGITCAGGT ATOGAGAGGA TOCAOTGTAT OTOATOCTOT GACAAATCGA CACAACCTGT AGATTOACT TCTOOOAATI OOOACAACOA ATOGTCTGI GAOOIOCAOC TGAGGAAGGC TGATGITOC ATOOOAGGCC AOAGCTTCA TOACATGAG OOCCOTCCOC CACCITCAAA IGAIGGIOCA TGGACCACTC AAOGAOTG ACCCGAGO AOGTAGATO OACAGAGCAA ATCCGAGITTT GTGAAGGTIT AAITGTGITC CTAOTOCITG TGGCAGTTTC OTGCCTGT GAGCAGOGIT TTOTOAA GGGAICGAAA AOGTCCAAI GAGAACGAGA AOCCCACATG TOAAGGTGTO AGATOCOATO CTOTGGAGCA

OOTOIOCTCA

TGAAITATAT

CAGAAGAGGI TGGITCCTGC CAAOTOOTAA GTGCAGTOGG GAGCCGIGT ITOGACTOT TCTGGAGCTC GOACAIGIOG AGCGACAGGA AOTCGAACAI TCCITTGTA GCTOOACITTT CCTCTGGCIT CGGAAATGCT TACGGAAAGC TGAGACGGAA OCTACGAAAA GCGITGITAG GGAACTAGAG OOATAGACG AAGTTAACAG ACTATGCCAG ATGCCTTTAT GGCTGAAACC GAAOOAG CGITCAACTO AAAAGAGICA TAAIOAAGGG AAAOOATAIT ITCITGGAAO TTCTAACT CTCGGITOCT CGCIOTAA.AA TOGCICTCA CAGTOTITCO ACAGCTGAIT OTITAGAGGA AAAAAATGAG TAAAAATAIT

ITCCGCTAIT

OGATCAACTC

AATOTCAAO

OTGCAAGI'TC

CACGOOTG

CGCTGCGO

AAAGAAA1Tr

ATGGTITAAG

AACITGAGTG

GGTOOCAGIT

GCGTGTGGTG

GOCCTGCTACG

AGTCTCGCTG

OITGGTOCCA

TTCAAAAGAA

CACAICTGAG

CGOOAAAOA

AAGGATGOAC

TACGTGTGAA

CGAGATTAO

GCAGCTGCCA

TCAGAAACG

GGACAATGGA

IGAAGATOAO

GCTGAATGGC

GCTGGGACTO

CACCAITTCT

AAGCCITGAA

GTGCATCTGG

GOAGAATTCA CGTACAAGTC GTCITTGG AOACAOATAA GTGTGGTCOG OGTGTGGCC ITCTOGT

GCAACACGGA

OITGTTTr

CAAAGGTGAA

TTGOCAGA

ACACGOTOG

ATAACITAAA

GCTACGAAT

TGITAAAGA

TGAGCAGITC AATAOATGAA TGGTAGTGTC AOGATCAAOA GAGACGAAOA GTCTOAAATC GAAACACAAT AITTGTOGG TGTGATAAGA ATGAATAATA AAAATGACAG ATOITOAATG GCTGTGTGCG AGGOITACTA OTTCTTAAOO ATTOTOATAT

AOTCCGCAO

AAGTGITGC

ICGAAITGG

ITTCTTTCIT

ATIATCCAOA

CCCAGAGGCA

TGCAGAATIT

TITACITGC

AATOCATOGA GGGTOITAA AATCAGTTTC ATCGIATOO

TOTGAAAT

GATTCGTGC

AITGAATATA ITATAATCIT CGATAGITCT IGAITGAATA CAAGTGTGGT AOGGACTTAA AAAAGITGTA 161 AATGCTGTCA ACTATGATAT GGTAAAAGTT ACT-rATTCTA GATTACCCCC TCATrGTTTA 17AACAAATT ATGTrACATC TGT-rTTAAAT TTAT117CAAA AAGGGAAACT ATTGTCCCCT AGCAAGGCAT GATGTTAACC AGAATAAAGT TCTGAGTGTT YITTACTACAG TTGTTFTTTTG AAAACATGGT AGAAUTGGAG GAATGGAAGG TTTGTATA11T GTCAGATATT TTTITCAGAAA TATGTGGTTT CCACGATGAA GAGGCCAAAC GTT-rTGAACT AATAAAAGCA TAAATGCAAA CACACAAAGG TATAATrTTA TGTTGGAAAA GAATACAGAA AGATGGATGT GCTTTGCATT CCTACAAAGA TGT-FTGTCAG TAAACATAAT TCTTGTATAT TATGGAAGAT YI'TAAATTCA CAATAGAAAC TCACCATGTA CTGGTAGATT TTTAACGAAT GAAGATGTCT AATAGTTATT CCCTATTTGT TTTCTTCTGT GCTCTGGAAG AGAGGAATGC CTGTGTGAGC AAGCATTTAT GTTTATTTAT AAGCAGATTT AAGGAATCTC CAGTTTTCAG YfGATCACTG GCAATGAAAA ATTCTCAGTC AGTAA-f7GCC TAGCCTTGAG GAGTGTGAGA ATCAAAACTC TCCTACACTT CCATTAACTT AGCATGTGTT( GTTT1CAGAGA AGTTCTGGCT GAACACTGGC AACGACAAAG CCAACAGTCA AAACAGAGAT TCAGAACAGC AGAGGTTCTT 'rrAAAGGGGC AGAAAAACTC TGGGAAATAA GAGAGAACAA CAGGCTATGT ATGGAATACA GTGTTATTTT CT-rTGAAATT GTTTAAGTGT TGTAAATATr GCATTAGAAA TTAGCTGTGT GAAATACCAG TGTGGTTTGT GTTTGAGTTT TATTGAGAAT AACTTAAAAT ATTYITATAAT 1TTTAAAGTA TATATTTATT TAAGCTTATG TCAGACCTAT ACTATAAAGG TTGACAATAA ATGTGCY17AT GTTT GATCAAAAfl T17ACCTATT ATGCATrGA AGTATATAAA TOCACACACA GACACAGCAA TGATGGTGAA CAGTCTTCAT ACAATTATAT CATAAAATGC TGAGTTAAAG AAATCAGACC AAAGAACATA TACTGAAAGA Y-FCTCTCTAT CAAAAATAGG TGGACCAATT CATGGTGGTG TTAGAAATCA GAAGAGAGGC TACCTJTTGTG AGTTTAATGC CCAGAAGCGG TAAATAAGGA ATCCTCTGGG GAGTGGTAAT GATCTGGATG GATGTGT-rGG TTGTAAAAAT GCATTTTT ATATCTAGCT TTTTCCATGT GTATATrATA GTTCAGTTAA TAATTTCTCA TGTCACTGTA GAGTAGCTCA GTTAGCCCCA GCAAGCCTCT TGTTTTACCT TAAGCCATCA GTCA1TTACA AGTAGGAAAA TTCACAGGGA AAGTTAGAGT GAATGAAGGT TTACTGGGTA AGAGTCTCTC CATTCCAA AGCCCGTTTA TTI7CTTGATT AGAAGTCTCA GCATTGTGTC 1TVFTCATGT ATCTrACAAG AAGACAGCAT GTGCTI7CTAA ATTGTATCTA CCAGCACTTG GTAAACAGAA AAGAACCACA T17ITCTTGT AGGAGAAATT 'FfCCTACCAG GCACCAATAA GTGGGACCAA TAGGTGGGAT TAAAGATAGA GTAGAAAGTA GCCAGGGGGC AATAGTCTGA AAATAAGTAA ATTGGTGCTA TAGAATGGAA GTTACAGGCT TTCCCACAAG ATCTGCTCCT TGAGCCCCTA GAGACTTTTC TGTCTGTTAC TGTTJTCTTCA GCAGAGCCAG CCCTGAGAAG TGCAGACCAA AGCCAGGGAA GGCTCTGCAA AGATGTACAA.

CCTTAATAAC CTCTGACTGC TGCGCATAAT ACAT'TCACT CAAAAGAGGG GTTAAACAAT

AGTAAAAACT

AAACTTCCAT

TGAATGTCTT

ATGTGATATG

AAAGAGTCAT

ATGTTAGGGT

AACAATTCCA

AAAGCTGCTC

3AAAAAAAAA

GTGATAAGGA

CTACTGTGAT

TATGTAAACT

TTTAAATTAT

TTGACATAAC

TATATAAATA

GGATGAATCT

ATACAAAGTT

3GGAGGGGAC

CTGGCTACAG

CTTCAAAGAA

GGCTTAATCT

ATAAAATCCA

CCAGTfC'FfA

CACCTGATAC

TGGTGCCTAT

TTTAAAACTF

TCTTTCTTT

TTICCTCATCT

ATGGAAGTCA

GGAACAGAAT

ACAGAGGCCA GAAATAATGC TGAACACTGA TGGAGAAAGG ACTCCCTATT CCATAATGGT GGGCCCCTTC cU-ACATCAT ATACAAAAAA ACTATAAAAA CCCTGGAAGA TAGCCTGGGA CAAGACACCA AAAGCAATAG CAACAAAAAC AACAGATAGT TTATCTGTAC AACAAAATAA TTrTGCAAACT ATGCATCTGA CAAAGGTCTA AAAAAAATGA CCTCA'rrAAA AAGTGGGCAA ATCCAACAAC CATATGAAAA GATGTTTAAC AGATACCATC TAATACCAGT AGGAATGACT TGTGGAGAAA AGGGAATGTT TATGCACTGC TGTGGTGATT CCTCAAAGAA TGTAAAACCG CCAAAAGGAA TAGAAATTGT Y7TACCGTAA ATAGCAAAGA CATGGAATCG TCTAAATGCC ATATACATCA CAGAATAGTA TGCAGCCATA TGTAGT[GGA GGCCATrATC CTAAGCAAAT CAACCATCTG ATCM~GACA AAATCCACAA GCTGGGATAA CTGTCTAGCT ATATACAGAA TAACTCAAGA TGGAGTAAAG ACTTAAATCT AATACCATTC TGGACATAGG ACCTGGCAAA CAAATTGACT AATGAAACTA ATGAAACTCT

AAACAAGCAA

GATTGAACCT

AAAACCAAAC

GACTrCATGA

TTAGTTGTAC

ACTATCAACA

ATATCCAGAA

AGGACATGAA

ATCACTAATC

ACTATTAAAA

TAGTGGGAAT

AACTGCC1TTT

GAGTAAACAA

TCTATAAGGA

CAGATGC'Tf

ATTAGAGGAA

AGTCAGACAA

GTAAACTAGT

CAATCCAGCA

CCTACAGAAT GGAAAAATTT ATTTAAACAA ATTTACAAGC TCAAAATAAG ACAY[CACAC TACAAATCAA AAGCATAATA TAACAGATGC TGGTGAAGGT TCAGCCA117G TGGAAGAGAG ATCCCATTAT TGGATATACA TCAYI7ACAGC ACTA1TUACG AGGCGCATGC ATGCATATGT

CATCAGTGGT

AAAATGAACA

TAATGCAGGA

AGACTAGCTA AAAAAAAAAA AATGTGGTAC AGATCATCAT GTCCTTTGCA GCAACATGGA ACAGAAAGCC AAATACCACA TGTTCTCATT TATAAGTGAC AGCTAAATAT TGAGTACACA TGGACACAAA GAAGGGAACA ATAGACATGG GACCTACTTG AGAATAGAGG GTGGGAGGAG GGTGAGGATC AAAAAGTACC CATAGGACAC TGTGCT-rATT ACCTGGGTGA TGAAATAATT TGCACACCAA TGAACCTAAA AGTTAATGGT AAAATAAAAT ATTTACCTCA GATGTTrAAT CTCACAATGA GCCTTGGAGA GATTAAATGC GTTCTGAATG GTTGTAGG TCTGGTGTF GTCTTGTTTG YTMACTCAA AAATT-rGAGT GAAAT11AT GGAGTAGTTC CTGTAATr TTTTCCTCAT AAATAAAAAC CTTGTTTTTA TGATAAAATC AATGTTAT-rA CCTGAAATrC TACCATCCAG TATATATCAT CCTAAACTTC c~rTGAATGA AAATAAATAC AGTCATGAGA TAATGATTrA ACCCCTGTGA CACACAATTT ACCTATATAG AAAACCTGTG CATGTACCCC GGGGGGGTGG GGTTAAGCTA CTTTGTGGTA TAAATCTGAG CATTCATATT TTAGAGTAAT TAACATTTAT TCTTTAATCT CATAACAACC ATGGGGCATG CCATTTGACT CTTTGTTTI TCCACATTAT GTTrTAAGTGA AGCAAATATT ACAGTATGGA TCTTCTGAAG TCAATTITUA TGTAGTTCCA TTGGACATCA GCTTTITCTT TATCAAGTGG GGACATTTT7 TFFMAAAAT TTrGATT7AA AGATAATAGT GC'17AAAGAT 1TTGTATAAA TGTATATAAA

TAAGCAAAGA

GTCCATTGTA

AGAAACTGGA

AGCATGGCCT

TAT1TAAATA

CCAAATAACT

CTGCAAAGGT

ITCCTCAGAC

TCCAAATGAA

AA-ATCATTAA

TTGATATATA

GTT'TrAATA

GCCAAGTACC

TGTACATATG

AGCATCAGGA

GCCATGAAGA

TTCAAGATAT

CTTATTCAAT

AAGTCT~rATG

CCGCTGAAAG

AACCGTGTAT

AAATAAATT-F

GACACACACA

AAAACTAGGA

1TATAACAT

GTGCATGAAC

TAGGTAAATT

TrACACACAT

TGGAAATTGA

TTTAAACTCA

ACAGGTCCUf GCTGTrAAAT

GCTTAGTTGA

GAAAGATTCA

ATAATITA

TCA'F[TTATA

TCAGATATTA

CATATATACA

GAT-rAATGCC

TTATCACAGC

TCTGGAGCTA

GCTCTTGTTC

AATGTGTATG CTITAACATC TTGCCT-rrAC CATGGTCATT G~rAGTAAGC TAATAGCTAA GCCTCCCTGG ATTITAATCC CAGATCTGTC ACTGACCAGC TGAGCAATAC 162 CTTAGT17CT TCATCTGTAA AATAGAGATA AAAATAATAT CCACCTCATA GGATTGGTGT TGAGCATACG TATGTAGGCC ACYI'AACAAC AATGCCTTCA CATACTGAAC ACAAATATAC CUTATTGGGC TCATGTT1TTT CCTACCACTA AGCCGCATGC ATGCAAGGAC CATGTTGGTT TTGCATCCCC AACCTGGTAT ACAGTGTGCA 11TCAATAGTT GTTGACTATT ATTACTAGTG AATATCTGTT AAATGAGTGA AGAAATACCC ATTTACTGCA AGTGTGTCTA ATATTGATGG GAAACTCAAA CTCTGGAGTC AAACAGGT[ TAAAACCTTA TTCCCTCATC CTCAG17ATT I-TTGGCAGG TGTGTGTGTG GGACAACTTA TTGAACTTT-r CTGAATTTCC AGCTJ7CGCAT GAGATAGTGA TTCATTCTTG CAATGTATGG A'FrTGAGACA ATTGTGTAAG TTTATCAATA ATTTGTAT AAGTA11TACA TATAATATCC AGGCCACTGC TTTGCATAAC CCAAAAGGGG GCAGAATACA ACATAAATGG TGTCCCTGGA GCAGTGCAGT ATAGGAACCC TGAGGGGACC U-TATAGTTC ATAGATTACA AATTATCCCT TTATCAGAGT CTCTCAAGGT TGGATGTATT

GAGCATTAAA

GAGCTGTTGT

TTGTTrCCACA

GCATTTAACA

CATAATGGGG

GACGTTITT

ATATAAAATA

AATAGTAGCT

CACCATTCAT

TACAGTATAC

TGAGGTCCAT

AAGAGCAATT TAGGATTAAC AGTAGCTGCA GAAACCATCT GCAGTGATAT TCTCATTTTA AATCCGCGGG AAAGAAGACA GCTATAAACT TGGGACCTGG GTfTAAGCAT TTTAAATGCC AAG17CACCA U-TTCTAAAA CACAACAAAT ACCCAGTGAG AGAGGGAGAA GGGAAGTAAA TGCCTCTGAA TAAGCAAGTT AATGTCAGTA GTTGTACTGT ATGCATAT[G ATGAACAATA GAGGAACCAA TGTCCAATCA GATGAGCAGG ATAT~rGGCA ATAACAAGTr GCCTTITGAGG AAAAATGATT TTCTTGGCAA GTTCTTTATC AGCATTACAA AGCTAAAAGC TACGCTTATC ATCACTTATA CTAGCATACC CTGTTGTGCA AATGCTGTCT GTGTTTrGCAT CTGCTATTGT TGATGCCTGG TGCATGAATC AGGACTCCAG CCCACAAGTT TTCCCAGAAC TTTC'FrATGG CCATCATCTT TAAGTGTCTG GTGAACAGTC ATAGTTTGGT ACACAAAAGG GTCAACCTGG GGGATGGCTA GGGTYFGACT CAGTCGTTAC AUrTCAATAG AGCAGGAAGG GGAAATGGTG GCCTGTAACC TCAGGGAAUT TrGCCAGTTG GTCCACCCCA CTCTCTCTCT CCTGCTCTGA GGAAGTGGCA CAGCCTAGAA CAGGACCACA GGTGAGAGAA ATGCAAACCC TAACCAGAGA AGCAGACTCT 11TGCCAGTAG TAATAGYI'CA GGACCACCAC CAGCTTFTAT TAAAATTTTT AATAACACTC AAGTATTGGC AGAAAGAAAT AATCTTGGGT TAACTATAAC TAGAATATTG ACTCYI'CCTC TGTGGAAGAA TCAGCCAATC ACATTTGT ACATCAGTTC CCCTGAAGAA GAAAAATACA CTGATGTTGC AGCAAGACAA AYITAAGCTA GATGTAAATA ACfTCCTTTA GCCTGTAATG CTAGGCTAAT TACATATTGG AACTATTT-rT TCAGGGAAGA ATTGTGTAGG GTTTCAGGGA AGAATTCTGA AGAAAATATA GAGCTGAAAT GATCTTGCAG CTCACTGAAA CTGCAGGGTT TAGATCCACA CTGATACTCG TrCTATfATC ACTGTAATGA AGGCTGATGG AATAAGTAAA AATGTTfTGT ATTAGTATGT TTTTACAC317 ATTTrGCAAGG CATAAATAGG TTAGGTITTG ATCT-TAATTr AATTCTAACA TGTATTGTGC ACAAGCTGTG AGCAGTTTC AGGAGTTAGG TATCTGGCCA TGACTGATTT TTCAGGAGTT AATCATCTGG TAGAAGGGTC ATACACAATA GGAAGATGTG TGTGACAGGT TGTGATCATT ACTATAATCA CACAGAGAGC TGTAGAATTT TAGGCTGGCA GGGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCCA AGGCAGGCGG ATCAAGAGGT CAGGAGATGG AGACCATCCT GGCTAACACG GTGAAACCCC GTCTGTACTA AAAATACAAA AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GCCTGTAGTC CCAGCTACTT GGGAGGCTGA GGCAGGAGAA GAGCTJTGCAG TGAGCCGAGA TCGCATCACT GCAATCCAAC CTGGGCGACA AAAAAAAAAA AAAAAAAGTC ATGTTAGATC CAGAGGGGTA

GTCAACTCAG

CAGCATCATT1

TTGCAATGTT

TTTCCATT-rT

TGTYFAATATG

AAACTGAGCA

TJTGTTCACAT

TTAAGGATAT

TTTGGCTA-T

TFACCTACTC

GATGAGTGTC

CTUCTGAAGT

TAAGTTGGGT

GTTATTCTTT

AAAGTTTCTT

CACAGCATAT

TCTCACATAC

YITAAATTATT

GTTAACCTGT

TTGTTCATG

AGTGTAATCC

TAATCCTCAC

TCAACTCTGC

GAATTACTCC

TGGAAGGTAC

AAAAATCGTG

GTGATYITAAT

TGAGGCTATA

ATATTTGTGA

TTTAGACTTA

flGAGTATTA

TAGAGATATT

ATAGATGTTC

TTATTATM

GTTTAATTT

TGCTGCACCC

TTTGGTTTTT

GGCTrTGAAA

TTATCATT

AAGCATATTG

ATGATTCTAC

TCCCCCACAG

TGATTATAGA

TCCTITTAG

AATTCCTYITT

GGTTAGAAAT

T[TTTTAYT

ATGGGA117GG TGAAATATTfr

CCCAATATAT

CMrATGTAC

ATCTATMT

CTTTTCCA

TAGCTTGCTT

CAAATTGT-rG

AAAAACTAAC

TATATGTACA

TTGTGGTGAG

GGATTAAG

ATCATTGAAA

GAGATGCCAG

GACACAGCTG

TAAGGGAAAT

TGCAATATTG

T-rTCTAATGT

GCTTCTATAT

ACTATTUTTC

GGCAAACAAT

TTTAATTAAG

TCCAGA'TMr

TUATCTTCT[

CTTCCTTATG

TGCTTTT'TTA

ATAYI1TCTAT

TTTTTAAATT

TTGTGGAATG

AGCTATGTGA

TAATTTACCT

1TTATTGACA

GCAACTGGGG

TGATGCA1TTT

CAAACGATTC

CCCCTCTTCT

AGGTGGTTAT

AAATUCCACT

TTGGTTGCTA

CTTCT-TGCCG

CCTTGGCAAG

TTATTCTTAA

GTCTATTTAT

TGATCTTCTC

GTTTATTCTT

GGATAAGCAT

TGTCTAATI-F

GACAAATAAA

GCTAAATTTA

C=hIGAACT

TTTTATTATT

T-rrGCTTCAT

TGGCGTGAAC

GAGGGAGACT

CTGGGCTGTC

TCATGGCCAA

CCCATTAAAT

GGCTTGCTGA

ATGGTTTCTC

CATATTOGCAG

TACAGTATTA

ATTTTTATCT

TAATTTrTTG

TGTTTTCTTA

ACCACTITTC

TTATTCCTTG

TCAATTT11TC

TAAAACTACA

CTATTCAATT

AAT7GTGTAT GCTrATTAAT

TATGAGTTAT

AACTTATAAC

AGTCTATTAT

CACATATGTC

CCGGGAGGTG

CAGTCTCAAA

AGTCAACTCA

CATTGTCAGT

ATGATGTTTC

AAGTTTUTTC

TTCTCTAATC

AAATAAACCT

TGTTTAAGAT

GGTYTfAAA

GGGAAT[GT

ATTAAAAAAA

TITI'TTCCTC

TTTCTATTAA

TCTAACTTCT

AATTTTCCTr

AGAATACTTT

ATI7TATTGTG

GTATGCAT'TA

TTAAATATT[

AAGTAGAACA

ATGGTCTACT

TATGAAATCA TrACATCTGT AGTAGAATTJG GCTAATAGTT GAGTAAAGTA AGAGAAAAAG AGAAATAC TGAATATATT G'rrCTAGGTG CTATTATATG TrGTCATGTT CACAATI7GTA TGAGGCAGCC ATAATTAATr CCACTTrTACA CATGAGGAGC CTGAGGGTTA AAAAAAAAGC TAGCTCTACT ATTJ7GTAAAG AATGAAGCAA AGATACAAAT GAAGGCCCAC ACTAGATATr TAAGCATT= AATTCAAGCT TTAAAACTGC TAAATAAAAT GTGCTCCAAT ACAGACATAC CTTCCTAATG AGCTGGGGTT CGAATTTAGA AATCTTTGAT GCTTCAGAGT ATGTGGAGOC ACATAGTGAG TTGGTCCCCA GCCTTCAGTC CACCCACCTF CTCTTTACTA CACATACATG TATGAACACC CCAGCCTCCA AGTCCAAACC CTAAACAAAA TGGGACACCC ACAGAGACAC AGCCCATCCT CAGGAAAACC TGGAAAAGTC CATACAAGTT CTGGAAGCAA GT17CAGTAG TGTGGTCTAT AAGGGAGGCC TCAGAAGACA GGT-rTTCTrA AYJ7CTGTGAA AGTAGAAAGG GTGCTGGAGG AGGGTCAGAG TGAGGACTTC TAAAGCATGG GTCCTGAGTA TI7GCCCAAGT CTAAGAAGGG TACTAGAATA GCACACTACT ACTAGATACT AGAACCCAGA 163

ATATCCTATA

T'rCTATATTG

CCACACTGAA

AATCACCTT-F

T-FGTGCATAC

GCT7GGGACG

CTTCTCCCAC

GGGGCCACTC

TACAAGCACA

GGTCTTCTGA

TTATTATTrG

GGGATGTACC

AGTTACAGAG

CCTAAGTCAT

ATTACAGTCC

ACATTCTACT

GCTTTAACTT

TTATCGGGTA

AAAAGTTTGG

TAATGCTCCA

CTCCAAATCC

CTGGTACATT

CTCAGATTGC

cT-TFCCTAT

TCTCTTATAT

AGATCTTrTGA

TGAATACTTT

CCTTCACAAT

CTGACTGGTC

CCATITGTGAT

AGTTGAAAGC

CTAACTrFCAA

TAATTTTGCC

AGCTTGCACA

CCC31TCCAGA

CYJTGCAGTCG

CTCU-rTTGC

AGGGGTCAGT

TYFTTGTTGTG

ATCTATTCTA

TCGTTATCTA

ATATCTCTGA

TATGAGGAAT

GCCGCAAACC

TYFTTCTTCTA

TATCCACTTI'

GGTCTGGGTT

AAATCCATAC

GCTTCTCACA

GCTCACGGGA

ATTGTTTGAG

GATAGCTTC

ACAAACTTTA

CAGGGATGCA

TGAGTAGCTA

CT-FGTTGTAT

TTGTTGGAGT

CT-FACTGTTA

CAAGCTTCAA

CCAGATGGCC

CATTCCACCA

GGCTCAGAAG

CTGTAAT~

TTTCAGACTC

TCTCTTCACA

CCCCTGTCAT

CCAAGGAACA

CTATCCCTCA

TrccrrrcTrr

ATGGACTFFGG

CAT'FfCAGAG

TGCCTGGGTG

ACCCC117CTC CTCCATTrcCT

CTAAAACCTA

AATAGCCTGA

AATTAATAAT

CCAGTCACTG

CTCATTGTCA

AATAATAACT ATrACCATTA TTATACCAGT TrTCTAAA1rC TTTFACATGTA T-TATACAACT CCATTTTACC GATGAGAAAA CTGGCATAAA

AGCTGTCAT[F

GCCATATAAC

ACGTTTAAGT

TATTTAGTGC

TGCCATATGA

AACTTGTCCA

CTTFAGTGAAG CCACAATGTT AGAGTCTTTA AGAATCAGAG AAGAGAAGAT GGCCCTGAGT GAAGATAAAA GATAYITAAA TTCTCAGAAC AAGAAATCCT GTAAAATATA ACTTTTCTTC AAACCATTGC TATGGGTATA GAAGTAATTA GCACAATTGT ACATGAAACT GATTATACAG GAGACAGGGT CGGCCAGTCT TTTCT1TT7AA GGGGTCAGAA TCCCAGTCTC CGCTATTGGT rAAGAATTAA ACAGCTAAGT AAAATGGAAC ATTTGCATAA GCTCAATTTG CTCTCAAACT TCAAAGGGAT GGGAAGGACA

CTAGAAGGAA

TACTTGTAGC

GATATCGCTG

TTTTGGTTTf

TGTAATAT

TACTTTCTAA

GCAAGTCTGT

TCAAAGGCGA

GCGTTAGGGT

CTGATTCAAA

CYrTGTGAAT

TCATGCAGAG

TCTTAGATGT TATCTAGTCA GCCTCCTCCC TA1TTTGCA TGTGAATTGC AAGTGAATAT

GATATAGGAA

AATCTATATG

TTFTAACTTTA

AGGGATAGTA

GCATCATCAA

GCCCAGTGGA

CTTGGTCAAA

TCTACATT

CCACAGGCAA

GAAATATAAC

CAGTGGITTTT

CACATCTGTA

ATGAGTGT'TC

ATTTCTCTAG

CTATACATTC

GAGGCATTTT

ACTGCATTTC

TAAAAGCCTT

iTTTGCCACA

AAAGGAGGGA

AAATCTCTAG

TFTCTCAA

CTCATAATAG

AATAYITCATT

TGCCTGTTTA

TGGAGACTTC

TGAAACTAAA

AGATGTGGGG

TCCTJ7GACTC

CTTTCCTACA

GTTACACCTC

GGTTTACACT

TCCCCTGCT[

CCTGTTCCAC

CACTCTATCT

TACC'ITTGTC

TCTGAATTCT

CTTAGCATAG

TGCTGGATCC

TACATTCA

TAAACATGCC

TCCGAGGATG

AATTGAGAAC

AGTAAfTT

TTAAACAGAC

CTCCCAGCCA

TGAACCTTCC

CCGT-[TATCT

TCTTGCTCAA

CT1TT-[CATC

TJTAGATACTA

GU'GCCCT

CCATAGCACA

CCAGGGATAG

GCAAATGTTT

TGTGTCCTTT

CTGAAATCAA

TGGCTGCCTA

TATTCCCTTTF

ATrCAGTAAC GTCATAT1TfA

ACCCCCCCCC

TGGCCCCACC

CCACTCCTAA

GTTTTCCCAG

CCCAGGTCTC

GACTCTCCTC

GCCAAGTGAT

CACAGCCTTA

GAACTCTGCC

AATTGGTTAA

GTCATTGAAC

GAGACATAGC

CTTfTGGACT

TCTCTATGGC

TCTATAGACA

kAAATGAGGA

CATCTCTCTA

TTCTCAGAGA

ATATTTTGTC

CC1TCACCYT

ACAGAGGTTA

GCTI7CTGCCA

ACTTTCATITA

TAAG'TrCT G3TAGGGTCAC

GCCTACTAAG

ATTAGAGATA

*GCCAGAACTG TTGTYJ7TATA TTTTCCU7TC TCCCTGACCC CAACTAGTCA GAGACCAAAG CTCATCATCA CGCCTGAATA ATTACATTCA ACCCTCTGAC ACCTTAATCT TCCCAGAATA AAACTAGAGT ACAAACTTTA TAAGCTfAG TGCCAAGGCA GTATAACCTG TCCAACATCT CTGGTTTCTA ATrAAACCTG ATCTAGGATC CTCTTCCTCC TCTGAGCCGC AGCATCTCTG GCYJTGCAGYIT CAGGGTGTTT ACCTTCCCTC CU'ATGTGTC CATAGCCCCT GGTAGTATGT TTGAAGACAA CTGTCCCATG CCTTAAGCCT AACTA'f7TTG ATCTATTIFTC TTCCTGACAT TTATTCTCTC AAAATTGCTT TCAAGAGTGA ACCCACTTCA GCAAGAGTGT TfGAAACCAA ATTAGACACA CAGCTCTTTT AAACTACCTf CTGTCTAGCT ATATGAACTT AGACAAACTA CAATACCATC TATGGCCGGG GATTAAATGC AAATCCAGAT AAAATGAATT AAAAATACTG GCTTAATTY[ CATGCTCACC ATAGCACCGA CCAAT"TTTGC CTTrTATGGC TATTTCITTCA AAACTCCTCC TflCAAAGCAA CCTAAATACA GTGTGATGCA GAGGAGGAGT CATGCTGTT7 CCCCTACCCC TCCCGCCACA GAGCTCTTCA CCTTCTCTCT TTTTrrrrrT CTITCTCATGT TAACACAGAG TGCCTITAATT ACATATTACT ACCTGCTATA TTAGAGGCTT ATCAAAAAAA ATAACTGGAT GCCAAGATAA GTTfAACCTA GGTACTTAT[ CTGTCACCCA GACTGCAGTG GCTTCAGT[ CT-rAAAATTT GTAAACCAGA TGTCAGGTAC CTCTCTAAGA GTTCTCAAAA AATATTJ7TGT TTCTACCAAA CCCAAACTAA AGAAGCAGCC TGTATTCCTA GTGGGATGTT TAGTCCCCAG AGGCCAGGCT TTCTAGT-rC TTCTCTCTCT GCAGAGAAAA TrAACTCCTC TTCCTGCCAA CACTACGTCT TCCTAAAAAG GGA'FrTGGAT TTATTATTAT TATTAY7A1T ATAATAGCTC ACTGCAGCCT GGACTACAGG CATATGCTAC TGCCCAGGCT CGTCTCAAAC TACAGGCATG AGCCACAGCA CAAAGTCCTG AGTTCATGCA ATCCYTCTGC TTrCAGCTCCC TCTGCCCAGC TACTTTTAAA AAAATAATTA GGGATGGGGT TfTCTGGTrC AAGCAATCCT CCTGCCTTTr ACCTCCCTAA CTCAACCAAG ATTTAAAAAC TT117AAAAGA AATCACATTA AGTGTTAAAA CAATITGGTAT TGAAAACACC ACTACCAGAT TTATITGTCAG ACCTCTGAGC CCAAGCCTGC AGGTATACAC AAAAGAACTG AAAATGGCCG GTTCCTGCCT TAACTGATGA TCATCATTAT GGTTACTACC

ACCAAGATGT

TGAAGCAAGT

ITGTGATG

CTCCCCGACT

CCACTACCCA

AACCTGC-CTG

CAGACCATGT

CAAGTAAATA

GAAGAATCAC

TTCCTGCCCC

GAGTACCTTG

CCCAAATCCT

CACCTAGGTG

ACCTrGACTG

TGACCCCCAC

ATAAAACAGC

ATTCAAAAGC

AGGGATTAAC

CCCTGCCCAC

CTCACCCCTA

TTI'ATTGCTC

GACATfGGT GCCGTAACTC AGATCGGGGA CCTGCTCTfrT GCTCCATGAG AAAGATCCAC CTATGACCTC TCTCACCAAT TrTAAAT[GG GTAAGTGGCC TC1TTTTACT ACATCTTTCT CCTITCAATC TTGGCACCAC TCTGGTAG AGACAGAGGA AACGTGTTCT AAAGACAGTC TTCCCTTGAT GTTTAATCAC CTGTCTGATC ACTGCAGGGA CGCCTGCCTG GCAAGCACCA CCTCTCCTGG GGGGCAAGCA TCCATGTCTC CACCCTCTCT TCTCTGGGCT CCCTIJCTC CCTAGCCTG TGT-rCTCAAG AATGCCTTAC TfCTTrCTGC AATACCGCT1' AAACGGCACT 'rrCAATrCT CCATCCCACA 164

GCTTCAATCT

ATCTGTGAAC

TGCAGGGATG

GATCCTTCAC

CCACCTCTCC

TGCCTCCITC

AACTITAAAAC

GACCCCAATA

AGATCTAAAT

C'rrGTGAAAT TCCTTCCCCT AAGTGAAAAA CCCCCTTTGA TCTCCCTTCG CTGACTCTCT ACACAAAGCC TGTTTGGTGG ACCTCCCTrG GGAGATCAGT TGGTCCTCAG ACCAACCAGC CTCTTCTCCA GCCTCTCTCA CTCCC'ITCCC TTfAATTTrCAG CCAAAACTCC AGCACTGGTC CCTGCCTGAT TATTCACCCA CTTAGTGGCA AGTACCAC'Ff TGGGGGGCAA GTACCCCCCA ACTATGGGCC ACCTTCCACC CTCTTCAACT CACGTCTGAC CAAACTCAAC AATGGTTrCCA AATFC~rGTC GTAAAATGGA

CAAATGGTCT

ATGCAACTCA

GAGTCTTrCC

AGGTCGCTCC

TFCTATCACC

GCCCAACAAT

TATCCAACCT

ATGGCTCATfr

TTCTCAATAT

CCTCAAACCC

AGTAGCAACA

GAGGTGCCTG ACATCTGGGC ATTCTTTTAC ACGTCGGTCC

TCCCAAATCC

AATCTrrCCTT

CCGCCAGGCT

TCCCCTCCTC

TTCCTCT-rAA

CTCCCATCTC

TGGCAGCAAC

TCCYFrCUTC

TTCTACTGAC

GAATCAGGCT

ACACCTGGTC

AGAGGTGGCT

AGTTAGTATT

TCCTAGACAT

CCTCCTGCCT

CCATCTGACC

CCAATTCT-rC

CAGCTTACAG

GGAGCTAAAG

TAGGCTTTTT

TTTACAGCCT

GTCCCCTCAG

TCTCCCCTCT

CTCAGCGTCC

TTTCATTCTG

GCATAGTCA.4

TTCATCAAAT

TGGACCCAGA

GCATT'rrATT ACCCAATCCA CTCCCAACAT TAGAAAAAGC

CACAACAGGA

TATTTCTGAG

ACACAAGAAC TTCAAAATGC TGCTTCAAGT GCCAGAAATC GTTCCATCTG TGTGGGACCC TGGAACTCTG GCCCAAGGCT TGCTGCCTGA TCGCCTCAGA AAGTCCGTCC CCTFCUTAAT CCCUTGTCTT CATAAATGTTr GTGCCGATTfr AAACAACAFU GGCTGAGACA TIT17AACCAA CCCTTICTTCC CAACCCAAAA GGTATGGGAC ACCTCTACTC CACCC'FFACC TGGGTCAACG CTTGCCTGT17 ACAACATGTC AAAACTGGAC ATGCCTTACA GCCATGGTGC CAAACCCATA TCTGTTCTGG ATCTCAAAAC YrCACTTGGA CTGACCCTGA TGGACAGCCC CCATTACCTC CATGAAAACA CACGTGCTCT GACTTTACTC ACATGCCCCA AGGTAGATGC CTTrCCCACA TCCTfOGGTTT GGCCTTCCCA GCAGTTTCTC AGGCTCTTGG TAGAACTGAT TAATGGTCTT AGTACTTTTA CCACTTGCCA AAGATJTCTGT ATGGACGCTC TGCCCCAAAA ACTTGTCATC GTAAATGCCC TGCCCTTT-T TGGTITACC TCAAACCGCC ACTCCAATAC TTTCACCCTA CTTATGCCAC TCTCTACCTC ATTTCTAATC CTTCTTTAAC TCAATTTACT CACTGCTAAA CAATCTGGCC TGGTATATGA AGTAATTATG CTGAACCCCC ATACCTGT-rT TTCTCCTTCT GTATCCAGGC CATCACCAAT T-rATGCCCAA ITrTCTGCCTCC AGCCTGATGC CACACCCTGG ATTACAGACA TI7GTATGGAA CGCAGCCCCT AGTCATGTAC GACCCCCTTA GAGTITGTAAG ATGAGTCTTG CCAATGCTCC CTGTGTCTTG TCCTGCTACA CAGCTTAATC TCTCCCACTC CGCCCGYI7AT CTCTCCACAC

CTTAATTAAC

TTGCAAT-CC

CTAAGCCACA

TGGCCACTGG

CACTGGAAAT

CTCTGACTGA

AGCCTCCTGG

CAATGCAGAG

GTGGGTATTG

CT1TATACA

ATTATTTGCT

GTGGCAACTC

CCTCCCTGGC

CCAGTATCCC

CYTITAAAGC

GGTTAGTTCA

TACTCTCCTA

ATGCTCTT

CACCCATCAG

AGTCAACCCA

CCCTGCTGAT

AATCAGGACA

GGGCCTAAGA

TTGCCTCCAC

GTGGTCAAGC

GCCAAGGAAT

CGGACTGTCC

CTCCTTFCCCA

ACCATCACAG

GCTACCCACT

ATGGCCAGGC

CTTCTTrTTA

TCCCTGACTA

CTTTGCCACT

AACAAATCAC

ATCCCACAAC

CTGTAAACTC

GGATCTGTGC

TCCTCAATAC

TACTATTCAT

CCTCAGCAAC

AATTTCTTCT

CATGTCCAGC

CTAAAGTACC

TGTGAGAGAA

ATTCCTACAG

GCCCTCAGCC

AACTTGCCCA

GATCTTCTTG

ATGCTTT7GG

CCACATTACC

TTCTAAACCC

GTTATCCCCA

TTCCTGGACT

TCCTCTCATA

ACCCTCATTA

AGGCTT7AAA

TCCTTACAAT

CTTATCAACC

CTCCCTCCAA

T-TGCACCCTT

TTACCTGGGC

TCATCCA1TA

TAATCTCCCC

TCTrGGTCTG CTTGCCTTCA AAGCGTACAA

CTCCCTAGTC

TCCCAACCCC

TCCCCAGACT

GCTCCTCCAC

TGACTAGCCC

GGTTAATGC'

ATGAATACCT

GGGGCCAGAA

TCCAAAAGTT

TAATAGAGTA

ACCCCAGCCA

GACCTCCTCC

TGGGATTCCT

GCACCCACTC

GCTJTAGTGGC

TAACTCTTAC

TTCTCTrCAA

CTTAAAACTC

CCTGCCCAGT

ACAGCCACAT

TCCCCCTACC

CTATCCCATT

GGGATTAAAG

TCCCCCAfTr

AAATTGTCTT

AACCCCTCCA

CATCCCAGCC

TGTACTGCCG

CCTATCCAGG

AACCCCAGGA

GGTAGACACT

TCCCTITCTGT

TTACTAGTCA

TCCTCAATCC

TCTGTTCCCA

AAGTGTCGCT

GCTCCTCCTC

CCTATAATCC

TCCCCCACCT

r CCTTF=ICTT

AGCCCACTCC

GGTCATCTTA

AGACTCCGGC

GAGGCAGCCA

CATCTCCAGT

ATCAGGATCT

CCTAAGCCAT

CCAGAGCCCC

TGAAGACTGA

AGTGGAGGGT

GGTCCTGTTT

CCCAACTCTG

TCCCTFrATTA

CTCATTGCTG

17AACCCACA

AAAACCTAAT

CCTGTTATCA

TACCTGTCCA

GCCTATCCAC

TAACCCYFAT

TCTCTFCACT

CAAGGCTTCA

CATAGTTCTT

CTGGCAAATT

T-rCACTGGAT CAGACATAkAT

AAGCACGCAA

TTAGGAAAGG

AGGCCACCGT GGTCAMTCT CCTCTATACA GTCTGATAAT GGACAAGCCT TATTCAGTGA AACCTFCATA CCCCTTACCG TTAAAAACAC ACCTCACCAA GCTCAGCCTC CAACTTAAAA AGGACTGGAC TTCTCAGAAT TCGGGCCTGT CTTTrTATTA GGCCCCAGTC

CCTACAATCT

TACAGTGCTG

ACCCTTAAGT

ATAAAGCCCT

TCCCCAGCTA

AAACAAFI7GC

AAAGGGGACT

CAACATAAAA

TCTGTCTAGT

ATTTATACTT

CTCTCTTAAA

ATTCTTTACT

TCTCCACCAC

TGGCTTTACA

CTGCATATTT

AAAACTCAAG

CCTCGAAATG

TCATTCCAGA

CATACTCCTA

TTCCTCCAAA

GTGGATAGAA

TFJ7ATATTCA

ACTATCAATC

ATYI'CTCTITT

CTACAAGGTA

CACCAGCCCA

TTCACCATTC

CCATCATAAC

GATC'TFCAGT

CTCTTATTCT

TCACTCACTC

CCTCCAAAAT

CAGCCCATTT

ACTTGAACTG

TCAACTACTT

TGATATCTCC

GACAAGGTAC

TGTTCCCATT

TCTCCTAGCC

CACCGAGTCC

TTAAATGAAG AGTGTTGT TTACCTAAAT GATAGAGCCA AAAACCTTGC CAACCAAGCA TITGGGCACTC TAATrAGATG TCCTGGGTTC TCCCGATTCT TAATCCTTTA

CTTATGCAGA

CATTCTATAC

2AAAGAAAGA

GCCTGGTGGT

AAGCACTGTG

CCCCTGCTTG

CCCTJ7AAGAG

CAGCTGAATA

GUrTCATCTA

CCTTGTGTCT

GACAAATGTT

kGTAAAAATG

TAAGATCAAC

AAAATCCCTC

CTCCCCCTGC

GAAAAGGAAI

AAGCCCTTCC

ACAACCCCAT

TCCATTTAGT

TTAAGGGAGG

AAAAGGCAGA

CCCTGACCTA

TCTTGTI'CTG

TTGCTCAATC

TGTTCACTCG

TTCTTTAACT

AATATCACCC

TITCTCAATTC ATACAAAACC AGACCACCCC TCATATTGTC AATGAAATCC ACAGGCAGAC ATCAGTTATG TTATCTATAG TTCCTCTAAT TACCAGTACA AGTCATGACC CTCTCACGCA GAGAGCTCGG TTTTGAGAC CAGTGTCTGA GGGGTT-rTGT CTITACCACAA AATCTTCC-r TAGGTTCTCA CGCCACCCCT AATCCTGCTC GAAGCAGCCC TGAGAAACAT CACCCCCAAA AAT1TTTCACT GCCCCAACAC TTTACCACTA TTTCGTTTTA TrrTTTCTTAT TAATATAAGA AGATAGAAAT GTCAGGCCTC TGAGCCCAAG CCTGCACGTA TACATCCACA TGGCCTGAAG CAAGTGAAGA ATCACAAAAG AAGTGAAAAT GGCTGGTTrCC TGCCTTAACT GATGATATTC CACCAUTGTG ATGTTCCT GCGCCACCTF GACTGAGGGA T-rAACC1rGT GAAATTCCTT CCCCTGGCTC AGAAGCTCCC CCACTGAGCA CCTTGTGACC CCCACCCCTA CCCACAAGTG AAAAACCCCC TTTGACTGTA ATTTCCACT ACCCACCCAA ATCCTATAAA ACAGCCCCAC CCCATCTCCC 'TJ7GCTGACT CTAYTI7TGG ACTCAGCCCA CCTGCACCCA GGTGATTCAA AAGCTFCATT GCTCACACAA AGCCTGTTTG GTGGTCTCTT CACACCGACA CGCGTGATAA 'ITAYI7ATATT ACTTTTAACT AAAACCCMT CAGAGTCTCG CAGGGAAGGC TGTATATATC TCATAAAATG TTGGGGCCCA CTGGATCAGA CAAGGCCACA AAGGCCAAAG GGAAGTAAAG ATCTCATTAT UTCTCCTAAT AMTITCCCTG TCCTrTGTCA TAAATGGTGG GTAGGCTGTT ATGGTGATGG CAGATTCT TTCCATAAAA TGTCCATAAT AGGACATTTG AACAGAAGGG AAAAATCAAA TTGCTGAAGT 165 TGAAAGAGGG CAATGCAAAG AACTTTGGAG AAAGAACTGT ACAGAGAAGT CAACTGGCAG ATGGGAGGAA G1TAAGGGG AAAAATATAG AGCCTCTTTC TTGCTTrCYT CCGACTAGCT AGGACTACAG GTGAACTATr TCTGTAGGAA GGAATGAATA ATTCTGTGTT AGGAGTTATT TCATAAAATG ATCTGAAGTT CAGAGAGAGT TGCCTCTGAC TCCCTGTCCC GiTGCAGTGAA AATCTGAGGG GGATAAGGAC TCAGAGCTCC GAAAGGTAAG ATTTGAGTGA TCATACTTAA GGTACCATCA ATAGGAAGTA AGTCTCAGGG TGGGATTACT AYJTATGTAAT AAATCTATAT ACATCATAAT ATAAACA1TTT TTGTCAGGGT CCTAAACCAC ATGAATGTGA GCTI'TTGCTA TAATACAGAA CTCATAATGT GTGCAAATTT CTGAAAGGGC TCTATTCTCT TGCCATAGAG AAAGAGGGUT AACATTCAYIT TATrGAGTGT GGAGCATGTA ATCTCACTGG ATGTCTAAAG AATACATTTA TTCATTTTCC CTATTCTCAT TAAATCATTA GAGCTCAAGC GTATGTGCTA CTATGCCCAG CTAATTT1T ACTACAATAA TACAGCCCAG GCACATTGAT

ACAGTGCAAT

AATCCTJTCTG

AAAAATTAGA

CT-FGGGTGAA

TTGGACAAGA

CCTCAGCTTC

T-rTTAATTTG

CAAATCAGAA

CCTGGGACTC TGACAATTTC ATGAACTTGG TACTCTGAGT AAAGCATAGG TGGAGCACAA TCATGTGACA AAGATAATGG GATCCCCATT TCATAAATAA AACAACTGGC CAGGGTCACA TCACGGAGAC AGAGGCAGGG TrCCCACTGA AGGCCCTTCC TCCTCCCGCA AGCAGAAGTG CAGGGCAG AGCTGACCCT CTGAGTTCCT ATTGGAACAC AAGTGAAAGA CTTCCTGGCT TCTAATCTCA ATCTGTITCCA GCCTTAGGAT AAGAACCAGA ATCTTACACC ATGAAAGCAT GGAAAAAAAA AAAAAAAGTC TGTGTTTCAG ATTCAGTTCA CAAAGCAGTT CAATAACCCT GTGGGGTAAG CAAGGCAAAT T-FCATTCTTG TTATGGGC AGGTTAAGAC CAAGGTTTCT GGAGAATTTT ATATTATGAA TCYITGATTTA TCCTAAGATC ATATAGGAAT CCTAGAGCTr TACAAGGAGT AGTGTCCATT TGGGTTCCTT TGCCATGTGT GTCTGTGCAC GTGTGCACTG TTTGCACATC CAAGATTTAC AGTGTACTAT TCTGAGATGT CTTTGAGAAA GAAAAGTGTA GTATGAAATC TATATTGGCC ATGGGACAAG CATAAGAATr CAGCTGTTGA CATTAGGTGA TGCTGAAACT TATATCAGCA GTGCACTGTA CAAGTAATGC ACTAGATACT CCAGGGATCT GGAGAAAACA AAACATATGA TAATTTCAAA

GAATATAGAA

GGCCCTGATG

TACACCTCCA

AGGGAGAATC

ATCATUACCA

GAGGTATTTC

TATCTGCCCA

TGCTCTYJTCT

GACACAAACT

ATAACAAACT

GGGTAACCTT

CT'TTATTFTTT

TGTTAGTGGA

GGGGATGTAC

TTTTGCAACA

AAAAATTATT

CAGCTAGCTT

GGTCATCAGA

GATTTATTTG

CTGCCCTGAA

AGGCAAACTA

TCAGTAAGAA GTTAACACTT AAAAAGCAGG CTTTATTCAA ATGCAAAATT GCATGTTACA GCCAGGAAGA GGAGCTCATC ATGGGTTGGA TTAGTAAAGG ACTAGTTATA AAAGAAGTGG TGGGGTTGAG GGAGGCCTGA GATGAAATTT AAAGAATATG TAGAATCTAG GTAAGTGGAT AAAAGGTCTG GGGGCAGGGG AAAGGAGAGC ATTTCATTGT GAATCAAGGA ATTTCTCCAC CTGTTTTAAC TCTTCCATAT GACATCAAAG AGATGTCACT TGCAGCTAGC ATTTCAGTGA TGTTYJ7CTTA CTAATAATAT CGTGATAAAA GAAACATTGA CTATAAGAAA TAGGAATGGG TCTCATAAAA GGAAACAGCA AAACCCCCAA ACTAAAAAAC AGCGCAGGCT ATTTCTCTCT TCTCTCCYI7T TGCTTGGCAC TCATGAGATG CTAGGTGTGG AAGTCAGCCA ACTGAAAAAG AGAGGTGGCT GAAGAAGGTG GGGAGGCTGA AGCCAGTTAA ATAGGATGGT CCAATITCACA GACGGCGAGG

CTACAGTGCA

GAGCGTAGAC

TCTGCAAGAA

AAGTACAGCA

CATGAATCCT

ACCTGTGGGC

AAATCTTCCC

YI7CATGGAAG

AATATGGGTC

Tr1AGTAGTAA

AATAGGACTC

T1TTGAACT

AACTGAGTCC

CTGAATrGAA 17CCCTTrTAT

TGGGGGTTGA

AGATGCACTG

GATTTAAAGG

ATTCATACTG

AGGTAAATAT

'TTTCAACTTG AGCAGGACCC CATTACTTCA CTGGAGTTAG TTCTATAAGA GTGTACCTCC ACAGTATACA GAAGACGACG ATATTCACAT ATGTATCAAA TTTGCACTrC ATTTAGAAGT ACTGAAAACA AGAGTCAAGA AAGAGCAAAG TCAGCCATCT GGTCTTATTT GTTTCTCCTC AGAAAAGACA AAAAGCTGAG GGGATAAATG AGGGGCGAAA TGGAAGCTGA AGGAACTGTT

AAAGAAAGGA

TGAAATTGA

GTCTGTCATC

TTATATTCCA

CTGTATAAAC

GGTCAGGTAG

AAGGAAACAC

ATCTCATGAT

AAAGAAAAAC

TCATTAGAGA

AGACAAGAGG CCAGGCTTTA GGAACCTCTG TCAGATTTTC ATGTGCTTAC CACTCAGAGA GAGCCTGAGA TTCTGCACCC CTAACAAGCT GGAGAAATTT TTGTGGTGCA TACGGTCTTT TTTTAAAT TTATGTTTAT TTTAATTTAA TCTCACTCTG TTGCCCAGTC CGGAGTGCAG CAAGCGAYTC TTCCGCCTCA ACTTCCTGAG TI7TTGTA'FfT PJ7AGTAGAGA TGGGGTTTCA TCCACCTGCC ACGGCCTCCG AAAGTGCTGG 17TGAGCAGT GGAAAGTCAA GGAATTAGAA CTCATGAAAT AGTGGTGGYJT ATAAACTCGT CACATTrAGT TTAAAGAAAT AAGTGACACT AGGAGAGAAT GAAATATGGT ATGTCTTCAC CTCATGATGA ACTGTCAGGG TAAACCACAG

ACTTCATGTT

TT-rTAGTATT

AAAAGATAAT

TGAGAAGAGG

AAGATGAACA

TGGTGTTAAA

CTTJTAGTGAT

GTCTCCAGAT

TTTAATTTAA

TGGCACGGAG

TAGCTGGGAA

CCACATTGGC

GATTACAGGC

GGCATGCTTA

GATAAATTAT

TVTFFGTGT

AGiCACCTTTC

TTCAGCAGCT

TGACGTAGGA GGTGCCACCA CACAAAACGT CCAAGAATTT TCTTTCACCA AGGGCGATTT AAGAGTTTAA AAATTGCAAA ACTTrGGAGTG AGCAAGGAAA TGCTTTCAGC TGGAAATCTC AATGTAAGCA AACCCTAGTA GCAGCACTTC ATGCAGACTC TGATTCAGTA GGTCTGAGTG GC'FrATGCCA CTGGCGCACA GACCCCACTr CTAATGAGTC TGAAGGACAG TGTAGATTGA TTTA~rTATTl TATTTATTTT TGAGATGGAG GCAGCTCATG CAACCACGGC CTCCTGGGTT TACAGOCACO TGCCAGCACA CCCAGCTAAT CAAGCTAATC TCAAACTCCT GACCTCATGA GTGAGCCACC GAGCCCAGCT GTAGATTGAT AATGGAAAGT GAAATTGGAG AAAATTTAAA ATCCTGGGAT ATAATYrTAAT GAGATGGTAA GACACAACTG TCTTATTCTT GGAAAGGACA AAAGGGAGAA CCAGATTCTG AGGAGCTGGT GCAAATGTGC TTGCCAAAAT AGAGACAAAA GAGGT'TGGCA TCATATCTTC CTGTGTATCT ACCAAATGAG GTGATAAACA GAGTCA1T' AAATGITT7CT GAAAACAAAA 1TTCACATAT GCCCTCCTCT TGGGTGTAGC TTCTATCCTG CCAGAATTTA GACAGTAGAA GCAGAAGAGT CAAAATAACC CAGCAAGAAA TGAAACCACA AATGCCCAAG GAGTCATTCA UTCACCATTC AAAAGCTAAT AGAAATGAAC ACAAACTACT ATGAAAATTC ACCCAAGAAC TTAAAAAAAA AAAAAAAGGC TCATGGTGT TAGTGTGATA GTATTCATTT TACCITFrGAC TTGFFCTAAA AACACACCAT ACT'TCTACCC CACCCTTCCT CAGTGCCGTC ACACAATGGT TTCAGTGTGA AAAAAAAAAC CACGTTACTG GAAAAGGAGG GTGCCTGGGA CTTGCCACTC TAAGCTGGTA GTCAAGGGTC TTGAGTTCTA AAAGCATACG CGTTAAGAGC ATGATTCCTG GATCCAAATG AGTATGGATC TCAGCATTGC CAM~ATTGT GACCTCAGGC TATTATTT CTCTGTGCCT GTrCTTAT CAGTAATGAA GATGYJ7CATA GACCC'17CTC CCACAGACTT AAAGGCATAT T-rCATGATT'T AAGACATGTA AACCATTCAT AACAGTATAC AACATGGAAT TAATATTTGA TAAAGGTTITA TGATTATJ7GT AACTAACTCT GTCACTTGCT CAAGGCCTAT AGAAAACYJ7A CTTAATrrAGT TCAACTACAA 166

AAAGAGTTTG

ACAGCCTTGG

GAAGCATTCA

GCCATGGGCT

TGCTTACACA

ATTCTTCATA

ATATAGCACC

TCTTAACTCC

GAAAGCTTAG

GTGAACCATT

CAGTCTCTCC

GCAATTAAAA

TCAGTAGGTG

CCAGAGAAAG

AATAAAAAGA

AACATTFTTAA

CGTCTGACCT

ATACTTACTG

CACACTCTTT

ATTAGATAAT

CCCTCCCTGG

CTJTCTCCTGC

AAGCTCAGTA

GAAGTAAACA

YITAGCCAAT

GTTCCCTAGA

CCAGGCTCAC

GCTACTCACT

TATACATTAG

TGGCCCATAC

TCACTrCATT

TCCTI'CATA

AATGTGATAT

TCAATAAATG

AGACT-rATGT

CAAGAAAGTT

ATT17CCTTCC

AGCAACCTTC

CATrGGCCAT

CCAGCTAGGT

CAGTTTCCAA

AAACTTAATA

TCCTGTGCCT

CAGGTGGTTC

CCACCAAGAT CATATTCAGA CCTAGAATTC AGAGCTGGGC AAATAATTCT TCTTTGCTAG TATTGGGGCC AGCCTTCCT7 TCCAACTTCA CTGCTCAGTG GCCCCTGAAA AATGCTTTCA TACAGACTGC CTTCCTTTCC TGCTTTTCTC TTTATAACAT TTTCTATAAC CACCAAGCCA TACCATGCTC TGCCTTGTAT 17TTCTGATT AATAATTTTC CTGAAATCAG GGACCAGGCT CACAAAAATG TTCAATAAAC AACTATTAAT TAGCAATTTG CTrAGCATGG TAATTAGCTT CAAGGACATC 'ITAAAAAAAA AAAATCTAGT CGGTAGCCAG AAAACAGCTC TGGGTAGATT

TGTGATTCTT

GCCTITCTAG

ACTCCACAAC

TAGTCTCACT

CATATACCTA

AATGACCTTT

TTTTTCTTTC

GACTCCTCTT

TGACTGATTA

3TrGCTAATA TGATCTGCTr

GTGCCAGAAA

ATGAATTAAT

ACCATCTGGT

TCCTCAATAA

ACCATACCAC

AATCCTATCT

TCCTTCTfAA

TATATTCCTG

GCTGTCTCAA

TAAAAAATCA

TTCTTCCAGC

CCATCTAGTG

ATACTTTCAC

GGAGACCAGC

AATTAAAAAG

TUCACAGCCA

AATGCTTGGC

CATCCAGGGG

TJ7CATTACCC

TAGGTGACTT

AGCACTCACA

CCCAAATCCA

CATACACCCA

CGAGT11TGAA AGAAATCTTC AAGCCT1TCC TCACTAGACT ACCTCCACTG ATCGTACATC AAGAGATGAC TGCTTGTTCT CTGTCTTGAT GTCTGCACTG GTTCTCTTGG CAATGTTTGA CTCCTCTTCC TTrCTCCCTGC GATGTTCCTC TGGCTCCCAT ATGATAGTAC CCACTCCTGA ACATCTGTGG G1T-CCTGCC ACAGACATAG CCATTTGCAC TAGTAAAGAG AAGACAGAGT CTCATCCAGT TACCCCTGCC CCACTTCTCC

GTCTCTACTT

CAAATAGTCT

AACCGYI7CCC

CTGGCAACAT

ACTCTCTCCC

GATGGCAGTT

TCTCATCCTC

CCCCACTGAC

C1TFCTTTGT

CTTTTCATTT

AGGTCCTCTT

ACCTCCTGAA

GAGCCACAGT

AGTAATGCTC

ACCCT7GTI7G

TTCCTTGGCA

CTCTTCCCT

CCATTCTTAA

ATGTGAGGGA

GAATGATGTG CATAGCCTCT GTGCTTTGGA TAGGTCCAAT

CAAAACTGAA

OGACTACCAT

TAACAGACAC

CCCATGATCT

CCGCCAGTTT

ATTCAGTTAA

CAGGCGCCAT CGGTTTTAAT

CTGTCTCCCA

GTTTAAACCC

TTTATGATCT

TAAGTTTGTG

TCTAGCATTT

GTTTATTTTA

CTGAGAAATA TTT7CCATC CAC11TGCCAT

CT'TTAGTGAT

GGCTTCTGGT

ATTGGTAGGA

TAAAGGAAGC

CTTAAACTCT

TTCATTTrCTG

AGAAGAAATT

ATGCTCCCTA

GAATAAGCAT

ACAAGAAGAA

TACATAAACT

AAAAGCACAG

TAAATAAACT

TTACCTCCA/

CCAGGTGAGP

TATCACCTCC

CTAATAACTG

ACTGCTCTGC

ATCCCAAAAG

GCCTCATTTT

TGGTTGCCCA

TCAGTTGTCC

CCTITCCTAAA

CCAGGTGGGC

TGAGCTTCAA

TCTT'TCCCAC

TTATTCAT'TF

CACACCACAA

GCCCTT1TrCT

CTCTGAAAGG

ACTATGGGGT

TCTTATTCA

CAAATGCCTC

AGGGTGACCT

ACCTCAAGAT

TCCCCACTT-F

AACCAGCATC

AGCTGGGTAC

ATUCCAGAGC

CATCAACTTT

GACCAAACTG

A3TfCTGAAG TGAACCCATT CTTACTACTA CAAAACAAGT CTCTTFGAAT TATAAGATGC CAGAGGTAAG AAAGCCCATA TCACATGGCT TFCCTTTGCA TTCTAAGCAA CAATCCCYC AGAAATCATC TGAATATGTC ACCAAAGTCC AAGTCACTAA ACCCTAGATA CACATGTCTG CATCTCCTCC AAAAATACTT GCCTCCYJTGG GACAATGCCT GTTAGAGCAA AACCTCTCAT TCTTTTATGT TCCC17CTCA AAGATGATAA U-TGATTCTT CTCTCTCACT

CACTGTGCTA

GGAAGCTGTA

YTGAATGCAA

CTTAAATAAT

TAATCAGAAA

ATTCAGCTCC

ATTTGGATGA

TTTCTCCAGT

GGTAGAATTC

ATAGTCAAT7

ATA'FFTAAGA

AATCTCCCTUr

ACTAGCACCA

GGACCCCAGG

CTCAATAAGT GCTTGTTCAA TTGAATATTTF TGTTrTTTAAC CCTCAGAAAA AATTCTGAGG AATAGGGATT ACTJTGTTCGT TCATTCATTC AAGCTAGTAG ATTTATCACC T-rATCTGGTC TAATGTGTCT AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAATGAAT CAGCAGATGT TTTCTTGCCT GAAAATAGAA AATAGAGAAA AAGGGAGAAG GAAGACTCCC ACTCTCAAAA TATCTGTGTC AAAGGAGATT TGAGGAACTG

GTTGATGCAG

GCCTGGTGGC

GCAGAYJ7CTT

CTCTATGAGA

ACTAATGTGT

TCAGAGCTAG

CT-rCAACCY[

CTCAATAAAA

GACCCGAGTG

CACATFTTTGT

ATGCCTCCTG AGGTTCCATT AAGACCCAAT ATGTCCATTC CCCYI7GAGGG ACAGCTGCTA ATCCACAAGA GAATTTCACT TTTTATCTTA CAAACACAAG ATCTGAGACC CTCTCCTACC GGTTCCAAAT GATTTTTGTA CATCAAGCTC ATTTATITATTC GGTTGCCCAA ATTGGCTTCT ACTGTTCTCA CATTCYTFF G GGAAACTCCT CGCCACTAAT AAAACTTACC AGGCATTAGC AAAAATTAGA CAATTTAAAG CTGTCTTTTG AAGTATATTA GGTATTFGTT GCTTAATAAA CAGTGGTAGA CACTAATACA CCATTCTCCG TGCTACTCAA GAAGACAGAA AAGTGTTTAT CCCTlCCCAA TCTGCCATCT ATACTGTAAA ACTATGTGCC ATTACAGCTC TTGGTCTTGT TGGTAGGAAT TGTGCAGCCT GAATATCACA TGGTTCTCCT TTGACTGGCT AAGTATATAA AACTTTGTGA CATACATT CCCTAAGTTT AAATI'TGGCT TTC1TTTTT ;CGAAGAGCG AAACAACAAA GCTTCCACAG TT-ITCTTACT 11TAATTAA TT[AATTTG AAAAAAGCA GAATATAAAT AAGTAGATAA

TTCTCTTGGA

TTTTCAAGT

AGGTGGACCC

GAACAGACAT

TTGCTAAATT

CATCCTACCT

ACAGCATCAT

CATCTGAGTA

GTAAGGAAAC

TGTGCCATAA

TrTTTrTGTA

CGTGGAAGGG

CTATACTGAA

CTTAAAAAAA

TTCTAGAATC

ACTTCTT17

TGATAAAATA

AATCCTITAA

TGCACTTFGAG

ACTCTITGAG CAGAAAGAAT CATITGGGAG GCAATATA1TT TCAGTGGCTG ATCCTACCCA GGTGAAAGCC CTAT1TTrGCC ACCTGTAGTG TAGTGTGTAT CTAAACTACA ATTTCTTrCAT CTGTTAAAGA GGCATAATAA TTGTATCATC AAATATTrCC AAGTA1TTTAG TTCAGGTCCT AGCACGTAGA CAGTGTTGCA AGTATTAAAG ACTACTATI' GAAATCTT CT-rCTAAAAT TCAGCCTGCT CAGGGGGAAT CAAATCTGAA 1TAATTITCAG ATTCTGGT-rA GCTTCACATA TGAACCTAAC AGCAATAGAT GAGTAAGAAT CTGTTCCTAC TGAGAGAGTT CTAAGGGGGC ATGTGYITCAG T-TCATGCCC TGGTCTAACC CTGTGTGTTG CAACCGAGGA AAAAACCAGT TCACAAATCT GAAGACCAGT GATTTTAGAA TAATCTCTGA CTCTGGGTCC TGCTGATATG GTATTTTTGA GATTrGGCCT TCC~rATTrA CCAAACAGGG CCAATGGTAG TGACTAATCA GAAAATGATA GTCTAGATGA GCCCATGCAC AAGGACACAT GT-rTCTGGAA CTGTTCCTTA AGGGAAAGTC TCCATACTAA GACTACTAGG GCAGGGGACA AAGTGCTAGA

TAAAGTGGCA

TTGAACAGCT

CTCATTGGGT

TTACTGTTrT

GATGACCAAG

AATATTTTTT TTAGGGATGA TCATTGAA GAAAAAGGAA GTTCTGGTGG GAAATTCTTC GATGTATCTG GACTGGAGTC AAAACATCAT TGCCCTGGTT ATGCCTGGTG CACAAAATGT TTCCTfTCCT AAAAGAAAGG GTCAGAAGAT TCATCTGAGG 167 ACAGAAGAAT AGGGGTGAAG GCTCTAGTCA CTTCATTGGC TACCATGCTC TAAATAGTTA CCTGTGCCCT

TTTTCTAACT

ATACATATAC

1TTTATCCT-r

ACCATTGCCT

GCAGAATCAT

TrTTGAGACA

CTGGGTTCAA

GACTAATTTT

CTCAAGTAAT

ACAGATGAAG

GCTTCTGTIT

CACTGATTCC

AT11TAAAAAC

ACATGCAAAT

ATAAATAGCT

TATCCCAGGG

TAGGAAGAAA

AAAACTGTCA

ACTGTATAAT

TAACTGCTCA

CACACACTTT

GATAAGATCA

ATTAGAACCC

ACACACACAT

GTAAATGCCA

CCATAGGAAA

TTGTAAGTTG

AAAAAGCCTA TAAAT-rCTCT CTCTCTCTCT CTCTCTCTCT GTGTATATAT AGACACACAC ACACACCTAA ACACACACAT AGAGATITAT GACTMTTAC TTAACTATAT TTTGTCTTAG AT1TAGCCTG GGAATGTAGC CATTATTTCT AATACTCTTC ATGTTTTAAA GGACCAACCT ACAACTAAAA TCTTTGGAAA GTGAAAATGG AAGATGTTGT TTTATAAATG AAGACTT1F TTTT~rTTTT GGGCCTCACT CTGUTGTGGA GTGATCCTCC CACCTCAGTC TTGTAFFTTT GTAGAGATGT CCTCCTGCCT CAGCCTCCAA ACTATTTAAT GTTATCTTAA TCTTTGYTGG CATAACTGTA

CACAGCAGTT

AACCCCTCTA

GAGTTTGATT

TCCTTATTAA

GGCAGTGTGT

GACAGGACAA

TTCTT1CTrTT

ACTATAAGAT

GTGCTCTCAG

GTCTTTCTGG

TTCAAGTTAT

ATTTTYT AC

CTATTCTTTT

GGTGACTTAC

AATAACCCAC

CCGGGGTCAA

GCCTTAATGC

AGTGAGATTC

GliTATACATA

ATJTGGTTAGA

GTGCAGTGGT

TCCTGGGTAG

GGTTTCGCCA

AAGTGCTGGG

AGATACCCTA

ACTAGCCTAA

CGGTTTGAGA

CCT'TGCTTAT

GATTCTACAA

AGCCCCAAAG

CCTGTTCTCT

GATT-rGAAGT

AGTACTTGAT

AATCAGCACA

GCTAATrGAAG

AAACTTACCT

GCTGTCATGG

CTGGGACTAC

TG17GCCCAG

ATTAGAGGTG

AGCTTCCTAC

CTGCCCGTTA

TCTTGTACAG

AAAACAGCCT

ACACTTATTA

TCCTTAAAAT

ATCCGTCAGT

CTCAATGGAA

ACTTATACTT

GAATT[CTAA

TTCTTGCATA

AGCGCCCACT

CTTACTGCAG CCTFUGACCTC ATGTGCATGC TACCATGCCT GCTGGTCTTG AACTCGTGGG ACAGCCAAGG TGCCTGGCCC CAAGCCAGTG ATCTTTTGGG TCTGTTTCCT GTTTGCCCCA kAATGACTCC AAGGTAAAAA TAGCCAGCTA ACCCCTCACT AAAGATTJTTA GAATTCGGAA TATilTAGACA ATAGCCACCT TCTGCCATCA TCGCCCAAGG AGAATAATCA GTGGTFGGAG AGTACTGTAT AGTACTTAGT 17AGCAAGGGC AGAGACATTr TCAACAATCC CCACCCCCCT ATTCTCAAAT TTAAATGAAA AATTGCCAGT GTAAATGGAC AATTTGATGG AAGGAAAATT AGCAATI7GTT TCGAGATCAT GTCTCACTCT GTCACCAGGC TCAAGTGATT C11TCTGTCTC TTTTTGTATT TTTAGTAGAG GAGTGGCACG CAATTAGGGA CTGATAAATA ATATTTTTGT AGGGGGCAAC CTTTACATAC CATATTCAGT GAACAGAATA CGTACTAACT CCACAGAAAG GCAACACAGA GCAGTJTGGTT AAAATGACAA

CCCTGAACTT

TGGAGTGCAA

AGCCTCCCGA

ACAGGGTrC

CAAAGTGCTG

TGTCCATGAA

AGGCCTGCTG

AGTGATAATC

ATGGTTGGAA

CATGGGAATT

GTATTTGGGA

AATCCAAGGC

CCAGGCGTGG

GAGATCGAGA

ATGGTGGCAC

CGGAGGTTGC

AAAAAAAAAA

CCTAGCAAGC

CCTGTTTTAA

GCTTGGCATC

ACTTTAAAGT

ATGATAAATG

CCTCC1TAAT

ACCAGCATTA

CCATTTGATG

AAGACTGGAC

CCTGAAAATG

GACTGGAACT

TCTGAACTGG

AAGCACYI7GA

TACTTCCTUC

GGAGCCTCTA

CTIT1TACA AGGTGA1TTTG

AGGTACCTGT

GATAGGCCTA

GCCCTGGGCA

'I17GTCATCCA

TCAACTGAGC

GAAACAGGTA

TGGTGCGGTC

GTAGCTGGGA

ACCATGTTGG

GGATTACAGG

TGTITACAGCC

CAGGCTAGTG

TGGGCAGCAG

AGCATATATG

TCTCCCAGGG

GCAGTGCCTT

ATGTAGGCTC

TGGCTCACAC

CCACTCTGGC

GCTCCTGTAG

AGTGAGCTGA

GTATTAAAGA

TGCC'I17GAAG

TGAAGGTGTG

CTGCTTGTGT

TGTGTTCTTT

CCAACCCAGA

CATTGAGAAA

TFCCTTAGT

CCATTTGACA

CAGCCTJTGCT

CACCTAAAAA

CTGAAACACA

ATAATTCACC

YT1ACATG

ACGAATAAGT

TTTGAAAATA

TATTGGCAGA

ATCCCCACAC

TGGCTTrGATG TATCTYrTTT

TCAGCTCACT

TACAGGTGC

TTTTTIT TTGAGACAGA GCAACCTCCG CCTCCCGGGT CCGCCACCAC GCCTGGCTAA CCAGGCTGGT CTrGAACTGC TGAGCTCATG CATGAGCCAC CACACCTGGC CAAAACAGGT YrFGAATGG'rr C~rCCAGGTG AGTTTGGCCA GGTTGCTCAC ACTTTAAAGC TGAGACACAC ATGTTAACTT CTCAAGGCAG TCCTCCYTCT GTGCATrGG TTAGAGCTGT GGCCTTGGTG TTAATGCAAT GCCCATGTGT TGGGAACCAG GAAACCTTAG TGGACATTAG ACCCACTTCC 11AGAGGACA GAGATAGTGT GTCATTTTTT CTGTAATCCA AGCCC'1fTGG GAGGCCAAGG TAACACAGTG AAACCCCGTG TCTACTAAAA TCCCAGCTAC TTGGGAGOCT GAGGTGGGAG AATTGCACCA CTGCACTCTA GCCTGGTGAC

ATCCGCCCGC

ATATCTTAAA

AATGTGGCAC

TCATGCCTTA

CTTTTCCTCT

AATAGATACT

GTGACTCTTG

TAGTGGAATT

CAGAATTAAT

CAGGCAGATC

ATACAAAAAA

AATAGCTTGA

AGAGTGAGGC

CTCGGCCTCC

AGCTGCCCAA

CATACACCCA

AGGTAAAGGG

CCAGTGACGG

TGGGAGAATA

AAGAGGTCAG

GTAGCATTGA

TAAGAGCAGG

ACGAGGTCAG

TTAGCTGGGC

ACCCAGAAGG

TCTGTCTCAA

ATTACATAAG AGCAAAGAAC CATTAGAATA TCTCACTTAG TTrGTTATCAG

GTAATAGACA

TCCTGGGCTG

TGAATCTATC

TCATGTGAAG

GAATGCAGTA

CMrTGTCCA

CTATCTCATG

GATGAGGAAA

AGTCTAATGC

TGTTGGCAAG

GAGAAGAGCT

AGTCAAAGGA

CCAAGGACCT

AAAAGGGCAT

CTGGTATAAA

GGGTCTGATT

TrTTTTAAAAG TTTATCAGAT GAAAAGCGAA AATCAGCCAA ATTTACATGT CTCCAGGGAC TGATGGCTCT AGAATGTAAA ACATTTAAT-r TCCTGTGGGT TTCT-rTTI7T TTTCTTTTTC TTAAACTCAC ATACCTT-rTT ACCATGACTG CCACTGGAAT A.TTCTGAAAG AGAAATCAGT

ATA'TTTGACT

CTGGCATGGG

CTACAGAATC

AATGGTCATC

AAAAGCCTAA

AATCATTAAT

GCACTAAT1T GTrAGAGAT

AAAAAATCTG

CTATCCTTAG

T1TTCCTCC

AAGGCCCCTG

TCAATGCCCA

GTTGTATTTA

TACAACTTCA

GCT-rTTACTT C1T-rCCAATG

ACTCYI'GTAA

TCTCCTGATA

TrCTTCCCAT

AGGCTCAAGT

ACTAGCTAGG

CCTCTCTCTG

GCT-FCTGTAG

GCTA'FrCTrT YrAATCTCCT TGCCAGCCAA GAAGAGGGGG TTATAATCAC AAGGCACATA GCATGAGACC TITACATCTCC CAGTAGTAGC ATGAGTCTAC AGCATAGGCA GA3TJGTGGT TCATAGAGTT GCTCCATGGA CTTGTrCAAT GGAAAAATAA AAGCCAATGA TAAAGCAGTT GTGCAAAAAT CAGTAGTI7AC CACTTCCCTC GTGTAAACTA AG~rCATTTG CTAACATG AAGGAATCTA TACTTTGATG AACCTITFCA TCCCAGGAGC TCCAGACAGA CCTTAAAGGG AAATGTCTCT CTCATCCACT CTACTCCCTG ATCCTACCAT TTAAAGACYTr CACATGCTAG CTTAACATGC AAGATGAACA AGACATGATT GAGTATCCAT TATTTGGGGA GATGMAGAT TGTAGTGGAA CCAAATATAT GA'rrGAGAGA AAGATGAGGA GGAAATGAAC ATACACAGTC CTCTGCTAAA GGCCTCCCTG CGCAGCACAC AGAGATCAGC ATrCTGACA TGCAGATAGT CTCAGGAGCA GACACAGGTA AT-FGC1TI7A GCACCTATTG CCAGGCACTG CYTCTCATAT ACAGATAGAT TT-rGGAGGCA AGTAGGTGGT CATTAGTGAC CTIrACAGG TGTCAGGTGG AGGGTATACA TTAGCTTAGT GATGATTCAG CATrT7CAATG GGCTAACAGA TAGAAGAATG GGTAAAAAGT AAATCAGTGA GTTCAGATTT TAGGAGTTAA GATGGCAAGA GGTGAGAACA 168 AAAAAAGGAA ATGAUTGTCA YFAAAGGAGG AGGAAAGACC AGCCAAAGAT TTACAGTGA GTrAAGCATA CAAATT1TATT TCTAGGCCAC ATATTCTTAG CAAAACAACA TCTGCTCATC CATCAGCTCC ATCGTTAAGA TCAG1TTTT GGACTAGGAT TTGACCAGAT TCCAGATGAT TCACAAATGG CTGAGCAGAT GAAGGTACAT GCAGAGGTAA AGCTGAAGCT CAAATCTGGT GCTGATAGAG GCTCACACTG AATCACTTCA CAGTATTTCT GAGTAGAGAC CCTCCCTTGA GCAAAGGATT GTGATATfrGC TTCCAGGCTT TATTTTCTTG AGAATGATGG AGCATTGAAA GCTGTGGGGA GAGGAGTAGC TACTCCAGGC CTGCTGGAAG TACCATGCCA TATGGCCTCT GCATCAAGGG CCGTT-rCATC TGTTCTGATA TCTACCCAAG CATTTITGAAA T-rCCGTAAAT TCCAGTAGGT GGGUTGACAG YT[-rATAATT AATTAAACTA CTTAAACTAA TGCATCAGGA GCATACTTGT GATGACATTG GTTTYrCTCCC ATATGGAGAT AAGGTTGGCA CTrATTTCAA ACTTGAAAAG ATCAAGAGAT TGTGTTTT7G TGCATGAGGA AAAGTAAAAG TGATTTTAAG AATAAGCCAA CTGGGAAGGA AACTGGTTGG TAYITAAGTAG GACACCACAT AAAATGTAAC TGAGGTTCAA CAAGACATTA TTTATGCAAT ACCATGCTGT ATJ7GCTATAA GTCATGTTAC ACACTGGGAG T-rGTTTGGGA GGTT1TTTCAA AAAAATTTAG YI7AGAATAAG AAAGTTAGGT TAAATTAGGC TCCTAAGT-rT GACTTCTCAG CCCAGGATTG CATGACAAAA CCTCTAGTCT GAAGTTACTC GTYI'CCAAAT GGTCCACAGG TGGTTTCTTC AATCCCAGTT CACTGTGAGC TGAAGCTGAA GTTTCCCAAA GGGTGAGTAC AAGGCTCACA CTGAATCACT TCAATAGGGA AAGAAACAGT GGATTTGAAT CCTAGCCCTG CCACT7GATA ACCATGTGCC TCAGTTTCTT CATCTATATA AGAGGAATAA TGAAATTGTG ATGTAAT-FCA ATTAGCATAA GTCAAGGACC TTAGAACAAA YTAGCTAGTC TTCATATTAT TATCTTCAGC ATTATCTGTA CTGGGAATGA CCAGCTTAGT CGGGAAATAA CTATCACATC GCAAGATGYJ7 CAGAGAAAGA GTGGGTCTCC ATAATAAGCC GGAAGCATTT TGACCTCAAT TCTGTCTTCT ATTCTAGCTC ACAACCCTCT CCAGAAACTG TATCTATTTC CCTGTTCTGA GGAAATCAAA GT'rrTCACAT TTTAGACCCT OCCATOCCAT TCCTCATCTG TCAAATTTAA GCCATTATTG CTACCTTGCT GAATCAGAAG AATTI7TTGTA 1TTTGGAAACT ATATGAGATG AAATGTI7ATC T-fTTCAT[ GATTTAAAGA GTATCTAYI7A GCTTAGATTT CACCCTGTAG GACAAAATGG TAGGTAGAAA GTGT-fTTAAT TGCTTTTAAT TGATCAGTCT CCCTGTAGTA AAATTGTGGA ACTCATCTAA TAAACTATTG CAAGAATCTA AGTTGACAAG TGGAAGACAA ATTAGAAAAA CACTAAGT7G ATG31TGGGGG AGTTAAGAGA GTCTCATACC AGGGTGCCCA GAAATACGAA GAGAAAAGCT GACTGGGAAC AATTGGT~rT YJTAGCATATT TGAGTTCAGA GCTGGAGATA GGCTITATCAG AAAAGTCAGT AAGT-rTGACC AAAGGATACA TGTAGATTAG GCTGAGAAAT TATAGTAGTT TATGGTCCTG GATAAGTGCT GTAGAAAGAA TGAGAAAAGA GTGATATGAG AGAAACCAAG GAAATAGGCA TACCAATAAT TAAAAATGAG TAAAATAGGC GTTCAAAAAT GGGGTGAGGG TAAAGTATTA GGAAGGAGTC ATCTATAGAT CTATITCAGT TGGTTGACAT T-rAAATGTAT ATTGCTTrTT TAAAAAATTA AATTGTCCAA TrCAATTCAG CATTTTGTGG ATCCCAAAGA TOCAATGATA AATAGGACAC AGGAGACGGA CAAGTGAACA GATGACTTCA ACATAAGTGG CAGAACTAAG AAAGCTrCCT AGAAGAAACT GTCTTTGAAC ATGTGCAAAA TGAGAGAGAA GGCCACCAGC AAAGTCAGTG AACTGCAAGA AGGAAAGGAA CTACTAGAAG GAAAAAGCAA GATAAATGGC ATAGTTTCTT CCAGACC7FrA GAGTTCTAAT TCYITGAGAGC GGGAATCTAC CATGCTAATT CCU-ATGGTA TGTAAATGTT TATGTATGTC TFTCCTCATA CCAGGACAAA CTTACTCACT UTGACATATT T1TrCTTCTT CCCAATTAAC TCAGTTCCTT GGCCAGGGGA TGGCTACAGT TCATGATCCC TGAAAAAGA AAAAAAAAAA AAAGACAAAA TTTAGCCAAA GCTGCCTGAC TACATTACTT FGGGTGGTGA ATGAGAGATG AAGGCAAGGA TGCTGCCCTA GCTAAGGTGA CCCTCCCCTf CTCTTATGGG ATATTCTCAG AGAATCTCTG AACATCCCAA TTCACTGAAG CAAGTCCAAC TCAATAAGGG ATTTTGATAG CACTTCTAAG AGAAAAGTTA ACCAAAACTT CGTAAGTTCA GTTAAAAATG AAAAAAAAAA AAAAACCTAC TTTTI'CAGTT GUTATTCTCC TAAAAGTTTA ATAAAACAAC CAAGAAAGAC CTCCACTACC AAAACAGGTG TTATTGAGAG GAGAAGAACC GGCAATGAGA AAAATAAAAA ACACAGTATA ATGGCTTCAG GGGTATTTGG TFTTACTTr TCCTTTGAGA AACATCACAG TAGGTJTAAAC CAAACITCTA CTGAATGTrFC TGACTGTAAG ACCTTGACAG GTTGGTTCTG GAGATGACCA AAGTTTGTTC CTTCAGAGCA GCTGAAGGCA AGTCCATGGT ACCCAGCTCT GGGGCCTCCA ATGGGGAAGA GTTAAGAGGA ACTGACGCCT TTTAAACAAG GTTACTTGAA CCCTCCAACT TTATCTTTAT CAAATrGATA TGGAAACTAA GCCTGACTCA TCAGAAATTC TAAGTAAACA GTGAGAATCC YFAAAGCCAA ATAGGTGTAA AGAGCCCCTG AGTCTACTAG AGTATTGGGA TTCTITGCAA GGAGAGAATA TAAAAGTCTA AGTTCCAGAA T-TTAACTCT TTTGATTTTG TTGGTGGTAC AATAGGTAAA TTAGTAAACA GTACAACTTr 2TAGAGACTT CAAGGAAGAA ALGATTAGGGA GAAACATGGG TATATCAAGC AY7ACTCTGG TTAATGGGTG GATTrGTCATG TGAATAATGT ATTTGAGGGG GAAGAAAGAT AATGACGGCA

TT[AAGACTT

CATGTCTTAT

TGGACTCAAG

AACTAAGAGA

GGCTTGAAGA

TATGTGTGAT

AGCTAATTTA

ATGGTAGTAG

TAAAAATTGG TAGAATGTTA CCCTGCATAA

TGTAAATGGT

ATAGTCT1TT

TCCAAAGATC

AGTCAGAAGA

CATGAAGGAT

ACAAAGAAAA

ATACCAATAA

ATGGCCCAGG

T~rGG'TrTA

GCTCACAAGC

TTACTGATCT

GAGAAATGAG

GATTCCACAT ACTGAGATAA AAACATCCCA AAGGACATCC ACATAGATYJ7 GTGAGTCCGC GCAATATACA AAAGACAAAA CTCAGGAGAA ATGATCACAG GTAAAATGTT AAAAATGAGT CATAAGGGTT AAAAAATAGA GATCAAGTGA AATGAGTTAG ATTCTTTATT GTTTACAAAC AAGTGCCTCA TATATACAGG CAAGAAGTTT TCAGTACCAG GAAGAAATAT GTGGAGCTAT AATGTCTTAA AGATGACATG ITITIGGCC TOCTACAGAG CACATGTGTT AAGTGTGGAG GATACTCT GGGTAACTCA GCCTCCTAAT TAATCTAACA AGCTCATTAG ATCGTGAGCT ACCCTGACAG C=IrATCCC AACACTGTGC AAACTTCATG CTGACTTATG AAATCTTTAC AAACTFCCCA TTTCTCAGAG TGGCTAGTAT TrrCTTGTGGT ACTCAAAAAG GGAAAGGTAA CAATATTGTG

AC'ITGTTGAG

AAAGCAGAGC

AAGTGAGTCG

YT-CTGATCA

CATTGTTC CAACCAGCTr CATGATAAGC TATAATGAUT CCTGTGACTT TACCTAAGAA GAAGCAAAGA AAGGAAAGAG ACTTACCAAA CTGACACTGG GGCCCATAGT ACCCCACATC ACAGTTGCAG GTGTAATrAT TGATGA'TIrC TACACATTCT CCATGGCCAC TGCATGACCA GGGCTGGCAA GAAGCTMAA GGAGGTCAGA AAAAAAATAT TTTAATGTGA TTACATTTTA GTACTCAAAG TCATTTCTTT AGACATAGAT AACC1TUGT CTGAGATGAT TTAAATAATC AGGAAAGGYI7 TA'TI7GTAAA TTCATAGCAT AAAAATCATA TGCTAAAATT 1TfACGTATA AAATACACTA AGCATATAGT CATAGGCATT TATrGCTTT TGGAATGAAA TTACCAATAC TAATATrCTG TAACACTTAT AGGAAACTTA GTGGCATACC TTGAAACTCT TGAAATTACT TGTTITIAAT 169 GAGTGAGAAG G~rAAATGAT GACCTGACCT CAATCATTTC TGCATGCAAT TATTTCTTGG CAATCCC1TT CTTTATAGAA ATCAAAGATT ATTAACTATG GTTCATTATT CAGAAATA'I1 CATACACCAA GCACGCAGCA CCACACTCTC CCCCAGCTGT CAGCTTCTCC TITCCTACGTA GATCTATCAT ilTACACACCA AAAATTCTTA AACCAGAAGC TGTTCTCATC

AAAAAGTCCA

AAAACATCAC

AGATAGTGCA

TACTTCACAA

TCCCCTGCCT

TTrGATGTAA

GGAGTGACAC

CCCCCACCT-r

AGCCGTCTTG

TTTGCCTGCA

TCACCATCTC

AATTTGCTAA

TTGGAAAATG

ATTTTTATAT

TGTGAAAACT

TATTATCAAA

CTTGATTTAG

GATGCAAGAT

TCCATGGGGT

TCACTCCCTA

TCTTTGTTTC

CCCAGTTCTC

AACGGTAGAG TCCAAYI'TAT AAGAGACCAA CTGGCTGTTT TGGAATTGTA GAAGATTTTA AAAATTATAT AAGGTTAGAC CAAGAAGGAA GAGGTGATGT GAGCCTAAGT TTCCAACTGG GGCACTGATT GTCTAGCTCT TCCTCTGTAC

TCCTGAGTCT

TGGCAGGCGT

TGTJTCTTCTT

CACCCACGTC

T-rCTCCAGAT 1TCTAGCCCT

CAGGAAATCT

ACTACTCCAG

GATCACAGAA

ATCTAAGGTT

ATTATTTCAG

ATTTACAACT

TI'TCTTGAAG

TI'TAAGTAAC

ATATACCACT

ATAGGATTAT

TATGGACCCA

TAATATATGG

AATTGATGGT

CAAGTITCTAA

T-rGTAGGGAC

GGCATAAGGA

GAAAGAAGAC

ATCAGATATA

CTCGTATTGT

TAAATATFTG

GGGATTrGT

GAGTTTCTGG

GTGAAATAAT

ACTTAGCGAT

CCATAAGTCC

GATGTATACT

AAAACACATA

ATI17ACATCA

AATCGGTACT

ATAAAACTAT

TATATTTAAT

ATTAGATAGC

CTGAAATGAC

TGCAGCACAC

cT-rAAAGTAT

TGCAAAAGAT

AGCATATCTG

TATTAAAAC

TATCTGAGCA

TCTGCAGCCC

CTGCAGGTAG

TCCTCCTCCT

TAGACTGGCC

CTCTCTTCCT

TCACTCATTG

7FrCT[GTT1T7

CACCCTCCCC

TrTYCAAATAC

AGCAGTGGAC

TGTTAGTGGC

TGGGAGCCTA

GAGGCAGCAT

CATCGTTCCA

GTTGTTGGGC

CATATTCCTC

ACTCAATTTC

TTGCCAGTTC

GCAAGACATC

GCTGAGCTAG

TAGTTGTTTG

CTATTTGAAA

GTGAAATTTA

AATTACCGTG

GCCAACACAT

CTCTITTACA

CAACTCTTAT

GAAATTCATT

TCAAATATGA

CATTCTAAGC

AAAGAGCATC

GAGGGAAAAA

TCAGAAAATA

ATGTGTGAAC

AT[AGTTTAC

AAATTTGTCA

AA31TGTAGAA

GTACAGATTG

GGGGTTATTG

GGAAGAACTA

1TTCCCTTAG

ATATAAATAT

CTCTGGGTGC

CTTAAACCAC

TGTCTACTAA

GAACTGATGC

GCCCTGAATT

TTAATATTTA

GGGTATAGCT

TATATAGAGG

AAATCTGAGT

CCTGTGTAAC

TCTTGATATA

TGCTTCTITCA

CAGTAGTAAG

CTAAATCTGT

GTAAGTCCAG

ACATAATGTT

CTATC'ITCCG GATTCCTATC CGCCTTGTTT TGTATGGCAA ATGGGTTTTT CAGAATAATG AGTGTGACCT ATGCAGACTT ACACTTAGAG ATGAGGAAAC AGAGCCTAAG CAGATTTGAA GTAGAACCTA GACCTTCTGG CAAATTTAGT GGTTTTCTAG GTTTATTTTC ACCAACATAT TTTAGACATT CATATTTCTT TAATATCATA TAACTATACA ATh[ACGTAT ATGTACCTAT GGGAGAAGCA TAATAAGGAC TAAAAAACAT TTTATTTTAC CATAGGAAGA ATATCTAACT GTATAATTTT TAAAAAGAAC AGATCATGT-F CTATACACAA AGAGACTCAA GGGCTTTGAA GATATCTAAT TAAACACATA ATGGTATGAT CTACATGAAT CACTATTTAA ATAAAATAAA CATTTTGAAC AGAGTTTTGA ACTGTTGTGT CCACTGCTGT ATCCTTAGTG TTTGTGCACA GGGACAAATC GCTAGATGTA TTTAGAATG ATTCTCTTAA CCGTGGCCCT AGAGGGCTGC CT-rTAGTTTG GATCTCCACG CAGTCCTCCT GTAAGAGATT TGTTGGTTCC AACGACTGAA AGGCAGAGTC GTAATTGTCT CGGCAGAATC CAGTCGGTTC CATGATGTGC ACAGCTAAAA AGAACCTAGC AGTGTATGTG ACCATCTCAG CTTGAATATA AGATGCTTTT TTATTAATTT TT~rCTCAAA TTTCTTTGTA GCTGTTAATG ACTJ7TTTAAT CCTGGAATCA AGGAAGAACA GTGACATACT ACTGCTTCTG GAAAAGCCCA AATTJ7ACAAA GCCAAATGGT CTGATGATGT TTAATAAACA ATTACACAAT GACTTCATAA TACAGTAAAG AAACAGATAT ATGAGCATTC CACTAGAATG CCTAGCATAA ATTTCACACA

CCTGTTGTAT

GGGAGAGTTA

T[AGGAAATG

CAACAATGGG

ATGACATTAA

TAAGTACCTT

GGATTTGAAC

AAGGTAAGAA

ACTATGTATA

CATAACATAC

TCTGACATTT

ACAT7ITATAG

CCCTGTCTGA

ACAGTITTTGT

TTFJTCTATGG

CTATGTATAT

GAAAAGAGCA CTAAGTTTCT ATGTGACACA GTGCAGACAT GCATGTTTGC TTGGCTAGAG CTGAAAATCC AAAAACCAAG 'FfCAAAGCTA TTGCTGGAGA AGAAGGACCA AAAAATGATA AACCCCCGTC TGTACACTGA ACTATGAATA AAAAATAGAA AACAGAGATT TCTTAATTAA CAY7ATTCCT TCTACAGCAT GGGCTATTAT AGGTTAAAAA GAAAAGAGAT GTTTACAGAA GGGATAGAAT ACTAGTGGAT ITrTAAGAAA AATGAATATA CACAACAGAG CATrGTCCAC CCCCACAACT CCATGGAAAT ATCTGCAAAT GAAATACAAA CCT"TTGAGGT GGTGCTTACA ACTTTCYITAA GGTAACAGGT TI'CTCAGACA TAGATGAAAA TTTGTTCTAT TTTATrTTTA CGCTTTAGTC TTTGGTAATT TrTATACCTG CTTTTCTGCT TTrTTAAAGT A317GTTGCTG CTTAATTAAC

AGGCTAGGGA

GTCTTCAAGA

CCTTAATAAG

AATGAGGTGC

TTATAATTGA

TAGTGTTCAG

TAACAGCTCT

AGTAAAATAG

TGAAGATGTT

ATTATATTTA

TAATCAGAAT

ATTACTTCAA

TCAAGTTGCT

GAGCTATTAG

TATTGATGCT

GT1TATAGCCT CACTCTrGAT CATAATGGGT CAATGCCTCA AATACCTAAA AAAAAAAAAA

CAGACACCAC

AAAGTCACAA

CAACATGGCA

AATTTTAAAA

CTGATT'TCAA

AGAAGAAAGi

CAGAATTGAA

TCTAAACGTC

ATTGAGCCTC

ACTGCACTGA

CCTCCCCMT

TCTATTGCCT

TCCCTCCT[

TTGTTGCTGT

TGTYI7GGTTC

TATCTTTITC

TACAAATCAA

TTGACTCG'F

ACTTCCTGAA

CAAGTACCYI7 GAAAGAAAAG TATTTCTTI'T TTTAATAAAA AGAAATACCT ATI7TCCTGCA CACCTTAAAA TATACTTAAT GTAAATGACG CATGTATACA TGTGTGACAA ACCTGTATGT TGTGCACATG AAA11TCTATC TTCCAAAGCA TATCACTTCT CAGGTAGACA TAGTATCT TCAAGAGTCT CCCCAGAGAC AAAGTCAAGA T[fTCAGGATC ACTThFTTTG AGGGTCTGAG AAAATGTTTA ATGGGGTGAT TCCTATCCTT GCCACCTGCC TCTACAACCC TTTrTAGGCTG AAAGGCTCAC CATGGCTTTG CTTGGTCCTT TrGACT7AGC ACAAGGGTCT CAGGTCCTTG CCCAAAGGGA ATGTCAACAG AAAGCCTTGC TTTCTT7TCAT

TCCCTCCCCT

CCCACTGAGA

CTATCCTTCC

TCTTCTTCCT

TTGTTCTCCT

ATAAATGCTA

AACTGCATTT

TCGGTTCCTT

GYrAACCCCT

TAATATTCTT

TCCTCCTGCA

CAAAAATGAA

TrCCATTCTC

C'ITCTITFTC

CTTCCTCCTr

AACTAACTCT

CAGACATATT

CACCTCCGTC

GAAGAGAGCC

GGACTATAAA

CITCTCTTTC

CTGCTGATCA

CTATGCATCT

CTCCTGCTCC

CTCTCTCTCC

TGGCTACCTG

TATGATGTTT

TTTCCTTGCT

CATGCTCTCT

ATGAGATGGT

TTCTCTAACC

CTCTTT~CCCC

GAAAGTAATG

TTCCTTACCC

TCTJTCTTCTA

TCCTCCTCCT

TGGTAAATGG

GCAAAACTTC

CACCACCTAG

AGC1TrTCAC 7TI7ATAAGAC

AGTCAATGAG

TTITTGAGCAA

AGTTAATGGG

TACCCTAGAA

CAGTGYI7TAT

AGAGGAAATC

GTTTCTATAT

CAAGAGTTTC

CTCTAGTTCT

GTGTGCTGTG

CAGTCTCACA

ACCCC1TICC

TGACTAGATT

TCCTCCTCCT

CTTGTTCYITG

TCTTCCAC

CCCT-TGGAAA

AGTAGAGCTA

TGGACGTCCT

CGTGTAGGTT

TGCATGTGAA

TCAAATGCAA ATTAGGACCC ATATGATGAA GGACAATAAA AAGGAAGACC CACTGATGTG 170 ATCAGATTTG CATTTTTAGG AAAATAATAA TAACAACAAC ATTATATTGT TTAATCTT-rA TAACAGCTCT CTGCTATAGA CAAAGAGGTT AAGAAACAAA T-TCAAAAACT AGCGAAAGAC AGGAGGTAGA GACACGAAAA AGCCTTCAAA AAATCAATAA AAAATAGATG GACCACTAGC TAGACTAATA AGAAAGAAGA GGATATTACC ACTGATCCCG TAGAAATACA AACTACCATC AAACTAGAAA ATCTAGAAGA AATGGATAAA TTCCTGGACA AAGTCAAATC CCTGAATAGA CTAATAACAA GTITCTGAAAT AAAAAGCCCA GGACCAGATG GATTCACAGC CAAATTCTAC CYITCTGAAAC TATTCCAGAG AATAGAAAAA GAGGAACTCC TCCTGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA CATTGCGAAA ATACTCAATA AAATACGGCA AACTGAATCC ATCAAGTTGG CTTCATCCCT GGAATGCAAG GCTGGTTCAA AAAAACTCTG AAGCTCAGCG CCCCATATTT TATGATTATT ATCCCCATTC TAAAGAGTCT AAGAAATAAC TAAGATCAGA GCAGAACCAT ATCCAGGAGC TGCATTrTGA AAAGATTAAC ATCAATAGAC ACAATAAAAA ATGGTAAAGG AGAGATTACT ATAAACATCT TTACACAAAT CATACACCCT CCCAAGACTA AACCAGGAAG TAAGGCAGCA ATrAATAGCC TACCAACTAA CAGAGGTACA AAGAGGTGCT GGTACCATTC TCCCTCACTC ATTTTATGAG GCCAGCATCA AAATTTCAGG CCAATATCCC TGATGAACAT AGCAGCACAT CAAAAAGCTT ATCAACCACA CATACACAAA TCAATAAACA GAATCCATTA ATAGATGCAG AAAAGGCCTT GGATAAAATT TTGATGGAAC GTATCTCAAA ATAATAAGAG GCAAAAACTG AAAGCGTTCC CYJ7TAAAAAC ACATAGTATT GGAAGTTCTG GCCAGGGCAA GAGGAAGTCA AATTGTGTCT GYITTGCAGAT AAAATCTCCT TAAACTGATC AGCAACTTCA AGAATTCCTA TACAGCAATA ATAGACAAAC ACAAAGAGAA TAAAATACCT AGGAATCCAA AACCACTGCT CAAGGAAATA AGAGAGGACA CGTAAACAGA ACCAATCACA CAACACCCCT TCATGCTAAA CTATTTATGA CAAACCCACA TGGCACAAGA CAAGTATGCC TCAGGCAAGA GAAAGAAATA GACATGATTG TATATITAGA GCAAAGTCTC AGGTTACAAA AGAGAGCCAA ATCATGAGTG CYI7ACAAGGA ATGTGAAGGA CAAATGAATG GAAAAACATT CAAGGTAAY[ TATAGATTCA AACTACTTYUA AATTTCATAT

AAAACCACGT

AACTCTCAAT

GCCAATAGCA

TCTCTCACCA

AAGTGTATTC

AAATCCCA11T

ATCAATGTGA

AACTCCCATT

CCTATTCAAG

CCATGCTCAT

GTGCTATCCC

GJGAACCAAAA

GATTATCTCA

AAACTAGGTA

TACTGAATGG

CTCCTGTTCA

AAATAGAAGA

GTCTCAGCCC

AAAAATCACA

CACGATTGCT

GAGAACTACA

GGGTAGGAAG

CATCAAGCTA

AAGAGCTTGT

AAACTATACT

AATCAATATC

CTACTGACTT

ATAGCCAAGA

ACAAGGCTAT

ATGAAAATGA

TTTTCACAGA

CAATCCTAAG

AGTAACCAAA

CCATACTGCC

ATTAGAAAAA

CAAAAAGAAC

ACAGCATGGT AAAGCTGGAG GCATCATGCT ACCTGACTTC GCTGGTACAA AAACAGATAT ATGGACCAAC GGAACAGAAC AGAGGCATCA GAAATAACAC CACACATCTA CAACCATCTG ATC1TTTGACA AAGCTGACAA AAAGAAGCAA TTGGGAAAGG ATTCCCCATT TAATAAATGA TGTEGGGAAA ACTGGCTAGC CATATGCAGA AAACTGAAAC TGGATCCCTT CC117ACACCT TATATAAAAA TJ7AACTCAAG ATGGATTAAA GACTTAAATG GAAGACCTAA AACCATAAAA ATTCTAGGAG AAAACCTAGG CAATACCATT CAGGACGTAG GTATGGGCAA AGACTTCATG ACTAAAACAC CAAAAGCAAC AGCAACAAAA GCCAAAATTG ACAAATGGGA TCTAATTAAA CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT CAAAGTGAAC AGGAAACCTA CAGAATGGGA GAAAAT'TrT GCAATCTATT CACCTGACAA AGGGCTAATA TCCAAAATCT ACAAGAAACT TAAACAAATT TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA GGATATGAAC AGATGCTTCT CAAAAGAAGA AGTTTATGCA GTCAACAAAC ATATGAAAAA AAGCTCATCA TCACTGGTCA T[AGAGAAAT GCAAATCAAA ACCACAATGA GATGCCATCT CATGCCAGTT AGAATGGCGA T[ATTAAAAA GTCAGGAAAC AACAGATGCT GGAGAGGATG TGGAGAAATA AGAATGCTTT TTACAGTGTT GGTGGAAGTG TAAATTAGTT CAATCATTGT GGAAGACAAT GTGGCGATTT CTCAAGGATC TATAACTAGA AAAACCATTT GACCCAGCAA TCCCATTACT GGGTATATAC CCAAAGGATT ATAAATCATT CTACGATAAA GACACATGCA CACTTATGTT TATTGAGGCA CTATTCACAA CAGCAAAGAG TTGGAACCAA CCCAAATGCC CACCAATGAT AAACTGGATA AAGATGATGT GGCACATATA CATCATGGAA TACTATACAG CCATAAAAAA GGATGAGTTC ATGTCCTTTG CAGGGACATG GATGAAGCTG GAAACCGTCA TTCTCAGCAA ACTAACACTG GAACAGAAAA CCAAACATTA CCCATTCTCA CTCATAAGTG GGAGTTGAAC AATGAGAACA CATGGACACA GGGAGGGGAA CATCACACAC TGGGGCATGT CAGGGGATGT GGGGCTAGGG GAGGAACAGC ATITAGGAGAA ATACCTAATG TAGATGACAG GTTGATGAAT GCAGCAAACC ACCATGGCAC ATGTATACCT ATGTAACAAA CCTGCACGTT CTGCTCATGT ATCCCAGAAA TTAAAGTATA ATTTAAAAAA AGTTTAAAAA AAGAAAGTTG CCTFTAGTCAC ATAACTAGTA AGAGACATGG TTGGGAATTT GAACAGAGGC CAATCAGTTC CAAATCCATG

CTCTITGATCA

CAGGGAGACT

AAGTCCTCTC

TCAGGCTAGA

TCCCTCAGCC

ATT-TTGTAG

CTTFTCAGCCA

YI7CTCCATCC

TATCATGTGT

GCTCTI'CTGT

GCGAACGAAT

TCCCCAAACA

CTCCTCCAAT

ACTCAGACCA

AACAAATTT

ATATTTATTA

AAGTTACCTT

rTAAGCTGAA CTTATGGCAG GAACTTGGAA GACATGGTAA AATGGGGAAA AACGTGGAGC TGTGAAAGTG CCAGTGCTCC CACTATACCC TGAAAGAAGT ATCTAGACTT ACTFI1TTTCT

CTCTAA'TTCT

GTGCAGTGGT

TCCCATGTAG

AGACAGGATC

CACCAATrCC

TCATCTTACT

TGATTCTCCC

GTCTAACCTC

TCTAAATTCT

AATTTAGTTG

CTGTAGGGCT

AAAC'TrTGG

GGTAGTGGAA

TTTAGGTGCA

CTCAATCTCT CTCTCTCTTT CTCTAAGAGA TGGGAATGCT GCTCTGTCAC

GCGATCATAG

CTAAGACTAC

TCACTATGTT

CTGAGACTGC

TCACCAGGGA

TCATCTCCCC

ACTAACTTGG

GTACAACCAG

TTCAATAAGC

CTTCCCACAG

AGTTAACTGA

ATATTGCGGG

CTCATTrGCAC

AGGCACATGC

GCTCAGGCTG

TCTCACCAAG

GCTCCTGGTT

AACCTCCAAA

TGGTCCAATT

AACCATICTC

CTCTCATATT

CCTrTCCATC

GACACCTCTC

TCAAGGAATC CTAGGGTCTA GTGCCCCTrC CCCAACCCTC GACTAATTTT TTJTATT-FTTT TAATTrCTGTC

GTCCTACACT

TTCCTCCTAC

CCCTTrGGAGT

CACACTCTTG

CTGTAGCCAA

TrACATATCC

TCAGTGGATT

TTTTrTTTCA

TTGAAGCTTG

TCACTAACAC

TTCACTGGCT

ACTCCAGAGA

ACTTTGAATA

ATGCCTACTC

CAAACTGAAC

ATAACTCCAT

CAAGTCATAT

GACCGATGGG

TGAGCCCTGA

GGGGGAAGCA

TCCAATCAGG

AAACAGCCTA

ATTTCTTCTG

TCACCGCTTT

CCATTTAAAT

AACATCTCCA

TTCTGAATTT

CCTTrCCAGTTr

CCAATGTGTC

GTTCAGGAGG

ACAAAGAGTT

TACTACAGAA

ATTrTTTTAAG AAATCAGAGA CTGGCCAAGT CAGATTAACA TCCAAAGGAC TTAAGCATTT TGTGGGGTGG GAGAGAGGGG TATCTGTGCA GTGAGAAATA AAGACAGTTA TTrcAAT"TAAT TGAGACATGC ATTACATCAT rrCTTACT'rr TCAAGAAGAA ACATGTTrG CGACT[GAGT TrATCTGTCT AGTGACC11'G CAGCTGCACA GCTAGAGAAA CAGGGTCYI7C ACAATGCCTG GGAAAGGAGG AGAGGTAAGT CTCACTAGCC ACAGAAAAAC AGGCAGTTAA 1TTAAAGG 171 GCTCCAGCTC ThrCTCT-rTC TCAGGGGGAG TTGGGTTTTG TATrTAATTT CTrTTAAT-rC CTGTTCCAAA AGAAGCCAGA 17TATATGAAA CATATAGAAG AGGTAAATCC ATAGAGACAG GAAGAAATGG GGACTAACTG CTrATAGGGT ACAGAGTTT-r GACATT17T TAGGCCATTC TTGCATTGT-r ATAAAGAATT ATGT-rTAATT GGCTTACACT TCTGCAAGCT TTACAGGAAG AAGGCCTCAG GAAGCTTACA ATCATGGCAG AAGGTGAAAG GAGCAAGAGA GGGATGTGGG GAGGTGACAG TCACTT17AA ATCATGAAGA CAGTACCAAG AGGATGGTAC TAAATCATTC CCTCCCACCA GGCCCCACCT CCAACACTGG GGAUTACAAT CCAAACCATA TCAGAGATGG TGGTTATACA ATGCGATAAA GTTT[ATGTT GTGTGAACTT CACCTCAATA AAAAAAAATA GGAATAGGAA AGGTCATGGA GATATATTAA CAGCCATrTG ACTGTTTTGT GGCCCTCAAA AGGTAGAACT AGATCGAGTT TGGAGAGAGG ACCCAGTGCT GAAGAACCGT TTGCCTGCCA TTACATACAA CTGAGTTrTCC GCTTACACAT TACAAAAGGT TACATGTTGT CTGATTCCAT AAAGTAGATT AGAGGTTCCC AGGGGCTGAG CTTCTGATAA AAATA1TIG GAACTAGATA ACCTGAGACT TGGTAATTTA TAAAGAAAAG CATGGTGCCG ATATCTGCTC AGCTTCTGGT GGGAGCAGGC ATATCACATA GCAAAAGCAG ACAGCCAGAT CTTGTGAGAA CTCATTCACT ATGAGAAACC CCACCCTCAT GATCAAATCA TTGACATGAG ATTTGAGTGA GAACACGGAT CGTCACTGGA TTGTACACTT TAAGATGGTT T1TAATGTAC

ATGGGTGGTA

GGTGAGCATT

TGAGACATGA

ATTGAAAGCA GCATCCCTGG CTCCATTACA GATGACCGCA TATCAGTTTA TCATGGGTAA CTATCAGGAC AAATCACCAT

GTCCAAGGGA

AGATTTATTT

AAGGAATGTG

GGCTCACATT

TGGTCAAAGG ACCACTACCC TCTATCTCCT ACACAGFJTCA CCTAAACTGT CTTGCCATCT CTGGGATTCC TGTCTTCACC CT-FlTCTCCT ACCTCCTfGC TTTGTCATTA TCTCAAGATG ACAATATTTA T-FCTCCACAC CTTTATAATG AGTGCCTCYF ATATATGTTT CAAAGAAGAA ATAAAATAAC TCTGCTTCTT ATTGTAGTGA CCTCTCAACT CCTCATGCAA TAAGCACTTC TCATAGTCTT ACGGGACTTC GCTCTCCAAT GACATT-rTCC TCCACTAGAC AACACCTAAG ACTGTACCGT CTCTAAAGTC TCTTGCAAGT GTATTGCTCA AGTATCTCAT ATTAAACATT TCCTTATTJ7C TAACCATCAG T[TTTrrT-[ TTTGAGACAG GGTCTCACTC CTGCAGCCTC CATCTCCCTG G'TrCAAGTGA GCATGCCACT ACGCCTGGCT AAGATTTTGT GGTCTCGAAC TCCTAACCTC AGGTGATCCA GCCACTATGC CCCACCTGGT Tr1CTCCTTAT AAAAATTATA ATAGTGAGAA AATTATGACA ACCTTCCAGA CTGCCC'rrAA TAATTCCTGA 'ITTAAATGAT AATAGCCCTT CTCCAAAACT GGTTAGGAGG ATGAGAGGAG CCTGAAFFCT GAGGTCACAA GATTTGCAAC ATCGCCAAT[ CYTrT-GAGAT GTCYUITCAG ATITCTTACAT TGGCTCCACC CAGAAGCAGA CTFAACATGC CAATCAGCAG CAACCATTCC TCTGCCTGCC

GCTCATTGCT

CAGTAGAGAA

TCCTrACATT

TCTCTCCTGA

ATCACCAAAC

GCCCGACTGC

AGCACATACT

ATTCATCTGC

TGAAGCTTGT

GATTGGCTf

ACCATCCATG

TTGAGCTACC

ACATGTTCAA

TGCAATGCTT

GCCAACCAAG

CTAACTAACT

TGGCATGTAA

CCCAACCT7rG

TCCCCTCAAT

CTCCCTAGGA

TCAGGGTfGG CCTCT-rGTAA

GACACTGAGA

GGCACCTAGT

GCACAACCAA

TCC'FI7CCCTA ACACTrCACT

TTTACTTCTA

ATTCAGCCAA AAGAAGAT AGGAAAAGAG TGGTTATTAG ATAAAACCAT CACAAAACCC GGGAAGTACC AGTGAATGCC AACCCTTCCC TAGCCTACGC GCTGCACTCA CTGCAGTTGC GCCCACCTAC CTCCACAATC GCCCCTCFFA CTGTCTGTCA ATTICATCC CAAATGCTTC CTTCCAGTrr CCTGTTCAAA CATCACT-TCC CCTGCAGATC AAGGCAGGGG CAATCTTCTC AACACACACA CACACACACA TAAACCATCT CACTGTCCTC TCCTGATCTT CCTTTCCCTG TACCACAGCC CAGATCCTCA GGCACAGCCT CAACCTCGAC CTTTAACCAC TGTCTCCTAT CCTCA'FrGAA CCTCCAGGCC GTTTCTCCTT ACTTFGTTTGT TTGTrTTATTT TGTTGCCCAG GCTGGAGTGC AGTGGTATGA TTCTCATGTC TCAGCCTCCC GAGTAGCTGG AT'ITTTATT'A GAGAAGGGGT TTrTGCCATGT CCTGCCTCAG CCTCCCAAAG TGCTGAGATT TTA'FITCAAG TCTATGCTGC ACTATTAAAA GTGAAAGAGA TCTGAAATAA TCAACCCCCA GCTTGGGCCA AGCTATCTrT GGCAGAAATT AAACTGCCTT TGTAAAACTA ATAAAAGACC

GCTAAGGTGT

ACTCCTGCAG

TTCAACTGGT

ACAAGGACCA

AAATTATCCT

AGATGTAAAC AATTACCAAC ATAACAGCAC TATCATAGAA GGCTCTACCT GGACCCATCA TTTTFCCACAC CGCTATGATT TGAAAAATCT TAGCCTTAGA GTTTCTrTTTT TrCTCGGCTCA

GACTACAGGT

TGGCCAAGCT

ATAGGCATGA

CTGCCTTGAC

TCTTGCCTTTr TAGiTTATAG

ACCAATGAAA

TGTTATTCCG

TCTGATTGGC

ACAAGTCCTG

GCATCCCAAC

ATTTTGGGGG

AATTCT[CT

TTGGACAGTT

GTTTTCTTGA

317GCTACAGC

GTGCAAATGA

AACGGTGGCA

TTTTCAGTAA

AGGCTGATTT

CTATTGCAGT

ACACTGTTGG

TATACAAC

CAGTACATAC

ATGT1TACCCA

AAGCTCCAGA

TTTCCAAACC

TCGCTCCCAA

AAGGTTTrATA

CAAAGATGTA

ATGGGCCCTG

CTCTCTGTGT

TGAGACAGAG

CTCCCAGGCT

CCCAGCTAAT

GACCTCGTGA

CT-rGTGTGGA

ACTGTTTACT

TI7GTGCTATI7

CAATGATTFCC

ATATlAAA1T

AGACCACTCA

CAGTAATAAC AAAACCCCGG TCTCCCATTT GGCTGGCTCT GCATGAATTA TCCCATCTTG ATAAATCACC TTTATCTGGG CAGCAAACAA AAGGAACCCA CAGATATATC YJTGCTTCCAA AATTGGATTT TTGTTTAATG AATTTATTCT TGTGAATGYI7 GTGTCTGAAT TCTCTTTATT TCTTGTTrGAA AAGAACTATA AGATGGATAG CTAATTACTC AACACGGGGG GATGTGACCA TCACCGCACT TI7GTCCACTT TflCCCAAACT ACATAGTGTT ATATGGTATA TGACCCAATC AATACCACAT AGACATCAGG GACACTTTAA ACTAATCAGC CTATAGTCCT

TGGTTGTGCA

TCCTACTGAA

TAATITGAGG

TTACCATGTA

AAGCTTAATTF

ATGTGTGTGC

TCTCGCTCTG

CAAGCGATTC

1TTGTAT

TCCACCCGCC

TGTTAAGC

CTATGCATCT

TITACACCTC

TACAAGCCCC

GCAAACTGGC

TrCCATTTGT TCCAAATCAC TTGGTAACAT TAAAAAAACA AAAAAATATA CACGCAACAT TCAGAATATT TTGGGTTGGT TCTCTCTTTG AGAAAAGGAA AACACATTCC TAGGACCCAG YrCA'FrATCT TCAGGGCAAA TCAGGAACAT TCAGGAGTTT CGTAAAAGCG TCTTGCTT-T GCCCTTGTAA TAAAGGTT TTACCTGTGG GTTAGGGT -GTGGATTTTT TITrmT-Mr ACATT1AGCAT

TCGCCAGGCT

TTCTGCCTCA

TFTAGTAGAGT

TCCACCTCCC

TCCCAGGTGA

CAATATFF

CTT=FAAA

ArI1TCTGTAA

GTACGCTTGI

GGAGTGCAGT

GCCTCT'TGAG

TGGGGTrCG

AAAGTGCTGG

GTGAATACAA

TCTTTAGTA

AAATITT'TrC

ATGGGGATTG

GGCGTGATCT

TAGCTGGGAC

CCATGTTGGC

GATTACAGGC

AACTAGATCT

TCTTTCCTTT

CC1TrrATTT

AAATAATTGC

CTGCTCACTG

TATAGGCACG

CAGGATGGTC

GTGAGTCACC

TTCCCT-rCTG T-rCTCTCTTA CTATrGACCT TGGACT1TG

TTCAGGGTCC

ATAGATCTTA

TATCTAAGTA

AGGAATATAT

TFTr'rrTTrC

CAAACTCCGC

CACCACTATG

TTGATCTCTT

ATGCCCAGCA

TAGCATCTGT

TTACTTCCTC

17AGCCCTCA

AGAGATAGAT

AGTAGTGGGG GCAGTTFGATA CATAACTAGG T1-TAAAGTC TAGCCTTCTG GAAAAGTGAT TCTACTTCTT ATTATGAGCC AAAATATGCA TTCATTCACC 172 CATGCATTGA TTTATTCA11T CAATAAATAT TGGGAATACA GCAATGAACA AGGTAATTTT GACATTAAAC AAACAATTGT TATGGATTAT GAGGGCATTA GTTGGAGTTC TCCAGAGAAA GGGGTGTGGG GGTGTGGTAT CCTGCTGTCT ACGAGCTGAG

GCAAGTAATA

AAGAGGAGAC

CAGAACCAAT

YTFTTATAGA

AACCAGGAAA

AGGAGAAGAT

GGGTTGGATC

GAGTGCCAGT

GCTCTACATA

CAATTAAATA

AGAAATCTTC

GGAAAGTGAG

TATTGTCAAC

Tr1ATAAAATA

CACAGCTAAT

GTATFTCCATA

AGAACCTCTG

GCCAGAACTT

TCACACTCCT

GAAAACTGGA

ATTCCTCTCT

TCGTTAAAAA

ATACAAGAAT

CTGTATTCTT

T-rcAAAACGT

TATACAAACC

CACTCAGAAC

317AAAACAGA

ATCATAGTTG

GATTATAATA

ATAGGGATGA

AACAACCCTC

GTTGGAAGGC

GGGCCTCAAT

CTAATCTCTT TGGAAATACT TGGAGTTAAA CAATGGTGAT TTTTATCTAA ATAAAATTTC CYITTATAGTG 117ATGTCAAA TTTTAAGTTA TAATTTAAAA TTCTAATGCA GTrTACATAA CATAGCCTGA TCACAGTAGT CTGTTCTGAT CC'FrATCACA CTCTGAAACT TT-rTTITTCAA CAAGGCTAGA GCAGCTT-rGG GATTCCT-rTG GAATTGTTAA TCCAGAGCAC CCTAACATAC TTGT-rGGATG

TCCCTACCCC

ATCTATAATT

CTAGTGTAAG

GGTGTGTGTG

AATTGTCTCA

GCCAGTGGAA

GGGTGTCCCA

ATGGCCACCC

CTCACAGACA

AGCTGTACAA

TAAGAAAGAG

TAGGTCTGAC

TTCTCAATAA

ATATTTACAA

TGTTCTCTCT

TCTCTGTTTI'

CACATGCTAA

CAATTACTGA

ATCTGCTTAT

AGAAGAAAAC

CATGGTGAGT

GACAAACATC

ACATTGGTGA

CACTGAGAAA

TCACATACAT

ACTTAACACA

ATAAGCTTAA

AACTCAAACA

CACTTAAACA

TATTTCCCAG

GACTGTTGGC

GTTAATGGAA

CTGAGAATTT

AAATAAACAT

AAATAGGGAA

TJTCTATTGTG

TTTGTAGGAA

AGGCAATCCT

TAATGTTTTA

TTTTAAAGGG

GAGATAAACA

ATAAATATAT

CAAACCACAC

ATYI7CAAAGA AGTTrTTTCTG TTTGTI17GTTG

GTGTAGGAGA

TTCATTGCCA

AAATGCTTGC

TAACTATTAG

AATTTAAAAT

TGCAAAGCAC

TGCA1TTIATG

TCTGAAAAAA

CTTAGTCTAC

TCAGGGTGAT

TGCGTJTTTAT

TAAGCACATT

ACTTTAAAAA

TGGTATTTCA

AAATAACACT

CCCCTTTAAA

CCAGTGTTCA

GT1TTGATTC

GTGATCAACT

TCACACAGGC

ACATCTTCAT

CTTCCATAAT

ATCCATCTTT

CTTTTATTAG

TATCTGACAA

GTAGTAAAAA

TGAAATAAAT

CTT-rTACCAT

AAGTATGGAA

ACTGAATCCC

TTGCACCATT

TCCACTCTGT ATCAGGAATG TGCTAGGTTC TAAGGAACTT AGAGTTJTAGT GGGGAAGACA ATTrATTACA ATTAAAGGAA GGAAGAGACA TAGCCAGTTC TCGTGAAGGG ACATGTATTrA TGTGTGTGTG CGTGTGTGCG TGTGTGTGTT CACAATTATG GAAGCTGAGA AGTCCCATGG TACTTCAAAG TCCAAAGGCC CTGGAACCAA GCTTAAAAAG ACAGTGAATT CACTCTTfTT

TCTACCAGAT

TATGTTTACA

TTCCAACAAA

TTGGCCTCAT

TTCCATTFCAG

T17TATTCTGG

TGTAACATAA

ACAGCATTTA

TATTCAATGC

AAGTGATTAA

CATGCATTTG

GACTCTrTTA

TATCATATCT

GACATTCATA

GGAAGTTTTr TT-fTTACTCT

TITAACATCAT

TrTGTTAATA

CAAGTTTTTT

AAGTAAAAAT

ATTGTGCATA

CCTGTGGGCA

AAATTATACC TTTGTGTGTT

CATCGTGGAA

CCAATTCTAC

GCCTTGCTAG

AACAATGAGG

AAGTCCCTAC

ATCACAATCC

GTAACCCTCG

ACCACATATT

CATGTTTTCA AAAAACAACT GGGACAATAG TTTCCCTTT GGGTAATCTA GAATAAGTAA CACACTTGTA TTGAATGAAG TTAAGAACTC TTTAAGAAGC CACAGAGCAT TCAGTAGGAT TTCAACATCT GTCATTTTT TAAGTTATAA TATTTTTAGT CATTTTrTTC CTCTAAACTC TGGATAATTA TTATTCATTC TTATGACAGC AACTGTGTAA AAACACTGTG AAGGGCAAAA GAAAGAAAGC CACAAAATAT TGTGTTTCTG TGCCAAGATT CAAGGGAGAG TTAGAAAAGG AATTCTGAGA TTTCAGAGTC TTGGTCTCTT CACCTTTGCT TATCCTTTCC CTrCA'ITAGC CAACACTTTC TTGATCCTGA GAGTAGGAAA GGGAACACTG GTTGAAGGCC GTCCHTGCCT GCTGGACTTT GATCTATTGA AGTGGTGATG GGTGTTGCGG AAAGGCATCT GGCATAGTAG GCAAGAAGGG CCAGAGACCC GAGGAGAGTT ATCTGTCTCT GTGTATCCCT CTAGYITCCCC AGATGCACCT GTTTCTGTAA ATATAAACAT GCATGTCATC ATAT!7CTGCA TACTGATCAT GACAACAAAA TGTACCTTCT AACACAGACA CTCTCACTAG GTAGGAACAT CGAATTCTAT TCAGTTAGGA CAGTGATGAT GTCTACATAT TATACCTCTG CAGAATATAC AACACAGCAC AGAGTGAATT CTAATGTAGC CTGTGGACAT TAATGAATAA ATATJTGGCCC ATCAGTTGTA ACACTAATAT AAGATGTTAA TAACAGGGGG AATTGAAGGG GATATGTTGG AACTCTTTGT GCTTTCTGCT CAAYITTTTCT GTAAACTTAA AACCGCACAC 3TATTTTAAT TITTTAAAAA GTATTCAGAG GGACTTGACC TTTCCAAAYI' CTCTCAAAGC AGTTAAGAAC ACAAATTTTA GAACCAGACT GCCAGAGTTT GAATCCTGGC TACACCACTT AGATFTTCAGA CAATTTACTT AACTTCTCTG TCTCAFJTTTC TTCATCTGTG TGATAAGAAA GGCCAGGCCC AGTGGCTCAC GCCTGTAATC CCAGCACTTr GAGAGGCCAA GGCGGGTGGA AAGATCAGCC TGGCCAACAT GACGAAAAAA TACAAAATCT CTACTAAAAA TACAAAAAYT GGTGGCAGGC ACCTGTAATC CCAGCTACTC AGGAGGCTGA GGCAGGAGAA TTGCTTGAAC GAGGTTGCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT CTAGGCAACA GAATGAGACT ATTAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAATAT AGTACCAGCC CCTATCTCAG TTAGAAAAAT TCCCAGAATA TAATAAGTGC AATGTAAGGG TCAGCTATCT TCATTATTAT AAATGAAATT ACACAATAAA GCTAGATCCG TTTCTTTCCT CTCCT-FCTAC AAAAAATAAA AGAACAATAC CCAGGTGATG ATTTCTCCCC TGCTCCCTCC CTAAGATATT GGCAAGTT-rG GGAGAAACAG AGCATGTAGA GAAGATACCT CTCTCATAAC CA1TTGTGAT TTACAAGTCT TTTTGAACT AAAGGATGTA AGAAGGCTTT TGGTAGCflC CATCTGATTC AAGGCTITTGG GGAATACATG AGAACACTAG GTAAAGCACT GTCTTCCAAC ATGAAGAGAG AAAAATATGT ATGGCATGCT TTGTATAAGA ATGCAACTTA CCTGGCAGGA ACAAATTTCT TrGCTGCAAA AACAACCATT AATTCAGACT AAATGACTTT TAAGGATATA TTAAATCCAG ATACAATATG TCAAGTGTTG CAAACTCGAT GCTTCAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT TAGGGTAAAA TGCAAAGTGC ACAGCCATCC AAAGGGCATA GCAGCTTCCT AATGCCAGCA GGGTCATCTrf GCCCAAT-rCA GCTCCCAATT 'TTCATGAGA AGTCCAAAGT CTTAATTTAA TCCTATTT11G TAAACGTCAG AAC'rrAACTC AAAAATGTTT TAAGTACTCT TAAACATGTA ACCATGAGTG TAGTCAGATG TGCTTCCATA TTCcT-rATGA GAGACTCTCA AATTTAAGCC ATAAATCTCC T1TAGGAAGAA 'I17TTATCCAT TTTCCTJTAGA GTGCTCATCA TGGCAGTTCC TCCGGGAGGC ATCATATAAT TCAACATGAA TAGCACCCCC TGGAGTTGTA CAATATrAGG

TCAGCTGTCG

YJ7ACAGCGAG

TGGAAGAAAA

AGTCTTI7TCA

TTJTCAGCCAT

GTITAACTTCA

AGAACACTTA

GATAGACCAT

TCAAAACCTA

TAATGTATCA

GTGGTGGGGA

kCAAAAAAAG

AGGTCGGAGT

ACTAGCTTTG

TAAAGTAACA

TCAGGAGTTC

AGCTGGGTGT

GCAGGAGGTG

CCATCTCAAA

AGTTCCTAGC

TATCTATCAT

GCAACTTTCC

GAGGGTTCAA

TACCTGATTC

CAGCTGCTGT

GGAATGTTCA

kLGAAAAGACA

ACTTAATTCA

CTGTGGCATC

AATAGCTACG

ATGTGAGATT

AGCCAAACAA

TGTACTCCAA

ATrGCACAAT

CACGACTAAC

173 ATTTTTATTT CCTGAAACAC TTCCCACACT GAGTTGTACT ACTAACTCTT TTCTTAATAC T-rATACTGCA TTTTATCCAG ATI7CTAAYrA TTGTTTAAAT CAGTAAGCAA GACCATGACT AAAGAAATGT ATTITCAAAA ACATITTJTGA AGTACATTCA TAAACTTCCT CACCTfTCCG CGAAGCCAGA GGAGAAATGG TGCTAATGTC AGGAGGGAGA GTCCAGCAGC AGAAAGTCCA TTCTGC17AA

TATCAATGAG

TAAGCATTTC

GCTACCAAGG

GAATGTTGGA

AGTCTCTCCG

17AATACAAG

TCCACCATTG

AACACTGCAC

CTCTGTCTCC

TCCCCATACA

TGATTACTGT

CACCTTCACA

GAGCGTCCAT

CTCAGTGGGA

TCCTGTCCCT

AAGCAGAGAT

GCAGGCAGAA

TrGCTTGCTC

TTTTCCAGT

ACTTAATATT

AACAAGATAG

GGTAGGTAGC

CCTTCAGGAC

GCTAAGGAAG TAAGAGACGA AGAAAGGTCA TGAGGAAGAA TTGATGTTAA TTGGCCUTTT TTCTGTACAT TCATrACTAG GAGCAGAAGA GCTATCTAGT GTGGCATTAC AGGCC'rITGA CTCTAACTTG CCAAGCTCGT TCTTGCTCTC ACTCCCTCTT TGTCAGAATT CTACCCUTTC CACAACTTGT CAACCTGGGC CTCCCCCTF-T TTCTTTTTAA AGGCCAGACC AGTGTCCTGT

GATCTGCTCC

TCACAATACC

GTTTTCCATT

CATCAACATG

GAAC'TrTCTG

TCACCAGACA

GGCTCCACAT

CCAAACACGG

AAGCCACCTf

ACACCACACC

TCCCCTTTCT

CAACTTCTGT

G1TTrGGATAT

ACCACCATCA

GTCCGAGCTG

GCTCCCCACT

TGAAGCTATT

TTGGTTAATA

CCTCTCCTCT

TTTTTCTCTA

AATGAATAGT

ATCAATGCAT

CAGAGCCATT

GCAGCTCATG

T-rGATCTTTC CCGGAACTGC CAGAAAAATC TACTGGAAAA CYJ7AGITTTTC AGCATGTAGG AGTATTTGAC CTGTACCCTA ATTGTCCCTG AGATGTGCAC ACAAGAGGAC TTGTAGGTGA

AGGCGAACTT

CAGGCTTGAA

CTTCCAAAAC

AAATTAGGAC

AAAAAGTCTG

TCAAGTTGAG

ATTCTCCAAT

AGCTGGAACA

AAGTTCCCAA

GTGGGCTTCT

GCACACAGTG

TGGACAGCAT

ATACGTTTCC

CAAAGACTGT

GGATCCCTTC

GCACTAGGAA

CAAAATGATG

ATTCAAGCAA

TCTITGAATT

TGAGCACTGT

CATATGGGTC

TG~rTTGCAG

CGCATCTCAC

CAAGGTAACC

ACCT-rCACAT

AACACAAAAC

GACAATTCAT

GTCAGAAAAT

CACTTGGAGA

TCAGCCCCCT

TCTTCTAACA

ATGGATGT17 TTTGGT-rTTT

CCTGCTCACA

GTAGCCTCGC

ATTGCAGTGG

ACTGAAGATT

CACTGATCAT

CACAAAATAA

ATAGATGGTG

GTGTT1ATGTT

AAAACTGCTT

CAATACTATC

CATTTTACCA CTGCAAATGT TAGGTACACA GGCAGAGTTT TTGCTTAAAA GTCAACAATG AATGTAAAGT GTAAGCGCTA CAAACCCCTT TGGGGCAATC TAGGTTCAGA AACTTrATGA CACTCAATTC TACCTTGGCA GGAAGGAACC TCTTCTGTCC TTGATCCATG TAAITCAAAT CCCTCCTCAC AGCTGAAGGC AGGGGAATGA GCACACCTCA CCAAACCC11T CGGGGGCTGG CAGGAGAGAG CACT7TAGAA GTTTGTTTGC ATCTCCAGCA GCTCTTCAAT AGTFCTTTTT ATCTI'AAAAT AAAATAAAAA CGTTGTCCCA CTCCCCTGTG GGGCCACA'rr GGAGCCTTTr GGAGAACTCA CAGCTGGACC CATAACGGAA ACTGCCAGAA TCGGGGTTGG ACAAGGCTGT GCACTGGAAA GCTGAGACAT AACTAGAGAG TACTTGGCGT TTGTTGAGTG AACCCAGTTC CTTTATAATT CCCTGGACAA ATGGGAAGAT GGCTGTGTTT GGCACTAATT AAAAGACTAA TTAATCAGAA CATTAGTTCC A'FrATGGTCC AAGGAAAGAT TTCACGCAGT CTGAGGACAA CCAAAAAGAA AGAAAAGAAA GCACCCCTAT AAAATTTGTC TTGCTACTGG AAATCATTCT GTGCTGGCTr TGGCTAGGAC GYTT-CAATA TCCTTGCTCT CACTYJ7AAAG TGAATTAAAA TCTGTAGCTG ACACCATGCT TGAAACAGTC TCATCACTGC AAGGCCAGTG CCTGATAGTA

TTTACTGCT

TAATTATGAG

CT-FTCCGAAT

T-TTTATCAGC

GGCCAAACAT

TTAAAGTGGG

TCGAAGGATC

ACCTGGGCTG

CTCCAGCAGG

TGTAACAAAT

GAAAGAATGT

ATTCCCAGAT

CAGG'I1TGTGT

CAGCATCACA

TCCTATTGAG

AATTCTTAGG

ATATATGCAT

CCATTTCAGA

TTTCTAATAT

ACATCACAGT

TAGTTCTTTT

TATTGGTTTT

TCAAGCI17AC

GTCCCTGCAA

GGAATGGCTG

ATACGCAYI7G

TCACAGTAAG

GAGGTACACT

TCCATGGGAA

CTCAACCACT

CTGGGTGCCT

GACATGCACA

AGACAGGTGT GATGAGAGTT TTACATTCAA ATCATG'FrCT CATTA17CTG GATTCCTTTA GATTAAGAAT TCTGTCTATr CCATGCTAAT GTCTACAAAG TAAAAAAAAA CAGCAAAGAA TTCATTC'rrA ACACATATGA TCCTT-rCCCT AAATGAATCT CAAAGATACG AGGGTTGCTC ATCAAATCTG AYFTCTATAG T'FrTT-rCACT GTCCAAGT-rT GAAGATGGTT GTTCTrTAAG AAAGTATAAA CTTCACAAAC TGGGATTTGC TGTGTCCACT GCCCYJ7GAGT GGTGCATTCA CATGAAGCCT TCCTCACAGG TGAAGTTGCA GGATGATTrG AAGGTGAACT CACCTCACAG AGCCATTCTG AGGCTGGCGG ACGGCCCTGC ATGTCACAGC ATATTAGCAC GGCCTAGAAT TAGCTTGCCC ATCCAGTA TGGGTTGAGA TCTCCATGTG GAACAACTCT ACCTTTACAC GTTGGCTTCT CGTTGTCCCA GAAGGCTCTG GGCTCCCATT AGT[CAAATC CT-FCTTCACA GTCAAATGTA GCTTCCAGGG TTTTGGAAAC ATrrCCACGAA CCCATTGGCT GGATT-rGTCA GAGGATTTrA AAGAGCACCA TGAATTUTAC AGAAGAATGA TCTTTfCACT AACAGAGTGA GGAAGCTGCC T[CAAAGGGT AGATCCCAAA GTCCTATGTC GCCAGAATAA AAGCT1TrAT TCITrTTTCAT GGATATTCTA TCIYI17CTGA TITCCACTTT GCCTATGCTG AGTGGTCTCT AATCTATGTT ATCATTTACG TGAGGTAAAA ATTTAAAAAA AATAGATITCC AGATrAGGAG GAGCCTGAAG AACTGATTrrT ATACTAAGAC TGCTITGACTA AGATGAGAAA TCCATTGAGA CAGAAACACC CATrTCAAGC TACATTGGCT GAGAGAACAA ATGTAAGTTG AATCAAAAAA ATUFACCATT GCAGGCTGGA GCTTGGCAGG TAACCCCTAT CTGCAAACCA GGCTTCCATG TCAGTTCTGC TCATCTCTCA TTT[AGT TTAAAAATTT CTMATTCA AGAAAATGCT AATATTGAGT GATATGGGGA CACAGCAAAC TTAGGTACCA GCTTCCAACC AGGATGAGAA TAAAACCC TAATGCTGCA AATTCGTTGA AATCAAATAA TI7ATGACTAG TACTGACATA CGTAGGCTAT TCATTTATTT TCTTTTTG GCCTCTGGTT CAGAAAGATA AAATTAAGAG TCATGGTCTT AAGTTAGTCC CATGGCTTGG AAAAGTTAAA

TAGCCCATCA

AGAAAAAGAG

CAGGGAAACA

1TFCTAGAGC

ATAGAATAAA

ATTGTATTAA

CAGAAGCAAT

ATAGGAGCAC

CACAGCTGAT

CTCAGGGGAT

CCTITAACAG

ATAAAATTTC

TrATTGTTr TATGGTCTCC CTI7ACAAATC ACCAGAGCCT AAAACCTCTC TCAACCCAAG CAGGTACTGG GTTrGGCAATA AAACAAAAAC AAAAAAAAAA CTTTCCCTGA AGTTFrTGAAA GAGGGATGAG TTACAGAACG TTCTGTGCAT TCTCAGAGGG TCCATTCTCC AGAGGACATA CACTGCATGG TCTCCATGCT AGAGCAGGAA GAATTGTAGC TGAAGTTFCC CAGTGGGTGA

TCCAGGGCTG

ATAAGAACAC

TAATGGAATT

GATCCATAAC AACAACAACA GAGTAGTGTA ATTGTGTTrA CAACAAATT17 CTTGTTACTT CCATrCACAA AGCTATATTT CTGTCTACTA TAGTAGCCAC CATTTAAAAT TCAGTTCCTC TACAGTTCAC AACTGAAAAA GAAACCCAAA TGGAAACTAG AACTACAGTT TGGT1TrT TGTAAAATTG ACTGTAATTC TACCCCTrr AAAAAGCAGT GATGACAACC ATAAAAAAGA CCTCAAAACT GT1TCAAATTA TATGAACAAA TTFCTCACAAC TGCTAAAAAT ACTACAGTAA CAAATTTAAG TACTAGAATA CATTACAAAT TATCTGTGTG GCTACTCAAA TTTAAACTTG AGTGTCACCA GCCACA1TrTC AAGTACTCAA 174 TAACCACATG TGGCTCATAG GTACACACTG CTACTGCACA ACGCTGTGCT AAGGAATCTT GAACTGAGAC CTCATTrCAT TCAAGTGACT CAGAGCATGA ACCAAGATAC CCTGGACTCT AGATGAGGTG AGTACATGTT CCTCGCAGGG GCACCATGTA ACCATGAGCC TATGAAGTTC TAGAGAGTTA AACTATCTTG TCAAGGTGCC GGTCTGACTf CATAGTCTCA GCTCACGATC AGACCTGACT CTAATGCCAG CTAGGACGTG CAGACTTACT TTGCTCACAC TYfGAGTCCAC CTCTACACAT TCACCGTGGC CACTOCAGGA GAGGAGGACT ATTACTGTGC TfATACTGAG CAGCAGTCCT ACAGAGTGCC ATAGAC'ITTA CCACCTATCC TAAACCTTGA TGCTAATGTA ACAAACTCTG AAGACAGTT1C CCCTACCACA TTTATATGTA AAGAACTACA TATTTGCCTA TATGTGTGTA TATGTGTGTA TGTATATATA ACACACATAT ATGTGTGTGT GTATATATGT ACATTCACAC AAAACAGCAA AAGAGAGAAA CACAATAGAG AGCAGTTT-TT GCATGCTGTA GCTGCCGCAA ACTCCCTACC TGTGTAGCAT TGCCCACATC TrTM1CTCTC TTGATGTAGA ACCTGGAGCC CAGTTCTTGG CTTCTTCTGT ACTTTTCTGA TTCCAATCCA GTAATAACTT CTUTGFITTTG AATTGCAACC AGGTGTGTGT AGCTTCCGTG GAGGTGTTGT AAGACCAGGC GAAAACACAG CTATGGAACA TTTCCAUrAT GGAGAGAAGC TCATCTAACT CTCTrAATGT TGCTCCATGC TACACGGCTA GTCATTACAG GTAACTCACT CATrTCTACT GCAACGTCTT

CACAAAAGCT

ACAAATTTAG

AGCCAGAGGC

GTTACCACCT

ACACAGAATT ACAGTTTATT GAATGTGTCC TGTGTGCCAG ACACTATTAT TATCCTCATT TTACAATGAG AAAATAAATA ACTGGTGAAT CTAGGACTCA ACCATATGAC ACCATCTGCA CCAGGGAAGG AGATGGTGCT ACCATCTCAA GTGAAGAAAG TGAAGCCAGG GTCACACTTG CAAGTGTAAT TGTATTGGTA CAGGCAGCTA CGGAAAATAC TGCCTTTGAT TTTAGAATCA ACAGTGTGCA ACTGAAGTGT TTI'ACAAAGT TAGCTGTGGC TGGCACCTAC AATAAACAAG TAATTAAAAT

CAGTATTTAT

TAAAATGTAT

GTGTGTGTGT

CTTTAGCAGT

AATTTGCCAA

AGGGCAAGCT

TCTCCACGCA

CAGAGGTTTC

GGTGAATAGC

ACCTTTGCTG

ATATAT1TA

ATAAATGCTG

ATATATATAC

TAAACAGAAT

GATGCCCACA

TCTrCTTGCT

GTCCTCATCT

TGGGTTCCTA

TCAATATGGA

ACAATAAGCA

TCCAAATCTG

CGTAGAAAAT

ATGTATJTGTG

TATATATACA

TAGGCTATAT

ATATCCACAT

CTT'FrGGAAC

CACTGAAACT

GCACCTCTCA

=ITGCCTAT

CCCAGACCCA

GTTTAGGTAC

CTGGCCTCAT

AAAACTGACA

AACCCAGCAG

GAAGGCATGC

AGGCAAGAAC

TATTGATGGT

AAAGCATGAT

ACAGAGACAT

AGYI'TCAGGC

TTACTTCTTC

TGTGTGCATT

TACACACATA

ATATATACAC

ATTCTUGCCC

ATAAAATGAC

ACCTCCCACT

TCATTCCACA

TGTTGGGTTC

CACATTGTTG

TCAATCTCTT

CATAAGTCAT

TCCACTCTCT TTAATGAGAA GCACTAGTGG GAGAAAAAGA AAAGAAATGG TAGAGTTTGG TACTGTTGTG GTTTAACTCT GACAACTGTG CTTUTTATTG TC17ATrTTTT GGCAATGTT GTGACATGGC CCAGACTTT[ CTCATCTT= CAAAAGTAAG AAGTACGTAT GAAGAAACAG CGACTTAYJ7G YT7ATCTCTr I1'GTGACTGC CACCCACTAG GTACCTTATC CACACTCACT CACAACATTA TAGTATACCC ATrTTGTAGT AGAATAATAA TCAGAATAAC TAAGCTTTAT TGAGCACTTA GTATGCACCA AGAAGCACTG TATGAGGTAC TfTCCATGAA CCATGCTATT GAATCCTCAC AATGCATCTG GGAAATAGGT CATrTATGATC CACACTrTAC ACTTAAGGAA AGGGAGACAC CAAGAGGTAA AGTAAATGAC CCCAAGCCCA GGGAAGAACA CA'rrGCAGGT AGAGGTCAAG GATGCTGCCA GATATCCTGT GCAGGACAGC CCCAGACAAG

CAAGGATATT

CCAAAGTGAG

GCTTGAAATA

CATTATTCTA

TATTrTCAGAG

AGGTTTTAGC

TGTTTCATGG

ACAGGATCTC

AGCCAAGAAC

GGAGGATATT

ACGATGCTTA

TATATCGTAT

TGTCTT[AAA

TrCAGAAACA

GCTGTGGATA

ACTGTCTCAC

ATTAAAATAT

AAAATGGGAA

CCAGGCACAG

GGGAGTfCAA TCAGTCTGAA ATATCTATAG TGCGAGAATG AGAAATCTrG GTCTAATGGC ACTGACTTAC AGCTGAGAGA AACTGTGAAG CAATCATGAC TTCAAGAGTT CTTTTCACCC AAAGGTTTAG CTTTCCTGGG GAGATAAAAC CCATGATGTT TAAGGCAGCA TTTAATCAAA TAAATAAACA TACAATACAA TAAGAGCTTG CCCGAGGCTG CCCTTATAAA TCAGGTGGGT ATCACTGCTG AGCTGAACAC TAC17CGGCT GTCCACATCC AGTAAAGAGG AAATI7ACAAT GATGTCAGAA ATGCAATYI7T A'ITAATATGA

ACAAAATGAA

TCCTAAGATT

AATTTTFAAGA

TACAGATGTG

GCGTTFCTGCA

CCTCTGTCTC

GAGGCCC1TI7

AAATCCCCAA

ACTCTGTCTC

CAAAAATGCA

TrAGTAGTGT TTAAAGAAGG AAATCGTGGG TAGCTAGTTA TTGGGCAAAG GACACTAGTG CAATAATCTT CT-rTCATTAT TI7AGGTCAAA GAGAAAAGAC GTTTTTATTA GAAGGCCYFT TGCATATCTG CTTACCGT1T TGGGAAGCAG T-rGTTCAAAC AGGTCAGTAT AGGAGTTrG ATGTGAAGTC TATAGGAGGG ATTGCTTCCT GTGAATAATA TGGCATCCAA AAACYI7TCCC GGGAATATCC T"rGAAGCTAC TTCACCTFrTG TCCATGCCTT TGATTT11TAA TTATAATAAC ATAAAGTCTA CTCTCATGTA GTJTGTGGTAG TAATJTAGAAT AAGTTGTAAA

GAAGGAAACC

ACCAATCACT

AGAGGAATGA

TATCTAAAAA

ATAGATATTT

TGGCTCACGC

GACCAGCCTG

AC1TTGCTTG AAGAATAGGT TTFGTCATCCA TAGTCTACTA CCTTCAATTT CTCAI1TCATA ACTCATIT TCTTCCTT TCAGCTGCCA ATTCAACATA TTTAACATGC CTCACAAGGT AGATATTAAT CT[CAGAT[ TGCACGGCAG TITATGCCTAA TAATATCTAA CACTCAAATG GTTAAAATAA TGCCTFTATTT TAAAAAAAGA ACATCTGGGA AAGTFTCATG GT'TrGTTCAG TGAAAAAAAT AAAAAGGAGG CTGTAATCCC ACCACT17TGG GAGGCCGAGG CAGGCGGATC ACCTGAGGCC ACCAACATGG AGAAACGCCA TCTCTACTAA AAATACAAAA TTAGCTGGGC ATGGTGGCGC ATGCCTGTAA TCCCAGCTAC TCGGGAGGCT GAGGCAGGAG AATCGCTFTGA ACCCGGGAAG TGGAGGTTGC AGTGAGCCAA GATCACGCCA GTGCACTCCA GCCTGGGAAA CGAGTGAAAC TCTGTCT-rAA AAAAAAAAAA AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT ATATATATAT ATTTrAATTGG TCAAAATT GTTTrAAAATT TTTrGAAATGT TAATGTGCAA AGAATAAAAA TTCUTCCACA ATGTTAACAG TGACTAACTC TGGATGGCAG GATTTGGGAT AATTTATA TCCTCATTA TTATTITTCAG GATTTTAAAG TTTrrTCAA TTTrCCCTITT YIFTCACCTTT ATAGTAACAA GAATACAGT~r TAAAGAAACT TGTCTCTAGG CCAGGCATGA TGGCTCATGC CTGTAATCCC AGCACTGG GAGGCTGAGG TGGGTGGATC ACCTGAGGTC AGGAGTTCCA GACCAGCGTG GCCAATATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ATTAGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGGAGC CTGATGCAAG AGAATCGCTTF GAACCCAGGA GGCAGAGGTr GCAGTGAGCT GAAATCACAC CATTGCACTC CAGCCTGGGC GACAGAGCAA GACTCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAAAG AAAAGAAATT TGTTTCCAAA TGCAACAGAA GGAGATGTAT GTGGTATCCT ATATTCCTGC TCTrCA'FrTT GACAT'rrCTr CTGGGTGATT GTATACATTC CCCATCTCTG CATCTTACCC TATCTAAATG ATGGTAACAG TAAATGGGGA TCATTTTAAT TCCATA117C TGTAGGTTYT CAGAGCTCAA GTCAAGCTAA TATTCTATAT CTACAGCCTT TCAAAATAGG AGGTCTATCT AAAAATGTAC 175 TGTCAGCAGA CCTGAACGAG TAGTGGTAAA AGCCTCGUTT TTCTCTTTAC GTGT[CATAA AGATGTCAAG ACCCAAAAAA AAAACAAGAA AAGAGAAGAA GATTAGAAAA AAATAACTTA ATTAACGAAT CCACCTfACC ACTCTCTTAC ATGATCCAGA TCAATGTGGT TGTTGCTTCA ATAAATTCAG CAGAATGTCA AGTTGGG'FrA ATACA17ATC TGCTATTTT AAAAAGCATG GTCAAATGTA CAATAAAGTA CCTAATAATT ATATTGCTAA TATTGCGAAT TTTTCATAAC TAAGTTTATA TAAAAATAGC CCCAGTGGTG ATGAAGTTTC ATCTCTAACA TITATTGAGT GCTTACTATG GATTATTCAA TCCGTACAAC AGCCTATGAA TGAGAATCTG GGGATTTTAT CTCAYUCAAA GAGCCCACTC CCUTACCTGC TACTCCAAAC TACCCAAGTT TCCTGTACTC TTCTITGCCCT GAGATAACTG TGTCCTGGGT TCTGAGACAT GAGGATOCAG TGAGAACAGA CCCTGGATCC AAGCAAGGGA GGTGGAGCCA TGCCTAGGTA CAAAAGCAAA TTTTCTCTAA GGTCAAAGGG TTGAGAAAGC 11TCAGGGAGA GATCCCAATA AGTAACAGTA ACTTAAATGT AGACTATATA TATATTATAT ATGTGGAATA TATATATTAT TATTTTATAT ATAAATATAG ATATITTTAT ATAAATATAT GTAAAATACT GTGAAAGAAG AAGTTAAGCT TGGGAAATGA GTCATGCAAA TGCTTACTTT ATCTTATATA AAATGTAGAT CYF7CTTrFA CATGTAAAGT GTAGACTCAC CATTGCCAAC CCATCTTTCG TT7ATTTTCT CCCAAAACTC TCTTTGGAAA AAGCGCAGGT AAAATAAACC TCTAATCTGT TGAGATATGC ATAAT~rATA TGTATATAAT ATATGTACTT TACAATTACC TGCATTCTCC CACAGTATTT ACATGGATAC TGGGAGCTGA TGGGCTCCCC AGCTTTCCTC TCGTGGAGAG GCCCTGGGCC CYI7CACCTGC T1TFrcCTAT CAGGATTTCA AGGGGGAGTT GAAGAGGAAA T-rGGGTAAGA CCCTCT-rCAA ATAATCCAAA ATATACCCCC ATCTCCCAAG CTCTGAAGAT GTAGCTAGCT CCCTCT-rGGC AGTITTCTCGC ATGGGGGAAG GGTGCAAACT CAGGCACACC CCGGTGTCTG GCTTTATfGT CTCTTCCTGG AAGTCTCTTG AACCAGTTT-r GCTGTGTGCC CAGGCCCACT ATAGCCAGAA AGAAGAGATT GGGGACCCCA AGGAGATTAT TGGGTrTAGT GGAAAGCAGC GTGAAGTTAT ATITTGGTGAA TGTGACCGGG CTGTFCCCTF ACCTCTGCGA AGGCTfATTT CTCCCATAAA AAAGCTCTAC TCTGCTAACA TCCCAATAAA GATTCCACCC TATCTGCAAA GAAAATGTGT ATCACCACAG TAGAGAATGG ATGTGTCTGG TTCTAAGTTr AYT-cCCAGA ATATCTGAGT CGAGTAGGAG CTCCGGGCTC GTT1CTCAGAC FTAGAATAA AGAGGAATCA

TTAATTCAAC

TACTGACATT

AAGAGTAATC

TGTATGTATT

TAGAGTAGCC

TAGAAATTAG

GTTTATCTCT

TATTT[ACTT

TGCCAGGCCA

ATAGGTACTC

AGCACAGAGC

CATGATTTCT

CTJTCTTCCTG

jGGGGCTGGA

CCCTATCAAA

ATTCCAAT-C

ACTCATATAG

TTA17TTAA

AAATCTTAAA

TCGTTAACAT

TCCCCT-TTT

ACATATATAT

TATTCTGAGC

CTATTATCCC

TAAGGGTTGA

T17rGTT~A AGACATCC17 TTGTTAGCAC TGGTCTTTCT AAATTCCAAA AAAGACAACT AAGCATAGAA 1T-AT-rCCCT TTT1ATCCCAC TTTAC17AGC TGTTTAT-rTA GATTTTAGGG TAAAGTATGA ATACATAATC AAACAATTTA TCTTrCGATAT CCCTAGATAA CTAACTTTAT AAAATTAGTT CAAAGATATC GTCCTGGACC CCCAATrATA ATTTTGTATG 11TCACCTATT CATTTTACAG ATGAGGAAAT AACCAGGCAG TTGATATCCA TGCCCCGAGA TTCCTTGTTC GACCATCACA GCTCTCCACT AGGGACCCCA GGGACAGTGA GCAGTAGGGA CCGGTGCATA GGCAGGGAGA AAGTGGACAA AGGAAAAAAC

AAGTTGATCC

CAAACTGATT

TTCGAAGGAT

TAATATATAA

TTATATATAT

AT1TTATATA

AATAGAATCT

AACTGCCTTC

GTACTGAGCA

TGAGTGTTAC

TCCCCTCCTG

CACAGATCCT

TTCAGTTACT

GTIT[AACCA

TCTGTGTCCC

TCTGGCTACC

AGCGCTGCGT

TAAGAGGCAA

CTAAGCCACA GTTCCCAGAA GTTCCTGATT ATTCTAAATT CTAAACTGAT TATTTCTAAA AAGAGAAATG AGGAGTGGAA GAGATAGGTG TATATGTAGA GTATATATAT ATAATTACAA TTATATATTT TATATATATA GATATiTTTA TAAATATAGA TATiTTTTATA TATAilTATAT TGAGACCTCA AATTCACTAT GCCAAAGGGA C1TIGTTCC CAAATACCTG TAATTTCACA TGAGATCCAT GCATAATTTC CCTCTAGTCC AGAGCCTTGC CACAATGTAA ACACTTGTCT CT-fGCTCTTT CCCCTCTAAA GATGGAAGTT ACAGTGATTT GTGTTTCTTT TACCTGGGAC TT1TGGTTTA CAATATGTAC ATGTATGTAT GAGGTATGTT ATTCAAAATC CATTCATCCT TGCCCCCGAG GTTGTCACTG CAAATCAGGT TGGGCTGCTG AAGGGGCCAT AGACAGACCC GGGAGTGGGA TTACAACCAG ACTATAGCTT T'TGCTTGTTT TTTGAGGGTG GGGGCAAATC TTTGAATAGT TGGGCATGTT GAATATTATG AATATCATCT AAGAAACAGG CTGATTAGAG GTGCTTCAAG GCTCCACTGA GTTACCGGAT TGCCGGTTI-T CAAGCCTCGC CTCACATGGA CATCCGCTAC ATAGATGGGA ATGAAAAGAG GAAAGAAGAC CCACCAGTGC TAHTTAATCT CTGAGGTGTC ACCCTTCCTG TCCTCTCCTC CACACCCYIT AATCAGGCAT CAAAGACTTT CATrCTCACT 'T7TATGGCAA AGGGAGTGGG AGACAGAGAG AGACAAATGT TAGAATTA ACTGGCCACA ACCACACGTG AAGCAGGGGC AGTGGTGTCC TACCCCTGAG TGCTrAGTTT TCTAAGTTAC CTTTGCAGAG ACCAAGGCCA CCCTGTGGAC GCAAAAGCAT CTATCGAGGA TCCTGCCTTC CTGAGGCACT TGAAAGCCTT AGTTFCCCTCT TCTTAGGTAG AGGGAGGAAA GCATTCCCAA AATTGTGAAA CCTAAATATA 'TTTGATGAAA GAA1TTATAG ACATCTTATA

ATACAAACAT

CATTTMTGT

AAGCCATGTT

GGTATTTCTT

TTGATCAAAA

TACTCACTTG

TACCTCACTC TTTTCTCCCA CACCCAGGGG GAAGTGTAGG CCTGGACAAC TCACCTAAAA TGCACATCTT CAGGTCTCAT ACTCAGAGGC TCTGACTCAA CAGGTCTGGG TGGCGCCCAA GAATTTGGGC TTTAAATGAG TATCTCAGAT GATTCTAATA CAGAATGTGT AAGATGACCA GATCCTATCA CACTTAGATG TA'ITGGCCTA GGGCCACCTA ACTTGGAGAA AATGTTAGTA AGACCCCGTG GTTGGTGCTC AGCTATAGGT ACCAGAATTT TGATCAAAAT I1TACTATCAT TGTGACACTT CTCTTrCGGAA CTGGAAGGCC AGAACCCCAC rFGTAAAGTG CTGGGAAAAT ACAAGGAAAA TTTAGGGTGA GTAGCATr GAATTCTTAC ACATGGAAAG TAAATGTATA AGAATTCTTA CCAATAAAAA AAAAGCAAGA GAGAATAGCT GCTAAAGAAT TAACACAAAT ATGTATATAT TAGTTATTCT CTT7CTCCT CTGATTCCAG AGGACTTTGT AATrCCACTA ATTCTTCTTG AGCTTCCAGG ATGATCTGAG ACTITGAATTT TTCATGTGCT 'rTrTGCTrrCC TATTTGGCAG CATCTrATCT TGAAGYI17CC GCTTfCTGCT TGGGGACCTA AAAACTAACT AATGGGAATT TCTTCAAAAT GAGCAAACTC TGGTGAATTrC CCAAAGCGGA AGAAACAAGT GAGGATCGGG TGT-rGT-rAAC ATGAGGGAAG TGTGCTGCTT GTTTGTAAG CT7CTGCTCT GGCCACTTr CTGGTTrAATT

AAATACCCCT

TCAGAAATTT

kAACATATAA AAGAGAACTT TTCCTGAATG TAGCCAGACT GGATrTTAGA AGAGCCCCT-r GTTTGTTJ7C CCTGAAGGAC TA17ATTAGC TTI'GTTCTCA CTTGGATTF ACTGTATTAG AAAATGTAAC

GTTTGCCGAC

CTFGGCCATT

CGTCAGAAAA

AATTACAGAC

AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC 1TTTFCT TCCCCAAATC TAAAATAGGT GATMOGAG AAGTAGGAGA AAAACCTGGA T-TTCTAGAT CTCITfTAGAG CTCAACAACT GATATAGTTA 176 ATTATGTAAG TCTTTGATAT TTGGAAATGA TTGGATTAAC CGGATAACAA T-rTGGCCAGG AGCAGTGGCT CATGGCTGTA ATCCCAGCAT TTGGGGAGGC AGGCCGGGAG TTCCAGACCA GCCTGGCCAA CATGGTGAAA CCCCATCTCT CAGGCGTGGT GGTGCAAGAC TGTAATCCCA GCAACTCGGG AGGCTGAGGC GGAGGCAGAG GTTGCAGTGA GCCAAGATCA CGCCAITTGCA CTCCAGCCTG

ATCTCAATAA

GTCACTGGGG

GTGCTTTACT

AT17ATATCA

ATAUTTAGAG

GAAAGGTAGA

TGT~TTfCA

YJTGGCTCCAT

TACAGCAGCC

T-rTAGAAGCA ATAAATAAAT AAATACAGTG ATTTAACACA CAAGCTTCTT TGCCTCATTA AGTCTCAGAT ACCGTCTCTG CTAGCTGTGA CATAATATGA(

AGAGATTTCT

TTCCCGAGAG

CAAAAGGTAT

TGAATATTTA

TGAGGCGGGT

ACTAAAAATA

AGGAGAATTG

GGCAACAAGA

ATYTCACACT

CTFATTTATT

AAATATGGGA

ATAATTCATA

TCTTACAAAT

GAGGTTACAT

TAAAGTCCGT

GiTTACAT AGTGCCTfrAG

AAGATGATCC

AATACAGTGA

GGATCACCTA

CAAAATTAGC

CTTGAACCCG

GCGAAATTCC

AATGAGCTCT

TATACCAAGA

AAAGGCACTA

AGAATATACC

TTTACAAAGT

AACT-FGCCAG

GTCCT-=fA

GAGAAAATGT

ATCGGGTTCC

CAAGAAAGCC

AAGCGTTCTT

TGTTTACTAT

TATTAATCTC

GTTAATAAAT

GCCTACTCAG

TTCTCGGCTT

GACCTCGAAA

CGTTTTTCCT TGCTGTGAAG TTrrrAGCTA GCATGGGCCT GGCAC11TCAC ATACATTGCT ATTTTATGGA GGACAAGATA GAGATCTGGA GGTAGGGTGG AGATTCAATC TGTGTTACTC AT11TAAATCT CAGCAGGGAA GTAAACCTTA CC'FrTACCCC CATCCCAGTT TCACGAGCTT TAAGGATGTG GGTGCCAGTC ATYJTATTGAA TAGTAGGAGA GTGAGGAAGT GAGATGGGGA AAGGAAGAAA ACCGCTGTGG GCAGCCATGG GGCTCAGCTG CACTAACAAA CTCCACAAGA AGTGTGTTAA TAAGCAGGTT

CTCTGTCTAG

GCCAACTCAG CCCCAAGGAG

CTGGGAGGGC

GAATTCCAGA

GTTTrTCTGTC TAGTTrTGTGT

TCAAGGTGTC

TGTrGGCAGA

AGTCATTCTT

AGCGGCTAOT

ATGTCTGCCT

TATTTTAAGG

CCATTTTCAT

TrTACAGTTC

ACATAGATGG

ATAATACYTA

GGTCCCTCCC

CCTAGATTCA

TGCCCACCAA

TCATGAGGTC

AGCCAGGTAT

GGGCAAGAAG TCTGCCTAGG GTATATATCC ATGGTTAATT CCTCTGCACT YI7CAAGTGGA 1TCCTGTGGT TGCTTGTATT TAAATCTGAC ATGATCTGAA TGCTGTGTTG ATTACTGTAA CAGATTACTA CAAACCTGAT GGCTGCAAAC GGGTCAGAAG TACAGGTTAG CTCAACTAGT TTCTCTGCTC ATCCAGTTGG GCTCYTFCTTG GGAGGCTTGG GGATGAATCC ATCCAGTTCC YTGTGGYITGC AGGACCAAGG TCCCTGTTGC AGCTTCTAGA GACTACCTGT ACTCTCTGAC TCGTGTCTCC CGAGTCCCTC TCTITCAAATG TCTCCAACTG TGCCTTCACC CTACTGCTTG TAAGGGCTCA TGGGATTACA Y-FGGATTTAT CTAGCTGACT AGTGATCTTA ATTCCATCTA CAAAGTCCCT GCTACTGATA AAGACATACC CAAGACTGGG CAATTCACAA CACATGGCTG GGGAAGCCTC ACAATCATGG CAGAAGTCAA CAGCAGGCAA AGAGAGAGAG CTTGTGCAGG GAACTCCTCT TTCACTATCA CAAGAACAGC ATGGGAAAGT CTrGCCCCCA ACAACATGCA GGAATTCAAG ATGAGATTTG TGTGGGGACA TGTTTIGATTA AACAACCAGG GAGCAGAAAT CTTCAGGAGT GGCTGGGCGC GGTGGCTCAC ACCTGTAATC CCAGCACTTT AAGAGATCGA GACCACCCTG GCCATGGTGA AACCCCAYI7T GGTGGTGGGC ACCTGTAGTC CCAGCTACTC AGGAGGCTGA

TACAGAAAAC

TCACTGGCTG

CAGAAAAAGC

GGACAGGGTG

AACACATAYT

TAGG'TFCAC

ACTT-FCAAGC

CTTGCTGGCT

ACTTCACCT[

CTCAGGGTCT

AGAGCTGATC

CCTCTACAAT

GGCGT-rATTA

TA'ITATGTCA

ATTGCCAATA

TCATTCAGAT

GTTGGCCAGG

TCAAACCAGC

TCATTTCTCC TCTGTGTACC TCAATCCAGG ATAATCTCCA TCCAATAGTA CTGTATfAGT AAGAAAGAGG TTTAATTAGA GGAAGAGCAA GTCATGTCTT TTAAAACC ATCAGATCTC TGATTCAATT ACTCCCACCA CAGCCAAACC ATATCAAGTA GGGGGGCATC TI17AGAATTC

GGGAGGCCAA

CTACTAAAAA

GGTAGGAGAA

GGTGGGTGGA

TACAAAAATT

TCACTTGAAC

GAGCAAGACT CCAGGAAGCG GAGGTTGCAG TGAGCCAAGA TFFGCGCCGCT GCACTCCAGC CTGGGAGACA GTCTCAAAAA AAAAGAATTC TGCCCATCAT AATGGCTAAC CTAAATTAGC ACTGTGATGT GGAACTAATC CATGAATGCA AGGGTTTGTC ATAITATGGG TGCCTCATCC ATGTCCCCTr TATATCTCAC TTGTTCCTAT ACTCTGTGAA T-fGAACAATA ATTACGATTA 'rTAATCTAGC TAGGACTTAA GAATACCATG TCA11TTGATC T[ACAAAGAA GGCACTGAGG GTI7AGAGTTT ACTAGGACTC AAATACAGGT CCATCTGACT AAGTGACCTG TGGTTTTACT ACTATATTCA GGAGGOCACA CACAGCACAG AAAACACATG T-rCTAATACC TGATGTTTGC TCTAATCCAG AGAAATGGGG ATAAT[FTTGG AAGTCATAAT AGTAGGCTGT CCTACAGAGA GTTrTCTGAC TTFGGTCCTTA TAGAGTTTTA AGTGGGAGTT GGCATTTATC TTFTCTTGGAT CTGATGTCCC ATAAATAGAC AGTTATCATT AATTGGCCAC ATCATAATAT GGTCAGGAAT AAATAACT1'G CTTAAGATGT CCAAAGTCTA TG'FrCTTGGC CACTCTACTA ACTTlACCAT CATAACCCAG GAAITAGGTG TAGCTCCTCT GCYTAGATGT AAATATCCAA AGTACAGGAG AACCCAACTC TATFTAG'TTTT AT'FrCATf GCCAGTCTTC TJTCACATTAG ACACAGCACT TAAGTATTGC TATCCAAATT CATAGCCTGT AAGTGACAAA TACCACACTG CCTCTCCTAC CTCCCATGAG TCTGTCTAGA AATGCAAAAT AAGGAAGGGC CTACTTACTA TTTTACTATT AATTAGTTGC TGGTGCCCAA GATGCCT17CT TCTCATAGGG TATTAT TAAATGATCA AAAATACCTG TTGAATGAAT GTCCTAATCG TGGATCAG GATAGTAAGC

CACAGAGCCA

GTTTTTACTG

GTTGT[GTAT

AAATGYGAGTC

ATCCTAAAAG

CTCCAGGCCC

ACCTGAAACA

GAAAGCATGC

CTGCCAGCCG

GGCCATGCCT

TGAGGGATAC

TATGTGTAAA

GCTCTGTCTC

GTGATTCTCC

TGTATTTTrA

CTGCCCGCCT

TGATAGCAYI7

CTAATACTAG

GGCCACCTAG

GGCATGGCCT

TCAAGGTAGT

CAACACAGCC

TGTTFAAACAT

ACACTGTTCT

CTGTGTCTCC

CTAACCTCAT

ATTTCCACAG

GGTAGTAGGT

CCAGCCTGGA

TGCCTCAGCC

GCAGAGATGC

CTGCCTCCCA

TACAAACCCT

GAGG'ITATAA

AAGGAAGACT

GTATGAGTGG

CAGCTGCATC

TGGCTMTAG

'rrGTTCATGT TGCTACATTA ATICTCACA ATATAAAAAA AGAAAAGCAT CTGAAAAAAG TAATATCAAA CTGAGCACAG ATATGGAGAA GCTAAGGGAG AGGGATGATG CATGGCAAAA GTCCTGGGGG TCAGACCCGA GGAGAGCAGG AAGTGTCYT TGGAAATAAT GAGACTTAAA TAAATAT7AT ATACACAGTT CAACTGTTTT UTTCACAGTA AGGAAGCACT TC1TTTTTTT TTTGT'rrGAG ACAGAGTCTC GTACAGTGGT GCTATCTCGG CTCACTGCAA TCTCTGCCTC CTGGATTCAA TCCCGAGTAG CTGGGACAAC AGGTGTGTGC CA1TACACCT GGCTAATT GGTTTCACCA TGTTGGCCAG GCTGATCTCG AACTCCTGAC CTCAGGTGTT ATGTGCTGGG ATITACAGGCA TGAGCCACTG CACTCACCAA GCACTTCTAC TCUTAGAATA TTfAAAAATT CTAAGAGAAG AGTAAAUTGA GCCTTCCCAA CCTTCATACC AAAACTGGAC AATGCTTGCA CAAAAGAAGG AAGCCAATGA GGGCATTGGG CCCAGTGAGT CCTGGAAACC TCATCTGTGC CAGCCACCCC ATGAGGGTGA CTTGTCCACA GACAATAGCC ATCTAGCTGT GATAAAGGAG TCTTTCACCT GT'rrGCCAAT GTTACACAGG YJGAAAAGCT AAGGTTTATG 177 TAAAGCAAGC ATCAAAGATG ATGAAATGAT CAACCTGACA ATGAGTACTA TGCTGCATTG TCCAGAAAGG AACTGTGGAA GAYFTTGGGC CTFJTGATGU7 CAGAGGTGGT AAACCCACAA GTCATFTCCCT TCATCTCTGC TTCTAATAGA TCGCCTTATC TCATAGAAAG CTGTGATTCT AACAAGTGGA TFTCTCCGAT ATGAGTGGGC GTCAGGAATG AGTCACTTGC TCTTAGTCTA ATAGACTAAG ACTGGTCACT GTAGTCATGC GTGACCYITAA GCAAGGTATT AATGGGAAUT A'rrrCATAT ATTAAAGAGC CTGGGATATA CAGTTAACCA TTI7GGAGATG AGAATATGAA TAAATAACTG AT'TCTAGGC TAGTAYI7GAG AGTAAAACCC ATGGTAAAGC GAAGTAGGGA AGACGCTT-rA TGAATTTCAA AACAGAATU- CCTCACTCTC TGGATGTTGG CT-rACT-rGGC GCCMTGTGT TGTTGAACAA TGTTGATTTT GGAGAGAAAA CAGAGTTGAA GGGGAGTATr ACCGGAATAC AGAGGATAAT TJTCAGCAAGC CAGCAAGGCC TAGGAAGAAA GGAAGAGAGG AACAATACTT TTTTAAGAAG CTCAGCTTTA ATGCCTCCAG TCTGTCTGGC TAAAGGTAAT TGGCATGGGA AAGTCTTTAT ATGTTTCCCT TCATTAAGAG AGCCTTGTCT GGCTfGGGGA AATGAAACAC TGTAACCCCT GCTACTAAAT ACTCAGAAGA AATAAGGCGG TTGTGGAGCA CTCCCTGGAA TAY[CAGAAA ACTGAATCAA AAGTACATrC TTCTGGGTTT GGTCTCTACT TTGTTAAATT TCTGGGAAAC AGCATAGAAT GGGAGAAAAA

AAATCTGCAA

AACTCTCTCT

CATAATGCTG

TAGTTAATAT

ATCCGCCAAA

TCAATGATGT

AACAAACAAA AAAGTCTGGG TATTGCTGCT GAAT1TTCAGG TTCTTFCATCT GTTAAATAGC TAGCTT-rAAA AAATAAAATA AAATGGATGA

ATAGCAGCAT

GCTGCTAGTG

CTCAAGCCTA

GTAAAGATCC TGTTAGAAAT TAGAGGCAAC TGAGAATTTG GAAAAACCTA TCCATCTGGA AGGTCCTGGA CTGAGTGAAG( AAGCCCATTT CTTGGGAAAT AGCAAGGCTC TCTAGAGGCT CCTTCT-rGTG AAATGGATTC CTGTATGTTC CATGGAACAC TGTATAAAT

ATGCCACAGT

AGCATGTTAA

CCAATATACT

ATAAATATAT

TATAAATGCA

GGTTCCCACA

T-rTGGTTTCC

ATATCTAAAA

AAACTTTCTT

CCTTCAAGAA

YTAAGGTGT

GCTGGTGGAA

ACAACAATCA

CAATGCTCTT

TGCTGTTTTA

TCTTCCCCAG

CCACTAAAGT

GGCACCATAG

CAAATAAGTT

ACAGTCTTGA

TGA'ITATGGA

ATGCATGAGG

CAGCATTTAC

ATATCTCCAA

CAATGTATAT

AACAACGTAA

CATATCAGCA

TITTCC1TT

TTACAT[GTU

GGTCTTGCCT

AGTTTGACAT

TGATAGCATT

TCAACTAAGT

GAGTATATTC

TTJ7ATCCTGA

TGGAAACACT

GAAGTCCTGC

TAGTTTTT1TC

TCYTCAT[A

CTrTTCTGCA

AACCACATTC

CAAAGTTACA

ACACCTTAAT

ATAAGGCTGT

CTATTCACAA

AGCTAAAAAT

CAGTGTTGAT

CCATTATGTG

AGAGCAGAAA

CTTACAACAC

GGGCATACTT

TAAACTATAT

GGT1TATGA TrMTACTAT

TTAAGGCTGT

TTCACTTTCT

TTTG1TTTGAT

GCTAATGATC

GTCTGCTGAC

CTGGAGAGGA

AAAGATTCAA

TACTTCCCAG

GCCACCTCCT

TTGCTTCACA

CATTCTCTGA

TTrTAATAGAA

ACAGGCATAC

CCACTGCCAT

ACCATAGTCT

GGCTGGTTTG

TACTATTTT

ACAAGAGGAC

ATCTGAGACT

TGGGTGGCTT

TGAATTGAAT

AGACCTTCGG

AGATGCCCAG

TGAAGACTCT

TCTGCTAAGC

TATGCTFCCA

AATATTGAGA

C17GGAGATA

AAAACCAGCC

ATTATATATA

A1TMCTACC

TGTGATAGCA

TAGATTTTAG

TCAGCAAGTC

TGGCAATTrC TT'FrTTTTCT

TCAATCCTTT

1TTYCAACAAT

TATAAGAAGC

TCTACTTCTA

ACCCCYJ7AAA

CTGCTCCCAT

GGCTTTGCCC

AACTAGCTAT

ATATCTGTAA

GATAATCAGA

GCTAATTTTA

CCTGTCCTTC

TGGGTGGGAA

GAAAAGAAAC

TCTAGAAGAT

GAATCTCCAA

rGAAAAAAGA

AATGCACATT

CGGCAGTC

ATGACATGAA

ATAATCTAAA

CTATGGGTTT

ACATGAATTT

CAATAGCATT

CAGACCACTA

CITTTCCTTT

C'ITATCTCAG

ATAATCT1TT

TTAAAGTAAG

CTGTAGCCTG

CAAACTCTGG

GTTCACACCA

AGCTCCTCAT

AT-FCTAGFI7C

GTCACTCATG

GAT[FCATGGG

GGATCCATCA

ATCAATJ7GAC CCTTCCTGTC ATAAATGATT

TTACCCACAG

TTATGGAGTA

TACCTCAAGA

GATTGCAACA

TTGTGCTTAC

ACAAACTCCT

ATGGTGAACG

TAGAATTTTC AAAATTGGAG TTAGAAATCC CTTGTTGjTCA AACCACTTTC T-rTGCTCATC ATTCAGTTAC ATCTTCAGGC TTfTCTCCGCT GAAGTCTTGA TCTTGCTGTT TCTATCTCAT AGGGTITGGAA TCAACTTCTT TATITcT-rAAT GGCATCTAGA

GTTGATGTTG

T1TTCAGAAG

ATATTTTGAC

GT'TTCAGT-T

GACGAATCCC TATCTATGGA AGCTATAGAT TTATAAAATG TAYI7TCTI'TT TTTGTGGGGG CATAGCGTCT CACCCTGTCA CCCAACCTGG AATGCAGTGG CACAGTCATA ACTCACTGAA GACTCAAACT CCTGGGCTCA AGTGATTCTT CCACCYI7GGC CTCCCAAAAC ACTGGATTAC AAGCT-rGAGC CACTGTGTCT AGCCCAAAAT GTATATCATA ACTAATGAGG CTTrGAAAGTC AAAGTGACTC CYFGATCCAT GGGCTACAGA ATGGACGCTG GGTTACCAGA CATGAAAACA ATACTCATCT CCTCATACAT CTCCTrCAGA GCTCCTGGGT GAGCAGJGCCC ATTGTCAAAT GAGCAGTAGT ATCTTGAAAG AAATTTT1T TCTGAGCAGT AGATCTCCAC AGTGGACTTA AAATAGTCAG TAAACTATGC TGTAAACAGA AGTGCTGTCA TCCAAGCTCT GTITITTCCAC TGATAGGGCA AAAGCAGAGT AGATGGCA TAATTCTCTA GGGCCTrAGG AYTTTGGAA TGGCAAATTG AGCA'FrGGCT TCAACTTT TrTrrT TTT7TYIGAG ACAGAGTCTr GGTCTGTCAC CCAGGCTGGA GTGCAGTGGT GCAATCTCGG CCCACTGCAA GCTCTGCCTC CTAGGTTCAC ACCATTCTCC TGCCTCTGCC TCCTGAGTAG CTGGGACTAC AGGCACCCGC CACCATGCCC GGCTAATTTT TTGTATTTTA GTACAGACGG GGTTTCGCCA TGTTAGCCAG GATGGTCTCG ATCTCCTGAC CTCGTGATCC ACCCGCCTCG GCCTCCCAAA GTGCTGGGAT TACAGGCGTG AGCCACAGCG CCCAGCCTGT CTrCAACTrA AAGTCGCCAG CTGTGTTAGC CTCTAATAAG AGAGTCTGCC TGTCCTI7TCA AGCTTTGAAG CCAGGCATCA TTCTCTTCTC TAGCTATGAA AATCTrAGAT AGCATCTTCT CCCAATAGGA AGCCATTT7T TATGCCCTAA AAATCTGTCG 1TFGGTGTAG CCACCTJ7CAT CATTGATCTI1 ACCTAGATCC GCTGGATAAC TTACCACAGT GTCTACATCA I1TACTITCTGC 'rrCACCTrGC ACTTTTATGT TATGGGGATG GCTCC1TITCC TCTAACCTCA TAAACTAACC TCCACTAGCC TCACATTCTT C1TFACAGC Y-FCCTCGCCT CTCTCAGAGT TCACAGAATr GAAGAATGTT GGGCCTrGGA TTACACTTTG GTFFAAGGGA ATGCTGTGGC TGGTT]TGATT T-rCTATCCAG AACACTAAAA CTTTCT-rCAT ATCAGCAATA AGACTGTrC ACTTTCTTAC TATTTTI7GT GATAGCACT-r TTCCTTTCCT TCAAGAATTT TTCCTrTCTA T7CACAAT-FT GACCGT7ITGA TATGAGAGGC CTAGATTfA GCCAATCTCA GTITTACACCA TGCCT1TTTC ACTAAGCYJ7C ATCATFTrAG CT1TFIAT AAAGTAAGAT GTGTGACCCT TCCT'FrCA~r TGAACACTTA CATGATGATG CCTGGCTTCA AAGCTTGAAA GGACAGGCAG ACTCTCTTAT TAGGGGCTAA CACAGCTGGC GACTTTTAAG TTGAAGCCAA TGCTCAATTT GCCATTAGAA GCCATTGTAG GGUTAATTAA TTTGCCTAAT TrTAATATTA TGGTGTCTCA GGGAATAAGG AGGCCTGAGT AGAGGGAGGG AGATGGGGAA ACAGCCAGTC ATCAGAGCAC ACACAACATT TATCAATTAA GTTTATCACC TTFGAGGGCAC AGGTCATGAT ACTITCAAAAC AATTACAATA ATAAAATAAA AAATCATTGA TCGCAGATCA CCATAACAGA TATAATGATA ATGAAAAATT 178 TGAAGTATTG TGAGAATTAC CAAAACGTGA CACACAGACA CAAAGTGAGC TGCTGATAGA CTTACTTCAT GCAGGGTTGC CACAAATACT CAATCTGTAA GTACCATAAA AACAAGGTAT CCCTAGCTCG GAGACATTCT TGTCTCAGCA AAATTGCAAA TGTAAGCCCA GAGACCACTG CACTTGGTAG AAACAAACAA TTACCTACAT AAGCAAAAAT GACTTrAGACA CTCATTITCC CATTTGTJTTT GCTGAGTGAT TGTGTGAATT TTTCATGGCT GCATTCAGTG GTTTAAGTTG CACTGATTCA CAAATAAGCA ACCTGTTTAT ATAATCAAGA CCAACAGAAC AACCAACATA CACTTACCYF TCMrTTGCT GTATCAAATG TCATGTCCAT CTAATACTCA TATATACAAG TGTTGCTATA AGCATTAGTT AAAGAAAAAA AAAGAAAGAA AAAACATTTT ATGAGATGTT CTCTTATCAT T1TTTCCATCT TTTTTGTACG TGACCATGTA AAAGTTCAAG GGGTCCCTAA AAGAAATTTG GCTTTFGCT1T AATGATTTTT AGAACAGTTG TGATGTGTTT GTFGTTATAA AATGAAAGAA TATGAAGGAA GCTTCTCTCA AAATGTTGTA ATTACAAAAA ACATGTCATT GGAAAAGTGG AAAATTCAAT TATCTACATA CCTAGAGAAA ATAGCTCACT GTGTACAGAA TTCAAATCCC AAACTGCAAA TGTTAAGTCT CTTCTCCAAA GAAAATAGTC TTACAAGAAG ATTCAGTCTC ATCTTATAAT CTTTGGTGCT TCAAGAAAAA CTTGTTrTGA TGAAAAGTTC AGCATGATAT AGGTGTTTTA AGAATATGAA AGCCTTCTTG TCTTAGAACA TTCCAAGGCA AATATAATAA TGACAAGGCA AAAAATATAT TATAAGGACA AACTGTTTAA AGGGAAAACA CTCAGTTTCA TGGCAATATC TAGCAAAAGT TGAAGATACA CCTCAACAAT AAATATT7AA AACAACCTAC AAGTGCAATT CACYJTATGT[ YJ7AGTATAAG AAAGGGGAAA TAAGTAAGAA ACTAGTAAAA CTTTGAGTAT ATGTTTATAT ATTAATCAAC AGAAATAACA ACTCCTTGTC GGTGCTATGT CTAGAAACYI' AACAGCCCCA AAGAAAGTCC ATATATATAC AAATTGTGGA AGCAGGGTGT TGAAAGAAGA ATAAAGACTA AAGGGAGGGT ATCCTTGAAA GCTTGACACT TGACTCTTT[ GACGAGGCTG TAGATTGCTG GTACGGATGT AAAATAGTGA CATCCCTATA GAGAGGAATT GCTTATGCAT TTATTCTTTG ACCTAGTAAT CCCGCTTCTA GGATrAGTGG AAAAATATAT ATACATTAGG TTATTAGTTA TGGTTTAATT TTTAATAGCA ATGAACAAAT AGGAGACT-FA CTGAATAAAC TATGGTATAT CTGTACAATA GTTAATTFTGT TCCAAAAATC CAGAGCCAAA GAGTATTTGT TATGCTCTCT TAAGATATGT GTGCATCTGT TTATTTTTGT GAAAATAAGT ACAGAAAGGA CTAGTTATCT CCTAGTGTTA GTAGAAATAG AATGAAAGTG AATTAGGCT7 ATAGTTTrTGA CTTT-FGAATT ATGTTTATGT TTACATAGTC AAAAATATAA AAAAAAGAAG AAATCACAAG CTTTAAAATT TAATACAAAC AGAAATAATT GAATCTAACA GTATATCAAA GTGATAACGT AAACTCAGAA GAAAAAAACA TAATCCAACA TACCAGTGGA ACACAATATT CTAACTGTAT ACATTCAGTG GTTATAGTCT AAGGACAAGA AAAATTGCAA AAATATCTTG TrATTGGTAG CAATACTAAT GTACTAAFC TGAAATTAAT GTITCGTGTAT TAAATATGTT GATGTTATTG GGAACTAAAA 'FrATCATTCT GGGAGTAGAG CAAATGAAAC AAAGACCTGC AGAGAGATAA CCATATAAAC TCATTATTTT CTCTGTTACT GAAAAGGCCT AGATTCAATC TTATCTTGAT AGACAGGAGG GGTTTCCAAA TGCCATTCTC CATTAAAAGG AACAAGGTCT TCT-rGGAGAA ATTAGGTAAA GTACAACGTT AGTCTGGAAT TTCTTGCTGA ATCAGAAGTA GGAACATGTC ACAAACACAC GTGAGGCAAC TTGAATCCTC ACTGGCCATA AAAAAAAAAA AAATGTTGAG AATAATGGAT TCTAACACTr AAAACAAAAA GGGGAAGAGA GGGGGAGCTC YI7ATTTACAG ATGAATATCA AATAGCAAAG AACTTTAGCT TGTAGGATTT TATAGAATTG AGTAAATGAA AAATATAAAT ATGGACTTGG AAAAATTATA AGTGTCCTAG GCACCCC17 CTCAGAACAT AAGACTGATT CTAGGTCTGG AGAAAGTGCT CAAAAACATG TTTAGGACAA TCGAGCATCA ATAATCCATA GCCCACAGAA ACAGAAGAAA TGACAGAATT AGAGAAACAT CATTTTGCAA AACACCACTG TAATAATCAA T-rCAGGCAAG TAYI7ATTAAT GGATGTATTA CTATTGCGTA AAACCAGTTG GGGAACAGGA TATTCATACA GTCTGAAGGT GTCACCCTAA ACATAACTTA TJ7ACAAGTGG AAAATGGTGC CTTTACAATG AAGAAATCTA GCAGAAACCA TCTTAATCTA GTGATCAAAC ITAGTATCAC CAATAATGGA TCATACTGAG TCATGTGTCT CCTAATATGA TGCACCAGGA AGGATGCAAC GTCATGAACG YrFGTATrCTT TTIGTATTCAA CAGACCACCC AGGGTAAAGG CAGCTTTCTC ACTTACTAAT CAGAAI7GTT GGTTrAATT CATTTTGGAT TTTAAGATTT CTTACTTTCT TGTCAGCTCA GAAATTTATT TAAGATGATT TTTATC'I1T[ ATrCAATACT 11TAGCTrfGGA GAACCATTCA GAGTTrCTAA CTCATFFGTAT TGCCAAAAAT AGAAAACAGC ATGGTTTCTT TTGAAAATGT CTAACITTAA AGTTACTTGT GTGTGTCACT CAGATTCACA TAGCTTFT GCCTAGTAAT GTAGTATCAT GTGGCAAGGC TATAAAAATG TTTACAATCT TTTATTTAAT ATGACTCTTG AGAGTTTATT CTAAGGAAAT AATTGAATAG TAACAAAACA CTATTAACAC AAAGCATAGC AATTTGATTr GGGCAACCAA ACACTGGAAA CAACCTAAAT GTCCAUTACA GGAATCATT ATGAAGCAAA CACTAAAATA TTTATTGTGA AGATJ7ATGAG AACATAGAAG ACAGTTATGA GAGTAAATTT GAAAACCTGA ACACAAAACT TACATATACT CCAATTGTAA CTITATAAAAA ATACGTGCAT ATAAGGATAA AACAGTACAA ACAAAAAAAT AGTTGCGTTA GATTGGTAGA ATTATGGCTC C1TTGCTGT CTTAATTTTT TCCT-FTTACA T1TGATACA UTATTTTAAT TTTrAATTTTA AAATTCAAAA GAATTTGCCA CTCATCUTTG CCACTTCAAG GAAAAAAGAA ATGTGTTCGA 'rrATrCTGTT CTTAGTATAG TITTTGGCAAT TTCCTCACGT GTAAAAAGAG AATACTATTA ATAATTTCAG TATCTATAAG ACAATATAAA ATFAAAGAAT CTAGCCCAGT AACTGGTACA TGGAACGTAA TITAATAAATC ATTATGGACT T-ITTTCTCA CACCCAAGTA GGGAGGAATC AGTGGTCCCC TAGAGOCCCA GTGTAGAGGT GGCAGCACCA ATCCCTAGGG GAGAAGATCT TGGTGATGAT AA11'CCTGAG CAGACAGUTA GCTGAGAATTr CAAGAGCAGA AAAGTAAGAA AGAAACAACT TCTTGCTAAC ACCYICCAC CCACGTTTCC CTGTTCTGTT GTACTCTGCT TACCCTrTCA TGGATGGAGG CAGAGGAAAG AGAACCAAGT TTGCTCTTAG TCATTCACTA TGTTGTITTAA TCTGCCTTCC ATCT[CTTA TCAGU-CAAA TTAGAATGTA GACCTGAATr TAAATCCCCG TTCTGTCAGT TATAATGTGA CCCTAGACAA AACACATTCT CTGAACCTCA GAGAACATrc T7CATTTGTA GAATGGGAAG ATTAATCTAT A1TcCACTrrG GATGGCAAGT CTITTrATAAA CTITTATAACC TAAACATGTG TGAGTTrGCTA GTATCATTAT GTTGGTAAAG T-rATTCTGAG ATATGATAAC AGAACTGT TGTCTAACTC CACTAGCATG GTCAGG1T AGAGAGTGTG GAATI7AAAAG GCTTTATCCT CAAATATGAC T-rAAATCCGA TTI-rCTCAT CCACmTCCT CCACAAACAA ATCCTCAGGA AATGACAAAC TTTACATGGT TAAACATCAG TITTGTTTAG TCTrrGACAT CCACATGGTT AAATCATACA -17TGAAAACT GCTTATATTT GTGTTGTCTA TGTCTAAATT GAAAAGACTr ATTGAGGAAT AGAAGACTAC ACATTICA GCAAACACTG CACGTTTrGC AGAAITTCCC CAGGjCACCAG TCTCCAGGAA ITFAT-rGGCT ACTAACAATA CTAAGATATG GATGAATGAG GAAATCAAAA TGGAGATCTTr GCAAG=f~TG TGAGAATGGG 179

TGAATGGTCC

1TIGTCAAT

TAGGTATACA

CTATCTAAAC

TTAAATTAAC

CACTCAGTCA

TCTCTGCAGG

GAACTCTGCA

ACAACGGCTT

TGCAATGGTG

CCTGAGTGGA

'ITTCTCCACG

GTGCTGCGAT

CACTCATTTC

GCCTGGCATA

AAATGAAGAG

AGCTATGAGA

TATAAAAAGT

TATGGTATAT

TTGGCYJTGGG

CTTATCATGC

CAGGCAAATC

ATGTACGGAG

TGT'FfTGTTT

TGATCTCGAC

TGGGATTACA

TTGGCCAGGC

TACAGGTGTG

ATGTTCTTTC

AGGAAAATGA

GCAGACCAGC ATGGAAAGAA AGGCAAGAAG TATGCTTTTG

CTITACCTACT

CACTCT-TCT

TCCAAACTGC

CCACATGAGT

TTTCTCTACA

ATTAYI7CTGG TTrAATATGCA

TCGAGAGAGT

TCCTCTGTAA

CATGCCTGCA

GCCTGGCCCA

CTGTAGTCCC

AGCCGAGATT

TGGCACTGCT

ACAGAATTrG

TGGTTGCCCT

CTCTCAGACA

AATTTCCAGT

TGATAAAAAC

TTCTTfTGGAA T11TATTYJ7CA CCATATI7ACT

GTTGTAGAAT

TACTAGCTGG

TTTATGAAGA

CATGGTGGCA

GAACTCACTC

CCCCCCATGA

CATATAATTrC

AACTGTCCCC

CAAGGCAAGT

GGGTACAGGC

CCATGCAAGT

TGTCTCACAT

GCTTTGCAGG

ATGAGTATGG

GTAATCCCAG

CACGGTAAAA

CCCAGATACT

ATTGTGCCAC

CTGGGGTCTG

CTCTGACCCC

AACTTCTGCC

CAATTCTTGA

AACCCTCTGA

CATGAGCCGA

CTCCAGGCCT

cTYrGGTAACT

YFTCTCCCCA

TATGCTTCCT

CACTTCTCAG

GTTCTTTAGA

TGTTAAATGC

T~rTTAAGTT

TTATTGAGCA

GGTCAGTCTC

AAATGATTTT

ATTGACT-rGT

TGGGCAACTG

ATCCCAGCAC

CATGGTGAAA

AGCTACTCAG

GTGCCACTAT

TGGCATCTGC

GGTCTCCCYr

AAACTCGGTC

AAATAAAAAA

TGCTTTAT

TACTCCCCCA

AAGGATTYI7A ATAAGTTGTG AAATA11TAGT ACAAGTAAAA ATrrACCAT TGACCCAGAA A11TCCATTC TATTCATTAC AGTATCGTY[r TTCATAGGAA CTAGGTCATA GAAATCAAAT GACTAAAAAT TCTTCAGCAA AATTGGCTTrC TTAACATTGC AGGAGGAGAC TCCTAATACC ACATATCATA CCAAAGAGAA GGGAGGAAAG GGCTGAGACA GTGGACAGTG TCCACAAAGA TTGCTCCCCT TTGTTTTTGT ITI7TTGACAC GGAGTTTTGC TCACCACAAC CTCCACTTCC TGGGTTCAAG GGCATGCACC ACCATGCCCA GCTAATTTTG TGGTCTCAAA CTCTTAACCT CAGGTGATCC AGCCACCGCG CCCAGCCCAC AATGGCCTTT AAGAAGAATA CATAT'ITCAT CTITTTAITr TCATTAAAAG CTGGGTGAAA AACCTAATAA AACTATGAGC CAGATATTGA CATCATCCTG GAATATAGAA AATCTGGATT ATGATAAGAA TYTCCACATGT TTCTGAGGCT GTTTGTCCTT TTGGATCATT CCTATTGAGC TGACATCAAG ATCCAGTGAA TTTTTAACTT TATATAGTAT TCCATTTCTC TGCTGAGATC TCCTATTTGT TAATTATAAC AGCTCTTCTA AAA'rrCTrGT TGTrACATTG CCY[AUTACA AAAACAGTAT TGATTGCAGA CTAGACATTf TGAATTAAAC YfT[CCATC AGGCAGGTAA CTrGACTGGA CAGTAATCTT TGTTTAGTTC TTTAAGACTT TGTGGGAGGC CAAGGTGGGA GGATCACCTG CCCTGCCTCT ACTAAAAATA CAAAAATTAG AAGGCTAAGG CAGAAGAATC ACTTGAACCT ACTCCAGCCT GGGTGACAAA AGCGAGACTC TATGAATACA TGAAGTTCAT GGGTCAGCTA TCTCTGGATT TCTCCTTTTC TGGATTTCTT CTCTGFITCT TTACGGCAGT AAGATTI'GGG TAATTTTCAT CTTGATGCTA CTCCTTTCTT TGCTCTCCAG AGTCTAAAGA TTATCATTGT AAACTGGAAG CTGGAAGCTI' GTAATTATGA ACTACTCCCT ATGTACTTCT ITAT7TCCTG ATTATTTACA ATGAAAGACA TTTCTTCAGA AATACCCACG AAAGTTTTAA AAATCAGAAG GTTAATATAA GCATATGTTT ACTCCAGAGT TAGACU-ACC GAGCAGAGTA GGACACAGGT CTGCATGGTC AATTFCTTCT

GGACCCACCA

TCTTGTTGTC

TGATTCTCCT

TATTTfTTAGT

ACCCGTCTTG

TGTTTACATC

TATACAGCAA

AGCTACTGAG

AAAGGCAGAA

AAGAATCATA

ACTTTCTTTT

TI7AACTGACC ATCTTrTAGT TCATrCATTA CTGCACA17C

AAGTCACATT

ATTATAGAGA

CTCAAACTCC

ATTGGCCAGG

AGGTCAGGAG

CCGGGTGTGG

GGAAGGCAGA

CCTCTCAAAA

TAGATCTGGG

TITCTCATrTT

AACTTT[AGG

CCAGATGTAG

TTTCTGTGGG

ATAGACTTTG

TYT[CTCAT

TGACTGCTAT

ACTGTAT[

TAGAATCCCA

TCATAATAAC

CAGGCTGGAG

GCCTCAGCCT

AGAGACGAGG

GCCTCCCAAA

TCTAGTGCAG

TTAGCACAGT

GATAGGAACT

GATTTAGTAT

TYUGTCTTAT

CTG'TITATC

TIT7TATTrTG

CCTAGAATTT

TGACCATATT

TAACACCTGA

GCCTTGTTTC

TTCTGGATTC

AAACTCTAGG

CACGGGGGCT

TTCGAGACCA

TGGTGGGCGC

GGTTGCAGTG

AAAAATTTAT

CACGTrFATAC

CCAGCAGCTG

TTTrTACCTGC

ACACCTCTCT

AGAGTTGGTC

AGTAGTATTC

CCGTAATCTT

CAAATGACCC

AGTAAACAAT

GATTCTAACT

GACTGGGTAA

AACTTACAGT

GATCYITATGA

CCACCAGTTC

ATAGCCAAAC

TACTTCCTAA GTCAGACAAT TTTCCTACTT GAAGATTCAG

AAATACAATA

AGTAAAATAT

TGTATTAGTC

AAAGAGGTTT

GCAAGGAGAA

ACTATCACGA

CACATGGGGA

CACCCCTGGC

CAAGGTCT-rA

CCCTTCTGCC

TCCCCAACTG CATTTATAAA AAGAAAATIT TGCTGGGCTT TGGAGCCAGA TAATCAAGGT CUTTCTCATG CTGCTAATAA AGACATACCC CAGACTGGGA AATTGACTCA CAGTTCAGCA TGGCTGGGGA GGCCTTAGGA GTITCCAAGCA AAGAGGGAAA AGCCCC17AT AAAACCATCT GAACAGCATG AGGGTAACTG CCCTCACG'IT TAATTACCT[ ITATGAAAGC TATAATTCAA GATGAGATTT GGGTGGAGAA

CCCTCTCAAA

ACTCATTCCA

TATGAGCCTA

GTTGGGTAAA TACACTGATT CCAAAACCCA ATAGGGCAGT CCAGGTCACA CTGATGCAAG GTATAGCCTG CTTCCTGTTT TGCAAGCTGT TGGTGGATTT CACTTTGGGA GGCTGAGGTG CCCAGTCTCT GCTTAAAAAA TGGGAGGCTG AGGCAGGAGA TGCACTCCAG CCTGGGCGAC TCTCATGTCC TCACATTI'CA AAACTCAATC ATGCCCTCCC GCATTAAGTC AAAAATCCAA GTTCAAAGTC TCATCTGAGA TAAAATCAAA AGCATGTTAG TTACTTCCTA GATACAGTGG CCAAATGGGA GAAATTGCCA AAACAAAAGA GTTACAGACC CATTAACATT AAAGTTCCAA AATGATCTCC TTTGACTTCA AGGTGGGCTT CCAATGOCCT TGGGCAGCTC TGCCCCTGTG GCTrTCAC AGGCTGACAT TGAGTGTCTG TGGC=TTCC ACCATJ7CTGG GGTCTGGGCC AGGTGCAGTG GCTCATGCCT GGGGATCACA AGGTCAGGAG ATCGAGACCA TCCTGGCTAA TACAAAAAAT TAGCCAGGCG TGGTGGTGGG TGCCTGTAGT ATGGCGTGAA CCCAGGAGGT GGAGCTTGCA GCGAGCTGAG AGAGCAAGAC TCCATCAAAA AAAAAAACAA AAAAACCATT CACCACCAGO CAGTGCCCCA GTGGGGACTC TGTGTGGGGG CCTAGTAGAG GTTCTCCATG AGGGTTCTAC CCCTGCAGCA TACATCCTCG GAAATCTAAG CCGCGGAGGT TCCCAAACTT CAATACCACA TGTAAGCCAC CAATGCTrGG TCAGGGCTTG

GAGAATGGTA

ACATJ7TCCCT

TGGACATCCA

CTCCTGTGCA

AGCAATGGCC

AGCTTCATAA

GTGATGGGAA

AACATTCAGC

GAAAACAGGA

GCCCIrACAG

TCTGCACGGC

GGCAIT77CCA

CCCACAGGCT

TGAGCTGTAC

AGTGGGAGGG

GGGCAGCCAT

TCCGTGTGCA

TrrrrCTTrr

GTTGACACCT

CCTJTGGGACT

GAAGGTGCCT

GCACCAACTT

CTAT-GCATC

GAAATTTCTT

180 TTTAGCCTAG ACATCTAGGA AGCTGAGGAA ACCATTrTTC GACATGCCCT GGAGACGTrT ACTTATGCAA ATTTCTGTCA ATCATGCTGC AAATTCAA CCCCCAGATA CCCAAAATrA

CACAGGGAC

CATCCTAGGC

TCCCCATTGT

CTGG'TGAA

AC1TTTATGC TCTCTCTCAA GTTGAAGACT TTGCGGCITA GTTCAAAGTT CCACAGATAT CTCCAGTTCC CAACAAGTTT TATCAACATr TTGGTCAAAG TTCTAATAGC CCTCCAAATT GGTATCTTTA CAGCAGTGGC AAAGACTTAC TCGAGACTGG GGAGGCCTCA GGAAACY-FAC TATAAAACCA TCAGATCTTG AATUTACCTC CCACAGGGTC CTAGGGGACA AAATGTTGCC CTCATCTCCA TATGAGACCA CCATTCAACA AGTCTCTATG TTTFCCAACCT CTGTCTGTTA ACTCCCCATG GTACTAATTT GTAATTTATA AAGAACAGAG AAACATGGTG GCAGCAAAGA TGAGAATTCA CTATCATGAA CCTCCCATGA CAGGTGGGGA

GGGTGGGGAC

GGTYJ7CCTAT

AACATAGCCT

GTAGACTTTA

GCACTCCCTA

TATAACTGAT

TGGTGTfGTA AATAGTTrCA

AACTACTGCT

ATGTAGGATT

GCTTCATAGT

ATTCACCTAT

CTATGTACAT

TGGATTGTAT

MTGCAFITCT

GTTTTGAGCA

ATAGAGAAAG

CACACTTGGT

GGCACACATG

TfTUTGAG

GCTCCGCCTC

CACCACGCCT

GATCTCCTGA

GCCCGGCCTT

ACAGCCATAC CATGCCAGCT AGAGAGCCTT TTGTTCAACA AAAATAATGA CACCCCTTTT TGCATAGTGT CTGGCACAAA ATAGCTACTC TTrTAGAG TTrTATGTAC AAAGCAAAAT CCCCCAAGCA CAGATAGCCT CCCCCAGTAT GAATCTATAT TGACGTGTCA YITTCATCCA CCT7CTATGG GTF-rGACAA ATGTATAATG CTGTCCTAAA AATCTT-rGAT CTTCUTCCTA AATYITTCCTG TCTCCATTGT TTTGTCTTTT TTCAAACTGG TrrATTTCAC TTAGTAATAT TCAATATTTA TAGAATTGAA TAATATTCCA CAAAGAACAC CTTGGTTGCT TCCAAGTTTC GTTTTfTGT GAATTGAACA TTT-rCAGCTT GATAAGGGTA TGTAGTGT TGTAAGAAAC CACCAGCAAT GAAAGAGTTC CTGTTGCTCC ATAGCATYI1 GATCTAAC'rr TTCCTAGGTA GATATACGAG GACAGTTCTG TCCTTAT17

AGTCTCTTTG

TCTCAGCTTG

AAGTTTCAAA

CCCAGTTCTA

ACTGTATTAG

GTTCAACTGG

GAAGTTCCAA

AATAGCATGA

TTATGGGAAC

AAGAAAGTCA

ATGGGATTTC

AAAAAATAAT

TGAGCAGAAT

CAGCATCCCG

AAATCCATAG

ACATGTATTC

TTCATCACTC

CCTGAATGTC

GCATTTGATG

TTGTCTGGAT

AACAATCATG

TYTTTAGCTCC

TGCCACGCTC

ACATACTCAC

TTCYITTTTGA

ATAGTCCATC

ACTCTGACAA

CATAGCAAGA

GACTTAGTTG

CTTCCCCATG

AAGTCACTTC

TCTGTJTCTCA

CTCACAGTTC

GCAAAGAGGG

GGGTAACTGC

TACAATTCAA

CCTAATCTCC

TGTGAGGACA

AGAAACAACA

GTACAGAGAG

CACCAGAGTG

TTTATATTAG

ACCATTACAG

CCTCCCCATf

ATATAGTTTA

TTCCTTCCATA

GTACTACAGT

AGTAAAGCTG

AT7CCTAGGA

TTCCTAACTG

CAGCATTTGG

kGGAAATAAT

ATTTAATGAA

TCTCCTAAAT

GTGACC1TTA

TCCATGTTAC

TTTTCCTGTC

TACAT'FTTG

TGCTGCTAAT

AGCATGGCTG

AAAAGCCCCT

CCCCATGATT

GATGAGATTT

ACAAATAAAA

AATGATAACT

TTTAAAAAAT

TUTCCGTATA

GTACATTTAT

GGATGCCTCT

TATCATAAAG

AATCCCTGAC

AATATACAGT

TCTTrfTCAAA

TTATGTATTC

CTATAAACAT

GTGCAATTGC

GATGTACTGT

TGTCGTCAAT

ATGACAGATA

GGACTCTGTC

CCCTGTTGCT A1TTTTTAACT

GTTGTGTATC

ACGGAGTCTC

CCGGGTTCAC

GGCTAATr'rr

CCTTGTGATC

TTTTTTTTnT CTGATCCTCC TCTCCCATGA AGGCCCCCTG TGGTCTGTCT GAAGCATGGC TT1TT-TTT TTTTTFTT GCTCTGTCGC CCAGGCTGGA GTGCAGTGGC GCCATTCTCC TGCCTCAGCC TCCCGAGTAG TTGTATTTYIT AGTAGAGGCGj GGGTTTCACT CGCCCGCCTC TGCCTCCCAA AGTGCTGGGA 'TITMTT-[ UTTGAGATGG AGTCTGTCAC CTACAACCTC CATCTTTCAG GTTCAAGTGA GCGATCTCGG CTCACTGCAA CTGGGACTAC AGGCGCCCGC GTGTTAGCCA GGATGGTCTC TTACAGGCGT GAGCCACCGC TCTGTCACCC AGGCTGGTGC TTCTGCCACC TCAGCCTCCC AGTGATGCAA TCTTGGCTCA AAGTACCTGG GATTACAGGT GCCCGCCACC ACACCCAGCT A1TnTTTTGT ATTTTI7AGTA GAGACGTAGT ITCACCATGT TGGCCAGGCT GGTCTCATTC CTGACCTTGA GTGATCCACC TGCCTTGGCC TCCCAAAGTG CTGGGATTAC AGGCATGGGT CATCACATGT GGCCTGAAGC ATGACTGTTG CTTTAATCAT ATGAAATACT GCTCTGTATT GTTATCTATT TGAAATGCCA CACCTCCTGA GCTAAATTGC AAGCTTTTAT GGAGCACAAA CCATATTTAT ATATATTAGC ATGATACCAT GACACATATC AAAAGCTGTT ATATATTGTr ACGTGAATTG ATTCTTTCTC AGUAAGAGG ACCTCTGTAG TAGCACT-rTC ATACCGTTAA YFFI17CATr TGTGCCCAGC CCCTACTCTG TGAAAAATGA AATGAATCCT GTTATCATTT CCCTCCCAGG CCTTTTCTCC TTrGTGGACAA TGTGTGGCTC AAGAGAAAAT TCAGTCAGTA AATFI'GTTrCA GTGCACAAAC TCTTTATCAC CTCTCACTGT TCTCAAGTGA GATAGAACAG AACATCCATC CAGTGTCTrA CAAATTGTCT GGTATATAGT AGGCACTCAA TAAATGTTTT TTGAATAAAT GCATACATGA ATCCTATTCC TATATATAGT ATGGTAGACA GATCAT1TGAT ACCCAAAGAT GCCCAAATGC TGATCCCCAG AACTrGTGAA TATOTTACAT TTCATGTCAA AAGGGACTTr GCTAATGTGA TTAAGGATTC AGACCCT7GG ATTGTAAGAT TATCCCGGAT TAACCAGGGC CAATCTAATC ACATGAGACC TITAAAAAAGC AGAAAACATT TCCCAGCTGG GTTAGAGAGA GATGAGACAG AGTAAAAAGG AAAGAGATTC AGGGCATGAA AATGACTCTA CCCACTGTUG CTGGCTTTGA AGATAGAGGA ACTAGGCCAC AAAACAAGGA GTATGAGTGG CCTITAAGAAA TAGGAAAAAG CCCTCATCTG ACAGCCAGCT AGAAAGCAGT CCTCTGACCA CAAGAAATTG GATTCTGCCA ACCACTCAAA TGAGCAAGGA AATGGATTCT CCCCTAGAAC CTCCAGAAAG GAACACAGCT CTGTAATGCC TTGATTTTAG CCAGGTGAGA CCTGTTrTCAG ACT1TrTGACC TATGGAAATA TAAGATAATA AAGTTTTATT GTATGCTGCT AAATTTGCGG TAGTTTATrA CTGAAGCAAT GGAAAGCCAA TACAGACAGA ATATACAGAG AGAAAGAGAA TGAGTTCTI7 CCTGATAATT TGTAAATATT TGGGTCTTCA CTGGACAAGC TTCACAGAGG ATTCACTGGT TCCCTAGCAA ACCAGCATGT CCAGTCCTGC AGCCTCCCUT TCTT1AGGCCC AGCATATGTC AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA CCCTGAGTAG TTGGAAAGAA AAGATGGTTG GAAATGGGTT GCACTTCAAG TGAGGAAACA AGAGGTAGGA GACCGGCATC TCT'I17CTCAT ATGTCCCAGG CTGACTC'rro TGAGTTGTI7 TCCC'FrGGAG GCTATCGATG ACAGTCACAG TAACCTGATG GAACCTGGAT CATGATGAAA GAAGTAAGTG TCAATGGCTC CGACT"TCCAA GGACTCTGAT GTCCCACAGC ACTAGCTAAA CAAAGCCAGT TGGAAATGAG CTTAAATGGG GAATCCTG AATATATTCC CTATTGTTAG GAAGCCAGGT TGGCTTCCT7 GCCTACAATT ATGCCAAGCA GGGACATGAT ATFTAAGTGAT TCTITrTAACA CAAACAACTr AATAATCATT CAACGGCTGA TATTCCACTT GAAGTAGAAT TGGCTATCCA ACTGGAAGAG CCAGGGAGCC ACTAAAAGGA TrGGCACCTG CCTCTGGAT7 CCCCTITffCC GGCAGGCCTT TATTI7CAGGA TACAGTTTCA CAAGTATTAT GTCACGTCTC ATT-rGCTCCT CTGGCCAGAA AGACCTAGT-r TGGAGTCTGG AGTCATGAAG GACATAAGTG TAGCTAGTAA AAATAGTGAG TAATGGCCCT GAAATTCTAT CAGGAACAAG CATGCTCTAG CTTATCTCAC AAGGAACTI'G ACAA1TrCT 181 GTCACACTAT AGAGTCCCTA TATACTAATA GCAAAACGGC AAGACAGGAA GACGTGATCT 'ITATATTACC TCTCAGCACT TGAGAATTAT GTTGGTAGAT GTGACATACA TGTAGCTAGT TGAATGCCCA AAGTGCTGAC TCAAAAATCC TAGTAGCTAA GATTTCTTAG TAACAAAGCC ACTAAGGCAC ATTCTATAAA ATATTACAAC TAATAGTGGA TGTCCACACT GGTAAAATAA GTTGTTTCAT AGTCCAGAAC TTTCCCCAGA ATAGGTCTAT T-rGGCAATTT AGTGCTGCTT ATATGTGACC TACTTACTAA CTCCAAGATG CCTGGTCTCA ATATOTAGAT AGTCACAAUr GCTGGTTGAT AATGGACCAA TCCAAATAAT GGATTAAACA TCAGTGTCTG GCTTAGGCAG TAAACACTTT CTAGGGGAAA ATAATGAGCT CAAGTTTTAA TCCAAGAGGC AGTTGGAAGC AACGTTCCGG GAAAAGGTAT GGCCATTCTG GAAAACTGTT GCAATITGTAC TCTTGAGCAT TTGTCCCAGA ATATACATGA AAGUTCATAG AAGTGTTATT AATGCTTAGG CAAACGGTGG TCTATCCATA GATACATGCA ATAACACAGA TGAATCTCAA TGGTATATAC TGTACTAT TATTTACYI7A Y7AATGGGTA CTGTGTTFG GGATGGGGAG AAGAGCCTTG TGGTlGAAGG ATI7CTATGTC ATTGTATGGG TCTACATACG CATACACACA ATTGTGCCAA CATCAGTATC CTAGTTTCAA ACTGGGTAAA GGGAACACAG GACATT-rGGC AAATAACAGA TATACTACAT ATCAAAAATT TGTTAATATC TGCTATAAGA CTACTGAAAA CCTITCGTAAA TGAAATGAGC AAAAGAAATG.

CTrCCCCATA TAACTATATC TGCGACTTCA GAAACTTTGG ATAACAATAT GTTTTCACTC AAAAAAACCT CACCAATT-rC ATGCTGTGGC AGGCT-rACTT GAGCCCAGGA GTTCAAGGCT GGAGTACTAA GCTAAGAGCT AAGAACACAG CCCACTCCCC TCATTTTACT GGAGTGAGCT GTAGCAAAAG TCATCAGATA 17TTTCCACC AATFATGATT AAC11TGACCC YITAGGTGACT TCCAAGCCAG CACACTCTGC TATATAAGAT AAATACATTA GAATTCATTT GCACTT-FCTA GTTTTGCAAT CTGCTACTCC ATACAGAGAT AGTTAGTCTG TTTTACTTAT CTATGCCTTA ACTTGACAAA AATACCCCAA GTTGGGAAAT GATGATCTGT CYT-rCCTGT ATTTGAGAAA TGGGAATAGG TGAGAGAGAG AGAGGAATAC CGTTAATAAA GACGGAAAAT AAAAAAGGAA CACTCTGAGT TCCCGGATGT GAGACATCCA AGCTTAGGAG AGAGGCATGA CCAAAAGCTG TGGCAGTITC TTAGAAAATT AAACATGTAC TAAATGAAAA AAAAAAAAAG CATTTTTTT CATAAAAAAC TGGAAAAAAC TGAGATGTCT CAATGGAATT ATGCTTAGCA ATAAAGAGAA AGGAATTAAT GCTGAGTGGG AAAAAAAGCA ~CATT17AAA AATAGCAAAA TCATAGAGAT rGAGAAAAGG GTAAGGTGTA AATATAAAGG TTGGTTGTAG TCGTGATTGC AGGAATCTAC AGAGCATATA AAACTGGTGA CATGTGAAGA TATCAGACTA CAGTrATACA AAACATTGTC

'TTTAAGGACT

TAATTGACAG

CACAGCCCCA

TUGAGTTCAC

AACATTACTA

CCTTATGTGA

ATGGAGATAA

ATGGTGGCTC

TAATTGGTGT

GGCGCATTTA

GTGGGACTGT

TAACAACCCA

ACACAAAAAC

TTATfGAGTG

AAGAACTATT

CATCTCAAAA

GGAGAACAGA

GGTAGCACAA

ATGTGATAAA

AGCTCCGCAC

ATTGAGGGAA

ATATATTTTIT GCAATTTCCT TAATGTCATA AAGTTGATGA TGACAGTTAT GCAAGTATAA AAACAGGAAA GGCAAGCAGT ACAGCTATTC ATCCAGAAAC rcCAAGAGAG AAAATGGATA TTGCACCTTT AATCCCAGCT GCAATGAGCT ATGATTGATT CTGAGAGCGG AGAAGAAACA GAGACTGCTG GCAAACATGG AATCAACAGA CAGAAGTGGG GTGAATCCGT AATTATTTAA GTTTACCTAG TGGATAGCTT GCTCAGAGAA CTTTCCTCCC ACTGAAAACA GGGAAGGGCT ACAGCCTCTT GCGCTAAGAG GATTAATM TAAGAAAAAA ACCTACAAGG CTGAGGTGAG GTGCTATCGC ACTCCAACCT AACAAATCTG ACCAATAACC CCTTJ7GACCT AGCCTGAACT GAGAAAACAA TCGTAGTTCA

TAACTACAAC

CTCATrAAA GAGTGAGCTr T-hTGATAGGC

TACACTGCTA

AAACATAGAC

CCCCACACAG

TACTGAATCA

GTTGACTTCA

AGAGCAAAAA

AGTTTFCCAGT

AAACCTCTTT

ACAACCTAAA

GTAAAAAGGA

AATGGAAAAA

GACTAACCTA

AGTATCTGAG

TATCTTGTGG

AAGCAGATAA ACGAAGGCCA TGGTGAGGGA TGGAAGACAT TGTGATATAT ACTCAACCCA AATTCCAAAC AAAATATATA ATTGAATATG TATTAATGCC TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC ACTCTGTICT ATACU-GCTG TrrTCTCACA GCCAAGGTAC AGAGGGGACT TAGAGGAACT GCAGGAATGT AAAATGAAGC ATCTACTTCA GAAAACCATT TTATCAGTTT CCACCATGCA GCCCAGCCAC TCTACTCCTA AGTATACA CAAGAGAAAT TTGTATTTAA AGGTGATGGT TAGCCTTGTG TGTCAACTTG GCTAGGCTAT AATAGTAATC TAGGTGCATC TGTGAAGGTA 1TITGTAGAT GTGGTTAACA AGTAAAGGAG ATTGCTCTTG ATAGTATGGG TGGGC1TCAT CCAATCAA3T GTAAGGTTTC CCGGAGAGAA AGAAATTCTG CCTCAAGACT GCAGCCTCAA CAGCCAGCCA GCCTAAAGAT TITGCTAGGCA TTATAATCAC ATCAGCTAAT ATATATATTG ATACAATGAA TGGTTATAGC AGCCTrATYI7 GTAATAGCCA TGTCCTTCAA TAAGTGAATA CATAAACAAA TTGTGGTATA TCCACAATITT ATAAATGGY[ GAATAAGGAA TAAACACATA ACAAGGATGA ACCTTAAAAC GTCAGACAAA ACTAATACAT ACTGAATAAT TCCATTTATA TTGAAGTTCT TAGTAACAAA AAGCAGAAAA ATTrrGCCCA CTGGTGATGG AGGGGGCGCA AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACT-rTTG AGGGTGATTG

CAAAGGCAGG

AAAGGAGCTT

CTCCCCATTC

AGAACTCTAA

CTAGAAAGTT

GAAAACGTGT

AATACCCAGT

GCTACAATCT

GAAGGCCTrTA

CTCCTGCCTG

T-FCTTAAAAT

CAAACTGGAA

TTACGCAGCA

CGTAAGGCTG

AGAAAATGAG

GGTATTGTAG

ATATGTTCAT

CATGGTTrTCA TAGGTGCATA CATATGTCAA AACATCAAGT TATACACTTT TAAAATGTTC AGTTTrACTGT ATATCTATTA TACTTCAGTA GAGAGGAAGG AAGAAAGTGG GCAGGGTGGG GGAGAGGAAA GGAAACGAGG GAGGAAAGGC CCTAATAGGA AGGA=iTTG AGTTTAGATT TTAAAATGAT AAAGGATGTT TGACACTCTA GGCATATGAC ATACTITAA GTGAAGGATC CCT-FCTCATC CCAATACTCC TCCTGCATTC CGTGACAAAA TTTTTGGCCA GGTGTGATGA TGAGGTCAGG AG1TCGAGAC AGCTGAGTGT AGTGTGGCAG ACCTGGGAGG TGGAGGTTGC CTCGGTCCCC AAAAAAAAAC CCT-FAGCCTG GGCATCAGAG GTACTTGTCC GCTCACTGGC TTACTCAACT ATATCCAACC GATATTTAAC TGCTCTGCAG TGTGATATTT 'TrGTTGACG TTATTTA'ITA AATGCCAAGT

GAATATAGGA

AGTGGATTAT

TTrCCAAAGCC

TAAGTTTCC

CTCATGCCTG

CAGCCTGGCC

GTACCTGTAA

TGTGAGCAGA

ACATTTT

CTCTATCTAA

CTGTGCCTCT

TCTAAGGCTG

TrCAGGACAT TrATGAGTCC ACAAAAACCA CCAGGAAGTC ATGTATGTTr CAACTCCCTA ATGCYFITGCC TCTCTATGAC TGGCTGCTGT CCTrGCTTAA ATGTAAGCCT TCTTTCCTCC TTTCAACACA TTAAACAGAA TGTACAGCAT ATTTT~GTA CAATTAAAAA TAATCCCAGC AATGGGAG GCCGAGATGT GTGGATTACC AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAATT TCCCAGCTAC TCAGGAAGCT GAGGCAGGAG AATCGCTTGA GATCAGACTA 1TGCATTCTA GGCTAGGAGA CAGAGTGAGA TTAATG'TrTC CTCCTTGCCT GTAGGAAAAA GGCTCTGACT ATGGACTTTA ACCTGATT GTGGCACTAA TTCCATTrGCA CTGCCACTAT T-FTTGGAATA ATGTCCTCTC TCCATCT-rGT TGCTCCTACA AAGCCTCCCC TGGCTACTTC AGCCCACAGA TCTTCTGACT CTTTAAATCA CA1TTACTTA TATATGATCT TGTTTACTTT AATfTTTCTTC CATAACCTAT TCA1TCAACA AACTCAACAA TAGAAAAATA TTATTGATTT TATATAGATT ATAGATATGT TTGAAATT'TT 182 AFFTGGCAAT CTGCAAGTAG AAAAATAATT ATAATGTGGT CCATGGGGAA CATAATCCAG CCTGGAAGTT CAGGAGAGAT CCTACAGGCA TGGAAGAAAC ATTAAAAAAA ATTTTTTTT CTAGACTGTG GTGGTGCGAT CTCTGCTCAC TGCAACCTCT CAGCTTCCCA AGTAGCTGGG ATTACAGGTA CCTGCCACAC ATATCTGTGA TAGAAGTATT AGTGCAGAGA ACGTGGAAGA AAGGACGTCA GAGCCTTTTT TTGAGATGGA GTCTCACTCT GTCTCCCAGC GTCTCCCGGG TTCAAGTGAT TCTCCTGCCT ATGGATGATA AATATGATCA TATTT-rCTTG T-rCTTTTCCT CCTCAGTTGT CTTCCCTGAA GAAAGGAATG CCT1TTATAG ATGACAAACT CCCATTCTCA AGAACAAGGA TTTTTGACCA ATAATTTA ATCAGATGTC TGGCTTTGAC CTAGAAACAC AGTCACGAAA CTTGGTGATT AGAGACCAAT TCCCAAACAT GAGCATTTCT TAGGAAACAC AGTAAAGATC TGAGAGACCC AAGAGCAGAA GGGCGAGAAA CCAAAAGCCA TCAGTTTGCA TAGGAAACAC CTTGTTTAGC CTAATCTTT TATTTTTATT ACTCTATTAG TCACTACAAC TATTTJTCTGA TTGCTATGGT GATAGATGGT TrAAAACAAG CC'ITCATTAA GAATTGTCAC ACCATGGTCT CAGTCAAAAA CACCAACATT TTTATTGGTA TTGACAATTA TGGGAATATC CAATTCCAAG AAGACAAGGA GACCTCTGAA CTTTCTAAAT GAAGACTCCA ATCTTCCTGA TCTGATGGGA AGCAGCTTGG CAAGATTACC AACCACCACC ACAGAGAGTG GACTCTAAGC TAAGACTTAA AAGATAAGTA GAAATTATCC AGGTAAAGAT GTGTACAGAG AAGGAAGTAC ATCCAGGGGA AAAGAACAAT ACGTGCAAAA GTACGGAAAT GGTAAAAAGT AATACTACAT AGTCAAAGCC AAGCAGAGTT CAGAAGGGAT CTGGTGGTGA AAAATACGGC TAGAGAAAGC AGCAAGGATT GGCTTCTAAA ACCTATGTAG TATCTTGGAC CT-fACCCTAA ATGTAATGAG AAGCTTCTAA AGAATCTTTC ATTJ7ATTCAT TCATrGAACA AATATTrTGA GGCTTTCTGT GAAGAACATC ATTCTAAGTA GTAAAGATAC AGCAGTGAAT AGGACACATA AAATCCTAGA TCTCACAGAA TTGACATTCC AGAGAGGGAA AGGTAGACAA TAAATACATA AACAAATCAT TTAACAAGAT

GATY-FCAGAC

GAAGCCTGCT

GAAGGATACC

TGCCCTTGGG

ACAGAGGAAA

GTCATAATAA

GAGGTGTGAT

TAGGGGCTAT

ATAAAAGTGG

AAAAAAAGAA

ATTGAGATAA

CCCAGTGGAG

CCTGTGATCC

GGGCAACATG

TGGTCCAAGC

CAAGATCTCG

AATGGTACGT

TACCTTJ7GCA ACTGTGAAAA AAATGAAACA AGGTAATGGA CAGCGAAAAG GCACTGGAAG TGGTTAGAAA AGATCTCTCT AAGAAAGAGA GAGAAGCTAG GTGTGCAAAG ATGTGGGGAC AGAACTTTTG TGCAAGCTTT GCCTGTTCAA GGACCAAAAA GAAGGCCAGT ACACTGTTAT ATGCTGAGAT TGGAATTATA AGTAGAGCCA GGCAACCAGA TTTTATTCCA AGAGGATTTA AAAATCACTG ITGTATTT1TT AAAAGATAAT TCTGGAGAAT TAACTATAAT TTCAGTGGCT CAGACAAGAG ATAATGGTAG CTTAGACTAG CACTCTACT7 TGGGGGTAGA GTCTATAATA GGTrTGGTrT AATAAATTAA TAATGGTTCC TAGGTTTGTA CCTGAGCAAC AGGAGATTGA GAATCACAGG CTTrTGTTTTG CAAATTAATT AYJ7TCAGGTG AGTGGAGCCC ATTGAAAGGT AAGGGACAGG CAGGACTTTG GAAGGCCAAG GCAGACAGAT CAGTTGAGCT GGAAAACCCT GTCTCTACAA AATATGCAAA ATATTACCTG CACTTGGGGG GCTGAGATGG GAGGATCACT TGAGTACAGG CCACTGCAAA CCAGCTITAGG TGACAGAGTG AGAACCTGTC CCACATGTGA GCTGCGACCT GACTGAATAG CAAATACAAA GTGCCTGCAG CATACTAAGC GATAATATAG TCTCTTATAG GAGGTTTTGC ACTAGGGTGA GAGGTAGGAG TAAACTAAGT GATAGTAGTC GTAGAAATAA ATGGATCATA TATGAGAGTA TGAATAAATG GGTGCTGTGA TTGAGAGGCT TATTAGACAT GTCAGGTGTG GTAGGTCAGG CAGGAGTTTG AGACCAGCCT GGCATGGTGG CATATGACTG AGGCGGAGGT TGCAGTGAGC TCAATAAATA AATAAGAAAC GTAAGGGAAA AGGAAATITAA TCTGATCATT GGCAAATGCA TAGTATTTAA AGCCAGGGGA GTAGATGAGA TACTCAAAGT AGGTGAAGAT AAGGAGGCAA TGAAGGCCTA GGACTCTGGT GTACATTrAG ATGG1TATAA GAGGAATAGA AACTGGCAAA ATAAGTAACA CTGAGCACCC AATGAGGTGG AGAGGAAAGC CAGGAGATGA AGCATCATAG AAGGCAAGAG AAGAAGGGTG

TAATATAAGG

AGAAGACCAA

TCTTGAGAGA

GTAAATAGTT

TAGCTAATGT

GGATGGATGG

ACTGGTAGCA

ACAGGAAAGT

GATCACTGAT

AAATTATTrTC

GGGTTCTTAG

TAGGCAACAG

AATAGCTTTC

TACC11TACCT

TGGGGAATTG

AGGAAATACC

GGGAAAATGT

ATAGGCACCA

'TTATATTGT

GCAGGCTCTC

AGTCCCCTGG

TTrTGTTCATT CTrCTI7CTCT ACAGTATT17A

GTGTAGCACA

ACAGAAAAGT

TTAGAGTAGA

CTTTJ7CTGTG

TGAGATCAGG

GCAC11TAAGT

ATGGATGGAT

GAAATAAAAA

AAGACATTAG

ATTGGACATG

CCGTTCAGGA

GATTrFACTGT

TGGAAAGACA

AGTGACTAAC

TTCGACCCCG

CTGTATACTT

CTCAACTGAA

GACCATTGGA

YI7GAGGAGAT

AAAGGAAACA

GATAGTATTT

ATGTTCTCAA

GGAAGGATGG

CAGCACTGGA

AAGAGTCCTT

TTCCTAGTGA

CAGAAAAACA

TCAAAGAGGC GAGGCAGTCA TCAACTTCTG GGCAGTCAAA TTTGGAAATA TGATGAGCAC TTGAGTGGA GTGTTGAGAC AACGAGAAAT GAGAAAATGT AACCTGCAAG CACAGACAAT GACACAGAGT CTTAGCATGT C17GTCTTTC TATGGGAAAT TATrCTGCTT TTTGTACCTC TACATTACCT AGCATAGAGC TTCTTATCGC CTGAATGACT GGATGGGTGA AAGAATGGAT ATGGATGGAT GGAAGACTTC TGA'TrGCCA AGAAGAGGAT GAAAGAAGAG TTTAGATTTT TATFTCTTTGG TGTCAGTTAG AGATAATTTA TGTAATTGTT

AGCATTTTTG

GAAAACTTGA

TCCCAAAACT CTGTCAAGAA ATTCTCAGAG AAGATTTG11' ATGGTAAGAC ACAGGGTGTT TGTTCCTGAA AYITGTTAAAT AGCAAACTTA CAATGGACAT AATGAGAGAT CATCATGC GTG17TCACT

AGCTCCTATT

CAAGAAAATG

TrrAAGAAGAC

AGCTCTTTCC

TCATAAACTT

ATTTATAAGC

AAATGAGTTC

CATGCAAGCA AAATTAATCT 'rrGAAATCCT CC=T'CCAT CACTTAGGAT TTTTAAATGT GGTJ7GAAGTT AATAACTGTA AGAAAGTTCA AGATTCTCTG ACCTGTATAC T1TAACTGGTC ACTI7TCCATA GGAATCAAAC TrCCAACCTC ATGGCTGTTG ACCAAGGACT AACCAGCCTC CATAATGATA ACTGACTAAT CCT-rGCCCAG GCAACTACTG TITTTTGTGTC 'ITCCT1TCC AAAGTGATTT GATAAACTGA GAATGCTGTC TGGCCCAACA GTATGAACAG TAGGTTTCTG TCCCTACTCT TACTrCCCAG YTATCTAAT AATGTGTTAC GAGATTGTGG CTCTCTA'1rA TAGGGACTGG AACCTAGTAA GTTATGAT CCCAATTTTr ATGCAAT117C TAAGATACAG ACATTGCTTC CCTAGGTGAG

GAAATATCAT

GTCCAAATGT

GACTTCAT

AATTA'FFCCA

CATGGCACCA

TAAAAAGTAC

TTCAACAAAC

TATTA'TrCA GGTGCCTGGA TCTCATCTCT ACAGAAAAAA GATTGTATTT TCAAAGATAA CCTAAGGGGA

CAGACACTGT

'TrATGTAGC

GGTTGCAGAT

AAGGGACAAA

ATTTATTGAG

YT-AATCCTC

GGCCAATGGC

CACCTCCATG

TAAAATTTGC

TGCTCATGGT

CATTTATATG

ACAACAAACC

TGGGAAACAG

ACAGGAAGCC

TCAGTGACCT

ATACT1IAG

TGCATCATGC

CATGAGGTTG

GTTCAAGGTC

CTGCTACTCC

CAGAAGAAGA AACTGATATr CAGAACCAGT TAACTAACTG AACCAAGAGT CAAAGACATG ATYT-AAACC AAAGCTTTTr ATCTGAGGCA T-rCCGCGAAA AGAGAAGGGT CATAAAGCCA AGOGAAGACA AGCTTAGGAA AAAAAAGGGA 183 AATGTCCTAA ATAAACAGCT YTCCTATTTA CCAGAAACCA CTAGTTTAAA AATATAATGG GAAAAATCCT ATTCACTTfA ACAATGTTAA AAAAAAAAAA

ATATGTAAAG

ACCATCTTAC

AATACAATGT

AAATATAAGC

ACAGAAATCA

ITAATACTAG

AAACTAAAAG ATGTTAATAA TGGATTCTAA TATTTAATAG CAAACGAAAT ATCT[AGGAA ATATATGAAG AGTGAATGGG AGGAGAGTCT TGCCTGCCAG TGTAGCAATA GGCAGCAAAG TGATGAAGAT TTAAGGTATG GACAAATAGC TAATCA11TAG TACATTAAAA TAAATTCCAG GAAAATATAA GTTGTTATAT TCACCTAGCC TAGAGTGCAA CTCCCAGCTC AGCCCCCCAG TrGTAGAGA CAGGGGTCTU TCCCAAAGAG CTGGGCTGAT AATACTAATT TTTAAAACTA YTGTAGCAC TTATGACAAA ACAATGAATA CTCCCAATGG TATGCATATA TGTATGTGAA

ATAAACATGA

AGGGGAGGAA

ATGTATTACA

AGTCTTYI7GA

TGGCATGATC

GTAGCAGGAA

GCY7TGYTTC GGGACATTrT GATAGAAGAA ACATAGGGAT AAACTfAACA CATTTGTAGG TGGCCTAAAG AAAAAAAAAC TTACATGTAT GGGGAGATAG TCTAGGTGTT CCATTTCTCA CCAAATTAAT GTATACATT[ TTGCTTACAA ATTGTCAGAT AATTACAAAG TTTACCTGGG ACCCCACCAC TCCCCCCAAA ACAAAAAAGG TCTGAAAAGG ATACAAAATT CTATTATAAA GGTGTATTGA TGAAAACAAT CAATGAAACA GCATAAAAAG ACCAGAACTA TACCTAATTA CATAATTCAA ATCAGCAGAA ATTGGCATAG ATAGGGTTAA GGAAAGGAGG GAGGATAAAA TTAGGTTCCT GCCTrCATCT TTTAAATTTT TTTAAAAAAA GAAACCACAA AATACTTGAA TGGGAATTTT TTTTTTTTTC AGAGACAGOG TCTTGCTCTG ATGGCTCACT GCAGCCTTGA ACTCCTGGGC TCAAGTGATC CTACAGGCAT GCGACACCCC ATCCAACTTA TTT1TrATFT CCAGGCTTAT CTCGAAC'rrC TGCC17CAAG CACCTCAGCC TTAACATAGT GCCACATTAC CATAAATGAA AAGCTTGTAA ATATATATCA GAAATTTTTA TAAACAAAGT TAAAAAGCAA ACACAAAAAA

TAAGGAAATA

AAAAAAAAAT

CCAGGCACGG

AGGAGTTTGA

CATGTTGGCG

GTGGAGGTTG

CAAAAAATAA

GCATGTGTAC

GAAAATGCTT

ATTATTTATT

CGTGAGGAGA

TTAAAGAAG

CTACCCTT

CTTATCAAAC

TCTATATCTC

CTAGAAATAT

AATTTFTCTTT I

ACTGCAGCTT

TGTGCCACCA

CTGGTCTGCT

CAATATCTGG

GCTAGGGCTT

AGAGCCACCA

ATACAGGAAA

CATCCTGATC

T-rCT-rATGAA

GCTAATCCTC

AGCTCAAGGC

TGATGCTACA

TCCCACTATC

TGCTCCCTT

ACAGTATGCC

CTCTTCATAC

GAGAAAATAG

C'ITTGCATTT

T-rCAGT1TG GCCTTT-rCCC

CATACACCTA

TGGCTCATGC

GACCATCCTG

TATGCTGGTA

CAGTGAGCTG

TAATAAATAA

AAGGGTT'FAC

TAAAAATATA

TATATGTATA TATATGAATA CAAAAAGAGC AGTATTCAAA ACTAAACTGC TAAAAGCAAT AAAGTAAC CTTATCAAAG AAGTAAACTC ACAAATAACC AAAATCTGTA AGAATACTGA GTTCGGCATG TAATTAATAT AGATCAGAAC CTATAATCCC AGCACTTTGG GAGGCCAAGG ACCAACATGG TGAAACCCTG TCTCTACTAA ATCCTGGCTA CTCGGGAGGC TGAGGCAGGA ACATTGTGCC ACTGTACTCC AGCCTGGGCA C1TFACAAAA

TCAAAACAAA

TCAAAGAAAT

GCTGCGAATG

ACTTfTAAAAA

CGGGTGGATC

AAATACAAAA

GAATTGCTTG

ACAAGAGCAA

AAATAAAATA

ACACAAGAAT

GATTAAGACT

T7TATATACT GCCTATrGCA

GTACATTGTG

CTGACCCATC AAT~rGTCCA ATATTGCTrT TAATGCTAAA GTACAGTCAT ATAATCAATA TAACAACATT CTGTTAGGAT CTGCTCCTTT GCTAATAACC CCCTTAAGAC TCTCTGTTAC

CAGTAAGAAA

AAACATAAAC

AAACATCAAA

TTTCAGAAAA

TATTrATAGG

ACCTGAAGTC

ACTAGCCAGG

AACCCAGGAG

AACTCTGTCT

GCATAATTAG

AAAAATTGGG

GTATACAGCT

ACGCAAGCAC

TTCAATGGCT

TYFAGCTCAAA

TCAGCCTTTC

TTTAGCATTT

CTCTGAACTG

ACTCAATAAA

ATCACAACTC

ACTACAGGCA

GTTACCCAGG

TTCAGCCACT GTCCAAAATA TAGCCTGGCC TCAGCTATAA AGTATCAGTG TTTCACACCA TAAAAAACAA AGGCAAAAT[ CCTTAGTCAG CAACAACACT GCCCTAACCA CTTCCTrTAA ATAAGTATCT CAGGCCTACC TCTATAAAGC TTfTCTCTCA TrGGCCATTT [TTTGAGACA AGGTCTI7ACT CTACCTCCCA GCTCAACAGT TACCCCACTA CT-FTTCATTT GATCTCAATT GATCCTCCCA GGATGAG1TTY

TCTCCAGGAC

CTGTCCTAAC

AGGTAAAAAG

TTGCCCCCC

CACTTrCACT-r

CACTCAAACC

GTTTACTG

TGGAGTACAT

TCTTCCCCAA

CTAGCYTTT

TTr1ATTACCT

AAGTGGTGTG

AGTAGCTGTG

ATCTCACTAT

CTGTCGCCTA GAATGGGGGG CCTCCCACCT CAGCCTAGTG 'I17TATTTTTT GTGAGATGGA CTGTGGCCTC CCAAAATGCT GGGATTACAG GCATGAGCCA

CCCCAGTAAG

TGCATGGAGT

AAAACAGATA

CCACAAAACA

CAAGTTAGCA

GGCTGTCTTG

CACCTCAGGC

CCCAGCGTTG

GAGGAGTTGC

TGCCTACTCT

k.GATTTAAAC

TGTCAGTCAT

TACTAYI7ATC

AAGCCATCAA

CCTCTCATfrA AATAYI7ATCA kTCAAG'rr rATCATCAC

TGGCAATCAT

CTTTTAAGGC CATTAACATG AGGAACAGTG AGGAGTTTAG TAAATGCGGT TGATGGGTTA TTATGTCTAT TCTCATCAAC AATCAAAATT TTGAATGGTG ACATTAAAAA ATTCCCCCAG AACTGCAAAA GATAGGAAGC ACTAATGAGT ACTGGATCAC A1T=TATTG CTGTTGGAGG AACACACAGT CAAGGATCCT ACCAAGTGTT TFTCCCTTGCA CTAGGGAAAA GACATATTCC TGAACTTTGT GTCA'ITAATC TCTCTTCGT-F TTCMTACAC TATTrTATCA ATCAATGTGT GAAAATATTC GAGTAAACAG CCATTTTCTA CAGGAGCCAA CCAATTTTTT GGAAATTTGA GTAGAAGCAT TGCCAAATGT GTGTGTAT ACCGTCAAGT GTCTGTTGGC AGGTACAAGT ACTCCCACT[ AGATCCCAAC CCTGTTTAAA GGAGAAAATC TACAAAGCCT TrCAAGCGGG CCCTTrATGCG TGCTCCATAC CC'FrCCCTCT ATCTFTGTTTC CTATTTCTCT

ATTCTTCC

TTTTCAATGC

CCAGTTAGAA

GGGTCTTCAC

AGGiTCTCCGT

ACTACATTTC

TCTTCCCCCC

AAGAGAGTT

CCATGGATGT

GCTCTrACCA Cc'rrrcTC

TGGCCATCAG

TAAAAAGTCA

GACTGTAAAC

CATTTGACCC

ATGCACACGI

ATGATAGACT

AGT-rCATGTC

AAAAACCAA.

CAA'rrTACTA

TTAAATTTAG

CTCAATTCCA

TCCCTCATTT

CACTTTTACA CTGTTGGTGG GGATCTAGAA TTAGAAATAC CAATGCTGCT ATAAAGACAC ACCAACCCAA ACGTCCAACA TGCAGCCATA AAAAATGATG AGCAAACTAT CACAAGOACA GAACACTTGG ACACAGGAAG ATAGCATTAG GAGATATACC

GATCATAGTT

AATTGCTAAC

TTCATGTGAC

TTAACTGATG

T CCACAAACTC CTACTGCC'rr ATCTAGCCCT GTACCATATA ACTGCCTATC TGTGCTrCTA TCTAAGGCTA ACCCTTCCAC ACTCAAGGCC ATTGCTCTAG CAATTCTCTC AT-rCTCTCTC AATTAACAGA GTAGCTCCTA AAGGGAAAAA AAAGTCTTCT AGAAATGCAA ATCAAAACCA CAATGAGATA TCATCTCACA GGAAACAACA GGTGCTGGAG AGGATGTGGA GAAATAGGAA TAGTTCAACC ATTGTGGAAG ACAGTGTGGC GATTCCTCAG *AGCCATCCCA TTACTGGGTA TATACCCAAA GGATFTATAAA FATGTITATG TGGCACTACT CACAATAGCA AAGACTTGGA GGATTAAGAA AATGTGGCAC ATATACACCA TGGAATACTA *CTTTGTAGGG ACATGGAGGA AGCTGGAAAC CATCACTCTC SCACTGCATGT TCTCACTCAT AGGTGGGAAT TGAACAATGA GGGAACATCA CCCACTGGGG CCTGTTGTGG GATGAGGGGA GTGGGGAGGG TAATGT~rAAA TGATGAGTrA ATGGGTGCAG CACACCAACA TAGCACATGT 184

ATACATATGT

ATATATATAT

CTGTGTTTTA

TCAGTTCTCC

CTCCCTCAGT

CTCCCYT-

CTCCAACCTC

ATGCACCACC

CAGAGTCTCA

TGGGTTCAAG

GCTAATTTTT

CCTCAAATGA

ATT-rTGTGTT

TGATCCGCTC

TGCCCTT7GT

CTACGGCATT

CYTTTACCT

CTATTCAATG

AATAATYTTC

TTGGCAGCCC

AAATACAGTT

CGTCTACGAG

TAAACAACAA

AGAACTAATC

CTGTAATTAG

AATCCAGGGG

CTAAAAGAAT

GCGTCTAGAA

TGGGAGCACT

AATAACAATA

GAAAAATGGT

ATACAACCCC

ACCCCATAGT

TCAAGTTTCC

GGATGGCTAT

GTTTTTTATT

TAAATGTGCC

CCCTCCCCCA

TGTTTATGTG

ACAAGAAACA

GTGGGCTTAA

TTrGAGATGG

TGCCACCTGG

GTCTCCGGCT

CCTGACCTCA

GCCCACAGGT

TGCTAAACTG

ATAGGTAAGA

AAGCCCCTCA

GTTITGGCCA

TCAGGCACAA

AGCAGAGAGC

AATGGCCCTG

TTTTTACTGA

TCTTGCTCTG

TCAAGCGAT[

TTGTATT

ATCCGCCCAC

TACCGTCTAT

CTCCTTATCT

GCCAATCAGA

GGACTGAACC

ATAACATCAA

CTfGGTCACT

CACAGGAAAA

TACAGTTCAG

GGACCTATTG

AACAAACCTG CACGTTGTGC ACATGTACCC TAAAACTTAA AAAACAACTA AAAATAAATC T-rCTTTCT 6CAGGATCAG TGT-rGTTCCC CAGCTTAAGA GATCGTTCTC CAGATCCCAC ACTTCTT1Tf GCTGATAAAC TACTCTAACT AGTTACATAT TGT1TGAAC ATAATCATTT ATATCATTTA TCA'n=CAC 1TTTAGATGG AGTCTCACTC TGTCACCTAG GCTGGAGTGC CGCCTCACGG GTITCAAGTGA TCCCCCTGCC ITAGCCTCCT ACACCTGGCT AATTGCTTTG TTTTGTT"TG TGTGTGTGTG CTCTGTTGCC CAGGCTAGAC TGCAGTGGCA TGATCTCAGC CGATfCTCCT GCCTCAGCCT CCCGAGTAGC TGGGACTACA TTGTATT17C AGTAGAGACC AGGTTTCACC ATGTTGGTCA TCTGCGCACC TGGACCTCCC AAAGTGCTGG GA17ACAGAC TITAGTAAAG ACGGGGTTTC ACCATGTTGT CCAGOCTGGT GCCTCAGGCC CTCAAAGTGC TGGGATTACA GGAGTGAGCC TAATATGACT GTTGGCCTGC ACATTGTCAA ATCCAGTGGC AGTATAATAA AAAAATATAT TCCATCACCA CACACACAGG TGCTCCTTCC AG11TGTCACC GATTTCTGTC CCCAGGTCCC TCTAAT'TGCA CAACCAAAAA AGTGGCATGA TCTCGGCTCA GAATAGCTGG GATTATACAC TGTTTT[TT TT1TTTTGGA TCACTGCAAC CTCCACCTCC GGCATGCACC ACCATGCCAG GGCTGGTCTT GAACTCCTGA TTGAGCTACT GCGCCGGGCT CTCAAACTCC TGACCTCAAG ACCATGCCTG GCCATAAAAC ATTCATCTFA CTCGGCCAAC CAGTATACTG GCCTGGCTTT TGAAGGTATG TTGCATTrTG AGTTCCTT[rA CTAGGATAAA CTGTGTAATC TTTGTATTCC ACATT[GCAC TGGTATAACC ATTTCTGTAA GAGACTGAGA AGGTAGATTT GAATYI7CAGA CTGGCAATTC TACCTGGTAC GTGATGGAAG GGAGGTATTT CTGCAATGAA CACACGACAG TGACACTGTC TGTCTITCCT CTT1fATATG CTCTTCCAGT AATAATGACA AGTAATGATC TTCCCAACAT GGGGCATATT C1TrATATC AGTTCATCTA GAACTT-rTGG C'1rGACTCTTF TAGGTT1TUC AGAATTAGTA ATACTTTTT AGTATGTCTA CATTCTCTTG AAAGATCT-rG AGTCACTGTC TTCCTCCCAG GGATGAAGAT GGGTGCTTTG GTGATCTAAA AAAGAAAGCA GCTGTGCCCT GTGGGAAGTG

TCTGTTCCTC

CTCAGGCTCC

ACTI7AAGACA CCATTrTCCAG

CTGTGCAGGA

AGCTGAACTC

AACATAAATC

CTGAAATATFr

ACTCTGTAAT

TATCTGTTTC

ITrTGGGGATT

TTAAGTGGTC

TCTGACTGTT

AATTGGACAA

ACCAAAAATA

AAGGATACAC

TGTATCTTAT

AAGTlCT1TG TTTTTTATCC TGGCCCAGAT CAGGAAAAAA AAATTAAAAA CATCTGAAAA AGCTTTTGTA GGAGAACTTT CTGTCTGCAC TTTACATCAG AACAACCTTG GTGGTGCTrG GTAAGAGATG CCAGGACCAG TGGTACCCAC GCCAATACCC AGCAAGGAGC ATGGGTGCAC AGTAAGGCAT AGGGAACGTC ACGGAGAAAA GGCCAGACTT CCTTG1TA AGTAAAAAAG CATGCTJ7GGA TGGTCCACTC CAGGCAAAAC TGCATCATAT GTTTGTTTCT GTTGGGCTGA CATGAGGTTC CTCCTGGAAA TACAGCCAGG TCAAGAGAGC TCCACATAAA ACTGATCAGC TT7CACAAC TCTTATCCTT TCACTAACTT TTGAGGGCTA YU7TCTGCGCT TTAGTTCAAT GTT-GTTCT ATATTTACAC TITTAAGTTCT AGGGTACATG TGCACAACGT ATGTTGGTTT GCTGCACCCA TCAACTCGTC ATTTACATTA GTCCCCCACC CCCCGACAGG CCCTGGTGTG TGATGTTCCC ATAGATTACG TrATTGATT TGTGTATGTT GAACCAGCCT AACACTTCAC AGATGGATCA TTATGTGTGA TAAGTGAAAT CAGGTAGGAA GAOCAGTATT TTCCTTCAAC CATGAGTGTA AGTCTCACTC ITITTACCCAG GCTGGCGCGC AGTGGTGCGA GTTCAAGCAA TFTCTCCTGCC TCAGCCTCCC AAGTGGCTGG AATTTTTGTC TTTAGTAG AGATGGGGTT TCACCATCTT TGAATCATCC TfCTCAGCCT CCCAAAGTGC TGGGATTACA TTTTCAAAGA CTAAACTTAA AAAAAAAAAA AAAATTTCCC TGATAGACTG TTTTACAAGA ATGCCAGTTT TCACAAGTGT TGAAATITTG ATAATATTTG ATGGCAAAUT TAAACAGGTA ACCAACTGAA TGGACTCCTT CTCTCAGCCA AAGGAATACC GGATTGGGGG TAGGTGGGGG AAGCCCAACA TGACTCATTA CTGAATGTCA GCATrGACAC TAAAACACAG ATCTrAAGAC CAGGCCCTGG AAGAAATCAA GYTATTTrAT CCCAAAAAAM CAAAGCTGTC TCTTGTGGGG AAAATTGACA TGCTGTACAG TCCAGGAGAG ATI'TAACTAA GAGGCTAGCA TGTTTTT TTGCCCAGGC TGGAGTGCAG TGGCGTGATC TCAGCTCACT CTCCTGCCTC AGCTTCCCGA GTAGCTGGGA TTACAGATCC TITGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTAGT CTCGGCCTCC CAAAGTGCTG GCATTACAGG CGTGAGCCAC TCTCTCTGAA GCTACTATCT AGAGGCTTCA TCAACATAAT TATCCTA17A GTrTCTACTG A17CCAGGTC TTTAGATAAT AAGTCTTrGA ATCCACCTAT GACTTAAAAG CCCCACTCCT AATGTACACC TrATATGTGT TGATGGATAT CTGCCTGTAA GCTGTAACCC AACCACC11TG GGCACATGTT~ TTCAGGAACT CATA'T7GGC TCACAGTAAA CTTCTTTAAA TATT1GTATAG ATAAAGAATT GGAAGGTCTT TCATCAGTCA CTGAGCCAGC TGATTTGTAG CT~rTGCTACT TAGATTOCTA TCCATTATCT GAAATGCAGA CTCCTCCT AGAACCCAGG ACCTTGGAAT 185 TGCACTGTGA TrCAGCATAA GAATGTGGGA AATGTCTTCT TGACTAATCG GGGGTCAGGG ACTGTGACCA CTGTGGMTA ACATAATCAA AAAAATAAAC TGGAGCAAGA TTTGAGAATT TTCTTI7ATTA GAGAACTATG GCAGATTTGT TACACAGGTA GGTATT'TCTC CTAATGCTAT CTTlCCTGTGT CCAAGTGTTC TGCATCACAG TCACTTGCTT CCAAGGATTT ATGCTCAGAG TGCAGGT-TT TCTTTTCTTT

TCTTGGCTCA

GATTACAGGC

GGCCAGCCT-r

GGCATGAGCC

AATGAAATAT

CTATAGAACA

TACAACAAAA

AAAGTAAACC

TTCTCTCCTC

TGACAAGCCA

ATT[CTTTGA

AATTTCCTJ7C TTTTrTTT-rT GCAACCTrCG

ATGCCACTAT

ATTGAACTCC

CGTGCCCAGC

AAGACCCTTG

AACAACTCYTT

TCAAGTTATC

CTITCCATTCC

CATGAGACTG

AGTTTGGCTT

TTfCATATCTG

CTGTAACCTC

ACCTGCCACT

GTCTTGAACT

ACTGCGCCCA

AAAACTAAAG

TGTAAT[-AG

ATAAAATTCT

TGAAAAACTA

CC'FrTGGAAT

GACTCTTTGT

TATATTTTCA

TCTTTCCAAG

TGAGGCGGAG

CCTCCCGGGT

GCCCAGCTAA

TGACCTCGTG

ACAAGACATT

GTCTCCACAA

TCAACCAATT

CCGCCMrCT

CCTAAAATGT

TGTTGCAGAC

TTTTFCATTGA

ACTGAGGTCA

AGAAGCATCA GGATCACGTG ATI7CTTGGCA CATAGTAGGT

GCTCAATACA

GTAGTGCT

TCCCCTATTA

CTTCCCTCAC

GTCTTYFTCA

AAATTGCTGG

ATA1TTTCT

AGAGACCATC

GTTTTCCTAG

TGGTTTATAC

GGATATAGTC

CACCAGAGGT

AACTAGAT

T"TGTTTTAAA

AAGCTGACCA

AGTGGAGTGG

CTCCCACATA

GGGTCACCCT

AAAATGCTGG

TGT-rATATCA

TCAGCAGTGT

CTGTCATCAA

CCAGCAATCT

TCCCTGATTG

AATTTrTAATT ATY[TGTTrG

AAACTCTCAG

AAGTCCCCTG

CAGGGTCTT7

TGTTGAGTTA

TATTGAACTC

TTTTCACAGA

GTCTGATTAA

TGGCCCAAAG

TATTAGUfGT

CCTTFGGGGT

TACGAGATTT

TGTTCTCTCA

CTCTTTGATC

TGAGAAATAT

TTACTCTATA

TCACTTGTGT

TCTATTTTCA

ATCATGACTC

CTAGGTGCAA

CTAGTCTTrC

AATCTGCTTA

GAATTTCTCC

TFTTCATATA

TGGCAATGGA

ATGTTGCTCA

CTGTCAGGAA

AACTTTCAAA

TTCATTAATT CATGAATTAA TGCCTCT-AA GCACTCAGCT CATGTGAGTC TGAGATCAAG TCTATTTTAG CACTGTCCCA TATGTTATTA AGGAAACTAG

TGAATTAACA

CACCACGCTT

TGTTATCTCT

GTI'GACTTGT

TCATTTCCCC

CGCTCTCAAA

CCAGTCTCAC

TCTGAGAAGT

CATTATTCTA

TAATAGAACA

GGGGAGGCTC

TCTTTAGCCT

CTGTCTCAAT

GTT11TACTTC TTCTTGAAAA GGGGGAAGAG TG'FrCTCCTA TTAGTCCCCC ATTGCCTGCC TACAGTTGGC TCTTGAAGTT CAGAGTCAAA AAAGAAGCAA CCACTCATAC TCTTCCTCTT GCTCAAAAGG ATGACCCTAT ATTTCCACCC TAGAATGGAA CACCCAGTGC TTGACACATG ACTCAACAAA GTTATAAGAA TAATCAACAC ACCTAYITATC CATGACCACG GTTCACTGCA GCTGAGCCCA CAGGTGTGTG ATGTTGCCCA AGCTGGTCTT GATCTCAGGC AAGAGCCACC GATGCATACT TCAGCACTAT TGTTCCACAG TCCCAAACTC4 GGGCCTCTCC TfGCACTCTT CCCACAGTCA CTTGTAAA CCTGGTCTTC TTCCTTGGGC CATGCAA'TC CATATGTGTT TCTGTTTGCT TGCTfGC~rG TTACCTGTTG TTCTGTTTCC ACTAACAAAG GAAATGCACA TCTGTTCATC ACTCAGCTTT T CTATACAACA CAAGAGTAAA

AT-TTGC

GGTTTGAACT

CCACCATGTC

GAACTCCTTrG

ATGCCTGGCC

CTCAAGCAAA

CAACTGAGGT

GCCAACCCTG

AGTTCACAAG

TCTACCAT-TT

TCTCTATCAT

CTTTAATACA

CGTTAGTUAA

AGTCACAGTA

CATTTGAAAA

CAACTTT1CT1'

CAGAAACCTG

GCTCTACAAA

AM~GAAGTT

TAAGAATAGT

GACAGGTTCT

TCCAGGCTCA

CAGCTAACTT

GCTAGAGAGA

ATAATCAATA

CTGGGGTGTG

CAAATGTAGG

TTrTCTTGATT

TATTGTGTGA

TT1TCCCCA

TCTTCATCTC

TTTCTCTT-rT

TCTCCGAACC

AAAGGGGCAC

TTTACTAAGT

CCATATACAC

CACAGTATGT

AGCACAGAAT

AATA'T[rATT

GTTACAGAAT

CGCTGTCTCA

AGCAATCCTC

TTTAATTCT7

TCCTCCCTCC

CAC1TTTAAG

GGTTATTCTA

GTGCAGCAAG

GTCTCTACCA

ATTGCAGGCA

GCACTCTTTC

TTTCCTCTCC

TCTGAGAAGG

TTCATAAATT

ACACAGAACA

CACCAGGAGA

CCTATTACAG

AAAACATTCT

GTATCATTTT

TATCAAGTGA

TGGTATACAC

CCCTGGCTGG

CCACCTCAGC

TGTAGAGACA

AAGGTCCCCC

AATGCTAGAA

CATATAAAGT

GTCACTGGGG

CCATGAGTCA

ACCCCTTGAC

TGCTGCTCTA

CTITCCATCCA

CTTGAGTCCA

AAATCTGACA

CAAATAGACC

TATAGGAGA TCCAGGAGAA ATGAAGTGGA AAGGGAAGTG CTTrCTTATA AGTGGTAAY[ TIT=TTACA GGAATAATTG AAAATGGAAA TTACCTTCTC AGCTTTAGTG TAAGGCAGAA CATGTAGGAA GTGGCACCTG CTTGTGTACA TGTrFGAGATG

TACTCATAGT

T-FCTGTTrAG

GGAGGGTCTC

GGAGAGTTCT

AAGTACTCAG TGCGTTCTTG ATGGGATGAG AATGTGTTTG TCTGCCAGTA TTGGAGAAAA ATAAAACACA AAGGGACTGA

CTGCTGCGCC

GGCGAGCTCT

GTGGGCATGT

ACCATGAGCT CAAACCCCTC TTGGGCTCTG GCCCCGTGGT GTTACAGTGC ACTCTTTCAG AATrCTTCCT ATrACAAAAA CTGGCCCCCC TCGCAGGATG ATAGGAGGGG GAGCACACAG ACTGTCTAGA GGTGGGTGCC CTTTGCTGTC TGCAGCTTAA TTCTrGGTAC CCAGGTCCTT GTCTGGCATC CAGGAAGAAT CAGGTTACAC

TGCCCCAGAG

TGTGACAGTG

GCAGGAAGGT

TGCAACTCCT

GCGTTAACCA

ATGGACTTGA

GCTGGAAGGG

CCAGTCGTCC

TCATCTGCCT

CCAAAAGGGA

TTGAAGGTGG

TGGGCTGATC

AAATAAAAAG

GGGTGGCTCT

GCAGGAGCTG

GAAAGCCCAA

GCTCAGTTTC

AGGATGAATG

GGATGGAGTG

CCAGCCTCTC

GTCTCTCTCT

ACTTTTTAGG

GGCCTTTACC

CAGGATGTTT

TGGGAGTTTT ATGGAGTGGT GGAGGTGGCT

GGAAGATGAT

GACGT-FCAGA

GGAGCCTGGA

TGCAAAAAAC

AGCGAACCTG

CTTTAGACCA

GCAATCATGT

AGAATCTCTA

CACAAGAGTT

TGGGAAAATG

TAITTTCCTGT

TCTGAGGTAT

ATGCAGAGT7

ATITTTAAAA

GCTGTGCCAC

cccT-rTAAAA TACAGAAAYI7

TTTTAGACAC

TATTTATCTC

ACATTGATTT

GCTCTACTGG

ATTACTAGAG

GCTGCTGCAG

CAGCAGCCAT

GCAGTGGTGG

ACCTITGACAG

ATTCTCCTGG

TGCTCCTCTT

ATTTGGGGTT

AGGAATGCCT

TATTTCCCTG

AYTATGGGTA

AAAATATCTA

ATGATTTCAA

TCTGAAGTAT

AAAGCTAGTC

TAAAGAAAAT

TTTTCCTTAG

TAATCTGTGG

CGCAAAGAGG

TGAGCTGACT

AAAATGCCCA

CACTAGAAGT

ACAGAAAGAA

TTTGAATAAA

CTCCTCTGTA

GACCAGTAGT

CTACACAGAT

TGTAGCCAGG

CTGAC17CAG

GAGGCTCACA

AT7CTI17CCT

AGTTTGGCTG

CTCTCC1TCT

TATATGGTAC

CTJ7CTCACTT

TCTCCTGTGC

AAATAATTTA

TACGACAGTA

CTGTAACTAA

TTCAGAAACA

CTCAGTGGGA TGGATGGGGA TCCAGCAGCC GATCTCCTCT CTGCCATGCT GTTCTGCCGT ACAATAAGGG GCATGGCAGG AGGGCTATAG AmTTCAGGC ATATCAATGT AATCAAATAC CATTCAGGT7 TTTATAYI1'G CTTTGTCAT TfCT1TrT-AA ATAGATGATA GCGAACCTAA TTAAAATTAC CAGAAACTTA GGT[ATTTCT CTTTATGTTG AACAATGTTG GGAGATAAGA CAAAGAGGGA GG17ATATAA ATAATATTUT TITTCCTACTT ACAAAGTTAA ACGAGTGGTT ATTTTAATAT TTAAAATACA GGCTTGGATG AAAATGCAGA ATATTCAAAA CGTCTGACCA CCCTrCTAAG AAAATGCATC AAGTTATTGT AAAAATCCTG GAGAAGCT[G AACACAGCAA AGCAAACAGG AAAGCTTfAGG GAAGAAAAGC AAATCATTAA AAATAGGTCT TCCTCTGAAG GTGGAATAGC AATGATAATA AAAAAGCTGG CATAGAGAGT GGCACAATTF GGATGTGTTC TGAA1TCTA GGCAYI7AGTG TACCTTTCCA CACGCATTCT CACACTGAAT ACTT1TTCA TGCAATTTAA AATAAGCGCA CCATCTAG'rr TATTTATCCT AAAATAGCAG AGATCTAGAA GAAFTGAG CTCTAGGACA GAATCTGGAC AAGTCTTGAC CAGACATGAC AGAATAGAAA 17CTTTTCC A1TFTCAGGA TCTTACAGTG GACAAGTTTG TTATCTACAC AT-rGTGAAGC GCCTTAGGAA GATCTGAGAG GTGACTGAGC TGATTGAATG ATCCGTGACC AGAACTTTAC TGGTGGAGAC CTGCTGGAGG 1TTGAGAGCA GACT'rrGAAA ACTGTGTGGC TAACTGGATT ATGTTTAGAG GCTTTCAGAA CTATGCTGCT ACGCACAGAG AACATCTAAG GCTCTTGAAT GGGGCGATAG GGACAGATTT TGCTCATT- GATGCTTTCC CTGCAGGQTG CAGTGTGCAG TGTGCAGTGT CAGGAATACT TGCTTCTGTA GCCCTAA'TrT CCGGTTCAAA CTCTGCATTC TGGCCAAAAT TTAGTTrAGGC TTCTGGGCTT TCTCTTATGC CCACCTGCAG T7AGTAAAG AGCTCTGCTA AGTCAGTTTA GCAAGAATCC CCACCTCAAA GTAGTGTCTG GCTITGTCTrC AGCGAGAAT[ CTATTAGGTT CTGTTAGATT 186 ACTTTTrGGT AAAATCCAGT AGTCACTATC TCCCTCCCTG

AGAATCCTCC

CCTCGGCTAT

CCATTGCCAT

ACATTGAACC

ATGCTGGATG

ACAGCCCCCT

TTTTGCCCAT

CTAAGAAGAG

TCATGGGGCT

CAGCACAGCC

TATACAACTG

CTGCCACCCC

GAAGTCTACT

ATGTTTTCTC

CTATAATACA

GAGTATGCTA

GGGCACCCCT

TCCATCCCAT

CAAATrGGCC

TAATATTTAA

AAATAGCAI17

ATTCCTJTGAA

GCTATATAGA

GGTTGCGCTA

CACAATGCCA

TTCATGGAGT

ACTATGGACG

TGACACTTAT

ATAACTCAGT

T[ACCCTTGA TGCTTCCTCT TAGTATTTTT TCATCCACTG ACTCCY[GAC CCACCTFGCT AAATTCCCAC TTGCCCATAC TCTGCAGTTA AGACTATTTT CTCCCCACTA CTGCAAAATC GGTCCCTATA CTATCTCAAT GGTAATGAAT AAAGTCTGCC TTACCATGCT TTAACAAGTA ATTITTTCT TTAACAATCT GCTGCACAAT GAGATTACTA AAACTTTATT CCATTT-TGCC TCCTCAATGG AATGGCTCT-r GTGAGCACCA AATCATTGTG AGAAGGAAAA CCCATCTCTT GTAACGTGAT GTATGTTACA TGTGATGTAT GTTACATAGT TTTTTCAT GTTGATCACT TT'TGCTATAT CTTATCAGTr GGAAGACTGT GGAAGTTTGT AGTACTAAGC CACAAGATGA TTGAAAGGGC AAGTGGGGCT AAAAACAGAT TTTGTTTGAC TTACCCCACC ATTCCCCCTA GAATCTGCCT GGAGGAAGGA

AAGGCACTTG

ACCCTTGAAC

TGAGACAGTA

TGAAGATGAC

TTCCTCCTAA

TATGACATAC

TTAGTGGTTA

GCCCCCATGT

CAGTAAATGG

ACTCACCTTG

GTTATAAAGT

TTrGTTAGAT

AAGGCAGAAA

AGCTGCATCC

GTTATGATGG

TCATAACCAT

CAGAGTTTCC

GCATTGAAAA

CCACCCCACA

CAGCACAGAG

GGGTTTCATG

AACATGAATT

AGATCAATCA

AAGCACAAAG

TTTTTTAACA

AAAATATGTC

GCATCTTrTAT

AGACTAAGTA

TGAATTGCAT

ATCCTCTTCC

ACATTTATGA

CTTTCTTCTC

TTAGTTGACT

AGTTTTCGAG GAGTCAAAAG

TGTTCAAGGG

AAAAAGATAG

CTCTGTGAGG

TGTTCTTTrGT

AACCTCCCGT

TTGGATAGCT

YJTGGACTGCA

CAAYITTTAAA

GGTATAAAAA

TTrGCTATTCC

TCAACTTTAC

CTACAGTATC

GGTAAAATGC

AATCGTTAAT

ATAGATGATG

AGTAGTCATA

GTAGAGGAGT

TGTGTAC117T

ATTCAAAATG

TCTrTTTCAA GTGAAGATAG GTTTAATCTT GACCCTATAG CAGATGTGTC ACATTTCCAT GAGTTTCTGA CTTrGTACTG TGAACCACAC AGTCTAGCAG CATGCAATTC TAUTGTAAAG GCTTAAAATA GGTCAGTTAT ACGCAGATIT TCTTCCACCT TCCTACTCCT CAGTCTACTC AAAGATACTr TGATCCACTT CCACUTAGTG AATAGTAAAT TCTAGCTTAA TTTATTGTTA AGAATACAAT GTTATGTTA TCTGTAAGGC TTCAGGTCAA GTGTATGTGG ACTTTCAACT GCAGGGGGGT TGCCAAAGGC AAGCCTAC ATCCAC1TTTT CCTGCGTCAA ATCTTTTTTT TTGCAGATCA CCCAC1TICT TTAGTAATAT TTAAGYJTAGA TGTAATTTTF ACATAGTTTC TTTCAAACAG AAACTCCTTT TAAGGGCTAT CTGAA17TTA AATGTACTGT GGCTTCCCCC AACCATCTGG CTTACAAAGC ACAGAGCAAC TTCTCTCCTG TACCCAAAGA AAATCCTTAT TATCAACAAT TCCCAGCTGA AGTGGAGGCA AAGACTCAAG ATGACCAT1T AGTAAGCACC TGAAGAAAAT CTCGAAAATC TAAYUCTCCA GATGAAACGC ACTGGCCATC ACATTTGACA CAGAGAAGTC ACCATGGACA GAACGTCGTC TGTGGGACAT GCAGTTTAAA GGCAGAACAT AGCACATATG T'TCATCCTAA ATAATCTGCA ACCAAAGCTT GAGGGGAATG GGATGAGAGA GAGTGGAGAT TCAGGTTCTG AACTGAAATT TGTATACTGT TCCTATCTGG TTCAGAAAAT AGGTGAATAA TAGGAAACTT GATAGGAACC ATGATAAATG TATTATAAAT CTTGTTTTGC AGATGGAGAA AAATGATACT GTTACATGAG AAAGCTGCGT TCCC=FTGC TGCCAGCTAT CTTGGGTAGG TTTTTTTTTC TCTTTTTT"TG TI7GAGAGAGT CGGCTCACTG CAACCTCCGC CTCCTGGGTT AGCTCGGATT ACTGGCATGC ACCACCACGC ATGTTGGTCA GGGTGGTCTC AAACTCCTGA GATTACAGGT GTGAGCCACC ATGCCTGGCC GACTGGGCTT CTGCMTGAT CCTrTCTGCA AGCCCCTAGT TAGAGGCTAT GTCTCTGCTG GAAAACTGGA ACTTAGAGGA CAGGCACATC TGAGAAATGG

TGACTGGGTT

CCAAAAAAGA

TAATGGTGGG

AAAGGCACAA

ATAGTACGAA

CTTAACTCT-r

ATTGAATFUTT

ATCTGfTCC

TGTGTTCCCT

cTfrTCCCTGT

CAAGTGCTTC

CCACCTAAT[

CCTCAGGTGA

CCAAATTTAT

CTTGCTGGAC

TITCCTGAATG

1TGTCTCAA

CCAATCCAGC

TrTTCAGTAA

CAATTITJTCC

CATTAGATTC

CCATGAGAAT

CGCTCACCTC

11TAGAAGCAA A'TTTACAAGA CGCACTCTTC CAATTTAGGA ATGCAGAGGT GAGGAGTAGG CAGAGCGAGG MrAGAACT'I ACACCATTTT TAACAAAAGT 117ATTAAAAA TAATAATTTC AATCTTCAAG GAACTCTGCT AACCCAAGTT ATCATAACCC TGGATTTGTA GCCATAATT[ TTGGGCTGTT TGATACCCCC TGCCTAGGCT GGAGGGCAAT TCACGATfCT CTTGTCCCAG TTGTATT-MI AGTAGACAAG

AGTGGTTTCT

GAGCAGGACT

CACTTATACA

AGGGATATAA

TTAAATGATT

GTGTCTCAAG

ACATTTATCT

GGCGCGATCT

CCTCTCTAAT

GGGTTTCTCC

AAAGTGCTGG

TAGTTCCCAT

TTGTGTCCTG

ATTAAAAGTC

GTATTATGAG

ACCTTACCTA

CCCCAACCYI7

GTGGTT-FCAG

AGATCCCTCA

TCTGCCTGCC

C1TTAATGCC

CCTCTCCCTG

GGCCTCCTGG

AATCATTGAA

TGTCAAGGCC

TGGTACTCTA

ATGAAGGGCT

TCACAAGGAG

CTAACACCGC

CTGCCGTGCA

TTGGCCTCCC

CCAAATrATC

GGAAATGAGA

ATGAGACCTC

ACCAATTAAT

AATTTGTTCT

GGTTAGCAGT

GGGCAGGGGA

TGCGCAAGCT

TGCTGATCTG

GCTCAGTTCC

TATAAGCATC

ATGATTAT

GGAATATGCT

GGGTGCTAAG

TAATTCTCTT GGAGAATTGA CCTCTATCCA GTGATTTGTA GTAGGTAAGT CTGGAATTrGT TrTGGCACCA GGGACCAGTT GATGAAACTG TTCCACCTCA CACATGCAGT TCACAATAGG

GAGATACCTA

CCTCAATTCC

AGCTGTGGCA

TTGTGGAAGA

GATCATCAGG

GTGTGCACTC

CAGGGACCCC TGTTGCTAGG TATCTGATGA GATATAAATT ATATAA117AT ACATAAACTA TTCATCTTAG CGTAGTAAGA CACTGGGTGA TGAAAGAGTG GGAGCAAATC AATTAACTTC CTCTTCTGCC CTGTATACAG CCTCATAAGG TTAAGTAT ATGATGTCCG ATTA1TTTAG AGCAAGGCAG ATCCCAAITrC TCCTCTTT CCTACTATTT TCTITTTCCT CCTACCAAGA T-FCTCTGTAT TACTTTTATA ACAGGAGACA GAGCTCAGGC AGTAATACTC ATYI7GCCTAC TAACAGGCCA CGGACCAGTA CTGGTCCACG GCGCAGGCAT TGGCTGCTGC ATGTCTrCTG TGTAGCTACA TCTGTATGTG AAATTACTTI' CTTCATATTA GAGTTGTGAA TGAGTATCAC TTFAATAAT GTATATAAGT AAGT1TCCTr AACTATGACT AAATAT[-GT GATGAAAATA GGCATTGGTA GAGTTGAGAC TAAAGATT AAAGCCTfCA 'I17GAAGTCTT

TAAATGCTAG

TATGCAAGAT

CTACT7CCAA

CCAATGTGGT

AACAACTGGT

CCGCAGGATC

CTCTGTCACA

ATAGGGCAGT

TTAGCTAT[A

ACTATACAAA

GAGAGAAAAA

AACGTGAAAA

AAGTCTATAC

GATGCTGGTTF CAAGGTGAGA TATGAATACT TAATGTTAAC TGATCACTAC TAAAATGGGG GTCCAGTAAA TATCACATTC AATGCTGTCA GTrTTACTGT TITrGCATT TGAATCAACA TCCCCCAAAT CTGGAATTCT

AATGTGATTG

ATATGTAAAG

ATGACATAAA

AATTrGAATCC

TCTTATAGAG

AAACACT17rC CCT-rTCTTAT TTrACFrGG CTATAAGGGG TAAACCTCAA GTAGTACAAG GATTCCC1TT GTTTCCTCAT CTCCATGTGA ATTTAGTrAA ATTCTCAGCA UTCTGATCCT TACTATACAA GGTAAATGAA TATAAAAACA AAACGAAACA AAAACCTC'rr 187 CCTATFTACA TAAGGCCCCA ACCTAATATT TAGTGATATA TATTAATGTG AACAAGGAAC TAACGAAGAC TGGGAAGAAA TTCACAGACT TGAGAGAAGA AATGGCAGGA T11TCCTGGGA ACAATTTCAT GTAACGTCAA AGGTGGTAAA AGGTCAAATA GAATGAAGAT GGAGAATACC GGATTTTCTT

ATCTCATCAA

TTACAATTTG

TCAAACACTC

AAACTTAAAA

AAAACATCTC

TGCTGGCCAA

ATCTGGGTTG

ACAAGCTTAC

TCCTGCATCT

ATTAGGTAAG

TYrGAATGCAG cTTTcGGccT-

ACCTGTAATC

ATGCACGAGG ATACCTTCTC GATAAACAAA ACTAAACAAA AAATFTTTGG TCCYFCTGTT GTTATTTCAA TTATGAACCT T11TCTfCTAC AAACTTCTGA AAGTACACGT CCATTTTTAC TAAATGGTTT CTGAGGTGAG AAAACTCAGA CCACTCACCA AGTT-rCACCT AGTGAGTAAA CAACATCAAA ATT[FCAGAAA TATTITCATTrT TGGATACTCA

ACAAAATGAT

AGACTGGTAA

AAATAATAGC

GTGAATGTTA

TTTCACATCT

GTTACTTCAT

TTATACCTAG

TGTGAAATAA

AGATCAGAGT

AACAAGATGG TTTTCACTAC

CTAACATCTT

TGGCTCCAAG

TCCATTGACT

TCTCTTCTCC

AATGGGTGTT

AATGCACACA

TCAATTATTC

AGATATTTCC

AAAAAAGAAA

CCCACCCCTC

GAT17GGACA

AAGAACAACA

CTAGCTACTT

AACTTCACTT

ATGCATAGGT

AGCCCTAAGT

CGCAAACTAG

TATCTACTGC

CTTTATACAA

CCTCTCCCAT

AGTGGGGACT

TGCTTCCCGA

TCGCGCACCA

GGGCTCACCA

CGGGACTGCG

TCTCAGGAAG

GCCGCCGGGA

GAAGGGTGTG

ACCGCGGCCT

ACAACCGTGG

TAGCAGTGGA

GTAAATACTT

TCTTAATAGT

TAAGGGCTT

AGTAAATAAA

AAGTTCTCAC

CTGTTGGATT

TGTGGTrGTA

CATTTGAGCC

ACTGCACAAA

ATCTCAGAAG

TCAACYITGAA

GACATGGTGT

AGAGACTTCA

CCCAAACTTC

CTCACACACC

CCATCCTCAT

G1TTcTAcTc W1AAACCACT

TACACTCTGT

CT-rTAAATCT T-rCCT-rGAAC

TATGTTCCCA

TTGACTT

AATTCAU-TT

ATCTITTAAAT

AATTAGTTTT

GGCTCA17TA

CAATCACCAT

TAAACCTGAT

GCCAGGAGGT

GAGAAGAAAA

TGATAACTTA

TTAGGCATAG

TGCTGGCTGC

CAAGTGATCC

TCTGAGACTG

CCAGATGGTC

TCAGATTCTT

GTTGGGCCCA

CTTCAATCCT TCATCAATTA TTTTGAGTAT AAGAGATGAA CACCTCCACC TACACCAAAA TTAACAGTCT AAGGAAAGTC TGGTGCAAAT AATGAGATCA TAUTTTACAA AAAGTTTTTC GAAAAAAATC GGCAT=ATA TAGTTGTGTT CATCATTTTC YITCATCTTCC AAAGTGGAGT ACTGTFTATAA TCTJTGAAAGT GAATTTCYT CCACAACCAA GATCCAAGAC T'TTTTTCCCA CAAAGGTACA TTCCCAGATT TTTAAGCCTC GCTMTTGAA ACTATGTT CTCCAGGGAA ACATGCTGGA AACCTGGTAA TGTTTCTATG CATGCTCTTr

ACTGAGTGGA

TGAGGCAAGT

ACAGCTCTTT T

TTCTATAGTG

CAACTTCTGG

ATTTCTCTTT A K3CAGCTCTC AAGGAGGGCT CTGTCTGTGT CTTGAGAGGG CAAATTGTTC TGCAGAACAT GAGGAATCC AGGGTCAAAG kAA~rAAACT GAAAGGTCAT kTAGAAT[TG ATGATACACA ~GCAGCTTAT ACATGGTAAC TfCCCAGGAG

CATAGCTCAC

AAAACAGAAA

ATTAACCAGG

TCTGGTC'rrA

TAATGTGCTT

TACTATAATA

ACTACTfAGT

ACTTT'TGGTT

TAGCTACTAC

GGACCCTCCC

GCAAATTTCA

CCTCATAAAC

GTTCTCTTTC

ACTTrATTTT

GTTTTCCATG

AGCTGCATTT

TTTCTGTCCC

CTCCATCTCT

CCTCYJTATTA

CAAATCTGCC

AAATATTTAG

AAATGACT-rT TTAGACGTCT Y-FGGTCCTCT TTCCAAGCAG CTCTGGAAAG AAAAAAAAAA GAAAATGATG ATITAAAGCAA AATGGCACAT TTCACTAAAG TGTAATATTA AACAGCCACC CCTGTCCCAC CATACAGCTG CTTTTTCTTA AAAAGTTGTG GGGAAGAGAG AGAGATAAGA CTCATACACA CCTTAAGGGT TCCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG

GCAACCACCA

GCTGTCTTTC

CTGTCTfTITA

ATGGCCTGGT

GTATAGAAGT

CCACTACCAC

AGCTGTCTTG

CAGAAGAGGT

GTGTGTAAAT

GGGGGTAATT

GGCACTGCAG TAGTTTGGAG GCTAGACACT ATACCATCTG GATTTACAAT TTGGGGGAGA CACGCTGCAA GGCTTGGAGT TCTGGCCCTC ACCTCCCCAT CGTGTCCTGG GATCGCGCTT

CTGGACAAAC

ATTTGTGTCC

GCAGTATMT

TCATCCAAGA

TGGCAATAAT

AGACCTGTAG

CCTCAAT

GGCGGGTCAC

CACTTCCGGC

TTGAATGTAA

CTGAAAAAGC

ATAAAGTCCA AGATATTCAG AACCATATTC ACCCCCTAAG AT1TrIGGTAA GTCAGCGTCC CTTCACTCCA AACATTTAGT TAGTAAAGAC TAATTCGGTG AAATAAGAAG CAACTTTATr CACAGTTCTG GCAAGTGGGA CCAGTCCCGC GGCTAGGAAC TGCAGGTCCC GGAACAAATC TGTTrACAGT GATCCAGACC TCACCTCACA ACGCCTCCTC

ACAGGACAGC

C'rrCCAGAAT CnFrAAAAAC

CGAGAACAGC

GCAGAGCAAA

GAGAATCTTC

TCTTTGTTCC

GCGCCTCTTT

CGACCCCAGA

TGGGGATGCT

CGGACCTAAA

GTGAGTCGAG

AGAAACCAGC

AG'TrTCCGGT

GTGCGGTCCC

ACTGCCGTCC

GGCGGGTCGC

GAACCCCCTC

TAGATTTAAG

TGTGGCGTTr TCCTCCAGGG GCTAGAGAAG CCCGACTTTC TTTCCGGCCT TGAGGGACCC CGCCCTCCTC TCTATGGTTT TGGAGCCGGC GGAGAGCGCG CAAGGGTTGG CTGGGCT-FTG GCGGGTCTGG TTTGAAGCTC TCCTGTTTGA CGAAAGTATG AGCTAGCGCG GTTCCCCTGG AAGAAUTAAG TAGCTGGCCA GAGGAGCTAT GTCCTGCCCC GACTCCTCAT ATCCTTCCT[ GGTTGTCACT TCTACCTAGA GAACCTTTCT CTITCTGTCCC YI7CAGACCCA CCGCCAGGCT GGGTTATArTT TITICTTTGT CAGTGAGTGG GATGAAAAGT GAGGGACTGG AGGGGAAGCG TAAGGCUTTG GCCCTGGAAA GCCTCGCGGA TCTTCCATTC CTITCTTTCAG T1TTCTGTA TTGCTAGTGG ATAATGGGGG TTGAGGTAAA GCGAGATACT CTTAGCGTTA TAAGAATTAA AATGATTTTFC CTCCTTCCCC AGGCAAGGAC TGAGACCTGC CTGAGCTI GTCTCCCGTA AGGGCATAGT TCTGTGGTGT TCTCAGACCT CTTTrTCTTC

TCCTCTCACC

TGAGGCGCTT

AATGTGCCTG

CAGCTTTATA

CAGOCTOGAG TCTrrCTGAA AGCGCCTJTCT TCGTCCGGGT GAATCCTAGC C1TTCATGGT CAATTACACT CAAAAGAAAA TATTGTGCAG CTAAAGCCCT ATGTAATCAC GTGCCAAAGC CCCCTT= AGTTTTTGTG AACAAATAGC CACCCTCAAA ACATTCAAAA TAGGCTTTGG GAGAACAGAG ACACGGAACG TrTAAGTrGAA AGTCAACATT CCCACCTAGC CTCTAGTTTT CT-rCATCTGA GTAAATGGTT CGATCAGTAA GYI7CTATTGT TTCTGA'rrCC TOCTACCACT CTGATTCCAA ACCCTTATCA ATAATTCATT ATTCCAAAAA AGTTAAGAGG rITACCTTCAA GGTJTCCAGGT GATCTAAGCC TCATGAATAC AT7AGGCTCA CCTACCTCAA 188

AGAGTTCTTC

GCAGCACA~r

AAACCATATG

AAAGTAACCT

ATAGAAGTCA

TAGGTACAGA

ACACTTAAAC

TGATTCCTCT

TTTGCACT-rC

TCACAAACTG

AAACTATGTC

CCTCTCAC'r

CGTGT-FCTGA

CTCGTTGCTT

GGTATGACGA

AAAAGGGTGG

GAAATCTTTA

TTFCTrTCTT CGC11TGTTGT

CTTGATTGGT

TATATGTATC

TCACUrGAGA 17CACCTAGG

ACTGCCGTCT

TGCGTGCATA

TCTTCCCCAC

AAACGACATA

AAACCTTGAA

TTGAATCAAT

GGAGTATTAA

CCCAAGGTTT

GCAATTAAGT

TAGCTCTGGC

TGAATATGAA

AAAGATGTTC

TTTTMGAC

TGGCMTCAA

CTCATGCCTT

TITF=CACAA

GAATCTCAAT

CATTAGCAAA

TCAAGGAGTT

ATGTGTGTGA

AAGCTUATAG

TTCAAAAAAG

TCCTCTCTGT

CCGTrTATCT

TAGTTTCCTT

ATTTCCCMII

GTTAATTAAC

TITGTTCTCT

GGAAAAACAT AGATCTCGTC T[GCCCT[CT CTCATACCTA GATCTI1TG CTCAGCCTGA CAGCCTrTTG CTTrCAATCTf7

AAAGCACATT

CAAAG'f7CAT

ACATAGTAAG

AATACTT

TCTACAATGC

CTGCATGTCT

TTTTCATGAG

TGTAAAAAAT

GTYI7GTTTGT

CTCACAGCAG

CACCATGCCC

ACTCCTGACC

CCGGCCGGGT

11TCTAACAAT

TGCTATGTGC

AGAAGGTGAT

ATAGAAATCG

TGGGAGGATC

GGGTGACAGC

GGCGCGATCT

CAGCTGGGAT

CACCATACTG

GGATTACAGG

AATCATAAAC

TrGAAAAGGC

CCTAATAAAT

GTCATTGCTT

CTATGATACT

'I17CGTAAGTA

TAGATGTGTI'

TCAGTTACTT

ATACCAAAGT

AGACCTATAT

GAAAATGCTT

ACTTTCTCAT

GACTGCTCAG

TYfATAATTTG 1TGTCACCCA

ATTCTCCTGC

ATTTTAGTA

TCCTGCCTfG

TGM~TGYITT

TGCAGCCTGA

GAGCCATGAT

CTGGAGTGTA

ACCTCAGCCT

'TTATTTT

CCTCCCGCCT

AAGTAAATTA

AAAAACAGAA

TITCCGTATA

A'ITTTGGAAA

CAGATCCTAT

CCITI7CTCTC

AGTGTATCAA

GACAATAT-rT

CTCATATGAA

CCTGAAAATA

'I17CTAATATA 1TAGTGTGAT

TCTCTGAGAG

AAACCTCGTC

TTrGGGAGACT

TITGCACTCCA

ATT1TTCAGAT CATATTCAT GTTTATGTCT TGGCCCAAAT AGGCAGTITCC CCCAAACGCA GTCTTACACT ACCATI7AAAA GAAATGCTCT TGTT"TGC1TT AAAGGCAGGA TG'FfGATT CTTCACAGCG CATTCATTAA AGGGCTAAAA ATATTTCATG TI7CAGCTTAA TGGTAGTATT TTrAGCTTCAC CATTACCCCC CAAAATCTTT TTCATGTTTT GCATAATCAT AACTGACTAA 'TMGGAACA GCCAA'FrCTA CCCTACTGAA CTCAAA'I1TTG AAGATTTCGG AAGAGGAATG AAT7rCTrGTA TTGTTTTGAG ACGGAGTCTC ACCCTGTCAC CCAGGTTCAA GTGATTCTCC TTCCTCAGCC GGCTAA'TTTT TrGTATCTTT AGTAGAGATG TCGTGATCCG CCTGCCTCAG CCTCCCAAAG TATTCAT-rTT TCTTATTAAC ATTCTTTGAT TATTCTAACA AT"TATTCT-FG ATGGTGTATA AGAAGAATTT CAGTCAAATA AAGUTGGTAA GAGTGACTTA GGTATAAATFT AAGTACAATA GAAGTACAAA CTGGGCATGG ACTTfTAGCCC AGGAGCTTGA AAGACCGTCT CTCTT1TT-r

TGGCTCACTG

TACAGGTGTG

GCCAGGCTGG

TGTGAGCCAC

CTGTGGATTA

AAGFTGTCC

CTTAAGTTTT

AAATTI7CAAA

AGTATCTTCC

AAATTG'Ir

CTTACAGT

GAAATGAACA

GTT-rTGTTGA

AAAACATGAT

TCTAAATTGC

T'FrCATGTCT

T'FJACTCATA

AATCTACGTT

GGTTGGAGTG

CTCAGTCTCC

GAGATGGGGT

GCCTCCATAA

rCAAGACAAG

ACTCCTGGGT

GCTTIGGCCTG

GTGGTGCGAA

TCCAAGTAGC

3GTAGACATG

CAGCCACCCA

CAACCTCTGC

CGCCACCATG

TCTTCAACTC

CCCACTTGGC

TTGTAGCATU

CTGGGCAA'

TAAAAGCAAA

AGGGTFAT

TFTAATTATCC

AACTGTATGA

TGTATTCCCT

AATTCAT7CA

TGATGTATGT

ATGCAGTCTA

CAAAAGCTGA

TCATCAGTCT

TIIGAGTTA

GTGTAATGGG

CAGTGGCGTG

CAAGTAGCTG

YTCACCATGT

GTGCTGGGAT

ATCTCACTCT

TCAAGCTATT

TGTITTGTT

CATAGCTAGC

TGAGACCGCA

AGGTCTTGTC

AAGTGTTGGG

TGGTGTGCAT

GGCTGCAGTG

TFTTUGA

CTCCCAGTTT'

CCCAGCTAAT

CTGACCTCTT

CCCGAGCGAG

GTFTCTCATC

TTCAAAATAT

ATTAAGCCAG

TT]TTTA

TACTCATTGT

TGTACTTTGA

TGAAATGTAA

AA~rCCAGCA

ATAAACAAAT

CTGAATAGCT

Tf7GTCTAGGT

TACTTGATGA

GCTTTTCTAT

ACCTAATTTT

ATCTTTGCTC

GGATTACAGG

TGGCCAGGCT

TACAGGCGTG

ATTFGCCCAGG

CTCCTGCCTC

TGTTTGTTT

TCACTGCAGC

GTCACTTCCT TAGAGGGGCT TTTTCAGAGC TGTATCACAT TGGCCTGTTC AGTTTTrCTAA GTATATTTTC CACTTCTACA CATTATG'FFG TTACCCTCAG CACCTAGAAC AGTGCCTGAC TTTTAAAAAT ACTTGGGAGT CTAAUTAGAC TATITrAACA AATGAAAAAT TTGCAATAAA GCATTTTACG TATTATTTFTC CAGGCCTTAC GCTGGTAATT ATTTGAGCTT TACTGAAATT AGTTAATGAT GACCTCA'FFT TGATTGCTGC TTACTGTGGT AGGACTATGG GTrTF!T CCAGGCTGGA GTGCAGTGGT GCGATCTCAG TCCCGAGTAG CTGAGATTAC AGGCACGTGC GMTCACCAT GTTGGCCAGG CTGGTCTCGA TGCTGGGACT ACAGGCGTGA GCCACCGTGC GATTCTTATG GTGTTGTTAC AGTAAAACAT TGAAGAATTT ATTGTCGTGT A'FrTGTAAGC GATAGGTATG TAAGTAATAT GAAAAAAGAT GAAATGTTGA GGAAAGAAAA ATTTCTTGTA CTCTAATCCC AGCTCCTTGA GAGGCTGGTA AGGTGTGATC ATGTCACCGC ACTCCATCCT GACGGAGTCT CGCCTATGCT GGAGTGCAAT CAAGTGATTC TCCTGCCTCA GCCTCCTGAG TA1T=GTAT TTTAAGTAGA GACGGGTTCT G'FICGCCCAT CTAGGTCTCC CAAAGTGCTG ACCCTCTCTC TAAAAAAAAA TAAATAAATA TGTCAAAAAT ATTTCATGAC TATGCATAGT T-rCTrTAATG TGTTTCACA ATACTG'FITA TAATTTGAGT CCAATTCCAA TCTCTTATGA GG1TGTTCT GAGTAATGAA TACCCTATTA CTCAACATTC TGACAGT[GG ATTGAGCATA TG17AAGGTC CGAGTCCCCA CATACCTCGG CTG'TFCTCTA TGTTACAGCC 'FrTATAACCT CTTAAAAGTT TTAAATI7ACA 1TTTGGATAA TGTAAATATT AAACGTTAGT TGTTACGATT ATCAGCCTCT AACATGTTTA GTGTCATTTA GATAACAAAT TTACCATFITG GAGGAAG117G GATTCATTCT TCTAGTCAGA AGAGAG'rrTA TTAGAGTTCA C'FrGG'FrGTG GAATATTCAT T'ITTTCCTTT G1TTTTTGTTG GAGTCTCGTr ACTGCAACCT CCACC'FrCCA GGITCAGGTG CATGCTTCAC CACGCCTGGC TAATTTTITGT GGTCTCAAAA CTCCTGAGCT CAAGTGATCC AGCCGCTGAG CCTGGCCCCA GAGTITGTTT CTGGAGAGCA GTAGTGCGAT CATAGCTCAC CATCTTCTAA AGTGCTGTGA TTACAGGTCT GGGGGACAGG GTCTTGCTTYr GTCACCAAAA GTCCATCTCC CACGCTCAAG CAATCCTCTC GGTGCGTGCT ACCATGCGTG GCTAAT'TrTC TA'TrATATA ATGTITCCCA GGTGGTC'FFT AACTCCTGGG CTCAGACAGT A117ACAGGCG TGAGCCACCA TGCGTGGCAT AATTTTT TrTrT7TATC YI'GAGTATAG AAGTGATTCA TGTTCATTGT GGAAAATATG AAACATATAG AAGATTACAA AACATCTAAT CTGAAATGGT

TTCCTGCCAG

CTI1'TGTTT

TCAATAGATG

'TFI17TTTT[ GC'TrTAGATT

TTATAAAATT

CCACCTGACA

CATGTrATAA

TCAAATATAT

CATTAGGCAG

GCTGAGGTGG

TCTACTAAAA

CCTATCCATC A'FrGTTCGTA AACTACATTG TGAACATT TACACACACC TA1T~AACTG ITI17GGCTA CTACTTAATA GGTAGTA'FrC TGTTA1T[GC TTrGGAACAGA

GGAATCTAGC

TCAAAATAAA

TTAAAAACTG

GCAGATCATC

GTACAAAAAA

TTGCA1TrAA

TTTACAGAAA

CMT'rrC

CTCAGTCTTA

AATAAGGAGT

TTACAGGCTG

TGAGGTCAGG

TTAGCTGGAC

GCCTGGGAGG

TAAGATTTG

CATGTTTATC

TCATGTTTTA

GTCCACAAT'T

GITTrCTCTGT

TAAAGGGCAG

'I=GAAAAT

ACAAGTGTTA

GATGA'TrAT

AAGTAGATCT

GGCACGGTGG

AGT7CGAGAC

ATGGTGGCAG

CGGAGGTTGC

ATGAGAACAG

TACATTAAAA

AAATGTCATT1

GTTGGATATG

ATAGAATGTG

TGGCCTTTGT

TATTGTAGAA

CCAAAGGTAT

TATTAATTAT

CATGTGAGAC

CTCATGCCTG

CACCCATGGT

GTGCCTGTAA

ATITGAGTCAA

TCTCATCTCA

'TrGGTGTTrAT

TTAATGATGG

TAGGTCGT'rr GTA1TFGAA

TGACTGACAT

ATGTT'FITAC

AATACTATTA

GGCTCTC1TJ

TATAATGGTG

TAATCCCAGC

CAACATGATG

TCCCAGCTAC

GATCGTGCCA GAGACAGGAG AATTGCTTGA G3CCTGGGCAA TAAGAGCGAT GCTCCGTCTC AAAAAAAAAA AAAAAAAAAA AAGAACTTAT TGTGTGGTTC CTrACTAAC TGAATTTAAA FJ7ATTrTGTAG TCAATTrAA ATGCTCTTGT 189 ATTITAAAGC CACTGTACTC CAGCCTGGGT GACAGAGTGA AACCCTTAAT TCAAAAAAAA AAAAAAAAAA AAGAAAAGCT GGAATATTGG CAAAATGAAG TAACTAAGAG CATTT-fAGAT ATATATGGTA TATGTTTTCT CTGAAAAGCA GAACTAAAGA TACTTTGGTG CCAAAATGAA ACATTATTTG AC11TTAGCTT TGAATCGTAA TC1TUCAAAT TTCTTGTACT TAT-rTCTTAG AATTTrGTTCT TGACCACCAG AAAAAGATTC GTGTTAACAG GCCTATGGGA AACAGTATTT TCT-rTAGCTA ATAATG1TTA GGTCATI7TAA ATTGTTAGAA AGATCCAAGT GACAAAAAGC TTGTTTGTAA GGTCATTTAC TATACCCTTA AAGGAAACTG GTTAGAAAAT AAGTGAGTAG TGAATAGGCG CTTGTAAATG ACTGTATGAA TGTGGATTCT TCAAGACAGT AAAACATTAA ATTCACAGAA TACATTATTA CAAGCATACC TT1T[G1TF TAAATGGAGG TAATTAATCT C17ATTGAAA TGGGTTTCTA CATAGTCACT TGATGATTCT CTATCTGAAA AACTGTTACA TAGATGAAAA TGGATGT[GA CATTGTATTG TTGACTGTGT TGCTATJTCTT

ATTAAGATCT

ATTCAGGAAG

AT-rCAGTGCA

CAAATTTATT

1TFFTTGCAT CTCTAAAACA TGAACTTTGA ACCATAGAAA TGGAAAATAA ATTTCTGTTf CTGTATTITG TGCTTAATTA GGTACAATTG TCAAATrATC GTATTGTGTT TTCTCTGTAA GTGATTTTTT AAAAAAATTG GGGGCTY[FTG GGGGGATTAT TTIAAGCTAGA TGATAGCCTG AGTTTTGTCT TGTCTTrTTCT AGGGTGGCTA ACTTTTCACA GTTAGCTTGA ATTGGGTCAA AA'FrCCTJTCC AGAAAATACC GTGCGAAAGT AATACTTTTA ATGCTATTAA ATAGATTCAA GUTGTAAAAA TACCTTTTCT TGGATGTTAC TAGTGCAAAA AGTGATTTCT CTTATTCCTG TGTATGAATT AACCAGTCAA TATfTTACAA GTAAGTCAAA ATACTGATAC TGATTAGCTA TTTATTACTT GA1TTGTTTT T GCCAGAGGAC TGTCAAGCCA 'ACAGACTGT GAAATTATTC GATGACATGA AAATTTGGAA ATCCAGACCA CTCTAAGGAA AGAGGGAGCT TAAAGAATGT CAAAATTTTTr TGTATTAGAA

TGTATTCTTA

AATTCTGAAT

ATATGTGTGG

AGTATTUGTA

TTTGTAGCAC

TCCTTrATTCA

AGCAGGAGAG

TGTAATGGCC

AATAAACTCT

AACACCTGCC

GTI'CTGATAG

CCAGCATGCT

CAGACAATGG

TAATGTTGGA

TATAAGAAGA

ATGTGTTTTG

ACTAAAGTTC

GACTAATACC

TGCAGCTCTT

AAATATTCAG

AAAGGTCTAA

AAGATTTTAC

ATTGTTGCAA

AYTAAATTTA TAGAATTAAA GACGTGAATA TAGAAACATG GAAGTCATCA AGCTAGCTGA CCCTACCTGT ATIrTTCAAGG AAGTTTGTGT TAGTATTCTA AATGGCTAGA CAGTTGTTCC TGTGAAAAGA GGAAGAGACT GTGTTTTrGTT CATTGCTGTA rTTCAGTGC ACAAAAAATA TATJTCTAAGT GAAATTCCT AGGAGCTCTC ACAGGATGTG TTCAGCATAT CTGTGCCACA AGTCTCCCCT CCTCAGTCCT TCATATAATT AAAAGCACAT TTATACTTTrG AATGGTATAT AATCAATGTG CATAGGOCT ATTTTAGTCT ATATrATTGA AATAAACTTT TCCATAGAAT AAAAAGTGGT TTTAAGGAAG TCATTAAAAG TGGCTTTTTG CAGGAATCCA TCATTTTrGGA TrGTGCAT-rG TAAGGTGAGT GAGTAAAATA ATGTTrGTAT AAAGAACATG TAAGTAAATA GGGTTTTTA GTTTTATCTT ATrCCCCTC TATAAAGAAA GAAGTTTTAA GAATTTGTGT TGAGACAGAC ACAGGGATCC TGAAATAGY[ ATGTCATGTT

GAACTCCTT

CACAAAAGCT

TCACTAGT7A CCT1T[TTAG

GAAGCACACT

CTAATAGTAT

CGTAATCAGA

TCAAGGAGGC

AGATGACAAT

ACTATAAATC

AATTGATTTA

CCTTAACCTA

CTCTGAGGTT

GTTITATATTT

CATATTATAA

UTTTTAGA

CTCGCCTCCC

CCACACCTGG

CTCCTGACCT

CCCAGCCAAT

AATGGATTAT

AGAGTAAGTT

ATTCACTATT

CTGATCCACC

GGCAGAAGTA

TGGUTCAGG

GCTTGCCTTA

AAAAGTGTGG

AGCCTTGCAT

TrTGTCATT

CTGAACATCT

AAAAACCATT

GTTACGTATT

CCCCATGACA

CTGCTCTGTIT

TGTTrTGTTAT

GATTGCATTT

TTATAAAGGA AAGTTAATCC TGCCTAGAAT TrFATGGGTCA ATTAATACCT CTCTTTGCTG GCATTGACCA ATATTCAA1T TTATTTAGTC CATCTCTACA CAGACAGTTT TAATATTGCT ATAGGATGCT AAAAATGTCA TTCTGTA11TT GCAAGATCAT GGAAGTCAGA AATAATATTT *ATATTTAATG GATGTTCACT AAACAATGAA TGAATATGTG GAATTAAAGT AAATTTGGCT C117GAGCTI1 GATTTGTTTT ATAGTGAATC TGTGTATTCT GGGTGTTTAC ACCTAGTTTC CTATTCTCTTF CAAAAGCAGT TAATGGAACT GCTGGACATG *GATGATATTT TGAATATGGT AATAGGTGAG TGAAGAAAAC ATGTATCAAT TAAAATTGTC TCTAATGATT CATGTTATTT AATCTTACCA AATAAATTTT TAATCTTGAA ATrTGGAATT GAI17TGCGTA TTAGTTACT GTAATTTCTC CACAATGATT GTCCATATTC AGAGACAATA ACTYFCACAT TTTTTTAACC CCTTCCAGAA TACATATAAA TACGTGCATA TGTGTATGTA TGAAATAACT CATTTTACAT GTGATGCACT TTATACTAGT CAGAGTCTCA CTGTGTAGCC CAGGCTGGAG TGCAGTGGCA GGACTCAAGC GATTCTCCTG CCTCAGCCTC ATGAGTAGCT CTAATTT-G TATTTTTAGT AGAGACAGGG TTTCACCGTG CAGGTAATCC ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT ACTAGTFTAT TT-rTAAAGAA TTGCTGGTCG TAACACACT'T GAACAAGAGT UTGAAAAACA ATATAAAGGC AAAGTTrGCA GG7TTTGTGC AGTGTATCAG GCACCTGTTG CTCTGCAACA TA'FTrATTCA TGATTCTGTG AGTCTGCAGT TTFAGGGTGGG TGGGGCACTA GCTCACCCAT GTGACTTCAG TGACTTCATT CTTGAGAAAG CCATGTGCAT CATCCAGCAG GTJ7CACCCTA GYITCTAAGA GTAGCAAAAG TGTGAGCAGG TCGCTGTGTG ATTTTATTAT TGTCCCCCGG GCCACAGCAG GTCATAGCGT ATTCACAAAG GGCAGTCATTr GTGGCCAT TTATAAATAA GAATACCATG GATATTAATT TGAATTC'rrC CYITITTAGAT TTGGATTAGA ATTATATCTG TAGAATATTT CAG'rrATAAT YTAGTTTAT TTAGGTCATC TGGTAGGTAT AAACTTCAGA AACAAGTGTG ACACTTAAAT AGTT-rAAATA ATFCTITTGA TTAATTCAAT CAAATGTTGA AATTGTFCAG TAGATAGTT TTTGGATGTC TTAAAAGTTC TGTTATCTTTr C1TTGCAGTT A1TI'CCAGTA TGGACCATGC ATICATGCC AATACTTGGA TTrTTACT'TT TTAGAAAATG TITrCCATAT TCCCCAATCT AAAACATT- GTGTGAATFT AATGTTCACT GACACTGCTG 190

ACCATTATGA

I7GCCAGAGGT A1Tr-GTTGGG

CGCACCTGGC

TATACATGCT

ATTCAGTAAA

TTCTCTCATTF

AGACCTTCTC

GTT[GCATGG

TITCTGCTTA

TCTTACTAAT

TGTAAAATTT

AACT]7ATATA

ATAACTGATA

AATATGTCTA

TTATITTTTAT

CAATCTCGGC

GGGATTATAG

flTGGCCAGGC rACAGGCATG

CATTGATTTT

TTCAAAACTT

CACCACCTCA

ATGTCCTGAG

CACATCTGGC

TCTCAGATAC

CTAGCACT-T

TTAGCCCAGA

rCTACCACAG TTTCTTI7CCT

AGGGTACAAC

AGTTAATATT

CACAACTGTT

['ATTATAGG

ATrCAFCT- AGT1ATAAT

TAATTATTCA

TCTGATAATC

TTAGATGTCA

AGCCTTGAGG

CGAATGAAAA

CTAATGTTAC

TGCATCTCTT

TTTATGATCT

TTTAT11TATC

CAGGCTCM[

ACCCFI'TAGT

GTATATGGTG

TATGCATTAA

ATITTTGGGTA

ACTTTATAAT

TTGAGATGCA

TTCTCATATA

TTTATTTTFAT

TCACTGCAAC

GCGTCCGCCA

TGGTCTTGAA

AGCCACCGTG

ATCACTCATT

TGGTATAAAG

AAATCTATT

ACAACTTCT

TGTTGGCAGA

CTGATGCCAG

TCAAGTTTCT

GTCATTGTAG

ACTGAGTAAA

TAGCAATG

1TTrATTrCCA

CAATATTTAT

TCCAAG11TGT

AGAAACTCAC

TATTGGATAT

TAAGTAAGTT

TGATTCTTTrA

CAGATATTCT

ACATGTAGCT

TAGYJTAGCTA

TGTTGTTTAA

ATATAATCTT

CTGAAACTGA

GAGGAGATGT

GTCAGTGTAT

AGAGTGTTGC

CYITGGGCTAT

TCTTGACAGG

TAATACTCAA

TCATTTTCTG

ATCCCATTTG

TGCTCTCCCT

ATCTGCCTAG

CAGCTTAAGA

TCCTTACCCT

CACAGCCCTA

GGTAAGGCGG

AGTAAGAATT

AGAGGTAAAC

TCTACAAGGT

CTCAAGCCAA ATTGGACTFC TTFTACCCTGT GGCCTCTAAA ATTAAAAAAA ATGTTCTTCC GTACTTCAGA AATAATGGGC CATGGGCCAG ACTAGAACTl AACCACTTTT CTlCTGCTAC CCAGCTATCA AGTATCCTAT TTCATTAGGT ACTTTfAAGT AGCATJTTTAA AGGGTCACCA GGTTGAGATG TAAAAATGGT TTTCAGGTCT TAGGTAC'Fr CTGGGAGCTG TATCACATGT TTGGTrAATT TCTCTGAACG GTTATAGTGA GAATTGAGTT GGAATTAGCC ACATCACTAT CCCAGCAGAA TGATCTTTJ7A ATTAAGAATA ACAACCTAAT ACTCTTAGTT CCTCAAACAT GATGCTTCTC TCTCCTATT GTTATATCTT CATGATAACA AAGAATAAGT TAGAT-rAGGT ATTAATTATT CTrAAAATTA AGATTGTGTC CAT'FrGTTTG CAATTAATAT TTfACACAGA TGGGCACATC TfAGTTATAT AGATA1I7GTT AGAGGTCCTA TTCTAGGATT AGATAAATTG TGTfCACACT TAATTCCATT GGGATAGTGC CTGTAGCATf TAAGAATATC TACTTTATAC TCTrGTACTA CCAGGACATT GCTTAAATCC ATTCTTGAAA TTAGTTTGCT CATCTGAAAA CATCACTGTG AAATGCTrFAG

ATAACTATAA

TGTACAGTAA

CATCAGATTC

ACATACATAA

AAGTTGCCAT

TCATTTACTC

TGGAAATAAT

AAATGTGCAT

CACTC'rrACC

TACTCTATTG

17CACCAGCC

AGTCTTTTCG

GCTTACTGTC

CATCATCACT

AAAAGTAAAT

CCTCTGTGGA

ACCAAACTCT

TGTGTACCTT

TTCTTTGATA

CTCTCTATTG

TTTAACATTC

ACCCC17GT

GAAAAAATTA

TATGTGATAT

AGTTACTGA

GATTATCTTC

CAGATCATGT

TGCTGCCTCC

CCTGTCCCAG

GCTAACTCCT

TTAAAACTGA

TTTTAACT

TTAGGGGTGA

AACATTAAAG

TCAGTGGTTA

CTITCTGAGCC

AATAGCAACT

GACACATAGT

CTCT-TCCAGT

CTTGAAGTCT

TGTCTCATGC

TGGTI=CC

TTTCAGTTCT

TAGATTGATA

TTTGACAAAT

GTrFTCATGCA

CCTCATACAT

TAACTGCTTC

TT1TAAATGT

TATTCTMTC

CAAAGATATA

CAGATGACAC

TCCTTACCCT AAGATTAAGT TAGCACCTTA GACTCTGTCA TCTCTCATGC TAGACCACAA CTCCAGGGCC TGGTAGAATG GCAACTTATT TAAACAAATA ATGATGCTTT TTGATTFGTTT TGTGTTAC17 GTGGTGATTG ATAAAAAGCC AGTTGAAACA CTTGTACA GTTAGCTGAG TTTTTATTCA 11'TAGGCAGA GCCTFAAGCA CCAGTCCATA

ATTACTAGCT

AGTCAGATGC

GTAAATCTCA

TTTTGATCTG

GCTGTCATTG

CAGAATCCTT

AGCTGCAATC

CATGTATATG

AGTGTTGAAT

TAACTCA'TrT

ACTATAGTAG

UTTT[-TGAG

CCTCTGCCTC

CACCACGCCT

TGACCTCAGG

GCCTATATGT

cTTCTATTGT

ATGGGGGTGA

TGTGTGAAGA CAYITCTTTrC TCCTTCCATTF ACAGGTAAAA TrTGGGCTAA TAGCATTTTA AACAGCAACT CTI'ATTT1TCT TTGGCAGTTA GATTTTAATT TATT-FCATTT1 GGGTGTTTTT TTTGAATGTC TGGGTCAGTC TGGGATTATT TATATCCCAT CCTCTGGGGT CTGCCTGGCT TCATTCTYJTT CTGCATGAGA

AATCTTGCAT

TATGTATCAG

TGGTATCCCA

TCCTGTAACA

TCCTAAA1TA

ATGGCGTCTC

ACGGG1TCAA

GGCTAATTTT

TGGTCCACCC

AATAATTTTA

ACATCTGCAA

TITMCTTCA

TCTTTrAAAT TTrATGAAAC CTGTI7ATACA

TAAGATTAAT

TATTTAAGAG

AATTACTMT

CCCTCTTTGC

ACAAAAATTC

CCAACGCATT

TTGATATAGJT

ATTATATTCT

TAGTACCTTT

AGTACTCAGG

CACCCAGAGC

TTGGTAACTG

TTTTGTTCAT

GCGACCT-rTA

CATACATTTG

AAAAATTTGT

TGC'IfTCAGA

ATTGTATTAG

GTTGGTCACA

ATTTGTATAA

GGGATACAAG

TTTTTATTTT

AGTACGAT"TA

CTAGCCCTCA

ATITCCTAACT

GCATITCTTCT

GATCTGATAT

TATGT1TGTG

GAAAAGTTAG

TTGGGAATTA

ATTTAiTA ACTCTGTCAC CCAAGCTGGA

GGGATCGTTC

1TTAGTAGAG GCC1TGGCCT

ATGGGACCAT

GCTGATACAG

AAGTGTAGGG GTTCATCCAA GGAAGGACAG ACCCTAGGGG AGGGTGGAAC

AGTAGTGTTA

TATCCCT[rCT

ACCTTGCTAA

TTTATCCTAT

ACCACAGAGT

AGAAAGTCTA

GTACATAAAG

ACTGTCCAAG

T-GCCTGAAA

CGCCCTCTGC

GGAAGGGGCT AACTrTT'FC TCCTT-rTTCC CMTCCTTTT

AAGGAGAAGI

AGATTCATAT

TTGCAGCTAG

AACAACAGTA

TATATCTTCA

AAAATTCTCA

TGGAGC'ITTG

TGTTCACTAT

YJGTTTGGGT

TCTCAACACC

TACTTGGAGA

TAGTCTATAG

GTrTATATAA

TT-ITTTCAAA

AGGTGGACTG

TAATATTTAT

A'TITAGGCTG

AGTTCTGGAA

GCTTCAAAAA

TITrATAAGG

ACCTCTTAAT

TGCCTTAGCC

ACGGGGTTTC

CCCAAAGTGC

GAATTGAATA

GGAAYJ7CCTT

GTCCTAAAAC

TTTAAAAAGA

T~rCTTGCTTC

TTGTCCTCAC

ATCCTATATC

AACCTCCTCC

GGAAAATTAA

TGGCAAGAGA

ACTGCTTATA

TTTGGGACTG

TATAATTTCT

TTACCAATCA

CTATAACAAA

GCTGGGAAGC

TGGCCCCTTfG

GCACTTATGT

AGTATCACAT

ACCTAACAGT TATATGTCAT TTGTrTTTT GTGCAGTGGT ATGACCTTGG CTCACTGCAG TCCTGAGTAG CTGGGATTAT AGGCGCCTGC GCCATGT17GG CCAGGCTGGT CTCGAACTCC TGGGATTACA GGTGTGAGCC ACCGCGCCCA 'ITTCTTCCTT GAATAGCAAT GACATAGCCC TGTACCTGCG CTCTrCCCTG CCAGTCAGCT TGGTAGCAAC TCCTAGGGCA GGGCTGATCT AGTTCTGAAG GTAGTAAGAA GGAAATGAGG TCTTCTTTAT CTCACCTGCC CCTCCCCTTG TTCATTCGTG CATCCTTTCT GATTCCTC~r AATGGCAGGA AGGTITGTT[ CTTCT-r7ACC TMTTCAGTT TCCTT~CTTGC TTCTCTTGAC ACAGAGATAC TTGGACCAAG AGTAAGATGA GAGTATGGGG GCTGCTTAGC CAGGGTGGCT GATGGAAATC AGAAAATTTA AATTCTCTTA ATAAATGTGA CCAGTTCTGC TTACTGTCCA TCAATCTTAA CTCCAAATTC TGATCAGCGA AAGTAAAGTA TTGAAGTTTT CCTGGCAGTT ATCCCTTAAA CTGGGTAAGG GATrATAAAT CCAATATCAA GGCACCAGTA GATTTGGTGT 'TrGCTGCATC CTCACTTAGT GCAAGGGGCA CATTCATGAG GGCAGAGCCC TCATGACUTA rGGGTGTTAG GTGTCTGGGA GGACACCAAT TJ7CACTTTGT GTTT7AGTCC

ATTAGAAATT

CTAACGAGGG

AGACAGCTCC

ATCACTTCCC

CTTCAAGCCA

1TTATAGAAG

CTAGGTGGCT

AGGGCCATGT

CTGGCAATCC

TGATrAAGGG

AAATAAGGCC

ATAACAACCC

ATTAGAGTT

TATCTCTCAC

TGTGCCGTCT

CTrCAACCTC

CAAAGGCCCC

TATCATCTCA

CATGTGATGT

TAAAACAATA

TCTCTGGAAG

TTAGC~rACT

CATACCTTAC

ACATTCTGAA

CTAAAATCGA

TTAATGTATA

C17GGAAAAA AGTCAAAATA AAACCAGTAG ATTTAATTAA ATCATTCCTT GTATTAATrT CCTGOGGTTG CCGTAACAAG GAATTTTATT CTCTCACATT TCTAGAGGCA GAAGTTCACA GCTIT7AGGGG AGAATATATr TCATATCTTr CTCTTAGCTT TTGGCTFTTCT GTGTCTTCAC ATCATCTTTr TATAAGAACA 'ITTAATATGA CCTCATCTTA ACTAATTATG TCTTCAATAA GTAUTGGGAG TTAGAACTTA AAGCT1TTG GGAGGGACAC TATTTATTCT CAATTAAGTC 'ITGAAATTGG TTTCAAAAAG

TATTACACTA

TTACCACAAA

GTGTGTCAAT

CTCGGTGTCA

CCAGTGATAG

CCCTAT-rTCC

AGTTCAACCC

AGAATATTCT

G1TTTTAACAT ATAGTTCTTT AGCCCCCAAT T1TTT 1T~TTTTTr TT-FTTTTTr T1T[GAGAC GGAGTCTCGC TCTGTCGCCC AGGCCGGACT OCGGACTOCA GTGGCGCAAT 191 CTCGGCTCAC TGCAAGCTCC GCTTCCCGGG FfCACGCCAT ACTACAGGCG CCTGCCACCG CGCCCGGCTA ATTTITTTGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC ATGATCCACC AGGCGTGAGC CACCGCGCCC GGCCTGCCCC CAATTATTTA GTGGCCCTTA GAACTAATTT AATTTCCACT CTAATTCCTA GTATTATTCA GAAAATAAAC ATATACTATT GTATCTGTTG YI'AAATTTTA TTAGTA1TTT AATTGTTTTA TTAAAGAAAG GGCCAAGGCA GAAGGATTGC TITGAGCCCAG GAGTTTGAGA CTCTACAAAA AATAAAAAAA T-fCTCCAGGC CTCATGGCAC GGGGTGGGAG GATGCATTGA GCCCAGGAGA T-FGAGGCTGC GCTTGGACAA CAGAGTGAGA GCTTGTCTAG ATAGATAGAT ATTATCTAAA TAGATAATAG ACAGATTATC TAAATAGATA AGATTATCTA AATAGATAAT AGACAGATTA TCTAAATAGA ATAGATTATC TAAATAGATA ATAGATAGAT AGATI'AGATA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AAAGAAAGAA TGAAAAATGG TCTTCCTrGC TTATATTACC CACACCTTCT

TCCCCTGCCT

ATTTrTAGTA

CGCCTCGGCC

GTMFTCTAT

CTTATGF[TA

CCTACACTTA

AATGTGCCTG

CCAGACTGAG

ATACCTGTAG

AGTGAGCCAT

AGATAGATAA

ATAGACAGAT

TAATAGACAG

GATAGATAGA

CAGCCTCCCG AGTAGCTGGG GAGACGGGGT Y1TCACCTTGT TCCCAAAGTG CTGGGATTAC AAACAGGGAA ATTTATTTGT TATAATGCTT 'FUAGAAATTT GATrTTATTG CCTGCTATAT TAATCTCAGC ACTTTTGAGA CAACACAGGG AGACCCCCAT TTCTAGTTAC TTGGGAGACT GATCAGGCCA CTGTACTCCA TCTAAATAGA TAATAGACAG TATCTAAATA GATAATAGAC ATTATCTATC TAAATAGATA TAGATAGAGC TTGGACAACA AGAAAGAATG GTGCTCATAT YITTAAAGCAT

AAACAGTTGA

AAAATAAAAC

ATCTTGTGTA

ACTCATTCAG

AACAACTITAG

ACTGGGTATT

GGTGATATGA

AGCACTGTAT

GTAAATCAAA

TCTAGGTTTA

GATGGGACTG TTAAGTTATT ATTAGTAGTA TGCTATTTAG 1 ATTTCCTCTT GAATGAGAGA GAAAATTTAA

TCATAACA

AGTCTAGCCT

GGCTGGCTCA

TGACGTCTAT

TAGAGAGTTC

AGTA1TTTCCA

GAGACACAAG

TGGGAGTACA

GCTGATTATA

ATCTTCAAAA

GGTGGGCAGA

AAAATACAAA

GAGTACTTAT

TAAGTAGGTA

AGATAGGTAC

AGGTCAGTGT

TAATCGAAAA

TTGCTTGAGC

AATTAGCCAG

GAACCCAGGA

TTGTTrGGCAT TAAGATGCAA TGTGTTATTT ACCTGCTTTT FAATGAAGTA AAGCTAGAGG kLGTAAGCAAA CAAATAAGTT TCTGTGCCAG GAAATGTTGT ATTATTATAG AATGGTATGA CCAGTGATGA AGTCAGGAAA AGAATAAACT TTGTGCTTYI7 GGCTGAGTGT GGTGACCCAT ACTTTGTTfT

TGAAAATGTA

CTTCGAACAA

GTGTGTCACC

AGGTGCCCTC

TCTTTGGAGG

GGTTTCTTAT

AAATTTGCAT

GGCTGTAATC

GGCCAACATG

AATGCCAGCT

GAGGTCATGC

CCAGiCACTTT GGGAGGCCGA GTGAAACCCC GTCTCTACTA TAGGAGTTCG AGACCAGGCT GAGTGATGGT GCGCACCTGT GGTGGAGGTT GAAGTAAGCC ACTTGGGAGG CTGAGGCAGG AGGATCACTT CACTGCACTC CAGCCTGGGC AACAGAGTGA GAATT'FrCAT CTACCCTAU7 TCTGCTGAGG TGAGGGATC GCCACCATGG AAACCCTTfG GACTCCATCT CAAAAAAAAA AAAAATGATC AAAGAAAGGT

AAAATGGACT

CCTCAGGGCA

ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT ACTATT17CA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC GGAATGGCCC CAACGCGCTG ATAGCCAGTC TFrGcccTTGG TATCAATGTA TTTAAGCTGC TGGCTGGGCG CTGGCCT1T AAGCTGTTCC CC'TIrGCA GAAGTCCTCG GTGGGGATCA ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATTF T-rTGAATATA GGGGTGGACA GCATAAAACC TGTATGCTCA AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCTATTTCTG CACCCTCATG ACTGGTGAGA TGTTGAACAG AAGGAATGGC ATITrCAAAT ATTTTTAATA AGGGTCAAAA TCC11TTGGC TGGCACTGGT TGGATGTGTA ATCATGTGGA TGATTTCACC ACTTFTTCGTG TAATTTGGTC CTACCCAGCA ATGGCTCAAT TTCAAATACA TTAACACTGT GATATCTTGT TCAGGATCAT YITACCAGAAC AAATGTATGA

AGACCTTATC

GATCACAATG

CCGTCCTCAA

AATTGGGATT

CCTGAAGCGA

ATGCCACATC

TATGCCCTTG

AGCTTGAGAA

TATGTGGTCA

ACTTJ7GGCGT

CCTCTGCGCT

CCTTTGGTAA

TTGGCTTCGT

AAAATTCATG

GTGTGCACTG

TTGCCCTCAG

TGCTCTTTGC

AACCGATGTG

CATGTATAAA

CTGCTGCTGT

T17GATCTCCC ATTTC1TTTGC

CTTAGTGTTG

CTGCCATTGA

CATGGTACCC

GAGTUCTACC

CGATC'FrCTA

TGAACATCTT

TGGTTCCCTC

AATTACTTAG

CCCCATAGCT

TACCAGTCCA

AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TFCTGCTTGG 'ITGTAAThI17 T-FCATTTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG TfTTCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA ACCATGAATT CTGTATTrTG TGAGCAAGAA AYI7TAAAAAT TGTTTCCAGT CATGCCTCTG AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT-3' (FRAG. NO: 1738) (SEQ. ID NO: 3009) 5'-GCCACCATGG AAAcccU-TG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA ATCAGTGATA

ATCCTGAGAG

CAGCTTCCTG

TGCCCACAGC

TCGTGGGAAT

CAACGCGCTG

1TTAAGCTC

CCTITFGCA

AGCAGT1GCC

ATCTGGATCC

GGGGTGGACA

GGACTGGTGG

ACTGGTGAGA

GAGAAGTGGC

CCGTATATTG

CTCATGGATT

TGAGCAAGAA

ATACAGCACA AATCTAAGCA GTTACCACTC ATCAACCCAC AGACTAAAAT TACTFTCAGCT ATCATGTGGA TGATTTCACC TAATTrTGGTC CTACCCAGCA TTCAAATACA YTAACACTGT

GGTGGGGAAT

ATAGCCAGTC

TGGCTGGGCG

GAAGTCCTCG

TCCTGGAGTC

TGTCCTTTAT

GCATAAAACC

CTCTTCGGGT

TGTTGAACAG

AAAAACAGT1

AAGAAAACTG

ACATCGGTAT

A'ITrAAAAAT

GCAACTCTGC

TYFGCCCTTGG

CTGGCC'TT

GTGGGGATCA

GTGTTCAGGG

CCTGGCCATT

TGTATGCTCA

TCTATT-rCTG

AAGGAATGGC

TCAGGATCAT

AGACCTTATC

GATCACAATG

CCGTCCTCAA

AATTGGGATT

CCTGAAGCGA

ATGCCACATC

TATGCCCTTG

AGCTTGAGAA

YI7ACCAGAAC

TATGTGGTCA

ACTTJTGGCGT

CCTCTGCGCT

CCTTTGGTAA

TTGGCTTCGT

AAAATTCATG

GTGTGCACTG

TTGCCCTCAG

TGCTCITTGC

ACTTTTCGTG

ATGGCTCAAT

GATATCTTGT

AAATGTATGA

TTGATCTCCC

ATC1TTGC CTrAGTGTTG

CTGCCATTGA

CATGGTACCC

GAGTTFCTACC

CGATCTTCTA

TGAACATCT7

TGGTTCCCTC

GCACAGAGCT

GCACAACTAT

ACTATT7CA

GGAATGGCCC

TATCAATGTA

AAGCTGTTCC

ACAGGTACAG

AATTGCCTCC

'T1GAATATA

AAGATGTAAA

CACCCTCATG

AAGCAGCGTC

'TCATTTAAG

TTTCTTACTG

CTGTAYITTG

AAAGTCTGAT

TTCTGCTTrGG TTGTAATIT TGTATAACGA GATGGACAAG TAACTTGGCA ACCATGAATT TG=rCCAGT CATGCCTCTG AACCGATGTG AATTACTTAG CATGTATAAA CCCCATAGCT CTGCTGCTGT TACCAGTCCA GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC 192 CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT-3'(FRAG.NO:_J(SEQ. ID NO: 2481) 1TTACCTAYJ7 ATGCAT[rGA TATATAAATA AGTATATAAA TGCACACACA GACACAGCAA TGATGGTGAA CAGTCTI'CAT ACAATTATAT GGATGAATCT CATAAAATGC TGAGTTAAAG AAATCAGACC AAAGAACATA TACTGAAAGA TTCTCTCTAT ATACAAAGTT CAAAAATAGG TGGACCAAT[ CATGGTGGTG TUAGAAATCA GAAGAGAGGC TACCTTTGTG GGGAGGGGAC AGTTAATGC CCAGAAGCGG TAAATAAGGA ATCCTCTGGG GAGTGGTAAT GATCTGGATG CTGGCTACAG GATGTGTTGG TTGTAAAAAT GCATT[TTTTT ATATCTAGCT TT-TTCCATGT GTATATTATA CTTCAAAGAA GTTCAGTTAA TAATTITCTCA TGTCACTGTA GAGTAGCTCA GTTAGCCCCA GCAAGCCTCT GGC'FrAATCT TGTITTACCT TAAGCCATCA GTCATTTACA AGTAGGAAAA TTCACAGGGA AAGTTAGAGT ATAAAATCCA GAATGAAGGT TTACTGGGTA AGAGTCTCTC CATTTTCCAA AGCCCGTFJTA TT-rCTrGATT CCAGUTCTTA AGAAGTCTCA GCATrGTGTC TYITCATGT ATCTTACAAG AAGACAGCAT GTdCTTCTAA CACCTGATAC ATTGTATCTA CCAGCACTrG GTAAACAGAA AAGAACCACA TTTTTCTTGT AGGXGAAATT TGGTGCCTAT TTCCTACCAG GCACCAATAA GTGGGACCAA TAGGTGGGAT TAAAGATACA GTAGAAAGTA TTTAAAACTr GCCAGGGGGC AATAGTCTGA AAATAAGTAA ATTGGTGCTA TAGAATGGAA GTTACAGGCT TCTTTCT1T TTCCCACAAG ATCTGCTCCT TGAGCCCCTA

GAGACTI'TTC

AGCCAGGGAA

TGTCTGTTAC TGTFJTCTTCA TTCCTCATCT GCAGAGCCAG CCCTGAGAAG TGCAGACCAA GGCTCTGCAA AGATGTACAA ATGGAAGTCA CCTJTAATAAC CTCTGACTGC TGCGCATAAT

ACATTJTCACT

CAACCATCTG

GCTGGGATAA

TAACTCAAGA

AATACCATTC

CAAATfGACT

ACTATCAACA

ATATCCAGAA

AGGACATGAA

ATCACTAATC

ACTATTAAAA

TAGTGGGAAT

AACTGCCTTT

AGGCGCATGC

CATCAGTGGT

AAAATGAACA

TAATGCAGGA

TGGACACAAA

AAAAAGTACC

CACACAA1TT

GGTTAAGCTA

TAACATTTAT

CATAACAACC

CCATTTGACT

TCCACATTAT

AGCAAATAT[

TCTTCTGAAG

TGTAGTTrCCA

GCTTTTITCTT

GGACATTTTT

T-rTGATTTAA

GCTTAAAGAT

TGTATATAAA

c1TrAACATC

GTTAGTAAGC

ACTGACCAGC

AAAATAATAT

AATGCCTTCA

AGCCGCATGC

TTrCAATAGTT

ATTITACTGCA

TAAAACCTTA

TJTGAACTTTT

G0 ATI7GAGACA

AGGCCACTGC

GCAGTGCAGT

TJ7ATCAGAGT

GAAACCATCT

GTTrAAGCAT

GGGAAGTAAA

GAGGAACCAA

T-rCT-rGGCAA

CTGTTGTGCA

CCCACAAGTT

ACACAAAAGG

GGAAATGGTG

GGAAGTGGCA

TUGCCAGTAG

CAAAAGAGGG GTTAAACAAT GGAACAGAAT ACAGAGGCCA GAAATAATGC TGAACACTGA ATC1TTTGACA AAATCCACAA AAACAAGCAA TGGAGAAAGG ACTCCCTATT CCATAATGGT CTGTCTAGCT ATATACAGAA GAUTGAACCT GGGCCCCTrC TGGAGTAAAG ACTTAAATCT AAAACCAAAC ACTATAAAAA TGGACATAGG ACCTGGCAAA GACTTCATGA CAAGACACCA AATGAAACTA ATGAAACTCT TTAGTTGTAC AACAGATAGT GAGTAAACAA CCTACAGAAT GGAAAAAITT TT-rGCAAACT TCTATAAGGA ATTTAAACAA AT11TACAAGC AAAAAAATGA CAGATGCYTF TCAAAATAAG ACAYI'CACAC ATCCAACAAC ATJTAGAGGAA TACAAATCAA AAGCATAATA AGATACCATC AGTCAGACAA TAACAGATGC TGGTGAAGGT TGTGGAGAAA GTAAACTAGT TCAGCCATTG TGGAAGAGAG TGTGGTGATT CAATCCAGCA ATCCCATTAT TGGATATACA CCAAAAGGAA ATGCATATGT TGATTACAGC ACTATTTACG ATAGCAAAGA AGACTAGCTA AAAAAAAAAA AATGTGGTAC ATATACATCA AGATCATCAT GTCCTTrGCA GCAACATGGA TGTAGTTGGA ACAGAAAGCC AAATACCACA TGTTCTCAUT TATAAGTGAC GAAGGGAACA ATAGACATGG GACCTAC11'G AGAATAGAGG CATAGGACAC TGTGCTTATT ACCTGGGTGA TGAAATAATT ACCTATATAG AAAACCTGTG CATGTACCCC TGAACCTAAA C3TTGTGGTA TAAATCTGAG CATTCATATT AAAATAAAAT TAAGCAAAGA GCCAAGTACC TI7ACACACAT GATGTTTAAT CTTACATCAT ATACAAAAAA CCCTGGAAGA TAGCCTGGGA AAAGCAATAG CAACAAAAAC TTATCTGTAC AACAAAATAA ATGCATCTGA CAAAGGTCTA CCTCATTAAA AAGTGGGCAA CATATGAAAA GATGTTTAAC TAATACCAGT AGGAATGACT AGGGAATGTT TATGCACTGC CCTCAAAGAA TGTAAAACCG TAGAAATTGT FI1TACCGTAA CATGGAATCG TCTAAATGCC CAGAATAGTA TGCAGCCATA GGCCATTATC CTAAGCAAAT AGCTAAATAT TGAGTACACA GTGGGAGGAG GGTGAGGATC TGCACACCAA ACCCCTGTGA AGTTAATGGT GGGGGGGTGG ATTTACCTCA TTAGAGTAAT CTCACAATGA TCTTTAATCT GTCCATTGTA TGTACATATG TGGAAATTGA GCCTFGGAGA GATTAAATGC ATGGGGCATG AGAAACTGGA AGCATCAGGA TTTAAACTCA GTTCTGAATG GTTTTGTAGG CTTTGY[rTTT AGCATGGCCT GCCATGAAGA ACAGGTCCIT TCTGGTGTTT TATTTAAATA TTCAAGATAT CCAAATAACT CUTATTCAAT CTGCAAAGGT AAGTCTTATG TCCTCAGAC CCGCTGAAAG TCCAAATGAA AACCGTGTAT AAATCATTAA AAATAAAfTT TTGATATATA GACACACACA GTrTTTAATA AAAACTAGGA TTGCCTFTAC TTITATAACAT TAATAGCTAA GTGCATGAAC

GCTGTTAAAT

GCTTAGTTGA

GAAAGATTCA

ATAATTTTTA

TCATITTATA

TCAGATATI'A

CATATATACA

GATTAATGCC

TTATCACAGC

TCTGGAGCTA

TYIACTCAA

GAAATTTTAT

CTGTAATTTT

AAATAAAAAC

TGATAAAATC

CCTGAAATTC

TATATATCAT

C1TGAATGA

AGTCATGAGA

GCCTCCCTGG

TGAGCAATAC TAGGTAAATT GCTCTTGYFC CTrAGTTTCT CCACCTCATA GGATTGGTGT GAGCATTAAA TGAGCATACG CATACTGAAC ACAAATATAC GAGCTGTTrGT CTTATTGGGC ATGCAAGGAC CATGTTGGTT TTGTTCCACA TTGCATCCCC GTTGACTATT ATTACTAGTG GCA17AACA AATATCTGTT AGTGTGTCTA ATATTGATGG CATAATGGGG GAAACTCAAA TITCCCTCATC CTCAGTTAT[ GACGTTTT[ TTTTGGCAGG CTGAATTTCC AGCTTCGCAT ATATAAAATA GAGATAGTGA AT[GTGTAAG TTTATCAATA AATAGTAGCT ATTrGTAT YfTGCATAAC CCAAAAGGGG CACCATTCAT GCAGAATACA ATAGGAACCC TGAGGGGACC TACAGTATAC TITTATAGTTC CTCTCAAGGT TGGATGTAUT TGAGGTCCAT AAGAGCAATT GCAGTGATAT TCTCATTTA AATCCGCGGG AAAGAAGACA

GTCTTGTTTG

AAA1TITGAGT GGAGTAGT7C

YITCCTCAT

CTTGTTTTTA

AATGTTFATTA

TACCATCCAG

CCTAAAC'IfC

AAATAAATAC

TAATGATTTA

ATTTTAATCC

TCATCTGTAA

TATGTAGGCC

TCATGT=r

AACCTGGTAT

AAATGAGTGA

CTCTGGAGTC

TGTGTGTGTG

TTCATTCTTG

AAGTATTACA

ACATAAATGG

ATAGATTACA

TAGGATTAAC

GCTATAAACT

G1TrTAAGTGA

ACAGTATGGA

TCAATTTTTA

TTGGACATCA

TATCAAGTGG

ITTTAAAAT

AGATAATAGT

TTTGTATAAA

AATGTGTATG

CATGGTCATT

CAGATCTGTC

AATAGAGATA

ACTTAACAAC

CCTACCACTA

ACAGTGTGCA

AGAAATACCC

AAACAGG'TTU

GGACAACTTA

CAATGTATGG

TATAATATCC

TGTCCCTGGA

AATTATCCCT

AGTAGCTGCA

TGGGACCTGG

TAAATGCC AAGTTCACCA TT=CTAAAA CACAACAAAT ACCCAGTGAG AGAGGGAGAA TGCCTCTGAA TAAGCAAGTT AATGTCAGTA G'FrGTACTGT ATGCATA117G ATGAACAATA TGTCCAATCA GATGAGCAGG ATATTTGGCA ATAACAAGTT GCCTTTGAGG AAAAATGATfr GTTCTTrATC AGCATTACAA AGCTAAAAGC TACGC1TATC ATCACYFATA CTAGCATACC AATGCTGTCT GTGTTTGCAT CTGCTAT"TGT TGATGCCTGG TGCATGAATC AGGACTCCAG TrCCCAGAAC TTTCTTrATGG CCATCATC'rr TAAGTGTCTG GTGAACAGTC ATAGTrTGGT GTCAACCTGG GOGATGGCTA GGG1TTGACT CAGTCGTTAC ATTTCAATAG AGCAGGAAGG GCCTGTAACC TCAGGGAATT T-rGCCAGTTG GTCCACCCCA CTCTCTCTCT CCTGCTCTGA CAGCCTAGAA CAGCACCACA GGTGAGAGAA ATGCAAACCC TAACCAGAGA AGCAGACTCT TAATAGTTCA GOACCACCAC CAGCTT-rTAT TAAAATTTTT AATAACACTC AAGTAT-rGGC 193 AGAAAGAAAT AATCTTGGGT TAACTATAAC TAGAATATTG ACATTTGT11 ACATCAGTTC CCCTGAAGAA GAAAAATACA

ACTCTTCCTC

CTGATGTTGC

GATGTAAATA ACTTCCTTTA GCCTGTAATG CTAGGCTAAT TACATATTGG ATTGTGTAGG GTTTCAGGGA AGAATTCTGA AGAAAATATA GAGCTGAAAT CTGCAGGGTT TAGATCCACA CTGATACTCG TTCTATTATC ACTGTAATGA AATGTYITGT ATTAGTATGT TITTTACACT-[ AT1TGCAAGG CATAAATAGG AATTCTAACA TGTATTGTGC ACAAGCTGTG AGCAGTTTTC AGGAGYFAGG TTCAGGAGTT AATCATCTGG TAGAAGGGTC ATACACAATA GGAAGATGTG ACTATAATCA CACAGAGAGC TGTAGAATTT TAGGCTGGCA GGGTGGCTCA TGGGAGGCCA AGGCAGGCGG ATCAAGAGGT CAGGAGATGG AGACCATCCT GTCTGTACTA AAAATACAAA AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGTG GAGCTTGCAG GCAATCCAAC CTGGGCGACA GAGGGAGACT CAGTCTCAAA AAAAAAAAAA CAGAGGGGTA GCAACTGGGG CTGGGCTGTC AGTCAACTCA GTCAACTCAG GAGATGCCAG TGATGCATf TCATGGCCAA CATTGTCAGT CAGCATCATT GACACAGCTG CAAACGATTC CCCATTAAAT ATGATGTTTC TTGCAATGTT TAAGGGAAAT CCCCTCTTCT GGCTTGCTGA AAGTTTTTFTC T1TCCATTTT TGCAATATTG AGGTGGTTAT ATGG'TfCTC TTrCTCTAATC TG'rrAATATG TTfCTAATGT AAATTCCACT CATATTGCAG AAATAAACCT AAACTGAGCA GCTTCTATAT TTGGTTGCTA TACAGTATTA TGTTTAAGAT TTGTTCACAT ACTATTrC CTTCTTGCCG ATTTITATCT GGUHTTAAA TTAAGc3ATAT GGCAAACAAT CCY[GGCAAG TAATTTTG GGGAATTTGT TTTGGCTAT 1TAATTAAG TTATTCTTAA TGTTTTCTTA ATTAAAAAAA TTACCTACTC TCCAGATIT GTCTA1TrTAT ACCACYTT-C TTYTTCCTC GATGAGTGTC UTATCTFCTT TGATCTTCTC T-rATTCcT-rG TYTcTATTFAA cT-rCTGAAGT CT-FCCTTATG GTTTrATTCTT TCAATTTTTC TCTAACTTCT TAAGTTGGGT TGCTTTTTTA GGATAAGCAT TAAAACTACA AA=I~CCTT GTrATTCTr ATA1TTTCTAT TGTCTAAT-T CTATTCAATT AGAATACT11' AAAGTTTCTT TTTTTAAATT GACAAATAAA AATTGTGTAT ATTTATTGTG CACAGCATAT YJTGTGGAATG GCTAAA1TTA GC~rATTAAT GTATGCATTA TCTCACATAC AGCTATGTGA CTTTTGAACT TATGAGTTAT T7AAATATTT TTAAAT-TATT TAATTTACCT TTTTATTATT AACYI7ATAAC AAGTAGAACA GTTAACCTGT TI1'ATTGACA TTTGCTTCAT AGTCTAFTAT ATGGTCTACT TT-FTFCATG GCTAATAGTFI GAGTAAAGTA CACATATGTC TATGAAATCA AGTGTAATCC TGAATATATT GTTCTAGGTG CTATTATATG TTGTCATGTI' TAATCCTCAC ATAATTAATT CCACTTTACA CATGAGGAGC CTGAGGGTTA AAAAAAAAGC AATGAAGCAA AGATACAAAT GAAGGCCCAC ATATCCTATA ACTAGATATT TFTAAAACTGC TAAATAAAAT GTGCTCCAAT TTCTATATTG ACAGACATAC CGAATJTTAGA AATCTTTGAT GCTTCAGAGT CCACACTGAA ATGTGGAGGC GCCTTCAGTC CACCCACcTT CTCTTFTACTA AATCACCMT CACATACATG AGTCCAAACC CTAAACAAAA TGGGACACCC T17GTGCATAC ACAGAGACAC TGGAAAAGTC CATACAAGTT CTGGAAGCAA GCTTGGGACG GTTTCAGTAG TCAGAAGACA GGTTrCT-rA AUTCTGTGAA CTTCTCCCAC AGTAGAAAGG TGAGGACTTC TAAAGCATGG GTCCTGAGTA GGGGCCACTC TTGCCCAAGT GCACACTACT ACTAGATACT AGAACCCAGA TACAAGCACA GGTCTTCTGA ATTACCATTA TTATACCAGT AGCTGTCATT TATTTAGTGC TTAYI7ATTTG TITTACATGTA TTATACAACT GCCATATAAC TGCCATATGA GGGATGTACC TGTGGAAGAA TCAGCCAATC AGCAAGACAA ATTTAAGCTA AACTATTT TCAGGGAAGA GATCTTGCAG CTCACTGAAA AGGCTGATGG AATAAGTAAA TTAGGTTTTG ATCYITAATfT TATCTGGCCA TGACTGATTT TGTGACAGGT TGTGATCATT CGCCTGTAAT CCCAGCACTr GGCTAACACG GTGAAACCCC GCCTGTAGTC CCAGCTACTr TGAGCCGAGA TCGCATCACT AAAAAAAGTC ATGTTAGATC TCAACTCTGC TCCCCCACAG GAA117ACTCC TGATTATAGA TGGAAGGTAC TCC1TITIAG AAAAATCGTG AATrCCTTT GTGATTTAAT GGTTAGAAAT TGAGGCTATA 1TTTrTATTT ATATTTGTGA ATGGGATTOG TT[AGACTTA TGAAATATTT TTGAGTAUTA CCCAATATAT TAGAGATATT CTTTATGTAC ATAGATGTC ATCTA1T=T TJ7ATfATTTT CTTTTTTCCA GTTTAATTTT TAGCTTGCTT TGCTGCACCC CAAATTrGTTG TTTGGTTT AAAAACTAAC GGCT-rTGAAA TATATGTACA TTATCATTT17 TTGTGGTGAG AAGCATATTG GGATTTTAAG ATGATTCTAC ATCATTGAAA TTACATCTGT AGTAGAATTG A\GAGAAAAAG AGAAATUTAC CACAATTGTA TGAGGCAGCC TAGCTCTACT A1TTTGTAAAG TAAGCATTr AATTCAAGCT

CTTCCTAATG

ACATAGTGAG

TATGAACACC

AGCCCATCCT

TGTGGTCTAT

GTGCTGGAGG

CTAAGAAGGG

AATTAATAAT

CCAGTCACTG

AGCTGGGGTT

TTGGTCCCCA

CCAGCCTCCA

CAGGAAAACC

AAGGGAGGCC

AGGGTCAGAG

TACTAGAATA

AATAATAACT

TTCTAAATTC

CTCATJTGTCA CCATTTrACC GATGAGAAAA CTGGCATAAA ACGTTTAAGT AACTTGTCCA GCTCAATTTG CTCTCAAACT TCAAAGGGAT GGGAAGGACA CTAGAAGGAA TCTTAGATGT TATCTAGTCA GCCTCCTCCC TACTTGTAGC TAYFFITGCA TGTGAATTGC AAGTGAATAT GATATCGCTG GATATAGGAA CAGTGGTTTT AAATCTCTAG TfTTTGGTTTT AATCTATATG CACATCTGTA TTTFCTCAA TGTAATATTT TTTAACTTTA ATGAGTGTTC CTCATAATAG TACT-TTCTAA AGGGATAGTA ATTTCTCTAG AATATTCATT GCAAGTCTGT GCATCATCAA CTATACATTC TGCCTGTrTA TCAAAGGCGA GCCCAGTGGA GAGGCATTr TGGAGACUTC GCGTTAGGGT CTTGGTCAAA ACTGCATTTC TGAAACTAAA CTGATTCAAA TCTACAT1I TAAAAGCCTT AGATGTGGGG CTTTGTGAAT CCACAGGCAA TT-rGGCCACA TCCTTGACTC TCATGCAGAG GAAATATAAC AAAGGAGGGA CTrTCCTACA GTCATATTTA GCCAGAACTG TrGTTTTATA TIrCCTTrC ACCCCCCCCC TCCCTGACCC CAACTAGTCA GAGACCAAAG TGGCCCCACC CTCATCATCA CGCCTGAATA AYTACAT[CA CCACTCCTAA ACCCTCTGAC ACcT-rAATCT TCCCAGAATA GT1TICCCAG AAACTAGAGT ACAAAC1TTTA TAAGCTTFAG CCCAGGTCTC TGCCAAGGCA GTATAACCTG TCCAACATCT GACTCTCCTC CTGGYrTCTA ATTAAACCTG ATCTAGGATC GCCAAGTGAT CTCTTCCTCC TCTGAGCCGC AGCATCTCTG CACAGCCTTA GCTTGCAGTT CAGGGTGTTT ACCrFCCCTC GAACTCTGCC C~rATGTGTC CATAGCCCCT GGTAGTATGT AATTGGTTAA TTGAAGACAA CTGTCCCATG CCTrAAGCCT GTCATTGAAC AACTATTrTG ATCTAT11'TC TTCCTGACAT GAGACATAGC TTAYFCTCTC AAAATFGCTfr TCAAGAGTGA 194 AGTT7ACAGAG

CCTAAGTCAT

ATTACAGTCC

ACATTCTACT

GCT-TTAACTT

TTATCGGGTA

AAAAGTIFTGG

TAATGCTCCA

CTCCAAATCC

CTGGTACATT

CTCAGA17GC C'rrrrCCTAT

TCTCTTATAT

AGATCITI7GA

TGAATACTT

CCTTCACAAT

CTGACTGGTC

CCA'17GTGAT

CTTAGTGAAG

AGAGTCTTTA

AAGAGAAGAT

GAAGATAAAA

TTCTCAGAAC

GTAAAATATA

AAACCATrFGC

GAAGTAATTA

ACATGAAACT

GAGACAGGGT

TTTCT1TrAA

TCCCAGTCTC

TAAGAATTAA

AAAATGGAAC

GTTACACCTC

GGTTTACACT

TCCCCTGCTT

CCTGTTCCAC

CCACAATGTT

AGAATCAGAG

GGCCCTGAGT

GATAT-ffAAA

AAGAAATCCT

ACTTTCYI7C

TATGGGTATA

GCACAATTGT

GATITATACAG

CGGCCAGTCT

GGGGTCAGAA

CGCTATTGGT

ACAGCTAAGT

ATTrGCATAA

CTCCCAGCCA

TGAACCTTCC

CCGTTTATCT

TCTTGCTCAA

CT-I7TTCATC

TTAGATACTA

G'FrGCCCT

CCATAGCACA

CCAGGGATAG

GCAAATGTTT

TGTGTCCTIFT

AGTTGAAAGC CACTCTATCT CTAACTTCAA TACC'TrGTC TAA'IIGCC TCTGAATTCT AGCTrGCACA CTTAGCATAG CCC77CCAGA TGCTGGATCC CTTGCAGTCG TACATTrTTCA CTCTIT=GC TAAACATGCC AGGGGTCAGT TCCGAGGATG CTGAAATCAA 1TFrGTTGTG AATTGAGAAC TGGCTGCCTA

CTTTTGGACT

TCTCTATGGC

TCTATAGACA

AAAATGAGGA

CATCTCTCTA

TTCTCAGAGA

ATAT-fTTGTC CCT-rCACCT-r

ACAGAGOTTA

GCTTCTGCCA

ACTTTCATTA

TAAGTITTCT

GTAGGGTCAC

GCCTACTAAG

ATTAGAGATA

CAAAGTCCTG

TCTGCCCAGC

TTCTGG'TTC

CTCAACCAAG

AGTGTTAAAA

TTATTGTCAG

ACCCACTTCA

ATTAGACACA

CTGTCTAGCT

CAATACCATC

AAATCCAGAT

GCTTAAT1TT

CCAATTTTGC

AAACTCCTCC

GTGTGATGCA

CCCCTACCCC

CCTUCTCTCT

TAACACAGAG

ACCTGCTATA

ATAACTGGAT

GGTACTITATT

AGTTCATGCA

TACTTrTAAA

AAGCAATCCT

A'ITTAAAAAC

CAATTGGTAT

ACCTCTGAGC

AAAAGAACTG AAAATGGCCG

ACCTTGACTG

TGACCCCCAC

ATAAAACAGC

ATITCAAAAGC

GCCGTAACTC

AAAGATCCAC

GTAAGTGGCC

U-GGCACCAC

AACGTGTTCT

GTTTrAATCAC

CGCCTGCCTG

GGGGCAAGCA

TCTCTGGGCT

TGTTCTCAAG

AATACCGCTT

CCATCCCACA

ATTCTTTTAC

CCTCCTGCCT

CCATCTGACC

CCAATTCTTC

CAGCTTACAG

AGGGATTAAC

CCCTGCCCAC

CTCACCCCTA

TTTATTGCTC

AGATCGGGGA

CTATGACCTC

TCTTTTTACT

GCTTCAATCT

ATCTGTGAAC

TGCAGGGATG

GATCCYITCAC

CCACCTCTCC

TGCCTCCTTC

AACTTAAAAC

GACCCCAATA

AGATCTAAAT

ACGTCGGTCC

GTCCCCTCAG

TCTCCCCTCT

CTCAGCGTCC

TTTCATTCTG

GCAAGAGTGT TTGAAACCAA ATCTATTCTA AGTAATMTT TATTCCC'TTT CAGCTCTTTT AAACTACCTT TCGT7ATCTA TTAAACAGAC ATrCAGTAAC ATATGAACTT AGACAAACTA ATATCTCTGA GCTTCAGTFT CTTAAAATTT TATGGCCGGG GATTAAATGC TATGAGGAAT GTAAACCAGA TGTCAGGTAC AAAATGAATT AAAAATACTG GCCGCAAACC CTCTCTAAGA GTTCTCAAAA CATGCTCACC ATAGCACCGA TTTTCTTCTA AATATTTTGT TTCTACCAAA CTI-fATGGC TATTFTCTTCA TATCCACT[ CCCAAACTAA AGAAGCAGCC TTCAAAGCAA CCTAAATACA GGTCTGGGTT TGTATTCCTA GTGGGATGTT GAGGAGGAGT CATGCTGT117 AAATCCATAC TAGTCCCCAG AGGCCAGGCT TCCCGCCACA GAGCTCTTCA GCTTCTCACA TYFCTAGTTC TT7CTCTCTCT TTTT1TTT CTTCTCATGT GCTCACGGGA GCAGAGAAAA TTAACTCCTC TGCCTTAATT ACATATTACT ATTGTTTGAG TTCCTGCCAA CACTACGTCT TTAGAGGCTT ATCAAAAAAA GATAGCTTTC TCCTAAAAAG GGATTTGGAT GCCAAGATAA GYFAACCTA ACAAACITT7A TTAYJ7ATITAT TATTA1fATT CTGTCACCCA GACTGCAGTG CAGGGATGCA ATAATAGCTC ACTGCAGCCT ATCCTTCTGC TTCAGCTCCC TGAGTAGCTA GGACTACAGG CATATGCTAC AAAATAATrA GGGATGGGGT CTTGTTGTAT TGCCCAGGCT CGTCTCAAAC CCTGCCTTTT ACCTCCCTAA FrGTTGGAGT TACAGGCATG AGCCACAGCA 1TTAAAAGA AATCACATTrA CTTACTGTTA TCATCATTAT GGTI'ACTACC TGAAAACACC ACTACCAGAT CAAGCTrCAA ACCAAGATGT CAAGTAAATA CCAAGCCTGC AGGTATACAC CCAGATGGCC TGAAGCAAGT GAAGAATCAC GTfTCCTGCCT TAACTGATGA CAT17CCACCA TTGTGATTTG 'FrCCTGCCCC C17GTGAAAT TCCTrCCCCT GGCTCAGAAG CTCCCCGACT GAGTACCTTG AAGTGAAAAA CCCCCTTTGA CTGTAATTTT CCACTACCCA CCCAAATCCT TCTCCCTTCG CTGACTCTCT TTTCAGACTC AACCTGCCTG CACCTAGGTG ACACAAAGCC TGTTTGGTGG TCTCTTCACA CAGACCATGT GACATTTGGT ACCTCCCTTG GGAGATCAGT CCCCTGTCAT CCTGCTCTTT GCTCCATGAG TGGTCCTCAG ACCAACCAGC CCAAGGAACA TCTCACCAAT TTTAAATTGG CTCTTCTCCA GCCTCTCTCA CTATCCCTCA ACATCTTTCT CCTTrTCAATC CTCCCTTCCC T-TAAITTCAG TTCCTTrCTrTTYTCTGGTAG AGACAGAGGA CCAAAACTCC AGCACTGGTC ATGGACTI'GG AAAGACAGTC TTCCCT7GAT CCTGCCTGAT TATTCACCCA CATTTCAGAG CTGTCTGATC ACTGCAGGGA CTJTAGTGGCA AGTACCACTT TGCCTGGGTG GCAAGCACCA CCTCTCCTGG TGGGGGGCAA GTACCCCCCA ACCCCI1'CTC TCCATGTCTC CACCCTCTCT ACTATGGGCC ACCYI'CCACC CTCCATTCCT CCCTTTTCTC CCTTAGCCTG CTCTTCAACT CACGTCTGAC CTAAAACCTA AATGCCTTAC TTTCTTCTGC CAAACTCAAC AATGGTTCCA AATAGCCTGA AAACGGCACT T-rCAATI7TCT AATTCTGTC GTAAAATGGA CAAATGGTCT GAGGTGCCTG ACATCTGGGC CTCCCTAGTC TCTGTTCCCA ATGCAACTCA TCCCAAATCC TCCU~CTTTC TCCCAACCCC AAGTGTCGCT GAGTCMrCC AATCTTCCTT TTCTACTGAC TCCCCAGACT GCTCCTCCTC AGGTCGCTCC CCGCCAGGCT GAATCAGGCT GCTCCTCCAC CCTATAATCC TTCTATCACC TCCCCTCCTC ACACCTGGTC TGACTAGCCC TCCCCCACCT GCCCAACAAT TTCCTCTTAA AGAGGTGGCT GGTTAATGCT CCTFTTCTT TATCCAACCT CTCCCATCTC AGTTAGTATT ATGAATACCT AGCCCACTCC ATGGCTCATT TGGCAGCAAC TCCTAGACAT GGGGCCAGAA GGTCATCTTA TTCTCAATAT GCAT17TATT ACCCAATCCA TCCAAAAGTT AGACTCCGGC CCTCAAACCC CACAACAGGA CTTAATTAAC TAATAGAGTA GAGGCAGCCA AGTAGCAACA TATYFCTGAG TTGCAATTCC ACCCCAGCCA CATCTCCAGT ACACAAGAAC TJ7CAAAATGC CTAAGCCACA GACCTCCTCC ATCAGGATCT TGCTTCAAGT GCCAGAAATC TGGCCACTGG TGGGATTCCT CCTAAGCCAT GTTCCATCTG TGTGGGACCC CACTGGAAAT GCACCCACTC CCAGAGCCCC TGGAACTCTG GCCCAAGGCT CTCTGACTGA GCTTAGTGGC TGAAGACTGA TGCTGCCTGA TCGCCTCAGA AGCCTCCTGG TAACTCTTAC AGTGGAGGGT AAGTCCGTCC CCTTCTTAAT CAATGCAGAG TTCTC11TCAA GGTCCTGTTT CCCTGTCTT CATAAATGTT GTGGGTATTG CTTAAAACTC CCCAACTCTG GTGCCGATTT AAACAACATT CT1PATACA CCTGCCCAGT TCCCTTATTA GGCTGAGACA YT-FAACCAA ATTATTTGCT ACAGCCACAT CTCATTGCTG CCCTTFCT[CC CAACCCAAAA GTGGCAACTC TCCCCCTACC TTAACCCACA GGTATGGGAC ACCTCTACTC CCTCCCTGGC CTATCCCATT AAAACCTAAT CACCCTTACC TGGGTCAACG CCAGTATCCC GGGATTAAAG CCTGTTATCA CTTGCCTGI1T ACAACATGTC CTITTTAAAGC TCCCCCATTT TACCTGTCCA AAAACTGGAC ATGCCTTACA GGTTAGTTCA AAATI7GTC3Tr GCCTATCCAC GCCATGGTGC CAAACCCATA TACTCTCCTA AACCCCTCCA TAACCCTTAT TCTGTTCTGG ATCTCAAAAC ATGCTr17CTT CATCCCAGCC TCTCTTCACT TTCACT7GGA CTGACCCTGA CACCCATCAG TGTACTGCCG CAAGGCTTCA TGGACAGCCC CCATTACCTC AGTCAACCCA CCTATCCAGG CATAGTTCIT CATGAAAACA CACGTGCTCT CCCTGCTGAT AACCCCAGGA CTGGCAAATT GACTTTACTC ACATGCCCCA AATCAGGACA GOTAGACACT 117CACTGGAT AGGTAGATGC CTTTCCCACA GGGCCTAAGA TCCCTTCTGT CAGACATAAT TCCYJTGGTTT GGCCTTCCCA CCTCTATACA TTACTAGTCA AAGCACGCAA GCAGTTTCTC AGGCTCTTGG TATTCAGTGA TCCTCAATCC TTAGGAAAGG TAGAACTGAT TAATGGTCTT TTAAAAACAC GGAGCTAAAG GCATAGTCAA TAGGCTTT1T TTCATCAAAT TTFTACAGCCT TGGACCCAGA CTCCCAACAT TAGAAAAAGC CTITGCC'flTCA AAGCGTACAA TFFGCCTCCAC TGTGAGAGAA GTGGTCAAGC ATTCCTACAG GCCAAGGAAT GCCCTCAGCC CGGACTGTCC AACTTGCCCA CTCCT-rCCCA GATCTTCTTG ACCATCACAG ATGCTTTTGG GCTACCCACT CCACATTACC ATGGCCAGGC TTCTAAACCC CT-rCTTTTTA GTTATCCCCA TCCCTGACTA TTCCTGGACT CTTTGCCACT TCCTCTCATA AACAAATCAC ACCCTCATTA ATCCCACAAC AGGCTT-rAAA CTGTAAACTC TCCYITACAAT GGATCTGTGC CTTATCAACC TCCTCAATAC CTCCCTCCAA TACTATTCAT 'ITGCACCCTr CCTCAGCAAC TTACCTGGGC AAT11TCYITCT TCATCCATTA CATGTCCAGC TAATCTCCCC CTAAAGTACC TCTTGGTCTG AGGCCACCGT GGTCATTUCT GTCTGATAAT GGACAAGCCT AACCTrCATA CCCCT1TACCG ACCTCACCAA GCTCAG.CCTC CAACTTAAAA AGGACTGGAC AGTACTITA CCACTJTGCCA TTCTCAGAAT TCGGGCCTGT CCTCGAAATG CTACAAGGTA CAGCCCATTr AAGA1TCTGT ATGGACGCTC CT=TTATTA 195 GGCCCCAGTC TCATTCCAGA CACCAGCCCA ACTTGAACTG TGCCCCAAAA ACTTGTCATC CCTACAATCT TCTGTCTAGT CATACTCCTA TTCACCATTC TCAACTACTT GTAAATGCCC TGCCCTrTTr TACAGTGCTG ATTTATACTT 'ITCCTCCAAA CCATCATAAC TGATATCTCC TGGYTTACC TCAAACCGCC ACCCTITAAGT CTCTCTTrAAA GTGGATAGAA GATCTTCAGT GACAAGGTAC ACTCCAATAC TTTCACCCTA ATAAAGCCCT ATTCTTTACT TTTATATTCA CTCTrFATTCT TGTTCCCATT CTTATGCCAC TCTCTACCTC TCCCCAGCTA TCTCCACCAC ACTATCAATC TCACTCACTC TCTCCTAGCC ATTTCTAATC CY!7CT-rTAAC AAACAATTGC TGGCTTTACA ATT1TCTCTT[ CCTCCAAAAT CACCGAGTCC TCAATTTACT CACTGCTAAA AAAGGGGACT CTGCATATTT TTAAATGAAG AGTGTTGT TTACCTAAAT CAATCTGGCC TGGTATATGA CAACATAAAA AAAACTCAAG GATAGAGCCA AAAACC'[TGC CAACCAAGCA AGTAATI'ATG CTGAACCCCC T-rGGGCACTC TAA11TAGATG TCCTGGGTTC TCCCGATTCT TAATCCTTTA ATACCTGT1T TCTCCTTCT CTTATGCAGA CCY7GTGTCT TCCATlTAGT TTCTCAATTC ATACAAAACC GTATCCAGGC CATCACCAAT CATfCTATAC GACAAATGTT TTAAGGGAGG AGACCACCCC TCATATTGTC TTATGCCCAA TTrTCTGCCTC CAAAGAAAGA AGTAAAAATG AAAAGGCAGA AATGAAATCC ACAGGCAGAC AGCCTGATGC CACACCCTGG GCCTGGTGGT TAAGATCAAC CCCTGACCTA ATCAGTTATG TJ7ATCTATAG ATTACAGACA TITGTATGGAA AAGCACTGTG AAAATCCCTG TCTTGTTCTG TTCCTCTAAT TACCAGTACA CGCAGCCCCT AGTCATGTAC CCCCTGCTTG CTCCCCCTGC TTGCTCAATC AGTCATGACC CTCTCACGCA GACCCCCTTA GAGTTGTAAG CCCTTAAGAG GAAAAGGAAT TGTTCACTCG GAGAGCTCGG TYTTGAGAC ATGAGTCTTG CCAATGCTCC CAGCTGAATA AAGCCCU'CC TTCTrTAACT CAGTGTCTGA GGGGTT-fTGT CTGTGTCTTG TCCTGCTACA GTTTCATCTA ACAACCCCAT AATATCACCC CYJ7ACCACAA AATCU-CCTT CAGCTTAATC TCTCCCACTC TAGGTTCTCA CGCCACCCCT AATCCTGCTC GAAGCAGCCC TGAGAAACAT CGCCCGTTAT CTCTCCACAC CACCCCCAAA AAT17TCACT GCCCCAACAC T-ITACCACTA TTCGUUTA TTTTTFCTTAT TAATATAAGA AGATAGAAAT GTCAGGCCTC TGAGCCCAAG CCTGCACGTA TACATCCACA TGGCCTGAAG CAAGTGAAGA ATCACAAAAG AAGTGAAAAT GGCTGGTTCC TGCCTrAACT GATGATATTC CACCATTGTG ATT'TGTTCCT GCGCCACCTT GACTGAGGGA YfAACCTTGT GAAATTCCTT CCCCTGGCTC AGAAGCTCCC CCACTGAGCA CCTTrGTGACC CCCACCCCTA CCCACAAGTG AAAAACCCCC TrrGACTGTA ATTTrTCCACT ACCCACCCAA ATCCTATAAA ACAGCCCCAC CCCATCTCCC TTTGCTGACT CTATTTTrGG ACTCAGCCCA CCTGCACCCA GGTGATfCAA AAGCTTCA17 GCTCACACAA AGCCTG'FITG GTGGTCTCTT CACACCGACA CGCGTGATAA TTATTATATT ACTTTJTAACT AAAACCCTITT CAGAGTCTCG CAGGGAAGGC TGTATATATC TCATAAAATG TFGGGGCCCA CTGGATCAGA CAAGGCCACA AAGGCCAAAG GGAAGTAAAG ATCTCATTAT TTCTCCTAAT AATTTCCCTG TCCTTTGTCA TAAATGGTGG GTAGGCTGTT ATGGTGATGG CAGATTTTCT TTCCATAAAA TGTCCATAAT AGGACAiTTTO AACAGAAGGG AAAAATCAAA TTGCTGAAGT TGAAAGAGGG CAATGCAAAG AACTT'TGGAG AAAGAACTGT ACAGAGAAGT CAACTGGCAG ATGGGAGGAA GTTTAAGGGG AAAAATATAG ATGTCTAAAG AATACATTTA TTCATTCC ACAGTGCAAT TTGGACAAGA AGCCTCTTTC TTGCTTCTTT CTATTCTCAT TAAATCATTA GAGCTCAAGC AATCCT[CTG CCTCAGCTTC CCGACTAGCT AGGACTACAG GTATGTGCTA CTATGCCCAG CTAATTI1T AAAAATTAGA TTTAATJTTG GTGAACTATTr TCTGTAGGAA ACTACAATAA TACAGCCCAG GCACATTGAT CTTGGGTGAA CAAATCAGAA GGAATGAATA ATTCTGTGYI7 CCTGGGACTC TGACAAT117C ATGAACTrGG TACTCTGAGT AAAGCATAGG AGGAGTTATT TCATAAAATG TGGAGCACAA TCATGTGACA AAGATAATGG GATCCCCATT TCATAAATAA ATCTGAAGTT CAGAGAGAGT AACAACTGGC CAGGGTCACA TCACGGAGAC AGAGGCAGGG TTCCCACTGA TGCCTCTGAC TCCTCCCGCA AGCAGAAGTG CAGGGGGCAG AGCTGACCCT GTGCAGTGAA ATTGGAACAC AAGTGAAAGA CT-rCCTGGCT TCTAATCTCA GGATAAGGAC GCCTTAGGAT AAGAACCAGA ATCTTACACC ATGAAAGCAT GAAAGGTAAG TCCCTGTCCC AGGCCC'TrCC AATCTGAGGG CTGAGTTCCT TCAGAGCTCC ATCTGTTCCA ATTTGAGTGA GGAAAAAAAA GGTACCATCA CAATAACCCT AGTCTCAGGG AGGTTAAGAC AAAAAAAGTC TGTGTTTCAG ATTCAGTTCA GTGGGGTAAG CAAGGCAAAT TTCATTCTTG

CAAAGCAGTT

TTTTATGGGC

TCATACTTAA

ATAGGAAGTA

CAAGGT-rTCT

ATATAGGAAT

AGTGTCCATl

GTCTGTGCAC

CAAGATAC

CTTTGAGAAA

TATATTGGCC

CAGCTGTTGA

TATATCAGCA

ACTAGATACT

AAACATATGA

ATGCAAAATlT

TJTAGTAAAGG

TAGAATCTAG

ATTTCTCCAC

TGTIrTCTTA GGAGAAYIT ATATTATGAA TCTTGATITA TGGGATTACT A17ATGTAAT TCCTAAGATC CCTAGAGCTT GAATATAGAA CT17ATTTTT AAATCTATAT ACATCATAAT TACAAGGAGT TGGGTTCCTT GGCCCTGATG TGTTAGTGGA ATAAACATTT TTGTCAGGGT TGCCATGTGT GTGTGCACTG TACACCTCCA GGGGATGTAC CCTAAACCAC ATGAATGTGA 'rrTGCACATC AGTGTACTAT AGGGAGAATC TTrTGCAACA GCT1TIGCTA TAATACAGAA TCTGAGATGT GAAAAGTGTA ATCAYJ7ACCA AAAAAYJTATT CTCATAATGT GTGCAAATTT GTATGAAATC ATGGGACAAG GAGGTATTTC CAGCTAGCTT CTGAAAGGGC TCTATrCTCT CATAAGAATT CATTAGGTGA TATCTGCCCA GGTCATCAGA TGCCATAGAG AAAGAGGGTT TGCTGAAACT GTGCACTGTA TGCTCTTTCT GA'rrATTTrG AACATTCATT TATTGAGTGT CAAGTAATGC CCAGGGATCT GACACAAACT CTGCCCTGAA GGAGCATGTA ATCTCACTGG GGAGAAAACA TAATTTCAAA ATAACAAACT AGGCAAACTA GTTAACACTT AAAAAGCAGG CTTTFATTCAA GCATGTITACA GGGTAACCTT TCAGTAAGAA GCCAGGAAGA GGAGCTCATC ATGGGTTGGA ACTAGTTATA AAAGAAGTGG TGGGGYI'GAG GGAGGCCTGA GATGAAATrT AAAGAATATG GTAAGTGGAT AAAAGGTCTG GGGGCAGGGG AAAGGAGAGC ATTTCATTGT GAATCAAGGA CTGTM~AAC TCTTCCATAT GACATCAAAG AGATGTCACT TGCAGCTAGC ATTTCAGTGA CTAATAATAT CGTGATAAAA GAAACATTGA CTATAAGAAA TAGGAATGGG TCTCATAAAA GGAAACAGCA AAACCCCCAA ACTAAAAAAC AGCGCAGGCT A1TICTCTCT TCTCTCCTTT TGCTTGGCAC TCATGAGATG CTAGGTGTGG AAGTCAGCCA ACTGAAAAAG AGAGOTGOCT GAAGAAGGTG GGGAGGCTGA AGCCAGUTAA ATAGOATGGT CCAATITCACA GACGGCGAGG CTACAGTGCA AATAGGACTC TTUCAACTTG AGCAGGACCC CA1TACTTCA CTGGAGTTAG AAAGAAAGGA GAGCGTAGAC TT-TTGAACT TTCTATAAGA GTGTACCTCC ACAGTATACA GAAGACGACG TGAAATTTGA TCTGCAAGAA AACTGAGTCC ATATTCACAT ATGTATCAAA TTTGCACTTC ATTTAGAAGT GTCTGTCATC AAGTACAGCA CTGAATTGAA ACTGAAAACA AGAGTCAAGA AAGAGCAAAG TCAGCCATCT TTATATrCCA CATGAATCCT TTCCCMrAT GGTCTTATTT GTTTCTCCTC AGAAAAGACA AAAAGCTGAG CTGTATAAAC ACCTGTGGGC TGGGGGTTGA GGGATAAATG AGGGGCGAAA TGGAAGCTGA AGGAACTGYr GGTCAGGTAG AAATCTTCCC AGATGCACTG AAGGAAACAC ACTTCATGTT TGACGTAGGA GGTGCCACCA CACAAAACGT TrCATGGAAG GAT1TAAAGG ATCTCATGAT T1TAGTATT CCAAGAAT TCTTTCACCA AGGGCGATITT AATATGGGTC ATrCATACTG AAAGAAAAAC AAAAGATAAT AAGAGTTTAA AAATTGCAAA ACTTGGAGTG 1TAGTAGTAA AGGTAAATAT TCATTAGAGA TGAGAAGAGG AGCAAGGAAA TGCTTTCAGC TGGAAATCTC AGACAAGAGG CCAGGC1TTA GGAACCTCTG AAGATGAACA AATGTAAGCA AACCCTAGTA GCAGCACTTC TCAGAT1TC ATGTGCTrAC CACTCAGAGA 196

TGGTGT'TAAA

C1TrAGTGAT

GTCTCCAGAT

T-rTAATTTAA

TGGACGGAG

TAGCTGGGAA

CCACATTGGC

GATTACAGGC

GGCATGCTTA

GATAAATTAT

T-rTTTTGTGT(

AGCACCTUTC

TI7CAGCAGCT

GCCCTCCTCT

GACAGTAGAA

TGAAACCACA

ATGAAAATTC

TACCTTTGAC

TI'CAGTGTGA

GTCAAGiGGTC

TCAGCATTGC

GATGTTCATA

AACAGTATAC

CAAGGCCTAT

CATATTCAGA

AAATAATTCT

AGCCTTCCT-F

GCCCCTGAAA

ATGCAGACTC TGATTCAGTA GGTCTGAGTG GAGCCTGAGA TrCTGCAGCC CTAACAAGCT GC~rATGGCA CTGGCGCACA GACCCCACTT GGAGAAATTTF TTGTGGTGCA TACGGTCTTT CTAATGAGTC TGAAGGACAG TGTAGATTGA TTTTTAAAT TTATGTTTAT TTTAAfrTAA TTTATTTATT TATrTATTTT TGAGATGGAG TCTCACTCTG TTGCCCAGTC CGGAGTGCAG GCAGCTCATG CAACCACGGC CTCCTGGGTT CAAGCGATTC TrCCGCCTCA ACTrCCTGAG TACAGGCACG TGCCAGCACA CCCAGCTAAT TTTTGTATTT TTAGTAGAGA TGGGGTTTCA CAAGCTAATC TCAAACTCCT GACCTCATGA TCCACCTGCC ACGGCCTCCG AAAGTGCTGG GTGAGCCACC GAGCCCAGCT GTAGATTGAT TTT-GAGCAGT GGAAAGTCAA GGAATTAGAA AATGGAAAGT GAAATTGGAG AAAATTTAAA CTCATGAAAT AGTGGTGGTT ATAAACTCGT ATCCTGGGAT ATAATTTAAT GAGATGGTAA CACATTTAGT TTAAAGAAAT AAGTGACACT GACACAACTG TCTTATTCTT GGAAAGGACA AGGAGAGAAT GAAATATGGT ATGTCTTC.AC AAAGGGAGAA CCAGATTCTG AGGAGCTGGT CTCATGATGA ACTGTCAGGG TAAACCACAG GCAAATGTGC TTGCCAAAAT AGAGACAAAA AAATGTTTCT GAAAACAAAA TTTCACATAT GAGGTTGGCA TCATATCTTC CTGTGTATCT TGGGTGTAGC TTCTATCCTG CCAGAATUTA ACCAAATGAG GTGATAAACA GAGTCATT GCAGAAGAGT CAAAATAACC CAGCAAGAAA AATGCCCAAG GAGTCATTCA TTCACCA11'C AAAAGCTAAT AGAAATGAAC ACAAACTACT ACCCAAGAAC FrAAAAAAAA AAAAAAAGGC TCATGGTGTT TAGTGTGATA GTATrCAT TTGTTCTAAA AACACACCAT ACTTCTACCC CACCCTTCCT CAGTGCCGTC ACACAATGGT AAAAAAAAAC CACGTrACTG GAAAAGGAGG GTGCCTGGGA CTrGCCACTC TAAGCTGGTA 17GAGTTCTA AAAGCATACG CGTTAAGAGC ATGATTCCTG GATCCAAATG AGTATGGATC CATTTATrGT GACCTCAGGC TATTTTA1TTT CTCTGTGCCT GTTTCTTTAT CAGTAATGAA GACCCTTCTC CCACAGACTT AAAGGCATAT TTCATGATTT AAGACATGTA AACCATTCAT AACATGGAAT TAATATTTGA TAAAGGTTTA TGATTATTGT AACTAACTCT GTCACTrGCT AGAAAACTTA CTTAAT-rAGT TCAACTACAA AAAGAGTTTG AATGTGATAT CCACCAAGAT CCTAGAATTC TGTGATTC~r ATGAATTAAT ACAGCCTrGG TCAATAAATG AGAGCTGGGC TC'rTGCTAG GCCTFICTAG ACCATCTGGT GAAGCATTCA AGACTTATGT TATTGGGGCC TCCAACTTCA ACTCCACAAC TCCTCAATAA GCCATGGGCT CAAGAAAGTT CTGCTCAGTG AATGCTTTCA TAGTCTCACT ACCATACCAC TGCTTACACA A'rrrCCT-rCC TACAGACTGC CTrCCT-rCC

MTCTATAAC

TGCCTTGTAT

CTGAAATCAG

TTCAATAAAC

CTrAGCATGG

TTAAAAAAAA

AAAACAGCTC

ACATCTGTGG

CCATT-FGCAC

CTCATCCAGT

GTCTCTACTr

CAAATAGTCT

AACCGTTCCC

CTGGCAACAT

ACTCTCTCCC

TGCTTTTCTC CATATACCTA AATCCTATCT

CACCAAGCCA

TTTTCTGATT

GGACCAGGCI

AACTATTAAT

TAATTAGC1T AAAATCTAGT1

TGGGTAGATT

GTTTCCTGCC

TAGTAAAGAG

TACCCCTGCC

TCTCATCCTC

CCCCACTGAC

CTTTCTT-rGT CTTTTCATT7

AGGTCCTCTT

AATGACCTTT TCCTTCTTAA TTTT7TCTT-rC TATATTCCTG GACTCCTCTT GCTGTCTCAA TGACTGATTA TAAAAAATCA MTGCTAATA TTCTTCCAGC TGATCTGCTr CCATCTAGTG GTGCCAGAAA ATACTTrTCAC ACAGACATAG GGAGACCAGC AAGACAGAGT AATTAAAAAG CCACTrCTCC T-rCACAGCCA AGTAATGCTC AATGCTTGGC ACCCTI7GTTG CATCCAGGGG TYrCCTTGGCA TTCATTACCC CTCTTTCCCT TAGGTGACTT CCATTCTTAA AGCACTCACA ATGTGAGGGA CCCAAATCCA GAATGATGTG CATACACCCA TCT~ATGT TCCCTTCTCA

ATI'CTTCATA

ATATAGCACC

TCTTAACTCC

GAAAGCTTAG

GTGAACCA117

CAGTCTCTCC

GCAATTAAAA

TCAGTAGGTG

CCAGAGAAAG

AATAAAAAGA

AACATTTTAA

CGTCTGACCT

ATACTJ7ACTG CACACTCTrT

ATTAGATAAT

CCCTCCCTGG

CTTCTCCTGC

AAGCTCAGTA

GAAGTAAACA

TTJTAGCCAAT

GTTCCCTAGA

CCAGGCTCAC

AGCAACCTTC

CATTGGCCAT

CCAGCTAGGT

CAGTITTCCAA

AAACYJ7AATA

TCCTGTGCCT

CAGGTGGTTC

CGAGTFTGAA

AAGCCTTTCC

ACCTCCACTG

AAGAGATGAC

CTGTCTrrGAT GT-rCTCTTGG

CTCCTCTTCC

GATGTTCCTC

7TJ7ATAACAT

TACCATGCTC

AATAATTTTrC

CACAAAAATG

TAGCAATTTG

CAAGGACATC

CGGTAGCCAG

AGAAATCTTC

TCACTAGACT

ATCGTACATC

TGCTJTGTTCT

GTCTGCACTG

CAATGT11TGA

TTFCTCCCTGC

TGGCTCCCAT

GATGGCAGTT ACCTCCTGAA TAGGTCCAAT GAGCCACAGT T-rACCTCCAA AACCTCTCAT CCAGGTGAGA AAGATGATAA T-rTGATTCTr CTCTCTCACT TATCACCTCC TCT-FATTTCA TGAACCCATT CTTACTACTA CTAATAACTG CAAATGCCTC ACTGCTCTGC AGGGTGACCT ATCCCAAAAG ACCTCAAGAT GCCTCATFr TCCCCACYI TGGTTGCCCA AACCAGCATC TCAGTTGTCC AGCTGGGTAC CCTTCCTAAA ATTCCAGAGC CCAGGTGGGC CATCAACYT TGAGCTTCAA GACCAAACTG TCTTTCCCAC ATT-rCTGAAG CAAAACAAGT CTCTTTGAAT TATAAGATGC CAGAGGTAAG GCTACTCACT AAAGCCCATA TCACATGGCT TATACA'FrAG TTCCTFGCA TTCTAAGCAA TGGCCCATAC CAATCCCTTC AGAAATCATC TCACTTCATT TGAATATGTC ACCAAAGTCC TCCTJTTCATA AAGTCACTAA ACCCTAGATA CTGAGAAATA CACATGTCTG CATCTCCTCC CACTGTGCTA AAAAATACTT GCCTCCTTGG GGAAGCTGTA GACAATGCCT GTTAGAGCAA TI'GAATGCAA ATGATAGTAC CCACTCCTGA CATAGCCTCT GTGCTTrGGA CAAAACTGAA CCCATGATCT GGACTACCAT CCGCCAGTTT TAACAGACAC ATTCAGTTAA CAGGCGCCAT CGGTTTTAAT CTGTCTCCCA CACTTGCCAT GTTTAAACCC CTITAGTGAT TT'TATGATCT GGCTrCTGGT TAAGTTTGTG ATTGGTAGGA TCTAGCATTT TAAAGGAAGC GTTTAT~rTTA CTrAAACTCT TTTCCATC TTCA17CTG TTTCTCCAGT AGAAGAAATT GGTAGAAT7C ATGCTCCCTA ATAGTCAATT GAATAAGCAT TTATTCATTT CTCAATAAGT GCTTGTTCAA TTGAATAT7T CTTAAATAAT ATATTTAAGA ACAAGAAGAA CACACCACAA TGTTTTI7AAC CCTCAGAAAA AATITCTGAGG TAATCAGAAA AATCTCCCTYT TACATAAACT GCCCrT~rCT AATAGGGATT ACFITGTTCGT TCATTCATTC ATTCAGCTCC ACTAGCACCA AAAAGCACAG CTCTGAAAGG AAGCTAGTAG ATTTATCACC TTATCTGGTC A1TIGGATGA GGACCCCAGG TAAATAAACT ACTATGGGGT TAATGTGTCT AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAATGAAT CAGCAGATGT GGAAACTCCT CGCCACTAAT AAAAcTrACC TrcTCTTGGA TTCTTGCCT GAAAATAGAA AATAGAGAAA AGGCATTAGC AAAAATTAGA CAATTTIAAAG ITTrTTCAAGT AAGGGAGAAG GAAGACTCCC ACTCTCAAAA CTGTCTTTTrG AAGTATATTA GGTATrGTT AGGTGGACCC TATCTGTGTC AAAGGAGATr TGAGGAACTG GCTI7AATAAA CAGTGGTAGA CACTAATACA GAACAGACAT GTTGATGCAG ATGCCTCCTG AGGTrTCCATrT CCATTCTCCG TGCTACTCAA GAAGACAGAA 25441 'TGCTAAATT GCCTGGTGGC AAGACCCAAT ATGTCCATTC AAGTGTITrAT cccTI'ccCAA TCTGCCATCT CATCCTACCT GCAGATTCTT CCC~rGAGGG ACAGCTGCTA ATACTGTAAA ACTATGTGCC ATTACAGCTC ACAGCATCAT CTCTATGAGA ATCCACAAGA GAATTrCACT TFGGTCTFFGT TGGTAGGAAT TGTGCAGCCT CATCTGAGTA ACTAATGTGT YTTTATCTTA CAAACACAAG GAATATCACA TGGTYrCTCCT TTGACTGGCT GTAAGGAAAC TCAGAGCTAG ATCTGAGACC CTCTCCTACC AAGTATATAA AACTITGTGA CATACATT TGTGCCATAA CTTCAACCT[ GGTTCCAAAT GAYI'1TrGTA 197

CCCTAAGTTT

GCGAAGAGCG

T-rTTCTTACT

GAAAAAAGCA

AAAYITGGCT TrCTTrTTTr ~TT1TGTA CTCAATAAAA CATCAAGCTC AAACAACAAA GCTTCCACAG CGTGGAAGGG GACCCGAGTG GGTrGCCCAA TTTTAATTAA TTTTAATTTG CTATACTGAA CACAYTI7GT ACTGTTCTCA GAATATAAAT AAGTAGATAA CTTAAAAAAA ACTC'FUTGAG CAGAAAGAAT TCAGTGGCTG TAAAGTGGCA TrFCTAGAATC ATCCTACCCA GGTGAAAGCC TAGTGTGTAT TTGAACAGCT ACTTTCTTTT CTAAACTACA ATTJ7CTTCAT

ATTTATTATT

ATTGGCTTCT

CATTFCfTT

CATT-FGGGAG

CTATT-fTGCC

CTGTTAAAGA

GCAATATATT

ACCTGTAGTG

GGCATAATAA

AGCACGTAGA

CTTCTAAAAT

ATTCTGGTTA

CTGTTCCTAC

TGGTCTAACC

GAAGACCAGT

GTATTTTTGA

TGACTAATCA

GTT-FCTGGAA

GCAGGGGACA

CTTCATTGGC

TAAATTCTCT

ACACACCTAA

TTTGTCTTAG

ATGYTFAAA

AAGATGTTGT

GTGCAGTGGT

TCCTGGGTAG

GGTTTCGCCA

AAGTGCTGGG

AGATACCCTA

ACTAGCCTAA

CGGTTTGAGA

CC'TGCTrAT

GATTCTACAA

AGCCCCAAAG

TTGTATCATC CTCATTGGGT CAGTGTTFGCA UTACTGTTTT TCAGCCTGCT GATGACCAAG GCTTCACATA AATATTTTTT TGAGAGAGTT TCATTTTGAA CTGTGTGTYFG GYrrCTGGTGG GATTTTAGAA GATGTATCTG GATITTGGCCT AAAACATCAT GAAAATGATA ATGCCTGGTG TGATAAAATA AAATATTTCC AAGTATTTAG TTCAGGTCCT AATCCTTTAA AGTATTAAAG ACTACTATTT GAAATCTTTr TGCACTTGAG CAGGGGGAAT CAAATCTGAA T[AATTTCAG TTAGGGATGA TGAACCTAAC AGCAATAGAT GAGTAAGAAT GAAAAAGGAA CTAAGGGGGC ATGTGTTCAG TTTCATGCCC GAAATTCTTC CAACCGAGGA AAAAACCAGT TCACAAATCT GACTGGAGTC TAATCTCTGA CTCTGGGTCC TGCTGATATG TGCCCTGGT[ TCCTTATTTA CCAAACAGGG CCAATGGTAG CACAAAATGT GTCTAGATGA GCCCATGCAC AAGGACACAT CTGTTCCYITA TTCCTT-rCCT AAAAGAAAGG AGGGAAAGTC TCCATACTAA GACTACTAGG AAGTGCTAGA GTCAGAAGAT TCATCTGAGG ACAGAAGAAT AGGGGTGAAG GCTCTAGTCA TACCATGCTC TAAATAGTTA CCTGTGCCCT T1TTCTAACT AYJ7AGAACCC AAAAAGCCTA CTCTCTCTCT CTCTCTCTCT GTGTATATAT ATACATATAC ACACACACAT AGACACACAC ACACACACAT AGAGATTTAT GACT1TTAC TM~ATCCTr GTAAATGCCA TTAACTATAT AT11TAGCCTG GGAATGTAGC CATTATrTCT ACCATTGCCT CCATAGGAAA AATACTCTTC GGACCAACCT ACAACTAAAA TCTTTGGAAA GCAGAATCAT ITGTAAGTTG GTGAAAATGG TTTATAAATG AAGACT1Tr TITTUTTT ITTTGAGACA GGGCCTCACT CTGTTGTGGA GCTGTCATGG CTTACTGCAG CCT-fGACCTC CTGGGTTCAA GTGATCCTCC CACCTCAGTC CTGGGACTAC ATGTGCATGC TACCATGCCT GACTAAT~rT TTGTATTFTT GTAGAGATGT TGTTGCCCAG GCTGGTCTTG AACTCGTGGG CTCAAGTAAT CCTCCTGCCT CAGCCTCCAA ATTAGAGGTG ACAGCCAAGG TGCCTGGCCC ACAGATGAAG ACTATTTAAT GTrATCTTAA AGCTrFCCTAC CAAGCCAGTG ATCTT-rGGG GCTTCTGYIT TCTITGTTGG CATAACTGTA CTGCCCGTTA TCTGTTTCCT GTTTGCCCCA CACTGATTCC CACAGCAGTT TTCAAGTTAT TCTTGTACAG AAATGACTCC AAGGTAAAAA ATUTAAAAAC AACCCCTCTA ATT1TTTTAC AAAACAGCCT TAGCCAGCTA ACCCCTCACT ACATGCAAAT GAG'FITGATr CTATTCTfTT ACACTTATTA AAAGATTTTA GAAYFCGGAA ATAAATAGCT TCCUTATTAA GGTGACTfTAC TCCTTAAAAT TATTTAGACA ATAGCCACCT TATCCCAGGG GGCAGTGTGT AATAACCCAC CCTGUTCTCT ATCCGTCAGT TCTGCCATCA TCGCCCAAGG TAGGAAGAAA GACAGGACAA CCGGGGTCAA GATT-7GAAGT CTCAATGGAA AGAATAATCA GTGGTTGGAG AAAACTGTCA TTCTTCTTTrf GCCTTAATGC AGTACTTGAT ACTTATACTT AGTACTGTAT AGTACTFfAGT ACTGTATAAT ACTATAAGAT AGTGAGATTC AATCAGCACA GAATT-rCTAA TAGCAAGGGC AGAGACAT17 TAACTGCTCA GTGCTCTCAG GTTATACATA GCTAATGAAG TTCTTGCATA TCAACAATCC CCACCCCCCT CACACACTTT GTCTTTCTGG ATTGGUTAGA AAACTJTACCT AGCGCCCACT ATTCTCAAAT TTAAATGAAA GATAAGATCA GAGTGGCACG CAATTAGGGA CTGATAAATA ATATYITTGT AATTGCCAGT GTAAATGGAC AGGGGGCAAC CTTTACATAC CATATCAGT GAACAGAATA CGTACTAACT AATTTFGATGG AAGGAAAATr AAAATGACAA TCAACTGAGC CCACAGAAAG GCAACACAGA GCAGUTGGTT AGCAATrGTT TCGAGATCAT CCCTGAACTT GAAACAGGTA TATCUTTTTT T-ITTTTTTTT TTGAGACAGA GTCTCACTCT GTCACCAGGC TGGAGTGCAA TGGTGCGGTC TCAGCTCACT GCAACCTCCG CCTCCCGGGT TCAAGTGATT CT-rCTGTCTC AGCCTCCCGA GTAGCTGGGA TTACAGGTGC CCGCCACCAC GCCTGGCTAA TTTTTGTATT TITFAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT CTTrGAACTGC TGAGCTCATG ATCCGCCCGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG CATGAGCCAC CACACCTGGC CAAAACAGGT ATATCTTAAA AGCTGCCCAA TGTCCATGAA TGTTACAGCC T-FGAATGGTT CTTCCAGGTG AGT'FUGGCCA AATGTGGCAC CATACACCCA AGGCCTGCTG CAGGCTAGTG GGTTGCTCAC AC'FrTAAAGC TGAGACACAC TCATGCCTTA AGGTAAAGGG AGTGATAATC TGGGCAGCAG ATGTTAACTf CTCAAGGCAG TccTccTFrCT cT-rTTCCTCT CCAGTGACGG ATGGTTGGAA AGCATATATG GTGCATI'TGG YJ7AGAGCTGT GGCCTfrGGTG AATAGATACT TGGGAGAATA CATGGGAATT TCTCCCAGGG TTAATGCAAT GCCCATGTGT TGGGAACCAG GTGACTC'rrG AAGAGGTCAG GTATTTGGGA GCAGTGCCTT GAAACCTTAG TGGACATTAG ACCCACTTCC TAGTGGAATT GTAGCATTGA AATCCAAGGC ATGTAGOCTC TTAGAGGACA GAGATAGTGT GTCATTYIT CAGAATTAAT TAAGAGCAGG CCAGGCGTGG TGGCTCACAC CTGTAATCCA AGCCCTTTGG GAGGCCAAGG CAGGCAGATC ACGAGGTCAG GAGATCGAGA CCACTCTGGC TAACACAGTG AAACCCCGTG TCTACTAAAA ATACAAAAAA TrAGCTGGGC ATGGTGGCAC GCTCCTGTAG TCCCAGCTAC 'ITGGGAGGCT GAGOTOGGAG AATAGCTTGA ACCCAGAAGG CGGAGGTTGC AGTGAGCTGA AATTGCACCA CTGCACTCTA GCCTGGTGAC AGAGTGAGGC TCTGTCTCAA AAAAAAAAAA GTATTAAAGA ATTACATAAG AGCAAAGAAC CA'rrAGAATA TCTCACT[AG TTGTrATCAG CCTAGCAAGC TGCCTTGAAG GTAATAGACA T-rTTTAAAAG TITTATCAGAT GAAAAGCGAA AATCAGCCAA CCTGTITTAA TGAAGGTGTG TCCTGGGCTG ATTTACATGT CTCCAGGGAC TGATGGCTCT AGAATGTAAA GCITGGCATC CTGCTTGTGT TGAATCTATC ACATTTAATT TCCTGTGGGT TTCTTT1 TF[C7FTTC AC1TTTAAAGT TGTGTTCTTr TCATGTGAAG TTAAACTCAC ATACC~TTJ7 TTAATCTCCT TGCCAGCCAA ATGATAAATG CCAACCCAGA GAATGCAGTA ACCATGACTG CCACTGGAAT GAAGAGGGGG TrATAATCAC CCTCCTTAAT CATrGAGAAA CTTTUGTCCA ATTCTGAAAG AGAAATCAGT AAGGCACATA GCATGAGACC ACCAGGAT-rA TITTCCT-rAGT CTATCTCATG ATAYITTGACT T1Tn-CCTCC TITACATCTCC CAGTAGTAGC CCAITTrGATG CCAYTrGACA GATGAGGAAA CTGGCATGGG AAGGCCCCTG ATGAGTCTAC AGCATAGGCA AAGACTGGAC CAGCCTTGCT AGTCTAATGC CTACAGAATC TCAATGCCCA GATTTGTGGT TCATAGAGTT CCTGAAAATG CACCTAAAAA TGYTGGCAAG AATGGTCATC GTTGTATT7A GCTCCATGGA CTrrGTTCAAT GACTGGAACT CTGAAACACA GAGAAGAGCT AAAAGCCTAA TACAACTTCA GGAAAAATAA AAGCCAATGA TCTGAACTGG ATAATTCACC AGTCAAAGGA AATCATTAAT GCTT1TACT-r TAAAGCAGTT GTGCAAAAAT AAGCACTTGA TTTACATG CCAAGGACCT GCACTAATTr CTTTCCAATG CAGTAGITAC CACTTCCCTC TACITCCTTC ACGAATAAGT AAAAGGGCAT GTTITAGAGAT ACTCTTGTAA GTGTAAACTA AGTITCATTTG GGAGCCTCTA TTTGAAAATA CTGGTATAAA AAAAAATCTG TCTCCTGATA CTAACATT-rG AAGGAATCTA CTTACA TATTGGCAGA GGGTCTGATT 198 CTATCCTTAG TTCTTCCCAT TACTT-rGATG AACCTTTTCA AGGTGATTTG ATCCCCACAC CCAAATATAT GATTGAGAGA AGGCTCAAGT TCCCAGGAGC TCCAGACAGA AGGTACCTGT TGGCUTGATG AAGATGAGGA GGAAATGAAC ACTAGCTAGG CCT-rAAAGGG AAATGTCTCT GATAGGCCTA ATACACAGTC CTCTGCTAAA GGCCTCCCTG CCTCTCTCTG CTCATCCACT CTACTCCCTG GCCCTGGGCA CGCAGCACAC AGAGATCAGC ATTTCTGACA GCTTCTGTAG ATCCTACCAT TTAAAGACTT TTGTCATCCA TGCAGATAGT CTCAGGAGCA GACACAGGTA GCTATTCTTT CACATGCTAG CTTAACATGC ATrGCTTTA GCACCTATTG CCAGGCACTG TGTCAGGTGG AGGGTATACA AAGATGAACA AGACATGATT CTTCTCATAT ACAGATAGAT TfTGGAGGCA TI'AGCTTAGT GATGATTCAG GAGTATCCAT TATTTGGGGA AGTAGGTGGT CATTAGTGAC CTT-TTACAGG CATTTCAATG GGCTAACAGA GATGTTAGAT TGTAGTGGAA TAGAAGAATG GGTAAAAAGT AAATCAGTGA GTTCAGATTT TAGGAGTTAA GATGGCAAGA GGTGAGAACA AAAAAAGGAA ATGATfGTCA TTAAAGGAGG AGGAAAGACC AGCCAAAGAT T-rTACAGTGA GTrAAGCATA CAAATTTATT TCTAGGCCAC ATAU-CTfAG CAAAACAACA TGTAAATGTT TATGTATGTC TTTCCTCATA TCTGCTCATC CATCAGCTCC ATCGTTAAGA 'FITCAG1T[ CCAGGACAAA CTTACTCACT TTGACATATT GGACTAGGAT TI'GACCAGAT TCCAGATGAT TCACAAATGG 117TTCTTCTT CCCAATTAAC TCAGTTCCTT CTGAGCAGAT GAAGGTACAT GCAGAGGTAA AGCTGAAGCT GGCCAGGGGA TGGCTACAGT TCATGATCCC CAAATCTGGT GCTGATAGAG GCTCACACTG AATCACTTCA ATGAAAAAGA AAAAAAAAAA AAAGACAAAA CAGTATTTCT GAGTAGAGAC CCTCCCTTFGA GCAAAGGATT TTTAGCCAAA GCTGCCTGAC TACATTACTT GTGATATTGC TTCCAGGCTT TATTYITCTrG AGAATGATGG TGGGTGGTGA ATGAGAGATG AAGGCAAGGA AGCATTGAAA GCTGTGGGGA GAGGAGTAGC TACTCCAGGC TGCTGCCCTA GCTAAGGTGA CCCTCCCCTT CTGCTGGAAG TACCATGCCA TATGGCCTCT GCATCAAGGG CTCTTATGGG ATATTCTCAG AGAATCTCTG CCGTTTCATC TGTrCTGATA TCTACCCAAG CATTTTGAAA AACATCCCAA TTCACTGAAG CAAGTCCAAC TTCCGTAAAT TCCAGTAGGT GGGTTGACAG 1TrTATAATT TCAATAAGGG A'TTGATAG CACTTCTAAG AA'rrAAACTA CTTAAACTAA TGCATCAGGA GCATACTTGT AGAAAAGTTA ACCAAAACTT CGTAAGTTCA GATGACATI1G GTTT-FCTCCC ATATGGAGAT AAGGTTGGCA GTTAAAAATG AAAAAAAAAA AAAAACCTAC CTTATTTCAA ACTTGAAAAG ATCAAGAGAT TGTGTTT-G TTTCAGTT GTTATTCTCC TAAAAGT-17A TGCATGAGGA AAAGTAAAAG TGATTTrAAG AATAAGCCAA ATAAAACAAC CAAGAAAGAC CTCCACTACC CTGGGAAGGA AACTGGTTGG TATTAAGTAG GACACCACAT AAAACAGGTG TTATTGAGAG GAGAAGAACC AAAATGTAAC TGAGGTTCAA CAAGACATTA 1TIATGCAAT GGCAATGAGA AAAATAAAAA ACACAGTATA ACCATGCTGT ATTGCTATAA GTCATGTTAC ACACTGGGAG ATGGCTI7CAG GGGTATTTGG T1TTACTTT TTG1GGGA GGT1TTTTCAA AAAAA11TTAG TIrAGAATAAG TCCTITTGAGA AACATCACAG TAGGTTAAAC AAAGTTAGGT TAAA'FfAGGC TCCTAAGTTT GACTTCTCAG CAAACTTCTA CTGAATGTTC TGACTGTAAG CCCAGGATTG CATGACAAAA CCTCTAGTCT GAAGTTACTC ACCTTGACAG GTITGGTTCTG GAGATGACCA GTTTCCAAAT GGTCCACAGG TGGTTTCTTC AATCCCAGTT AAGTTrGTTC CTTCAGAGCA GCTGAAGGCA CACTGTGAGC TGAAGCTGAA GTTTCCCAAA GGGTGAGTAC AGTCCATGGT ACCCAGCTCT GGGGCCTCCA AAGGCTCACA CTGAATCACT TCAATAGGGA AAGAAACAGT ATGGGGAAGA GTTAAGAGGA ACTGACGCCT GGAT7TGAAT CCTAGCCCTG CCACTTGATA ACCATGTGCC T'FrAAACAAG GTTACYI7GAA CCCTCCAACT TCAGTTTCTT CATCTATATA AGAGGAATAA TGAAATTGTG TTATCTTFAT CAAATTGATA TGGAAACTAA ATGTAATTCA ATTAGCATAA GTCAAGGACC YJTAGAACAAA GCCTGACTCA TCAGAAATTC TAAGTAAACA TTAGCTAGTC TTCATATTAT TATCTTCAGC ATTATCTGTA GTGAGAATCC TTAAAGCCAA ATAGGTGTAA CTGGGAATGA CCAGCTTAGT CGGGAAATAA CTATCACATC AGAGCCCCTG AGTCTACTAG AGTAT-rGGGA GCAAGATGTT CAGAGAAAGA GTGGGTCTCC ATAATAAGCC TrCThJTGCAA GGAGAGAATA TAAAAGTCTA GGAAGCATTT TGACCTCAAT TCTGTCTTCT ATTCTAGCTC AGTTCCAGAA TT"TTAACTCT TTTGAMYTG ACAACCCTCT CCAGAAACTG TATCTATfTC CCTGTTCTGA TTGGTGGTAC AATAGGTAAA TTTAAGACTT GGAAATCAAA GfTfCACAT TTTAGACCCT GCCATGCCAT I17AGTAAACA GTACAACT CATGTCTTAT TCCTCATCTG TCAAAT-rTAA GCCATITATTG CTACCTTGCT CTAGAGACTT CAAGGAAGAA TGGACTCAAG GAATCAGAAG AATTTTTGTA TTJTGGAAACT ATATGAGATG AGATTAGGGA GAAACATGGG AACTAAGAGA AAATGTTATC TTTTJTTCATF GATTTAAAGA GTATCTATTA TATATCAAGC ATTIACTCTGG GGCTTGAAGA GCTTAGAT1T CACCCTGTAG GACAAAATGG TAGGTAGAAA TTAATGGGTG GATTGTCATG TATGTGTGAT GTGTTTTAAT TGCTIT-AAT TGATCAGTCT CCCTGTAGTA TGAATAATGT ATTGAGGGG AGCTAATITTA AAATTGTGGA ACTCATCTAA TAAACTATTG CAAGAATCTA GAAGAAAGAT AATGACGGCA ATGGTAGTAG AGTTGACAAG TGGAAGACAA ATTAGAAAAA CACTAAGTTG TAAAAATTGG TAGAATGTTA CCCTGCATAA ATGTTGGGGG AGTrAAGAGA GTCTCATACC AGGGTGCCCA TGTAAATGGT GATTCCACAT ACTGAGATAA GAAATACGAA GAGAAAAGCT GACTGGGAAC AATTGGYITTT ATAGTCT-rTT AAACATCCCA AAGGACATCC TTAGCATATT TGAGTTrCAGA GCTGGAGATA GGCTTATCAG TCCAAAGATC ACATAGATTT GTGAGTCCGC AAAAGTCAGT AAGTTTGACC AAAGGATACA TGTAGAYI7AG AGTCAGAAGA GCAATATACA AAAGACAAAA GCTGAGAAAT TATAGTAGTT TATGGTCCTG GATAAGTGCT CATGAAGGAT CTCAGGAGAA ATGATCACAG GTAGAAAGAA TGAGAAAAGA GTGATATGAG AGAAACCAAG ACAAAGAAAA GTAAAATGTr AAAAATGAGT GAAATAGGCA TACCAATAAT TAAAAATGAG TAAAATAGGC ATACCAATAA CATAAGGGTr AAAAAATAGA GTTCAAAAAT GGGGTGAGGG TAAAGTATTA GGAAGGAGTC ATGGCCCAGG GATCAAGTGA AATGAGTTAG ATCTATAGAT CTAYICAGT TGGT-rGACAT TTAAATGTAT T-GGT1TA ATTCTrATT GTACAAAC ATTrGC'TTTr TAAAAAATTA AATTfGTCCAA T-rCAATTCAG GCTCACAAGC AAGTGCCTCA TATATACAGG CATITTTGTGG ATCCCAAAGA TGCAATGATA AATAGGACAC TTACTGATCT CAAGAAGTTT TCAGTACCAG AGGAGACGGA CAAGTGAACA GATGACTTCA ACATAAGTGG GAGAAATGAG GAAGAAATAT GTGGAGCTAT CAGAACTAAG AAAGCTTCCT AGAAGAAACT GTCTTITGAAC AATGTCTTAA AGATGACATG 1TTTGGCC ATGTGCAAAA TGAGAGAGAA GGCCACCAGC AAAGTCAGTG TGCTACAGAG CACATGTGTT AAGTGTGGAG AACTGCAAGA AGGAAAGGAA CTACTAGAAG GAAAAAGCAA GATACTCT GGGTAACTCA GCCTCCTAAT GATAAATGGC ATAGTFTCTT CCAGACCTTA GAGT7CTAAT TAATCTAACA AGCTCATTAG ATCGTGAGCT TCTTGAGAGC GGGAATCTAC CATGCTAATT CCT1TATGGTA ACCCTGACAG CTTTATCCC AACACTGTGC TTCTTGTGGT ACTCAAAAAG ACTTGTTGAG AAGTGAGTCG AAACTTCATG CTGACTTATG AAATCTTTAC GGAAAGGTAA CAATATTGTG AAAGCAGAGC TFCTGATCA AAACTTCCCA TT-TCTCAGAG TGGCTAGTAT CATMTGT-FC CAACCAGCTr CATGATAAGC TATAATGAUr CCTGTGACTT TACCTAAGAA GAAGCAAAGA AAGGAAAGAG ACTTACCAAA CTGACACTGG GGCCCATAGT ACCCCACATC ACAGTTGCAG GTGTAATTAT TGATGAYTC TACACATTCT CCATGGCCAC TGCATGACCA GGGCTGGCAA GAAGCTAA GGAGGTCAGA AAAAAAATAT TTTAATGTGA TTACATTITA GTACTCAAAG TCATTTCTrT AGACATAGAT AACCTTTTGT CTGAGATGAT TTAAATAATC AGGAAAGGTT 199

TATTTGTAAA

CATAGGCATT

GTGGCATACC

CAATCAT-17C

AATTTGCTAA

TrGGAAAATG

ATTFTTATAT

TGTGAAAACT

TATTATCAAA

CTTGAT'FFAG

GATGCAAGAT

TCCATGGGGT

TCACTCCCTA

TCTTTGTTTC

CCCAGTTCTC

GATTCCTATC

TGTATGGCAA

CAGAATAATG

ATGCAGACTT

ATGAGGAAAC

GTAGAACCTA

GGTYITTCTAG

'ITTAGACATT

TAACTATACA

GGGAGAAGCA

TTTATTTTAC

GTATAATTTT

CTATACACAA

GATATCTAAT

CTACATGAAT

CATTTTGAAC

CCACTGCTGT

TTCATAGCAT AAAAATCATA TATTTGCTTT TGGAATGAAA TTGAAACTCT TGAAATTACT TGCATGCAAT TATTTCTTGG AACGGTAGAG TCCAATTTAT CTGGCTGTTT TGGAATTGTA TGCTAAAATT TTTACGTATA AAATACACTA TTACCAATAC TAATATTCTG TAACACTTAT TGTTTTTAAT GAGTGAGAAG GTTAAATGAT CAATCCCYJTT CT'FATAGAA ATCAAAGATT AAGAGACCAA ATTAACTATG GTTCATTATT GAAGATTTTA CAGAAATATT CATACACCAA

AGCATATAGT

AGGAAACTTA

GACCTGACCT

AAAAAGTCCA

AAAACATCAC

AGATAGTGCA

AAAATTATAT AAGGTITAGAC CAAGAAGGAA GAGGTGATGT GAGCCTAAGT UTCCAACTGG GGCACTGATT GTCTAGCTCT TCCTCTGTAC GGGTATAGCT TTTGTGCACA GGGACAAATC TATATAGAGG GCTAGATGTA TTT-7AGAATG AAATCTGAGT ATTCTCYUAA CCGTGGCCCT CCTGTGTAAC AGAGGGCTGC CTTTAGTTTG TCTTGATATA GATCTCCACG CAGTCCTCCT TGCT-FCYICA GTAAGAGATT TGTTGGYITCC CAGTAGTAAG AACGACTGAA AGGCAGAGTC CTAAATCTGT GTAATTGTCT CGGCAGAATC GTAAGTCCAG CAGTCGGTTC CATGATGTGC ACATAATGTT ACAGCTAAAA AGAACCTAGC AGAGCCTAAG AGTGTATGTG ACCATCTCAG GCACGCAGCA CCACACTCTC TACTTCACAA CCCCAGCTGT CAGCTTCTCC TCCCCTGCCT TTCCTACGTA GATCTATCAT TTTGATGTAA TTACACACCA AAAKFJTCTTA GGAGTGACAC AACCAGAAGC TGTTCTCATC CCCCCACCTT TCCTGAGTCT GAGGCAGCAT AGCCGTCTTG

TGGCAGGCGT

TGTTCTTCTT

CACCCACGTC

TTCTCCAGAT

TTCTAGCCCT

CAGGAAATCT

ACTACTCCAG

GATCACAGAA

CATCGTTCCA

GTTGT-rGGGC

CATATTCCTC

ACTCAATTTC

TTr3CCAGT-rC

GCAAGACATC

GCTGAGCTAG

TAGTTGTTTG

CTATTTGAAA

TTTGCCTGCA

TCACCATCTC

CTATCTTCCG

CGCCTTGTTT

ATGGGTFTTTT

AGTGTGACCT

ACACT-rAGAG

CAGATTTGAA

CAAATTTAGT

GACCTTCTGG CTTGAATATA AGATGCTTT ATCTAAGGTT GTTTATTC TTATTAATTT T17TCTCAAA AYITAUTTCAG CATAYICTT TT-rCTTTGTA GCTGTTAATG ATTTACAACT ATTTACGTAT ACTYTT-AAT CCTGGAATCA TTJTCTTGAAG TAATAAGGAC AGGAAGAACA GTGACATACT Y-rTAAGTAAC CATAGGAAGA ACTGCTTCTG GAAAAGCCCA ATATACCACT TAAAAAGAAC AATTTACAAA GCCAAATGGT ATAGGATTAT AGAGACTCAA CTGATGATGT TTAATAAACA TATGGACCCA TAAACACATA ATTACACAAT GACT"rCATAA TAATATATGG GTGAAATTTA ACCAACATAT

AATTACCGTG

GCCAACACAT

CTCTTTTACA

CAACTCTTAT

GAAATTCATT

TCAAATATGA

CATTCTAAGC

TAATATCATA

ATGTACCTAT

TAAAAAACAT

ATATCTAACT

AGATCATGTT

GGGCTFTGAA

ATGGTATGAT

CACTATTTAA

AGAGTTTTGA

ATCCTITAGTG

GAAAAGAGCA CTAAGT-FTCT GCATGTTTGC TTGGCTAGAG AAAAACCAAG TTCAAAGCTA AGAAGGACCA AAAAATGATA TGtACACTGA ACTATGAATA AACAGAGATT TCTTAATTAA TCTACAGCAT GGGCTATTAT GAAAAGAGAT GF[TACAGAA ACTAGTGGAT ATTTAAGAAA CACAACAGAG CATTGTCCAC CCATGGAAAT ATCTGCAAAT CCTTTGAGGTr GGTGCTTACA GGTAACAGGT TTCTCAGACA TACAGTAAAG AAACAGATAT AA117GATGGT AAAGAGCATC ATAAAATAAA ATGAGCATTC CACTAGAATG CAAGTTCTAA GAGGGAAAAA ACTGTFITGTGT CCTAGCATAA ATTTCACACA TTGTAGGGAC TCAGAAAATA CCTGTJTGTAT ATGTGACACA GTGCAGACAT GGCATAAGGA ATGTGTGAAC GGGAGAGTTA CTGAAAATCC AGGCTAGGGA GAAAGAAGAC ATTAGTTTAC TTAGGAAATG TFGCTGGAGA GTCTTCAAGA ATCAGATATA AAATTTGTCA CAACAATGGG AACCCCCGTC CC11TAATAAG CTCGTATTGT AATTGTAGAA ATGACATTAA AAAAATAGAA AATGAGGTGC TAAATATTTG GTACAGATTG TAAGTACCTTF CATTATTCCT TFIATAATTGA GGGATTTTGT GGGGTTATTG GGATTTGAAC AGGTTAAAAA TAGTGTTCAG GAGTTTCTGG GGAAGAACTA AAGGTAAGAA GGGATAGAAT TAACAGCTCT GTGAAATAAT TTTCCCTTAG ACTATGTATA AATGAATATA AGTAAAATAG ACTTAGCGAT ATATAAATAT CATAACATAC CCCCACAACT TGAAGATGTT CCATAAGTCC CTCTGGGTGC TCTGACATTr GAAATACAAA ATTATATTTA ACTh[CTTAA TAATCAGAAT TAGATGAAAA ATTACTTCAA TI7TGTTCTAT

TTTGGTAATT

T-TTTTAAAGT

CATAATGGGT

TA11TTCT1TT CACCTJ7AAAA

TGTGTGACAA

TTCCAAAGCA

TCAAGAGTCT

ACTTTTTTTG

TCCTATCCTT

AAAGGCTCAC

ACAAGGGTCT

AAAGCCTTC

TCCTCCTGCA

CAAAAATGAA

TTTATI7TTTA

TTTATACCTG

ATI7GTTGCTG

CGCTTTAGTC

CTITTTCTGCT

CY[TAATTAAC

CAATGCCTCA AATACCTAAA TTAATAAAA AGAAATACCT

TATACTTAAT

ACCTGTATGT

TATCACTTCT

CCCCAGAGAC

AGGGTCTGAG

GCCACCTGCC

CATGGCTTTG

CAGGTCCYI7G TITCT1TCAT

CTTCTCTTTC

CTGCTGATCA

GTAAATGACG

TGTGCACATG

CAGGTAGACA

AAAGTCAAGA

AAAATGTTTA

TCTACAACCC

CTTGGTCC31'

CCCAAAGGGA

TTCTCTAACC

TCAAGTTGCT

GAGCTATTAG

TATTGATGCT

AAAAAAAAAA

TTT-rGAGCAA

AGTTAATGGG

TACCCTAGAA

CAGTGTT7AT

AGAGGAAATC

GTTTCTATAT

CAAGAGTTTC

CTCTAGTTCT

GTGTGCTGTG

CAGTCTCACA

GATGTATACT

AAAACACATA

Am-fACATCA

AATCGGTACT

ATAAAACTAT

TATATTTAAT

ATI7AGATAGC

CTGAAATGAC

TGCAGCACAC

CTTAAAGTAT

TGCAAAAGAT

AGCATATCTG

TATTTAAAAC

TATCTGAGCA

TCTGCAGCCC

CTGCAGGTAG

TCCTCCTCCT

CTTAAACCAC ACAT117ATAG TGTCTACTAA CCCTGTCTGA GAACTGATGC ACAGTTTTGT GCCCTGAATT TTTTCTATGG TTAATAITTA CTATGTATAT GTTATAGCCT CACTCTTGAT CAGACACCAG GAAAGAAAAG AAAGTCACAA ATTTCCTGCA CAACATGGCA CATGTATACA AATTTTAAAA AAATTCTATC CTGATTTCAA TAGTATTTCT AGAAGAAAGA TTTCAGGATC CAGAATTGAA ATGGGGTGAT

TCTAAACGTC

ATITGAGCCTC

ACTGCACTGA

CCTCCCCTT-r TCTA117GCCT TCCCTCC117T

TYTTTAGGCTG

TTGACYITAGC

ATGTCAACAG

TCCCTCCCCT

CCCACTGAGA

CTATCCTTCC

CTCTTTCCCC ACCCCT1T7CC TAGACTGGCC GAAAGTAATG TGACTAGATT CTCTCTTCCT TTCCATTCTC CTATGCATCT YI7CCTTACCC TCCTCCTCCT TCACTCATTG TTGTTGCTGT TCT-rCTTCCT CTTCTrTC CTCCTGCTCC TCTTCTTCTA CTTGT7CTTG 'FrC~rGTTT7r TGTITTGGTTC TTGTTCTCCT CTTCCTCCT7 CTCTCTCTCC TCCTCCTCCT TCTrTTCCAC CACCCTCCCC TATCTTTI17C ATAAATGCTA AACTAACTCT TGGCTACCTG TGGTAAATGG CCCTTGGAAA TTGCAAATAC TACAAATCAA AACTGCATTT CAGACATATT TATGATGTTT GCAAAACTTC AGTAGAGCTA AGCAGTGGAC TTJGACTCGUT TCGGYTCCTTr CACCTCCGTC 'TTCCTTGCT CACCACCTAG TGGACGTCCT TGITAGTGGC ACTT1CCTGAA GTTAACCCCT GAAGAGAGCC CATGCTCTCT AGCTITTTCAC CGTGTAGGTT TGGGAGCCTA CAAGTACCTT TAATATTCTT GGACTATAAA ATGAGATGGT T-rTATAAGAC TGCATGTGAA ATTAGGACCC ATATGATGAA GGACAATAAA AAGGAAGACC CACTGATGTG AGTCAATGAG TCAAATGCAA ATCAGATTTG CATrTAGG AAAATAATAA TAACAACAAC AAAAACTCTG AAGCTCAGCG CCCCATATTr ATTATAT~fGT TTAATCT'rrA TAACAGCTCT CTGCTATAGA TATGATTATT ATCCCCAT7C TAAAGAGTCT CAAAGAGGT[ AAGAAACAAA TTCAAAAACT AGCGAAAGAC AAGAAATAAC TAAGATCAGA GCAGAACCAT AGGAGGTAGA GACACGAAAA AGCCTTCAAA AAATCAATAA ATCCAGGAGC TGCATTTTGA AAAGAY[AAC AAAATAGATG GACCACTAGC TAGACTAATA 200 AGAAAGAAGA ATCAATAGAC ACAATAAAAA ATGGTAAAGG GGATATTACC ACTGATCCCG TAGAAATACA AACTACCATC AGAGATTACT ATAAACATCT TTACACAAAT AAACTAGAAA ATCTAGAAGA AATGGATAAA TTCCTGGACA CATACACCCT CCCAAGACTA AACCAGGAAG AAGTCAAATC CCTGAATAGA CTAATAACAA GTTCTGAAAT TAAGGCAGCA ATTAATAGCC TACCAACTAA AAAAAGCCCA GGACCAGATG GATTCACAGC CAAATTCTAC CAGAGGTACA AAGAGGTGCT GGTACCATrC CTTCTGAAAC TATTCCAGAG AATAGAAAAA GAGGAACTCC TCCCTCACTC AYJ7TTATGAG GCCAGCATCA TCCTGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA AAATTTCAGG CCAATATCCC TGATGAACAT CAT1'GCGAAA ATACTCAATA AAATACGGCA AACTGAATCC AGCAGCACAT CAAAAAGCTT ATCAACCACA ATCAAGTTGG CTTCATCCCT GGAATGCAAG GCTGGTTCAA CATACACAAA TCAATAAACA GAATCCATTA CGTAAACAGA ACCAATCACA AAAACCACGT GAUTATCTCA ATAGATGCAG AAAAGGCCTT GGATAAAATT CAACACCCCT TCATGCTAAA AACTCTCAAT AAACTAGGTA TTGATGGAAC GTATCTCAAA ATAATAAGAG CTMTITATGA CAAACCCACA GCCAATAGCA TACTGAATGG GCAAAAACTG AAAGCG'I7CC CTrAAAAAC TGGCACAAGA CAAGTATGCC TCTCTCACCA CTCCTGT[CA ACATAGTATT GGAAGTTCTG GCCAGGGCAA TCAGGCAAGA GAAAGAAATA AAGTGTATTC AAATAGAAGA GAGGAAGTCA AATTGTGTCT GTTTGCAGAT GACATGATTG TATATTTAGA AAATCCCATT GTCTCAGCCC AAAATCTCCT TAAACTGATC AGCAACTTCA GCAAAGTCTC AGGTTACAAA ATCAATGTGA AAAAATCACA AGAAT1TCCTA TACAGCAATA ATAGACAAAC CACGATTGCT ACAAAGAGAA TAAAATACCT AGGAATCCAA GAGAACTACA AACCACTGCT CAAGGAAATA AGAGAGGACA GGGTAGGAAG AATCAATATC ATGAAAATGA CCATACTGCC CATCAAGCTA CTACTGACTT 1TTTCACAGA AUTAGAAAAA AAGAGCT-FGT ATAGCCAAGA CAATCCTAAG CAAAAAGAAC AAACTATACT ACAAGGCTAT AGTAACCAAA ACAGCATGGT GGAACAGAAC AGAGGCATCA GAAATAACAC CACACATCTA AAAGAAGCAA TTGGGAAAGG ATTCCCCATT TAATAAATGA AAACTGAAAC TGGATCCCT CCTFACACCT TATATAAAAA GAAGACCTAA AACCATAAAA ATTCTAGGAG AAAACCTAGG AGACTTCATG ACTAAAACAC CAAAAGCAAC AGCAACAAAA CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT GAAAAT1T GCAATCTATr CACCTGACAA AGGGCTAATA TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA AGAGAGCCAA ATCATGAGTG AACTCCCATT CTTACAAGGA ATGTGAAGGA CCTATTCAAG CAAATGAATG GAAAAACATT CCATGCTCAT CAAGGTAATT TATAGATTCA GTGCTATCCC AACTACTTTA AATTTCATAT GGAACCAAAA AAAGCTGGAG GCATCATGCT ACCTGACTTC GCTGGTACAA AAACAGATAT ATGGACCAAC CAACCATCTG ATCTTTGACA AAGCTGACAA TGTTGGGAAA ACTGGCTAGC CATATGCAGA TTAACTCAAG ATGGATTAAA GACTTAAATG CAATACCATT CAGGACGTAG GTATGGGCAA GCCAAAATTG ACAAATGGGA TCTAATTAAA CAAAGTGAAC AGGAAACCTA CAGAATGGGA TCCAAAATCT ACAAGAAACT TAAACAAATT GGATATGAAC AGATGCTTCT CAAAAGAAGA TCACTGGTCA TTAGAGAAAT GCAAATCAAA TTATTAAAAA GTCAGGAAAC AACAGATGCT GGTGGAAGTG TAAATTAGTT CAATCATTGT AAAACCATTT GACCCAGCAA TCCCATTACT GACACATOCA CACTTATGTr TA~rGAGGCA CACCAATGAT AAACTGGATA AAGATGATGT GGATGAGTTC ATGTCCTrTG CAGGGACATG GAACAGAAAA CCAAACATTA CCCATTCTCA GGGAGGGGAA CATCACACAC TGGGGCATGT ATACCTAATG TAGATGACAG GTTGATGAAT AGTTTATGCA GTCAACAAAC ACCACAATGA GATGCCATCT GGAGAGGATG TGGAGAAATA GGAAGACAAT GTGGCGA'rrr GGGTATATAC CCAAAGGATr CTATTCACAA CAGCAAAGAG GGCACATATA CATCATGGAA GATGAAGCTG GAAACCGTCA CTCATAAGTG GGAGTTGAAC.

CAGGGGATGT GGGGCTAGGG GCAGCAAACC ACCATGGCAC ATATGAAAAA AAGCTCATCA CATGCCAGTT AGAATGGCGA

AGAATGCTTT

CTCAAGGATC

ATAAATCATT

TTGGAACCAA

TACTATACAG

T-rCTCAGCAA

AATGAGAACA

GAGGAACAGC

ATGTATACCT

AGTTTAAAAA

CAATCAGTTC

AATGGGGAAA

TTACAGTGTT

TATAACTAGA

CTACGATAAA

CCCAAATGCC

CCATAAAAAA

ACTAACACTG

CATGGACACA

ATTAGGAGAA

ATGTAACAAA

AAGAAAGTTG

CAAATCCATG

AACGTGGAGC

TTAAAGTATA

TTGGGAATTT

GAACTTGGAA

CACTATACCC

CTCTCTCTT[

CTCA'rrGCAC

AGGCACATGC

GCTCAGGCTG

TCTCACCAAG

GCTCCTGGTT

AACCTCCAAA

TGGTCCAAIT

AACCATTCTC

CTCTCATATF

CCMICCATC

GACACCTCTC

ATITTTTAAG

CAGATTAACA

GAGAGAGGGG

TGAGACATGC

AGTGACCTTFG

ATTTAAAAAA

GAACAGAGGC

GACATGGTAA

TGAAAGAAGT ATCTAGACTT AC'TITTrCT 2TCTAAGAGA TGGGAATGCT TCAAGGAATC CTAGGGTCTA CCCAACCCTC GACTAATTTTr

TAAYITCTGTC

GTCCTACACT

TTCCTCCTAC

CCCT-rGGAGT

CACACTCTTG

CTGTAGCCAA

TTACATATCC

TCAGTGGATT

TITTITTCA

AAATCAGAGA

TTGAAGCTTG

TCACTAACAC

TTCACTGGCT

ACTCCAGAGA

ACTTTGAATA

ATGCCTACTC

CAAACTGAAC

ATAACTCCAT

CAAGTCATAT

GACCGATGGG

GCTCTGTCAC

GTGCCCCT-fC T-rTATITF

TCCAATCAGG

AAACAGCCTA

ATT-rCTJTCTG

TCACCGCT

CCATTTAAAT

AACATCTCCA

TTCTGAATTrF

CCTI'CCAGTT

CCAATGTGTC

CCTGCACGT1'

CCTTAGTCAC

CTCTTGATCA

CAGGGAGACT

AAGTCCTCTC

TCAGGCTAGA

TCCCTCAGCC

ATTITGTAG

CTTTCAGCCA

TTCTCCATCC

TATCATGTGT

CGCTCTTCTGT

GCGAACGAAT

TCCCCAAACA

CTCCTCCAAT

ACTCAGACCA

AACAAATr CTGCTCATGT ATCCCAGAAA ATAACTAGTA AGAGACATGG TTAAGCTGAA CTATGGCAG TGTGAAAGTG CCAGTGCTCC CTCTAATITCT CTCAATCTCT GTGCAGTGGT GCGATCATAG TCCCATGTAG CTAAGACTAC AGACAGGATC TCACTATGTT CACCAATTCC CTGAGACTGC TCATCTTACT TCACCAGGGA TGATTCTCCC TCATCTCCCC GTCTAACCTC ACTAACTTGG TCTAAATTCT GTACAACCAG AATTTAGTTG TTCAATAAGC CTGTAGGGCT CTTCCCACAG AAACTTTTGG AGTTAACTGA GGTAGTGGAA ATATTGCGGG ITr7AGGTGCA CTGGCCAAGT TTAAGCAT[- TGTGGGGTGG G'rFCAGGAGG ATATTTATTA ACAAAGAGTT AAGTTACCTT TCCAAAGGAC TGAGCCCTGA TATCTGTGCA GGGGGAAGCA TACTACAGAA GTGAGAAATA AAGACAGTrrA ATTACATCAT TFCT-FAC1TTT TCAAGAAGAA ACATGTTTfTG CGACTTGAGT CAGCTGCACA GCTAGAGAAA CAGGGTCUTC ACAATGCCTG GGAAAGGAGG

TTCAATTAAT

TTATCTGTCT

AGAGGTAAGT

CTCACTAGCC ACAGAAAAAC AGGCAGTJ7AA T'ITTTAAAGG GCTCCAGCTC 'TfTCTCTTTC TCAGGGGGAG TTGGGTTTTG TTACATACAA CTGAGTT-rCC GCTTACACAT TATfAATTT CrI=AATTC CTGTTCCAAA AGAAGCCAGA TACAAAAGGT TACATGTTGT CTGATTCCAT TTATATGAAA CATATAGAAG AGGTAAATCC ATAGAGACAG AAAGTAGATT AGAGGTTCCC AGGGGCTGAG GAAGAAATGG GGACTAACTG CTI7ATAGGGT ACAGAGTITIT CTTCTGATAA AAATATTG GAACTAGATA GACATYITGT TAGGCCATrC TrFGCATrGTT ATAAAGAAUT ACCTGAGACT TGGTAATTA TAAAGAAAAG ATGTTTAATr GGCTTACACT TCTGCAAGCT TTACAGGAAG CATGGTGCCG ATATCTGCTC AGCTTCTGGT AAGGCCTCAG GAAGCTTFACA ATCATGGCAG AAGGTGAAAG GGGAGCAGGC ATATCACATA GCAAAAGCAG GAGCAAGAGA GGGATGTGGG GAGGTGACAG TCACTTTTAA ACAGCCAGAT CTTGTGAGAA CTCATTCACT ATCATGAAGA CAGTACCAAG AGGATGGTAC TAAATCATTC ATGAGAAACC CCACCCTCAT GATCAAATCA CCTCCCACCA GGCCCCACCT CCAACACTGG GGATTACAAT TTGACATGAG ATTTGAGTGA GAACACGGAT CCAAACCATA TCAGAGATGG TGGTTATACA ATGCGATAAA CGTCACTGGA TrGTACACTT TAAGATGGTT GT1TATGTT GTGTGAACTT CACCTCAATA 201 AAAAAAAATA TTTAATGTAC ATTCAGCCAA AAGAAGATTT CAGCCATITTG ATGGGTGGTA AGGAAAAGAG TGGTTATTAG AGATCGAGTF GGTGAGCA1T ATAAAACCAT CACAAAACCC UTGCCTGCCA TGAGACATGA GGGAAGTACC AGTGAATGCC TGGTCAAAGG ACCACTACCC AACCC'rrCCC TAGCCTACGC GCTCATTGCT GCCAACCAAG GCTGCACTCA CTGCAGTTGC CAGTAGAGAA CTAACTAACT GCCCACCTAC CTCCACAATC TCCT[TACAT[ TGGCATGTAA GCCCCTCU-A CTGTCTGTCA TCTCTCCTGA CCCAACCTTG AT-rTTCATCC CAAATGCTTC ATCACCAAAC TCCCCTCAAT CTI7CCAGTTT CCTGTTCAAA GCCCGACTGC CTCCCTAGGA CATCACFITCC CCTGCAGATC AGCACATACT TCAGGGYITGG AAGGCAGGGG CAATCTTCTC ATTCATCTGC CCTCTTGTAA AACACACACA CACACACACA TGAAGCTTGT GACACTGAGA TAAACCATCT CACTGTCCTC GAUTGGCTTT GGCACCTAGT TCCTGATCTT CC11TTCCCTG ACCATCCATG GCACAACCAA TACCACAGCC CAGATCCTCA 11?GAGCTACC TCCTTCCCTA GGCACAGCCT CAACCTCGAC ACATGTTCAA ACACTTCACT CTAACCAC TGTCTCCTAT TGCAATGCTr 1TTACYFCTA CCTCATTGAA CCTCCAGGCC cTT-rCTCCTT AcYFGU-TGT TTGTTFTATTT GTTTCTTTTT TGTTGCCCAG GCTGGAGTGC AGTGGTATGA TCTCGGCTCA TTCTCATGTC TCAGCCTCCC GAGTAGCTGG GACTACAGGT ATTTTTAYITA GAGAAGGGGT TIGCCATGT TGGCCAAGCT CCTGCCTCAG CCTCCCAAAG TGCTGAGATT ATAGGCATGA UTATTTCAAG TCTATGCTGC ACTATTAAAA CTGCCTTGAC GTGAAAGAGA TCTGAAATAA TCAACCCCCA TCT-rGCCTTT GCTTGGGCCA AGCTATC1TTU GGCAGAAATT TAGTTTATAG AAACTGCCTf TGTAAAACTA ATAAAAGACC ACCAATGAAA GCTAAGGTGT AGATGTAAAC AATTACCAAC TGTTATTCCG ACTCCTGCAG ATAACAGCAC TATCATAGAA TCTGATTGGC TTCAACTGGT GGCTCTACCT GGACCCATCA ACAAGTCCTG ACAAGGACCA TITMCCACAC CGCTATGATT GCATCCCAAC AAATTATCCT TGAAAAATCT TAGCCTTAGA AT-rTTGGGGG TCTCCCATTT GGCTGGCTCT GCATGAATTA AATTCTTTCT 17TATCTGGG CAGCAAACAA AAGGAACCCA TTGGACAGTT AATTGGATY[ TFGTTTAATG AATTTATTCT GTTTTCTTGA GGAATAGGAA AGGTCATGGA ACTGTTGT GGCCCTCAAA TGGAGAGAGG ACCCAGTGCT ATTGAAAGCA GCATCCCTGG CTCCATTACA GATGACCGCA TATCAGTTTA TCATGGGTAA CTATCAGGAC AAATCACCAT TCTATCTCCT ACACAGTTCA

GATATATTAA

AGGTAGAACT

GAAGAACCGT

GTCCAAGGGA

AGATTTATTU

AAGGAATGTG

GGCTCACATT

CCTAAACTGT

CTTrGCCATCT CTGGGATTCC TGTCTTCACC CTTTITCTCCT ACCTCCTTGC TUFGTCATTA TCTCAAGATG ACAATATY[FA TTCTCCACAC CTTATAATG AGTGCCTCTT ATATATGTTT CAAAGAAGAA ATAAAATAAC TCTGCTTCTT ATTGTAGTGA CCTCTCAACT CCTCATGCAA TAAGCACTTC TCATAGTCTT ACGGGACTfC GCTCTCCAAT GACA1TICC TCCACTAGAC AACACCTAAG ACTGTACCGT CTCTAAAGTC TCTTGCAAGT GTATTGCTCA AGTATCTCAT ATTAAACATT TCCTTAYFTC TAACCATCAG TTTTTTT TTTGAGACAG GGTCTCACTC CTGCAGCCTC CATCTCCCTG GTTCAAGTGA GCATGCCACT ACGCCTGGCT AAGA1TIGT GGTCTCGAAC TCCTAACCTC AGGTGATCCA GCCACTATGC CCCACCTGGT TTCTCC'FrAT AAAAATTATA ATAGTGAGAA AATTATGACA ACCTTCCAGA CTGCCCTTAA TTTAAATGAT AATAGCCCTT GGTTAGGAGG ATGAGAGGAG GAGGTCACAA GATTTGCAAC CTTfTGAGAT GTCTTTFTCAG TGGCTCCACC CAGAAGCAGA CAATCAGCAG CAACCATTCC AGGCTGA1TTr CAGTAATAAC CTA'FrGCAGT TCCCATCTTG TAA11TCCTGA

CTCCAAAACT

CCTGAA1TCT

ATCGCCAATT

ATTCTTACAT

CTTAACATGC

TCTGCCTGCC

AAAACCCCGG

ATAAATCACC

TTGCT-FCCAA

GTGTCTGAAT

CTAATTACTC

YTCCCAAACT

ACACTGTTGG CAGATATATC TATTTACAAC TGTGAATGTT TCTCTTTATT TCTTGTTGAA AAGAACTATA TTGCTACAGC CAGTACATAC AGATGGATAG AACACGGGGG GATGTGACCA TCACCGCACT GTGCAAATGA ATGTTACCCA T[GTCCACTT

ACATAGTGTT

GACACTTTAA

TTGGTAACAT

TTGGGTTGGT

AGAAAAGGAA

TAGGACCCAG

TCAGGGCAAA

GTACGCTTGT

GGAGTGCAGT

GCCTCTTGAG

TGGGGTTITCG

AAAGTGCTGG

GTGAATACAA

TCTTTTAGTA

AAATTTITTC

ATGGGGATTG

GCAG-17GATA ATATGGTATA TGACCCAATC AACGGTGGCA AAGCTCCAGA ACTAATCAGC CTATAGTCCT TAAAAAAACA AAAAAATATA TCAGGAACAT TCAGGAGTTT CGTAAAAGCG TCTTGCTTTT GCCCTrFGTAA

TTACCTGTGG

GTGGATT1TT

GGCGTGATCT

TAGCTGGGAC

CCATGTTGGC

GATTACAGGC

AACTAGATCT

TCTYI7CCTTT 'FrAAAGGTT GTTAGGGTfT

TTITTTTT

CTGCTCACTG

TATAGGCACG

CAGGATGGTC

GTGAGTCACC

'FrCCCTfCTG

TTCTCTCTTA

TTTTCAGTAA TTTCCAAACC CACGCAACAT TCGCTCCCAA YI7CAGGGTCC AAGGTTTATA ATAGATCTTA CAAAGATGTA TATCTAAGTA ATGGGCCCTG AGGAATATAT CTCTCTGTGT TTTfTITC TOAGACAGAG CAAACTCCGC CTCCCAGGCT CACCACTATG CCCAGCTAAT TTGATCTCTT GACCTCGTGA ATGCCCAGCA CTTGTGTGGA TAGCATCTGT ACTGTTTACT TTACTTCCTC TTGTGCTATT TTAGCCCTCA CAATGATTCC AGAGATAGAT ATATTAAATT TAGCCTTCTG AGACCACTCA AATACCACAT AGACATCAGG TGGTTGTGCA TCCAAATCAC TCCTACTGAA TCAGAATATT TAATTTGAGG TCTCTCYUTG TTACCATGTA AACACATTCC AAGCTTAATT TTCATTATCT ATGTGTGTGC ACATTAGCAT TCTCGCTCTG TCGCCAGGCT CAAGCGATTC TI1CTGCCTCA T=rGTAT-17 TI7AGTAGAGT TCCACCCGCC TCCACCTCCC TGTI=AAGC TCCCAGGTGA CTATGCATCT CAATAYT=' T11TACACCTC CTTTIAAA TACAAGCCCC ATrTCTGTAA GCAAACTGGC AGTAGTGGGG 11TCCATTTGT GAAAAGTGAT CC1TTTTAYFIT CTATTGACCT AAATAATTGC TGGACTUG CATAACTAGG YTTMAAAGTC TCTACTTCTT ATTATGAGCC AAAATATGCA TTfCATTfCACC CATGCATTGA T-TATTCATT CAATAAATAT TTGTTGGATG TCCACTCTGT ATCAGGAATG TGCTAGGTTC TGGGAATACA GCAATGAACA AGGTAATT TCCCTACCCC TAAGGAACTT AGAGTTI'AGT GGGGAAGACA GACATTAAAC AAACAATTGT GCAAGTAATA ATCTATAATT ATTTAYUACA ATITAAAGGAA GGAAGAGACA TATGGATTAT GAGGOCATTA AAGAGGAGAC CTAGTGTAAG TAGCCAGTTC TCGTGAAGGG ACATGTATTA GTTGGAGTTC TCCAGAGAAA CAGAACCAAT GGTGTGTGTG TGTGTGTGTG CGTGTGTGCG TGTGTGTGTT GGGGTGTGGG GGTGTGGTAT iTTTrATAGA AATTGTCTCA CACAATTATG GAAGCTGAGA AGTCCCATGG CCTGCTGTCT ACGAGCTGAG AACCAGGAAA GCCAGTGGAA TACTTCAAAG TCCAAAGGCC CTGGAACCAA GAGTGCCAGT GTTGGAAGGC AGGAGAAGAT GGGTGTCCCA GCTfAAAAAG ACAGTGAATTr CACTCTT1T GCTCTACATA GGGCCTCAAT GGGTTGGATC ATGGCCACCC ACATTGGTGA AGGCAATCCT CTTAGTCTAC CAATUAAATA CTAATCTCTT TGGAAATACT CTCACAGACA CACTGAGAAA TAATGTTTTA TCAGGGTGAT AGAAATCrJ7C TGGAGTTAAA CAATGGTGAT AGCTGTACAA TCACATACAT TTTTAAAGGG TGCGTTTTAT GGAAAGTGAG =T1ATCTAA ATAAAATTTC TAAGAAAGAG ACTTAACACA GAGATAAACA TAAGCACATT TATFGTCAAC C1TI'ATAGTG TTrATGTCAAA TAGGTCTGAC ATAAGCTTAA ATAAATATAT AC17IAAAAA TTATAAAATA TIJAAGTTA TAATTTrAAAA T-rcTCAATAA AACTCAAACA CAAACCACAC TGGTATTTrCA CACAGCTAAT YUFCTAATGCA GYT-ACATAA ATATTTACAA CAC1TAAACA ATTTCAAAGA AAATAACACT GTATTCCATA CATAGCCTGA TCACAGTAGT TGTICTCTCT TAITI7CCCAG AGTTCTG CCCCTrJTAAA AGAACCTCTG CTGTTCTGAT CCTTATCACA TCTCTGTITT GACTGTTGGC TTJ7GT-TGTfG CCAGTGTTCA GCCAGAACTT CTCTGAAACT TTITfTCAA CACATGCTAA GYI7AATGGAA GTGTAGGAGA GYI=GATTC TCACACTCCT CAAGGCTAGA GCAGCTIGG 202 CAATTACTGA CTGAGAATr TTCATTGCCA GTGATCAACT GAAAACTGGA GATFCCTTrG ATCTGCTTAT AAATAAACAT AAATGCYFGC TCACACAGGC ATTCCTCTCT TCCAGAGCAC AGAAGAAAAC AAATAGGGAA TAACTATTAG ACATCTTCAT TCGTTAAAAA TCTACCAGAT CATGGTGAGT TTCTATrGTG AATTTAAAAT CTFCCATAAT ATACAAGAAT TATGTTTrACA GACAAACATC TTTGTAGGAA TGCAAAGCAC ATCCATCYI' CTGTATrcr-r T-rcCAACAAA AAATTATACC T~rTGTGTGTT TGCAT17ATG CT-1TT1AG TTCAAAACGT TTGGCCTCAT CATCGTGGAA ACCACATATT TCTGAAAAAA TATCTGACAA TATACAAACC TTCCATTCAG CCAATTCTAC CATGTTTTCA AAAAACAACT GTAGTAAAAA CACTCAGAAC TTTATTCTGG GCCTTGCTAG GGGACAATAG TrTCCCTT TGAAATAAAT UTAAAACAGA TGTAACATAA AACAATGAGG GGGTAATCTA GAATAAGTAA C'TM1ACCAT ATCATAGTTG ACAGCATTUA GAATTGTTrAA

CCTAACATAC

GACTCTTTTA

TATCATATCT

GACATTCATA

GGAAGTT

TITTTACTCT

TTAACATCAT

TTTGTTAATA

CAAGThIr= AAGTCCCTAC CACACY[GTA YITGAATGAAG AAGTATGGAA GATTATAATA TATTCAATGC AAGTAAAAAT ATCACAATCC TJ7AAGAACTC TTTAAGAAGC ACTGAATCCC ATAGGGATGA AAGTGATTAA A'FfGTGCATA GTAACCCTCG CACAGAGCAT TCAGTAGGAT TTGCACCATT AACAACCCTC CATGCATTrFG CCTGTGGGCA TTrCAACATCT GTCATrTTT-r TAAGTTATAA TAT17TTAGT CATTTTTC CTCTAAACTC TGGATAATTA TTATTCATTC TTATGACAGC AACTGTGTAA TCAGCTGTCG AAACACTGTG AAGGGCAAAA GAAAGAAAGC CACAAAATAT TGTGTTTCTG TGCCAAGATT TTACAGCGAG CAAGGGAGAG TTAGAAAAGG AATTCTGAGA TTTCAGAGTC TTGGTCTCTT CACC~rTGCT TGGAAGAAAA TATCC1TTTCC CTTCATrAGC CAACACTTTC TTGATCCTGA GAGTAGGAAA GGGAACACTG AGTCTT17CA GUTGAAGGCC GTCCTTGCCT GCTGGACTTT GATCTATTGA AGTGGTGATG GGTGTTGCGG TTTCAGCCAT AAAGGCATCT GGCATAGTAG GCAAGAAGGG CCAGAGACCC GAGGAGAGTT ATCTGTCTCT GTTAACTTCA GTGTATCCCT CTAGTTCCCC AGATGCACCT GTTfCTGTAA ATATAAACAT GCATGTCATC AGAACAC1TA ATATTCTGCA TACTGATCAT GACAACAAAA TGTACCTfCT AACACAGACA CTCTCACTAG GATAGACCAT GTAGGAACAT CGAATTCTAT TCAGTTAGGA CAGTGATGAT GTCTACATAT TATACCTCTG TCAAAACCTA CAGAATATAC AACACAGCAC AGAGTGAATT CTAATGTAGC CTGTGGACAT TAATGAATAA TAATGTATCA ATATTGGCCC ATCAGTTGTA ACACTAATAT AAGATGTTAA TAACAGGGGG AATTGAAGGG GTGGTGGGGA GATATGTTGG AACTCTTTGT GCITrCTGCT CAATTTT[FCT GTAAACTTAA AACCGCACAC ACAAAAAAAG TTATTTTAAT ThTI7TAAAAA GTAYFCAGAG GGACTTGACC TTfCCAAATT CTCTCAAAGC AGGTCGGAGT AGTTAAGAAC ACAAATTTTA GAACCAGACT GCCAGAGTTT GAATCCTGGC TACACCACTT ACTAGCTTTG AGATTTCAGA CAATAC'rr AACTTCTCTG TCTCAT1TC TTCATCTGTG TGATAAGAAA TAAAGTAACA GGCCAGGCCC AGTGGCTCAC GCCTGTAATC CCAGCACTTT GAGAGGCCAA GGCGGGTGGA TCAGGAGYI'C AAGATCAGCC TGGCCAACAT GACGAAAAAA TACAAAATCT CTACTAAAAA TACAAAAATT AGCTGGGTGT GGTGGCAGGC ACCTGTAATC CCAGCTACTC AGGAGGCTGA GGCAGGAGAA TTrGCTTGAAC GCAGGAGGTG GAGGTTGCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT CTAGGCAACA GAATGAGACT CCATCTCAAA ATTAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAATAT AGTACCAGCC CCTATCTCAG AGTTCCTAGC 17AGAAAAAT TCCCAGAATA TAATAAGTGC AATGTAAGGG TCAGCTATCT TCATI'ATTAT TATCTATCAT AAATGAAATT ACACAATAAA GCTAGATCCG TTrTCTTTCCT CTCCTTrCTAC AAAAAATAAA GCAACTTTCC AGAACAATAC CCAGGTGATG ATTTCTCCCC TGCTCCCTCC CTAAGATATT GGCAAGTTTG GAGGGTTCAA GGAGAAACAG AGCATGTAGA GAAGATACCT CTCTCATAAC CATTTGTGAT TTACAAGTCT TACCTGATTC TTTTGAACTT AAAGGATGTA AGAAGGCTfT TGGTAGCTTC CATCTGATTC AAGGCTTTGG CAGCTGCTGT GGAATACATG AGAACACTAG GTAAAGCACT GTCTTCCAAC ATGAAGAGAG AAAAATATGT GGAATGTTCA ATGGCATGCT TTGTATAAGA ATGCAACTTA CCTGGCAGGA ACAAATTTCT TTGCTGCAAA AGAAAAGACA AACAACCATT AATTCAGACT AAATGACTM TAAGGATATA TrAAATCCAG ATACAATATG ACTTAA'FrCA TCAAGTGTTG CAAACTCGAT GCTTCAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT CTGTGGCATC TAGGGTAAAA TGCAAAGTGC ACAGCCATCC AAAGGGCATA GCAGCTTCCT AATGCCAGCA AATAGCTACG GGGTCATCTT GCCCAATTCA GCTCCCAATT TrTCATGAGA AGTCCAAAGT CTTAATTTAA ATGTGAGATT TCCTATTTTG TAAACGTCAG AACTrAACTC AAAAATGTTT TAAGTACTCT TAAACATGTA AGCCAAACAA ACCATGAGTG TAGTCAGATG TGCTTCCATA TTCCTTATGA GAGACTCTCA AATTTAAGCC TGTACTCCAA ATAAATCTCC TTAGGAAGAA TTTTATCCAT TI7TCCTTAGA GTGCTCATCA TGGCAGTTCC ATTGCACAAT TCCGGGAGGC ATCATATAAT TCAACATGAA TAGCACCCCC TGGAGTTGTA CAATATTAGG CACGACTAAC ATT-rTTATYT CCTGAAACAC TrCCCACACT GAGTTGTACT ACTAACTCTT TTCTTAATAC TTCTGCTTAA TTATACTGCA YrFUATCCAG ATTCTAATTA YITGYTTAAAT CAGTAAGCAA GACCATGACT TATCAATGAG AAAGAAATGT ATTTTCAAAA ACATTITrGA AGTACATTCA TAAACTTCCT CACCITCCG TAAGCATTJ7C CGAAGCCAGA GGAGAAATGG TGCTAATGTC AGGAGGGAGA GTCCAGCAGC AGAAAGTCCA GCTACCAAGG GAATGTTGGA CTCAGTGGGA GCTAAGGAAG TAAGAGACGA AGAAAGGTCA TGAGGAAGAA TTGATGTTAA AGTCTCTCCG TCCTGTCCCT Y7GGCCTTTT TITCTGTACAT TCATTACTAG GAGCAGAAGA GCTATCTAGT TTAATACAAG AAGCAGAGAT GTGGCATTAC AGGCCTTTGA GATCTGCTCC AAGCCACCTT TGAAGCTATT TCCACCAT7G GCAGGCAGAA CTCTAAC'rrG CCAAGCTCGT TCACAATACC ACACCACACC TFFGGTTAATA AACACTGCAC TITGCTTGCTC TCTTGCTCTC ACTCCCTCTr GTTTTCCATT TCCCCTFCT CCTCTCCTCT CTCTGTCTCC 3TrCCAGT TGTCAGAA1T CTACCCTTTC CATCAACATG CAACTTCTGT TTT'rrCTCTA TCCCCATACA ACTTAATA1T CACAACT-rGT CAACCTGGiGC GAACMTCTG G'rrTGGATAT AATGAATAGT TGAT1TACTGT AACAAGATAG CTCCCCCTIT 17CT-rTTrAA TCACCAGACA ACCACCATCA ATCAATGCAT CACCTTCACA GGTAGGTAGC AGGCCAGACC AGTGTCCTGT GGCTCCACAT GTCCGAGCTG CAGAGCCATT GAGCGTCCAT CCTTCAGGAC AGGCGAACTT GCACACAGTG CCAAACACGG GCTCCCCACT GCAGCTCATG TTGATCTTTC CCGGAACTGC CAGGCTTGAA CATTTTACCA CTGCAAATGT TAGGTACACA GGCAGAGI7r CAGAAAAATC TACTGGAAAA CTTCCAAAAC T-rGCTTAAAA CAAACCCCTr

CACTCAATITC

TTGATCCATG

AGGGGAATGA

CACGAGAGAG

GCTCT-FCAAT

CGTTGTCCCA

GGAGAACTCA

TCGGGGTTGG

GTCAACAATG AATGTAAAGT GTAAGCGCTA TGGGGCAATC TAGGTTCAGA AACTTTATGA TACCTTGGCA GGAAGGAACC TCYrCTGTCC TAATTCAAAT CCCTCCTCAC AGCTGAAGGC GCACACCTCA CCAAACCCT-F CGGGGGCTGG CACTTTAGAA GTTTGTGC ATCTCCAGCA AGTTCTT[ ATCTfAAAAT AAAATAAAAA CTCCCCTGTG GGGCCACATT GGAGCCTT= CTTAGTTTTC AGCATGTAGG AGTATTTGAC CTGTACCCTA ATTGTCCCTG AGATGTGCAC ACAAGAGGAC TTGTAGGTGA TGGACAGCAT CGCATCTCAC ATACGTTTCC CAAGGTAACC CAAAGACTGT ACCTTCACAT GGATCCCTrC AACACAAAAC

AAATTAGGAC

AAAAAGTCTG

TCAAGYI7GAG AflCTCCAAT

AGCTGGAACA

AAGTTCCCAA

GTGGGCTTCT

CCTGCTCACA

GTAGCCTCGC

ATTGCAGTGG

CAGCTGGACC CATAACGGAA ACTGCCAGAA GCACTAGGAA GACAATTCAT ACAAGGCTGT GCACTGGAAA GCTGAGACAT CAAAATGATG GTCAGAAAAT 203 AACTAGAGAG TACTTGGCGT flGTTGAGTG AACCCAGTTC ATTCAAGCAA CACTTGGAGA ACTGAAGATr CTTTATAATfr CCCTGGACAA ATGGGAAGAT GGCTGTGT'rr TCTT-rGAAT-r TCAGCCCCCT CACTGATCAT GGCACTAATT AAAAGACTAA TTAATCAGAA CATTAGTTCC TGAGCACTGT TCTTCTAACA CACAAAATAA ATTATGGTCC AAGGAAAGAT TrCACGCAGT CTGAGGACAA CATATGGGTC ATGGATGTTT ATAGATGGTG CCAAAAAGAA AGAAAAGAAA GCACCCCTAT AAAATT-rGTC TGrMTGCAG TTTGGTTMT GTG'FrATGTT TTGCTACTGG AAATCATTCT GTGCTGGCTT TGGCTAGGAC AAGGCCAGTG CCTGATAGTA AAAACTGCTf GTTTTCAATA TCCTTGCTCT CACTTTAAAG TGAATTAAAA TTrACTGCTT ATATATGCAT CAATACTATC TCTGTAGCTG ACACCATGCT TGAAACAGTC TCATCACTGC TAATTATGAG CCATTJ7CAGA AGACAGGTGT GATGAGAGTT TTACA'FUCAA ATCATGTTCT CATTATTCTG CTIrCCGAAT TTTCTAATAT GATrCCTTTA GATTAAGAAT TCTGTCTAT[r CCATGCTAAT GTCTACAAAG TrTTATCAGC ACATCACAGT TAAAAAAAAA CAGCAAAGAA TTCA1TCTTA ACACATATGA TCCTJTTCCCT GGCCAAACAT TAGTTCTY[T AAATGAATCT CAAAGATACG AGGGTTGCTC ATCAAATCTG ATTTCTATAG TTAAAGTGGG TATTGGTTTT TTTTTTCACT

GTCCAAGTTT

TGGGATTTGC

TCCTCACAGG

AGCCATTCTG

GGCCTAGAAT

GAACAACTCT

GGCTCCCAIT

TTTGGAAAC

AAGAGCACCA

GGAAGCTGCC

AAGCTITAT

AATCTATGTT

TACTGACATA

GCCTCTGGTT

AAG'FfAGTCC

TTTATGFTT

GAAGATGGTT

TGTGTCCACT

TGAAGTTGCA

AGGCTGGCGG

TAGCTTGCCC

ACCTTTACAC

AGTTrCAAATC

ATTCCACGAA

TGAATTI7TAC 'I1TCAAAGGGT

TCFTITCAT

ATCA'TfACG

CGTAGGCTAT

CAGAAAGATA

GTTCTFTAAG

GCCCTTGAGT

GGATGATTTG

ACGGCCCTGC

ATT-FCCAGTA

GTFGGCTTCT

CT-rCTTCACA

CCCATTGGCT

AGAAGAATGA

AGATCCCAAA

GGATATTCTA

TGAGGTAAAA

TCATTTATTT

AAAGTATAAA

GGTGCATTCA

AAGGTGAACT

ATGTCACAGC

TGGGTTGAGA

CGTTGTCCCA

GTCAAATGTA

GGATTTGTCA

TCTTTTCACT

GTCCTATGTC

TCTTTTCTGA

ATTTAAAAAA

TAGCCCATCA

TCGAAGGATC TCAAGCTTAC CTJ7CACAAAC ACCTGGGCTG GTCCCTGCAA CATGAAGCCT CTCCAGCAGG GGAATGGCTG CACCTCACAG TGTAACAAAT ATACGCATTG ATATTAGGAC GAAAGAATGT TCACAGTAAG TCTCCATGTG ATTCCCAGAT GAGGTACACT GAAGGCTCTG CAGGTTGTGT TCCATGGGAA GC'rrCCAGGG CAGCATCACA CTCAACCACT GAGGATTTTA TCCTATTGAG CTGGGTGCCT AACAGAGTGA AA17CTTAGG GACATGCACA GCCAGAATAA TTTCCACTrr GCCTATGCTG AGTGGTCTCT AATAGATTCC AGATTIAGGAG TTATGACTAG GAGCCTGAAG AACTGATTTT TCTTT[TTG AAATTAAGAG AGAAAAAGAG ATACTAAGAC TGCTTGACTA TCATGGTCTT CATGGCTTGG AAAAGTTAAA CAGGGAAACA AGATGAGAAA TCCATTGAGA TTrCTAGAGC FATGGTCTCC CTTACAAATC ACCAGAGCCT CAGAAACACC CATTTCAAGC ATAGAATAAA AAAACCTCTC TCAACCCAAG CAGGTACTGG GTTGGCAATA TACATTGGCT GAGAGAACAA ATTGTATTAA AAACAAAAAC AAAAAAAAAA CTTTCCCTGA AGTTTTGAAA ATGTAAGTTG AATCAAAAAA CAGAAGCAAT GAGGGATGAG TTACAGAACG FITCTGTGCAT TCTCAGAGGG ATTTACCATT GCAGGCTGGA ATAGGAGCAC TCCAUTCTCC AGAGGACATA CACTGCATGG TCTCCATGCT GCTTGGCAGG TAACCCCTAT CACAGCTGAT AGAGCAGGAA GAATJTGTAGC TGAAGTTTCC CAGTGGGTGA CTGCAAACCA GGCYJ7CCATG CTCAGGGGAT TCCAGGGCTG TACAGTrCAC AACTGAAAAA GAAACCCAAA TCAGT-rCTGC TCATCTCTCA CCT17AACAG ATAAGAACAC TGGAAACTAG AACTACAGTT TGGTTTTT TTITTAGT TTAAAAATTT ATAAAATTTC TAATGGAATT TGTAAAATTG ACTGTAATTC TACCCCT-17T C3TMATTCA AGAAAATGCT GATCCATAAC AACAACAACA AAAAAGCAGT GATGACAACC ATAAAAAAGA AATATTGAGT GATATGGGGA GAGTAGTGTA ATTGTGTTTA CCTCAAAACT GTTCAAATTA CTTGTTrACTT TTCTCACAAC TGCTAAAAAT AGCTATATTT CAAATU-AAG TACTAGAATA TAGTAGCCAC TATCTGTGTG GCTACTCAAA TCAGTTCCTC AGTGTCACCA GCCACATTTC GAAAACACAG CTATGGAACA TTTCCA'FrAT GGAGAGAAGC TCATCTAACT CTCTTAATGT TGCTCCATGC TACACGGCTA GTCATrACAG GTAACTCACT CATTTCTACT GCAACGTCTT ACACAGAATT ACAGYI'TATT GAATGTGTCC ACACTATTAT TATCCTCArr TTACAATGAG AAAATAAATA ACTGGTGAAT CTAGGACTCA ACCATATGAC ACCATCTGCA CCAGGGAAGG AGATGGTGCT ACCATCTCAA GTGAAGAAAG TGAAGCCAGG GTCACACTTG CAAGTGTAAI TGTATTGGTA CAGGCAGCTA CGGAAAATAC TATGAACAAA CACAGCAAAC TrAGGTACCA ACTACAGTAA GCTTCCAACC AGGATGAGAA CATTACAAAT TTJ7AAAACCC TAATGCTGCA TTTAAACTTG AATTCGTrGA AATCAAATAA AAGTACTCAA TAACCACATG TGGCTCATAG CACAAAAGCT CTACTGCACA ACGCTGTGCT ACAAATTTAG GAACTGAGAC CTCATTTCAT AGCCAGAGGC CAGAGCATGA ACCAAGATAC GTI7ACCACCT AGATGAGGTG AGTACATGTT TGTGTGCCAG GCACCATGTA ACCATGAGCC AAAACTGACA TAGAGAGTTA AACTATCTTG AACCCAGCAG GGTCTGACTT CATAGTCTCA GAAGGCATGC AGACCTGACT CTAATGCCAG AGGCAAGAAC CAGACTTACT TrGCTCACAC TAYITGATGGT CTCTACACAT TCACCGTGGC AAAGCATGAT GAGGAGGACT ATTACTGTGC

CAACAAATTT

CCATTCACAA

CTGTCTACTA

CATTI7AAAAT

GTACACACTG

AAGGAATCT[

TCAAGTGACT

CCTGGACTCT

CCTCGCAGGG

TATGAAGTTC

TCAAGGTGCC

GCTCACGATC

CTAGGACGTG

TTGAGTCCAC

CACTGCAGGA

TTATACTGAG

TGCCTI7TGAT

ACTGAAGTGT

TAGCTGTGGC

AATAAACAAG

CAGTAYITTAT

TAAAATGTAT

GTGTGTGTGT

C'FrAGCAGT

AAYITTGCCAA

AGGGCAAGCT

TCTCCACGCA

CAGAGGTTTC

GGTGAATAGC

TTTAGAATCA ACAGTGTGCA TTITACAAAGT TCCAAATCTG TGGCACCTAC CGTAGAAAAT TAAT7AAAAT ATGTATTGTG ATATATITITA TATATATACA ATAAATGCTG TAGOCTATAT ATATATATAC ATATCCACAT TAAACAGAAT CTTTTGGAAC GATGCCCACA CACTGAAACT TCTTCTTGCT GCACCTCTCA GTCCTCATCT TITTGCCTAT TGGGTTrCCTA CCCAGACCCA TCAATATGGA GTTAGGTAC ACAGAGACAT CAGCAGTCCT ACAGAGTGCC ATAGACYITA AGTFITCAGGC CCACCTATCC TAAACCTTGA TGCTAATGTA TTAC'FrCTTC ACAAACTCTG AAGACAGTTC CCCTACCACA TGTGTGCATr T7TATATGTA AAGAACTACA TATTTGCCTA TACACACATA TATGTGTGTA TATGTGTGTA TGTATATATA ATATATACAC ACACACATAT ATGTGTGTGT GTATATATGT ATTCTTGCCC ACATICACAC AAAACAGCAA AAGAGAGAAA ATAAAATGAC CACAATAGAG AGCAGTTT- GCATGCTGTA ACCTCCCACT GCTGCCGCAA ACTCCCTACC TGTGTAGCAT TCATTCCACA TGCCCACATC 'T=~CTCTC TTGATGTAGA TGT-rGGGTTC ACCTGGAGCC CAGTTCT-rGG CTITCTTCTGT CACATITGTTG ACTYFTCTGA TrCCAATCCA GTAATAACTr TCAATCTCTT CTTT G AATTGCAACC AGGTGTGTGT ACCYITGCTG ACAATAAGCA CTGGCCTCAT CATAAGTCAT AGCTTCCGTG GAGGTGTTGT AAGACCAGGC TCCACTCTCT TTAATGAGAA GCACTAGTGG GAGAAAAAGA AAAGAAATGG TAGAGTTTGG TACTGTTGTG GTTTAACTCT GACAACTGTG CT=TTG TCTrATrTT-r GGCAATGTTT GTGACATGGC CCAGACTT CTCATCTTr CAAAAGTAAG AAGTACGTAT GAAGAAACAG CGACTrATTG TTITATCTCTT YI7GTGACTGC CACCCACTAG GTACCTTATC CACACTCACT CACAACATTA TAGTATACCC ATJTTGTAGT AGAATAATAA TCAGAATAAC TAAGCTTTAT TGAGCACTTA GTATGCACCA AGAAGCACTG TATGAGGTAC TTrCCATGAA CCATGCTATT GAATCCTCAC AATGCATCTG GGAAATAGGT CATTATGATC CACACTI1TAC ACTTAAGGAA AGGGAGACAC CAAGAGGTAA AGTAAATGAC CCCAAGCCCA GGGAAGAACA CA11TGCAGGT AGAGGTCAAG 204

GATGCTGCCA

TGCGAGAATG

CAATCATGAC

ACAAAATGAA

TCCTAAGAT-f

AATTTTAAGA

TACAGATGTG

GCGTTCTGCA

CCTCTGTCTC

GAGjGCccTYT

AAATCCCCAA

ACTCTGTCTC

CAAAAATGCA

T7AGTAGTGT

UTGTCATCCA

TCTTCCTMT

AGATATTAAT

CACTCAAATG

AAGTTTCATG

ACCACTTTGG

AGAAACGCCA

GATATCCTGT GCAGGACAGC CCCAGACAAG CAAGGATATT TCAGTCTGAA ATATCTATAG AGAAATCTTG GTCTAATGGC ACTGACTTAC CCAAAGTGAG AGCTGAGAGA AACTGTGAAG TTCAAGAGTT CTTTCACCC AAAGGTTTAG GCTTGAAATA CTTTCCTGGG GAGATAAAAC TfAAAGAAGG AAATCGTGGG TAGCTAGTTA CAUTATTCTA CCATGATGTT TAAGGCAGCA TTGGGCAAAG GACACTAGTG CAATAATCTI' TATTTCAGAG YFTAATCAAA TAAATAAACA CTFrTCATTAT 'ITAGGTCAAA GAGAAAAGAC AGGTTTTAGC TACAATACAA TAAGAGCYITG GTTT-rTATTA GAAGGCCTfT TGCATATCTG TG1TICATGG CCCGAGGCTG CCCTfATAAA CTTACCGTTr TGGGAAGCAG TrTTCAAAC ACAGGATCTC TCAGGTGGGT ATCACTGGTG AGGTCAGTAT AGGAGTTTTG ATGTGAAGTC AGCCAAGAAC AGCTGAACAC TACTfCGGCT TATAGGAGGG ATTGCTTCCT GTGAATAATA GGAGGATATT GTCCACATCC AGTAAAGAGG TGGCATCCAA AAACTrTCCC GGGAATATCC ACGATGCYFA AAAUTACAAT GATGTCAGAA TGAAGCTAC TTCACCTU7G TCCATGCCTI7 TATATCGTAT ATGCAATTFT ATTAATATGA TGATT1TTTAA TTATAATAAC ATAAAGTCTA TGTCTTTAAA AAGTTGTAAA ACTTTGCTTG CTCTCATGTA GTTGTGGTAG TAATTAGAAT TTCAGAAACA GAAGGAAACC AAGAATAGGT TAGTCTACTA CCTTCAATTT CTCATTCATA GCTGTGGATA ACCAATCACT ACTCATrTTTT TCACCTGCCA ATTCAACATA TTTAACATGC ACTGTCTCAC AGAGGAATGA CTCACAAGGT CY[CAGATTf TGCACGGCAG TTATGCCTAA ATTAAAATAT TATCTAAAAA TAATATCTAA GTTAAAATAA TGCCTTATTT TAAAAAAAGA AAAATGGGAA ATAGATATTT ACATCTGGGA GT-rTGTTCAG TGAAAAAAAT AAAAAGGAGG CCAGGCACAG TGGCTCACGC CTGTAATCCC GAGGCCGAGG CAGGCGGATC ACCTGAGGCC GGGAGTTCAA GACCAGCCTG ACCAACATGG TCTCTACTAA AAATACAAAA TTAGCTGGGC ATGGTGGCGC ATGCCTGTAA TCCCAGCTAC TCGGGAGGCT GAGOCAGGAG AATCGCTTGA ACCCGGGAAG TGGAGGTI'GC AGTGAGCCAA GATCACGCCA GTGCACTCCA GCCTGGGAAA CGAGTGAAAC TCTGTCTTAA AAAAAAAAAA AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT ATATATATAT ATTTAATTGG TCAAAATTTT GTTTAAAATT TTTGAAATGT TAATGTGCAA AGAATAAAAA 'FrCTTCCACA ATGTTAACAG TGACTAACTC TGGATGGCAG GATrGGGAT AATTITTTATA TCCTTCATTA TTATTTTCAG GATITTAAAG T1TTTFCAA TTTCCCTTTT TITTCACCTI7T ATAGTAACAA GAATACAGTT TAAAGAAACT TGTCTCTAGG CCAGGCATGA TGGCTCATGC CTGTAATCCC AGCACTTTGG GAGGCTGAGG TGGGTGGATC ACCTGAGGTC AGGAGTTCCA GACCAGCGTG GCCAATATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ATTAGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGGAGC CTGATGCAAG AGAATCGCTT GAACCCAGGA GGCAGAGGTT GCAGTGAGCT GAAATCACAC CATTGCACTC CAGCCTGGGC GACAGAGCAA GACTCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAAAG AAAAGAAATT TGTTTCCAAA TGCAACAGAA GGAGATGTAT GTGGTATCCT ATATTCCTGC TCTTCATT-T GACATrTTCTT CTGGGTGA'17 GTATACATTC CCCATCTCTG CATCTTACCC TATCTAAATG ATGGTAACAG TAAATGGGGA TCATTTTAAT TTCCATATJTC TGTAGGTTf CAGAGCTCAA GTCAAGCTAA TATTCTATAT CTACAGCCT7

AGCCTCGTTT

AAAACAAGAA

TCAAAATAGG AGGTCTATCT AAAAATGTAC TGTCAGCAGA CCTGAACGAG TTCTCTTTAC TTGTTAGCAC TGGTCTTTCT GTGTTCATAA AGATGTCAAG AAGAGAAGAA AAATTCCAAA AAAGACAACT GATTAGAAAA AAATAACTTA

TAGTGGTAAA

ACCCAAAAAA

ATTAACGAAT

YFrAATTCAAC CCCTATCAAA AAGCATAGAA TTTA'ITCCCT CCACCTFACC ACTCTCTTAC ATGATCCAGA TACTGACA11T ATTCCAATfTC TUTATCCCAC TTTACTTAGC TCAATGTGGT TGTTGCTTCA ATAAATTCAG AAGAGTAATC ACTCATATAG TGTTTATTTA GATTTTAGGG CAGAATGTCA AGTTGGGTTA ATACATTATC TGTATGTATT TTATTT1TAA TAAAGTATGA ATACATAATC TGCTAT17TT AAAAAGCATG GTCAAATGTA TAGAGTAGCC AAATCTTAAA AAACAATTTA TCYJ7CGATAT CAATAAAGTA CCTAATAATT ATATTGCTAA TAGAAATTAG TCGTTAACAT CCCTAGATAA CTAACTTTAT TATTGCGAAT TTTTCATAAC TAAGTTTATA GTTTATCTCT TCCCCTTT AAAATTAGTT CAAAGATATC TAAAAATAGC CCCAGTGGTG ATGAAGTTTC TAITFTACYI7 ACATATATAT GTCCTGGACC CCCAATTATA ATCTCTAACA TITTATI7GAGT GCTI7ACTATG TGCCAGGCCA TATTCTGAGC ATTTTGTATG TTCACCTATT GA'FrATTCAA TCCGTACAAC AGCCTATGAA ATAGGTACTC CTATTATCCC CAYITTTACAG ATGAGGAAAT TGAGAATCTG GGGATTUFTAT CTCATTCAAA AGCACAGAGC TAAGGGTTGA AACCAGGCAG TTGATATCCA GAGCCCACTC CCTrACCTGC TACTCCAAAC CATGATTTCT TTTGTTGTTA TGCCCCGAGA T-rCCTTGT-rC TACCCAAGTT TCCTGTACTC TTCTTGCCCT cTTrCTTCCTG AGACATCCTT GACCATCACA GCTCTCCACT GAGATAACTG TGTCCTGGGT TCTGAGACAT GGGGGCTGGA AGGGACCCCA GGGACAGTGA GCAGTAGGGA GAGGATGCAG TGAGAACAGA CCCTGGATCC CCGGTGCATA GGCAGGGAGA AAGTGGACAA AGGAAAAAAC AAGCAAGGCA GGTGGAGCCA TGCCTAGGTA AAGTTGATCC CTAAGCCACA G'rfCCCAGAA GT[CCTGATT CAAAAGCAAA TTfITCTCTAA GGTCAAAGGG CAAACTGATT ATTCTAAATT CTAAACTGAT TATTTCTAAA TTGAGAAAGC TfTCAGGGAGA GATCCCAATA TTCGAAGGAT AAGAGAAATG AGGAGTGGAA GAGATAGGTG AGTAACAGTA ACYUrAAATGT AGACTATATA TAATATATAA TATATGTAGA GTATATATAT ATAATTACAA TATATTATAT ATGTGGAATA TATATATTAT TrATATATAT TTATATAT TATATATATA GATATTTTTA TATTTTATAT ATAAATATAG ATATTTTTAT KITrATATA TAAATATAGA TATTTTTATA TATATTATAT ATAAATATAT GTAAAATACT GTGAAAGAAG AATAGAATCT TGAGACCTCA AATTCACTAT GCCAAAGGGA AAGTTAAGCT TGGGAAATGA GTCATGCAAA AACTGCCTTC CYTTGTTCC CAAATACCTG TAATTTCACA TGCT-rACT ATCTTATATA AAATGTAGAT GTACTGAGCA TGAGATCCAT GCATAATTUC CCTCTAGTCC CTrCTTTIA CATGTAAAGT GTAGACTCAC

TGAGTGTITAC

TCCCCTCCTG

CACAGATCCT

rrCAGTTACT

GTTTTAACCA

TCTGTGTCCC

TCTGGCTACC

AGCGCTGCGT

AGAGCCTTGC CACAATGTAA ACACTTGTCT CATTGCCAAC CCATCTTTCG TfrAITTCT CTTGCTCT-fT CCCCTCTAAA GATGGAAGTT CCCAAAACTC TCTTTGGAAA AAGCGCAGGT ACAGTGATTT GTG1TTT TACCTGGGAC AAAATAAACC TCTAATCTGT TGAGATATGC TTGGTTTA CAATATGTAC ATGTATGTAT ATAAT17ATA TGTATATAAT ATATGTACTT GAGGTATGTT ATTCAAAATC CATTCATCCT TACAATTACC TGCATTCTCC CACAGTATTT TGCCCCCGAG GTrGTCACTG CAAATCAGGT ACATGGATAC TGGGAGCTGA TGGGCTCCCC TGGGCTGCTG AAGGGGCCAT AGACAGACCC AGCTTT7CCTC TCGTGGAGAG GCCCTGGGCC GGGAGTGGGA TrACAACCAG ACTATAGCTT CYI7CACCTGC 'T=rCCTAT CAGGA'rrTCA TAAGAGGCAA TTGcTTGTTT TTGAGGGTG GGGGCAAATG AGGGGGAGTF GAAGAGGAAA TTGGGTAAGA TTrTGAATAGT TGGGCATGTT GAATATTATG AATATCATCT CCCTC1TCAA ATAATCCAAA ATATACCCCC AAGAAACAGG CTGATTAGAG GTGC11TCAAG GCTCCACTGA ATCTCCCAAG CTCTGAAGAT GTAGCTAGCT GTrACCGGAT TGCCGGTITT CAAGCCTCGC CTCACATGGA CCCTCTFGGC AGTrTCTCGC ATGGGGOAAG CATCCGCTAC ATAGATGGGA ATGAAAAGAG GAAAGAAGAC GGTGCAAACT CAGGCACACC CCGGTGTCTG 205 CCACCAGTGC TATTTAATCT CTGAGGTGTC ACCCTTCCTG GCTTrTATTGT CTCUTCCTGG TCCTCTCCTC CACACCCYTr AATCAGGCAT CAAAGACT[ AACCAGTTT GCTGTGTGCC CATTCTCACT TTTATGGCAA AGGGAGTGGG AGACAGAGAG ATAGCCAGAA AGAAGAGATT AGACAAATGT TAGAATTTTA ACCAAGGCCA CCCTGTGGAC AGGAGATTAT TGGGTrTAGT ACTGGCCACA ACCACACGTG GCAAAAGCAT CTATCGAGGA GTGAAGTTAT ATTI'GGTGAA

AAGTCTCTTG

CAGGCCCACT

GGGGACCCCA

GGAAAGCAGC

TGTGACCGGG

AAGCAGGGGC AGTGGTGTCC TCCTGCC17C CTGAGGCACT CTGTTCCCTT ACCTCTGCGA AGGCTTATTT TACCCCTGAG TGCT-rAGTTT TGAAAGCCTr AGTTCCCTCT CTCCCATAAA AAAGCTCTAC TCTGCTAACA TCTAAGTTAC C1TrGCAGAG TCTTAGGTAG AGGGAGGAAA TCCCAATAAA GATfCCACCC TATCTGCAAA ATACAAACAT GGTAT~rCTT GCATTCCCAA AATTGTGAAA GAAAATGTGT ATCACCACAG TAGAGAATGG CATTTTTTGT TTGATCAAAA CCTAAATATA TT[GATGAAA ATGTGTCTGG TTCTAAGTTrT ATTTCCCAGA AAGCCATGTT TACTCACTTG GAATT1TATAG ACATCTTATA ATATCTGAGT CGAGTAGGAG CTCCGGGCTC TACCTCACTC TTTTCTCCCA CACCCAGGGG GAAGTGTAGG GTTCTCAGAC TTrAGAATAA AGAGGAATCA CCTGGACAAC TCACCTAAAA TGCACATCTT CAGGTCTCAT ACTCAGAGGC TCTGACTCAA CAGGTCTGGG TGGCGCCCAA GAATTTGGGC T-rTAAATGAG TATCTCAGAT GAT-rCTAATA CAGAATGTGT AAGATGACCA GATCCTATCA CACTTrAGATG TATTGGCCTA GGGCCACCTA ACTFTGGAGAA AATGTrAGTA AGACCCCGTG GTTGGTGCTC AGCTATAGGT ACCAGAAT1T TGATCAAAAT TTACTATCAT TGTGACACTT CTCTTCGGAA CTGGAAGGCC AGAACCCCAC TTrGTAAAGTG CTGGGAAAAT ACAAGGAAAA TTTAGGGTGA GTAGCATT GAATTCTTAC ACATGGAAAG TAAATGTATA AGAATTCTTA CCAATAAAAA AAAAGCAAGA GAGAATAGCT GCTAAAGAAT TAACACAAAT ATGTATATAT TAGTTATTCT C1TFCTCCT CTGATTCCAG AGGACMI~GT AATTCCACTA A117cTTCTTG AGCTTCCAGG ATGATCTGAG ACTTGAATTT T-rCATGTGCT TTTTGCTTCC TAI-FTGGCAG CATCTTATCT TGAAGTTTCC GCTTTCTGCT TGGGGACCTA AAAACTAACT AATGGGAATT TCTTCAAAAT GAGCAAACTC TGGTGAATTC CCAAAGCGGA AGAAACAAGT GAGGATCGGG CTGGTTAATT AAGAGAACTT TTCCTGAATG TAGCCAGACT GTTTGCCGAC TGTTGTI'AAC ATGAGGGAAG AAATACCCCT GGATTTTAGA AGAGCCCCTTr GTTTGTTC CTrGGCCATT TGTGCTGCTT GTTTTGTAAG TCAGAAATTT CCTGAAGGAC TATTATTAGC TT-rGT-rCTCA CGTCAGAAAA CTTCTGCTCT GGCCACTTTT AAACATATAA CTrGGATTTT ACTGTATTAG AAAATGTAAC AATTACAGAC AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC TTf'F7TT-FCT TCCCCAAATC TAAAATAGGT GATTTTGGAG AAGTAGGAGA AAAACCTGGA TTTTCTAGAT CTCTTTAGAG CTCAACAACT GATATAGTFA ATTATGTAAG TCYJTTGATAT TTGGAAATGA TTGGATTAAC CGGATAACAA TGAATATTTA AATACAGTGA TTTGGCCAGG AGCAGTGGCT CATGCCTGTA ATCCCAGCAT TTGGGGAGGC TGAGGCGGGT GGATCACCTA AGGCCGGGAG TTCCAGACCA GCCTGGCCAA CATGGTGAAA CCCCATCTCT ACTAAAAATA CAAAATTAGC CAGGCGTGGT GGTGCAAGAC TGTAATCCCA GCAACTCGGG AGGCTGAGGC AGGAGAATTG CTTGAACCCG GGAGGCAGAG GTTGCAGTGA GCCAAGATCA CGCCATTGCA CTCCAGCCTG GGCAACAAGA GCGAAATTCC ATCTCAATAA ATAAATAAAT AAATACAGTG ATTTAACACA AGAGATT-rCT AT-17CACACT AATGAGCTCT GTCACTGGGG CAAGCTTCTT TGCCTCATTA AGTCTCAGAT TTCCCGAGAG CTTAT7TATT TATACCAAGA GTGC1TACT ACCGTCTCTG CTAGCTGTGA CATAATATGA CAAAAGGTAT AAATATGGGA AAAGGCACTA ATTTATATCA AAGCGTTCTT CGTTTTTCCT TGCTGTGAAG TT1TTTAGCTA ATAATTCATA AGAATATACC ATATTTAGAG TGTTTACTAT GCATGGGCCT GGCACTTCAC ATACATTGCT TCTTACAAAT TTTACAAAGT GAAAGGTAGA TATI7AATCTC A17TTATGGA GGACAAGATA GAGATCTGGA GAGGTTACAT AACTTGCCAG TGTTf-TCA GTTAATAAAT GGTAGGGTGG AGATTCAATC TGTGTTACTC TAAAGTCCGT GTCCTIT'TA Yr7GGCTCCAT GCCTACTCAG ATTUAAATCT CAGCAGGGAA GTAAACCT~rA GTTTTTACAT GAGAAAATGT TACAGCAGCC TTCTCGGCTT CCTFTTACCCC CATCCCAGTT TCACGAGCTr AGTGCCTTAG ATCGGGTTCC TTrTAGAAGCA GACCTCGAAA TAAGGATGTG GGTGCCAGTC ATTTATTGAA AAGATGATCC CAAGAAAGCC TAGTAGGAGA GTGAGGAAGT GAGATGGGGA AAGGAAGAAA CTCCACAAGA AGTGTGTTAA TAAGCAGGTT ACCGCTGTGG GCAGCCATGG GGCTCAGCTG CACTAACAAA CTCTGTCTAG TACAGAAAAC CTCAGGGTCT CCCCAAGGAG GGGCAAGAAG TCTGCCTAGG

GTATATATCC

TfCAAGTGGA

ATGATCTGAA

CAAACCTGAT

CTCAACTAGT

GGAGGCTTGG

AGGACCAAGG

ACTCTCTGAC

TCTCCAACTG

TGGGATTACA

ATTCCATCTA

CAAGACTGGG

GCCAACTCAG TCACTGGCTG TTCCTGTGGT CAGAAAAAGC TGCTGTGTTG GGACAGGGTG GGCTGCAAAC AACACATATT TTCTCTGCTC TAGGTTTCAC

AGAGCTGATC

CCTCTACAAT

GGCGTTATrA

TATTATGTCA

ATTGCCAATA

GGATGAATCC

TCCCTGTTGC

TCGTGTCTCC

TGCCTTrCACC TTGGATT7AT

CAAAGTCCCT

CAATTCACAA

ACTI1TCAAGC TCATTCAGAT CT'TGCTGGCT GTT7GGCCAGG ACTTCACCTT TCAAACCAGC TCATrTCTCC TCTGTGTACC TCAATCCAGG ATAATCTCCA TCCAATAGTA CTGTATTAGT AAGAAAGAGG TTTAATTAGA

CTGGGAGGGC

GAATTCCAGA

GTTTTCTGTC

TAGTTT7GTGT

TCAAGGTGTC

TGT7GGCAGA

AGTCATTCTT

AGCGGCTAGT

ATGTCTGCCT

TATITAAGG

CCAFITCAT

TTrACAGTTC

ATGGTTAAT'T

TGCUrGTATT

ATTACTGTAA

GGGTCAGAAG

ATCCAGTTGG

ATCCAGTTCC

AGCTTCTAGA

CGAGTCCCTC

CTACTGCTTG

CTAGCTGACT

GCTACTGATA

CACATGGCTG

ACAATCATGG CAGAAGTCAA GGAAGAGCAA GTCATGTCTT CT'TGTGCAGG GAACTCCTCT TTTTAAAACC ATCAGATCTC ATGGGAAAGT CTTIGCCCCCA TGATrCAATT ACTCCCACCA ATGAGATTTG TGTGGGGACA CAGCCAAACC ATATCAAGTA GAGCAGAAAT CTTCAGGAGT GGGGGGCATC TTTAGAATTC ACATAGATGG CAGCAGGCAA ATAATACTTA TTCACTATCA GGTCCCTCCC ACAACATGCA CCTAGATTCA TGTI1'GATTA TGCCCACCAA GGCTGGGCGC TCATGAGGTC AAGAGATCGA

CCTCTGCACT

TAAATCTGAC

CAGATTACTA

TACAGGTTAG

GCTCTTCTTG

TfGTGGTTGC

GACTACCTGT

TCT-rCAAATG

TAAGGGCTCA

AGTGATCTTA

AAGACATACC

GGGAAGCCTC

AGAGAGAGAG

CAAGAACAGC

GGAATrCAAG

AACAACCAGG

GGTGGCTCAC

GACCACCCTG

ACCTGTAGTC

TGAGCCAAGA

TGCCCATCAT

ACTGTGATGT

AGGGTT-rGTC

ATGTCCCCTT

ACTCTGTGAA

TTAATCTAGC

TCA'ITTGATC

GTTAGAGTTT

CCATCTGACT

ACCTGTAATC

GCCATGGTGA

CCAGCTACTC

TTGCGCCGCT

AGTAGGCTGT

GTMrCTGAC

TAGAGTTITA

GGCATTTATC

CTGATGTCCC

AGTTATCATT

ATCATAATAT

AAATAACTTG

CCAGCACTr GGGAGGCCAA GGTGGGTGGA AACCCCAYT CTACTAAAAA TACAAAAATT AGCCAGGTAT GGTGGTGGGC AGGAGGCTGA GGTAGGAGAA TCACTTGAAC CCAGGAAGCG GAGGTTGCAG GCACTCCAGC CTGGGAGACA GAGCAAGACT GTCTCAAAAA AAAAGAATTC CCTACAGAGA CATAACCCAG GAATTAGGTG AATGGCTAAC CTAAATTAGC 11TGGTCCTTA TAGCTCCTCT GCTTAGATGT GGAACTAATC CATGAATGCA AGTGGGAGTT AAATATCCAA AGTACAGGAG ATAT-rATGGG TGCCTCATCC TTC~rGGAT AACCCAACTC TATTAGTMr TATATCTCAC 1TGTTCCTAT ATAAATAGAC ATITGCATTTT GCCAGTCTUC TTGAACAATA ATTACGATTA AATTGGCCAC 'FrCACATrAG ACACAGCACT TAGGACTTAA GAATACCATG GGTCAGGAAT TAAGTAUTGC TATCCAAATr YFACAAAGAA GGCACTGAGG CTTAAGATGT CATAGCCTGT AAGTGACAAA ACTAGGACTC AAATACAGGT 206 CCAAAGTCTA TGTTCTTGGC TACCACACTG CCTGTCCTAC AAGTGACCTG TGGTTTTACT CACTCTACTA ACTT[ACCAT CTCCCATGAG TCTGTCTAGA GGAGGGCACA CACAGGACAG AATGCAAAAT AAGGAAGGGC CTACTTACTA CACAGAGCCA TTCTAATACC TGATGTTTGC TTTTACTATT AATrAGTTGC TGGTGCCCAA GTTTTTACTG AGAAATGGGG ATAATIT[GG GATGCCUrCT TCTCATAGGG TATTTTATFT GT-G'FfGTAT CTCCAGGCCC CAACACAGCC TAAATGATCA AAAATACCTG TI'GAATGAAT AAATGGAGTC ACCTGAAACA TGTTAAACAT GTCCTAATCG TGGAYTTCAG GATAGTAAGC ATCCTAAAAG GAAAGCATGC ACACTGTTCT ATTTCTCACA ATATAAAAAA AGAAAAGCAT CTGAAAAAAG CTGCCAGCCG CTGTGTCTCC CTGAGCACAG ATATGGAGAA GCTAAGGGAG AGGGATGATG GGCCATGCCT CTAACCTCAT GTCCTGGGGG TCAGACCCGA GGAGAGCAGG AAGTGTCTTT TGAGGGATAC ATT-rcCACAG GAGACTTAAA TAAATATTAT ATACACAGTT CAACTGTTTT TATGTGTAAA GGTAGTAGGT AGGAAGCACT TCTTTT[ TGTTTGAG ACAGAGTCTC GCTCTGTCTC CCAGCCTGGA GCTATCTCGG CTCACTGCAA TCTCTGCCTC CTGGATTCAA GTGATTCTCC TGCCTCAGCC CTGGGACAAC AGGTGTGTGC CATTACACCT GGCTAATTTT TGTATTTTTA GCAGAGATGC TGT-fGGCCAG GCTGATCTCG AACTCCTGAC CTCAGGTGT-T CTGCCCGCCT CTGCCTCCCA ATTACAGGCA TGAGCCACTG CACTCACCAA GCACTTCTAC TGATAGCATT TACAAACCCT

ACTATATTCA

AAAACACATG

TCTAATCCAG

AAGTCATAAT

TGGCTTTTrAG

TTGTTCATGT

TGCTACATTA

TAATATCAAA

CATGGCAAAA

TGGAAATAAT

TTTCACAGTA

GTACAGTGGT

TCCCGAGTAG

GGTTTCACCA

ATGTGCTGGG

TCTTAGAATA

CCTUCATACC

UTTAAAAATT CTAAGAGAAG AGTAAATTGA GCCTfCCCAA CTAATACTAG GAGGTTATAA AAAACTGGAC AATGCTTGCA CAAAAGAAGG AAGCCAATGA GGCCACCTAG AAGGAAGACT GGGCATTGGG CCCAGTGAGT CCTGGAAACC TCATCTGTGC CAGCCACCCC GGCATGGCCT GTATGAGTGG ATGAGGGTGA cTITGTCCACA GACAATAGCC ATCTAGCTGT GATAAAGGAG TCAAGGTAGT CAGCTGCATC TCTTTCACCT GTTTGCCAAT GTrACACAGG 1UGAAAAGCT AAGGTTTATG TAAAGCAAGC ATCAAAGATG ATGAAATGAT CAACCTGACA ATGAGTACTA TGCTGCATTG TCCAGAAAGG AACTGTGGAA GATTTrGGGC TGAAT'TTCAA AACAGAATTr CCTCACTCTC TGGATGTTGG CTTFACTrGGC CTTTGATGTT CAGAGGTGGT GCC1TTTGTGT TGTrGAACAA TGTrGATT GGAGAGAAAA CAGAGTJTGAA AAACCCACAA GTCATTCCCT GGGGAGTATT ACCGGAATAC AGAGGATAAT T-rCAGCAAGC CAGCAAGGCC TCATCTCTGC 11TCTAATAGA TAGGAAGAAA GGAAGAGAGG AACAATACTT M~TAAGAAG CTCAGCTTTA TCGCCT-rATC TCATAGAAAG ATGCCTCCAG TCTGTCTGGC TAAAGGTAAT TGGCATGGGA AAGTCTTTAT CTGTGATTCT AACAAGTGGA ATGT-rTCCCT TCATTAAGAG AGCCTTGTCT GGCTTGGGGA AATGAAACAC TTTCTCCGAT ATGAGTGGGC TGTAACCCCT GCTACTAAAT ACTCAGAAGA AATAAGGCGG TTGTGGAGCA GTCAGGAATG AGTCACTTGC CTCCCTGGAA TATTCAGAAA ACTGAATCAA AAGTACATTC TTCTGGGTTT TCTTAGTCTA ATAGACTAAG GGTCTCTACT YTGTTAAATT TCTGGGAAAC AGCATAGAAT GGGAGAAAAA ACTGGTCACT GTAGTCATGC AAATCTGCAA AACAAACAAA AAAGTCTGGG TATTGCTGCT AACTAGCTAT GTGACCTTAA GCAAGGTATr AACTCTCTCT GAATTTCAGG TTCTTCATCT GTTAAATAGC ATATCTGTAA AATGGGAATT ATTTTCATAT CATAATGCTG TAGCTTTAAA AAATAAAATA AAATGGATGA GATAATCAGA ATFTAAAGAGC CTGGGATATA TAGTTAATAT ATAGCAGCAT GTAAAGATCC TGTTAGAAAT GCTAATrTTA CAGTTAACCA TTTGGAGATG ATCCGCCAAA GCTGCTAGTG TAGAGGCAAC TGAGAATTTG CCTGTCCTTC AGAATATGAA TAAATAACTG TCAATGATGT CTCAAGCCTA GAAAAACCTA TCCATCTGGA TGGGTGGGAA ATTTCTAGGC TAGTATf GAG AAGCCCATTT CTTJGGGAAAT AGGTCCTGGA CTGAGTGAAG GAAAAGAAAC AGTAAAACCC ATGGTAAAGC AGCAAGGCTC TCTAGAGGCT CTGGAGAGGA TGAATTGAAT TCTAGAAGAT GAAGTAGGGA AGACGCTT[A CCTTCTTGTG AAATGGATTC AAAGATTCAA AGACCTTCGG GAATCTCCAA TTGTATAAAT GGCACCATAG CTGTATGTTC CATGGAACAC TACYJ7CCCAG AGATGCCCAG TGAAAAAAGA ATGCCACAGT CAAATAAGTT TGGAAACACT CCATTATGTG GCCACCTCCT TGAAGACTCT AATGCACATT AGCATGTTAA ACAGTCTTGA GAAGTCCTGC AGAGCAGAAA TTGCTTCACA TCTGCTAAGC CGGCAGT17C CCAATATACT TGATTATGGA TAGTTTTTC CTTACAACAC CATTCTCTGA TATGCTTCCA ATGACATGAA ATAAATATAT ATGCATGAGG UTCTTCA'rrA GGGCATAC1T TTTAATAGAA AATATTGAGA ATAATCTAAA TATAAATGCA CAGCATTTAC CTT1TCTGCA TAAACTATAT ACAGGCATAC CTrGGAGATA CTATGGGTTr GGYJ7CCCACA ATATCTCCAA AACCACATTC GGTTTTATGA CCACTGCCAT AAAACCAGCC ACATGAATTr 1TTGGTTTCC CAATGTATAT CAAAGTTACA YUTTTACTAT ACCATAGTCT ATTATATATA CAATAGCATrF ATATCTAAAA AACAACGTAA ACACCTTAAT TTAAGGCTGT GGCTGGTTTG ATITCTACC CAGACCACTA AAACTTTCTT CATATCAGCA ATAAGGCTGT TTrCACTTTCT TACTATrTTT TGTGATAGCA cTT T-TT CCT7CAAGAA T-rTl7CCTTT CTATECACAA T-rTGTTTGAT ACAAGAGGAC TAGATTTTAG CTTATCTCAG TTTAAGGTGT TTACATTGTT AGCTAAAAAT GCTAATGATC ATCTGAGACT TCAGCAAGTC ATAATCTTTT GCTGGTGGAA GGTCTTGCCT CAGTGTI7GAT GTCTGCTGAC TGGGTGGCTT TGGCAAT-rTC 1TAAAGTAAG ACAACAATCA AGTTfGACAT ATCAATTGAC CCT-fCCTGTC ATAAATGATT TTTTTTTFCT CTGTAGCCTG CAATGCTCTT TGATAGCATT TTACCCACAG TAGAATTFITC AAAATTGGAG TCAATCCTTT CAAACTCTGG TGCTGTTTTA TCAACTAAGT TTATGGAGTA TrTAGAAATCC CT-rGTTGTCA TT-rCAACAAT GTTCACACCA TCTTCCCCAG GAGTATATTC TACCTCAAGA AACCACTTTC TTITGCTCATC TATAAGAAGC AGCTCCTCAT CCACTAAAGT TITATCCTGA GATTGCAACA ATITCAGTTAC ATCTTCAGGC TCTACTTCTA ATTCTAGTTC TCTTGCTGTT TCTATCTCAT TTGTGCTTrAC TrCTCCGCT GAAGTCTTGA ACCCCTITAAA GTCACTCATG AGGGTTGGAA TCAACTTCTT ACAAACTCCT GTTGATGTTG ATAT1TGAC CTGCTCCCAT GATTCATGGG TA117CTTAAT GGCATCTAGA ATGGTGAACG TI-rCAGAAG GYM~CAGTT GGCTTYfGCCC GGATCCATCA GACGAATCCC TATCTATGGA AGCTATAGAT T-rATAAAATG TATTTCTT TTrGTGGGGG CATAGCGTCT CACCCTGTCA CCCAACCTGG AATGCAGTGG CACAGTCATA ACTCACTGAA GACTCAAACT CCTGGGCTCA AGTGATTCTT CCACCTrGGC CTCCCAAAAC ACTGGATTAC AAGCTTGAGC CACTGTGTCT AGCCCAAAAT GTATATCATA ACTAATGAGG C'rrGAAAGTC AAAGTGACTC CTTGATCCAT GGGCTACAGA ATGGACGCTG GGTfrACCAGA CATGAAAACA ATACTCATCT CCTCATACAT CTCCTTCAGA GCTCCTGGGT GAGCAGGCCC ATTGTCAAAT GAGCAGTAGT ATCTI7GAAAG AAAT-rITITr TCTGAGCAGT AGATCTCCAC AGTGGACTTA AAATAGTCAG TAAACTATGC TGTAAACAGA AGTGCTGTCA TCCAAGCTCT GTTICCAC TGATAGGGCA AAAGCAGAGT AGATTTGGCA GGGCCTTAGG ATTM~GGAA TGGCAAATTG AGCATTGGCT TCAACTT1T iTTrrn-r ACAGAGTCTT GGTCTGTCAC CCAGGCTGGA GTGCAGTGGT GCAATCTCGG CCCACTGCAA CTAGGTTCAC ACCATITCTCC TGCCTCTGCC TCCTGAGTAG CTGGGACTAC AGGCACCCGC GGCTAATTrT TTGTATITTA GTACAGACGG GGTT-rCGCCA TGTTAGCCAG GATGGTCTCG CTCGTGATCC ACCCGCCTCG GCCTCCCAAA GTGCTGGGAT TACAGGCGTG AGCCACAGCG CTTCAACTTA AAGTCGCCAG CTGTG~rAGC CTCTAATAAG AGAGTCTGCC TGTCCTTrCA 207

TAATTCTCTA

TTIGAG

GCTCTGCCTC

CACCATGCCC

ATCTCCTGAC

CCCAGCCTGT

AGCTTTGAAG

CCAGGCATCA

TATGCCCTAA

TTACCACAGT

TCTAACCTCA

TCACAGAATT

ITCTATCCAG

GATAGCACTT

CTAGATTTTA

AAAGTAAGAT

GGACAGGCAG

GCCATTAGAA

AGGCCTGAGT

GTTTATCACC

TCGCAGATCA

CACACAGACA

CACAAATACT

ATAATCAAGA

CACTTACCTT

TCATGTCCAT

TGU-GCTATA

AAAGAAAGAA

CTCTTATCAT

TGACCATGTA

AAGAAA1TTTG

AGAACAGTTG

AATGAAAGAA

AAATGTI'GTA

AACAGCCCCA

TGAAAGAAGA

TTCTCTTCTC

AAATCTGTCG

GTCTACATCA

TAAACTAACC

GAAGAATGTT

AACACTAAAA

TTCCTTTCCT

GCCAATCTCA

GTGTGACCCT

ACTCTCTTAT

GCCATTGTAG

TAGCTATGAA

TTTGGTGTAG

TTACTTCTGC

TCCACTAGCC

GGGCCTTGGA

CTTJ7CTTCAT

TCAAGAATTT

GTTTACACCA

TCC'FrTCATT

TAGGGGCTAA

GGTTAATTAA

AATCTTAGAT AGCATCT-rCT CCCAATAGGA AGCCATTTT CCACCTTCAT CA'rrGATCTT ACCTAGATCC GCTGGATAAC TTCACCTTGC ACTTrTATGT TATGGGGATG GCTCCTFECC TCACATTCTT CTMTACAGC UTCCTCGCCT CTCTCAGAGT TTACAC1TTTG GITTAAGGGA ATGCTGTGGC TGGTTTGATT ATCAGCAATA AGACTGTTTC ACTTTCTTAC TATFTTGT TTCC'TCTA TrCACAATTT GACCGTTTGA TATGAGAGGC TGCCTFT~C ACTAAGCTTC ATCATITTTAG CTTTTATTT TGAACACTTA CATGATGATG CCTGGCTTCA AAGCTTGAAA CACAGCTGGC GACTTTTAAG TTGAAGCCAA TGCTCAATTT TTTGCCTAAT TTTAATATrA TGGTGTCTCA GGGAATAAGG ACAGCCAGTC ATCAGAGCAC ACACAACATT TATCAATTAA AGAGGGAGGG AGATGGGGAA TTGAGGGCAC AGGTCATGAT ACTTCAAAAC AA'ITACAATA CCATAACAGA TATAATGATA ATGAAAAATT TGAAGTATTG CAAAGTGAGC ACATGTCATT GGAAAAGTGG TGCTGATAGJ CAATCTGTAA AAAATTCAAT TATCTACATA GTACCATAAA CCAACAGAAC CCTAGAGAAA ATAGCTCACT CCCTAGCTCC TC'I17TTTGCT GTGTACAGAA TITCAAATCCC TGTCTCAGCA CTAATACTCA AAACTGCAAA TGTTAAGTCT TGTAAGCCCA AGCATTrAG17 CT-TCTCCAAA GAAAATAGTC CACYITGGTAG ATAAAATAAA AAATCATTGA TGAGAATTAC CAAAACGTGA A CTTfACTTCAT GCAGGGTTGC AACAAGGTAT ACCTGTTTAT GAGACATTCT AACCAACATA AAATTGCAAA GTATCAAATG GAGACCACTO TATATACAAG AAACAAACAA AAAGAAAAAA AAGCAAAAAT ATGAGATGTT CTCATTTTCC TTTTTGTACG AAAACATTJ7T UTACAAGAAG AYITCAGTCTC TTrTCCATCT ATCTfATAAT CTTTGGTGCT TrACCTACAT

GACTTAGACA

AAAGTTCAAG

GCTGC'rrr

TGATGTGTTT

TATGAAGGAA

ATTACAAAAA

AAGAAAGTCC

ATAAAGACTA

TCAAGAAAAA

TGAAAAGTTC

AGGTGTTYJTA

AGCCTTCYI'G

YTCCAAGGCA

TGACAAGGCA

TATAAGGACA

AGGGAAAACA

TGGCAATATC

TGAAGATACA

AAATATTUAA

AAGTGCAA'Fr

TTAGTATAAG

*CTTGTTrTGA CA1TGTTTT GCTGAGTGAT GGGTCCCTAA AGCATGATAT TGTGTGAATT TI7TCATGGCT AATGATTTT AGAATATGAA GCATTCAGTG GTTTAAGTTG GTTGTTATAA TCTTAGAACA CACTGA11TCA CAAATAAGCA GCTTCTCTCA AATATAATAA ACTCCTTGTC GGTGCTATGT CTAGAAACTr AAAAATATAT ATATATATAC AAAYJTGTGGA AGCAGGGTGT AACTGTTTAA AAGGGAGGGT ATCC1UGAAA GCTTGACACT CTCAG'IMCA TAGATTGCTG GTACGGATGT AAAATAGTGA TAGCAAAAGT GCTITATGCAT TTATTCTTTG ACCTAGTAAT CCTCAACAAT AAAAATATAT ATACATTAGG TTATTAGTTA AACAACCTAC ATGAACAAAT AGGAGACTTA CTGAATAAAC CACTTATGTT GTTAATTTGT TCCAAAAATC CAGAGCCAAA AAAGGGGAAA TAAGATATGT GTGCATCTGT TTATTTFTGT TGACTCTTTT GACGAGGCTG

CATCCCTATA

CCCGCTTCTA

TGGTTTAATT

TATGGTATAT

GAGTATTTGT

GAAAATAAGT

AATGAAAGTG

TTACATAGTC

TAATACAAAC

TAATCCAACA

AAAATTGCAA

TGAAATTAAT

GAGAGGAATT

GGATTAGTGG

TTTAATAGCA

CTGTACAATA

TATGCTCTCT

ACAGAAAGGA TAAGTAAGAA ACTAGTAAAA CTAGTTATCT CCTAGTGTrA GTAGAAATAG AATTAGGCTr CMTGAGTAT ATGTTTATAT ATAGTTTfTGA CTITTGAATT ATGTITTATGT AAAAATATAA ATTAATCAAC AGAAATAACA AAAAAAGAAG AAATCACAAG CTTTAAAATT AGAAATAATT GAATCTAACA GTATATCAAA GTGATAACGT AAACTCAGAA GAAAAAAACA TACCAGTGGA ACACAATATT AAATATCTTG AACTTTAGCT G'rrCGTGTAT TATAGAATTG CTAACTGTAT ACATTrCAGTG TGTAGGATTT TTA1TGGTAG AGTAAATGAA TAAATATGT7 GTTATAGTCT AAGGACAAGA CAATACTAAT GTACTAATTC GATGTTATTG GGAACTAAAA T[ATCATTCT GGGAGTAGAG AAATATAAAT ATGGAC1TGG CAAATGAAAC AAAGACCTGC AGAGAGATAA CCATATAAAC TCATTATITT AAAAATTATA AGTGTCCTAG CTCTGTTACT GAAAAGGCCT AGAT-FCAATC TTATCTI'GAT AGACAGGAGG GCACCCCT CTCAGAACAT GG317TcCAAA TGCCATTCTC CA~rAAAAGG AACAAGGTCT TCTTGGAGAA AAGACTGATT CTAGGTCTGG AITAGGTAAA GTACAACGT-r AGTCTGGAAT TrCTrFGCTGA ATCAGAAGTA AGAAAGTGCT CAAAAACATG GGAACATGTC ACAAACACAC GTGAGGCAAC TTGAATCCTC ACTGGCCATA T'FrAGGACAA TCGAGCATCA AAAAAAAAAA AAATGTTGAG AATAATGGAT TCTAACACTT AAAACAAAAA ATAATCCATA GCCCACAGAA GGGGAAGAGA GGGGGAGCTC 'rA1TrTACAG ATGAATATCA AATAGCAAAG ACAGAAGAAA TGACAGAATT AGAGAAACAT CAT'ITTGCAA AACACCACTG TAATAATCAA TTCAGGCAAG TATTATTAAT GGATGTATTA CTA~rGCGTA AAACCAGTTfG GGGAACAGGA TATTCATACA GTCTGAAGGT GTCACCCTAA ACATAACTTA YrACAAGTGG AAAATGGTGC CTTTACAATG AAGAAATCTA GCAGAAACCA TCT-rAATCTA GTGATCAAAC TTAGTATCAC CAATAATGGA TCATACTGAG TCATGTGTCT CCTAATATGA TGCACCAGGA AGGATGCAAC GTCATGAACG TrGTATTCTT TTGTAT7CAA CAGACCACCC AGGGTAAAGG CAGCTTTCTC ACTTACTAAT CAGAATTGTT GGTTTTFAATT CATTGGAT T-fTAAGATTT

TTAGCTTGGA

TTGAAAATGT

GTAGTATCAT

CTAAGGAAAT

ACACTGGAAA

AGATTATGAG

CCAATTGTAA

GATTGGTAGA

CTTACM~CT

GAACCATTCA

CTAACTTTAA

GTGGCAAGGC

AAT'FGAATAG

CAACCTAAAT

AACATAGAAG

TGTCAGCTCA

GAGTCTAA

AGTTACTITGT

TATAAAAATG

TAACAAAACA

GTCCATTACA

ACAGTTATGA

GAAATTTATT

CTCATTGTAT

GTGTGTCACT

'TrfACAATCT

CTATTAACAC

GGAATCATT"T

GAGTAAATTT

TAAGATGATT YITATCTT= ATTCAATACT TGCCAAAAAT AGAAAACAGC ATGG1TCTT CAGATTCACA TAGCTTTTTT GCCTAGTAAT TTTATTTAAT ATGACTCTTG AGAGTTTATr AAAGCATAGC AATTTGATTT GGGYCAACCAA ATGAAGCAAA CACTAAAATA MTTFGTGA GAAAACCTGA ACACAAAACT TACATATACT AACAGTACAA ACAAAAAAAT AGTTGCGTTA TCCTITTACA YI7TTGATACA TTATTTTAAT CTTATAAAAA ATACGTGCAT ATAAGOATAA AUTATGGCTC CTTTTGCTGT CTTAAT1TT TTAA'TTA AAATTCAAAA GAATT7TGCCA CTCATCTTTG ccAcTrcAAG GAAAAAAGAA ATGTGTrCGA TATTCTGTT CTTAGTATAG T1TrGGCAAT TTCCTCACGT GTAAAAAGAG AATACTATTA ATAA17CAG TATCTATAAG ACAATATAAA ATTAAAGAAT CTAGCCCAGT AACTGGTACA TGGAACGTAA TTAATAAATC ATTATGGACT TTYTfrCTCA CACCCAAGTA GGGAGGAATC AGTGGTCCCC TAGAGGCCCA GTGTAGAGGT GGCAGCACCA ATCCCTAGGG GAGAAGATCT TGGTGATGAT AATrCCTGAG CAGACAGTTA GCTGAGAATrF CAAGAGCAGA AAAGTAAGAA AGAAACAACT TCT7GCTAAC ACcTT-rcCAC CCACGTT-FCC CTGTTCTGTT GTACTCTGCT TACCCTTTCA TGGATGGAGG CAGAGGAAAG AGAACCAAGT TT1GCTCTTAG TCATJTCACTA TGTrGTTrAA TCTGCCTTCC ATCTCTTA TCAGTTCAAA TTAGAATGTA GACCTGAATr TAAATCCCCG TrTCTGTCAGT TATAATGTGA CCCTAGACAA AACACATTCT CTGAACCTCA GAGAACATrC FFTCA1TrGTA GAATGGGAAG ATTAATCTAT AT7CCACTTG GATGGCAAGT CTTITTATAAA CTTTATAACC TAAACATGTG 208 TGAGTTGCTA GTATCATTAT GTfGGTAAAG T-TATTCTGAG ATATGATAAC AGAACTGTTT TGTCTAACTC CACTAGCATG GTTCAGGTTr AGAGAGTGTG GAATrAAAAG GCTTrATCCT CAAATATGAC UTAAATCCGA TTTTTCTCAT CCACTTTCCT CCACAAACAA ATCCTCAGGA AATGACAAAC TTTACATGGT TAAACATCAG TTTTGT'FrAG TCTTTGACAT CCACATGGTT AAATCATACA TTTGAAAACT GCTTATATTT GTGTTGTCTA TGTCTAAATT GAAAAGACT-r ATTGAGGAAT AGAAGACTAC ACATT1TCA GCAAACACTG CAGGT-TTTGC AGAATTTCCC CAGGCACCAG TCTCCAGGAA TTTATrGGCT ACTAACAATA CTAAGATATG GATGAATGAG GAAATCAAAA TGGAGATCTT GCAAGT[TTG TGAGAATGGG TGAATGGTCC AAATGAAGAG ATAAGTTGTG AAATATTAGT ACAAGTAAAA ATTATUFACA ATGAAAGACA TTTTGTCAAT AGCTATGAGA AfTTACCAT TGACCCAGAA ATTCCATTTC MTCTTCAGA AATACCCACG TAGGTATACA TATAAAAAGT TATTCATTAC AGTATCGTTT 'FrCATAGGAA AAAGTTTTAA AAATCAGAAG CTATCTAAAC TATGGTATAT CTAGGTCATA GAAATCAAAT GACTAAAAAT GTTAATATAA GCATATGTTE TTAAATTAAC TTGGCYrGGG TCTTCAGCAA AATI700CTTC TTAACATTGC ACTCCAGAGT TAGACTTACC CACTCAGTCA CTTATCATGC AGGAGCAGAC TCCTAATACC ACATATCATA GAGCAGAGTA GGACACAGGT TCTCTGCAGG CAGGCAAATC CCAAAGAGAA GGGAGGAAAG GGCTGAGACA CTGCATGGTC AATTTCTTrCT GAACTCTGCA ATGTACGGAG GTGGACAGTG TCCACAAAGA TTGCTCCCCT GGACCCACCA TCATAATAAC ACAACGGCTT TGT[TTGTTT TTGTTUTTGT YITTTGACAC GGAGTTGC TCTTGTTGTC CAGGCTGGAG TGCAATGGTG TGATCTCGAC TCACCACAAC CTCCACTrCC TGGGTTCAAG TGATTCTCCT GCCTCAGCCT CCTGAGTGGA TGGGATTACA GGCATGCACC ACCATGCCCA GCTAAT-TTG TATTT-rTAGT AGAGACGAGG TTTCTCCACG TTGGCCAGGC TGGTCTCAAA CTCTrAACCT CAGGTGATCC ACCCGTC'ITG GCCTCCCAAA GTGCTGCGAT TACAGGTGTG AGCCACCGCG CCCAGCCCAC AATGGCCTTr TGTTTACATC TCTAGTGCAG CACTCAT117C ATG'rrCTTTC AAGAAGAATA CATATTTCAT CTTTATf TATACAGCAA TTAGCACAGT GCCTGGCATA AGGAAAATGA TCATTAAAAG

CTGGGTGAAA

CAGATATTGA

AATCTGGATT

TTCTGAGGCT

CCTATITGAGC

YTTMTAAC'rr

TGCTGAGATC

AGCTCTTrCTA

CCTTATTACA

CTAGACATFF

AGGCAGGTAA

AACCTAATAA AGCTACTGAG GATAGGAACT GCAGACCAGC ATGGAAAGAA CATCATCCTG AAAGGCAGAA GATTTAGTAT AGGCAAGAAG TATGCTrTTG ATGATAAGAA AAGAATCATA TTTGTCTTAT CTTACCTACT CACTTCTCAG GTTrGTCCTT ACTTTCTTTT CTGTTTTATC CACTCTTTCT GTTCT-FrAGA TGACATCAAG TTAACTGACC TTTTATTTTG TCCAAACTGC TGTTAAATGC TATATAGTAT ATCTrTTAGT CCTAGAATTT CCACATGAGT fTMTAAGTr TCCTATTTGT TCATTCATTA TGACCATATT TTTCTCTACA TTATTGAGCA AAATTJCTTGT CTGCACATTC TAACACCTGA ATTATTCTGG GGTCAGTCTC AAAACAGTAT AAGTCACATT GCCTTG1TTC TTAATATGCA AAATGATTTT TGAATTAAAC ATTATAGAGA 11TCTGGATTC TCGAGAGAGT ATTGACTTGT CTTGACTGGA CTCAAACTCC AAACTCTAGG TCCTCTGTAA TGGGCAACTG

AACTATGAGC

GAATATAGAA

TTCCACATGT

TTrGGATCATT

ATCCAGTGAA

TCCATITCTC

TAATTATAAC

TGTTACATTG

TGATTGCAGA

TTTFCCATC

CAGTAATCTT

TG1TTAGTTC T-UTAAGACTT ATTGGCCAGG CACGGGGGCT

CAAGGTGGGA

ACTAAAAATA

CAGAAGAATC

GGGTGACAAA

TGAAGTITCAT

TCTCCTUTTC

TrACGGCAGT

CTTGATGCTA

AGTCTAAAGA

GGATCACCTG

CAAAAATJ7AG

ACT[GAACCT

AGGTCAGGAG TTCGAGACCA CCGGGTGTGG TGGTGGGCGC GGAAGGCAGA GGTTGCAGTG AGCGAGACTC CCTCTCAAAA AAAAATTTAT GGGTCAGCTA TAGATCTGGG CACGTTATAC TGGATTI7CTT T-FCTCATT[FT CCAGCAGCTG AAGATTTGGG AACTYTAGO TYI7TACCTGC CTCCTT-FCTT CCAGATGTAG ACACCTCTCT TTATCATTGT T17CTGTGGG AGAGT-FGGTC CATGCCTGCA ATCCCAGCAC TGTGGGAGGC GCCTGGCCCA CATGGTGAAA CCCTGCCTCT CTGTAGTCCC AGCTACTCAG AAGGCTAAGG AGCCGAGATT GTGCCACTAT ACTCCAGCCT TGGCACTGCT TGGCATCTGC TATGAATACA ACAGAATTTG GGTCTCCCY[ TCTCTGGATT TGGTTFGCCCT AAACTCGGTC CTCTGTITCT CTCTCAGACA AAATAAAAAA TAAT17TCAT AATTTCCAGT TGCTTTTTAT TGCTCTCCAG TGATAAAAAC TACTCCCCCA AAACTGGAAG CTGGAAGCTT GTAATTATGA ATAGACTTTG AGTAGTA7FrC TTCTTTGGAA AAGGATTTTA ACTACTCCCT ATGTACTTCT TTATTTCCTG rr'FrTCTCAT CCGTAATCTT TTTATTTTCA TACTTCCTAA GTCAGACAAT YFrTCCTACTT GAAGATTCAG TGACTGCTAT CAAATGACCC CCATATTACT AAATACAATA TCCCCAACTG CATYFATAAA AAGAAAATTT ACTGTTTATT AGTAAACAAT GTTGTAGAAT AGTAAAATAT TGCTGGGCTT TGGAGCCAGA TAATCAAGGT TAGAATCCCA GATITCTAACT TACTAGCTGG TGTAYITAGTC CTTCTCATG CTGCTAATAA AGACATACCC CAGACTGGGA GACTGGGTAA TTTATGAAGA AAAGAGGTTT AATTGACTCA CAGTTCAGCA TGGCTGGGGA GGCCTTAGGA AACTTACAGT CATGGTGGCA GCAAGGAGAA GYITCCAAGCA AAGAGGGAAA AGCCCCTrAT AAAACCATCT GATCTrATGA GAACTCACTC ACTATCACGA GAACAGCATG AGGGTAACTG CCCTCACGY[ TAATTACCTT CCACCAGTTC CCCCCCATGA CACATGGGGA TTATGAAAGC TATAATTCAA GATGAGATrr GGGTGGAGAA ATAGCCAAAC CATATAATTC CACCCCTGGC CCCTCTCAAA TCTCATGTCC TCACA'FrTCA AAACTCAATC ATGCCCTCCC AACTGTCCCC CAAGGTCT-rA ACTCATTCCA GCATTAAGTC AAAAATCCAA GTI'CAAAGTC TCATCTGAGA CAAGGCAAGT CCCYITCTGCC TATGAGCCTA TAAAATCAAA AGCATGTTAG TUACT-rcCTA GATACAGTGG GGGTACAGGC GTTGGGTAAA TACACTGATT CCAAATGGGA GAAATTGCCA AAACAAAAGA GTTACAGACC CCATGCAAGT CCAAAACCCA ATAGGGCAGT CATTAACATT AAAGTTCCAA AATGATCTCC TTGACTTCA TGTCTCACAT CCAGGTCACA CTGATGCAAG AGGTGGGCUT CCAATGGCCT TGGGCAGCTC TGCCCCTGTG GCTTTGCAGG GTATAGCCTG CTTCCTGTTT GCTTTTfCAC AGGCTGACAT TGAGTGTCTG TGGCTTTTCC ATGAGTATGG TGCAAGCTGT TGGTGGATTT ACCATTCTGG GGTCTGGGCC AGGTGCAGTG GCTCATGCCT GTAATCCCAG CACTTrGGGA GGCTGAGGTG GGGGATCACA AGGTCAGGAG ATCGAGACCA TCCTGGCTAA CACGGTAAAA CCCAGTCTCT GCTTAAAAAA TACAAAAAAT TAGCCAGGCG TGGTGGTGGG TGCCTGTAGT CCCAGATACT TGGGAGGCTG AGGCAGGAGA ATGGCGTGAA CCCAGGAGGT GGAGCTTGCA GCGAGCTGAG ATTGTGCCAC TGCACTCCAG CCTGGGCGAC AGAGCAAGAC TCCATCAAAA AAAAAAACAA AAAAACCATT CTGGGGTCTG GAGAATGGTA GCCCTTACAG CACCACCAGG CAGTGCCCCA GTGGGGACTC TGTGTGGGGG CTCTGACCCC ACATTTFCCCT TCTGCACGGC CCTAGTAGAG GTTCTCCATG AGGGTITCTAC CCCTGCAGCA AACTrrCTGCC TGGACATCCA GGCATITTCCA TACATCCTCG GAAATCTAAG CCGCGGAGGT TCCCAAACTT CAATTFCTTGA CTCCTGTGCA CCCACAGGCT CAATACCACA TGTAAGCCAC CAATGC'rfGG TCAGGGCTrG AACCCTCTGA AGCAATGGCC TGAGCTGTAC GTTGACACCT TrTAGCCTAG ACATCTAGGA CACAGGGCAC CATGACCCGA AGCT[CATAA AGTGGGAGGG CCTTGGGACT AGCTGAGGAA ACCATMT'TC CATCCTAGGC CTCCAGGCCT GTGATGGGAA GGGiCAGCCAT GAAGGTGCCT GACATGCCCT GGAGACGTTT TCCCCATTGT CTrGGTAACT AACATTCAGC TCCGTGTGCA GCACCAACT'T ACYI7ATGCAA ATCTGTCA CTGGT-GAA TTTCTCCCCA GAAAACAGGA TrTTCTFT CTATTGCATC ATCATGCTGC AAATTCAA AC=i~ATGC TATGCTrCCT GrrGAAGACT TTFGCGGCTTA GAAATTTCTT CCCCCAGATA CCCAAAATTA TCTCTCTCAA GTTCAAAGTT CCACAGATAT CTAGGGGACA 209 AAATGTTGCC AGTCTCTTTG CATAGCAAGA TATOAGACCA TCTCAGCTTG GACTTAGTfG AGTCTCTATG AAGTTTCAAA CTrCCCCATG CTGTCTGTTA CCCAG'rrCTA AAGTCACTTC GTACTAATTT ACTGTATTAG TCTGTTCTCA AAGAACAGAG GTTCAACTGG CTCACAGYJTC GCAGCAAAGA GAAGTTCCAA GCAAAGAGGG CTATCATGAA AATAGCATGA GGGTAACTGC CAGGTGGGGA TTATGGGAAC TACAATTCAA

AGAGAGCCTT

CACCCCTM~

ATAGCTACTC

AAAGCAAAAT

CCCCCAGTAT

TrTTCATCCA

ATGTATAATG

CT-fCTTCCTA AAGAAAGTCA CCTAATCTCC ATGGGATTTC TGTGAGGACA AAAAAATAAT AGAAACAACA TGAGCAGAAT GTACAGAGAG GTGACCTTTA CTCCAGTfCC TCCATGTTAC TATCAACATT TTTTCCTGTC TTCTAATAGC TACATITI'G GGTATCTTTA TGCTGCTAAT AAAGACTTAC AGCATGGCTG GGAGGCCTCA AAAAGCCCCT TATAAAACCA CCCCATGATf AATTTACCTC GATGAGATTT GGGTGGGGAC ACAAATAAAA GGT7TCCTAT AATGATAACT AACATAGCCT TTTAAAAAAT GTAGACTA TTTCCGTATA GCACTCCCTA GTACATTTAT TATAACTGAT GGATGCCTCT TGGTGTTGTA TATCATAAAG AATAGTTTCA AATCCCTGAC AACTACTGCT AATATACAGT ATGTAGGATT TCT7TTCAAA GCTTCATAGT TTATGTATTC ATTCACCTAT CTATAAACAT CTATGTACAT GTGCAATTGC TGGATTGTAT GATGTACTGT TTTGCATTCT TGTCGTCAAT GTTTrGAGCA

CAGCATCCCG

AAATCCATAG

ACATGTATITC

TTCATCACTC

CACCAGAGTG

'TTATATTAG

ACCATTACAG

CCTCCCCAT[

TTTGTCT'r CCTGAATGTC ATATAGTTTA TTAGTAATAT GCA'rrTGATG TrC'FrCCATA TAATAT-rcCA TTGTCTGGAT GTACTACAGT TCCAAGT-IrC AACAATCATG AGTAAAGCTG 'TTTCAGCTT TTTTAGCTCC ATTCCTAGGA TGTAAGAAAC TGCCACGCTC TTCCTAACTG CTGTTGCTCC ACATACTCAC CAGCATTTGG TTCCTAGGTA TTCT'ITTTGA AGGAAATAAT TCC1TTfAYFI ATAGTCCATC ATTTAATGAA TCTCCCATGA ACTCTGACAA TCTCCTAAAT TGGTCTGTCT GAAGCATGGC 'FTfTTfT CCAGGCTGGA GTGCAGTGGC GCGATCTCGG TGCCTCAGCC TCCCGAGTAG CTGGGACTAC AGTAGAGGCG GGGTTTCACT GTGTTAGCCA TGCCTCCCAA AGTGCTGGGA TTACAGGCGT 1TrrGAGATGG AGTCTGTCAC TCTGTCACCC CATC1TrCAG GTTCAAGTGA TTCTGCCACC ACACCCAGCTr ATFTTTTGT AUTTTTAGTA CTGACCTTGA GTGATCCACC TGCCTTGGCC GGCCTGAAGC ATGACTGTTG C17TAATCAT CAACAAGTTT CTCATCTCCA TTGGTCAAAG CCATITCAACA CCTCCAAATT TTTCCAACCT CAGCAGTGGC ACTCCCCATG TCGAGACTGG GTAAT'FfATA GGAAACTTAC AAACATGGTG TCAGATCTTG TGAGAATTCA CCACAGGGTC CCTCCCATGA ACAGCCATAC CATGCCAGCT TTGTTCAACA AAAATAATGA TGCATAGTGT CTGGCACAAA 'TTrAGAG TTTTATGTAC CCCCCAAGCA CAGATAGCCT GAATCTATAT TGACGTGTCA CCTTCTATGG GTTTTGACAA CTGTCCTAAA AATCTrrGAT AATTTTCCTG TCTCCATTGT TTCAAACTGG TTrATTTCAC TCAATATFTA TAGAATTGAA CAAAGAACAC CTITGGU-GCT GTTTTTGT GAATTGAACA GATAAGGGTA TGTTTAGTGT CACCAGCAAT GAAAGAGTTC ATAGCATTTT GATCTAACTT GATATACGAG GACAGTTCTG A'TrTTAACT CTGATCCTCC GTTGTGTATC AGGCCCCCTG ACGGAGTCTC GCTCTGTCGC CCGGGTrCAC GCCATTCTCC GGCTAA~TT TTGTATTTT CCTTGTGATC CGCCCGCCTC fTTTTTTFT TTTTrT'TTTT ALTGACAGATA ATAGAGAAAG GGACTCTGTC CACACTTGGT CCCTGTTGCT GGCACACATG TTTTTT TTTITGAG CTCACTGCAA GCTCCGCCTC AGGCGCCCGC CACCACGCCT GGATGGTCTC GATCTCCTGA GAGCCACCGC GCCCGGCCT CACCTCCTGA GCTAAATTGC AAGCTTTFTAT GACACATATC AAAAGCTGTT ATATATTGTT TAGCACTTI'C ATACCGTTAA MITTTCATT GTTATCATTr CCCTCCCAGG CC1TICTCC AATTTGTTCA GTGCACAAAC TCTTTATCAC CAGTGTCTTA CAAA'rrGTCT GGTATATAGT ATCCTATrrCC TATATATAGT ATGGTAGACA AACTTGTGAA TATGTTACAT TTCATGTCAA ATTGTAAGAT TATCCCGGAT TAACCAGGGC TCCCAGCTGG GTTAGAGAGA GATGAGACAG CCCACTGTTG CTGGCTTGA AGATAGAGGA TAGGAAAAAG CCCTCATCTG ACAGCCAGCT

AGGCTGGTGC

TCAGCCTCCC

GAGACGTAGT

TCCCAAAGTG

ATGAAATACT

GGAGCACAAA

ACGTGAATTG

TGTGCCCAGC

rTGTGGACAA

CTCTCACTGT

AGGCACTCAA

GATCA'TrGAT

AAGGGACTITT

CAATCTAATC

AGTAAAAAGG

ACTAGGCCAC

AGAAAGCAGT

AGTGATGCAA TCTTGGCTCA CTACAACCTC AAGTACCTGG GATTACAGGT GCCCGCCACC TTCACCATGT TGGCCAGGCT GGTCTCATTC CTGGGATTAC AGGCATGGGT CATCACATGT GCTCTGTATTr GTTATCTATr TGAAATGCCA CCATAT1TAT ATATA'FUAGC ATGATACCAT ATTCTTrCTC AGTTAAGAGG ACCTCTGTAG CCCTACTCTG TGAAAAATGA AATGAATCCT TGTGTGGCTC AAGAGAAAAT TCAGTCAGTA TCTCAAGTGA GATAGAACAG AACATCCATC TAAATGTTTT TrGAATAAAT GCATACATGA ACCCAAAGAT GCCCAAATGC TGATCCCCAG GCTAATGTGA TTAAGGATTC AGACCCTTGG ACATGAGACC TJ7AAAAAAGC AGAAAACATT AAAGAGATTC AGGGCATGAA AATGACTCTA AAAACAAGGA GTATGAGTGG CCTI'AAGAAA CCTCTGACCA CAAGAAATTG GAT7rCTGCCA ACCACTCAAA TGAGCAAGGA AATGGATTCT CCCCTAGAAC CTCCAGAAAG GAACACAGCT CTGTAATGCC 'rrGAT1TrAG CCAGGTGAGA CCTGTTTCAG AC1TrGACC TATGGAAATA TAAGATAATA AAGTTTTATT GTATGCTGCT AAATTTGCGG TAG'FrTATTA CTGAAGCAAT GGAAAGCCAA TACAGACAGA ATATACAGAG AGAAAGAGAA TGAGTTCTTr CCTGATAAT[ TGTAAATATr TGGGTCTI'CA CTGGACAAGC TITCACAGAGG ATTCACTGGT TCCCTAGCAA ACCAGCATGT CCAGTCCTGC AGCCTCCCT-r TCTTAGGCCC AGCATATGTC AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA CCCTGAGTAG TTGGAAAGAA AAGATGGTTG GAAATGGGTTI GCAC117CAAG TGAGGAAACA AGAGGTAGGA GACCGGCATC TCTTTFCTCAT ATGTCCCAGG CTGACTCTr~G TGAGTTGTTT TCCC'rrGGAG GCTATCGATG ACAGTCACAG TAACCTGATG GAACCTGGAT CATGATGAAA GAAGTAAGTG TCAATGGCTC CGACTTCCAA GGACTCTGAT GTCCCACAGC ACTAGCTAAA CAAAGCCAGT TGGAAATGAG CTTAAATGGG GAATTTCCTG AATATATTCC CTATTGT[AG GAAGCCAGGT TGGCTTCCTT GCCTACAATT ATGCCAAGCA GTCACACTAT AGAGTCCCTA GGGACATGAT ATTAAGTGAT TCTTTrTAACA CAAACAACTT AATAATCAU- TATACTAATA GCAAAACGGC CAACGGCTGA TATTCCACTT GAAGTAGAAT TGGCTATCCA ACTGGAAGAG AAGACAGGAA GACGTGATCT CCAGGGAGCC ACTAAAAGGA T-FGGCACCTG CCTCTGGATT CCCCTIICC TJ7ATATTACC TCTCAGCACT GGCAGGCCTT TATrCAGGA TACAG1TrCA CAAGTATTAT GTCACGTCTC TGAGAATTAT GTTGGTAGAT NITTGCTCCT CTGGCCAGAA AGACCTAGTr TGGAGTCTGG AGTCATGAAG GTGACATACA TGTAGCTAGT GACATAAGTG TAGCTAGTAA AAATAGTGAG TAATGGCCCT GAAA'rrCTAT TGAATGCCCA AAGTGCTGAC CAGGAACAAG CATGCTCTAG CTTATCTCAC AAGGAACTTG ACAATTI'CT TCAAAAATCC TAGTAGCTAA GATI'TCTTAG TAACAAAGCC ACTAAGGCAC AATTATGATT AACTTGACCC TTAGGTGACT 'ITTAAGGACT ATTCTATAAA ATATTACAAC TAATAGTGGA TCCAAGCCAG CACACTCTGC TATATAAGAT TAA'ITGACAG TGTCCACACT GGTAAAATAA GT-rGTFTTCAT AAATACATA GAATTCATTT GCACTTTCTA CACAGCCCCA AGTCCAGAAC TTTCCCCAGA ATAGGTCTAT G=rGCAAT CTGCTACTCC ATACAGAGAT TTGAGTTCAC TTGGCAAT AGTGCTGCTT ATATGTGACC AGTTAGTCTG TTTTACTTAT CTATGCCTTA AACATJTACTA TACTrACTAA CTCCAAGATG CCTGGTCTCA ACTTGACAAA AATACCCCAA GTTGGGAAAT CCTfATGTGA ATATGTAGAT AGTCACAATT GCTGGTTGAT GATGATCTGT CTT7TCCTGT ATGAGAAA ATGGAGATAA AATGGACCAA TCCAAATAAT GGATTAAACA 210 TGGGAATAGG TGAGAGAGAG AGAGGAATAC ATGGTGGCTC TGAGTGTCTG GCTTAGGCAG TAAACACTTT CGTTAATAAA GACGGAAAAT AAAAAAGGAA TAATTGGTGT CTAGGGGAAA ATAATGAGCT CAAGTTTTAA CACTCTGAGT TCCCGGATGT GAGACATCCA GGCGCA~rTA TCCAAGAGGC AGTTGGAAGC AACG11TCCGG AGCTTAGGAG AGAGGCATGA CCAAAAGCTG GTGGGACTGT GAAAAGGTAT GGCCATTCTG GAAAACTGTT TGGCAGTC TTAGAAAATT AAACATGTAC TAACAACCCA GCAATTGTAC TCTTGAGCAT TTrGTCCCAGA TAAATGAAAA AAAAAAAAAG CArrrrrrr ACACAAAAAC ATATACATGA AAGTTCATAG AAGTGTTATT CATAAAAAAC TGGAAAAAAC TGAGATGTCT TTATTGAGTG AATGCTTAGG CAAACGGTGG TCTATCCATA CAATGGAATT ATGCTTAGCA ATAAAGAGAA AAGAACTATT GATACATGCA ATAACACAGA TGAATCTCAA AGGAATTAAT GCTGAGTGGG AAAAAAAGCA CATCTCAAAA TGGTATATAC TGTACTAYIT TATTTACTTA ACATTTTAAA AATAGCAAAA ICATAGAGAT GGAGAACAGA TTAATGGGTA CTGTGTTTG GGATGGGGAG TGAGAAAAGG GTAAGGTGTA AATATAAAGG GGTAGCACAA AAGAGCCTTG TGGTTGAAGG ATTCTATGTC TJTGGTTGTAG TCGTGATTGC AGGAATCTAC ATGTGATAAA ATTGTATGGG TCTACATACG CATACACACA AGAGCATATA AAACTGGTGA CATGTGAAGA AGCTCCGCAC ATTGTGCCAA CATCAGTATC CTAGTrTCAA TATCAGACTA CAGTTATACA AAACATrGTC ATTGAGGGAA ACTGGGTAAA GGGAACACAG GACATTTGGC ATATATTTTT GCAATTTCCT GTGAATCCGT AATTAYT-AA AAATAACAGA TATACTACAT ATCAAAAATT TAATGTCATA AAGUrGATGA GTITTACCTAG TGGATAGCTT TGTTAATATC TGCTATAAGA CTACTGAAAA TGACAGTTAT GCAAGTATAA GCTCAGAGAA CTTTCCTCCC CCTTCGTAAA TGAAATGAGC AAAAGAAATG AAACAGGAAA GGCAAGCAGT ACTGAAAACA GGGAAGGGCT CTTCCCCATA TAACTATATC TGCGACTTCA ACAGCTATTC ATCCAGAAAC ACAGCCTCTT GCGCTAAGAG GAAACTTTGG ATAACAATAT GTTTTCACTC TCCAAGAGAG AAAATGGATA GATTAAT~ TAAGAAAAAA AAAAAAACCT CACCAAYFTC ATGCTGTGGC TrGCACCTTr AATCCCAGCT ACCTACAAGG CTGAGGTGAG AGGCTTACTT GAGCCCAGGA GTTCAAGGCT GCAATGAGCT ATGATTGATT GTGCTATCGC ACTCCAACCT GGAGTACTAA GCTAAGAGCT AAGAACACAG CTGAGAGCGG AGAAGAAACA AACAAATCTG ACCAATAACC CCCACTCCCC TCATTrTACT GGAGTGAGCT GAGACTGCTG GCAAACATGG CCTTTGACCT AGCCTGAACT GTAGCAAAAG TCATCAGATA TTTTrCCACC AATCAACAGA CAGAAGTGGG GAGAAAACAA TCGTAGTTCA TAACTACAAC AAGCAGATAA ACGAAGGCCA TGGTGAGGGA TGGAAGACAT TGTGATATAT CAAAGGCAGG CTCATTTAAA ACTCAACCCA AATITCCAAAC AAAATATATA ATJTGAATATG TATTAATGCC AAAGGAGCTT GAGTGAGCT TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC ACTCTGTTCT CTCCCCATTC TTTGATAGGC ATACTrGCTG TTTfCTCACA GCCAAGGTAC AGAGGGGACT TAGAGGAACT AGAACTCTAA TACACTOCTA GCAGGAATGT AAAATGAAGC ATCTACTTCA GAAAACCATT TTATCAGT CTAGAAAGTT AAACATAGAC CCACCATGCA GCCCAGCCAC TCTACTCCTA AGTATTTACA CAAGAGAAAT GAAAACGTGT CCCCACACAG TTGTATTTAA AGGTGATGGT TAGCCT-TGTG TGTCAACTI'G GCTAGGCTAT AATACCCAGT TACTGAATCA AATAGTAATC TAGGTGCATC TGTGAAGGTA T-rTTGTAGAT GTGGTTAACA GCTACAATCT GTTGACTTCA AGTAAAGGAG ATTGCTCTTG ATAGTATGGG TGGGCTTCAT CCAATCAATT GAAGGCCTTA AGAGCAAAAA GTAAGGTTTC CCGGAGAGAA AGAAATTCTG CCTCAAGACT GCAGCCTCAA CTCCTGCCTG AGTTTCCAGT CAGCCAGCCA GCCTAAAGAT 1TGCTAGGCA TTATAATCAC ATCAGCTAAT TTCTTAAAAT AAACCTC1TF ATATATATTG ATACAATGAA TGGT17ATAGC AGCCTrATTT GTAATAGCCA CAAACTGGAA ACAACCTAAA TGTCCTJ7CAA TAAGTGAATA CATAAACAAA TTGTGGTATA TCCACAATTT TTACGCAGCA GTAAAAAGGA ATAAATGGTT GAATAAGGAA TAAACACATA ACAAGGATGA ACCTI'AAAAC CGTAAGGCTG AATGGAAAAA GTCAGACAAA ACTAATACAT ACTGAATAAT TCCATTTATA T-rGAAGTrCT AGAAAATGAG GACTAACCTA TAGTAACAAA AAGCAGAAAA ATTGCCCA CTGGTGATGG AGGGGGCGCA GGTATTGTAG AGTATCTGAG AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACTTYI7G AGGGTGATTG ATATGTTCAT TATCTTGTGG CATGGTTTCA TAGGTGCATA CATATGTCAA AACATCAAGT TATACACTiT TAAAATGTTC AGTITACTGT ATATCTATTA TACTTCAGTA GAGAGGAAGG AAGAAAGTGG GCAGGGTGGG GGAGAGGAAA GGAAACGAGG GAGGAAAGGC CCTAATAGGA AGGAT17rGG AGTTTAGATT 'rrAAAATGAT AAAGGATGTT TGACACTCTA GGCATATGAC GAATATAGGA 1TATGAGTCC ACAAAAACCA CCAGGAAGTC ATGTATGTTI' ATACTTTAA GTGAAGGATC AGTGGATTAT CAACTCCCTA ATGCTTTGCC TCTCTATGAC TGGCTGCTGT CCT[CTCATC CCAATACTCC TTCCAAAGCC CC3TGCTTAA ATGTAAGCCT TCTTrCCTCC TTrTCAACACA TCCTGCATTC CGTGACAAAA TAAGTTTTCC TTAAACAGAA TGTACAGCAT ATTAT11TGTA CAATTAAAAA TT1TFGGCCA GGTGTGATGA CTCATGCCTG TAATCCCAGC AAT-rTGGGAG GCCGAGATGT GTGGATITACC TGAGGTCAGG AGTTCGAGAC CAGCCTGGCC AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAATT AGCTGAGTGT AGTGTGGCAG GTACCTGTAA TCCCAGCTAC TCAGGAAGCT GAGGCAGGAG AATCGCTTGA ACCTGGGAGG TGGAGGTTGC TGTGAGCAGA GATCAGACTA TJTGCATTCTA GGCTAGGAGA CAGAGTGAGA CTCGGTCCCC AAAAAAAAAC ACA1rTTTT TrAATGTTTC CTCCTTGCCT GTAGGAAAAA GGCTCTGACT CCTJ7AGCCTG GGCATCAGAG CTCTATCTAA ATGGACTTTA ACCTGATrT GTGGCACTAA TTCCATrGCA GTACTTGTCC GCTCACTGGC CTGTGCCTCT CTGCCACTAT TTGGAATA ATGTCCTCTC TCCATCTrGT TTACTCAACT ATATCCAACC TCTAAGGCTG TGCTCCTACA AAGCCTCCCC TGGCTACTTC AGCCCACAGA GATATTTAAC TGCTCTGCAG TTCAGGACAT TCTTCTGACT CTTTAAATCA CATTTACTTA TATATGATCT TGTGATATTr TGTTGACG TGTTrACTTT AATYITCTTC CATAACCTAT TCATTCAACA AACTCAACAA TTATTTATTA AATGCCAAGT TAGAAAAATA TTATTGATTT TATATAGATT ATAGATATGT TTrGAAATTrT ATTTGGCAAT CTGCAAGTAG AAAAATAATT ATAATGTGGT ATATCTGTGA TAGAAGTAUT AGTGCAGAGA CCATGGGGAA CATAATCCAG CCTGGAAGTrF CAGGAGAGAT ACGTGGAAGA AAGGACGTCA GAGCCTTTTT CCTACAGGCA TGGAAGAAAC ATTAAAAAAA ATTTTTTTTr TTGAGATGGA GTCTCACTCT GTCTCCCAGC CTAGACTGTG GTGGTGCGAT CTCTGCTCAC TGCAACCTCT GTCTCCCGGG TTCAAGTGAT TCTCCTGCCT CAGCTTCCCA AGTAGCTGGG ATTACAGGTA CCTGCCACAC ATGGATGATA AATATGATCA TA1TmTG TTCITTCCT CCTCAGTrGT CTTCCCTGAA GAAAGGAATG CCTTTTATAG ATGACAAACT CCCATTCTCA AGAACAAGGA YT-=GACCA A1TFAATTTA ATCAGATGTC TGGCTI'TGAC CTAGAAACAC AGTCACGAAA C11TGGTGA'IT AGAGACCAAT TCCCAAACAT GAGCA'TrCT TAGGAAACAC AGTAAAGATC TGAGAGACCC AAGAGCAGAA GGGCGAGAAA CCAAAAGCCA TCAGTTTGCA TAGGAAACAC C'I1TGTTTAGC CTAATC1Tr TAT'TTTAT ACTCTATTAG TCACTACAAC TAT-TTTCTGA TTFGCTATGGT GATAGATGGT TTAAAACAAG CCTTrCATTAA GAAT-GTCAC ACCATGGTCT CAGTCAAAAA CACCAACATT TTrATTGGTA TTGACAATTA TGGGAATATC CAATTCCAAG AAGACAAGGA GACCTCTGAA CTICTAAAT GAAGACTCCA ATC'ITCCTGA TCTGATGGGA AGCAGCTTGG CAAGATTACC AACCACCACC ACAGAGAGTG GACTCTAAGC TAAGACTAA AAGATAAGTA GAAATTATCC AGGTAAAGAT GTGTACAGAG AAGGAAGTAC ATCCAGGGGA AAAGAACAAT ACGTGCAAAA GTACGGAAAT GGTAAAAAGT 211 AATACTACAT AGTCAAAGCC AAGCAGAGTT CAGAAGGGAT CTGGTGGTGA AAAATACGGC TAGAGAAAGC AGCAAGcIATT GGCTTCTAAA ACCTATGTAG TATCTTGGAC CTTACCCTAA ATGTAATGAG AAGCTFlCTAA AGAATCTTTC ATTTATTCAT TCATTGAACA AATATTTTGA GGC'FITCTGT GAAGAACATC ATTCTAAGTA GTAAAGATAC AGCAGTGAAT AGGACACATA AAATCCTAGA TCTCACAGAA TTGACATrCC AGAGAGGGAA AGGTAGACAA TAAATACATA AACAAATCAT YITAACAAGAT GAMfCAGAC AATGGTACGT ACTGTGAAAA AAATGAAACA AGGTAATGGA CAGCGAAAAG GCACTGGAAG GAAGCCTGCT TACCTT-rGCA TGGYITAGAAA

AGATCTCTCT

ATGTGGGGAC

GGACCAAAAA

TGGAATTATA

AGAGGATTTA

TCTGGAGAAT

ATAATGGTAG

GTCTATAATA

TAGGTTJ7GTA CY-rTGTITG AAGAAAGAGA CCACATGTGA GCTGCGACCT GAAGGATACC GAGAAGCTAG AGAACTTTTG GACTGAATAG CAAATACAAA TGCCCTTGGG TGCAAGCTTT GAAGGCCAGT GTGCCTGCAG CATACTAAGC ACAGAGGAAA ACACTGTTAT AGTAGAGCCA GATAATATAG TCTCTrATAG GTCATAATAA GGCAACCAGA AAAATCACTG GAGGTTTTGC ACTAGGGTGA GAGGTGTGAT YFGTATTTUT TAACTATAAT GAGGTAGGAG TAAACTAAGT TAGGGGCTAT 17CAGTGGCT CTTAGACTAG GATAGTAGTC GTAGAAATAA ATAAAAGTGG CACTCTACTT GGTTTGGTTT ATGGATCATA TATGAGAGTA AAAAAAAGAA AATAAATTAA CCTGAGCAAC TGAATAAATG GGTGCTGTGA ATTGAGATAA AGGAGATTGA CAAATTAATT TTGAGAGGCT TATTAGACAT CCCAGTGGAG ATUTCAGGTG

GTGTGCAAAG

GCCTGTTCAA

ATGCTGAGAT

TTT[ATTCCA

AAAAGATAAT

CAGACAAGAG

TGGGGGTAGA

TAATGGTTCC

GAATCACAGG

AGTGGAGCCC

ATTGAAAGGT AAGGGACAGG GTCAGGTGTG GTAGGTCAGG CCTGTGATCC CAGGACTTrG GAAGGCCAAG GCAGACAGAT CAGTTGAGCT CAGGAGTG AGACCAGCCT GGGCAACATG GGAAAACCCT GTCTCTACAA AATATGCAAA ATATTACCTG GGCATGGTGG CATATGACTG TGGTCCAAGC CACTUGGGGG GCTGAGATGG GAGGATCACT TGAGTACAGG AGGCGGAGGT TGCAGTGAGC CAAGATCTCG CCACTGCAAA CCAGCTTAGG TGACAGAGTG AGAACCTGTC TCAATAAATA AATAAGAAAC GTAAGGGAAA AGGAAATrAA TCTGATCATT GGCAAATGCA TAGTATTTAA AGCCAGGGGA GTAGATGAGA TACTCAAAGT AGGTGAAGAT AAGGAGGCAA TGAAGGCCTA GGACTCTGGT GTACA'rrTAG ATGGTTATAA GAGGAATAGA AACTGGCAAA ATAAGTAACA CTGAGCACCC AATGAGGTGG AGAGGAAAGC CAOGAGATGA AGCATCATAG AAGGCAAGAG AAGAAGGGTG TCAAAGAGGC GAGGCAGTCA TCAACTTCTG GGCAGTCAAA TAATATAAGG ACAGAAAAGT GACCATTGGA TTGGAAATA TGATGAGCAC 'IMGAGTGGA GTGYI7GAGAC AGAAGACCAA TTAGAGTAGA TTGAGGAGAT AACGAGAAAT GAGAAAATGT AACCTGCAAG CACAGACAAT TCTTGAGAGA C'TFITCTGTG AAAGGAAACA GACACAGAGT CTTAGCATGT C1TGTCTTTC TATGGGAAAT GTAAATAGTT TGAGATCAGG GATAGTATTT TATTCTGCTT TTTGTACCTC TACATrACCT AGCATAGAGC TAGCTAATGT GCACTJTAAGT ATGTJ7CTCAA -rcT-rATCGC CTGAATGACT GGATGGGTGA AAGAATGGAT GGATGGATGG ATGGATGGAT GGAAGGATGG ATGGATGGAT GGAAGACTTC TGATTTGCCA AGAAGAGGAT ACTGGTAGCA GAAATAAAAA CAGCACTGGA GAAAGAAGAG TTrAGA'TM TATTCTTTGG TGTCAGTTAG ACAGGAAAGT AAGACATTAG AAGAGTCCTT AGATAATTTA TGTAATTGYT CACTTAGGAT TTTTFAAATGT GATCACTGAT ATrGGACATG TTFCCTAGTGA AGCA1TTTTG GTGTTTCACT GGYJTGAAGTT AATAACTGTA AAAYITATTh7C CCGTTCAGGA CAGAAAAACA GAAAACTTGA AGCTCCTATF AGAAAGYI7CA AGATrcTCTG GGGTTCTITAG GATITTACTGT TCCCAAAACT CTGTCAAGAA CAAGAAAATG ACCTGTATAC TTAACTGGTC TAGGCAACAG TGGAAAGACA ATfCTCAGAG AAGATTTGTT TTAAGAAGAC ACTTFrCCATA GGAATCAAAC AATAGCTTrC AGTGACTAAC ATGGTAAGAC ACAGGGTGTT AGCTCTTTCC ITCCAACCTC ATGGCTGTTG TACCTTACCT TJ7CGACCCCG TGTTCCTGAA ATTGTTAAAT TCATAAAC17 ACCAAGGACT AACCAGCCTC TGGGGAATTG CTGTATACTT AGCAAACTTA CAATGGACAT AT1TATAAGC CATAATGATA ACTGACTAAT CATCATGC AAATGAGT7C CCTrGCCCAG GCAACTACTG 1TGAAATCCT CCTTrTCCAT TTMTGTGTC TrCC'rrrrCC TCTCATCTCT ACAGAAAAAA AAAGTGATTT GATAAACTGA TCAAAGATAA CCTAAGGGGA GAATGCTGTC TGGCCCAACA GGCCAATGGC TGGGAAACAG GTATGAACAG TAGGTTTCTG CACCTCCATG ACAGGAAGCC TCCCTACTCT TACTTCCCAG TAAAATTTGC TCAGTGACCT TT-rATCTAAT AATGTGTTAC TGCTCATGGT ATACTTTrAG GAGATTGTGG CTCTCTAYFA CATTTATATG TGCATCATGC TAGGGACTGG AACCTAGTAA ACAACAAACC CATGAGGTTG GTTTTATGAT CCCAATTTTT TAACTAACTG GTTCAAGGTC ATGCAATTTC TAAGATACAG AAAGCYTTTT CTGCTACTCC ACATTGCTTC CCTAGGTGAG CATAAAGCCA AGGGAAGACA AGCTTAGGAA AAAAAAGGGI CCAGAAACCA CTAGYFTAAA AATATAATGG GAAAAATCCT GATAGAAGAA ACATAGGGAT AAACTTAACA CATTTGTAGG TGGCCTAAAG AAAAAAAAAC TTACATGTAT GOGGAGATAG TCTAGGTGTT CCA1TCTCA CCAAATTAAT GTATACATIT TI1GCTTACAA ATTGTCAGAT AATTACAAAG TTTACCTGGG ACCCCACCAC TCCCCCCAAA ACAAAAAAGG TCTGAAAAGG ATACAAAAYI7 CTATTATAAA GGTGTATFGA TGAAAACAAT CAATGAAACA GCATAAAAAG ACCAGAACTA TACCTAATTA AGGAAATACC CTCAACTGAA AATGAGAGAT GGGAAAATGT CATGCAAGCA AAATTAATCT kTAGGCACCA GAAATATCAT GGTGCCTGGA 'TfATATTGT GTCCAAATGT GAYI7GTATTT GCAGGCTCTC GACTTCATTT CAGACACTGT AGTCCCCTGG AATTA1TCCA TTrATGTAGC TTrGTTCATT CATGGCACCA GGTJ7GCAGAT CTTCTTCTCT TAAAAAGTAC AAGGGACAAA ACAGTATA TTCAACAAAC A1TTATTGAG GTGTAGCACA TATTATTTCA TTTAATCCTC CAGAAGAAGA AACTGATATT CAGAACCAGT AACCAAGAGT CAAAGACATG ATTTTAAACC ATCTGAGGCA TTCCGCGAAA AGAGAAGGGT AATGTCCTAA ATAAACAGCT 1TrCCTATYJTA ATTCACTTTA ACAATGTTAA AAAAAAAAAA ATATGTAAAG AAACTAAAAG ATGTTAATAA ACCATCUTAC TGGATTCTAA TA1AATAG AATACAATGT CAAACGAAAT ATCYJ7AGGAA AAATATAAGC ATATATGAAG AGTGAATGGG ACAGAAATCA AGGAGAGTCT TGCCTGCCAG TrAATACTAG TGTAGCAATA GGCAGCAAAG TGATGAAGAT TrAAGGTATG ATAAACATGA CATAAITCAA ATCAGCAGAA ATTGGCATAG ATAGGGTTAA GACAAATAGC TAATCATTAG AGGGGAGGAA GGAAAGGAGG GAGGATAAAA TTAGGTTCCT GCCTTFCATCT TACATTAAAA TAAATTCCAG ATGTATTACA M~AAATm- TTAAAAAAA GAAACCACAA AATACTTGAA GAAAATATAA GTTGTTATAT AGTCITIGA TGGGAATI1 TTTT-I=TC AGAGACAGGG TCTTGCTCTG TCACCTAGCC TAGAGTGCAA TGGCATGATC ATGGCTCACT GCAGCCYJ7GA ACTCCTGGGC TCAAGTGATC CTCCCAGCTC AGCCCCCCAG GTAGCAGGAA CTACAGGCAT GCGACACCCC ATCCAACTrA TTITATI T'ITGTAGAGA CAGGGGTCTr GC1TGTTTC CCAGGCTTAT CTCGAACTTC TGCCTTrCAAG CACCTCAGCC TCCCAAAGAG CTGGGCTGAT GGGACATTTT TTAACATAGT GCCACATTAC CATAAATGAA AAGCTTGTAA AATACTAATT TTTAAAACTA ATATATATCA

GAAATITA

TATATGAATA

ACTAAACTGC

CTTATCAAAG

AAAATCTGTA

TAAACAAAGT

CAAAAAGAGC

TAAAAGCAAT

AAGTAAACTC

AGAATACTGA

TAAAAAGCAA ACACAAAAAA TrGTAGCAC UTATGACAAA C'T[TACAAAA CAGTAAGAAA ACAATGAATA CTCCCAATGG TCAAAACAAA AAACATAAAC TATGCATATA TGTATGTGAA TCAAAGAAAT AAACATCAAA TAAGGAAATA GCCTTTTCCC GCTGCGAATG TTCAGAAAA AAAAAAAAAT CATACACCTA 212

TATATOTATA

AGTATTCAAA

AAAG1TTAAC

ACAAATAACC

GTTCGGCATG

TAATTAATAT

AGCACTTTGG

TGAAACCCTG

CTCGGGAGGC

ACTGTACTCC

iTITATATACT GCCTATfl7GCA

GTACATTGTG

TAGCCTGGCC

TI'TCACACCA

CCTFTAGTCAG

GGATGAGTTT

TCTCCAGGAC

CTGTCCTAAC

AGATCAGAAC AC11TTAAAAA TATTTATAGG CCAGGCACGG TGGCTCATGC GAGGCCAAGG CGGGTGGATC ACCTGAAGTC AGGAGTTTGA GACCATCCTG TCTCTACTAA AAATACAAAA ACTAGCCAGG CATGTTGGCG TATGCTGGTA TGAGGCAGGA GAATTGCTTG AACCCAGGAG GTGGAGGTTG CAGTGAGCTG AGCCTGGGCA ACAAGAGCAA AACTCTGTCT CAAAAAATAA TAATAAATAA CTGACCCATC AATTTGTCCA GCATAATTAG GCATGTGTAC AAGGGTAC ATA'IrGCTTT TAATGCTAAA AAAAATTGGG GAAAATGCTT TAAAAATATA GTACAGTCAT ATAATCAATA GTATACAGCT ATTATTTATT UTCAGCCACT TAACAACATT CTGTTAGGAT ACGCAAGCAC CGTGAGGAGA TCAGCTATAA CTGCTCCMI GCTAATAACC 'rrCAATGGCT TTTAAAGAAG TAAAAAACAA

CTATAATCCC

ACCAACATGG

ATCCTGGCTA

ACATTGTGCC

AAATAAAATA

ACACAAGAAT

GATTAAGACT

GTCCAAAATA

AGTATCAGTG

AGGCAAAATT

CCCT-rAAGAC

TTTGCCCCCC

CACTTCACTT

CACTCAAACC

AGGTAAAAAG GTrTrACTG CTGTCGCCTA GAATGGGGGG CCTCCCACCT CAGCCTAGTG TTTATTTT GTGAGATGGA CTGTGGCCTC CCAAAATGCT CATTAACATG AGGAACAGTG TAAATGCGGT TGATGGGTTA TCTCATCAAC AATCAAAATT ACATTAAAAA ATTCCCCCAG GATAGGAAGC ACTAATGAGT ATITIAT7G CTGTTGGAGG TCTCTGTTAC TTAGCTCAAA CTACCCY17TT CAACAACACT GCCCTAACCA TGGAGTACAT TCAGCC1T-TC CTTATCAAAC CTTCCT-rTAA ATAAGTATCT TCTTCCCCAA UrTAGCA'IM TCTATATCTC CAGGCCTACC TCTATAAAGC CTAGCTTTTT CTCTGAACTG CTAGAAATAT TTTTCTCTCA TTGGCCATT-r TTTATTACCT ACTCAATAAA AATrTCTTT TTTrGAGACA AGGTCTTACT AAGTGGTGTG ATCACAACTC ACTGCAGCTr CTACCTCCCA GCTCAACAGT AGTAGCTGTG ACTACAGGCA TGTGCCACCA TACCCCACTA CTTFrCAT ATCTCACTAT GTTACCCAGG CTGGTCTGCT GATCTCAATT GATCCTCCCA GGGATTACAG GCATGAGCCA CAATATCTGG CCCCAGTAAG C1TTAAGGC TTC117TACAC TAT1TI'ATCA GCTAGGGCTr TGCATGGAGT AGGAGTTTAG ATCAATGTGT GAAAATATI'C AGAGCCACCA AAAACAGATA T1TATGTCTAT GAGTAAACAG CCATTTTCTA ATACAGGAAA CCACAAAACA TTGAATGGTG CAGGAGCCAA CCAATTTT CATCCTGATC CAAGTTAGCA AACTGCAAAA GGAAATTTGA GTAGAAGCAT TTCTTATGAA GGCTGTCTTG ACTGGATCAC TGCCAAATGT GTGTGT-rTAT GCTAATCCTC CACCTCAGGC AACACACAGT CAAGGATCCT ACCAAGTGTT ACCGTCAAGT GTCTGTTGGC AGCTCAAGGC CCCAGCGTTG TTCCCT7GCA CTAGGGAAAA GACATATTCC AGGTACAAGT ACTCCCACY[ TGATGCTACA GAGGAGTTGC TGAACTTTGT GTCATTAATC TCTCTTCGTT AGATCCCAAC CCTGTTTAAA TCCCACTATC TGCCTACTCT GGGTCTrCAC CAATTTACTA GATCATAGTT GGAGAAAATC TACAAAGCCT TGCTCCCYUrT AGATrAAAC AGGTCTCCGT TTAAATTTAG AATTGCTAAC TTCAAGCGGG CCCTTATGCG ACAGTATGCC TGTCAGTCAT ACTACATTTC CTCAAUTCCA TTCATGTGAC TGCTCCATAC CCTITCCCTCT CTCTTCATAC TACTATrATC TCTTCCCCCC TCCCTCATTT TTAACTGATG ATCTTGTTTC CTATTTCTCT GAGAAAATAG AAGCCATCAA AAGAGAGTTT CCACAAACTC CTACTGCCI1T ATCTAGCCCT GTACCATATA CTTTGCATT-F CCTCTCATTA CCATGGATGT ACTGCCTATC TGTGCTTCTA TCTAAGGCTA ACCCTJTCCAC TTCAGTTTTG AATATTATCA GCTCTTACCA ACTCAAGGCC ATTGCTCTAG CAATTCTCTC A'FrCTCTCTC ATMTCTTCC ATCAAGTTTf CC1TrCTTC AATTAACAGA GTAGCTCCTA AAGGGAAAAA AAAGTCTTCT TITCAATGC TCATCATCAC TGGCCATCAG AGAAATGCAA ATCAAAACCA CAATGAGATA TCATCTCACA CCAGTTAGAA TGGCAATCAT TAAAAAGTCA GGAAACAACA GGTGCTGGAG AGGATGTGGA GAAATAGGAA CACTTITACA CTGYI7GGTGG GACTGTAAAC TAGTTCAACC A~rGTGGAAG ACAGTGTGGC GATrCCTCAG GGATCTAGAA TTAGAAATAC CATTTGACCC AGCCATCCCA TTACTGGGTA TATACCCAAA GGATTATAAA CAATGCTGCT ATAAAGACAC ATGCACACGT ATGTfATTG TGOCACTACT CACAATAGCA AAGACTTGGA ACCAACCCAA ACGTCCAACA ATGATAGACT GGATTAAGAA AATGTGGCAC ATATACACCA TGGAATACTA TGCAGCCATA AAAAATGATG AGTTCATGTC CTI7TGTAGGG ACATGGAGGA AGCTGGAAAC CATCACTCTC AGCAAACTAT CACAAGGACA AAAAACCAAA CACTGCATGT TCTCACTCAT AGGTGGGAAT TGAACAATGA GAACACFTGG ACACAGGAAG GGGAACATCA CCCACTGGGG CCTGrrGTGG GATGAGGGGA GTGGGGAGGG ATAGGATTAG GAGATATACC TAATGTTAAA TGATGAGTTA ATGGGTGCAG CACACCAACA TAGCACATGT ATACATATGT AACAAACCTG CACGTFTGTGC ACATGTACCC TAAAACTTAA AGTATAATAA AAAAATATAT ATATATATAT AAAACAACTA AAAATAAATC TFrCTFTrTCT GCAGGATCAG TCCATCACCA CACACACAGG CTGTGTTTTA TGUTGTTCCC CAGCTTAAGA GATCGTTCTC CAGATCCCAC TGCTCCTTCC AGTTGTCACC TCAGTTCTCC ACT7CTTTTT GCTGATAAAC TACTCTAACT AGTTACATAT GATTTCTGTC CCCAGGTCCC CTCCCTCAGT TG=n~GAAC ATAATCATTT ATATCATTTA TCAT1TTTCAC TCTAATTGCA CAACCAAAAA CTCCC1T=T TTTI7AGATGG AGTCTCACTC TGTCACCTAG GCTGGAGTGC AGTGGCATGA TCTCGGCTCA CTCCAACCTC CGCCTCACGG GTTCAAGTGA TCCCCCTGCC TTAGCCTCCT GAATAGCTGG GATTATACAC ATGCACCACC ACACCTGGCT AATTGCTTTG 1TMTGT-rTG TGTGTGTGTG TGT-TTTT TT-TGGA CAGAGTCTCA CTCTGTTGCC CAGGCTAGAC TGCAGTGGCA TGATCTCAGC TCACTGCAAC CTCCACCTCC TGGGTTCAAG CGATTCTCCT GCCTCAGCCT CCCGAGTAGC TGGGACTACA GGCATGCACC ACCATOCCAG GCTAATT TTGTATTYrTC AGTAGAGACC AGGTTTCACC ATGUTGGTCA GGCTGGTCT-r GAACTCCTGA CCTCAAATGA TCTGCGCACC TGGACCTCCC AAAGTGCTGG GATTrACAGAC TTGAGCTACT GCGCCGGGCT ATfrTGTGTT T1AGTAAAG ACGGGGTTTC ACCATGTTGT CCAGGCTGGT CTCAAACTCC TGACCTCAAG TGATCCGCTC GCCTCAGGCC CTCAAAGTGC TGGGATTACA GGAGTGAGCC ACCATGCCTG GCCATAAAAC TGCCCTfTGT TAATATGACT GTTGGCCTGC ACATI7GTCAA ATCCAGTGGC ATTCATCTTA CTCGGCCAAC CTACGGCATT TGACACTGTC TGTCTTr-CCT TCTGTTCCTC TATCTGTT[C CAGTATACTG GCCTGGCTIT CYTFTACCT CYTJTATATG CTCT-rCCAGT CTCAGGCTCC TTTGGGGATT TGAAGGTATG TTGCA1TIG CTATTCAATG AATAATGACA AGTAATGATC ACTTAAGACA YrAAGTGGTC AGTTCCTTTA CTAGGATAAA AATAATlC YI'CCCAACAT GGGGCATATT CCATTTrcCAG TCTGACTGTT CTGTGTAATC T-rTGTAT7CC Tr7GGCAGCCC c'TrTATATC AGiTTCATCTA

CTGTGCAGGA

AGCTGAACTC

AACATAAATC

CTGAAATATT

ACTCTGTAAT

AATTGGACAA ACATfGCAC TGGTATAACC AAATACAGYI ACCAAAAATA A1TTCTGTAA GAGACTGAGA CGTCTACGAG AAGGATACAC AGGTAGATTT GAAT1TCAGA TAAACAACMA TGTATCTTAT CTGGCAATTC TACCTGGTAC AGAACTAATC AAGTTCTTTG GTGATGGAAG GGAGGTATTT CTGTAATTAG *GAACTYTGG CTTGACTCTT TAGGYT-C AGAATTAGTA ATACTTTTrT AGTATGTCTA CAUrCTCTTG AAAGATCUTG AGTCACTGTC 'rrCCTCCCAG rTMTrATCC TGGCCCAGAT CTGCAATGAA CACACGACAG CAGGAAAAAA AAAUTAAAAA CATCTGAAAA AGCTTITrGTA GGAGAACTTT CTGTCTGCAC TTTACATCAG AACAACCUTG GTGGTGCTI7G GTAAGAGATG CCAGGACCAG TGGTACCCAC 213 AATCCAGGGG GGATGAAGAT CTAAAAGAAT GTGATCTAAA GCGTCTAGAA GCTGTGCCCT TGGGAGCACT GCCAATACCC

GGGTGCTTTG

AAAGAAAGCA

GTGGGAAGTG

AGCAAGGAGC

ATGGGTGCAC

GGCCAGACTT

TGGTCCACTC

GTTGGGCTGA

TCAAGAGAGC

TCTTATCCTT

T1'AGTTCAAT

AGGGTACATG

TCAACTCGTC

CCCTGGTGTG

TGTGTATGTT

TI7ATGTGTGA

T-CCTTCAAC

GCTGGCGCGC

TCAGCCTCCC

AGATGGGGTT

CCCAAAGTGC

AGTAAGGCAT TGCACTGTGA TTCAGCATAA AATAACAATA CCTTTGTTTA GAATGTGGGA AATGTCTTCT GAAAAATGGT CAGGCAAAAC TGACTAATCG GGGGTCAGGG ATACAACCC( CATGAGGTTC ACTGTGACCA CTGTGGTT[FA ACCCCATAGT TCCACATAAA ACATAATCAA AAAAATAAAC TCAAGTTTCC TCACTAACTr TGGAGCAAGA 1TTGAGAATT GGATGGCTAT GTTTTGTTCT TrT'rTATTA GAGAACTATG GT1TIrTATTF TGCACAACGT GCAGATTTGT TACACAGGTA TAAATGTGCC

ATTTACATTA

TGATGTTCCC

GAACCAGCCT

TAAGTGAAAT

CATGAGTGTA

AGTGGTGCGA

AAGTGGCTGG

TCACCATCTT

TGGGATTACA

GGTATTTCTC

CTTFCCTGTGT

TGCATCACAG

CCAAGGATTT

TGCAGGTTTT

TCTTGGCTCA

GATTACAGGC

GGCCAGCCTT

GGCATGAGCC

CTAATGCTAT CCCTCCCCCA CCAAGTGTTC TGTITATGTG TCACTTGCTT ACAAGAAACA ATGCTCAGAG GTGGGCYI'AA TCTTTTCTTT TTTGAGATGG CTGTAACCTC TGCCACCTGG ACCTGCCACT GTCTCCGGC~I GTCTTGAACT CCTGACCTCA ACTGCGCCCA GCCCACAGGT AAAACTAAAG TGCTAAACTG AAAAAAAAAA AAAATTTCCC AATGAAATAT ATGCCAGTTT TCACAAGTGT CTATAGAACA ATGGCAAATr TAAACAGGTA TACAACAAAA

TGTAATTTAG

ATAAAATTCT

CTCTCAGCCA AAGGAATACC AAGCCCAACA TGACTCATTA TAAAACACAG ATCTTAAGAC GTTATTTTAT CCCAAAAAAT AAAGTAAACC TGAAAAACTA TTCTCTCCTC CCTTrGGAAT TGACAAGCCA GACTCTTTGT AIT1CTTTGA TATA'TTCA

ATAGGTAAGA

AAGCCCCTCA

GT'TTrGGCCA

TCAGGCACAA

AGCAGAGAGC

AATGGCCCTG

TT17IACTGA TC17GCTCTG

TCAAGCGATT

AGGGAACGTC ACGGAGAAAA AGTAAAAAAG CATGCTTGGA TGCATCATAT GTfGYFICT CTCCTGGAAA TACAGCCAGG ACTGATCAGC TTTTCACAAC TTGAGGGCTA TTTCTGCGCT ATAiTTACAC TTrAAGTTCT ATGTJTGGTTT GCTGCACCCA GTCCCCCACC CCCCGACAGG ATAGA'rrACG TTTATTGATT AACACTFCAC AGATGGATCA CAGGTAGGAA GAGCAGTATT AGTCTCACTC TITACCCAG GTTCAAGCAA TTCTCCTGCC AATTTGTC 1ITTAGTAG TGAATCATCC TTCTCAGCCT YTrCAAAGA CTAAACTTAA TGATAGACTG TT1TACAAGA TGAAATTTTG ATAATATTTG ACCAACTGAA TGGACTCC1T GGATTGGGGG TAGGTGGGGG CTGAATGTCA GCATTGACAC CAGGCCCTGG AAGAAATCAA CAAAGCTGTC TCTTGTGGGG TCCAGGAGAG ATTTAACTAA TTGCCCAGGC TGGAGTGCAG CTCCTGCCTC AGCTTCCCGA 'TrTTGTAGAG ACAGGGTTTC CTCGGCCTCC CAAAGTGCTG TCTCTCTGAA GCTACTATCT TATCCTATTA GTTTCTACTG AAGTCTTTGA ATCCACCTAT AATGTACACC TflATATGTGT GCTGTAACCC AACCACCT7G CATATTTGGC TCACAGTAAA ATAAAGAATT GGAAGGTCTT TGATTTGTAG CTTTGCTACT GAAATGCAGA CTTTCCTCCT TATTGAACTC CTAGGTGCAA TTflTCACAGA CTAGTCTITC GTCTGATTAA AATCTGCTTA TGGCCCAAAG GAATTTCTCC TATTAGTTGT TJTTTCATATA CC1TGGGGT TGGCAATGGA TACGAGATTT ATGTTGCTCA

AAAATTGACA

GAGGCTAGCA

TGGCGTGATC

GTAGCTGGGA

ACCATGTTGG

GCATTACAGG

AGAGGCTTCA

ATTCCAGGTC

GACTTAAAAG

TGATGGATAT

GGCACATGTT

CrrCTTTAAA

TCATCAGTCA

TAGATTGCTA

TGCTGTACAG AATTTCCTTC TCTTTCCAAG TG'ITITITrT TTY-FTT TGAGGCGGAG

TCAGCTCACT

TTACAGATCC

CCAGGCTAGT

CGTGAGCCAC

TCAACATAAT

TTTAGATAAT

CCCCACTCCT

CTGCCTGTAA

TTCAGGAACT

GCAACCTTCG CCTCCCGGGT

ATGCCACTAT

ATTGAACTCC

CGTGCCCAGC

AAGACCCTTG

AACAACTCTT

TCAAGTTATC

C17CCATTCC

CATGAGACTG

TATTGTATAG AGTFFTGGCTr CTGAGCCAGC YJ7CATATCTG TCCATTATCT AGAAGCATCA GCCCAGCTAA TTIrGTATT TGACCTCGTG ATCCGCCCAC ACAAGACATr TACCGTCTAT GTCTCCACAA CTCCT-rATCT TCAACCAATT GCCAATCAGA CCGCC'T1CT GGACTGAACC CCTAAAATGT ATAACATCAA TGTTGCAGAC CTTGGTCACT TT-rTCATTGA CACAGGAAAA ACTGAGGTCA TACAGTTCAG GGATCACGTG GGACCTATTG CATAGTAGGT GCTCAATACA CGCTCTCAAA G3TTAGTGCT CCAGTCTCAC TCCCCTATTA TCTGAGAAGT CTrCCCTCAC CATfATTCTA GTCTTTTTCA TAATAGAACA AAATTGCTGG AGAACCCAGG ACCTTGGAAT T-rCATTAATr CATGAATTAA TGCCTCTTAA GCACTCAGCT CATGTGAGTC TGAGATCAAG TCTATTTTAG CACTGTCCCA TATGTTATTA AGGAAACTAG GGGGAGGCTC TTCTTGAAAA

ATTCTTGGCA

TGAATTAACA

CACCACGCTT

TGTTATCTCT

GTTGACTTGT

TCATTTCCCC

GGGGGAAGAG TG'ITCTCCTA ATATTTTTCT TCTT-rAGCCT TTAGTCCCCC ATITGCCTGCC TACAGTTGGC AGAGACCATC TGITCTCTCA CTGTCAGGAA CTGTCTCAAT TCTTGAAGTT CAGAGTCAAA AAAGAAGCAA GTTI'TCCTAG CTCITTGATC AACTITTCAAA GTTACT-rC CATTTGAAAA T17ACTAAGT CACCAGGAGA TGG1TFATAC TGAGAAATAT CCACTCATAC TCTTCCTCTT CAAC'TrCTT CCATATACAC CCTATTACAG GGATATAGTC UTACTCTATA GCTCAAAAGG ATGACCCTAT CAGAAACCTG CACAGTATGT AAAACATTCT CACCAGAGGT TCACTrGTGT A1TTCCACCC TAGAATGGAA GCTCTACAAA AGCACAGAAT GTATCATTT AACTTTAGAT TCTATTTTCA CACCCAGTGC TTGACACATG ATTTGAAGTT AATATTTATT TATCAAGTGA TTGTTTTAAA ATCATGACTC ACTCAACAAA GTTATAAGAA TAAGAATAGT GTTACAGAAT TGGTATACAC AAGCTGACCA TAATCAACAC ACCTATTATC A'TTT'rrGC GACAGGTTCT CGCTGTCTCA CCCTGGCTGG AGTGGAGTGG CATGACCACG GTTCACTGCA GGTTTrGAACT TCCAGGCTCA AGCAATCCTC CCACCTCAGC CTCCCACATA GCTGAGCCCA CAGGTGTGTG CCACCATGTC CAGCTAACTr 'IMAATrCT-r TGTAGAGACA GGGTCACCCT ATGTTGCCCA AGCTGGTCTT GAACTCCT-rG GCTAGAGAGA TCCTCCCTCC AAGGTCCCCC AAAATGCTGG GATCTCAGGC AAGAGCCACC ATGCCTGGCC ATAATCAATA CACT-rTFAAG AATGCTAGAA TGTTATATCA GATGCATACT TCAGCACTAT CTCAAGCAAA CTGGGGTGTG GGTTATTCTA CATATAAAGT TCAGCAGTGT TGTTCCACAG TCCCAAACTC CAACTGAGGT CAAATGTAGG GTGCAGCAAG GTCACTGGGG CTGTCATCAA GGGCCTCTCC T-rGCACTCTT GCCAACCCTG TITFCYGATT GTCTCTACCA CCATGAGTCA CCAGCAATCT CCCACAGTCA CTrGTT'TAAA AGTI7CACAAG TAT-rGTGTGA ATTGCAGGCA ACCCCT-rGAC TCCCTGAT-rG CCTGGTCTTC 'FrCCTrGGGC TCTACCATTTF TTrTTTCCCCA GCACTC1TTTC TGCTGCTCTA AMTI'AATT CATGCAATTC CATATGTGTT TCTCTATCAT TCTTCATCTC TTTCCTCTCC CTTCCATCCA ATITGTTTG TCTGTTTGCT TGCT-FGCTrG cTTAATACA TTTCTCTITT TCTGAGAAGG CTTGAGTCCA AAACTCTCAG TTACCTGTTG T-rCTGTT-FCC CGTTAGTTAA TCTCCGAACC TTCATAAA-fr AAATCTGACA AAGTCCCCTG ACTAACAAAG GAAATGCACA AGTCACAGTA AAAGGGGCAC ACACAGAACA CAAATAGACC CAGGGTCTTT TCTGTTCATC ACTCAGCTT TT~ATAGGAGA TCCAGGAGAA ATGAAGTGGA AAGGGAAGTG TG'FrGAGTTA CTATACAACA CAAGAGTAAA CMTCTTATA AGTGGTAATT TITI1TACA GGAATAATTG AAAATGGAAA T-FACCTTCTC TACTCATAGT AAGTACTCAG TGCGTTCTTG ATGGGATGAG AATGTGT17~G AGCTTTAGTG TAAGGCAGAA TTCTGT'rrAG TCTGCCAGTA TTGGAGAAAA ATAAAACACA AAGGGACTGA CATGTAGGAA GTGGCACCTG GGAGGGTCTC AATTCTTCCT ATTACAAAAA TGCCCCAGAG AAATAAAAAG CTTGTGTACA TGYI7GAGATG GGAGAGrrCT CTGGCCCCCC TCGCAGGATG TGTGACAGTG GGGTGGCTCT CTGCTGCGCC ACCATGAGCT CAAACCCCTC ATAGGAGGGG GAGCACACAG GCAGGAAGGT GCAGGAGCTG GGCGAGCTCT TTGGGCTCTG GCCCCGTGGT 214 ACTGTCTAGA GGTGGGTGCC TGCAACTCCT GAAAGCCCAA GTGGGCATGT GYJTACAGTGC ACTCTTCAG C1Tf-GCTGTC TGCAGC11TAA GCGTTAACCA GCTCAGTTTC TTCTrGGTAC CCAGGTCCT-r GTCTGGCATC CAGGAAGAAT CAGGYITACAC ATGGACTTIGA AGGATGAATG TGGGAGTTT7 ATGGAGTGGT GGAGGTGGCT CTCAGTGGGA TGGATGGGGA GCTGGAAGGG GGATGGAGTG GGAAGATGAT ATTCTCCTGG AGYT-fGGCTG TCCAGCAGCC GATCTCCTCT CCAGTCGTCC CCAGCCTCTC GACGTTCAGA TGCTCCTCTT CTCTCCUTCT CTGCCATGCT GTTCTGCCGT TCATCTGCCT GTCTCTCTCT GGAGCCTGGA ATTrGGGG'17 TATATGGTAC ACAATAAGGG GCATGGCAGG CCAAAAGGGA ACITI-TTAGG TGCAAAAAAC AGGAATGCCT CTITCTCACTT AGGGCTATAG ATTTTCAGGC TTGAAGGTGG GGCCTTTACC AGCGAACCTG TAT11TCCCTG TCTCCTGTGC ATATCAATGT AATCAAATAC TGGGCTGATC CAGGATGTTr CTTTAGACCA ATTATGGGTA AAATAATTTA CATTCAGGTT TT-rATAT'rrG cT-rT-GTCAT TTCTITTUTAA GCAATCATGT AAAATATCTA TACGACAGTA ATAGATGATA GCGAACCTAA T7AAAATTAC CAGAAACTTA AGAATCTCTA ATGATTrCAA CTGTAACTAA GGTTATrCT CTTTATGTTG AACAATGTTG GGAGATAAGA CACAAGAGTT TCTGAAGTAT TTCAGAAACA CAAAGAGGGA GGTTATATAA ATAATATT TTTCCTACnr TGGGAAAATG AAAGCTAGTC ACAAAGTTAA ACGAGTGGTr AYTTAATAT YFAAAATACA GGCTTGGATG TATTTCCTGT TAAAGAAAAT AAAATGCAGA ATAT-rcAAAA CGTCTGACCA CCCTrCTAAG AAAATGCATC TCTGAGGTAT TrTTCCTTAG AAGTTATTGT AAAAATCCTG GAGAAGCTTG AACACAGCAA AGCAAACAGG ATGCAGAGTT TAATCTGTGG AAAGCTrAGG GAAGAAAAGC AAATCATTAA AAATAGGTCT TCCTCTGAAG ATTTTTAAAA CGCAAAGAGG GTGGAATAGC AATGATAATA AAAAAGCTGG CATAGAGAGT GGCACAATTJT GCTGTGCCAC TGAGCTGACT GGATGTGTTC TGAATTTCTA GGCATTAGTG TACCTTTCCA CACGCATTCT CCCTTrAAAA AAAATGCCCA CACACTGAAT ACTTTCA TGCAATTTAA AATAAGCGCA CCATCTAGTT TACAGAAATT CACTAGAAGT TATTTATCCT AAAATAGCAG AGATCTAGAA GAATTTTrGAG CTCTAGGACA ITTTTAGACAC ACAGAAAGAA GAATCTGGAC AAGTCTTGAC CAGACATGAC AGAATAGAAA TTTCTTT-FCC TA1TfATCTC 1TTGAATAAA ATTTCAGGA TCTTACAGTG GACAAGTTrG TTATCTACAC ATrGTGAAGC ACATITGATTT CTCCTCTGTA GCCTTAGGAA GATCTGAGAG GTGACTGAGC TGATTGAATG ATCCGTGACC GCTCTACTGG GACCAGTAGT AGAACTTTAC TGGTGGAGAC CTGCTGGAGG TTTGAGAGCA GACTTTGAAA ATTACTAGAG CTACACAGAT ACTGTGTGGC TAACTGGATT ATGU-TAGAG GCT-rTCAGAA CTATGCTGCT GCTGCTGCAG TGTAGCCAGG ACGCACAGAG AACATCTAAG GCTCTTGAAT GGGGCGATAG GGACAGATTr CAGCAGCCAT CTGACTrCAG TGCTCATT'Ff GATGCTTTCC CTGCAGGGTG CAGTGTGCAG TGTGCAGTGT GCAGTGGTGG GAGGCTCACA CAGGAATACT TGCTTCTGTA GCCCTAATTT CCGGTTCAAA CTCTGCATTC ACCTTGACAG ATTCTTTCCT TGGCCAAAAT TAGTTAGGC TTCTGGGCTT TCTCYFATGC CCACCTGCAG AcT1TTTGGT AAAATCCAGT TTTAGTAAAG AGCTCTGCTA AGTCAGTTTA GCAAGAATCC CCACCTCAAA AGTCACTATC TCCCTCCCTG GTAGTGTCTG GCTTGTCTTC AGCGAGAATT CTATTAGGTT CTGTTAGAYI' AGAATCCTCC TfACCCTTGA TGCTTCCTCT TAGTAYJ7TTT TCATCCACTG ACTCCTrGAC CCACCT-rGCT CCTCGGCTAT AAATTCCCAC TJ7GCCCATAC TCTGCAGTTFA AGACTATT CTCCCCACTA CTGCAAAATC CCATTFGCCAT GGTCCCTATA CTATCTCAAT GGTAATGAAT AAAGTCTGCC TTACCATGCT TTAACAAGTA ACATTGAACC ATTTITJrTCT TTAACAATCT GCTGCACAAT GAGATrACTA AAACTTrATT CCATT1GCC ATGCTGGATG TCCTCAATGG AATGGCTCTT GTGAGCACCA AATCATTGTG AGAAGGAAAA CCCATCTCTT ACAGCCCCCT GTAACGTGAT GTATGTTACA TGTGATGTAT GTTACATAGT ITTTTTCAT GTTGATCACT TTTTGCCCAT T-17CCTATAT C1rrATCAGTT GGAAGACTGT GGAAGTTJ7GT AGTACTAAGC CACAAGATGA CTAAGAAGAG TJTGAAAGGGC AAGTGGGGCT AAAAACAGAT YTTGTTTGAC TTACCCCACC ATTCCCCCTA TCATGGGGCT GAATCTGCCT GGAGGAAGGiA GCATCTFTAT CTTTGTACTG TGAACCACAC AGTCTAGCAG CAGCACAGCC AAGGCACTrG GGGTTrCATG AGACTAAGTA CATGCAATTC TATTGTAAAG GCTTAAAATA TATACAACTG ACCCTfGAAC AACATGAATT TGAATTGCAT GGTCAGTrAT ACGCAGATTT TCTTCCACCT CTGCCACCCC TGAGACAGTA AGATCAATCA ATCCTCT-fCC TCCTACTCCT CAGTCTACTC AAAGATACTT GAAGTCTACT TGAAGATGAC AAGCACAAAG ACATTTATGA TGATCCACTT CCACTTAGTG AATAGTAAAT ATGTTTTCTC TTCCTCCTAA TTTTTrAACA CT-rTCTrCTC TCTAGCTTAA T17ATTGTTA AGAATACAAT CTATAATACA TATOACATAC AAAATATGTC 1TAGTTGACT GTTJ7ATGTTA TCTGTAAGGC TTCAGGTCAA GAGTATGCTA TTAGTGGTTA AGTTTTCGAG GAGTCAAAAG GTGTATGTGG ACT-rTCAACT GCAGGGGGGT GGGCACCCCT GCCCCCATGT TGTITCAAGGG TCAACTTTAC TGCCAAAGGC AAGCCTTTAC ATCCACTTTT TCCATCCCAT CAGTAAATGG AAAAAGATAG CTACAGTATC CCTGCGTCAA ATCT'rrrrTT TTGCAGATCA CAAATTGGCC ACTCACCTrG CTCTGTGAGG GGTAAAATGC CCCACTTTCT TTAGTAATAT TTAAGTTAGA TAATATYJTAA GTTATAAAGT TG'FrCTFTGT AATCGUTAAT TGTAATTT'FF ACATAGTTTrC T1TCAAACAG AAATAGCATT TTTGTTAGAT AACCTCCCGT ATAGATGATG AAACTCCTTT TAAGGGCTAT CTGAATTTTA ATTCCTTGAA AAGGCAGAAA TTGGATAGCT AGTAGTCATA AATGTACTGT GGCTTCCCCC AACCATCTGG GCTATATAGA AGCTGCATCC TfGGACTGCA GTAGAGGAGT CTTACAAAGC ACAGAGCAAC TTCTCTCCTG GG1TGCGCTA GTTATGATGG CAATTAAA TGTGTACFI17 TACCCAAAGA AAATCCTTAT TATCAACAAT CACAATGCCA TCATAACCAT GGTATAAAAA ATTCAAAATG TCCCAGCTGA AGTGGAGGCA AAGACTCAAG TTCATGGAGT CAGAGTTTCC TTGCTATTCC TCTrTCAA ATGACCATTT AGTAAGCACC TGAAGAAAAT ACTATGGACG GCAUTGAAAA GTGAAGATAG GTT~rAATCTU CTCGAAAATC TAATTCTCCA GATGAAACGC TGACACTTAT CCACCCCACA GACCCTATAG CAGATGTGTC ACTGGCCATC ACAITITGACA CAGAGAAGTC ATAACTCAGT CAGCACAGAG ACAT1TCCAT GAGTTTCTGA ACCATGGACA GAACGTCGTC TGTGGGACAT GAAAACTGGA ACTTAGAGGA CAGGCACATC TGAGAAATGG GCAGMTAAA GGCAGAACAT AGCACATATG TGACTGGGTT TTAGAAGCAA ATACAAGA CGCACTCTF7C TJTCATCCTAA ATAATCTGCA ACCAAAGCTT CCAAAAAAGA CAAT'17AGGA ATGCAGAGGT GAGGAGTAGG GAGGGGAATG GGATGAGAGA GAGTGGAGAT TAATGGTGGG CAGAGCGAGG TTTAGAACTT AGTGGTITrCT TCAGG1F7CTG AACTGAAATT TGTATACTGT AAAGGCACAA ACACCATTTT TAACAAAAGT GAGCAGGACT TCCTATCTGG TTCAGAAAAT AGGTGAATAA ATAGTACGAA TTATTAAAAA TAATAATTTC CACTTATACA TAGGAAACTr GATAGJAACC ATGATAAATG CTTAACTCTrF AATCTTrCAAG GAACTCTGCT AGGGATATAA TATITATAAAT CTTGTTTTGC AGATGGAGAA ATTGAATTTT AACCCAAGTr ATCATAACCC 'TrAAATGATT AAATGATACT GTTACATGAG AAAGCTGCGT ATCTGTTrTCC TGGAT-17GTA GCCATAATTT GTGTCTCAAG TCCCTr'FfGC TGCCAGCTAT CTTGGGTAGG TGTGTTCCCT 'rrGGGCTGTT TGATACCCCC ACATrATCT lTTTrrrC TCTTTG TTGAGAGAGT CTTTCCCTGT TGCCTAGGCT GGAGGGCAAT GGCGCGATCT CGGCTCACTG CAACCTCCGC CTCCTGGGTT CAAGTGCT7C TCACGATrCT CTTGTCCCAG CCTCTCTAAT AGCTCGGATT ACTGGCATGC ACCACCACGC CCACCTAAUT TTGTATYUr AGTAGACAAG GGGTTTCTCC ATGTrGGTCA GGGTGGTCTC AAACTCCTGA CCTCAGGTGA TCTGCCTGCC YITGGCCTCCC 215 AAAGTGCTGG GATTACAGGT TAGTTrCCCAT GACTGGGCTT TfGTGTCCTG AGCCCCTAGT ATTAAAAGTC TAATTCTCTT GTATfrATGAG CCTCTATCCA ACCTTACCTA GTAGGTAAGT CCCCAACCTT TTTGGCACCA GTGGTTTCAG GATGAAACTG AGATCCCTCA CACATGCAGT ACAGGAGACA GAGCTCAGGC TAACAGGCCA CGGACCAGTA TGGCTGCTGC ATGTCUTCTG AAATTACTTT CTI7CATATTJA TrTTAATAAT GTATATAAGT AAATATTGT GATGAAAATA AAAGCCTTCA GATGCTGGTr ATAGGGCAGT TATGAATACT TJ7AGCTAYITA TGATCACTAC ACTATACAAA GTCCAGTAAA GAGAGAAAAA AATGCTGTCA AACGTGAAAA 'TrTTTGCATT AAGTCTATAC TCCCCCAAAT TTTTACTTGG CTATAAGGGG GTGAGCCACC ATGCCTGGCC CCAAAUTTAT CTTTAATGCC CCAAATTATC

CTGCTTTGAT

TAGAGGCTAT

GGAGAAUTGA

GTGATTFTGTA

CTGGAATTGT

GGGACCAGTTF

TTCCACCTCA

TCACAATAGG

AGTAATACTC

CTGGTCCACG

TGTAGCTACA

G3AGTTGTGAA

AAGTTTCCTT

GGCATTGGTA

CAAGGTGAGA

TAATGTTAAC

TAAAATGGGG

TATCACATTC

GTTTTACTGT

TGAATCAACA

CTGGAATTCT

TAAACCTCAA

CCTTTCTGCA CTTGCTGGAC CCTCTCCCTG GGAAATGAGA GTCTCTGCTG TTCCTGAATG GGCCTCCTGG ATGAGACCTC GAGATACCTA TTTGTCTCAA AATCA11TGAA ACCAAF[AAT CCTCAATTCC CCAATCCAGC TGTCAAGGCC AAT11TGTTCT AGCTGTGGCA TTTTCAGTAA TGGTACTCTA GGTTAGCAGT YTGTGGAAGA CAAT1TrTCC ATGAAGGGCT GGGCAGGGGA GATCATCAGG CATTAGATTC TCACAAGGAG TGCGCAAGCT GTGTGCACTC CCATGAGAAT CTAACACCGC TGCTGATCTG -ATTGCCTAC CGCTCACCTC CTGCCGTGCA GCTCAGTTCC GCGCAGGCAT CAGGGACCCC TGTrGCTAGG TATAAGCATC TCTGTATGTG TATCTGATGA GATATAAATT AITTGATTAT TGAGTATCAC ATATAATTAT ACATAAACTA GGAATATGCT AACTATGACT TTCATCTTAG CGTAGTAAGA GGGTGCTAAG GAGTTGAGAC CACTGGGTGA TGAAAGAGTG TAAAGATTY[ AATGTGATTG GGAGCAAATC AATTAACTTC TUGAAGTCTr ATATGTAAAG CTCTTCTGCC CTGTATACAG TAAATGCTAG ATGACATAAA CCTCATAAGG TITITAAGTAT TATGCAAGAT AATTGAATCC ATGATGTCCG ATTATTTTAG CTACTTCCAA TCTTATAGAG AGCAAGGCAG ATCCCAATTC CCAATGTGGT AAACACTTIC TCCTTTC1T CCTACTATTT AACAACTGGT CCTTrTCTTAT TCTTY7TCCT CCTACCAAGA CCGCAGGATC GTAGTAGAAG TTCTCTGTAT TAC1TTTATA CTCTGTCACA ATTTAGTTAA ATTCTCAGCA T-fCTGATCCT TACTATACAA GATTCCCT GTTrCCTCAT CTCCATGTGA GGTAAATGAA TATAAAAACA AAACGAAACA AAAACCTCTT CCTATTTACA TAAGGCCCCA ACGTAATATT TAGTGATATA TATTAATGTG AACAAGGAAC TAACGAAGAC TGGGAAGAAA TTCACAGACT TGAGAGAAGA AATGGCAGGA TTTCCTGGGA ACAATCAT GTAACGTCAA AGGTGGTAAA AGGTCAAATA GAATGAAGAT GGAGAATACC GGATTTTCTT ACAAAATGAT 'rrCCCAGGAG ATCTCATCAA ATGCACGAGG ATACCTTCTC AGTTJTCACCT AGTGAGTAAA AGACTGGTAA CATAGCTCAC TTFACAATITG GATAAACAAA ACTAAACAAA CAACATCAAA ATTTCAGAAA AAATAATAGC AAAACAGAAA TCAAACACTC AAATTTT-rGG TCCTTCTG'Ff TATrTCATT[ TGGATACTCA GTGAATGTTA ATTAACCAGG AAACTTAAAA GTTATTTCAA TTATGAACCT CTTCAATCCT TCATCAATTA ITTrTGAGTAT TCTGGTCT7A AAAACATCTC TTTCTTCTAC AAACYTCTGA AAGAGATGAA CACCTCCACC TACACCAAAA TAATGTGCTT TGCTGGCCAA AAGTACACGT CCAITITTTAC TrAACAGTCT AAGGAAAGTC TGGTGCAAAT TACTATAATA ATCTGGGTTG TAAATGGTTT CTGAGGTGAG AATGAGATCA TATTTTACAA AAAGTTTC ACTACTTAGT ACAAGCTrAC AAAACTCAGA CCACTCACCA GAAAAAAATC GGCATTTATA TAGTTGTGTT ACTITTGGTT TCCTGCATCT TTT7CACATCT GGCTCATTTA CATCA=TC TTCATCTTCC AAAGTGGAGT TAGCTACTAC ATTAGGTAAG GTTrACTTCAT CAATCACCAT ACTGTTATAA TCTTGAAAGT GAATTTCTTT GGACCCTCCC TTGAATGCAG TTATACCTAG TAAACCTGAT CCACAACCAA GATCCAAGAC YTTTTI7CCCA GCAAATTTCA CTTTGGCCTT TGTGAAATAA GCCAGGAGGT CAAAGGTACA TTCCCAGATT T1TAAGCCTC CCTCATAAAC ACCTGTAATC AGATCAGAGT GAGAAGAAAA GCTTTTTGAA ACTATGTTTT CTCCAGGGAA GTTCTCTY17C AACAAGATGG TTT[CACTAC TGATAACTTA ACATGCTGGA AACCTGGTAA TGTI7TCTATG ACTTTATTTT CTAACATCTT CMTAAATCT TTAGGCATAG CATGCTCTTTr GGCAGCTCTC AAGGAGGGCT GTTYI'CCATG TGGCTCCAAG TTCCTTGAAC TGCTGGCTGC ACTGAGTGGA CTGTCTGTGT CTTGAGAGGG AGCTGCATTF TCCATTGACT TATGTTCCCA CAAGTGATCC TGAGGCAAGT CAAATTGTTC TGCAGAACAT TITCTGTCCC TCTcT-cTcc TTTGACTT TCTGAGACTG ACAGCTCTTT TGAGGAATCC AGGGTCAAAG CTCCATCTCT AATGGGTGTT AATTCATTTT CCAGATGGTC TJTCTATAGTG AAATTAAACT GAAAGGTCAT CCTCTTA-rrA AATGCACACA ATCTTTAAAT TCAGATTCTT CAACTTCTGG ATAGAATYI7G ATGATACACA CAAATCTGCC TCAATTATTC AA'rrAGTTTr GTTGGGCCCA ATTTCTCTTT AGCAGCTTAT ACATGGTAAC AAATATTTAG AGATATTTCC AAATGACTTT TTAGACGTCT T-rGGTCCTCT TTcCAAGCAG CTCTGGAAAG AAAAAAAAAA AAAAAAGAAA GAAAATGATG ATTAAAGCAA AATGGCACAT TUCACTAAAG TGTAATATTA AACAGCCACC CCCACCCCTC CCTGTCCCAC CATACAGCTG CTITTTCTTA AAAAGT[GTG GGOAAGAGAG AGAGATAAGA GATTTGGACA CTCATACACA CCTTAAGGGT TCCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG AAGAACAACA GCAACCACCA CCACTACCAC CTGGACAAAC ATAAAGTCCA AGATATTCAG ACAGGACAGC CTAGCTACY-F GCTGTC1TrC AGCTGTC'rrG ATFI1TGTGTCC AACCATATrC ACCCCCTAAG CTrCCAGAAT AACTrCACTTr CTGTCTTA CAGAAGAGGT GCAGTATTT-r ATTGGTAA GTCAGCGTCC CTTTAAAAAC ATGCATAGGT ATGGCCTGGT GTGTGTAAAT TCATCCAAGA CTTCACTCCA AACATTTAGT CGAGAACAGC AGCCCTAAGT GTATAGAAGT GGGGGTAATT TGGCAATAAT TAGTAAAGAC TAATTCGGTG GCAGAGCAAA CGCAAACTAG GGCACTGCAG TAGTTTGGAG AGACCTGTAG AAATAAGAAG CAACTTTATr GAGAATCYFC TATCTACTGC GCTAGACACT ATACCATCTG CCTCAATTTr CACAGTTCTG GCAAGTGGGA TC1TTGTTCC CM~ATACAA GAY-FTACAAT TTGGGGGAGA GGCGGGTCAC CCAGTCCCGC GGCTAGGAAC GCGCCTC1T CCTCTCCCAT CACGCTGCAA GGCTrGGAGT CACTTCCGGC TGCAGGTCCC GGAACAAATC CGACCCCAGA AGTGGGGACT TCTGGCCCTC ACCTCCCCAT -FrGAATGTAA TGITTTACAGT GATCCAGACC TGGGGATGCT TGCT-FCCCGA CGTGTCCTGG GATCGCGCU- CTGAAAAAGC TCACCTCACA ACGCCTCCTC CGGACCTAAA TCGCGCACCA GTGAGTCGAG TCCTCCAGGG GCTAGAGAAG CCCGACT'rrC TCCGGCCT TGAGGGACCC GGGCTCACCA AGAAACCAGC CGCCCTCCTC TCTATGGTT TGGAGCCGGC GGAGAGCGCG CAAGGGTTGG CGGGACTGCG AGTTrCCGGT CTGGGCTTUG GCGGGTCTGG TTGAAGCTC TCCTGTTTGA CGAAAGTATG TCTCAGGAAG GTGCGGTCCC AGJCTAGCGCG GTTCCCCTGG AAGAAITAAG TAGCTGGCCA GAGGAGCTAT GCCGCCGGGA ACTGCCGTC.C GTCCTGCCCC GACTCCTCAT ATCCUrCCTTr GGTJTGTCACT TCTACCTAGA GAAGGGTGTG GGCGGGTCGC GAACCTCT CTUCTGTCCC TUCAGACCCA CCGCCAGGCT GGGTTATATI' ACCGCGGCCT GAACCCCCTC 'TTTCTGT CAGTGAGTGG GATGAAAAGT GAGGGACTGG AGGGGAAGCG ACAACCGTGG TAGATTUAAG TAAGGCTUTG GCCCTGGAAA GCCTCGCGGA CGTGTUCTGA CCCAAGGT TAGCAGTGGA TGTGGCGTTr TCYITCCATTC CTTCTTTCAG TTUTTCTGTA CTCGTTGCTT GCAATTAAGT GTAAATACTT TTGCTAGTGG ATAATGGGGG AGGCAAGGAC TGAGACCTGC GGTATGACGA TAGCTCTGGC TCT-AATAGT TTGAGGTAAA GCGAGATACT 216 CTGAGCTTIT GTCTCCCGTA AAAAGGGTGG TGAATATGAA TAAGGGCTTTF CTTAGCGTTA TAAGAATTAA

AGGGCATAGT

TCTCAGACCT

TCTTTCTGAA

TCGTCCGGGT

CTTTCATGGT

CAAAAGAAAA

ATGTAATCAC

AGT1TTTGTG

ACATTCAAAA

ACACGGAACG

CCCACCTAGC

GTAAATGGTT

T-rCTGATTCC

ACCCU-ATCA

AGTTAAGAGG

GATCTAAGCC

CCTACCTCAA

TGGCCCAAAT

GTCTTACACT

TGMfGCYTT CTfCACAGCG

ATAMTCATG

TTAGCTTCAC

T-rCATGTTTT

TTTTGGAACA

CTCAAATTrc3

AATTCTTGTA

ACCCTGTCAC

T-rccTCAGCC

AGTAGAGATG

CCTCCCAAAG

ATTCTTrGAT

ATGGTGTATA

AAGTTGGTAA

TCTGTGGTGT

C1rTC AGAGT-rCTTC

GCAGCACATT

AAACCATATG

AAAGTAACC1

ATAGAAGTCA

TAGGTACAGA

ACACTTAAAC

TGATTCCTCT

TTTGCACTTC

TCACAAACTG

AAACTATGTC

CCTCTCACT[

GGAAAAACA'

TTGCCCTTCT

GATCTTTTTG

GTCACTTCCT

TGTATCACAT

GTATATTTTC

TTACCCTCAG

TT'FrAAAAAT TATT1TAACA GCATTTrACG

GCTGGTAATT

AGTTAATGAT

TTACTGTGGT

CCAGGCTGGA

TCCCGAGTAG

GTTTCACCAT

TGCTGGGACT

GATTCTTATG

TGAAGAATTT

GATAGGTATG

GAAATCTTTA AAAGATGTTfC AGTAAATAAA AATGATTT-FC CTCCTTCCCC T1TCTTCTT TTTTGAC AAG17CTCAC TCCTCTCACC CAGGGTGGAG CGCTTGTTGT TGGCTTTCAA CTGTTGGATT TGAGGCGCTT AGCGCCTTCT CTJTGATI7GGT CTCATGCCTT TGTGGTTGTA AATGTGCCTG GAATCCTAGC TATATGTATC TT'1CACAA CAThITGAGCC CAGCTTTATA CAATTACACT r TCACTTGAGA GAATCTCAAT ACTGCACAAA TATTGTGCAG CTAAAGCCCT TTCACCTAGG CATTAGCAAA ATCTCAGAAG GTGCCAAAGC CCCCTTITT ACTGCCGTCT TCAAGGAGTT TCAACTTGAA AACAAATAGC CACCCTCAAA TGCGTGCATA ATGTGTGTGA GACATGGTGT TAGGCT-rTGG GAGAACAGAG TCTTCCCCAC AAGCTTATAG AGAGACTTCA TTAAGTTGAA AGTCAACATr AAACGACATA TI7CAAAAAAG CCCAAACT~rC CTCTAGTTI7T CTTCATCTGA AAACCYI7GAA TCCTCTCTGT CTCACACACC CGATCAGTAA GTTCTATTGT TTGAATCAAT CCGTTTATCT CCATCCTCAT TGCTACCACT CTGATTCCAA GGAGTAYJ7AA TAGTTTCCTT GTTTCTACTC ATAATTCATT AFITCCAAAAA T AGATCTCGTC ATITCCCTrT TTAAACCACT TTACCTrCAA GGTTCCAGGT CTCATACCTA GTTAATTAAC TACACTCTGT TCATGAATAC ATTAGGCTCA CTCAGCCTGA TTTGTTFCTCT CAGCC1TTTTG CATATTTCAT GTTTATGTCT TAGAGGGGCT TTTrCAGAGC CTTCAATCTT AGGCAGTFrCC CCCAAACGCA TGGCCTGT[C AGTTTCTAA AAAGCACATT ACCATTAAAA GAAATGCTCT CACTTCTACA CATrATGT-rG CAAAGTTCAT AAAGGCAGGA TGTTGAT-rTT CACCTAGAAC AGTGCCTGAC ACATAGTAAG CATTCATTAA AGGGCTAAAA ACTTGGGAGT CTAATTAGAC AATACTTTTr 'TFCAGCTTAA TGGTAGTATT AATGAAAAAT 17GCAATAAA TCTACAATGC CATTACCCCC CAAAATCTTT TATTATTTTC CAGGCCU-AC ATGAGCTTr TACTGAAATT GACCTCA111T TGATTrGCTGC

AGGACTATGG

GTGCAGTGGT

CTGAGATTAC

GTTGGCCAGG

ACAGGCGTGA

GTGT-rGTTAC

ATITGTCGTGT

TAAGTAATAT

GGAAAGAAAA

GTTTTTT

GCGATCTCAG

AGGCACGTGC

CTGGTCTCGA

GCCACCGTGC

AGTAAAACAT

ATTTGTAAGC

GAAAAAAGAT

ATTTCTTGTA AAGTACAATA GAAATG'ITGA TGGTGTGCAT CTCTAATCCC AGCTCCTTGA GAGGCTGGTA GGCTGCAGTG AGGTGTGATC ATGTCACCGC ACTCCATCCT CTGCATGTCT GCATAATCAT AACTGACTAA T1TTCATGAG GCCAATTCTA CCCTACTGAA TGTAAAAAAT AAGATTTCGG AAGAGGAATG GTTTGTTTGT 7rrGTITFGAG ACGGAGTCTC CTCACAGCAG CCAGGTTCAA GTGAY[rCTCC CACCATGCCC GGCTAATTTT TTGTATCTT ACTCCTGACC TCGTGATCCG CCTGCCTCAG CCGGCCGGGT TATTCATTTI7 TCTTAUrAAC TTCTAACAAT TATTCTAACA ATTATTCTTG TGCTATGTGC AGAAGAATTT CAGTCAAATA AGAAGGTGAT GAGTGACTfrA GGTATAAATT ATAGAAATCG GAAGTACAAA CTGGGCATGG TGGGAGGATC ACTTTAGCCC AGGAGCTTGA GGGTGACAGC AAGACCGTCT CTCT1TTTT GGCGCGATCT TGGCTCACTG CAACCTCTGC CAGCTGGGAT TACAGGTGTG CGCCACCATG CACCATACTG GCCAGGCTGG TCTTCAACTC GGATTACAGG TGTGAGCCAC CCCACTJTGGC AATCATAAAC CTGTGGATTA TTGTAGCATT TJ7GAAAAGGC AAGTrc3TCC CTGGGCAATT CCTAATAAAT CTTAAGTTTT TAAAAGCAAA GTCATTGCTT AAATTrCAAA AGGGTTTrTAT CTATGATACT AGTATCTTCC FTAATTATCC TTCGTAAGTA AAATTG=rT AACTGTATGA TAGATGTGTT CT[ACAGT TGTATTCCCT TTTTFTTTGA GACGGAGTCT CTCCCAGTYrT CAAGTGATTC CCCAGCTAAT TATTTI7GTAT CTGACCTCY-F GTTrCGCCCAT CCCGAGCGAG ACCCTCTCTC GTTTCTCATC TGTCAAAAAT T-rCAAAATAT TTCTTTAATG ATTAAGCCAG TAAUrTGAGI TTTT'IMTTA GGTTTGTTCT TACTCATTGT CTCAACATTC TGTACTGA TGTTAAGGTC TGAAATGTAA CTG'rrCTCTA AATTCCAGCA CTJTAAAAGT'I ATAAACAAAT TGTAAATATT CTGAATAGCT ATCAGCCTCT UfGTCTAGGT GATAACAAAT TACTTGATGA GATTCATTCT GCTTTTCTAT TTAGAGTTCA ACCTAATrrT TT1TCCTTT ATCTTrGCTC ACTGCAACCT GGA'ITACAGG CATGCTTCAC TGGCCAGGCT GGTCTCAAAA TACAGGCGTG AGCCGCTGA( ATTGCCCAGG CTGGAGAGCIA CTCCTGCCTC CATCTTCTAA

CGCCTATGCT

TCCTGCCTCA

TITAAGTAGA

CTAGGTCTCC

TAAAAAAAAA

ATTTCATGAC

TGTITTCACA

CCAATTCCAA

GAGTAATGAA

TGACAGTTGG

CGAGTCCCCA

TGTTACAGCC

TTAAATTACA

AAACGTTAGT

AACATGTTTA

YI'ACCATTTG

TCTAGTCAGA

CTTGGTI7GTG

GGAGTGCAAT

GCCTCCTGAG

GACGGGTTCT

CAAAGTGCTG

TAAATAAATA

TATGCATAGT

ATACTGTTA

TCTCTTATGA

TACCCTATTA

ATTGAGCATA

CATACCTCGG

TITTATAACCT

TTTTGGATAA

TGTTACGA17 GTGTCA1TTA

GAGGAAGTTC

AGAGAGTTFA

GAATATTCAT

TCAGTrACTr GAAATGAACA ATACCAAAGT GTTTTGTrGA AGACCTATAT AAAACATGAT GAAAATGCTU TCTAAATTGC ACTT7CTCAT TTTCATGTCT GACTGCTCAG TTTACTCATA TTATAATTTG AATCTACGTI' GTTIrTTGTTG GAGTCTCGTT CCACCTrCCA GGTTCAGGTG CACGCCTGGC TAATTITFGT CTCCTGAGCT CAAGTGATCC 3CCTGGCCCCA GAGTTTGIT GTAGTGCGAT CATAGCTCAC AGTGCTGTGA YI'ACAGGTCT TGTGTMT GGGGGACAGG GTCTTGCTT GTCACCAAAA TCACTGCAGC CTCCATCTCC CACGCTCAAG CAATCCTCTC GGTGCGTGCT ACCATGCGTG GCTAATITC TATTTATATA ATGTrCCCA GGTGGTCT AACTCCTGGG CTCAGACAGT ATTACAGGCG TGAGCCACCA TGCGTGGCAT AA'TTTTT AAGTGATTCA TGTTCATTGT GGAAAATATG AAACATATAG CTGAAATGGT TAAGA'rrrrG ATGAGAACAG TCTCATCTCA ATITCTTCGTA CATGTTrATC TACATTAAAA TTGGTGYI'AT TGAACATTYIT TCATGTTA AAATGTCATr TI7AATGATGG

TIGTCACCCA

A11TCTCCTGC AYITTTrAGTA

TCCTGCCTTFG

TG'TTTTGTTT

TGCAGCCTGA

GAGCCATGAT

CTGGAGTGTA

ACCTCAGCCT

T-17ATTTTT

CCTCCCGCCT

AAGTAAATTA

AAAAACAGAA

TrrTCCGTATA AT1TTTGGAAA

CAGATCCTAT

GGTGGAGTG

CTCAGTCTCC

GAGATGGGGT

GCCTCCATAA

TCAAGACAAG

ACTCCTGGGT

*GCT1'GCCCTG

GTGGTGCGAA

TCCAAGTAGC

GGTAGACATG

CAGCCACCCA

*T-TTTTTATC

AAGATTACAA

TTCCTGCCAG

CT-1TGTTT

TCAATAGATG

AATTrCATTCA

TGATGTATGT

ATGCAGTCTA

CAAAAGCTGA

TCATCAGTCT

TTTTGAGTTA

GTGTAATGGG

CAGTGGCGTG

CAAGTAGCTG

TTCACCATGT

GTGCTGGGAT

ATCTCACTCT

TCAAGCTATr

TGTTT=GTT

CATAGCTAGC

TGAGACCGCA

AGGTCTTGTC

AAGTGTTGGG

TTGAGTATAG

AACATCTAAT

CCTATCCATC

AACTACATTG

TACACACACC

TT1T-GGCTA

GGTAGTATTC

TATTTAACTG

CTACYJTAATA

GTCCACAATT GTTGGATATG TAGGTCGTTT CC1TICTCTC ~TT~TTTT G1TTCTCTGT ATAGAATGTG GTATTFTGAA AGTGTATCAA GCT-17AGATT 217 TrGCATTTAA TAAAGGGCAG TGGCCTTTGT TGACTGACAT GACAATATTT TTATAAAATT TGTTATTTGC TTTACAGAAA TTFTGAAAAT TATTGTAGAA ATGTTTT7AC C=fCTTTTC ACAAGTGTTA CCAAAGGTAT AATACTATTA CTCAGTCTTA GATGATFITAT TATTAATTAT GGCTCTCT[ AATAAGGAGT AAGTAGATCT CATGTGAGAC TATAATGGTG TUACAGGCTG GGCACGGTGG CTCATGCCTG TAATCCCAGC TGAGGTCAGG AGTTCGAGAC CACCCATGGT CAACATGATG YI7AGCTGGAC ATGGTGGCAG GTGCCTGTAA TCCCAGCTAC GCCTGGGAGG CGGAGGTTGC ATTGAGTCAA GATCGTGCCA

CTCATATGAA

CCTGAAAATA

TTCTAATATA

TTAGTGTGAT

TCTGTGAGAG

AAACCTCGTC

TTGGGAGACT

TTGCACTCCA

CCACCTGACA TTGGAACAGA CATGTTATAA GGAATCTAGC TCAAATATAT TCAAAATAAA CATTAGGCAG TTAAAAACTG GCTGAGGTGG GCAGATCATC TCTACTAAAA GTACAAAAAA GAGACAGGAG AATTGCTTGA GCCTGGGCAA TAAGAGCGAT GCTCCGTCTC AAAAAAAAAA AAAAAAAAAA AAGAACTTAT ATTTrCAGAT TGTGTGGTTrC CTTTACTAAC TGAATTTAAA TTATTTGTAG TCAATTTTAA ATGCTCTTGT ATT-rTAAAGC CACTGTACTC CAGCCTGGGT GACAGAGTGA AACCCTTAAT TCAAAAAAAA AAAAAAAAAA AAGAAAAGCT GGAATATTGG CAAAATCAAG TAACTAAGAG AAAACATTAA ATTCACAGAA TACATTATTA CATTTTAGAT ATATATGGTA TATG117TTCT CTGAAAAGCA CAAGCATACC 1TFTTGTT ACATTATTTG TAATTAATCT TTrCTTFGTACT CATAGTCACT AAAAAGATTC AACTGTTACA TCTTrAGCTA CATTGTATI7G AGATCCAAGT ATTAAGATCT TATACCCTTA ATTCAGGAAG TGAATAGGCG ATTCAGTGCA TCAAGACAGT CAAATTTATT GTGAT[TT AAAAAAATTG GGGGCTrTTG GGGGGAYI7AT TYFAAGCTAGA TGATAGCCTG AGTTTTGTCT TGTCTFUTCT GAAATTATTC GATGACATGA ATCCAGACCA CTCTAAGGAA TAAAGAATGT CAAAATTTTT ATTAAAYITTA TAGAATTAAA

CTTATTGAAA

TGATGATTCT

TAGATGAAAA

TTGACTGTGT

AGGGTGGCTA

GTTAGCTTGA

AATTCCTTCC

GTGCGAAAGT

ATGCTATTAA

GTTGTAAAAA

TGGATGTTrAC

AGTGATTTCT

TGTATGAATT

TATTTTACAA

ATACTGATAC

GACGTGAATA

TAAATGGAGG GAACTAAAGA TACTT-rGGTG CCAAAATGAA TGGGTTTCTA ACTYITAGCTT TGAATCGTAA TCMTCAAAT CTATCTGAAA TATCTTAG AA'TTTGTTCT TOACCACCAG TGGATGTTGA GTGTTAACAG GCCTATGGGA AACAGTATTT TGCTATTCTT ATAATGTTTA GGTCATTTAA ATTlGTTAGAA ACTTTTCACA GACAAAAAGC TTGTGTAA GGTCATTTAC ATTGGGTCAA AAGGAAACTG GTTAGAAAAT AAGTGAGTAG AGAAAATACC C17GTAAATG ACTGTATGAA TGTGGATTCT AATACTTA T1TMTGCAT CTCTAAAACA TGAACTTTGA ATAGATTCAA ACCATAGAAA TGGAAAATAA ATTJTCTGTTT TACCTMTCT CTGTATTG TGCTTAATTA GGTACAATTG TAGTGCAAAA TCAAATTATC GTATTGTGTF 'FCTCTGTAA CTTATTCCTG TTTATTACTT GATTTGTTTT TACAGACTGT AACCAGTCAA GCCAGAGGAC TGTCAAGCCA AAATTTGGAA GTAAGTCAAA TGTATTAGAA AGCAGGAGAG AGAGGGAGCT TGATTAGCTA TGTATTCTTA TGTAATGGCC TAATGTTGGA TAGAAACATG AATTCTGAAT AATAAACTCT TATAAGAAGA AT]TCAAGG ATATGTGTGG AACACCTGCC ATGTGTTTTG CAGTTGUTCC AGTATTTGTA GTTCTGATAG ACTAAAGTTC CAYITGCTGTA TTTGTAGCAC CCAGCATGCT GACTAATACC GAAATTTCCT TCCTTATTCA CAGACAATGG TGCAGCTCTT CTGTGCCACA CAGGAATCCA TCATTTTGGA AAATATTCAG AAAAGCACAT TTGTGCATTG TAAGGTGAGT AAAGGTCTAA CATAGGGGCT GAGTAAAATA ATGTTTGTAT AAGATTTTAC

GAAGTCATCA

AAGTTTGTGT

TGTGAAAAGA

TTTTCAGTGC

AGGAGCTCTC

AGTCTCCCCT

TTATACTTTG

ATTITTAGTCT

AAAAAGTGGT

TATAAAGAAA

GCATTGACCA

TrfATTTJAGTC

CAGACAGTTT

ATAGGATGCT

GGAAGTCAGA

AAACAATGAA

C11TGAGCTTT GGGTGT17AC

TAATGGAACT

AATAGGTGAG

TCTAATGATT

TAATCTTGAA

GTAATTTCTC

ACTTTCACAT

TACGTGCATA

GTGATGCACT

CAGGCTGGAG

CCTCAGCCTC

AGCTAGCTGA CCCTACCTGT TAGTATTCTA AATGGCTAGA GGAAGAGACT GTGTTTTGTT ACAAAAAATA TATTCTAAGT ACAGGATGTG YI7CAGCATAT CCTCAGTCCT TCATATAATT AATGGTATAT AATCAATGTG ATATTATTGA AATAAACTr TCCATAGAAT AAAGAACATG TTTAAGGAAG TCATTAAAAG TGGCTTTG GGGTTTTTTA

GAAGTTTTAA

ATATTCAATT

CATCTCTACA

TAATATTGCT

AAAAATGTCA

AATAATATTTr

TGAATATGTG

GATTTGTTTT

ACCTAGT'TTC

GCTGGACATG

TGAAGAAAAC

CATGTTATTT

AUrTGGAATT

CACAATGATT

TTTfrTTAACC

TGTGTATGTA

TTATACTAGT

TGCAGTGGCA

ATGAGTAGCT

GAATTTGTGT

ACCATTATGA

TGCCAGAGGT

A1TTTGTTGGG

CGCACCTGGC

TGAGACAGAC

TTAGATGTCA

A.GCCTTGAGG

CGAATGAAAA

CTAATGTTAC

ACAGGGATCC

GAACT1TCCTT

CACAAAAGCT

TCACTAGTTA

CCYITr~AG

TAAGTAAATA

GTTTTATCTT

TGAAATAGTT

TTATAAAGGA

TGCCTAGAAT

ATTAATACCT

TTCTGTAT1T TATACATGCT TGCATCTCTT GAAGCACACT ATATTTAATG ATTCAGTAAA ITTTATGATCT CTAATAGTAT GAATTAAAGT TTCTCTCATT TTTATTTATC CGTAATCAGA ATAGTGAATC AGACCTTCTC CAGGCTCTrT TCAAGGAGGC CTATITCTCTT GTTTGCATGG ACCCTTTAGT AGATGACAAT GATGATATrT TrCTGCTTA GTATATGGTG ACTATAAATC ATGTATCAAT TCTTACTAAT TATGCATTAA AATTGATTTA AATCTTACCA TGTAAAATTT ATTTGGGTA CCTTAACCTA GATTTrGCGTA AACTTATATA ACTTTATAAT CTCTGAGGTT GTCCATATTC ATAACTGATA TrGAGATGCA GTTTATATTT CCTTCCAGAA AATATGTCTA TTCTCATATA CATATTATAA TGAAATAACT TTAlTITAT TTTATMTAT TTTTfGAGA CAGAGTCTCA CAATCTCGGC TCACTGCAAC CTCGCCTCCC GGACTCAAGC GOGATTATAG GCGTCCGCCA CCACACCTGG CTAATTTTTG TTGGCCAGGC TGGTCTTGAA CTCCTGACCT CAGGTAATCC TACAGGCATG AGCCACCGTG CCCAGCCAAT ACTAGT1TAT CATTGATTTT ATCACTCATT AATGGATTAT GAACAAGAGT TTCAAAACTT TGGTATAAAG AGAGTAAGTT GGTTTTGTGC CACCACCTCA AAATCTATTT ATTCACTATT TA1TTA117CA

ATTGTTGCAA

ATTTCCCCTC

ATGTCATGTT

AAGTTAATCC

TTATGGGTCA

CTCT'rTGCTG

GCAAGATCAT

GATGTI7CACT AAA1T-GGCT TGTGTATrfCT

CAAAAGCAGT

TGAATATGGT

TAAAATYrGTC

AATAAATTT

TrAGTTrACT

AGAGACAATA

TACATATAAA

CATTTTACAT

AGAGACAGGG TTTCACCGTG GCCTCCCAAA GTGCTGGGAT T-rGCTGGTCG TAACACACTr ATATAAAGGC AAAG'TTrGCA GCACCTGT-rG CTCTGCAACA AGTCTGCAGT TTAGGGTGGG GTGACTTCAG TGACTrCATT CATCCAGCAG GTTCACCCTA TGTGAGCAGG TCGCTGTGTG GCCACAGCAG GTCATAGCGT GTGGCCATrrr ITATAAATAA TGAATTCTTC CTTTTAGAT TAGAATATT CAGTITATAAT TGGTAGGTAT AAACTTCAGA AG1TTAAATA ATTCTMTGA AATTGTrCAG TAGATAGTTT

CTGTGTAGCC

GAT-rCTCCTG

TATTTTTAGT

ACCTGCCTCA

TTTTAAAGAA

TTGAAAAACA

AGTGTATCAG

TGATTCTGTG

ATGTCCTGAG ACAACTTTCT CACATCTGGC TGT7GGCAGA TCTCAGATAC CTGATGCCAG CTAGCACTTT TCAAGTCT TTAGCCCAGA GTCATTGTAG TCTACCACAG ACTGAGTAAA 1T'CTTTCCT TAGCAATTTG AGGGTACAAC T1TTATTCCA AGTTAATAT CAATATTrAT CACAACTGTT TCCAAGITGT TAATTATAGG AGAAACTCAC 218 CTGATCCACC TGGGGCACTA GCTCACCCAT GGCAGAAGTA CTTGAGAAAG CCATGTGCAT TGG1TTCAGG GTT-TCTAAGA GTAGCAAAAG GCTTGCCT7A AlTTATrAT TGTCCCCCGG AAAAGTGTGG ATTCACAAAG GGCAGTCATT AGCC1TGCAT GAATACCATG GATAY17AAT1 TTTTGTCATT TTGGATTAGA A1TATATCTG CTGAACATCT TTAGTTrTAT TI7AGGTCATC AAAAACCATT AACAAGTGTG ACACTTAAAT GITACGTATT TTAATTCAAT CCCCATGACA TGGATGTC

CAAATGTTGA

TTAAAAGTTC

TGTTATCTTT CTTfGCAGTT ATYITCATGCC AATACTTGGA TTCCATAT TCCCCAATCT AATGTTCACT GACACTGCTG TACCCTGT GGCCTCTAAA CATGGGCCAG ACTAGAACTr TTCTAGGA17 AGATAAATTG TGTFCACACT TAATTCCATT GGGATAGTGC CTGTAGCATT TAAGAATATC TACTTTATAC A-FlCATTFCTT

AGTTTATAAT

TAA'FrATTCA

TCTGATAATC

ATTAAAAAAA

AACCACT-TT

ATAACTATAA

TGTACAGTAA

CATCAGATTC

ACATACATAA

TCTTGTACTA CCAGGACATT GCTTAAATCC ATTCTTGAAA 717AGTTTGCT CATCTGAAAA CATCACTGTG AAATGCTTAG CATCATCACT GATTATCTTC AAAAGTAAAT CAGATCATGT CCTCTGTGGA TGCTGCCTCC ACCAAACTCT CCTGTCCCAG TGTGTACCTT GCTAACTCCT 'FrCTTTGATA TCCTTACCCT CTCTCTATTG TAGCACCTTA TTTAACATTC TCTCTCATGC ACCCCMTGT CTCCAGGGCC GAAAAAATTA GCAACTTATT TATGTGATAT ATGATGCTf7 AGTTACTTGA TGTGTTACTT CCAGTCCATA ATAAAAAGCC TCCTTCCATT CTTGTTTACA TAGCAT'rrTA AACAGCAACT TAT-rTAAGAG GATTAATT AA11TACTTT CACCCAGAGC CCCTCTTTGC TTGGTAACTG ACAAAAATTC 'FITTGT-rCAT CCAACGCATT GCGACCTTTA TF1GATATAGT CATACATG ATTATATTCT AAAAATTTGT TAGTACCYI'T TGCTrCAGA AGTACTCAGG ACCTAACAGT CCAAGCTGGA GTGCAGTGGT TGCCTTAGCC TCCTGAGTAG ACGGGGTITC GCCATGTTGG CCCAAAGTGC TGGGATTACA GAATTGAATA TFITCTTCC117 GGAATTCCTT TGTACCTGCG GTCCTAAAAC TGGTAGCAAC TITAAAAAGA AGTTCTGAAG T-rCUGCT-rC TCTrCT-rTAT U-GTCCTCAC 'FrCA'rrCGTG

AAGTTGCCAT

TCATTTACTC

TGGAAATAAT

AAATGTGCAT

CACTCTTACC

TACTCTATTG

TTCACCAGCC

AGTCTTTTCG

GCTJTACTGTC

AAGATTAAGT

GACTCTGTCA

TAGACCACAA

TGGTAGAATG

TAAACAAATA

TTGATTGTTT

GTGGTGATTG

AGTTGAAACA

GTTAGCTGAG

CTfATTTTCT

TATTTCATTT

ATTGTATTAG

GYFGGTCACA

AflTGTATAA

GGGATACAAG

TTTTJ7ATrTT

AGTACGATTA

CTAGCCCTCA

TATATGTCAT

ATGACCT1TGG

CTGGGATTAT

CCAGGCTGGT

GGTGTGAGCC

GAATAGCAAT

CTCTTCCCTG

TCCTAGGGCA

GTAGTAAGAA

CTCACCTGCC

CATCCTTTCT

TATTGGATAT CTGCTCTGTT ATTTCCAGTA TGGACCATGC TAAGTAAGTT TG1TrGTTAT 1TTTTACTTT TTAGAAAATG TGATTCTA GATTGCATTT AAAACA1TI GTGTGAAfTT CAGATATTCT ACATGTAGCT CTCAAGCCAA ATTGGACTTC ATGTTCTTCC TAGTAGCTA GTACTTCAGA AATAATGGGC CTITCTGCTAC TGTTGjTTTAA CCAGCTATCA AGTATCCTAT TTAAAACTGA ATATAATCTT TlCATTAGGT ACTF17AAGT TTTTAAC1TT CTGAAACTGA AGCATTTTAA AGGGTCACCA TTAGGGGTGA GAGGAGATGT GGTTGAGATG TAAAAATGGT AACATTAAAG GTCAGTGTAT TTTCAGGTCT TAGGTACTTT TCAGTGG1TA AGAGTGTTGC CTGGGAGCTG TATCACATGT CTTCTGAGCC CTTGGGCTAT TTGGTTAATT TCTCTGAACG AATAGCAACT TCTTGACAGG GTTATAGTGA GAAYFrGAGTT GACACATAGT TAATACTCAA GGAATTAGCC ACATCACTAT CTCTTCCAGT TCATITrCTG CCCAGCAGAA TGATCTITITA CTTGAAGTCT ATCCCA17TG ATTAAGAATA ACAACCTAAT TGTCTCATGC TGCTCTCCCT ACTCTTAGTT CCTCAAACAT TGGTITI'TCC ATCTGCCTAG GATGCTJ7CTC TCTCCTATTT T11TCAGTTCT CAGCTTAAGA GTTATATCTr CATGATAACA TAGATTGATA TCCTTACCCT AAGAATAAGT TAGATTAGGT TTTrGACAAAT CACAGCCCTA ATrAATTATr CTTAAAATTA GTTTCATGCA GGTAAGGCGG AGATTGTGTC CATTTGTTTG CCTCATACAT AGTAAGAATr CAATTAATAT iTTACACAGA TAACTGCTTC AGAGGTAAAC TGGGCACATC TTAGTI7ATAT TTTTAAATGT TCTACAAGGT AGATATITGTT AGAGGTCCTA TA'TC1TTC TTTTTAT[CA TTTAGGCAGA GCCTTAAGCA CAAAGATATA ATI'ACTAGCT TGTGTGAAGA CATTCTTT[C CAGATGACAC AGTCAGATGC ACAGGTAAAA TTTGGGCTAA TTGGCAG1TA GTAAATCTCA TrrGAATGTC TGGGTCAGTC GGGTGTI'TTT TTTTGATCTG TGGGATTATT TATATCCCAT ATrCCTAACT GCTGTCATTG CCTCTGGGGT CTGCCTGGCT GCATTCTTCT CAGAATCCTT TCATTCTTTF CTGCATGAGA GATCTGATAT AGCTGCAATC AATCTFUGCAT 1TTT-CTFJCA TATGTITrGTG CATGTATATG TATGTATCAG TCTTTTAAAT GAAAAGTTAG AGTGT-TGAAT TGGTATCCCA TTTATGAAAC TTGGGAATTA TAACTCATTT TCCTGTAACA CTGTTATACA ATTMTI'A ACTATAGTAG TCCTAAATTA TAAGATI7AAT TTGT1TTTTT TTTTTTGAG ATGGCGTCTC ACTCTGTCAC CTCACTGjCAG CCTCTGCCTC ACGGGTTCAA GGGATCGTTC AGGCGCCTGC CACCACGCCT GGCTAATTTT TTTAGTAGAG CTCGAACTCC TGACCTCAGG TGGTCCACCC GCCTTGGCCT ACCGCGCCCA GCCTATATGT AATAATTTfA ATGGGACCAT GACATAGCCC CTTCTATrGT ACATCTGCAA GCTGATACAG CCAGTCAGCT ATGGGGGTGA AAGTGTAGGG GTTCATCCAA GGGCTGATCT GGAAGGACAG ACCCTAGGGG AGGGTGGAAC GGAAATGAGG AGTAGTGTI'A GGAAGGGGCT AACTTTTrC CCTCCCCFUG TATCCCTTCT TCCTTITCC CTTTCCTT[ GATTCCTCTT ACCT-rGCTAA AAGGAGAAGT TI7GT1'TGGGT CTTC1TACC T-rTATCCTAT AGATTCATAT TCTCAACACC rTCTCTrGAC ACCACAGAGT TUGCAGCTAG TACTTGGAGA AGTAAGATGA AGAAAGTCTA AACAACAGTA TAGTCTATAG

ATCCTATATC

AAccTCCTCC

GGAAAATTAA

TGGCAAGAGA

ACTGCTJ7ATA TITrGGGACTG

TATAATTTCT

17ACCAATCA

CTATAACAAA

GCTGGGAAGC

TGGCCCCTTG

GCACTTATGT

AGTATCACAT

AGTCAAAATA

GTATITAATTJ7

CTCTCACATT

AGAATATATT

GTGTCTTCAC

CCTCATCTTA

TTAGAACTTA

CAATTAAGTC

ATAGTTCYFJ

TCTGTCGCCC

'rrCACGCCAT AATGGCAGGA AGGTTGYr T=T7CAGTT TCCTTCTTGC ACAGAGATAC TTGGACCAAG GAGTATGGGG GCTGCTTAGC CAGGGTGjGCT GTACATAAAG TATATCTTCA GTTTATATAA GATGGAAATC AGAAAATTA AATTCTCTTA ATAAATGTGA CCAGTTCTGC TITACTGTCCA TCAATCTTAA CTCCAAATTC TGATCAGCGA AAGTAAAGTA TTGAAGTTTT CCTGGCAGTI ATCCC'ITAAA CTGGGTAAGG GATTATAAAT CCAATATCAA GGCACCAGTA GATTTGGTGT TTGCTGCATC CTCACT7AGT GCAAGGGGCA CATTCATGAG GGCAGAGCCC TCATGACTIA TGGGTGTTAG GTGTCTGGGA GGACACCAAT ACTGTCCAAG AAAATTCTCA TT=fCAAA TTGCCTGAAA TGGAGCUTTG AGGTGGACTG CGCCCTCTGC TG~rCACTAT TAATAMTAT *TTCACTTTGT G'ITTTAGTCC ATTITAGGCTG *A117AGAAATF[ TATCTCTCAC AGITTCTGGAA CTAACGAGGG TGTGCCGTCT GCTTCAAAAA AGACAGCTCC C'rrCAACCTC 1TIATAAGG ATCACTTCCC CAAAGGCCCC ACCTCTITAAT CTI7CAAGCCA TATCATCTCA CTITGGAAAAA AAACCAGTAG ATTTAATTM CCTGGGGTTG CCGTAACAAG TCTAGAGGCA GAAGTTCACA TCATATCYIFT CTCTTAGC'T ATCATCTTr TATAAGAACA ACTAATTATG TCTTCAATAA AAGCTTfG GGAGGGACAC TTGAAATTGG T-17CAAAAAG AGCCCCCAAT TTTTITf AGGCCGGACT GCGGACTGCA TCCCCTGCCT CAGCCTCCCG TATTACACTA YTTATAGAAG CATGTGATGT ATCATITCCTT TTACCACAAA CTAGGTGGCT TAAAACAATA GAATTTT GTGTGTCAAT AGGGCCATGT TCTCTGGAAG GCTTTAGGGG CTCGGTGTCA CTGGCAATCC TTAGCTTACT T-rGGCTTTCT CCAGTGATAG TGATTAAGGG CATACCT7AC TTfAATATGA CCCTATfCC AAATAAGGCC ACATTCTGAA GTATI'GGGAG AGTTCAACCC ATAACAACCC CTAAAATCGA TATITATTCT AGAATATTCT ATfAGAG'TT Y[AATGTATA GTTfAACAT 1TTTT1TIT YTTTMTTT TTTTGAGAC GGAGTCTCGC GTGGCGCAAT CTCGGCTCAC TGCAAGCTCC GCT7fCCCGGG AGTAGCTGGG ACTACAGGCG CCTGCCACCG CGCCCGGCTA TTCACCITGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC CTGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTGCCCC 219 ATTTTGT A1TITAGTA GAGACGGGGT ATGATCCACC CGCCTCGGCC TCCCAAAGTG CAATTATTTA GTTTrTCTAT AAACAGGGAA ATTTATfGT GTGGCCCTTA GAACTAATfT AATTTCCACT CTAATTCCTA CU7ATGTTTA TATAATGCTT TTAGAAATTT GTATTATTCA GAAAATAAAC ATATACTATT GTATCTGTTG CCTACACTTA GATT'rrA'rrG CCTGCTATAT TTAAATTTTA TTAGTATITT AATTGTTTTA TTAAAGAAAG AATGTGCCTG TAATCTCAGC ACYTrTGAGA GGCCAAGGCA GAAGGATTGC TrGAGCCCAG GAGTTTGAGA CCAGACTGAG CAACACAGGG AGACCCCCAT CTCTACAAAA AATAAAAAAA TTCTCCAGGC CTCATGGCAC ATACCTGTAG T"TCTAGT-rAC TTGGGAGACT GGGGTGGGAG GATGCATfGA GCCCAGGAGA TITGAGGCTGC AGTGAGCCAT GATCAGGCCA CTGTACTCCA GCU-GGACAA CAGAGTGAGA GCTTGTCTAG ATAGATAGAT AGATAGATAA TCTAAATAGA TAATAGACAG ATrATCTAAA TAGATAATAG ACAGATTATC TAAATAGATA ATAGACAGAT TATCTAAATA GATAATAGAC AGATTATCTA AATAGATAAT AGACAGATTA TCTAAATAGA TAATAGACAG ATTATCTATC TAAATAGATA ATAGATTATC TAAATAGATA ATAGATAGAT AGATTAGATA GATAGATAGA TAGATAGAGC TTGGACAACA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AAAGAAAGAA AGAAAGAATG GTGCTCATAT TTTAAAGCAT TGAAAAATGG TCTTrCCTTGC TTATATTACC CACACCTTCT TTGTTGGCAT TAAGATGCAA ACYrTGTT~ AAACAGTTGA GTAAATCAAA GATGGGACTG TTAAGTTATT TGTGTTATTT ACCTGCT1T TGAAAATGTA AAAATAAAAC TCTAGGTTrTA ATTAGTAGTA TGCTATU-AG TAATGAAGTA AAGCTAGAGG CTTCGAACAA ATCTTGTGTA ATTTCCTCTT GAATGAGAGA GAAAATTI7AA AGTAAGCAAA CAAATAAGTT GTGTGTCACC ACTCATTCAG TCATTTAACA AGTAMrCCA GAGTACTTAT TCTGTGCCAG GAAATGTTGT AGGTGCCCTC AACAACTTAG AGTCTAGCCT GAGACACAAG TAAGTAGGTA AUTAUATAG AATGGTATGA TCTTTGGAGG ACTGGGTATT GGCTGGCTCA TGGGAGTACA AGATAGGTAC CCAGTGATGA AGTCAGGAAA GGTTTCTTAT GGTGATATGA TGACGTCTAT OCTGATTATA AGGTCAGTGT AGAATAAACT T7GTGCTTTT AAATTTGCAT AGCACTGTAT TAGAGAGTTC ATCTTCAAAA TAATCGAAAA GGCTGAGTGT GGTGACCCAT GGCTGTAATC CCAGCACTTT GGGAGGCCGA GGTGGGCAGA UTGCTTGAGC TAGGAGTTCG AGACCAGGCT GGCCAACATG GTGAAACCCC GTCTCTACTA AAAATACAAA AATITAGCCAG GAGTGATGGT GCGCACCTGT AATGCCAGCT ACT7GGGAGG CTGAGGCAGG AGGATCACTT GAACCCAGGA GGTGGAGGTT GAAGTAAGCC GAGGTCATGC CACTGCACTC CAGCCTGGGC AACAGAGTGA GACTCCATCT CAAAAAAAAA AAAAATGATC AAAGAAAGGT GAATTTTCAT CTACCCTATT TCTGCTGAGG AAAATGGACT ATTTTCAAAT ATTI'AATA AGGGTCAAAA TGAGGGATC-3' (FRAG.NO:J)(SEQ.ID NO:2480) AGGCAGCAGT GATACCCACC TGAGAGATCC TGTGTTTGAA CAACTGCTTC CCAAAACGGA

AAGTATTTCA

GCTCTCACTT

cTTATGATGA

GATTGAGTAC

AATGTGTGGG

CCAACAATAG

GAATGATGAG

AGTGGCCACG

TCAAGTGTGA

CCCACTGGGA

ATGGAGACCA

GTGATGCTGT

CACAACCTGT

TCTGGGAATTr

ATGGCTCTGT

TGAGGAAGGC

ATCCCAGTTT

CTAGTGCTTC

GGGATCCAAA

AGATGCGATG

CCTACAAGTC

CACATCTCAG

CCGOGAAAGA

AAGGATGGAC

TACCTGTGAA

CTGACATTAG

GCAGCTGCCA

TCAGAAACAG

GTCTCTGGCC

AATAGATCAA

AGGATCAAGA

CTCTGAAATC

ATTTTGTGGC

ATGAATAATA

ATGTTrGAATG

AGGGTTACTA

ATTGTGATAT

AGGGACTTAA

TCATTGTI'TA

AGCAAGGCAT

AGAATTGGAG

CCACGATGAA

AGCCTAAACC 1TTGGGTGAA AAGAACTCTT GAAGTCATGA TTGCTTCACA GTrTCTCTCA TGGTGCTTCT CATTAAAGAG AGTGGAGCCT GGTCTTACAA CACCTCCACG GAAGCTATGA GGCCAGTGCT TATTGTCAGC AAAGGTACAC ACACCTGGTT GCAATTCAAA ACAAAGAAGA CTAAACTCCA TATTGAGCTA TTCACCAAGT TATTACTGGA TTGGAATCAG AAAAGTCAAC TCTGGGTAGG AACCCAGAAA CCTCTGACAG AAGAAGCCAA GAACTGGGCT CCAGGTGAAC GCAAAAAGAT GAGGACTGCG TGGAGATCTA CATCAAGAGA GAAAAAGATG TGGGCATGTG AGGTGCAGCA AGAAGAAGCT TGCCCTATGC TACACAGCTG CCTGTACCAA TACATCCTGC

GTGAATGTGT

GCAAATTGTG

AACTTCAGCT

TGCAGTGTAT

GACAAATCCA

ACATTTGACT

G3GGACAACGA

GAGGTGCAGC

TrCATG'FGC

GTGAAGCTTT

TGGCAGTT7C

AGGCTCCAAT

CTGTCCACCA

CTCTTGTGCC

GGACAATGGA

TCAACATGAG

GCTCAATGGC

GCTCCCACTG

AGAGACCATC AATAATTACA AACTGTACAG CCCTGGAATC ACAATTCTTC CTGCTCTATC GTCCTCTGGA GAATGGAGTC GCCAATGGGT TCGTGGAATG GTGAAGAAGG ATTTGAACTA GAAGCCAACG TGTAAAGCTG CATTCCCCTG CTGGAGAGTT AGGGACCAGC CCAGGTTGAA CCAGTGCACA GCCTTGTCCA CGTTATGGGT CCAOCTGTGA GTGGCCCCAC AGGGGAGTGG GCCCCCGAAG GGTTTGGTGA TTrCAGCTGTG AGGAGGGATT CAGAAGAGGT TCCTTCCTGC CTGCAGTGGG GAGCCCGTGI TCTGCAGCTC GGACATGTGG AGTCCAACAT TCCCTF7GGTA CTTGCAAGTG TGACCCTGGC TI'CAGTGGAC CCCTGAGCAT GGAAGCCTGG TTTGCAGTCA AGCTGTGATA GGGGTTACCT GCCAAGCAGC CTCCTATTCC AGCCTGCAAT GTGGTTGAGT TTTCCAAAAC CCTGGAAGCT TCCCATGGAA ATGGGAGCCC AGAGCCTTCA GTGTACCTCA TGACATGCAG GGCCGTCCGC CAGCCTCAGA CACCTTCAAA TCATCCTGCA ACTTCACCTG TGCACCACTC AAGGGCAGTG GACACAGCAA ACCCCGAGCG AGGCTACATG AATTGTCTTC GTTCTCCTGT GAGCAGGOTT TTGTGYJTGAA GACAACGAGA AGCCCACATG TGAAGCTGTG GGTGTGCTCA YJ7CCCCTATT GGAGAATTCA TGAA'ITATAT GGATCAACTC AACTTGAGTG CAAGTGGTAA AATGTTCAAG CCTGGCAGT rTTGGCACTGT GTGCAAGTTC GCCTGTCCTG AGCCACAGGA CACTGGTCTG GCCTGCTACC GCTGGACTTr CTGCTGCTGG ACTCTCCCTC TACGGAAAGC AAAGAAATTT GTTCCTGCCA GCCTTCTTAC ATCCTTTAAG TTCAAAAGAA AAGTTAACAG AGACAGATAA CTCTCCTCGG GGCTGAAACC GCAACACCCA TCACCACTTC CACCATTTCT CCTCTGGCTT CGGAAATGCT AAGCCTTGAA TCAGACGGAA GCTACCAAAA GTGCATCTGG GGAACTAGAG GGATACACTG CTrCTTGCCT ACTATGCCAG ATGCC1TAT AGTCCAGCAG GCAAGGACGG CCTTCAACTG AAAAGACTCA GTG'rrCCC~r TCCTACTCTC AAGTGTTGGC TAATGAAGGG AAAGGATATT TTCTTCCAAG CAAAGGTGAA GAGACCAAGA TCAGAATTCC 'm-CTAACT CTCCCfTGCT CGCTGTAAAA TC'rrGGCACA GAAACACAAT TTTCTTT TTGCCCTTCA CAGTGTTTCG ACAGCTGATT ACACAGTTGC TGTCATAAGA ATTATCCAGA GTTTAGAGGA AAAAAATGAC CCCACAGGCA AATGCATGGA GGGTTGTTAA TGCACAATTT AATCACTTTC ATCCCTATGG T1TrACTTGC ATTGAATATA TTATAATCTT AAAACTTGTA AATGCTGTCA ACTATGATAT Th7AACAAATT ATGTI1ACATC TGTTTrAAAT GATGTTAACC AGAATAAAGT TCTGAGTGT[r AGTAAAAACT GAATGGAAGG TTTGTATATT TAAAAATATT ATAACTTAAA AAAATGACAG TGGTGCAAAT CCTACTGAAT GCTCTGTGCG GATTCAGTGC 'FfCTTAAAGA GT17CTTAAGG CCATACTrCT TCAT[CAATA CAAGTGTGGT GGTAAAAGT7 ACTTATTCTA GAU7ACCCCC TTATTTCAAA AAGGGAAACT AU-GTCCCCT TTTACTACAG TTGTTTTTTG AAAACATGGT GTCAGATATT TTTCAGAAA TATGTGGTTT AAACYJ7CCAT GAGGCCAAAC GTTTTGAACT AATAAAAGCA TAAATGCAAA CACACAAAGG TATAAI=TA TGAATGTCTr TGTITGGAAAA GAATACAGAA AGATGGATGT GCYIGCATT CCTACAAAGA 220 TGTTTGTCAO ATOTGATATO TAAACATAAT TCTTGTATAT TATGGAAGAT TTTAAATTCA CAATAGAAAC TCACCATGTA AAAGAGTCAT CTGOTAGAUT T17AACGAAT OAAOATOTCT AATAGTTAUT CCCTATTTGT UTTCU~CTGT ATGUTAGGGT GCTCTGGAAG AGAGGAATGC CTGTGTGAGC AAGCATTTAT GTTTATTTAT AAOCAGATTU AACAAUTCCA AAGGAATCTC CAGTTTTCAG TTGATCACTG GCAATGAAAA ATTCTCAGTC AGTAATTGCC AAAGCTGCTC TAOCCTTGAG GAGTGTGAGA ATCAAAACTC TCCTACACTT CCAUTAACTT AGCATGTGTT GAAAAAAAAA GTTTCAGAGA AGTTCTGOCT GAACACTGGC AACGACAAAG CCAACAGTCA AAACAGAGAT GTGATAAGGA TCAGAACAGC AGAGGTTCTT TTAAAGOOGC AGAAAAACTC TOGGAAATAA GAGAGAACAA CTACTGTGAT CAOGCTATGT ATGGAATACA GTGTTATT CTrGAAATT GTTTAAGTGT TGTAAATATr TATOTAAACT GCATTAGAAA TTAOCTGTGT GAAATACCAG TGTGGTrTGT GTOTAGTTT TATTGAGAAT UTTAAATTAT AACTTrAAAAT ATTTTATAAT TTTTAAAGTA TATATTrTU TAAGCTTATO TCAGACCTAT TTGACATAAC ACTATAAAGG UrGACAATAA ATGTGCTTAT GUT-3'(FRAG.NO:J(SEQ.ID NO:2479) S'-CCT TGC CTG CTO G-3' (FRAG. NO: 1739) (SEQ. ID NO: 1752) OTC CC-30 (FRAG. NO: 1740) (SEQ. ID NO:1753) CUT OGC TTC UTC TGT C-3Dl (FRAG. NO:1080) (SEQ. ID NO:1088) 5'-GOC TGG TGG-30 (FRAG. NO:1083) (SEQ. ID NO:1092) TGG CTT CTC GUI OTC CC-3D (FRAG. NO:1081) (SEQ. ID NO:1089) SD-TOT GGG CU7 CTC GUT GTC CC-3Dl (FRAG. NO:1082) (SEQ. ID NO:1090) UrC GGG OGC TGO TGG-3D (FRAG. NO:1083) (SEQ. ID NO:1091) CGT CCT TOC CTG CTG G-31i (FRAG. NO:1084) (SEQ. ID NO:1093) Human P Selectin Fragments S-UT TCT CUT TCO CUT TCT T COT CTC CTO UTC CTC CU UT TTG CTG TUT TrlT CTC CUT CTT CTC TCC lT CUr UC-3' (FRAG. NO: 1741) (SEQ. ID NO: 1754) U~T CUT TTC-3' (FRAG. NO: 1742) (SEQ. ID NO: 1755)] CUr U-3DU (FRAG. NO: 1743) (SEQ. ID NO: 1756) 5D-TUT TCT CUT TCG CTT TCT UTT CGT CTC CTO TTC CTC CU" U-3D(FRAG.NO:1085)(SEQ. ID NO:1094) CTG UTT TUT CTC CUT CUT CTC TCC UTT CUT UC-3D (FRAG. NO:1086) (SEQ. ID NO:1095) Human Endothelial Monocyte Activating Factor Nucleic Acid Antisense Oligonucleotide Fragments TCT CTT TCG CUT TCT UTT CGT CTC CTG UTC CTC CUF U TTG CTG TUT UT CTC CUT CTT CTC TCC T CUT UC-3' (FRAG. NO: 1744) (SEQ. ID NO: 1757) -CC UT CUT TTC (FRAG. NO: 1745) (SEQ. ID NO: 1758) S'-CTG TTC CTC CUT U-3D (FRAG. NO:1746) (SEQ. ID NO:1759) TCT CUr TCG CTT TCT T7 COT CTC CTG TTC CTC CUT U-3D(FRAG.NO:1087)(SEQ. ID NO:1096) CTG TUT UT CTC CUr CTT CTC TCC UTT CUT UC-3D (FRAG. NO:1088) (SEQ. ID NO:1097) Human 1L3* Nucleic Acid and Antisense Oligonucleotide Fragments TOT CTT GUT CTG GTC CU7 COT GGG GCT CTO TOT CGC GTO G GTG CGG CCG TOG CC GGC GGB CCB 0GB OTT 0GB GCB GGB GCB GGB CGG GCB GOC GOC TCB TGT U7G GBT COG CBG GBG GCB CTC (FRAG. NO: 1747) (SEQ. ID NO: 1760)1 GBG GCB CTC-3' (FRAG. NO: 1748) (SEQ. ID NO: 1761) 5'-GT GGG OCT CTG-30 (FRAG. NO:1749) (SEQ. ID NO:1762) HUMIL3AASI: 5D-CTC TGT CUT GU" CTO GTC CUT CGT 000 OCT CTO-3D (FRAG.NO:1089)(SEQ.ID NO:1098) HUMIL3AAS2: 5D-TGT COC OTG G OTG COG CCG TGG CC-3D (FRAG. NO:1090) (SEQ. ID NO:1099) GGC GOB CCB GOB OTT GOB GCB 0GB GCB 0GB COO GCB GOC GOC TCB TOT UTG OBT COO CBO OBO GCB CTC (FRAG. NO:1091) (SEQ. ID NO:1100) Human 1L3 Receptor Nucleic Acid and Antisense Oligonucleotide Fragments 000 OTO TCC TOO CCT TCO TOO UTC CTC UTC CUr COT UTG CCO TCC OCO 000 0CC CCC 000 CCT GOC TOC OCT CCT 0CC CCO CCT CUT TCC COO OCT CTT OCO CTO 000 GOT OCT CC COT OTO T OCO CCC TC CTC CTO OTC OCO CTT OTC OUT UG 000 CCO OCT UTG CCC 0CC TCC COO COC CTO 0CC COO CC UTC CTO GOC TOC OTO COC OUT CTG UTC UTC UC CTO OCT CTO 000 TOT CCT GOC CUr COT GOT TCC TCT TCC U7C OUT TGC COT CCO COO GOG CCC CCG GOC CT GOC TOC OCT CCT 0CC CCO CCT CU- TCC COO OCT CU- GCO CTO GO GOT OCT CCC OTO TOT UTG COC CCT CCT CCT GOT CGC OCT TOT COT UTT GO O0C COO CUT TOC CCG CCT CCC OOC 0CC TOO CCC GOC CUT CCT 000 CTO COT OCO COT TCT OUT CTT CUT CCT GGC OCA OGA GAC AGO OCA 000 COA TCA OGA OCA GCO TOA 0CC AAA OGA OGA CCA TCO OGA ACO CAO CTC COO AAC OCA OOA CAO AOO TOC C GC BOO BOB CBO O0C BOO GCO BTC BOO BOC BGC OTO BOC CBB BOO BG BCC BTC 000 BBC GCB OCT CCG OBB COC BOO BCB OBO OTO CC-3' (FRAG. NO: 1750) (SEQ. ID NO: 1763) OBO OTO CC-3' (FRAG. NO: 1751) (SEQ. ID NO: 1764) 0CC CCG C-3- (FRAG. NO:1752) (SEQ. ID NO:1765) S'-TCTOOOOTOTCCTO (FRAG. NO:1092) (SEQ. ID NO:1101) (FRAG. NO:1093) (SEQ. ID NO:1102) S'-TCUTCCUTCOTOC (FRAG. NO: 1094) (SEQ. ID NO: 1103) Y-COTCCOCOOOOOCCCCCOGOCCT (FRAG. NO:1095) (SEQ. ID NO:1 105) TOC OCT CCT 0CC CCO C (FRAG. NO:1096) (SEQ. ID NO:1 104) 221 (FRAG. NO:1097) (SEQ. ID NO:1106) (FRAG. NO:1098) (SEQ. ID NO:1107) (FRAG. NO: 1099) (SEQ. ID NO:1108) 5'-GCTTGTCGT-1TTGG (FRAG. NO:1100) (SEQ. ID NO:1109) 5'-GGCCGGCTTTGCCCGCCTCCC (FRAG. NO:1l0l) (SEQ. ID NO:1110) (FRAG. NO:1102) (SEQ. ID NO:1111) (FRAG. NO:1103) (SEQ. ID NO:1112) (FRAG. NO:1104) (SEQ. ID NO:1113) GGB GBC BGG GCB GGG CGB TCB GGB GCB GCG TGB GCC BBB GGB GOB CCB TCG GGB BCG CBG CTC CGGBBC GCB 0GB 5'-CBG BGTGC C (FRAG. NO:1 105) (SEQ. ID NO:1 114) Human IL-4 Nucleic Acid and Antisense Oligonucleotide Fragments TGO TTG OCT TCC U-C GCC GGC BCB TOC TBG CBG GBB GBB CBG BGG GGG BBG CBG TTG GOB GGT GBG BCC CBT TBB TBO GTO TCG B-3' (FRAG. NO: 1753) (SEQ. ID NO: 1766) OGC BCB-3' (FRAG. NO: 1754) (SEQ. ID NO: 1767) 5'-T TCC TTC-3' (FRAG. NO: 1755) (SEQ. ID NO: 1768) TGG UTG OCT TCC UTC-3' (FRAG. NO: 1106) (SEQ. ID NO:1 1115) 5'-GCCGGCBCBTGCTBGCBGGBBGBBCBGBGGGGBBGCBGTTGGGBGGTGBGBCCCBTTBBTBGGTGTCGB-3' (FRAG. NO:1107) (SEQ. ID NO:1116) Human IL4 Receptor Nucleic Acid and Antisense Oligonucleotide Fragment 5'-TCT 0CC CTO TCC 0CC OOC TCT TCG GTG GCT COO CCC CGC TCC '1170 TCT TOC COC GGO UTG OTT CCT 000 CCT GGT TCT TOC 000 COT UTC GOT CTO CTO OCT OGT CTO GOC CCO CGG TOC OOC 000 TOG CUT GCT GTT CTO CCT GGG CTC TCC CCT CTC CTC CUT TTC TCC CT- CCT CTG TCT TOC CTC Cli? CCT CTG GGT CCT CUT OOC CTO OOC OCT CUT CCC CTC 000 COO CTO COG OCO CTC OTO CTG CCT GOT CCO CTC CCT GGO OGT GCT CCT TCC CUT TCC CCG CTC OTO 000 '111 OCO 000 CTO GGC TGC CCT GOG OGG TCT GG CCT UTT 000 GTC GOC TGG CTG CTG CU- COO 0CC 0CC TOO OCT TCC CTG TGC CCC '111 CCT CTG CTG GOT CCC CCT CCC OUT CCA AGC TOC ACC OCA CAO ACC GOC OCT ACA GOA CAO AGC CAG OCA AOC ACC CAT GOG OAT CCA OOC CCA GCT OUT CCB BOC TOC BCC GCB CBO BCC OOC OCT BCB GOB CBO BOC CBO GCB BOC BCC CDT 000 OBT CCB OOC CCB OCT 0 -3'(FRAG. NO: 1756)(SEQ ID NO:1769) 5'-TCTOCOC-3- (FRAG. NO: 1757) (SEQ ID NO: 1770) 5'-CCT OCT CCT 0000 (FRAG. NO:1 758) (SEQ. ID NO:1771) (FRAG. NO:1108) (SEQ. ID NO:1117) (FRAG. NO:1 109) (SEQ. ID NO:1 118) ('FRAG. NO:1110) (SEQ. ID NO:1119) (FRAG. NO:1I111) (SEQ. ID NOA 120) 5'-TGCTCOCTGGGCUTG(FRAG. NO:1112) (SEQ. ID NO:1121) 5'-GUTTCCTGGGGCCCTOOGTTI7C (FRAG. NO: 1113) (SEQ. ID NO: 1122) (FRAG. NOA1114) (SEQ. ID NO:1 123) (FRAG. NO:1 1115) (SEQ. ID NO: 1124) (FRAG. NO:l 116) (SEQ. ID NO: 1125) 5'-OGCGGCTGCOGGCTGOGTTGOO (FRAG. NO: 1117) (SEQ. ID NO: 1126) (FRAG. NO:1118) (SEQ. ID NO:1127) 5'-CCTCCTCCTCCTCCTCOCTCCCTI7U-CTCCTCT (FRAG. NO:1 1119) (SEQ. ID NO: 1128) (FRAG. NOA1120) (SEQ. ID NO: 1129) (FRAG. NO: 1121) (SEQ. ID NO: 1130) 5'-OGTGCCTCCUOOOGCCCTGC (FRAG. NO: 1122) (SEQ. ID NO: 113 1) (FRAG. NO: 1123) (SEQ. ID NO: 1132) (FRAG. NO: 1124) (SEQ. ID NOA1133) (FRAG. NO: 1125) (SEQ. ID NO: 1134) (FRAG. NO: 1126) (SEQ. ID NO: 1135) 5'-OCCTCTCCTOGOOGGGTGGCTCCCTOTCC (FRAG. NO:1127) (SEQ. ID NO:1136) 5'-CC'TI17CCCCCGOCTCC (FRAG. NO: 1128) (SEQ. ID NO:1137) (FRAG. NO: 1129) (SEQ. ID NO: 1138) GOT CTO TOG CCT OCT CCT 0000G (FRAG. NO: 1130) (SEQ. ID NO: 1139) (FRAG. NO:1131) (SEQ. ID NO:1140) 5'-UUT-GGGGGTCTGGCTTO (FRAG. NO:1132) (SEQ. ID NO:1141) (FRAG. NO:1133) (SEQ. ID NO:1142) (FRAG. NO: 1134) (SEQ. ID NOA1143) (FRAG. NO:1135) (SEQ. ID NO:1144) (FRAG. NO:1 136) (SEQ. ID NO:1 145) 5'-OOU-CCCGCCU-CCCT (FRAG. NOA1137) (SEQ. ID NOA 146) CCC AGA OCT TOC CAC CTO CAG CAG GAC CAO GCA OCT CAC AOO OAA CAG GAO CCC AGA OCA AAO CCA CCC CAT TOO GAG ATO CCA AGO CAC CAO OCT 0 (FRAG. NO:1138) (SEQ. ID NO:1147) CCC BOB OCT TOC CBC CTO CBO CBG OBC CBO GCB OCT CDC BOO 0DB CDO OBO CCC BGB GCB BBG CCB CCC CDT TOGGOBBTO CCB BOOCBC CBOOCT 0-3' (FRAG. NO:1139) (SEQ. ID NO:1148) 222 Human IL5* Nucleic Acid and Antisense Oligonucleotide Fragments CCCCCTCG UTCTGCGTUF GCCTU-GGCG 1TTTGTTT GTTU-CTCTC TCCGTCUTTC UTCTCCCCT GTGGGBBTUT CTGTGGGGBT GGCBTBCBCG TBGGCBGCTC CBBGBGCTBG CBBBCTCBBB TGCBGBBGCB TCCTCBTGGC TCTGBBBCGG TGGGAATTTC TGTGGGGBTG GCATACACGT AGGCAGCTCC AAGAGCTAGC AAACTCAAAT GCAGAAGCATC CTCATGGCTC TGAAACG-3' (FRAG. NO: 1759) (SEQ. ID NO: 1772) CCG GG-3' (FRAC. NO: 1760) (SEQ. ID NO: 1773) GGT TTC T-3' (FRAG. NO: 1761) (SEQ. ID NO: 1774) GGG BTG GC-3' (FRAG. NO: 1762) (SEQ. ID NO:1775) 5'-CCB BGB GCT BGC-3' (FRAG. NO: 1763) (SEQ. ID NO: 1776) CTG TU CCC CCCTUT-3D (FRAG. NO:1 140) (SEQ. ID NO:1 149) TTTGCC TTTGGC-3D i(FRAG. NO:1141)(SEQ. ID NO:1150) 5D9-GTT TU TGT TTGT TCT-3D (FRAG. NO:I 142)(SEQ. ID NO:1 151) TCC GTCTCTT CTC C-3D i(FRAG. NO:1143) (SEQ. ID NO:1152) 5Di-CCT CCT GCC TGT GTC CCT GCT CCC C-3D (FRAG. NO:1 144) (SEQ. ID NO:1 153) GGTTUC TGCTT CCT CTC T-3D (FRAG. NO:1 145) (SEQ. ID NO:1 154) 51J-TGT CTC TCT GTC CUU1G TT-31R (FRAG. NOA1146) (SEQ. ID NO:1 155) TGT GCG GCC TGG TGC TGC CCT GCC CCG GO-3D (FRAG. NO:1147) (SEQ. ID NO:1156) GGA AUT TCT GTG GGG BTG GCA TAG ACG TAG GCA GCT CCA AGA OCT AGC AAA CTC AAA TGC AGA AGC ATC CTC ATG GCT CTG AAA CG-3' (FRAG. NO: 1764) (SEQ. ID NO: 1777) GGB BTT TCT GTG GGG BTG GCB TBC BCG TBG GCB GCT CCB BGB GCT BGC BBB CTC BBB TGC BGB BGC BTC CTC BTG GCT CTG BBB CG-3' (FRAG. NO: 1148) (SEQ. ID NO: 1157) Human IL-5 Receptor Nucleic Acid and Antisense Oligonucleotide Fragments CCCAAAAGGA TGAGTAATAC ATGCGCCACO ATGATCATAT CCUTTTTACT ATGAGGCCGT GTCTGTCGTG TCTTTCCU-T GCTCTTGGTG TGTCUTTGCT GTGCCCTGCC TCTCTGCCCG TGTCTGTCGT GTCUTTCCUT TGCTCUTGGT GTGTCTUTGC TGTGCCCTGC CTCTCTGCC CGTGTCTGTC GTGTCTCC UTTGCTCU1G OTGTGTCTTT GCTGTGCCCT GCCTCTCTGC-3' (FRAG. NO: 1765) (SEQ. ID NO: 1778) TGT C-3' (FRAG. NO: 1766) (SEQ. ID NO: 1779) 5'-GCCCTGCC-3- (FRAG. NO: 1767) (SEQ. ID NO: 1780) 5'-CCG TGTCTGTCGTGTCT-3' (FRAG. NO:1149) (SEQ. ID NO:1158) 5'-UCC1rGCTCT-G-3' (FRAG. NO:1150) (SEQ. ID NO:1159) 5'-GTGTGTCTUTGCTGT-3' (FRAG. NO: 1151) (SEQ. ID NO: 1160) 5'-GCCCTGCCTCTCTGC-3' (FRAG. NO:1152) (SEQ. ID NO:116I) CBGTGGCCCC CBBBBGGBTG BGTBBTBCBT GCGCCBCGBT GBTCBTBTCC UUTTBCTBT GBGG (FRAG.

NO: 1768) (SEQ. ID NO: 1781) Human IL-6 Receptor Fragments TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG GCTCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCOC TGCTGGCTGC CCTGCTGGCC GCGCCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CUTGTCTTCC GGCTCTTCTG, CTGGGGTGGG OCTGGGCGGC CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GOGCTCUTCC GGGCTGTCTC CCTCCGGGGC GGGGGTTTCT GGCCGTGGGG GTCUOGCCTG GCCTCCGGGC TCCTGCTTGT CUTGCCTTCC TTCTCTGGTC GOTTGTGGCT CGGGGCTCCG TGGGTCCCTG GCGCCCGTT7 GTGTTTTGTC TUTTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCUTCCT CTGCUTCTCG CTCTCCUTG TGGGGCCCTC CCTG-CTGCTC TTGGTTTFTGG GCUUTTTTC TCUTCCTCCT 1TTTTCGTGCG TGGGCCTCCG CACGCCTCTT GCCACCTCCT GCGCAGGGCA GCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG, CATGCUTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAGGC GCBCGCCTC U-GCCBCCTC CTGCGCBGGG CBGCGCCUTG GGGCCBGCGC CGCTCCCGGC GCGGCCBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTO GTCCCGCBGB GOCGGBCBGG C-3' (FRAG. NO: 1769) (SEQ. ID NO: 1782) 5'-CCCGGCGC-3' (FRAG. NO:1184) (SEQ. ID NO:1193) 5'-GGCCBGCBGG-3- (FRAG. NO:1186) (SEQ. ID NO:1195) 5'-GCBGCCBGCBGCG-3' (FRAG. NO: 1770) (SEQ. ID NO: 1783) GCBGCCGBCGGCC (FRAG. NO: 1771) (SEQ. ID NO: 1784) 5'-GGGOTGGCTTCCTGCC3D- (FRAG. NO:1 153) (SEQ. ID NO:1 162) 5'-GCGTCTCTGGGCCGTCCC-3' (FRAG. NO:1154) (SEQ. ID NO:1163) 5'-GTCCCTCGGCCCCGCGCCGCGCTCGGCTCCTCTCCC-3' (FRAG. NO: 1155) (SEQ. ID NO:1 164) 5'-TCTGGCCCGGCTC-3' (FRAG. NO:1156) (SEQ. ID NO:1165) 5'-GGOGCGGGGCGGGGCGGTGGGCGGGC-3- (FRAG. NO:1157) (SEQ. ID NO:1166) 5'-GGCGCTGCCCTGCGC-3' (FRAG. NO:1158) (SEQ. ID NO:1167) 5'-GCGOCOCTGGCCCC-3' (FRAG. NO:1159) (SEQ. ID NO:1168) 5'-TOCTGOCCGTCGOCTGCGCGCTGCTGGCTOCCCT-3' (FR.AG. NO:1160) (SEQ. ID NO:1169) 5'-GCTGOCCGCGCCGGG-3' (FRAG. NO:1161) (SEQ. ID NO:1170) 5'-GCCTGTCCOCCTCTOCGGG-3' (FRAG. NO:1162) (SEQ.ID NO:1171) 5'-COCTGTCTCCTGOC-3- (FRAG. NO:l 163) (SEQ. ID NO:l 172) 5'-U-GTCUCCGGCTCT-3' (FRAG. NO:1164) (SEQ. ID NO:1173) 223 5'-TCTGCTGGGGTGGG-3' (FRAG. NO:1165) (SEQ. ID NO:1174) 5'-GCTGGGCGGCCGGCCCGGT-3' (FRAG. NO:1 166) (SEQ. ID NO:1 175) 5'-GCTGGGGCTCCTCGGGGGG-3' (FRAG. NO:1167) (SEQ. ID NO:1 176) 5'-GGGGGCTCT-rCCGG-3' (FRAG. NO:1168) (SEQ. ID NO:1177) 5'-GCTGTCTCCCTCCGGG-3' (FRAG. NO:1169) (SEQ. ID NO:1178) 5'-GCGGGGGTTTCTGGCC-3' (FRAG. NO:1170) (SEQ. ID NO:1179) 5'-GTGGGGGTCTTGCC-3' (FRAG. NO:1171) (SEQ. ID NO:1180) 5'-TGGCCTCCGGGCTCC-3' (FRAG. NO:1 172) (SEQ. ID NO:1 181) 5'-TGCTTGTCTTGCCTTCCY1TC-3' (FRAG. NO:1173) (SEQ. ID NO:1182) 5'-TCTGGTCGGTTGTGGCTCG-3' (FRAG. NO:1174) (SEQ. ID NO:1 183) 5'-GGGCTCCGTGGGTCCCTGGC-3' (FRAG. NO:1175) (SEQ. ID NO:1184) 5'-GCCCGTTUGTGTTU7GTC-3' (FRAG. NO:1176) (SEQ. ID NO:1185) 5'-TTCCCCTGGCGT-3' (FRAG. NO:1177) (SEQ. ID NO:1186) 5'-CCCTGTGCCCCTCTCCTCTCCUTCCTCTGCTTCTC-3' (FRAG. NO:1178) (SEQ. ID NO:1 187) 5'-GCTCTCCTrGTGGG-3' (FRAG. NO:1179) (SEQ. ID NO:1188) 5'-GCCCTCCCTGCTGCT-3' (FRAG. NO:1180) (SEQ. ID NO:1189) 5'-CT-FGGTTTTGGGCT-3' (FRAG. NO:1181) (SEQ. ID NO:1190) 5'-1TrrTTCTCTTCCTCCT-FrTC-3' (FRAG. NO:1182) (SEQ. ID NO:1191) 5'-GTGCGTGGGCCTCC-3' (FRAG. NO:1183) (SEQ. ID NO:1192) 5'-GCACGCCTCT TGCCACCTCC TGCGCAGGGC AGCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAGGC-3' (FRAG. NO:1185) (SEQ. ID NOA1194) TGCCBCCTCC TGCGCBGGGC BGCGCCTI'GG GGCCBGCGCC GCTCCCGGCG CGGCCBGCBG GGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG GTCCCGCBGB GGCGGBCBGG C-3- (FRAG. NO:1187) (SEQ. ID NO:1196) Human IL-6 Nucleic Acid and Antisense Oligonucleotide Fragments TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC TGCGCGCGGC GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC GCGCCGGGGC CTGTCCGCCT TGTCTCCTGG cTrGTCTTCC GGCTCTTCTG CTGGGGTGGG GCTGGGCGGC CGGCCCGGTG TCGGGGGGGG GGGCTCTTCC GGGCTGTCTrC CCTCCGGGGC GGGGGTTTCT GGCCGTGGGG GCCTCCGGGC TCCTGCTTGT CU-GCCTTCC TrCTCTGGTC GGTTGTGGCT CGGGGCTCCG GCGCCCGTTr GTGTTTTGTC TTTTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTJ7CCT CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC TTGGT1TTGG GCTTTTTTTC TCTTCCTCCT TGGGCCTCC GCACGCCTCT TGCCACCTCC TGCGCAGGGC AGCGCCTJTGG GGCCAGCGCC

GCTCCTCTCC

GCTGGCCCCT

CTGCGGGCGC

CTGGGGCTCC

GTCTTGCCTG

TGGGTCCCTG

CTGCTTCTCG

TTTTCGTGCG

GCTCCCGGCG

CGGCCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAGGC GCBCGCCTC TTGCCBCCTC CTGCGCBGGG CBGCGCCTI7G GGGCCBGCGC CGCTCCCGGC GCGGCCBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG GTCCCGCBGB GGCGGBCBGG C-3' (FRAG. NO:1772) (SEQ. ID NO:1785) 5'-GGGGCBGG-3' (FRAG. NO:1773) (SEQ. ID NO:1786) CBGGC-3' (FRAG. NO:1774) (SEQ. ID NO:1787) CCCC-3' (FRAG. NO:1775) (SEQ. ID NO:1788) BGBBGGCBBC-3' (FRAG. NO:1776) (SEQ. ID NO:1789) TCT CTT TCG TTCCCG GTG GGC TCG-3DI (FRAG. NO:l188) (SEQ. ID NO:1197) 5D-GTG GCT GTC TGT GTG GGG CGG CT-3D~ (FRAG. NO:1 189) (SEQ. ID NO:1 198) CCT CTT TGC TGC TiTC-3Di (FRAG. NO:1 190) (SEQ. ID NO:1199) TCTTfTG CCT T TCT GC-3Di (FRAG. NO:1191) (SEQ. ID NO:1200) TBCTGGGGCB GGGBBGGCBG CBGGCBBCBC CBGGBGCBGC CCCBGGGBGB BGGCBBCTGG BCCGBBGGCG CTTGTGGBGB BGGBGT-lCBT BGCTGGGCTC CTGGBGGGGB GBTBGBGC-3'(FAG..NO:1777(SEQ.ID NO:1790) Human Monocyte-derived Neutrophil Chemotactic Factor Nucleic Acid and Antisense Oligonucleotide Fragments GGTYFrGGBGT BTGTCTTTBT GCBCTGBCBT CTBBGTTCTTr TBGCBCTCCT TGGCBBBBCT GCBCC'rrCBC BCBGBGCTGC BGBBBTCBGG BBGGCTGCCB BGBGBGCCBC GGCCBGC'rrG GBBGTCBTGT TUBCBCBCBG TGBGBTGGTT CCTTCCGGGC 'FFGTGTGCTC TGCTGTCTCT TGGTTCC17C CGGTGGU-TC YI'CCTGGCTC TTGTCCTTfC TCTTGG CCCT TGGC-3' (FRAG. NO:1778) (SEQ. ID NO: 1791) BTG-3' (FRAG. NO: 1779) (SEQ. ID NO: 1792) CT-3' (FRAG. NO:1780) (SEQ. ID NO:1793) S'-CCG GTG G-3- (FRAG. NO:1781) (SEQ. ID NO: 1794) CCC TITG GC-3' (FRAG. NO:1782) (SEQ. ID NO: 1795) 51i-GCTTGTGTGCTC TGC TGTCTC T-30 (FRAG. NO:1192) (SEQ. ID NO:1201) TTC CT-rTCCG GTG GTrTCT TCC TGG CTC TTG TCC T-3D (FRAG. NO:1193) (SEQ. ID NO:1202) TGG CCC TFG GC-3D (FRAG. NO:1194) (SEQ. ID NO:1203) GGTTTGGBGT BTGTCTTTBT GCBCTGBCBT CTBBGTTCTrT T13GCBCTCCT TGGCBBBBCT GCBCCT-TCBC BCBGBGC-3' (FRAG. NO:1783) (SEQ. ID NO: 1796) Human Neutrophil Elastase (Medullasin) Nucleic Acid and Antisense Oligonucleotide Fragments 224 CGCOBGBGI TBTGGGCTCC CBGGBCCBCC CGBCGCGC OOBCGTTTBC BT!'CGCCBCG CBGTOCOCGG CCGBCBTOBC GBBGT!'GOGC GCBBTCBGGG TGGGCGGGB GBBGTGOCCT CGCGCBGCT GCBOGGBGBC CBTGBBGGGC GBCGCGTGGG GCCGCGCTGG CCOGCCCG BGBBTCTGGG BOGCCBGCGC OGTGCGCCCC BGCI3OCBBGG GGCBOOBG I3CBGGCGBGG BGBCBGCGB GTCGGGGCC GBGGGTGBTG GTGGGGCTGG GGCTCCGGGG TCTCTGCCCG TCCGTGCTGG TGGGGCTGGG GCICCGGGG TGTCTGCGGG TCCGTGCCGC GTGGGGCCGC GCTGGCCGGC CCCCCCCTGC COGTGGCT CGGGCCGCGC GCCGGCGTGC CGGCCGTCG TGGGTCCTGC TGGCCGGGTC CGGGTCCCGG GGGTGGGGCG CGBGTCGGCG GCCGBGGGTC-31 (FRAG. NO:1784) (SEQ. ID NO: 1797) TOG GGC-3- (FRAG. NO:1785) (SEQ. ID NO: 1798) 5'-G GGG GCG (FRAG. NO: 1786) (SEQ. ID NO: 1799) GOC CGG GIG GGG G-3' (FRAG. NO: 1787) (SEQ. ID NO: 1800) TGG GG TGG GGC TCC GOG GIG TCT GCG CCI CCG TGC-3DU (FRAG.NO:1I195)(SEQ.ID NO: 1204) GIGGGGCCG CGTCG CCG GCC CCC C-3D (FRAG. NO:1196) (SEQ. ID NO:1205) GGGGGG TGG OCT CCC 0CC GCG-3D (FRAG. NO:! 197) (SEQ. ID NO:1206) 5D]-CGC COOCCI GCC GGC CCC IC-3D (FRAG. NO:! 198) (SEQ. ID NO:1207) 51D-GIG GGTCCTGOCTGCCGGGCOGGTCCCG000G010GGG-3Di(FRAG.NO:1199)(SEQ.ID NO:1208) 51]-COCGOBGTCGGCOGGCGOBGGTC-3Di (FRAG. NO:1200)(SEQ. ID NO:1209) GCOBOBOOT TBTGGGGTCC CBGOBCCBGC CGBCGCCGGOBCGTTTBC BTITCGCCBG CBGTGCOOG COGBBG OBBOTTGOC GCBBTCBGOO TOGOCCGCB OBBOTOOCCT CGCCBGCT GCBGBGBC CBIOBBOOOC CBCGGGGG GGOGOCIG CCOGCCCCGC BGBBICTCG BGGCC13GCGC GOIOCCCCCC BOCBGBBOG CGGCBOOBG BCBOGCGBGO BGBGBCOCOB OGOGGCGC OBOGGBTO OIOOOGGO GGITCGGGO IGCGCCG ICGGC-3' (FRAG. NO:l 788) (SEQ. ID NO: 1801) Human Neutrophil Oxidase Factor Nucleic Acid and Antisense Olijonucleotide Fragments 5'-CGGGBGIOGG OOIGGIOGBG GGCBCIOBBG GGBICCBOOG CTCCCTTCCB GTCCT!'GTrO IGCIGCCB OCBGCCCTC BT!'CGBGBGO CGBIGOCCI CCBGCBGOOB CBTGBTTBOO TBGBBBGTBG OBOOCGGGC IGCBGGBGOO BGBIGGIGGI TCGTCGG IOGGIGIGIG GT-TTGG ICGGOIO GITITCCTCGI GGGGGIG CIGGOCICTI GT!T[OIII CIGOGCGGT OCIGIGIGTGICCGT!'ICCC T!'GGIOIGIT IGTTIIIGIO GGCGBGGB GGGBGBIG-3- (FRAG. NO:1789) (SEQ. ID NO: 1802) 5-GGOBGIOOG 00-3 '(FRAG.NO:1790) (SEQ. ID NO: 1803) 5'-GGBGGBCCG-3' (FRAG.NO: 1791) (SEQ. ID NO: 1804) CBG GBG-3- (FRAG.NO:1792) (SEQ. ID NO: 1805) GIG GBG GBG GOB GBT 0-3D (FRAG. NO:1201) (SEQ. ID NO:1210) SD-GIG CT!' CII GIG CG 10C C-3D (FRAG. NO:1202) (SEQ. ID NO:1211) SD-IGT CGG 0011 G GIG 00 010-3 (FRAG. NO:1203) (SEQ. ID NO:1212) SDi-OCT T!'G GI G GG 0 GG GIG GIG-31] (FRAG. NO:1204) (SEQ. ID NO:1213) SDi-OG CI CI ITTGT 1TCTGGCCI 001 -3D (FRAG. NO:1205) (SEQ. ID NO:1214) SD]-GIG ICGOICC CTT' CC-3D (FRAG. NO:1206) (SEQ. ID NO:1215) SDi-CT!' 000TOT CII OTT 01-3D (FRAG. NO:1207) (SEQ. ID NO:1216 51D-GGCCGIGCBC CBGGBCBIC0-3Di (FRAG. NO:1208) (SEQ. ID NO:1217) GGICGIGGBG GGCBGTGBBG GGBICCBOOO CTGCCTTGGB GTGCTTCTUrG TCGCTGCGB GGBCCGT!'C BT-rCGBGBGG CIOBIGOCCI GCBGGBGGGB GBIOBITBGG IBGBBBCTBG GBGGCG-3- (FRAG.

NO:1793) (SEQ. ID NO: 1806) Human Cathepsin G Nucleic Acid and Antisense Oligonucleotide Fragments S-CGGICGBGBI CIOCTCIGBC CIGCIGGBCI CGGBICIOB BGBTBCGCGB IGTBOGGGOC GOBOIGGGC CTOCTCTCCC GOCCICCOBI GBICIGCCI GCGTCGCCG CBGIGGTBO OBGBBBGOCC BGCBGBBGGB GOGIOTGGITG CBIGIT[CI GOIGGOGGI GGIGTCCCGG CCICGGGTG TJ7GCTGGGTG T-TITCCOGTG ICGGICGC GnTCGGGT CGI-3Y (FRAG. NO:I1794) (SEQ. ID NO: 1807) S'-GBBOBTBCGCG-3- (FRAG. NO:1795) (SEQ. ID NO: 1808) S'-CBGCCCCBO-3' (FRAG. NO: 1796) (SEQ. lID NO: 1809) S'-ICG GT GIG 100-3' (FRAG. NO:1797) (SEQ. ID NO: 1810) SDi-GIGG000CCITOCTCGIGCCGGCCTICCG0-3D (FRAG. NO:1209) (SEQ. ID NO:1218) SDi-TOT on OCT0GGIn ICCCGOIGIG G-3D (FRAG. NO:1210) (SEQ. ID NO:1219) TICG00G0GGG-3D(FRAG. NO:121 1) (SEQ.tIDNO:1220) S'-CCGIGGBCBT CIOCTCIOBG GTGCTGGBCI CIGOBICTOB BGBTBCGCCB IGTBOGGOCO GOBOIGGOG CTGCIGICGG GOCCICCOBI GBTCICCCC OCGICBOCCG CBGTGGGTBG GBOBBBGOCG BGCBGBBGCB GGBGTGGCIG-3- (FRAG. NO:1798) (SEQ. ID NO: 1811) Human Defensin 1 Nucleic Acid and Antisense Oligonucleotide Fralzments S'-CCGGGOCTOC BGCBBCCTCB TCBGCTCTTG CGTGGBGTGG CICGCGTGG GCGIGCBGGG CCBCCBGGBG BBTGGCBGCB BOOBGCOB GGGTCCTCBT OOCTGGOGTG BCBGBIGGIC TBGCTBGOCB GGTGBGCBG BOBGOC 000 ICC 1GB TOGG GG 0 CG TOG OCC TG BOG 0CC OCT CTT 0CC TOG BOT GOC IC 0CC CBG BOT CTT CCC TOO T OCICAOCGIC CAAAGGAGCC AGCCTCTGCC GAGTTCCIGA AATCGIGAGI GT-rGCCTOCC AGICOCCAIG AGAACTTCCT ACCTTCTGCT GTITACICIC TOCTI-ACTTT IGIGIGAGAT 225 GGCCTCAGGT GGTAACTrTC TCACAGGCCT TGGCCACAGA TCTGATCATT ACAATTGCGT CAGCAGTGGA GGGCAATGTC TCTAFFCTGC CTGCCCGATC MTACCAAAA TTCAAGGCAC CTGTrACAGA GGGAAGGCCA AGTGCTGCAA GTGAGCTGGG AGTGACCAGA AGAAATGACG CAGAAGTGAA ATGAACTTTr TATAAGCATT CTM~AATAA AGGAAAATTG CTTTTGAAGT AT CTGCAGTGGT AAAAAGATTC TATATCTGCT GTTGATGAA TGCAGCACCC ACTAGCCACA TAGTGCTCGT GAGCACYUFGC AATGCGGCTA GGGTGATTTC AATTAACCTA AAAGAGAACA GCCACAGGGA GCATGTGGCT GCCATATTGG ATGGTGCTGC 1TGAGAACA AAATGAGAGA AATGAAGCCT CTATTTACCT TGGTTGGCGG AACACATTGA AGGGACTCTG TATTGATACC AGGCTJTCAAA CTTTGGGAAG TGTACTGGCC AACTTAAACA CATCCACAGG AGAATGAAGA GGUTTGGGAA GGGACCAGAA ACCAGGCATT GAGGACAATG AGAAGAGTTT TFrCAAAAGTG GAATTACTGC AAAAAGTGGA AAAATAGCCT TYrGGATGGAA GTJ7ACTGATG AGACAATTTC CATCGGTGTG AAAGCCATCT T-rCCAACAGA GATCTGCAAC ATGAGAATGT ACTGTCTCCT AGGGTAGCGA TGGCCTCTTG TA11'AGTCCG CTCAGGCTAC CAGAT-rfATC GTTTAAACTG CCCATAAACA GACCAGGCAG TTTAAACAAC AGAAATTTAT TTCCTCGCAG TCCTGGAGGC AGGAAGTCTG CGATCAAGGT GGAAGCAGGG TTGGCTTC17 CTCAGGTGTC TGTCCTTGGC TGGTAGATGA CCGCCGCCTC CCTGGGTCCT CACATGGTCT TTCCTCTGTG TGTGTCTGTC CCAATCTCTT CTflTATAAGGA TGCAAGTCrr ATGGATCAGA GCACACCCCA ATGACCGTGT TTAACTTGAA TCACCTCTTT AAAGTCTC TCTCCAAATA CAATCACCTC CTGAGGCACT GTTAGGGCTT COACACAGGA ATTCTITTCC TAGGGGATTC AGTTCAGTCC AAAACGCCTA CCAGTGGAGA CTTGCAACAT GGCGGCCTGC TGGTCCCTCG CCAGGAATAT CACAGGCGAC TGTTCCCTGT TGCATGGAAT AGAAGGCTAT TCCAGAGTAC TGTCTCTATT TATCAGATCT GGGATACTGG GAGAAGGGCA AAATAAAGTC CAAGTAGAAA AAAAAACTAT GAAAGTITA GAGAGTAACC ATAATTTCAG CCCGATGTGA AACGATCCTA GATTTCAGCT GAAATAGTGA TGTGGGAAGT GAGGGGGCCG GGATTrCAAGG CAGAGGGAAC AGCGTAACTG AAGGCATGGA AGGAGGGAAG TGTAGGCTGT GTGAAGAG TGGCAGCTGC TTCCACATTT CTAAAACACA GGATGTGATT TTGGGGTGTG TTGAGACAAG GCAGAAAACT TGTTTGGAAA AATAACTTGA ATTCCCTGCA CATAAAAT CTCTCAGCAG AAGAAAACCC CACTCAGAAC CCCACTGYUC A'rrCCTTGGC ITGTATTTGG SCACAGCTGG CATAGCCCCA GACTGAGTAA GCTCTTCAGA CACCTCATTT CATGAGTAGC CCCAAAGATC AATCATGGGC CAATTTCT-rG GAAGAGAAGA CTCTCCGGTG FJ7TTGCAGT-r ATTTGTTCTG CITTCGCGAG ATGTTCTCAA ATCGTTGCAG CTACAAGCCA TGAGTCTGAA GTGYITTGTGT TCCCTCC'rrA CAGGTGGTAA CTTrTCTCACA GGCCTTGGCC ACAGATCTGA TCATTACAAT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT TCTGCCTGCC CGATCTTTAC CAAAATI7CAA GGCACCTGTT ACAGAGGGAA GGCCAAGTGC TGCAAGTGAG CTGAGAGTGA CCAGAAGAAA cTT1TrATAA GCATTCTTTT AATAAAGGAA AATTGCTTTFT GAAGTATACC CYTGTGTCTC AATTGGAAGA GGTAAAGAAG TAGGGGGTTA GGGTGCATGG

TGACGCAGAA

TCCTTTGGGC

GTTGGAACGT

GTGAAATGAA

CAAAATGAAT

GAGACAGGTC

GAACCACAAA GCCTGCCTGG AAAAGGGGAG TGACGTCCTA GGCTTCAGTG ATGTCACCTC CACTTfrGTTT GATCCACAAA CCAACAGGTG ACTGAITrTG GTCAGCTCAG CCTCCAAAGG AGCCAGCCTC TCCCCAGTTC CTGAAATCCT GAGTGTTGCC TGCCAGTCGC CATGAGAACT TCCTACCTTC TGCTGTTTAC TCTCTGCTrA cTrTGTCTG AGATGGCCTC AGGTGGTAAC TT-rCTCACAG GCCTrFGGCCA CAGATCTGAT CATTACAATT GCGTCAGCAG TGGAGGGCAA TGTCTCTATT CTGCCTGCCC GATCTTTACC AAAAYJTCAAG GCACCTGTTA CAGAGGGAAG GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT GACGCAGAAG TGAAATGAAC TT' -3 (FRAG.NO:1799) (SEQ. ID NO: 3010) CCTCCAAAGG AGCCAGCCTC TCCCCAGTTC CTGAAATCCT GAGTGTTGCC TGCCAGTCGC CATGAGAACT TCCTACCTTC TGCTGTT7AC TCTCTGCTTA CT'TTTGTCTG AGATGGCCTC AGGTGGTAAC 'TTCTCACAG GCCTTIGGCCA CAGATCTGAT CATITACAATTr GCGTCAGCAG TGGAGGGCAA TGTCTCTATT CTGCCTGCCC GATCTTTACC AAAATI'CAAG GCACCTGT-rA CAGAGGGAAG GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT GACGCAGAAG TGAAATGAAC Tf-3' (FRAG.NO:9) (SEQ. ID NO: 2475) AAAAAGATTrC TATATCTGCT GTTTGATGAA TGCAGCACCC ACTAGCCACA TAGTGCTCGT

GAGCACTTGC

GCCATATTGG

AACACATI7GA

CATCCACAGG

TI7CAAAAGTG

CATCGGTGTG

TGGCCTCTTG

TTTAAACAAC

TTGGCTTCTT

TI7CCTCTGTG

ATGACCGTGT

GTTAGGGCTT

CTI7GCAACAT AATGCGGCTA GGGTGATTTC ATGGTGCTGC TITTGAGAACA AGGGACTCTG TATTGATACC AGAATGAAGA GGTTTrGGGAA

GAATTACTGC

AAAGCCATCT

TATTAGTCCG

AGAAATTI7AT

CTCAGGTGTC

TGTGTCTGTC

TITAACTTGAA

CGACACAGGA

GGCGGCCTGC

AAAAAGTGGA

TTCCAACAGA

CTCAGGCTAC

TTCCTCGCAG

TGTCCTTGGC

CCAATCTCTT

TCACCTCTTT

ATITCTTCC

TGGTCCCTCG

TGTCTCTATT

AATTAACCTA AAAGAGAACA GCCACAGGGA AAATGAGAGA AATGAAGCCT CTATTACCT AGGCTI'CAAA CTTI'GGGAAG TGTACTGGCC GGGACCAGAA ACCAGGCATT GAGGACAATG AAAATAGCCT TTGGATGGAA GTTACTGATG GATCTGCAAC ATGAGAATGT ACTGTCTCCT CAGATTrTATC GTTTAAACTG CCCATAAACA TCCTGGAGGC AGGAAGTCTG CGATCAAGGT TGGTAGATGA CCGCCGCCTC CCTGGGTCCT CTTFATAAGGA TGCAAGTCTT ATGGATCAGA AAAGTITCTC TCTCCAAATA CAATCACCTC TAGGGGATTC AGTI'CAGTCC AAAACGCCTA CCAGGAATAT CACAGGCGAC TGTTCCCTGT TATCAGATCT GGGATACTGG GAGAAGGGCA

GCATGTGGCT

TGGTTGGCGG

AACTTAAACA

AGAAGAGTTT

AGACAATTI'C

AGGGTAGCGA

GACCAGGCAG

GGAAGCAGGG

CACATGGTCT

GCACACCCCA

CTGAGGCACT

CCAGTGGAGA

TGCATGGAAT

AAATAAAGTC AGAAGGCTAT TCCAGAGTAC CAAGTAGAAA AAAAAACTAT GAAAGTTTTA GAGAGTAACC ATAATTTCAG CCCGATGTGA AACGATCCTA GATI'CAGCT GAAATAGTGA TGTGGGAAGT GAGGGGGCCG GGAT-rCAAGG CAGAGGGAAC AGCGTAACTG AAGGCATGGA AGGAGGGAAG TGTAGGCTGT G'TTrGAAGAG TGOCAGCTGC T7ICCACA1TT CTAAAACACA GGATGTGATI' TTGGGGTGTG 'rrGAGACAAG GCAGAAAACT TGTTTGGAAA AATAACTI'GA ATTCCCTGCA CA'TTTAAAAT CTCTCAGCAG AAGAAAACCC CACTCAGAAC CCCACTGTTC ATI7CCTTGGC TTGTA1TTTGG SCACAGCTGG CATAGCCCCA GACTGAGTAA GCTCTI7CAGA CACCTCATTT CATGAGTAGC CCCAAAGATC AATCATGGGC CAATTTCT7G GAAGAGAAGA CTCTCCGGTG TITTGCAGTT AT-rTGTI'CTG CTTITCGCGAG ATGTI7CTCAA ATCGTTGCAG CTACAAGCCA TGAGTCTGAA GTGTTTGTGT TCCCTCCTI'A CAGGTGOTAA C'ITTCTCACA GGCCTI'GGCC ACAGATCTGA TCATTACA-AT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT 226 TCTGCCTOCC CGATCTTI'AC CAAAATTCAA GGCACCTGTT ACAGAGGGAA GGCCAAGTOC TGCAAGTGAG CTGAGAGTGA CCAGAAGAAA TGACGCAGAA GTGAAATGAA CTTFTTTATAA GCATTCTTY[ AATAAAGGAA AATTGCTITT GAAGTATACC TCCYITTGGGC CAAAATGAAT CTTGTGTCTC AATTGGAAGA GGTAAAGAAG TAGGGOGTTA GGGTGCATGG GTTGGAACGT GAGACAGGTC GAACCACAAA GCCTGCCTGG AAAAGGGGAG TGACGTCCTA GGCTTCAGTG ATGTCACCTC CACTTTGTTT GATCCACAAA CCAACAGGTG ACTGATTTTG-3' (FRAG.NO:_9 (SEQ. ID NO: 2474) CAAAGGAGCC AGCCTCTCCC CAGTTCCTGA AATCCTGAGT GY GCCTGCC AGTCGCCATG AGAACTTCCT ACCTrCTGCT GTTTACTCTC TGCYrACTTT TGTCTGAGAT GGCCTCAGGT GGTAACY[TC TCACAGGCCT TGGCCACAGA TCTGATCATT ACAATTGCGT CAGCAGTGGA GGGCAATGTC TCTATTCTGC CTGCCCGATC TTTACCAAAA TTCAAGGCAC CTGTTrACAGA GGGAAGGCCA AGTGCTGCAA GTGAGCTGGG AGTGACCAGA AGAAATGACG CAGAAGTGAA ATGAACT[ TATAAGCATT C1TI7TAATAA AGGAAAA17G CTTGAAGT AT-3- (FRAG.NO:_9 (SEQ. ID NO: 2472) 5'-CCGGGGC-3- (FRAG.NO:1800) (SEQ. ID NO: 1813) GCCTGCBGGG CC-3' (FRAG.NO:1801) (SEQ. ID NO: 1814) 5'-GGCBGCB BGG-3' (FRAG.NO:1802) (SEQ. ID NO: 1815) TCC TCB TGG CTG GGG-3iil (FRAG. NO:I212) (SEQ. ID NO:1221) TOG GCC TGC BOG 0CC-3D (FRAG. NO:1213) (SEQ. ID NO:1222) -GCT CTT GCC TGG BGT GGC TC-3' (FRAG. NO:1214) (SEQ. ID NO:1223) CBG BGT CTT CCC TGG T-3' (FRAG. NO:1215) (SEQ. ID NO:1224) 2 0 5 CCGGGGCTGC BGCBBCCTCB TCBGCTCTTG CCTGG13GTGG CTCBGCCTGG GCCTGCBGGG CCBCCBGGBG BBTGGCBGCB BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC TBGCTBGGCB GGGTGBCCBG BGBGGGC- 3' (FRAG.NO:1803) (SEQ. ID NO: 1816) Human Defensin 2 Nucelic Acid and Antisense Olilonucleotide Fragments 5'-ATCC17TAAG TCAATGGACT TTGCATCAGT CACACCATCT TTrGTrACTT TGGACTTCCC CAGCTATGTT CAATAATTAC TGTTCTTCCC AGCATTAAGG CTCGGACAT( GTAGCCTGGA CACTGGTCTC OGACATOTOC ATOOCOAGG AGCAAATATA CAAAAAAAA CCATTTrCTCT GTATGCTTTC CAATTCCAGC CTGCTCAACA TCCCAGTCCT GGATGCATAl CATCAOAACC TTCITTT'FJTT TCAOCCTCCC AAATACCTG( AOATGGGOTT T1'GCCATGTI CTCCCAAACT OCTOGGATO.

CATTAAGOAT CTTGGCTGCY AGGTTCTTCA GAACCTGAC/ TGTCTCTGTC ACTOCTOCAC GCccTTAGAT CGAAAGAGO GTGCCCGGGA TGOOOCTCT( GGGTCCTOAG AGACACCAG CACCAACAGO GAGACCACO TOACOCTOAC GTCTGTGGAP ATTCCCTGAG TOACGGTOTC GGOTGAACTC TOAGGOAC GGOCATCCAT CTGCCTCATC TCACCAOCTC AGATCTCCTC TCCCAGOOTC CCTGGGTTTC ATTAGATOGA AAGAOCTCT( CAGAGTGGGC AGCAGGTGA CAGCCCCTCA CTCCATTCAC GCAGGAGGAA OGGATTTTC CiTrTGAGGAC CATTCTCTGA AATACCAGTT CTGAACTCTA CCCCAOACTC AGCTCCTGG~ CTCTrCATAT TCCTGATGCC AATGGCGTAG AAGTTCTCTI CCTCTCTCTO TGTGTCCCCT GTCTTTCTTT TTCCTCTCTC TrTAGACTGAA TGCCCTATTT ATOGACACCT CACTCGTTC'I TGCTTTCCAT GCTACAACTG AATTTTGATT TTATCTAAAG ACTGCAACCT AOAGAATTCC CTCTGCCTCC AGGAC'rTMC TTGGGCCCCA TTGTAATGGC AGCACCAAAT TTTACATCTI' ATCTGGTGAA AGACTOTOG C AGGTCATCAG CAGCAAGTGA A TAAATAAATT ATTAATTTAG TTCACCAGGA AGAAATAGTT CACAAGGAAA CAAAGCCCTG F TTGTTTAGCA GTTCTOACAG TYrTTTTCTT TOAGACTOAG TACAOCCTCG ACAAAAAGTC TACACTTTGA TACCATCACT TCAAGTOAOG TGAGGAGCCA TAATGGAAOC ATTTrCTGTOG GOTOCTOOCA OAGCTOCCTC TTACYITTCTA AAOGTGACAT GTAGAGCACA TAAAGGCTTT ATTTCATATT TTAGTGTCAG GAATGAATGA GTCTGCCCCT ACAATCAGAG TGACTCCCTG GTOACTAAOC CATTTGACCC AGCCCTCTCT CTOCATATCC TCTTGCTCTO TCGGAAGCGA CTCCTGTOCC k

A

T

AATTATAOGC GTAAGCCATC ATGCCTOGCT AATTTTTGTA YTTTCATGG GGTCAAATTG GTCTCACACT CCTGACCTCA TGTOATCCAC CTGCCTCAGC CAGGTGTAAG CCACCATGCT AGGCTCAGAA ATTTCCTr'F[ ATAAAAATGT CAATATCGTF ACCAGCTI'CC TI7TAAATCCA CTTCTGOCCT GCCAGGAATC TT7TAAATGA AGAGGTCAGG CAGTTCATGA GGAAAGCCTC A'17GTCCCCA CCCTGAOACA TCACAOACAT OGACACTGO GCCTGCTTGT TTCTCAAACT AGGAACCAGO ATGAATGCCA CTCATTTTCC CAAGAAAGGC CCTCTCCTGA TCCAT'rGCCT GGOCCOCCA ATTOCTACTC TGGTTACGG AGGAAGOACA

GACCTCACAC

GGAGGCCTTG

AGCAOAOAAA

AATGGAAGGA

AGCCCTGAAA ACATGOOCT CCYI7CATAAG TGTTTCCCAT CAGCCCCACT CGGTGCTI7CT CCACCAAATC CCAAGGOCAG OCCCTOGCTC CCAAAGCCCT GAAOTCCCTG TOOAGCTOAC ACTCAAGTOC OGGTOTAGO CCACCTCCTG GCCCAGGCCT A CATGTAGTCA CAATCCCATC CTCCCATrCT TCTCTCCCOT GOGGAAGATG GGGAGTTTCA TOAGOATOOG GCCCACCATG CTCCCGGTGC AGCCAGCCCT GTATCATCCC CAGGAOCTGA AATTTGACCT GAGACTGTCC CCAOATACTC G TGGCAGGTTA TAOOTCCTGA GTrTGAGTrT ACACTGGGTT TTAAATOGTG CAAGATAGGA T OGGGTTTCCT GAGTCCAGAT TI'OCATAAGA CTCACCAOOT AAGTGGCTGA ATTCTAACCT *CCTOGTOACC AGGOACCAGO ACCTrTATAA CC17CTCAGA

GGGGAACT

TOCCAGAGOC

ATGTCAOAOC

AGGAAAAACA

GTTCTCACGT

GCAA1T=CT

TCTCCTGAGT

CTGTAATGAG

GGTGGAAGGC

GGAAGGAAGT

CACATAAATr

CCTGAGCCCC

AATGGATAGA

GGACGTCGCA

GAGACAOACC

GGTCCCAAGA

GTGCATrGTr

CATTGCACCC

TTGATGTCCT

P GAAGCTCCCA GCCATCAGCC ATOAGGOTCT TOTATCTCCT C7I17CTCGTTC TCYITCCAGGT GAGATGOGCC AGOOAAATAO GAGGGTTGGC CAAATGGAAG G TCTCCTCTCA TTCCCCTCCA CCATCCTrTT

CCTAGAGCAT

AATTGAACAA

TCTAAGCCAA

CTOAOACTAT

AAAGTAGTAT

AGATAATCTT

CTCCTCYC

GTCTTTC1T

AGCATTGCTT

TATGAAOGAO

OGTTOAAACC

AGAATGTCAT

AAGGCCCAGC

CCCTOAGAAC

227 CCTATCTCTC CCTCATCCCT CTCTCTCCT[F TCTCTCT7CT TCCCTCTCTC TCTTITCT CTTTCTC1TTI CCTTTCTTCT ACCCACACTT CCTTrCAATAO AAAAGOAOTT TOAOAACCCA CCCAGTAGCT TGTAAATATC ATCTCTTCAC TOTTAGGTOA CTTrAAAT AAAAOGCAGA TTTFCTAAATT TTTATATTTA AAGGGTAOAT CTATACTGTG AGAACTACTG CAGCAAGACA AOTCCCTGCC ACTAGOCCAC TGCAGOTTCA TGATCAGAGG CAGGACAGGG TACAGCCCAT TGAAACCTAC TITAAACCT GGATGCCTAA CCTTCATT-IT CTCCYFGATA YUATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG GAGAGTGGAA GGGAAGGATG GAGAAAGGGA AAAAGAAAAT TTGAGAGTAA ATCCTAAAAC AAITAATCTA ATAGATATCA TCTfGTGAAA TCCTCATTTT ACCAATCTTA TTTATGAGTC CTGGGTTTTG TGAGAACAAT GGGGTTCTGA GAGGCACCAG AGACCTCATG YTITCCAAAA CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAGGGAG GCAGGGAGGC AGGGAGGCAG GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG GGAGGGAGGG AGGGAGGGAG GGAGGGATAA AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATrAG AAACAAGCCA TTACAAAATT TATTTCTATG

GTTAATTGTG

CTTTTTATCC

GTGTGTGTTA

TCG11TGCTGA

ATCAGGTTCT

CAAATGACTG

TTACTCAAGG

GCTCTJTTTJG

AGTGGAGCCA

GTTTrTCAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CATCTCAGGT CAAATACTTA ACAGACTAAA TGATTrTGAAA AAGCAAAAGT TTACTGGCTT AAATGGAGGT ATGGTGGCT-r TGATATTATC TTCTrGTGGT GGAGCTGAAT TCACAAGAGA GCTCCTACCA GACCCCACCT GGAGGCCCCA GTCACTCAGG AGAGATCAGG GTCTTrCACA ACAAAAATAA ACATCCCCCC AACCACAGCA GTGCCAGTTT CCATGTCAGA AACTTAGATC ACTCGCGTCT CATTATCATG ATGGAAAAGC CCAGGCTTGA GAAAGAAGCC CGCTGCGGAT CGATACTGAC ACAGGGTTTG TGTTTTTCCA ACATGAGTTT TGAGTTCTTA CACGCTGTTT TGTGTTTT CCCTGTTAGG TATGTCATCC AGTCTTrTGC GAACAAAATG CTGCAAAAAG CCATGAGGAG TCCCTCATCA GAGACGTGCG ACATGTAAAC CTAGTAATTG TGGTCATTGG GTGATGTTGG CTGCTCTCCA GGAAGGGGTC AGGGCTGCCA TA~rCT[TGG ATTCCTTGAC CTTCCCCATT TGTTTTTGGT GGTATAGGCG ATCCTGTTAC CTGCCTFAAG CCTAGAAGGT ATAAACAAAT TGGCACCTGT GGTCTCCCTG GCCAAGAAGC TGCTGTGGCT GATGCGGATT CAGAAAGGGC CAAATTAAAC TATGGTGTCC AAAGATACGC AATCTTTATC T-rTGGGCAGG CCATCTCTAA TATCCT-rGAA ACACCTrTTT CAGCGGGGCT TGGAGTGCTT TCCAGGGTCA CAGGCATCTG TATTCCCGGC ATTTTCCTAA AACGTGTGCT TJ7GCTCCTCC TGCATCCTCC CCTTGCATGC CCTCACCTAC CCCACATCT7 CCCTAAAAAA AGCAAGCCCA ACTCAAAGAC CAGTTCCCTC ATGGAATCAT AGTGGATCTG CCAAGGGAGG GGATGCCCAG TCCTCTGTTC TTCACAAGAC TCCCYITCTTC TGGCTAAGGT 'rrCTrTATGCA ATrAT GAATTCACAT TITCTCACCTT TTGATGTATT AAGAAAGTAT GGAGAAATAT ATCCTCTATC

TCCTTTACTG

TGTCTCCATr

MIAAGTTCA

FGCTAACCT

CCAGTCTCTC

T1TAAGTCAAT AATflACTGTT

TTAAGGCTCA

CCTGGACACT

ATGTGCATGG

AGTATACAAA

CTGTATGCTT

GCCTGCTCAG

TGGATGCATA

CTTCTITTT

CCAAATACCT

TTTTGCCATG

GTGCTGGGAT

ATCTTGGCTG

TCAGAACCTG

GTCACTGCTG

GATCGAAAGA

GGATGGGGCT

GAGAGACACC

AGGGAGACCA

GACGTCTGTG

AGTGACGGTG

TCTGAGGGGA

ATCTGCCTCA

TCAGATCTCC

CCCTGGGTT

AAAGAGCTCT

CAGCAGGTGA

ACTCCATTCA

AGGGATTC

CCATTCTCTG

TCTGAACTCT

CAGCTCCTGG

'rrCCTGATGC

GAAGTTCTCT

GTGTGTCCCC

TTrCCTCTC

TGATGATGCC

TGCAGAAATT

GCAATTACAG

TCTGGAAGGC

CATTTGTGTT

TGACTTTGCA

AAATTTTCAT

CTTTCTTCCA

GTAGCAACCT

CATCAACAGC

TTA11TTGGAA

ATITGGCAACA

TCAGTCACAC

GCCTTCAATA

AACTTTYJTCA

GTGCAAT"TC

TAACATCACA

ATAGAGCATA

TCTTGGACAA

CATCTTTTGT

AATGGCTACA

CATCT~rACC

TGTGGGTAAT

ATTTCTAATT

TTGCATCAGA

TTCAGGTTTG

CCTCTCYJ7GA

CCAGTACAGC

GTrTAGCTCC TACTI7TGGGA

GCATCGACAA

CATCAGTCAG

GATGATGTTA

GTCACAGGTT

TT'TCCACTGG

AGCAGTGATA

AATGC'TTTA

CTTCCCCAGC

AAAGTCTACA

TGTTTTTCCA

CCAATTTCTT

TAGACTGCTT

ATTAGCACCT

GTGCCATCCC

TATTTATCCT

TATGTTCAAT

CTTTGAAGCA CT7CCCTTTG GCCCCATTGT GACATCAGCA CCAAATT317A GGTCTCATCT GGTGAAAGAC TGAGGCAGGT CATCAGCAGC ATCACTITCAA GTGAGGTGAG GAGCCAGTAG GGAAGCATTT CTGTGGGGTG GTGGCAGGAC AAGTGAGAGC TGCCTCTTAC TTTCTAAAGG TGACATAGCA AAAAAATAAA ATATTAATTT AGGCAGAGCA CATAAAGGCT TTATJTTCATA TTCCATTTCT TCTTCACCAG GAAGAAATAG TTTTAGTGTC AGGAATGAAT GAGTCTGCCC CTCAATTCCA CACACAAGGA AACAAAGCCC TGACAATCAG AGTGACTCCC TGGTGACTAA 'TTGTTTAGC AGTTCTGACA GCATCTGACC CAGCCCTCTC TrGCATACC TTTFTTTTTC TY[rGAGACTG AGTCTTGCTC TGTCGGAAGC GATTCCCGTG GGAATTATAG GCGTAAGCCA TCATGCCTGG CTAA'TfTTG TATTTTCAT TTGGTCAAAT TGGTCTCACA CTCCTGACCT CATGTGATCC ACCTGCCTCA GACAGGTGTA AGCCACCATG CTAGGCTCAG AAATTTCCTT TTATAAAAAT CACAATATCG TTACCAGCTT CCYITAAATC CACCTCTGGC CTGCCAGGAA ACA1TTTTAAA TGAAGAGGTC AGGCAGGTCA TGAGGAAAGC CTCATfrGTCC CACCCCTGAG ACATCACAGA CATGGACACT GGGGCCTGCT TGTTTCTCAA GGGAGGAACC AGGATGAATG CCACTCAITT TCCCAAGAAA GGCCCTCTCC CTGTCCATTG CCTGGGGCCG CCAATTGCTA CTCTGGGTTA CGGAAGAAGG AGAGACCTCA CACAGCCCTG AAAACATGGG GCTCCYJTCAT AAGTGT-rTCC CGTGGAGGCC TTGCAGCCCT ACTCGGTGCT TCTCCACCAA ATCCCAAGGG GAAAGCAGAG AAAGCCCTGG CTCCCAAAGC CCTGAAGTCC TGTGGAGCTG TGAATGGAAG GAACTCAAGT GCGGGTGGTA GGCCACCTCC TGGCCCAGGC CACATGTAGT CACAATCCCA TCCTCCCATT CTCCTTCTCA GAGGAAGGAA TCTCTCTCCC GTGGGGAAGA TGGGGAGITr CAGGGAACT YTCACATAAA TGTGAGGATG GGGCCCACCA TGCTCCCGGT GCTGCCAGAG GCCCTGAGCC

GCTCCAGTCC

CCACCAGAAC

CCTCAGCCTC

GGAGATGGGG

GCCTCCCAAA

GTCATTAAGG

TCAGGGTTCT

CCATGTCTCT

ACTGCCCTTA

TGAGTGCCCG

ACAGGGTCCT

CATCACCAAC

CAGTGACGCT

ACAT-rCCCTG

CTGGGTGAAC

GTGGGCATCC

TTTCACCAGC

CCTCCAGGGT

GAGCCAGCCC

CAAYTTGGCC

GTGGCAGGTT

CACACTGGGT

TGGGGMICC

ACTCACCAGG

ACCTGGTGAC

TGAAGCTCCC

TGTATCATCC CCAGGAGCTG AATGTCCGAA CAATGGATAG AATTAGATGG TGAGACTGTC CCCAGATACT CAGGAAAAAC AGGACGTCGC ACAGAGTGGG ATAGGTCCTG AGTTTGAGTT TGTrCTCACG TGAGACAGAC CCAGCCCCTC 1TAAATGGT GCAAGATAGG AGGAATUC TGGTCCCAAG AGGAGGAGGA TGAGTCCAGA TI7GCATAAG ATCTCCTGAG TGTGCATTGT TCITGAGGA TAAGTGGCTG AATTrCTAACC TCTGTAATGA GCATITGCACC CAATACCAGT CAGGGACCAG GACCTTTATA AGGTGGAAGG Cfl7GATGTCC TCCCCAGACT AGCCATCAGC CATGAGGGTC TrGTATCTCC TCTTCTCG'rr CCTCYJ7CATA CTCTTCCAGG TGAGATGGGC CAGGGAAATA GGAGGGTTGG CCAAATGGAA GTCTCCTCTC ATTCCCCTCC ACCTATCTCT CCCTCATCCC TCTCTCTCCT TCCATCC1TT TCTCCTGCTT CTCTCTCTTC TTCCCTCTCT CTCT1TT TCCCTAGAGC ATGTC'FrTCT TFTCTTTCTCT 117CC1TJ7CTT CTACCCACAC

GAATGGCGTA

TCCTCTCTCT

CTGTC'TrTCT

T]IAGACTG

228 AGTAGACTGA ATGCCCTATT TAATTGAACC AAGCATTCICT TCCTI'CAATA GAAAAGGAGT TTGAGAACCC AATGGACAAC TCACTCGT[C TTCTAAGCCA ATATGAAGGA GCCCAGTAGT TTFGTAAATAT CATCTCTTCA CTGCTTTCCA TGCTACAACT GCTGAGACTA TGGTTGAAAC CTG17AGJGTG AtTrTTTAAA TAAAAGGCAG AAATTTTGAT TTTATCTAAA GAAAGTAGTA TAGAATGTCA T-rTTCTAAAT TTTTATATTT AAAGAGTAGA TACTGCAACC TAGAGAAUTC CAGATAATCT TAAGGCCCAG CCTATACTGT GAGAACTACT GCAGCAGACA CTCTGCCCCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGOG ACAGCCCATT GAAACCAACT TTTAAACCTG GATGCCTAAC C1TCATTTTC TCCTTGATAT TATGAAAATA AAATAAAAAC CATGAAAGGA TAAAAGAGGG AGAGTGGAAG GGAAGGATGG AGAAAGGGAA AAAGAAAATT TGAGAGTAAA TCCTAAAACA ATTAATCTAA TAGATATCAT CTJTGTGAAAT CCTCATTTTA CCAATCTTAT TTATGAGTCC TGGGTTTTGT GAGAACAATG GGGTTCTGAG AGGCACCAGA GACCTCATAT TTTCCAAAAC CTAGAACAGT ATAATGAAGG AAGGAGGGAA GGAGGGAGGG AGGGAGGGAA GGAGGGAAGG AGGGAGGGAG GGAGGGAAAC AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATAYI7AG AAACAAGCCA TrACAAAATT TATTTCTATG ACAATTTCAG TAAGTTGCAT AAAGCAAAAG YITACTGGCT TGGAGCTGAA TTCACAAGAG GAGAGATCAG GGTCTTfCAC TCCATGTCAG AAACTTAGAT AGAAAGAAGC CCGCTGCGGA T-rGAGTTCTT ACACGCTGTT GATCCTGT-rA CCTGCCTfAA GTrTAATTGTG

CT[TT'TATC

TGTGTGTGTT

ATCGTITGCTG

AATCAGGTTC

CCAAATGACT

1TTACTCAAG

TGCTCTTYTT

GAGTGGAGCC

3GAACAAAAT

CTCCCTCATC

CCTAGTAATT

GTTTCAACT GTAAGTJ7ACT TGGTGTTAAT CCATCTCAGA TCAAATACTT AACAGACTAA AAAATGGAGG TATGGTGGCT TTGATAYI7AT

AGCTCCTGCC

TACAAAAATA

GACTCGCGTC

GCGATACTGA

GTGTGTITT

ATATGTCATC

GCTGCAAAAA

AGAGACGTGC

GTGGTCATTG

AGACCCCACC TGGAGGCCCC AACATCCCCC AAACCACAGC TCATTATCAT GATGGAAAAG CACAGGGTTT GTGYTTTCC TCCCTGTTAG GTGTTTTTGG CAGTCTTTTG CCCTAGAAGG GCCATGAGGA GGCCAAGAAG GACATGTAAA CCAAATTAAA GGTGATGTTG GTTTGGGCAG

TTCCTATTAA

ATGATTTGAA

CTTCTTGTGG

AGTCACTCAG

AGTGCCAG1T

CCCAGGCTTG

AACATGAGTT

TGGTATAGGC

TATAAACAAA

CTGCTGTGGC

CTATGGTGTC

GCCATCTCTA

TJTGGCACCTG

TGATGCGGAT

CAAAGATACG

TGGTCTCCCT

TCAGAAAGGG

CAATCT17AT ATATCCY[GA AACAccUrTT TCTGCTCTCC AGGAAGGGGT CAGGGCTGCC ACAGCGGGGC TTGGAGTGC-3, (FRAG. NO:j (SEQ. ID NO:301 1) TTCTCACCTr TTGATGTAT AAGAAAGTAT GGAGAAATAT ATCCTCTATC AAATTTTCAT

GCCTTCAATA

AACTT1TTTCA GTGCAAT-r~c

TAACATCACA

ATAGAGCATA

TCTTGGACAA

CATC~rTTGT

AATGGCTACA

CATC~rTACC

TGTGGGTAAT

AAGTGAGAGC

ATTTCTAATT

TTGCATCAGA

TTCAGG'rrTG CCTCTCTI1GA

CCAGTACAGC

G'FITAGCTCC

TACTTTGGGA

GCATCGACAA

CATCAGTCAG

GATGATGTTA

GTCACAGGTTr 1TT7CCACTGG

AGCAGTGATA

AATGCTTT-rA

CTTCCCCAGC

AAAGTCTACA

TGTTTTTCCA TCC17JACTG TGATGATGCC CCAA1TI'CTT TGTCTCCAT7 TGCAGAAATT TAGACTGCTT T1TrAAGTTCA GCAATTACAG ATTAGCACCT TTGCTAACCT TCTGGAAGGC GTGCCATCCC CCAGTCTCTC CATTJTGTGTT TATT7ATCCT

TATGTTCAAT

CTTTGAAGCA

GAGCCAGTAG

GTGGCAGGAC

TGACATAGCA

ATCACTTCAA GTGAGGTGAG GGAAGCATTT CTGTGGGGTG TGCCTCT-rAC TT-rCTAAAGG

TTAAGTCAAT

AAT1TACTGTIr

TTAAGGCTCA

CCTGGACACT

ATGTGCATGG

AGTATACAAA

CTGTATGCTT

TGACTrFTGCA

CTTCCCTFTG

GACATCAGCA

GGTCTCATCT

TGAGGCAGGT

AAAAAATAAA

TCTTCACCAG

CT-rTCTTCCA

GTAGCAACCT

CATCAACAGC

TTATTTGGAA

ATTGGCAACA

TCAGTCACAC

GCCCCATrGT

CCAAATTTTA

GGTGAAAGAC

CATCAGCAGC

ATATTAATTT

GAAGAAATAG AGGCAGAGCA CATAAAGGCT T-TATTTCATA TTCCA'TfrCT M~TAGTGTC AGGAATGAAT GAGTCTGCCC CTCAAYFCCA GCCTGCTCAG CACACAAGGA AACAAAGCCC TGACAATCAG AGTGACTCCC GCATCTGACC CAGCCCTCTC AGTCTTGCTC TGTCGGAAGC TCATGCCTGG CTAATTTTUG CTCCTGACCT CATGTGATCC CTAGGCTCAG AAATI'TCCUT CCTIrAAATC CACCTCTGGC TGGTGACTAA GCTCCAGTCC TGGATGCATA TT-rGTTTAGC TrGCATACC CCACCAGAAC CTFCTTYI7TT TTTTTTTTTC GATTCCCGTG CCTCAGCCTC CCAAATACCT GGAATTATAG TATTTTrCAT GGAGATGGGG ThITTGCCATG TTGGTCAAAT ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT GACAGGTGTA TI1ATAAAAAT GTCAT[AAGG ATCTTGGCTG CACAATATCG CTGCCAGGAA TCAGGGTTCT TCAGAACCTG ACATTAAA

AGTTCTGACA

TT'TGAGACTG

GCGTAAGCCA

TGGTCTCACA

AGCCACCATG

TTACCAGCTT

TGAAGAGGTC

AGGCAGGTCA TGAGGAAAGC CTCATTGTCC CCATGTCTCT GTCACTGCTG CACCCCTGAG ACATCACAGA CATGGACACT GGGGCCTGCT TGTTTCTCAA CCACTCAMT TCCCAAGAAA GGCCCTCTCC CCAATTGCTA CTCTGGGT-rA CGGAAGAAGG AAAACATGGG GCTCCTTCAT AAGTGTTTCC ACTCGGTGCT TCTCCACCAA ATCCCAAGGG CTCCCAAAGC CCTGAAGTCC TGTGGAGCTG GCGGGTGGTA GGCCACCTCC TGGCCCAGGC TCCTCCCATT CTCCTTCTCA GAGGAAGGAA TGGGGAGTTT CAGGGGAACT T-rCACATAAA TGCTCCCGGT GCTGCCAGAG GCCCTGAGCC CCAGGAGCTG AATGTCCGAA CAATGGATAG CCCAGATACT CAGGAAAAAC AGGACGTCGC AGTTITGAGTT TG17CTCACG TGAGACAGAC GCAAGATAGG AGGAATTTTC TGGTCCCAAG TTfTGCATAAG ATCTCCTGAG TGTGCATTGT AATTCTAACC TCTGTAATGA GCATTGCACC GACCYTFATA AGGTGGAAGG CTYrGATGTCC CATGAGGGTC TTGTATCTCC TCTTCTCGTT ACTGCCCTTA GATCGAAAGA GGGAGGAACC AGGATGAATG TGAGTGCCCG GGATGGGGCT CTGTCCATTG ACAGGGTCCT GAGAGACACC AGAGACCTCA CATCACCAAC AGGGAGACCA CGTGGAGGCC CAGTGACGCT GACGTCTGTG GAAAGCAGAG ACATTrCCCTG AGTGACGGTG TGAATGGAAG CTGGGTGAAC TCTGAGGGGA CACATGTAGT GTGGGCATCC ATCTGCCTCA TCTCTCTCCC TTTCACCAGC TCAGATCTCC TGTGAGGATG CCTCCAGGGT CCCTGGGTTT GAGCCAGCCC AATTAGATGG AAAGAGCTCT CAATTTGGCC ACAGAGTGGG CAGCAGGTGA GTGGCAGGTT CCAGCCCCTC ACTCCATTCA CACACTGGGT AGCAGGAGGA AGGGATITTTC TGGGGTTTCC TCTTTGAGGA CCATTCTCTG ACTCACCAGG CAATACCAGT TCTGAACTCT ACCTGGTGAC TCCCCAGACT CAGCTCCTGG TGAAGCTCCC CCTCTrFCATA TTCCTGATGC CTCTTCCAGG

CCTGGGGCCG

CACAGCCCTG

T17GCAGCCCT

AAAGCCCTGG

GAACTCAAGT

CACAATCCCA

GTGGGGAAGA

GGGCCCACCA

TGTATCATCC

TGAGACTGTC

ATAGGTCCTG

T1TAAATGGT

TGAGTCCAGA

TAAGTGGCTG

CAGGGACCAG

AGCCATCAGC

TGAGATGGGC

CAGGGAAATA GGAGGGTTGG CCAAATGGAA GAATGGCGTA GAAGTrCTCT GTCTCCTCTC AITCCCCTCC 229

ACCTATCTCT

CTCTCTCTTC

'FrCTTTCTCT

AAGCATTGCT

ATATGAAGGA

CCCTCATCCC TCTCTCTCCT TCCTCTCTCT TTCCCTCTCT CTCTTTTY[T CTGTCTCT TTCCMTT CTACCCACAC TTTTAGACTG TCCTTCAATA GAAAAGGAGT TTGAGAACCC GCCCAGTAGT TfTGTAAATAT CATCTCTTCA GTGTGTCCCC TCCATCCTT TTTJTCCTCTC TCCCTAGAGC AGTAGACTGA ATGCCCTATT AATGGACAAC TCACTCGTrC CTGCTTTCCA TGCTACAACT TGG~rGAAAC CTGTTrAGGTG TAGAATGTCA TTTTCTAAAT TAAGGCCCAG CCTATACTGT CCCTGAGAAC AGTCCCTGCC UTTAAACCTG OATGCCTAAC TAAAAGAGGG AGAGTGGAAG ATTAATCTAA TAGATATCAT GAGAACAATG GGGTTCTGAG ACTTTfTAAA TAAAAGGCAG AAATTTTGAT TTTATCTAAA 1T[TATATTT AAAGAGTAGA TACTGCAACC TAGAGAATTC GAGAACTACT GCAGCAGACA CTCTGCCCCC AGGACTTTTC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG ACAGCCCATT CTTCA17TTC TCCTTGATAT TATGAAAATA AAATAAAAAC GGAAGGATGG AGAAAGGGAA AAAGAAAATT TGAGAGTAAA CTTGTGAAAT CCTCATTTTA CCAATCTTAT TTATGAGTCC AGGCACCAGA GACCTCATAT Y-FTCCAAAAC CTAGAACAGT

TCTCCTGCTT

ATGTCTTTCT

TAATTGAACC

TTCTAAGCCA

GCTGAGACTA

GAAAGTAGTA

CAGATAATCT

TGATCAGAGG

GAAACCAACT

CATGAAAGGA

TCCTAAAACA

TGGGTT[GT

ATAATGAAGG

AAGGAGGGAA GGAGGGAGGG AGGGAGGGAA GGAGGGAAGG AGGGAGGGAG GGAGGGAAAC AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TITACAAAATT TATTJTCTATG GTTAA17GTG GTTTrTCAACT C'TITTTATC CCATCTCAGA

TGTGTGTGTT

ATCGTTGCTG

AATCAGGUTC

CCAAATGACT

TTTACTCAAG

TGCTCTTT=

GAGTGGAGCC

GGAACAAAAT

CTCCCTCATC

CCTAGTAATT

AAAATGGAGG

AGCTCCTGCC

TACAAAAATA

GACTCGCGTC

GCGATACTGA

GTGTGTTIT

ATATGTCATC

GCTGCAAAAA

AGAGACGTGC

GTGGTCATTG

GTAAGTTACT TGGTGTI'AAT TCAAATACTT AACAGACTAA TATGGTGGCT TTGATATTAT AGACCCCACC TGGAGGCCCC AACATCCCCC AAACCACAGC TCATTATCAT GATGGAAAAG CACAGGGTTT GTGTTITTCC TCCCTGTTAG GTGTTTITGG CAGTCTTT-rG CCCTAGAAGG TTCCTATTAA ACAATTTCAG TAAGTTGCAT ATGATTTGAA AAAGCAAAAG TTTACTGGCT CTTCTTGTGG TGGAGCTGAA T-rCACAAGAG AGTCACTCAG GAGAGATGAG GGTCTTTFCAC AGTGCCAGTT TCCATGTCAG AAACTrAGAT CCCAGGCTTG AGAAAGAAGC CCGCTGCGGA AACATGAGTT U7GAGTTC'Tr ACACGCTGTT TGGTATAGGC GATCCTGTTA CCTGCCTfAA TATAAACAAA TTGGCACCTG TGGTCTCCCT

GCCATGAGGA

GACATGTAAA

GGTGATGTTG

GGCCAAGAAG CTGCTGTGGC CCAAATTAAA CTATGGTGTC GTTTGGGCAG GCCATCTCTA

TGATGCGGAT

CAAAGATACG

ATATCCTTGA

TCAGAAAGGG

CAATCTTTAT

AACACCTFT

TCTGCTCTCC AGGAAGGGGT CAGGGCTGCC ACAGCGGGGC T-rGGAGTGC-3' (FRAG. (SEQ. ID NO:2476) 5'-ATCC'UITAAG TCAATGGACT TTGCATCAGT CACACCATCT TTf7GTTACTT TGGACTTCCC CAGCTATGTT

CAATAATTAC

AGCATI7AAGG

GTAGCCTGGA

GGACATGTGC

AGCAAATATA

CCATTI'CTCT

CAATTCCAGC

TCCCAGTCCT

CATCAGAACC

TCAGCCTCCC

AGATGGGGTT

CTCCCAAACT

CATTAAGGAT

AGGTTC1TCA

TGTCTCTGTC

GCCCTTAGAT

GTGCCCGGGA

GGGTCCTGAG

CACCAACAGG

TGACGCTGAC

ATTCCCTGAG

GGGTGAACTC

GGGCATCCAT

TCACCAGCTC

TCCCAGGGTC

ATTAGATGGA

CAGAGTGGGC

CAGCCCCTCA

GCAGGAGGAA

cTITGAOOAC

AATACCAGTT

CCCCAGACTC

CTCTTrCATAT

AATGGCGTAG

CCTCTCTCTG

GTCTTTCYT

TI'AGACTGAA

TGTTCTTCCC T-rGGGCCCCA TTGTAATGGC CTCGGACATC AGCACCAAAT TTTACATCTT CACTGGTCTC ATCTGGTGAA AGACTGTGGG ATGGCGAGGC AGGTCATCAG CAGCAAGTGA CAAAAAAAAA TAAATAAATT ATTAATTTAG TACAGCCTCG ACAAAAAGTC TACACTTTGA TACCATCACT TCAAGTGAGG TGAGGAGCCA TAATGGAAGC ATTTCTGTGG GGTGCTGGCA GAGCTGCCTC 'ITACTT1TCTA AAGGTGACAT GTAGAGCACA TAAAGGCT'rr ATTTCATATT TTAGTGTCAG GAATGAATGA GTCTGCCCCT ACAATCAGAG TGACTCCCTG GTGACTAAGC CATTTGACCC AGCCCTCTCT CTGCATATCC TCTTGCTCTG TCGGAAGCGA CTCCTGTGCC

GTATGCTTTC

CTGCTCAACA

GGATGCATAT

T7CT-rTT1TT

AAATACCTGG

T-rGCCATGTT

GCTGGGATGA

CTTGGCTGCA

GAACCTGACA

ACTGCTGCAC

TFCACCAGGA AGAAATAGTT CACAAGGAAA CAAAGCCCTG TTGTTTAGCA GTTCTGACAG 1TfTTTCTT TGAGACTGAG

AATTATAGGC

GGTCAAATTrG

CAGGTGTAAG

CAATATCGT

TTUTAAATGA

CCCTGAGACA

GTAAGCCATC ATGCCTGGCT AATTITTGTA GTCTCACACT CCTGACCTCA TGTGATCCAC CCACCATGCT AGGCTCAGAA ATTTCCTTT[ ACCAGCTrCC YI'TAAATCCA CTTCTGGCCT AGAGGTCAGG CAGTTCATGA GGAAAGCCTC TCACAGACAT GGACACTGGG GCCTGCTTGT T-rTTTCATGG

CTGCCTCAGC

ATAAAAATGT

GCCAGGAATC

ATTGTCCCCA

TTCTCAAACT

CGAAAGAGGG AGGAACCAGG ATGAATGCCA CTCATTTTCC CAAGAAAGGC CCTCTCCTGA TGGGGCTCTG TCCATTGCCT GGGGCCGCCA ATTGCTACTC TGGGT[ACGG AGGAAGGACA AGACACCAGA GACCTCACAC AGCCCTGAAA ACATGGGGCT CCT-rCATAAG TGTFTTCCCAT GAGACCACGT GGAGGCCTTG CAGCCCCACT CGGTGCTTCT CCACCAAATC CCAAGGGCAG

GTCTGTGGAA

TGACGGTGTG

TGAGGGGACA

CTGCCTCATC

AGATCTCCTG

CCTGGGTITG

AAGAGCTCTC

AGCAGAGAAA GCCCTGGCTC CCAAAGCCCT GAAGTCCCTG TGGAGCTGAC AATGGAAGGA ACTCAAGTGC GGGTGGTAGG CCACCTCCTG GCCCAGGCCT CATGTAGTCA CAATCCCATC CTCCCA'I1TCT TCTCTCCCGT GGGGAAGATG GGGAGThITCA TGAGGATGGG GCCCACCATG CTCCCGGTGC AGCCAGCCCT GTATCATCCC CAGGAGCTGA AAITTGACCT GAGACTGTCC CCAGATACTC

CCTTCTCAGA

GGGGAAC'Tr

TGCCAGAGGC

ATGTCAGAGC

AGGAAAAACA

GTTCTCACGT

GCAATTTTCT

TCTCCTGAGT

CTGTAATGAG

GGTGGAAGGC

GGAAGGAAGT

CACATAAATT

CCTGAGCCCC

AATGGATAGA

GGACGTCGCA

GAGACAGACC

GGTCCCAAGA

GTGCA'rTGTT

CATTGCACCC

TTGATGTCCT

AGCAGGTGAG TGGCAGGTTA TAGGTCCTGA GTMGAGTTT CTCCAT1CAC ACACTGGGTT TTAAATGGTG CAAGATAGGA GGGATTfCT GGGGTTTCCT GAGTCCAGAT TTGCATAAGA CATFICTCTGA CTCACCAGGT AAGTGGCTGA ATTCTAACCT CTGAACTCTA CCTGGTGACC AGGGACCAGG ACCTrTATAA AGCTCCTGGT GAAGCTCCCA GCCATCAGCC ATGAGGGTCT TGTATCTCCT C117CTCGTTC TCCTGATGCC TCTTCCAGGT GAGATGGGCC AGGGAAATAG GAGGGTTGGC CAAATGGAAG AAGT-rCTCTG TCTCCTCTCA TTFCCCCTCCA CCTATCTCTC CCTCATCCCT CTCTCTCCT7 TGTGTCCCCT CCATCC1TT CTCCTGCTTC TCTCTCTI7CT TCCCTCTCTC TCYTTITCT TTCCTCTCTC CCTAGAGCAT GTCTTI'CTTrT CTTTCTCT~r CC11'TCTTCT ACCCACACT[ TGCCCTATTT AATTGAACAA AGCATfGCTT CCTCAATAG AAAAGGAGTT TGAGAACCCA 230 ATGGACACCT CACTCGTTCT TCTAAGCCAA TATGAAGGAG CCCAGTAGCT TGTAAATATC ATCTCTTCAC TGCTTTCCAT GCTACAACTG CTGAGACTAT GGTTGAAACC TGT7AGGTGA CTITTTAAAT AAAAGGCAGA AATT[TGATT TTATCTAAAG AAAGTAGTAT AGAATGTCAT TJTTCTAAATT TTTATATTTA AAGGGTAGAT ACTGCAACCT AGAGAATTCC AGATAATCTT AAGGCCCAGC CTATACTGTG AGAACTACTG CAGCAAGACA CTCTGCCTCC AGGAC1TTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG TACAGCCCAT TGAAACCTAC TTT"TAAACCT GGATGCCTAA CCTfCATTIT CTCCTrGATA TTATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG GAGAGTGGAA GGGAAGGATG GAGAAAGGGA AAAAGAAAAT TTGAGAGTAA ATCCTAAAAC AAUfAATCTA ATAGATATCA TCTrGTGAAA TCCTCATTTr ACCAATCTTA TTTATGAGTC CTGGOTTTTG TGAGAACAAT GGGGTTCTGA GAGGCACCAG AGACCTCATG TTTTCCAAAA CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAGGGAG GCAGGGAGGC AGGGAGGCAG GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG GGAGGGAGGG AGGGAGGGAG GGAGGGATAA AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAAYI7GTG GT~rTCAACT GTAAGTTACT TGGTGTAAT TTCCTAT-rAA ACAATTTCAG TAAGTTGCAT CTTTATCC CATCTCAGGT CAAATACTTA ACAGACTAAA TGATTTGAAA AAGCAAAAGT TTACTGGCTT

GTGTGTGTTA

TCGTTGCTGA

ATCAGGTTCT

CAAATGACTG

TJTACTCAAGG

GCTCTTG

AGTGGAGCCA

GAACAAAATG

TCCCTCATCA

CTAGTAATFTG

CTGCTCTCCA

TATTCT-TGG

TGCATCCTCC

CAGTTCCCTC

TCCCTTCTTC

GCACCCCAGA

GGCACCAATG

CTGGATGCAC

GTTGGAGCAT

GTGTACCAGT

TCTGAAGGCC

TCTTGGGT

AGATGATCCT

GGAACCACAT

AGCCCAGGTA

AAATGGAGGT ATGGTGGCT-r TGATAITATC TTC17GTGGT GGAGCTGAAT GCTCCTACCA GACCCCACCT GGAGGCCCCA GTCACTCAGG AGAGATCAGG ACAAAAATAA ACATCCCCCC AACCACAGCA GTGCCAGTTT CCATGTCAGA ACTCGCGTCT CATTATCATG ATGGAAAAGC CCAGGCT-rGA GAAAGAAGCC

TCACAAGAGA

GTCTTTCACA

AACTTAGATC

CGCTGCGGAT

CGATACTGAC ACAGGGTTTG TGTTIT7CCA ACATGAGT TGAGTTCTTA CACGCTGTTF TGTGYI1TTT CCCTG17AGG TGTTTTTGGT GGTATAGGCG ATCCTGTTAC CTGCCT-rAAG TATGTCATCC AGTCTTTTGC CCTAGAAGGT ATAAACAAAT TGGCACCTGT GGTCTCCCTG CTGCAAAAAG CCATGAGGAG GCCAAGAAGC TGCTGTGGCT GATGCGGATT CAGAAAGGGC GAGACGTGCG ACATGTAAAC CAAATTAAAC TATGGTGTCC AAAGATACGC AATCTTTATC TGGTCATTGG GTGATGTTGG 'TFTGGGCAGG CCATCTCTAA TATCCTTGAA ACACCTrTTTT GGAAGGGGTC AGGGCTGCCA CAGCGGGGCT TGGAGTGCTT TCCAGGGTCA CAGGCATCTG ATTCCUTGAC CTTCCCCATT TATTCCCGGC ATM~CCTAA AACGTGTGCT TTGCTCCTCC CCTJ7GCATGC CCTCACCTAC CCCACATCTT CCCTAAAAAA AGCAAGCCCA ACTCAAAGAC

ATGGAATCAT

TGGCTAAGGT

TACAACCTGA

CTTJAAACACC

AGGCTTCAAT

TGCATTCACA

GAAGGATGGA

CACAAGGCTG

GGCCATCTGG

AGACAATI7GT

GCCGCGTGTA

GCACTCAGTC

AGTGGATCTG

T[CT[ATGC.

CCTGTGTCCA

AGCAGCCCTC

CCAAGGGAGG GGATGCCCAG TCCTCTGT7C A ATTAT GAAUTCCCTG TAAGCCCTGT AGGCGGGCAA CTCAACCCTT AGATATTGAA ACAACCACAG ATCGTGTTTT AAGGATGAGG TTTTTATGGT TAGACCCCAG AGGTGGCATf CCTATCCCAA CTTAAATATT CCCYI7GGTGC GGAGCCATTG AGAATCCATA TCCTCTGTGG AGTTCTACflr TTTAATGGAC CCAACAGAAA AAGTCCACTT GTGCAGGGCT GGTCACCCTG CCTAGCTAGA GAAGCTATGC CTCCAATCTG TAGGAACGTC TGTCCGGACC CAAGCAGTTT ccTrCTAAAT GTCUTTGGAA CATTCT1TrG UTTTGCTATT GAGTTGTTGG AATATIfTTCT CTCATFrTTCT AGCG'FFAAAT GAAGCCACAC ATCATTACCT ACATCAATGT TACATTTAGG TTTTCAATTC CATATATAAA ATCATGAGGT AGGTGGAAAT AATAAACTTr CCTGATAAAA TCATTGTCCT TCTTCATGAG GATGGTAAGT GACACCAGAA TCTAGACCTC AGCCTGTJ7GA ATCAAAGTGC GGTGAACCCA CGAGTAACAT GGTACAGATG TATACTAGCA CTCTTATAAA ATGCACACCT CCAAATGGGC TCATGACGCC GCAGCACACA GAAAGCATCC AGACATGATC ATGGGCTCAG AACTCCTATG CCTCCCAGAA AGCACCACTC AGAGGCTGTG CAACACCAGC AGTAAAGTGA AAAGGCCACT CCCACCCTGA TGGCTAATGC TTAAGCTTAA ACTGTrCATI' GGCCAAGCAA CATCCAGATC TCAGGAGAAC CCAAAAATGT TCACCTGGGT GTTCTCCAAC ATCCCAGCTC GTCCTCGGGA CACTGCTTrTA GAAACACATT TCTCTUTGCA GGGCGTATAC TGTGATACGC AGGTAGTTCA GCTTAGCCAC AGCCAATGCA GTTGGTTGCT GCCTGGGCCT GGCCAGGGCT TAACCTCACC TI'CCCACCAA A1TrrCTCAAC GTAACCCGG AAAYFAGGAC ACCTCATCCC GCTCCTTGCT ATAGAAGACC TGGGACAGAG GGATCTGTAA GTACTACAAA AC'FUAAACTT

CCCAGTCTGC

GGATACACCT

AAGCTTTTGC

ATGCCCAGAC

CTCAGACCAG

ACAGGTGATA

CTGTTCCACA

AGCCAAATGG

CCAAATCCTC

AGCCAGGCTG

TCACAGGGTC

GACCAAGGTA

TGTCCTrGCC

AAAAGACCTT

GACTGCTGTC

TACACTGAGT

TTCACAAGAC

TACAGGGGCT

TGGGTCCCAT

AGGTAGTTCT

AGCCTGAAGA

G17CTCCGAT

TGAATGCTTC

TCCCACCTCC

T-rCTTGGCCC

GTACCTCTGG

TAGCAACAGA

C1CATTAG

CTCTGTGTGC

TCCCAGAGGC

AACTGTGTTA

GATGAGAGGT

ACCACAATTA

TAAATAGGGG

TGCCCTCTCT

TTTCATCAT[

GAATCCCTGC

TAGAGAAACT

ACTATCACAG

GTTGTT-rGAT

AGGTTTTGCA

CAGATGCTTTr

TAGCCAAGAA

1TrCAGTTGT

ACCTCTGACT

TCTGGTGACT

ACACATGTCA

AGAGAAACCT

AATTCCTTAT

GGG11TATCYI7 TTGTCTATTf

CAAAAGCTTT

OTGGGGCCGC

GCTGGGGACG

CATGTCCTGG

ATTTAGGTCC

GTATTCAGAT

TTCACTCGGT

TCCC3TI7TAT

ATCCTJTCTAT

CCCAGAGGGA

ATGGCTTCCA

T-rGACATGTC

TITGGTCTGTT

A3TGCCCCT TGAT-rGTTTC

TGCCTGTGCC

ACACTTCTAG

CCCAGCGGGT

GCTAACTTAA

CAGTAAGAAG

11TTCAATCAG

TCTGCCATGT

C1TIGCTGTG T-rTGGTGTCA

TAGTATGG

ATfCTGAGTT GATGITCCTA CATGGTGTGA GATAAAGATT TAAATACATA AGTGTACACT ATAAATATAC AATTGTTAAT CnT=TA CTTAAACCAC TCTGTGTCAC CTCCACCCTG ATTCCTACAG GAGACTACTC CACCTGAATC CTGAAGTGAA CAGAGAACAG CAGGACCCAT AATTTCTAUT CThIrfGGAA AGCAGGGTCT TTCTTGTCAT TGAAACTGGG AGAACAGGAG CCTCTCACTG AGATTGAGGA

TI'ACTCGCTA

CTrCAGAAAA

TGTTAAAAAG

TATTAGCTCC

CATTCGAGCA

AGGTTTCTTG

CTGCTCCTGC

TGTJ7ACTCAA

TGAGCTGATT

ACCCCATAAC

TTrCCATrGGA

TAAGAAGCAT

TGAATCATAA

AACCTAGCAC

ACCTJTGAGAC

TCTCCGAGCC

TCTCCCTCCT

GTCTAAGTAG

TCACCTTTAG

CTCAAAAACC

ACTCATATAG

*TTGTTCCCTG

TATTTAAGCA

AGACATTAAA

CAATGGGCCT

17CTCCCAGT

CCAGGTGACC

AGAGCTATAA ATCCAGGCTG GCTCCTCCCT CCCCACACAG CCAGCCATGA GGACCCTCGC CATCCUrGCT GCCAI1'CTCC TGGTGGCCCT GCAGGCCCAG GCTGAGCCAC 231 TCCAGGCAAG AGCTGATGAG GTTGCTGCAG CCCCGGAGCA GAT-rGCAGCG GACATCCCAG TTCCCTTGCA TGGGACGAAA GCTTGGCTCC AAAGCATCCA GGTGAGAGAG GCAGGCATGC AGTCTAGAGG GAAGGACGGG AGAGAGGTTC CAGAGTTGGG TCTCAGCAGT CTATGTCACT

AAGTGGTTGT

AGAGCTGCTA

GAGGTGGCTT

CACTTAGAAT CTCTGGGCAT TGATTCTC T-TTATTTCTC CAAAGACTTG A'FrCCAAGAA GACTAGTTAT TTCTGGATCT AAACAAGTAG AGCTTTTAAA AACTGCAGCC AAGCCTGAGG ATGAGAGCAA AGGAGAATGA GTCTCAAATT CTGAGGTTGT TCGTGCTACC GGCTGCAATG GATTCTTTTT CTTACCCACT GCTAACTCCA AAAACATGGA CTGCTATTGC AGAATACCAG CCAGGGAAGA CTCTGGGCAT TCTGCTGCTG ATCTAGAAAT TGAACAGAGA GCCAAATAAA CCTGAGAAAC

ACATCTGTGA

ACUrAGTTGT

GTAAGTTCAG

CTGTGTGACA

CAGCCAGCAT

TACTCAATTT

CGTGCATFGC

AGCTTGCAGA

AATTCACTAA GTTTAAGATA TGAAGAGACA AAAGAGAACA TITTACTCTA TCTACAGAAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA AGCACTGCTC TGCGTGTA TTCCTATCGA CACCTGTCAG CTAGCATGTG ACTTCCCCGA CTCATGCTCT CCCTGTCCCA GGCTCAAGGA AGGAGAACGT CGCTATGGAA CCTGCATCTA AAAAGAAAAA TGAGCTCAAA AUrTGCTTTG CAA1TITCCTT TCCTCATCTC AAATAAATGC GATATGTGTC TGTGTCAAGA CACTTGGGAT (FRAG. (SEQ. ID NO:3012) AGAGCTACAG GGAATTGCTA TTFACTCCTGT ACCT-rCTGCT CTTGTTACAA GATTTCTGTG TITCCACCTC TTTAATGTGT ACACGTACCA AAACGCAAAA TCAAAT1TTTT GAACAATATA-3- Human Defensin 3 Nucleic Acid and Antisense Oligonucleotide Fragments TGCTCCGGGG CTGCBGCBBC CTCBTCBGCTC T-rGCCTGGBGTG GCTCBGCCTGG GCCTGCBGGG CCBCCBGGBGB BTGGCBGCBBG GBTGGCGBGGG TCCTCBTGGC TGGGGTCBCCT GGBGGBGGGB GBGCBGGGGG TCCTCBTGGC TGGGGTCCCT CTCTCCCGTC CT CCTACCTTGC TATAGAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT GCCTAGCTAG AGGATCTGTG ACCCCAGCCA TGAGGACCCT CGCCATCCUT GCTGCCATTC TCCTGGTGGC CCTGCAGGCC CAGGCTGAGC CACTCCAGGC AAGAGCTGAT GAGGTTGCTG CAGCCCCGGA GCAGATTGCA GCGGACATCC CAGAAGTGGT TGYFI7CCCTf GCATGGGACG AAAGCTTGGC TCCAAAGCAT CCAGGCTCAA GGAAAAACAT GGACTGCTAT TGCAGAATAC CAGCGTGCAT TGCAGGAGAA CGTCGCTATG GAACCTGCAT CTACCAGGGA AGACTCTGGG CATTCTGCTG CTGAGCTTGC AGAAAAAGAA AAATGAGCTC AAAATTTGCT TTGAGAGCTA CAGGGAATTG CTATTACTCC TGTACCTJTCT GCTCAAYIC CfT-3' (FRAG. NO: 1804) (SEQ. ID NO:3013) TATAGAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT GCCTAGCTAG AGGATCTGTG ACCCCAGCCA TGAGGACCCT CGCCATCCTTr GCTGCCATTC TCCTGGTGGC CCTGCAGGCC CAGGCTGAGC CACTCCAGGC AAGAGCTGAT GAGGTTGCTG CAGCCCCGGA GCAGATTGCA GCGGACATCC CAGAAGTGGT TGTTTCCCT-r GCATGGGACG AAAGCTTGGC TCCAAAGCAT CCAGGCTCAA GGAAAAACAT GGACTGCTAT TGCAGAATAC CAGCGTGCAT TGCAGGAGAA CGTCGCTATG GAACCTGCAT CTACCAGGGA AGACTCTGGG CATTCTGCTG CTGAGCTTGC AGAAAAAGAA AAATGAGCTC AAAATT'TGCT TTGAGAGCTA CAGGGAATTG CTA1F7ACTCC TGTACCTTCT GCTCAATTTC CTT-3- (FRAG. NO:- (SEQ. ID NO:2478) TAAGCCCTGT TACAGGGGCT GCACCCCAGA TACAACCTGA CCTGTGTCCA AGGCGGGCAA CTCAACCCT AGATAYFGAA TGGGTCCCAT GGCACCAATG ATCGTGTTT-r AAGGATGAGG

GCAGCACACA

ATGGGCTCAG

AGCACCACTC

AGTAAAGTGA

TGGCTAATGC

GGCCAAGCAA

CCAAAAATGT

ATCCCAGCTC

GAAACACATT

TGTGATACGC

AGCCAATGCA

GGCCAGGGCT

A'TTTCTCAAC

ACCTCATCCC

TOGGACAGAG

ACTTAAACTU

CCCAGAGGGA

ATGGCTTCCA

TJ7GACATGTC T7GGTCTGTT

ATTUGCCCCT

TGATUGT11TC

TGCCTGTGCC

ACACTTCTAG

CATGGTGTGA

AATTGTJTAAT

TCTGTGTCAC

GAGACTACTC

TJTACTCGCTA

CCCAGTCTGC

GGATACACCT

AAGCTTTTGC

ATGCCCAGAC

CTCAGACCAG

ACAGGTGATA

CTGTTCCACA

AGCCAAATGG

CCAAATCCTC

AGCCAGGCTG

TCACAGGGTC

GACCAAGGTA

AGGTAGTTCT

AGCCTGAAGA

GTTCTCCGAT

TGAATGCU'C

TCCCACCTCC

TTCTTGGCCC

GTACCTCTGG

TAGCAACAGA

CTTTCATTAG

CTCTGTGTGC

TCCCAGAGGC

AACTGTGTTA

CTGGATGCAC

GTTGGAGCAT

GTGTACCAGT

TCTGAAGGCC

TTTCTTGGGT

AGATGATCCT

GGAACCACAT

AGCCCAGGTA

TrTTTATGGT

AGGTGGCATT

CT'TAAATATT

GGAGCCATTG

CTTAAACACC AGCAGCCCTC AGGCTTCAAT CCAAATGGGC TGCATTrCACA GAAAGCATCC GAAGGATGGA AACTCCTATG CACAAGGCTG AGAGGCTGTG GGCCATCTGG AAAGGCCACT AGACAATTGT TTAAGCTTAA GCCGCGTGTA CATCCAGATC GCACTCAGTC TCACCTGGGT TAGACCCCAG GTCCTCGGGA CCTATCCCAA TCTCYITGCA CCCTTGGTGC AGGTAGTTCA AGAATCCATA GTTGGTTGCT

ACAACCACAG

TCATGACGCC

AGACATGATC

CCTCCCAGAA

CAACACCAGC

CCCACCCTGA

ACTGTTCATT

TCAGGAGAAC

GTTCTCCAAC

CACTGCTTTA

GGGCGTATAC

GCTITAGCCAC

GCCTGGGCCT

GATGAGAGGT TCCTCTGTGG AGTTCTACTT TAACCTCACC TrCCCACCAA TGTCCTJTGCC ACCACAATTA TTTAATGGAC CCAACAGAAA GTAACCCCGG AAATTAGGAC

AAAAGACCTUF

GACTGCTGTC

TACACTGAGT

CCCAGCGGGT

GCTAACTTAA

CAGTAAGAAG

TCAATCAG

TCTGCCATGT

CT-17GCTGTG

TTITGGTGTCA

TAGTTTATGG

GATAAAGATT

TGYJ7ACTCAA

TGAGCTGATT

ACCCCATAAC

TAAATAGGGG

TGCCCTCTCT

TTrCATCATT

GAATCCCTGC

TAGAGAAACT

ACTATCACAG

GTTGTITTGAT

AGGTTTTGCA

CAGATGCT

TAGCCAAGAA

TY-rCAG'rrGT

TAAATACATA

GTCTAAGTAG

TCACCTTTAG

CTCAAAAACC

AAGTCCACTT GTGCACGGCT GGTCACCCTG CCTAGCTAGA GAAGCTATGC CTCCAATCTG TAGGAACGTC TGTCCGGACC CAAGCAGTTT CC'rrCTAAAT GTCTTTGGAA CA'rrCTTTTG TT=GCTATT GAGTTGTTGG

AATATTCT

AGCGTTAAAT

ATCATTACCT

TACA1TTTAGG

CATATATAAA

AGGTGGAAAT

CCTGATAAAA

TCTTCATGAG

CTCA1TJCT

GAAGCCACAC

ACATCAATGT

TTTTCAATTC

ATCATGAGGT

AATAAACTTT

TCATrrGTCCT

GATGGTAAGT

GCTCCT-rGCT

GGATCTGTAA

ACCTCTGACT

TCTGGTGACT

ACACATGTCA

AGAGAAACCT

AATFCCTTAT

GGGTUATC1T

TTGTCTATTT

CAAAAGCTTT

ATTCTGAGTT

AGTGTACACT

C~TTTMTA

CTCCACCCTG

CACCTGAATC

ATAGAAGACC

GTACTACAAA

GTGGGGCCGC

GCTGGGGACG

CATGTCCTGG

ATFIrAGGTCC

GTATTCAGAT

TTCACTCGGT

TCCCTI=AT

ATCCTTCTAT

GATGTTCCTA

ATAAATATAC

CTI'AAACCAC

ATITCCTACAG

CTGAAGTGAA

TTCCATTGGA ACTCATATAG GACACCAGAA TCTAGACCTC CAGAGAACAG CAGGACCCAT CTrCAGAAAA TAAGAAGCAT TTrGTTCCCTG AGCCTGTTGA ATCAAAGTGC AAT1CTATT CT1TrGGAA 232 TGTTAAAAAG TGAATCATAA TATTTAAGCA GGTGAACCCA CGAGTAACAT AGCAGGGTCT TTCTTGTCAT TATTAGCTCC AACCTAGCAC AGACATTAAA GGTACAGATG TATACTAGCA TGAAACTGGG AGAACAGGAG CATTCGAGCA ACCTTGAGAC CAATGGGCCT CTCTTATAAA ATGCACACCT CCTCTCACTG AGATTGAGGA AGGTTFTCTTG TCTCCGAGCC TTCTCCCAGT AGAGCTATAA ATCCAGGCTG GCTCCTCCCT CCCCACACAG CTGCTCCTGC TCTCCCTCCT CCAGGTGACC CCAGCCATGA GGACCCTCGC CATCCTTrGCT GCCATTCTCC TGGTGGCCCT GCAGGCCCAG GCTGAGCCAC TCCAGGCAAG AGCTGATGAG GTTGCTGCAG CCCCGGAGCA GATTGCAGCG GACATCCCAG AAGTGGT7GT TTCCCTI'GCA TGGGACGAAA GCTTGGCTCC AAAGCATCCA GGTGAGAGAG GCAGGCATGC AGAGCTGCTA AGTCTAGAGG GAAGGACGGG AGAGAGGTTC CAGAGTTGGG TCTCAGCAGT CTATGTCACT GAGGTOGCTT CACTTAGAAT CTCTGGGCAT TGATTTTCTC ATCTAGAAAT TGAACAGAGA GCCAAATAAA CCTGAGAAAC T-r[AT17CTC CAAAGACTTG ATTCCAAGAA ACATCTGTGA AATTCACTAA GTTTAAGATA TGAAGAGACA GACTAGTTAT TTCTGGATCT AAACAAGTAG ACTTAG'FrGT AAAGAGAACA TTTTACTCTA TCTACAGAAG AGCTT'ITAAA AACTGCAGCC AAGCCTGAGG GTAAGTTCAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA ATGAGAGCAA AGGAGAATGA GTCTCAAATT CTGTGTGACA AGCACTGCTC TGCGTGTrTA TTCCTATCGA CTGAGGTTGT TCGTGCTACC GGCTGCAATG CAGCCAGCAT CACCTGTCAG CTAGCATGTG ACTTCCCCGA GATTCTT-TT CTTACCCACT GCTAACTCCA TACTCAA1TTT CTCATGCTCT CCCTGTCCCA GGCTCAAGGA AAAACATGGA CTGCTATfGC AGAATACCAG CGTGCATTGC AGGAGAACGT CGCTATGGAA CCTGCATCTA CCAGGGAAGA CTCTGGGCAT TCTGCTGCTG AGCTTGCAGA AAAAGAAAAA TGAGCTCAAA ATflTGCTTTG AGAGCTACAG GGAATTGCTA TTACTCCTGT ACCTTCTGCT CAATTTCCTr TCCTCATCTC AAATAAATGC CTTGTTACAA GATTTCTGTG TTTCCACCTC TTrAATGTGT GATATGTGTC TGTGTCAAGA CACTGGGAT ACACGTACCA AAACGCAAAA TCAAATTr GAACAATATA-3- (FRAG. NO:_ (SEQ. ID NO:2477) 5'-GGCBGCBBGG-3' (FRAG. NO:1805) (SEQ. ID NO:1818) CTG GGG-3- (FRAG. NO:1806) (SEQ. ID NO:1819) 5'-GGGGTCBCC-3- (FRAG. NO:1807) (SEQ. ID NO:1820) 511-GGG TCC TCB TGG CTG GGG TC-3U (FRAG. NO:1216) (SEQ. ID NO:1225) MR-=C CTC TCC CGT CCT-30 (FRAG. NO:1217) (SEQ. ID NO:1226) TGCTCCGGGG CTGCBGCBBC CTCBTCBGCTC TTGCCTGGBGTG GCTCBGCCTGG GCCTGCBGGG CCBCCBGGBGB BTGGCBGCBBG GBTGGCGBGGG TCCTCBTGGC TGGGGTCBCCT GGBGGBGGGB GBGCBGG-3' (FRAG. NO:1808) (SEQ. ID NO:1821) Human Macrophage Inflammatory Protein-l-alpha/RANTES Receptor Nucleic Acid and Antisense Oligonucleotide Fragments 51]-GTCTTTGTTT CTGGGCTCGT GCCCCBTCCC GGCTTCTCTC TGGT1TCCGTC CTCTGTGGTG TfrGGCCCTG CTTCCT-rTTG CCTGTTGAGG GGGCAGCAGT TGGGCCCCAA AGGCCCTCTC GTTCACCTTC TGGCACGGAGTT GCATCCCCATA GTCAAACTCT GTGGTCGTGT CATAGTCCTC TGTGGTGTTT GGAGU-TCCA TCCCGGCTrrC TCTCTGGTTC CAAGGGAGB GGGGGCBGCB GTTGGGCCCC BBBGGCCCTC TCGTTCBCCT TCTGGCBCGG BGTTGCBTCC CCBTBGTCBB BCTCTGTGGT CGTGTCBTBG TCCTCTGTGG TGTTTGGBGT TTCCBTCCCG GCTTCTCTCT GGTTCCBBGG GB-3' (FRAG. NO:1809) (S EQ.ID NO:1822) CC-3- (FRAG. NO:1810) (SEQ. ID NO:1823) 5'-GGGGGCBGC-3' (FRAG. NO:1811) (SEQ. ID NO:1824) 5'-CCCGGCTTC-3' (FRAG. NO:1812) (SEQ. ID NO:1825) TTT GTT TCT GGG CTC GTG CC-30 (FRAG. NO:1218) (SEQ. ID NO:1227) 51i-CCB TCC CGG CTT CTC TCT GGT TCC-3U (FRAG. NO:1219) (SEQ. ID NO:1228) 512-GTC CTCTGT GGT GT-r TGG-30 (FRAG. NO:1220) (SEQ. ID NO:1229) 515-CCC TGC TTC CTrTTG CCT GTT3ii (FRAG. NO:1221) (SEQ. ID NO:1230) 5'-GAGGGGGCAG CAGTTGGGCC CCAAAGGCCC TCTCGTTCAC CTTCTGGCAC GGAGTTGCAT CCCCATAGTC AAACTCTGTG GTCGT-3' (FRAG. NO:1222) (SEQ. ID NO:1231) 5'-GTCATAGTCCTCTGTGGTGTTTGGAGTTTCCATCCCGGCTTCTCTCTGGTTGCAAGGGA-3' (FRAG.NO: I 223)(SEQ.ID NO:1 232) CBGTTGGGCC CCBBBGGCCC TCTCGTTCBC C17CTGGCBC GGBGTTGCBT CCCCBTBGTC BBBCTCTGTG GTCGTG-3' (FRAG. NO:1224) (SEQ. ID NO:1233) 5'-TCBTBGTCCTCTGTGGTGTTGGBGTTTCCBTCCCGGCT'rCTCTCTGGTTCCBBGGGB-3'(FRAG. NO: I 225)(SEQ.

ID NO:1234) RANTES Antisense Oliiwnucleotide Fraizments CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTGGGGBGGC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG CCGCGGBGBC cTFrCBTGGTB CCTGTGGBGB GGCTGTCGGB GGGGGTGTGG TGTCCGCTTG GCGGTTCT CGGGTGTTTC TrCTCTGGGT TGGCCTGCTG CTCGTCGTGGT CGCTCCGCTC CCGGGTTCGT CTCGCTCTGT CGCCCCT-fCC TTCCT1TGTCG TGYJTCCTCCC TI7CCYI7GCCT CT-3' (FRAG. NO: 1813) (SEQ. ID NO: 1826) 5'-GGGYTGGC-3- (FRAG. NO: 1814) (SEQ. ID NO: 1827) 5'-CGGGG CBG-3' (FRAG. NO: 1815) (SEQ. ID NO: 1828) 5'-CCCGGG-rrCG-3' (FRAG. NO: 1816) (SEQ. ID NO: 1829) 5'-GGGTGTGGTG-3' (FRAG. NO: 1817) (SEQ. ID NO: 1830) CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTGOGGBGGC BGBTGCBGGB GCGC-3- (FRAG. NO:1226) (SEQ. ID NO:1235) 5'-BGBGGGCBGTB3 GCBBTGBGGB TGBCBGCGBG GCGTGCCGCG GBGBCCTCB TGGTBCCTGT GGBGBGGCTG TCGGBGG-3- (FRAG. NO:1227) (SEQ. ID NO:1236) 233 5'-GGGTOTGGTGTCCGCTTGGCGOTTCTTTCGGGTGTTTCTTCTCTGGGTTGGCCTOCTGCTCGTCGTGGTC-3Y (FRAG. NO:1228) (SEQ. ID NO:1237) 5'-GCTCCGCTCCCGGGT[CGTCTCGCTCTOTCGCCCCTUTCCTTrCCTTGTCGTGTTCCTCCCTrCCTTGCCTCT-3- (FRAG. NO:1229) (SEQ. ID NO:1238) 5'-GOGTGTGGTGTCCO-3' (FRAG. NO:1230) (SEQ. ID NO:1239) 5'-CTUGGCGGTTCTTTCGGGTG-3' (FRAG. NO:1231) (SEQ. ID NO:1240) 5'-'TrCTTCTCTGOOTTGGC-3* (FRAG. NO:1232) (SEQ. ID NO:1241) 5'-CTGCTGCTCGTCGTGGTC-3' (FRAG. NO:1233) (SEQ. ID NO:1242) 5'-GCTCCGCTCCCGGGTTC-3' (FRAG. NO:1234) (SEQ. ID NO:1243) 5'-GTCTCGCTCTGTCGCCC-3' (FRAG. NO:1235) (SEQ. ID NO:1244) 5'-CTTCCTTCCTrGTC-3- (FRAG. NO:1236) (SEQ. ID NO:I245) 5'-GTGTTCCTCCCTTCCTTGCCTCT-3' (FRAG. NO:1237) (SEQ. ID NO:I246) CBGTGGGCGG GCBBTGTBGO CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTGGGGBGOC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG CCGCGGBGBC CTITCBTGGTB CCTGTGGBGB GGCTGTCGGB GG-3' (FRAG. NO:1818) (SEQ. ID NO:I831) Human Muscarinic Acetylcholine Receptor HMl* Nucleic Acid and Antisense Oligonucleotide Fragments GGGGTGTGCG CTTOGCOCTC CCGTGCTCGG TTCTCTGTCT CCCGGTCCCC CTTGCCTGGC GTCTCGGGCC TJTCGTCCTCT TCCTCTTCTTr CCT-rCCGCTC CGTGGGGGCT GCTTGGTGGG GGCCTGTGCCT CGGGGTCCCG GGGCTTCTGG CCCTTGCCGT TCATGGTGGC TAGGTGGGGC GTTCBTGGTG GCTBGGTGGG GC- 2 0 3'(FRAG. NO:1819)(SEQ. ID NO: 1832) 5'-GGTGGGGC-3' (FRAG. NO:1820) (SEQ. ID NO: 1833) 5'-GCCCGGCGGGG-3' (FRAG. NO:1821) (SEQ. ID NO: 1834) GGC TTC TOG CCC-3' (FRAG. NO:I1822) (SEQ. ID NO: 1835) CBT GGT GGC TBG GTG GOG C-30 (FRAG. NO:1238) (SEQ. ID NO:1247) 5D-GCT 0CC CGG CGG GGT OTG CGC rro GC-3D (FRAG. NO:1239) (SEQ. ID NO:1248) 51i-GCT CCC GTG CTC GGT TCT CTG TCT CCC GGT-30 (FRAG. NO:1240) (SEQ. ID NO:1249) CCT T-rG CCT GGC GTC TCG G-30 (FRAG. NO:1241) (SEQ. ID NO:1250) 514-GCC 'fTC GTC CTC TTG CTC WIC TTC CT-U CC-3D (FRAG. NO:1242) (SEQ. ID NO:1251) CCG TOO GGG CTG CT T GGT GGG GGC CTG TGC CTC GGG GTC C-3D (FRAG. NO:1243) (SEQ. ID NO:1252) GGC 'TC TGG CCC TUG CC-3D (FRAG. NO:1244) (SEQ. ID NO:1253) CAT GOT GGC TAG GTG GGG C-3- (FRAG. NO: 1245) (SEQ. ID NO:1254) Human Muscarinic Acetyicholine Receptor HM3* Nucleic Acid and Antisense Oligonucleotide Fragments GTG GOT BGG CCG TGT CTG GGGTT GOC CBT GTT GGT TGC CTCT TGG TOO TOC 0CC GGG CGCG TCT TGG CTT TCT TCT CCT TCG GGC CCT CGG GCC GGT OCT TOT GOCT CCT CCC GGG COG CCT CCC CG GCG GGG GCT TCT TGGCG CTG GCG GGG GGG CCT CCTGCT CTG TGG CTG GOC GTT CCT TGG TGT TCT GOG TGGTGG CG GCG TGG TGG CCT CTG TGGGGG CCC GCG GCT GCB GGG GTTG CCT GTC TGC TTC GTCCTU TGC GCT CCC GGG CCG CCGGG GTG GGT AGO CCG TOT CTG GGGGTT GOC CAT OTT GOT TG COOG CCC OCO OCT GCA GOG 0-3' (FRAG. NO:1823) (SEQ. ID NO:1836) S'-CCC GOG CGG-3' (FRAG. NO:1824) (SEQ. ID NO:1837) OCO 000 000 CC-3' (FRAG. NO:1825) (SEQ. ID NO:1838) 000 CCO CC-3' (FRAG. NO: 1826) (SEQ. ID NO: 1839) CCG TGT-3' (FRAG. NO:1827) (SEQ. ID NO:1840) OTO GOT BOO CCO TOT CTO 000-3D (FRAG. NO:1246) (SEQ. ID NO:1255) 5D]-GTT GGCCBTGOTTGTTGC C-3Di (FRAG. NO:1247) (SEQ. ID NO:1256) TOGTOC 0CCG000C-3D (FRAG. NO:1248) (SEQ. ID NO:1257) TCT TOO CTT TCT TCT CCT TCO GGC CCT COG 0CC GOT OCT TOT GG-31R(FR.AG.NO:1249)(SEQ.ID NO:12S8) CCT CCC 000 COO CCT CCC COO OCO 000 OCT TCT TO-3D (FRAG. NO:1250) (SEQ.ID NO:1259) 5Di-GCO CTOOCO 000 000CCT CCT CC-3D (FRAG. NO:1251) (SEQ. ID NO:1260) CTGTOOGCTGGGCGOTT CCT TOOGTOTTCTG000TOOGC-3D (FRAG. NO:1252) (SEQ. ID NO:1261) COO OCOTOG TOOCCT CT TOG TOO-3D (FRAG. NO:1253) (SEQ. ID NO:1262) CCC O-CO OCT GCB 000 0-3D (FRAG. NO:1254) (SEQ. ID NO:1263) CCT OTC TOC TUC OTC-3@ (FRAG. NO:1255) (SEQ. ID NO:1264) 5D-CTT TG OCT CCC 000 CCO CC-3D (FRAG. NO:1256) (SEQ. ID NO:1265) 5'-000 OTO GOT AGO CCO TOT CTO 000-3' (FRAG. NO:1257) (SEQ. ID NO:1266) S'-OTT GOC CAT OTT GOT TOC C-3' (FRAG. NO:1258) (SEQ. ID NO:1267) 5'-000 CCC OCO OCT OCA 000 0-3' (FRAG. NO:1259) (SEQ. ID NO:1268) Human Fibronectin* Antisense Oligonucleotide Fragments 5'-COO TflT CCT TUG COO TC TUO OCC COG OCT CCO GOT 0 CCC 0CC COC CCO CCG 0-CC 0CC OC CCC 0CC 000 CTO TCC CCO CCC COC CCC GOC CCG, 000 COC 00000O COO CCC TCC COC CCC TCT 000GCC GOC OCO OOC OTC GO CCO CTC OCO CCT 000 OTT CCC TCT CCT CCC CCT OTO C 0CC TOC CTC TUrG CTC TTCTOC GTC COC TOC CTY CTC CC CTC TCC TCO 0CC OTT 0CC TOT GC TOT CCO TCC TOT COC CCT TCC OTO OTO C TOT TOT CTC TTC TOC CCT C GOT OTO CTO OTO CTG OTO OTO OTO CCT CTO CCC OTO CTC OCCCTG CCT 000 CTO 0CC TCT TCO GOT OTO OCT T-rO GOG CTC TCT TOG TUG CCC Tf- CTT CTC OTO GTO CCT CTC CTC CCT 234 GGC UTG GTC GT TGT CTG GGG TOO TGC TCG TCT CCC UTT CCC TGC TOG CCG mrT GT CCT GUT TTC TOT CUr CCT CT UTC CTC CTG UTT CTC CGT UTG GCT TGC TG UTG CGG GGC TOT CTC C CUr GCC CCT GTG GOC T CCC TGG TCC GGT CUT CTC CUT GGG GOT C GCC CUT CU GOT GOG CTGGCT COT CTG TCT UTT TCC UTC C TGG GGG TGG CCO UTG TOO GCG OTG TGO TCG GCC T TOC CTC TG TOG TCT TTC-3' (FRAG. NO: 1828) (SEQ. ID NO: 1841) 5'-OGCCGOGC-3- (FRAG. NO:1829) (SEQ. ID NO: 1842) 5'-GGCGGCGCGGOCG-3' (FRAG. NO:1830) (SEQ. ID NO:1843) 5S-GCCTGOGTOOCC-3' (FRAG. NO:1831) (SEQ. ID NO: 1844) S'-GOGGG TGGCCG-3' (FRAG. NO: 1832) (SEQ. ID NO: 1845) 5'-OO 000 TOO CCO U-G TOG OCO 0-3' (FRAG. NO:1833) (SEQ. ID NO: 1846) (FRAG. NO:1260)(SEQ. ID NO:1269) SD-UOG 0CC COO OCT CG GOT 0-3D (FRAG. NO:1261)(SEQ. ID NO:1270) SDi-CCC 0CC CG CG CG 0CC 0CC GC-31i (FRAG. NO:1262)(SEQ. ID NO:1271) 0CC 000 CTG TCC CGO CCC CG GGG-30 (FRAG. NO:1263)(SEQ. ID NO:1272) 5D-GGC C GGG0 CG 000 GO-30 (FRAG. NO:1264)(SEQ. ID NO:1273) CCC TCC CG CCC TGT 00-3D (FRAG. NO:1265)(SEQ. ID NO:1274) GOC OCO GG OTC GO-3D (FRAG. NO:1266)(SEQ. ID NO:1275) CTCGOCO CGT GO OTT CCC TCT CCT CCC CCT OTO C-3DFa (FRAG. NO:1267)(SEQ. ID NO:1276) 51]-GC TG GT TG C GTT C-3D (FRAG. NO:1268)(SEQ. ID NO:1277) SD]-TOG OT CG TG CUT GTG CC-3Di (FRAG. NO:1269)(SEQ. ID NO:1278) DGTC TCG TCO 0CC OTT 0CC TOT OC-3Dii (FRAG. NO: 1270)(SEQ. ID NO: 1279) CG TCG TOT CG CCT TCCGOTO OTO C-3D0 (FRAG. NO: 1271)(SE Q. ID NO: 1280) SD-TOT TOT GTG UGC TG CGT C-3D (FRAG. NO:1272)(SEQ. ID NO:1281) SD-GOT OTO CTO OTO CTO OTO OTO GTG-31i (FRAG. NO:1273)(SEQ. ID NO:1282) 5D-CGT CG CCC OTO CTCG0CC-3D (FRAG. NO:1274)(SEQ. ID NO:1283) GGT 000 CTO 0CC TGT TCO GOT-3D (FRAG. NO:1275)(SEQ. ID NO:1284) OCT UTG 000 CTC TGT TOO TTG CCC UT-3D (FRAG. NO:1276)(SEQ. ID NO:1285) SD-CUT CTC OTO OTO GCT GTG CTG CGT GOC TTO OTC OT-3D (FRAG. NO:1277)(SEQ. ID NO:I286) TOT CTG 000 TOO TG TGC TCT CCC-31i (FRAG. NO:1278)(SEQ. ID NO:1287) SD-T CCC TG TOO CG UTT GT-30 (FRAG. NO:1279)(SEQ. ID NO:I288) GUT UC TOT CUT GCT CT-3D (FRAG. NO:1280)(SEQ. ID NO:1289) CTC CG T T GTC COT-3D (FRAG. NO:1281)(SEQ. ID NO:1290) OCT TG TG UTG COO GOC TOT CTC C-3D (FRAG. NO:1282)(SEQ. ID NO:1291) 0GCC CCT OTG GOC UTT CCC-31i (FRAG. NO:1283)(SEQ. ID NO:1292) 5D-TOO TCCGOGT CUT GTC CUT 000 OOT C-3D (FRAG. NO:1284)(SEQ. ID NO:1293) CUT CUT GOT 000 CTO-3D (FRAG. NO:1285)(SEQ. ID NO:1294) SD-OCT COTCTO TCTT TTGG UC -3Di (FRAG. NO:1286)(SEQ. ID NO:1295) SD-TOO 000TGGCGTTO TOO OCO TO TOOTCC 0CC T-3D (FRAG. NO:1287)(SEQ. ID NO:1 296) SDi-TOGC TC TG TOG TCT TTC-3D (FRAG. NO:1288)(SEQ. ID NO:1297) Human Interleukin-1 (IL-i) Nucleic Acid and antisense Oligocnucleotide Fragments GGTAOTCTOO TOCTAGAGUT ACAUOGCTTA GATCCAAGTG TOOUTATG TGTOOCTCGT

GTTATAACTA

U'GGAGCTOC

TAGTATCC

GATGOOGCT

GTCGTGAATA

OGCTTAAACT

OCTGOCCAGA

GATATOTAAA

GGCCUTACOC

CAGAAGACCA

TCTGTGGTGA

CTTO

CTGAGOTOAT

U-GGCAGOAO

CTACAGCTAG

GACGAUTTCT

TOTGATCTTA

AATAATATGA

AACTGAAUTC

GACAAUTAGA

GOGTUOAOT

CTrOCTOT

GTOGTAT

TTATAGCACC

AATAOACCUT

AACTGAGACA

TGACTATOTT

GCTGOACTA

CCAACGOOA

GOAATTATAA

AATCCATOCC

ATACCTGCG

GOCUCTCTC

AGCTGCATCC

CTCAAATACG

TTATGCCUTA

CTGCCAAGTA

TAU7AGAACT

CCCTC

TAAAGCAAAG

GCTATGGAT

TTCCCTGTAA

AOOTCTATOA CCAOGAGAAT TAGACTOOCA UTAAATCAGA ATAAGAOATT ATOACAGCTA ACGAACGGCA TTATTTACAA TTAAACAOOA AAGAAOGAA

AOCTOUUTC

GCGCACACTO

CGOGGGCATC

ACCCAAAACA

AAGTGAAA

U7CCTU'CTC

GOOCUOGCAG

TOOTCCTTG

CCTCTATAGG

ACTGTUCTCT

ATGAAGCAAA

UTCTGCGAAT

AUTATTAUTA

TAOAAACUTG

GOGTGAATAA

CTCACTAT

AUGCGGTT

GTCGGAOATC GATOCTT1TTT OAGTAAAACT GTGOOCGTCA GCATGAGACC TAOTTCAT U TCATTTGCT

AUTCTTAAT

CGAATCTGCA

ACACGUGUT

TAOAOOOGTA

AAATGTGU7G

TGTCTAGCCT

GTTCGGTCUr

TGAGGGA

ATAAATTCCT

ATAAGTTTCC

ATGAACCAAA

UTAOCCAGT

UTGAGGACGC

AAGAGTCTGO

AATAOTAACG

TTCCGAAACT

CTACAOAAGA

TOCGTATT

AGTOAUOGTC

CGTCTAU'TA

TOUTCTAGGA

AGGCAACATG

TAOCCACTOG

CACACCTUGG

ATTUTTAGA

CTGCCTCAGC

AAATATAGAT

CCTGAACTAG

ATTGAAGGCT

TUCTGGCTOA

GCATATCCTA

GUTACTOTA ACAGOOCCAG GGTOOAGAGT kCAATAT-CA GAAGAOTAAO AGGATCAAGA GCCCTAAGCA GGAGCUTGTC AGGCCAAAGT CAGAAAAGAT GGCTCAUUT- CCCTGAAAAG GCACAATCAA CAAAUTCAGC CAOAACACAA CTCCAAATCT AOCCGGUFGA CUTGGAT GGCGCUGCCC TUCTAAO ACTAGATOUT TCAATAACTT CTOOAATATG TGCAAAGAAC kTCGAGUTGA ATOAAGATAG AAAAATAGAA ACTTGTAGCG ACOTAGGAC GGGTACUTAA CTGCGAGCCA OAOAGGGAGT GATUCAUTG TAUTAAAOTA YTFG7TGTTO TTGTTTrCT AOTGTCTCCT UTT=TGU GTGGGTCGCT AATGAUTCTG TCATTOCT GATAAGGACT AAAOOCGAAG AAOACGAGT GAOGUTAAG CGCAAAGGT AUTGTGTA CATCTCGGC UTTCTGTCAG AU-GCCTTGT GTAAAGCTAG OTOACCTAOA AUTAGAGTCA GAUTTCGAA 235 GATTCGTTFF ACTGAGGGAC GGCAGAACTA CATGGGAGGG AATCTCTACT ATCCAAAATT TACCTCTGTG TAAGGCAAAT ACCTTATTCT ATGCCTGTTC TGGCAATACA TTAGGTTGGG AGTTTACGAT CTAATAAAGG AGACAGGTAC GTTI7CCTATG AGGGCATGGG TGAATACAAC TGAGGCTITCT A~rAGGAGAA

TGTGGTGTT

CACATAAGGA

ATAGCAAACT

YITTTCAGGAA

TGGCTGGTGT

GUTACAGGTA

AATrGAAAAT T1TCCAACTCT TTGTAACCTC TTCAAACTrT ATACCAACAT AAATAAAACA AATFCAAAGG AGCTAGAAGA GCACAAAGAG GAGGGGCTCC TCTCTGTTGC AGAAGTCAAG AGGAATAAGA TTTATCTCTT GCTGAATGTG GACTAAGTCA ATCTGGATTA GAGGCTGGCT TTCCAGACAT GT[FTGAAGAC GAGGGTTTCA AGGCTCACCA YI7GTAGAGAT GTGTACTAGT CATGTTAAAC TGAGATTACA CCCTACATGA ATATCAGCAT GTTIFTACTGG TCCATTCTCA GCATGTGAAC TCACATATGC AATTACGGAA CATATTAAAC TCAAAATTTT GCCTGGATAT TGTGTAACAT ATAATCTATr GC'rrAACATrr CTTCCCTGAA AAGCACAGGT AAAGCTCAA) ACCTATGTGT ATGTGTAGAA CACAACTATC ATGGTCATTA ATC'rrArrr GACAGTGAAA AAATGACTGT AATTCTCATG ACTTGAATCT TAAATACTTT ACCAGCTGCC TCTCTAAACT ATCCCTGAGA ACTGGAGTCT CGCAGGCCGC TfCACCAGGT CAGAGOTTAG AGAAAGTCTC TACAGCCACT CATCAATCTG TGTCTTCAGT ACTGGCTTA AGATTT[TAA CCTCCTGAGA AGTTACAACA TCTCATTTTT CTGGAAGGAG GAAGGAAGGI AGACCAGAAT GGAGATCCT( GACCATGAAC AGCCTCTCAC CACTCCATGA AGGCTGCATG TACCTTCAAG GAGAGCATGG AGCCAATCCA TCACTGATGA CAATAATATC TTTCTTTTAC GTCAGAATAA CAAGAAGAC) CTCCAGGAGG GAGAAATGAC ATTGTAAAGG TCGTGTGACT CTCTCATACT AACTATGCCT AATGGAGATA ATCAGAATCC GAGCTAGCTG GGCCCTCCTG TAATGTCTGG TACAAAGTAA 'rrTTTrTTTG AGATGGAGTC AAGCTCTGCC TCCTGGGTTFC CGCCACTG17 CCCGGCTAAT GTGATCCACC CACCTTGGCC TATTATTATT ACTACTACTA TGTCTAAACC TCACAAGAAT AACTGCCCAA TGGCATACAT ATCATGGTT CTCCTCCATC TJ7AAGATAAT ACCTAAGCAA TAAAAATCAC TCATATCGTC GCTATACACA TACCTACATG AGCTTTTCTT AC1TAGCAAT ACAATGAACA TCTGTATAAA GTAGAATC CCAGAGCCAT ATATAATTAT TT11TAATGCA TGGTAGTCTT CCT-rGTCAGT AAAACAATGA AACTATTGCC CTAGAAAACC AGTrCTGCTG TAATACCCCC TCCAGAACTA CATTAATCTG CACTTGTGAT GCAATGTGAA ATACAACYT TrCAACAAAG

GAGCTGATGG

CTGAAGAACT

GAATCCAGCT AGGCATAACA CCTGAAGTCA GAGCAGGTTC TTGGCAGGGA GACCGCCATT CAACTTAGAC ACAGCCTCTG GGAAAACTTG ATCTCATTCA AGGCAAATCT CACTCAGATG TAACATGATG TYITCCATTAT

M~ACTAAGT

TGGTTAAAAT

CYITCAAT-rAA k GCCTGTCT[G

GTCCTTAAAT

AAGTACATTG

ATGAAGAAGA

GGACTGCTAT

TGTTACCC

AATAGrITGAT

CCTGGGGCAG

GTCTGTCTCC

CAAACATGAA

TGTTATTGTG

AAAGCTGTCC

GGGAACTAAT

GAGCATGCAA

ATAAATTATG

AAAAAGGAAG

AGCTCTTCAA

ATGACTACTA

TTCAAAGATG

GCCAGAGACC

CAGTTCCTCC

TC'FrACACAG

TCACTAGAGA

GTGCAT"fGGC

GCTITCATCAG

TAACGTGATG

GCTGAGAGAG

TTTGGAGACC

CCAAAGGAGT

TGGAAAGCTA

ATAAATGAAA

GTGGCCAGCA TGGGGGCAGG AGAGAAGACC CAGAAAAACT TT7AGAAAAAT TATTTTTGAG 1TGAGATCAC ATGCCCTGAT GGAACAGGAA ATGGCTCCAC TAGAAGAAAG GTAAATGAAC CTGTAGTAAA TACTAACACA AAATCTGTTr TAGTGAATAC TGCTTCAAAA CCTCTfTTT TTT7GTTAGCC AAGTCCAATT ATTCCAGATT AGTAAGATAT ACAGTAATGG CCATGTGTAT ACATGAAATA ACAACAATTA A11TGATCATC TGTCTCTGAA TGGMTfC ATCCAAAGAG TCCAGAGACC TGTCTCAT TTCTCCCAGA ACAGAGCAGA

GTCTCTCTCT

CATTGATTGA

TITCTAAAAGA

TGGAGAAAAT

CCTCACAGAT

ATGGCCAAAG

GTGATTTAAT

CCGGCAGAGG

AAGCATTCAG

GTCTGCTGAG

ATAAGAATGG

AGCAAGCTGG

ACAAAGATAA

AACTAGGCTG

ATGAAAGTAA

CTCTAAAGGA

TTTACAGATA

GAA17ACTCT

GTGTGTGACC

CATTCTCATC

TCAGGTAAGC

AACAGCAATG

TATAAGTGAG

ACTATCCCAA

GATGTTAGTT ATGCCATCCT GAGAAAGCCC TGTTGTGGTT GTCTTCTCTG ACACCAGCAT AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC ACAAATAGAC ACTATAAGTA CTGCCTAGTA ATTJTCTAAAA TATITTTGAGC ATTGTTAAGC CCACTCACTA CAATCATTGT TAACCTATTT AAGTCTTFCCT AAAAAAATCA TCTTTrTATC AGGGAAGCCT AATGAAACAC CAGTTACCTA CAGCACCTAC TGAAAGAACT TTCAT-rCCCT AGAAATCCTT CTATCATGTA AGCTATGGCC TATCTCTGAA ACCTCTAAAA CATCCAAGCT AAGGTTCTGA AGAAGAGACG GTTGAGTTTA GAGACAAAAG GGAGAGAGGG CTCACTACCT CTGTTGAATA CTTCTGTT CCTI'CCTCAC GATCAATCTG TGTCTCTGAG TGGTAGTAGC AACCAACGGG TGACCTGGAG GCCATCGCCA ATGACTCAGA GGAAGGTAAG GGGTCAAGCA AGTTTTAAGC AAGTAGGGAC AGTAGAATTT AGGGGAAAAT TAAACGTGGA SACCAAGCATT AGTCTGGTAA CTATACAGAG GAAAATTAAT TT17ATCCTT 3CAGTGGCCTG AATCGAGAAT ACTTGCTCAC AGCCATTATT TCTTAGCCAT TTAGCCTTT CAGGAGAAAG CCT-rGGTCAT GTTACATAAT CCCACTCATT GGATTGT-rGT ACTGTTATAA AGATTAAATG GCACCCAATA AATGTTAGC CAGTAATAAG ACCACTI'ACG CT]TCGTGA TTCAGTTTCC AAAGATTAAG AGTCTCAGGC AGTCAACATC CCCTAACTTC r ATTACTATCA TTAYI7ATITAT GAGTGCAGTG GCACAATCTC CCTCCCGAGT AAGCTGGGAA

AGCTATGTTC

TCTACTGTAA

TTTACAGACT

TGGACTAGAA

TATTATTT

GGCTCACTGC

TACAGGCACC

TGGCTCTGTC

ATGCCATTCT

1TTGTATT

TCCCAAAGTG

CTACCTATAT

CCTACCYJ7CT

CTGTAAGTGG

CCTITFACTGT

TAACGCATGT

AGTGAGAGTT

TGAACAAATA

GTATTGAGGA

ALCCCAGGCTG

CCTGCCTCAG

TTTAGTAGAG

CCGGGATTAC

GAATACTACC

CATfT7ACAT

GAGAGCCTCA

ACAAGCCTCC

TCACCTAGAA

TACTACTGCC

TGTCTAACAT

CATiTTAGAG

ACGGAGTTTC

AGGCGTGAGC

AGCAATACTA

AAAAGGAAAC

AATCTAAT-rC

ACATGAACTA

GGMTTAAAA

ACCGTGGTCT CCATCTCCTC CACCGCGCCC GGCCTATTAT ATTTAT7AAT GACTGGATTA TAAGCTCATT GAGATAGGTA AGTTCTACCT GAGTAAAAAA TAAACCCAAT AYITCCTGTTT TGTAACAAAA TATAAGAAAA AGCACTATGG TATGYITTCCT CAAGACCACA CTATTTACAA TGCCCGTMT TCACCATTAT CC'TFrATC CTlAGAATAT ATATGTGCCA CTTTGCACTC

TAAAATCTTT

CTTrTATATCC

AAGCAATGCA

ATTFCCTAGAA

TCTGTGACAT

*TAAATA'I1CA 1TrTCTCTCAC GAGGATGT GACGCTATTG TTCATTTT TCTCAGAGTG TAGAAACACC CAAACAATGA TGAGGAATTG AAGTTrAAAA ACTGGGTGAT TITCACTTCTC T=TCCCTGT TTlGTACTAGA CATGGTMTA GAAATCATCA ATGAGGATCA TCAAATACGA 236 CATTCGTTTG AAAACATAGA CGGGAAATAC AAAATGAAAA AGTITGCACAA ATAGTCTCTA AGAAGCACAT AAGCAACAAC AAGGATAATC TTTGCTTCCT CATCTGGATT GGAATATTCC CTGTGTATAT CATCTGTGTU TGTACATAGA AGCCTAGGTC ATCACCTTUFT AGCTTCCTGA ATTCATCCTG AATGACGCCC TCAATCAAAG TATAATfTCGA GCCAATGATC AGTACCTCAC GGCTGCTGCA TACATAATC TGGATGAAGC AAATGGCACC AGACATTTCT GTCATCCTCC CCTCCTrCA TTTAGTTATT TATTTATTTC CTTGCAAAAA ACATACCTCT TCAGAGTTCT GGGTTGCACA ATTCTrCCAG AATAGCTTGA CCCCATAAAA ATCCCAAGCC AGGGCAGAAG GTTCAACTAA ATCTGGAAGT TCCACAAGAG TATCTTTGAG AGTAAAGGGT TGTGCACAAA GCTAGCTGAT GTACTACCTC TTTGGTTCTT TITACCCTCAA 'TfTAAAACT GAGGAAACTG TCAGACATAT TAAATGATTT ACTCAGATTT CAATGAAGAA CAATCACTCT CCTT-rAAAAA GTCTGTTGAT CAAACTCACA AGTAACACCA ATCTTTATTA TCTCTGATAA CATATTTGTG AGGCAAAACC TCCAATAAGC TACAAATATG TGAAGTTrAG TGTCCAAAAA CTTTTATCAC ACACATCCAA TTTTCATGGC GGACATGMT AGTATACATA TTTTCAAAGG TCCAGAGAGG CAATTTTGCA ATAAACAAGC AAGACTTTTT GCACTTCAGC TAACATGCTT TCAACTCTAC AYFTACAAAT TATTI'TGTGT TCTA1TrTC TATTTCTGCA ATTTTCCCAA TATTGACATC GTGTATGTAT 17GCCATTTT TAATATCACT ATCAGGTITGC TACG'FrGGTC CCTTGGGTTT ACTCTAAATA GCTTGATTGC AAATATCTTT TTGTTTTrTC TCCTATCTrG TAATTTCT-rT GAGCACATCC CAAAGAGGAA TGCCTAGATC AATAAT'FrGA CAGCTCTTAT TAAACATTAT TCTGTAAGTA AAAACTGAAC TACTTTTCAG AACATATGAG TGTATCAGCT TCCTAAACCC CTCCATGTTA GGTCATTATG AACTrATGAT ACAGGGTCTT ATCCCACTAA TGAAATTATA AGAGATTCAA CACYFATTCA GCCCCGAAGG CGTAGAAAAT TCTAAGAACA UTAACCAAGT ATYI'ACCTGC CTAGTGAGTG TGGAAGACAT ACAAAGATGT ATAGAATTCC ATTCCTGACT TCCAGGTATT TACACCATAG GTGGGGACCT ACACACACAC ACACACACAC ACACACACAC ACCATGCACA CACAATCTAC ATCAACACTT AAATACAATG AATTTACTTT CTrTT[GGTT CTTCTCTTCA CCAGTGAAAT TTGACATGGG TCATCAAAGG ATGATGCTAA AATTACCGTG ATTCTAAGAA TCTCAAAAAC TCAATTGTAT AAGATGAAGA CCAACCAGTG CTGCTGAAGG TCAGTTGTCC TTTGTCTCCA ACTTACCTTC CATATGTTTG TAAATAAGCC CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTCTT CACAGCCCCC ACCTACCCAC CCCACTCCCA U-GATTCCAG AGGCGTGCCT AGGCAGGATC TATAACAGAG AGTAAGAGGA AAATTACCTr CTTTCTTTTT CCTYITCCCTG CCTGACCTTrA ATCCCAGAGC ATCCATrTAT TCCATTGATC 1TACTGACA TCTATTATCT GACCTACACA TTAGGACAAT GTGGCCTGCC TCCAAGAAAC TCAAATAAGC CAACTGAGAT CAGAGAGGAT

AGGTACATTA

AATCTTCTG

AGCACAGCAC

AGAAGTTTCC

TCAGACATTC

ACCCAGAAGC

AACCAGGAAG

GCTTAAAGGA

TAGTTTCAAC

CTGATTGGAT

TACTTAATAT

AGACAAT1TCA

GTATATATTA

AATGGGCACA

TATCACTAGC

CTAACAAATT

ATTCATTCAA

TGTGAAGGAC

AACTACACAC

GATTTTATAC

TGCTTATAAG

GTGACTGCCC

ATTTACATCT

TCCTTCCTAC

TATGAGAAAA

TTCACCTCCC

ATACTAGACA

TAATCACCTG

CCAATGGGCA CAAAGCAACA CTCTGCAY[G ATGTCAGCAT CACACACACA ACAGCCTTAG AAGACCTTCT AYFCCCAAGT CAGAGTAGGG CAGTAGCTTC CAGGCATAGT GCCAACAGCA TGGAGGATAT GGAAAACAGA GAATAGGGTG CTAAGATAGA GTGAGATGAG AGCTGCCGAC GGGGCGGGTC GTGGTTGTGG TTGGGTAGGA CATTCAGAGG GGCGGGTCGT GGTTGTGGGT ATGGTAAAGG ACAGCTCCAA ATATGCAGAG ACTAGTGCTT GGGTTTCACA CAGTGCAATG AGCTGGGAGC CAAGTCCCAA AATGGGGCCT GCTGCTTCCA GTTCCCCTCT TATCCTTCGT CCCAGTCCTG TCTCCACTAC CACTI'CCCC CTCAAACACA ATGTTTTCTC CACTGATAAG TAGGTGACTC AATrTGTAAG TATATAATCC AGAATITATG TGCCTGCCTG TGC'I[CTA CCTGGATCAA GTGATGTCTA ATTCATGAAC TCATTCAACA AGCATTA1TC ACTGAGAGCC 'TGTATTTTT GTGTGGACAG TGGTGCATCA AAGCCTCTAG TCTCATAGAA CTTAGTCTTC CAACCCAAAC AACCAACAAA AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT GAAAAGTGGG AGAGTGCTAT TTAGACAAAG TGGTAAAAAC AAAGCCCCT-r AGAGGGGGCG GGTCATGGTT GTGGGTTTIT GGGTAGGACA TTCAGAGGAG GTTTTTGGGT AGGACATTCA GAGGAGGGGG CGGGTCGTGG TTGTGGGTTT AGGGGGCGGG TCGTGGTTGT GGG1TrTTGG GTAGGACATT CAGAGGAGGG TMGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA CAACTrCAAG GGATCAGAAG AAGCATTCTT GGAACTGGGG CA'TrTGAGA AGGAGGAAAA GCAGAGCTTG CAYFTGGATT TCAITGAGG TACAATGAAA ACCCATTAAT GCCTGACCTC ACTJ7ATATTT CCTAAAATAG AAAACAGATC AGAAGGAAGG CAATAGAGAA GCAGAAAGTC CAATGAGGAG GTTrCACAGC AGTCATGGGG GTGGGGTAAG GAAAAGAAGT GGAAAGAAAC AGACAGAAT[ GGGTTATATT YUGGAGATAG AACCAACAGA AGGAAGAGGA GAAACAACAT TrACTGAGAA GGGAAAAAGT AGGAGAGGAA TAGGTTTGGG AAATAAATCC TGCTGACATT GGAAACCCCA AGGAAGCCTC AAAAGTATAT TrACTTGCTT TAGA'TrAAA AGAATAGGAA AGAAGCATCT CAACTITGGAA 'FrTGAAATCT ATTfTCCAT AAAAGTATTG TTAAATTCTA CTCATACTCA CAAGAAAAGT ACATTCTAAA GAGTATATTG AAAGAGTA CTGATATACT TAGGAATTTT GTGTGTATGT GTGTGTGTGT ATGTGTGTGT GTGTG1TUAA ccTFrCAATTG TTGACTTAAA TACTGAGATA AATGTCATCT AAATGCTAAA TTGA1TCCC AAAGGTATGA TT-FGTTCACT TGGAGATCAA AATGTTTAGG GGGCTTAGAA TCACTGTAGT GCTCAGATTT GATGCAAAAT GTCTrAGGCC TATGT7GAAG OCAGGACAGA AACAATGTTr CCCTCCTACC TGCCTGGATA CAGTAAGATA CTAGTGTCAC TGACAATCTT CATAACTAAT TTAGATCTCT CTCCAATCAA CTAAGGAAAT CAACTCTTAT TAATAGACTG GGCCACACAT CTACTAGGCA TGTAATAAAT GC17GCTGAA TGAACAAATG AATGAAGAGC CTATAGCATC ATGUTACAGC CATAGTCCTA AAGTGGTGTT TCTCATGAAG GCCAAATGCT AAGGGATTGA GCTrCAGTCC ITITTTCTAAC ATCTTGTTCT CTAACAGAAT TCTCTTCTT[ TCTTCATAGG AGATGCCTGA GATACCCAAA ACCATCACAG GTAGTGAGAC CAACCTCCTC TTCTTCTGGG AAACTCACGG CACTAAGAAC TATTrCACAT CAGTITGCCCA TCCAAACTTG TTTATTGCCA CAAAGCAAGA CTACTGGGTG TGCTTGGCAG GGGGGCCACC CTCTATCACT GACTTTCAGA TACTGGAAAA CCAGGCGTAG GTCTGGAGTC TCAcTTrGTCT CAC'FrGTGCA GTGTI1GACAG TrCATATGTA CCATGTACAT GAAGAAGCTA AATCCT-rTAC TGYrAGTCAT TTGCTGAGCA TGTACTGAGC CTTGTAATTC TAAATGAATG TI7TACACTCT TITGTAAGAGT GGAACCAACA CTAACATATA ATG'rrGTTAT TTAAAGAACA CCCTATAMT TGCATAGTAC CAATCATTTr AATTATTATT CTTCATAACA AYITTAGGAG GACCAGAGCT ACTGACTATG CATATTACAG ATGGGCAAAT TAAGGCATAA GAAAACTAAG AAATATGCAC GCCACAGACC TAGGjA~rTCA TGATCAT-r TCAACTGTTT GCCTTCTGCT TTAATCAAAT AGCATAAGTT TCTGGGACCT CAGTTTTATC ATTTTCAAAA CCU-CCTGCC GCAACAGTTr TT[ATGCTAA TCAGGGAGGT CATnMGGTA 237

GCTACCAAAA

AATAGCAGTT

7I1TAAGTTGC

TGGAGGGAAT

AAATACTTCT

AGACTCTACC

GAAACAAGAA

TGATGAACTC

AATACCTAAG

CGAAGCCGAG

CCTCAAGATG AAGGCAAAGC ACGAAATGUT ATYITTTAAT TATTATTTAT ATATGTATTT ATAAATATAT TJTAAGATAAT TATAATATAC TATATTTATG GGAACCCCTT CATCCTCTGA GTGTGACCAG GCATCCTCCA CAATAGCAGA CAGTGYT TIC TGGGATAAGT AAGTITGATT TCATTAATAC AGGGCATTTrT GGTCCAAGTT GTGCTTATCC CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT GTAATCATAT AATAAATGTA CATTAATTAC CTTGAGCCAG TAA11TGGTCC GATCTTTGAC TCTTGCCA TTAAACTTfAC CTGGGCATTC TTGTTTCATT CAATTCCACC TGCAATCAAG TCCTACAAGC TAAAATTAGA TGAACTCAAC YITTGACAACC ATGAGACCAC TGTTATCAAA ACTT-rCTTTT CTGGAATGTA ATCAATGTTT CTTCTAGGTT CTAAAAATTG TGATCAGACC ATAATGTTAC ATTATTATCA ACAATAGTGA ITGATAGAGT GTTATCAGTC ATAACTAAAT AAAGCTTrGCA ACAAAATTCT CTGACACATA GTTATTCATT GCCTTAATCA TTAUTTTACT GCATGGTAAT TAGGGACAAA TGGTAAATGT U-ACATAAAT AATTGTATTrT AGTGTTACTT TATAAAATCA AACCAAGATT TTATATT111T TFCTCCTCTT TGUTAGCTGC CAGTATGCAT AAATGGCATT AAGAATGATA ATAT117CCGG GTTCACTTAA AGGICATATI ACACATACAC AAAACATGTG TTCCCATCTT TATACAAACT CACACATACA GAGCTACATT AAAAACAACT AATAGGCCAG GCACGGTGGC TCAGACCTGT AATCCCAGCA CTrTGGGAGG ACCAACCTCT TCGAGGCACA AGGCACAACA GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCATTGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TGAGCTCGCC AGTGAAATGA TGGCTrATrA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTJTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CTI'CATCTTr GAAGAAGAAC CTATCTTC17 CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGFTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TrJACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGT7CCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTFrTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCCAGCC C1TIGTTGA GCCAGGCCTC TCTCACCTCT CCTACTCACT TAAAGCCCGC CTGACAGAAA CCACGGCCAC ATTTGGTTCT AAGAAACCCT CTGTCATTCG CTCCCACATT CTGATGAGCA ACCGCTTCCC TATTTATTTA TTTATTYFGTT TG17TGTTUT ATITCAUTGGT CTAATTFFATr CAAAGGGGGC AAGAAGTAGC AGTGTCTGTA AAAGAGCCTA GTTTTTAATA GCTATGGAAT CAATTCAATT TGGACTGGTG TGCTCTCTTT AAATCAAGTC CTTFAATTAA GACTGAAAAT ATATAAGCTC AGAFITATliTA AATGGGAATA TTTATAAATG AGCAAATATC ATACTGTfCA ATGGTTCTGA AATAAACTTC TCTGAAG AGAAAGAAAG AGAGAGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGAAGG AAGAAAGACA GGCTCTGAGG AAGGTGGCAG TTCCTACAAC GGGAGAACCA GTGGTTAATT TGCAAAGTGG ATCCTGTGGA GCAGGCCAGA CACCAAAfT AACTAACATG TTGAACAGCT CTGACTCCTG ATATCAAGAT AAATGCTCTTr TTTCCCACAG TUGGATAATG CAGAGCGAGC CACCCATTCA AGCAGCAAAC AAAGATTTCA GITTCCTGGA CTGGACACGG TGGCTCACGC AGATCGAGAC CATCCTGGCT UTGGCGGCAG GTGCCTGTAG CGGAACTTGC AGGGGGCCGA GGCANNCAGA GGAGTCCCCT AGGCCACCCA GACAGGGC'rr TITAGCTATCT CAGGAGGGCT CAGTGT-rAGG AATGGATTAT Y7TAGATTTC CTGTGGAAAA TATAACYFAC ACTGGGAGCC AAATTAAAAA TCAGAAGGCT TAGAACCTAT TTCCCTCGTG TCTCAAATAC ACGATACCTG GCACATACTA ATTTGAATAA TCTATCTCAC CTGAATGTAC ATGCCAGGCA GGAACCAGGA GGGCAAGGTT TCAACTCAGT CTGTAATCCC AACAT1TGGG AGGCCGAGGC AACATGGTGA AACCCTGTCT CTACTAAAAA TCCCAGCTGC TGGGGAGGCT GAGGCAGGAG GATCGTGCCA CTGCACTCCA GCCTGGGCGA GGCTTATCAA ATTCACAGGA TAAAGATGGA GTTCTJTGTGA GCTTGGAGAG CAAGTCCATG TTGCACAGAG GCTCACTCCC AATGCTGTCA AATTCCCATr CTGTGCTAGA CTrGGCTCAA GCTATAAGAA GTGYTACAGG GGGCAGATCA CAAGGTCAGG TACAAAAAAT TAGCCGGGCG AATGGTGTGA ACCCGGGAGG CAGAGTGAGA CTCTGTCTCA AAAAAAAAAA AAAAGTGTTA TGATGCAGAC CTGTCAAAGA GGCAAAGGAG GGTGTTCCTA CACTCCAGGC

ACTGTTCATA

CACTTrGCTG

GGATATTCTT

CTGGCATTGA

C7I1TATCTCCA

CAAGAAAGGT

CCAAGGTAGA

ATCTGTAAGT

ATCTGTGTGT

AT1TIAATGT

GCAAAATGTG

CCTCCCCTAA

AACAGAGAAA

GATACCAAAC

CTCAAGTATG

GTGTATGCAT

CTCAGCT'TFT

CTGCT~rATCT ACCTGGACTC TCATTCATTC TACAAATGGA GGGCTCCCCT GGGCAGATCC CTGGAGCAGG GTGTCTCGGT TAAAGAGAAA CTGATAACTC TTrGGTATTAC CAAGAGATAG AGTCTCAGAT ACAGAAACAA TATTCCCACT TTTCAGAGTT CACCAAAAAA TCATTTTAGG CAGAGGICAT TCTGGTTCAT CCATGAGA11T GGCTAGGGTA ACAGGACCTG GTCTTGCAGG GTfrGTGTGAG GGGTTGCCCC AACTCCGTCA GGAGCCTGAA CCCTGCATAC CGTATGTTCT CTGCCCCAGC CAATITI1CTC CTCAGAGGCT CCTGCAAT-rG ACAGAGAGGI CCCGAGGCAG AGAACAGCAC GACCCACACC CTCAATACAG ACAGGGAGGG CTATTGGCCC TTCATTGTAC CCATrr7ATCC

GGGAAGATTC

CT-rCCACI1'T

GGACATCAAC

TCATAGTTTG

GAAGCTTCCA

TTTCTCAGCC

CTCTUCGAGG

ACTTTAATCT

A~rCTCTCTC

TGCAAAAATG

AACAGCTGAC

CTAAACT[AA GTACAAAGAA GTGAATGAAG AAAAGTATGT GCATGTATAA GTCCCACATA TACTAAATTT AAACATTCTT CTAACGTGGG AAAATCCAGT TGCACAACGA TTrGTCAGGAA AACAATGCAT AYTGCATGG TGATACATiT CTACTCCTTG CCCTTCCATG AACCAGAGAA ITATCTCAGT TTATTAGTCC CCAATACTCT TTrCCCC'IM CCTTTAACTT GA'rrGTGAAA TCAGGTATTC TCCTACTTCT GCTTTTGAAA GCTATAAAAA CAGCGAGGGA GAAACTGGCA CACAAGGCAC AACAGGCTGC TCTGGGATTC TC'FrCAGCCA ATCTJTCATTrG TCCTFACAAC TAGGTGCTAA OGGAGTCTCT CTGTCTCTCT GCCTCTTTGT TCTCTCTCT'r TCTTTCTCTG TCTCTCCTCT CCTfTCCTCTC TGCCTCCTCT CCAGGTGTAA TATAATGCT[ ATGACTCGGG AAATAT-rCTG GGAATGGATA ACCCTAAAGG TTrAGTGTCAA AGCCTCTGCT CCAGCTCTCC TAGCCAATAC 238 ATTGCTAGTT GGGGTTTGGT TTAGCAAATG CTTTTCTCTA GACCCAAAGG ACTTCTCTTT CACACATTCA 17CATTT ACT CAGAGATCAT TTCTTTGCAT GACTGCCATG CACTGGATGC TGAGAGAAAT CACACATGAA

CGTAGCCGTC

TACCTGAGCT

AGGTCTCCTC

TCAGTGGCAA

TGGGACCTGG

CCAAGCCCAC

CTGACTCTGC

CTAGAATCTG

AGAGGCAGGC

TTAGAAGACA

CTGATGGCCC

GGGAAAGCTC

cTcTrcCAGT

TCACTAACGT

ATAGTAGGAA

CAATCACTTG

TAGAATAGTT

AATTGAGACT

TCATCTGAAA

AATATTY[TCA

GCCATGTTAT

CAGCCTAGCT

TGATAGCCTC

GACTGGCATA

ATTGCCTCTfr

CTTACAGGTC

CTTAATACGG

CAGAATGCCT

GAGTGAGCAT

TAGGGATACA

AGTAGAATCG

GCCTCTACCT

ATTrTA1TT

CCAGGCTGGA

T-rCCTCAGTC

GTAGAGAAGG

GGCTTCCCAA

GCTCGGGATT

GOCAGGACCA

CCCTCTGGAT

TCAGTTGTTG

ACCTGAGCAC

TGTGTCCTCT

AAGGCCCAGC

C1TAAAGAAG

ATTGTCACCA

CTGTTGCTCG

TGTTrcTTAGC

AGGTGTCCTC

ACAACATGTG

GCACCTGTAC

ATGAACTGAA

CCCTGCCTGG

AATGATCAAC

TGAYI7GCACT

AGGACCATGT

TGGACATGGC

TAATGTGTCC

TCCTTrGTAGG

TGCGGTGAAC

GGAGTGTGGG

CCAGGCCAAG

GCTGTGACTG

CCAGTTrC'rr

GCTTCACCTC

ATGGGGAAGT CACTCATFTT CTCCT-rTTTA CACAGGTGTC TGAAGCAGCC ATGGCAGAAG CGCCAGTGAA ATGATGGCTT TTTrCAAGAGT AGAGTGTTAT ACAGGGTGCC AAGTAAATCT

ATTACAGGTC

CTGTGCTTGG

GAM~AAAGA

TGCAAGGGCT

A~GTGGAGACG CTGAGACCAG AGACCAGATT 1TCCCCTAA CTACTTTCCC A11TACAAGTC rCCTGcAGAG GCAAATGGGG

TAACATGAGC

ATTGCCTCTT

CCTCCAGCCT

AGAAAAGATT

AGGCTATCCA GATGTGTTGT AATACAAGGA ATCCCTTrGC AAAGTGTGGC TTGGAGGGAG AGGGAGAGCT CAGATTTTAG TGGGCTAGAG GTTAGGCCTC AAGATCCAAC AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CC'FFCTGGAC TGTTCTGCGC ATATCACTGT GAAACTTGCC AGGTGTTTCA GGCAGCTTTG TGTTTGCAGT 11TCTTATGAA CAGTCAAGTC TTGTACACAG GGAAGGAAAA ATAAACCTGT TAATTGAGAC ATGTCCCTGT TTTI7ATTACA GTGGCAATGA GGATGACTTG T[rC1TTGAAG TAAACAGATG AAGGTAAGAC TATGGGTTTA ACTCCCAACC CAAGGAAGGG CTCTAACACA AAAGAAGGGA GTTCTGGGCC ACTITGATGC CATGGTATTTr TG1TrAGAA AGACTT'TAAC GAGACACAGG CTGCACCACT TGCTGACCTG GCCACTGGT CATCATATCA CCACAGTCAC TGGTGGTGGT GGCCACACTT GGTGGTGACA GGGGAGGAGT AGTGATAATG TTCCCATTrC GACAACCAAG TCTTCAACAT AAATTrGATT ATCCTT17AA GAGATGGATr CAGCCTATGC AGTTAAACTC TGAAACCAAG AGATGATCTT GAGAACTAAC ATATGTCTAC CCCTTTTGAG TTTTGCTACC TGGGGTGAAG CTTATAACAA CAAGACATAG ATGATATAAA CAAAAAGATG

TGAAAGAAAA

AATAAAGGGC

GTTGTAGCTA

ATTCCTGCTG

AGGTCAGTTG

CCA'ITCACTT

TGAGCTGGAT

AGGGCAT'flTG

TCCCTTCTGT

TGCAGGTTGG

GCTGTTTGAC CTTGACAAGT GATCTCTGAG ATTCCAGCAT GGCAGCAAAT GGTCATTrTTT TTTATATGAT GCTCAGTAGC AGGCAGCCAC TMTCTCTGG

CATTTTACCC

CCTGCAACCT

CAGACTCATC

CTTCCTAGGT

CTTTATTTTA

GC'TfTGGACC CCAGTfTCTGA

CTTACAAAGA

GCCCAGCCAT

TTCCAGTTTG

CCCTAGCCTC ATAATCCAGT CCTCAATCTT GTTAAAAACA TATTTCTTTA GAAGTITAA ACTTCTTGGC TGCAGCTGTG GGAGGAGCCC ATTGGCTTGT CTGCCTGGCC TTTGCCCCCC CCAGCAGCTT GGCTCTGCTC CAGGCAGGAA ATTCTCTCCT GCTCAACTTT CTTTTGTGCA TCTTFAACTG TCTTTCAAGC CTGAACCA TTATCAGCCT TAAGGCAACC TCAGTGAAGC AGCTTCTCTG AATAAGAGGA AAGTGGTAAC ATITCACAAA AAGTACTCTC ACAGGATTTG ATGAGACAGT GTTATGAAAA AGGAAAAAAA AGAACAGTGT AGAAAAATTG AATACTTGCT AGGTGAATGG AAAATGTTAT GGTCATCTGC ATGAAAAAGC AAATCATAGT GTGACAGCAT AAAAGATATA GAGAAGGTAT ACATGTATGG TGTAGGTGGG GCATGTACAA AAAGATGACA GGATrTATTC TAAAGAATAG CCTGTAAGGT GTCCAGAAGC CACATTCTAG TCTTGAGTCT GCTGTGTGCC CTFGAGTACA CCCTTAACCT CCYI'GAGCTT CAGAGAGGGA TAATCTT ATFTTA'rrrT GTTFGTT[ GTTTTGTTTT GT1T[-ATGAG ACAGAGTCTC ACTCTGTTGC GTGCAGTGGT ACAATCTTGG CTTACTGCAT CCTCCACCTC CTGAGTTCAA GCGATTCTCC TCCTGAATAG CTAGGA'rrAC AGGTGCACCC CACCACACCC AGCTAATTTT TGTAT1TI'TA GGTrCGCCA TGTTGGCCAG GCTGGTTTTG AAGTCCTGAC CTAAATGATT CATCCACCTC AGTGCTGGGA TTACAGGCAT GAGCCACCAC GCCTGGCCCA GAGAGGGATG ATCTrTAGAA C'TrCAAGCC CTfCCTCCT CTCTGAGCTT TCTACTCTCT GATGTCAAAG CATGGTTCCT CCTCACCAGG CTCCCTCCCT CGCTCTCTCC GCAGTGCTCC TTCCAGGACC TGGACCTCTG GGCGGCATCC AGCTACGAAT CTCCGACCAC CACTACAGCA AGGGCTTCAG GCAGGCCGCG TGGCCATGGA CAAGCTGAGG AAGATGCTGG TTCCCTGCCC ACAGACCTrC CAGGAGAATG CTI7CTTTCCC TTCATCTTTG AAGAAGGTAG TTAGCCAAGA GCAGGCAGTA GATCTCCACT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT TCCCCCAGAG CCAAAGCCCT TTAAAGGTAG GGGGAGACAA AACAAAGAAG GCTGGAAACC AAAGCAATCA TCTCTTTAGT GGAAACTATT ATCTJTGATGG CTACTGACAT TTGCAACTCC CTCACTCTrT CTCAGGGGCC TTCACTTAC GAGGTTCGTA ACCTCCCTGT GGGCTAGTGT TATGACCATC ACCATTTTAC CTAAGTAGCT GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TCTAATAGTG TCAGGTCCAG CACCCCACTC CCAGC'FrCAT CCCTACTGGT GTTGTCATCA GACTrTGACC GTATATGCTC CAAGAAATCA AATTTTGCCA CCTCGCCTCA CGAGGCCTGC CTCCACAYTT CAGAACCTAT CT[CTTCGAC ACATOGGATA GATCACTGAA CTGCACGCTC CGGGACTCAC AGCAAAAAAG

CCITCTGATT

ACGAGGCTTA

CTTGGTGATG

TTATACCTAA

TGTGCACGAT

TCTGGTCCAT

AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGT'r CCTCCTGGCA GCT1'GCTAAT TCTCCATGTT 17AAACAAAG TAGAAAGTTA ATTTAAGGCA ACAAGTGAAA AAAAATAYI7A AAAAGGAATA TACAAACTTT GGTCCTAGAA ATGGCACATT GGCCAGTGCA 'ITTG'rrAACA GGAGTGTGAC CCTGAGAAAT TAGACGGCTC AAGCACTCCC CCACCCAAGT CTC'rrGGGCA TAGTGCAGTG TCAAIT[CTTC CACAATATGG GGTCATITTGA CTAACTGCCT GTGGGTTCTC TCTTCCTGTT GTTGAGGCTG AAACAAGAGT GCTGGAGCGA ATCCCCCTCC CCAGTCTTCC CCCCTrGCCC CAACATCCGT CCCACCCAAT GCCAGGTGGT GAAATTfAC CGCCCAGCAG GAACTTATAT CTCTCCGCTG TAACGGGCAA AAGTTTCAAG CCATCATTAG CTGTGGTGAT CTGCCTGGCA TCGTGCCACA GTAGCCAAAG CCTCTGCACA CAACTAAGGC TGCTGACTTT GAAGGACAGC CTCACTCAGG GGGAAGCTAT TFTGCTCTCAG AAAATCCTGT TrCTTTGGAA TCGGGTAGTA AGAGTGATCC CAGGGCCTCC AATITGACACT AGGAAGATCA AAATGAGTGT CTCTCTTI'GG AGCCACTTTC CCAGCTCAGC CTCTCCTCTC CCCATGGGCT ACTCTCTGTT CCTGAAACAG TTCTGGTGCC TGATTTrCTGG CAGAAGTACA T-TTCCTCC TTCCACAT-rG ATCAAGTTGT TCCGCTCCTG TGGATGGGCA CAYI7GCCAGC 239 CAGTGACACA ATGGCTTCCT TCCTTCCTTC CCTACTGCTA TGAGGCTCTG AGAAACCCTC GCTATTGTCT GTGAGAAGTC AAGTTATCCT GGCTACCAAT TACATGTATC CTACTCTCGG CACAAGACCC CCTTCTTTCT TCAGTGGTGT AATACCTGTG GCC17GGGCC TCAAGGAAAA ACTCTACAGC TGGAGGTAAG TGAATGCTAT CAGACAATTC ACCTTCTCCC CGCCCCCATC CATTAATGTA AATAAATTTA ACATAATf TCATTTTGCC GATGTTAT-rA TGTCCTACCA CTCAYJTTGAT AGACACCTTG GGAAATAGAT AATCACCACC ACTATCACCT CCAGCYITCT CATAAGGAAA AATACAATAA AAAGCCCCTG CCCCCAAAAA AAAAAAATTC TCACCTACAT AAGGGCTCTT TTAATAATCA CACAGAAAGT TGTGACCTGC TCGTCAGTTT CCYJTTCTGGC TGCCCCACAA AAATTCTTCT T-rCTCTT-rCGC TGGAAAAGCG ATT-fGTCTTC AACAAGATAG CAACTGGTAC ATCAGCACCT CTCAAGCAGA GATATAACTG ACTTCACCAT GCAATT-rGTG ATGTGGACTC AATCCCTAGG GCTGGCAGAA TCCTGTTG TCTACACCAA TGCCCAACTG GCCAGGACAG TCAGCTCTCT CC1TCAGGG TCTCCTACTC ACTTAAAGCC CGCCTGACAG TCGCTCCCAC ATTCTGATGA GCAACCGCTT TGGTCTAATT TATTCAAAGG GGGCAAGAAG GAATCAATTC AAT[TGGACT GGTGTGCTCT GCTCAGATTA TTTAAATGGG AATATrTATA CT-rCACTGAA GAAAAAAAAA AAAGGGTCTC AAACAGGCTG TGAGAGTTCT TGGGACTAAG TCCTTGGCCA CCGAAGACTA TCCTCCTCAC TGCACATCTG GAACAGGATC AGCTGAAGCA TATCTATCAA TGCACCAAAC ATCTGTTGAG ACAGTCACAA GTCCCTCCTC AGATAGGAGA CTUCAGGATI TAAAATGTAG ACCCTCTTC AGGCCTITGA GGGGAAACCC TAAATCAACA GTGTCY[AGG CCAAGGAACC TCACTGTGGG GGCTAGGGGT TGGGGTGACC CTGCATGCTG TCTCCATGTC CTTTGTACAA GGAGAAGAAA GAATCTGTAC CTGTCCTGGG TGTTGAAAGA

ATTCTCCGTTF

AAATGACCCT

TI'CCCACAGA

TGTCCCTAAC

GTAATGACAA

TGATAAGCCC

GGAATGAAGC CCTUCTCAGC CCTAGGAAAA GCTGGGAACA TAACTGCGTG CAACCTTCAA TAGTTACAAC CCCAACAGAT GACT1'AAAGG GTCCCATTAT CAGCAAAAGC TTCATTTCCA GAAACTAGGT ACTTCAAGAA TATGCTCCTC AGCATTTGGC TGGGGGCCCA GTTACAACTC CAACCCAAAG AACATCTTTC TGCAGAGTG TAGATCCCAA AAATCAATAA CAAGCTGGAA AAACATGCCC GTCTTCCTGG( TCTTCCTAAA GAGAGCTGTA AGGGAACAGA AAGGTTTI'TG CCTGCCTTAG GGTAGTGCTA CTCCTGCTAC CACTTATTCC GGTCTATTTG ACAAGTTTTG TCCTGCTGCA GAAAAYJTAAA TATATATTOT TAGGGCTGCT CACGTCCACT CCACTCCCAA AGTTGATGTC ATTCTAGGAC GCTCTAGCTT AATTTTCACC ACTAAGTTT AGAAAAGAAG AGGAGTCTGG CTCCTGATCA CCATAGGCAT CY7TGTCCCT ~AATTACCCA AAGAAGAAGA TTrGAGTCTG CCCAGTTCCC GAGGGACCAA AGGCGGCCAG CCCAGAGAGT CCTGTGCTGA AGTACGGCTA TAGCCTGGAC AGAGGATCTC CTGTCCATCA TGAGCCAGGC CTCTCTCACC TCTAAGAAAC CCTCTGTCAT GT[GTTTGT TTTGATTCAT CCTAGTTTYUT AATAGCTATG TTAAGACTGA AAATATATAA TTCAATGGTT CTGAAATAAA GATrOACACT GACAGTAAGC GCTGCAAGTA CCTAGAAATA

CCAATCCCCA

AAACCACGGC

CCCTATTTAT

TAGCAGTGTC

CTTTAAATCA

AATGAGCAAA

TCCTGATCAT

CCCACTCCTC

CCATCCCCT[

CTGCAGGGAG

GCCCTTTTGT

CACATTrTGGT TTA'rrTAlT

TGTAAAAGAG

AGTCCTTTAA

TATCATACTG

TGACTGTCTG

ATTGCTGAGT

TATTTrCGITG TTCAACAGAA GGATATTCAG TCAGGACTGG TAGTAACAGC TACCATGATT GAGTAAGATA GAAGAACGAA AGGGATAAAC AGAAGATTTC

GAGGAGTAGC

CACACATGGG

C.AAGCGCTAT GTACTAGGAG CTGGGAGTAC GGCAGCTAGT TATAAGCAGA ACAAGGTAAC CAGGAAGGAG GGAGGAGAAC GACATAAGAA CTGGGCCAAT TGGGTGTCGG TTACGCCTGT

AGAGATGAGA

ATGACAAGTA

TCAAGCCTAA

AATCCCAGCA

CTTTGGGTGG CAGGGGCAGA AAGATCGCT[ GAGCCCAGGA GTTCAAGACC AGCCTGGGCA ACATAGTGAG ACTCCCATCT CTACAAAAAA TAAATAAATA AATAAAACAA TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAGCTAC TTGGGAAGCT GACACTGGAG GATrGCTTFGA GCCCAGAAGT TCAAGACTGC AGTGAGCTTA TCCGTTGACC TGCAGGTCGA C ACAAACCTTT TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCAATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA ccT-rCTTTCC cTrCATCTr GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TrGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA T-rACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TI'CCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA A1TTGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTT1TTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCAGCCC T-rTGTTGAG CCAGGCCTCT CTCACCTCTC CTACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCCACAT TTTGGTTCTA AGAAACCCTC CTCTGTCA1T CGCTCCCACA TTCTGATGAG CAACCGCTTC CCTATTTATT TAT[-ATTTG TTTGTTTGTT TTGATTCATT GGTCTAATTT ATTCAAAGGG GGCAAGAAGT AGCAGTGTCT GTAAAAGAGC CTAGTTA ATAGCTATGG AATCAATTCA ATTTfGGACTG GTGTGCTCTC TTrTAAATCAA GTCCY[FTAAT TAAGACTGAA AATATATAAG CTCAGATTAT TTAAATGGGA ATATTrTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC TTCACT CTGGCAGGAG TAGCAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC AGACACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG AGCTrTCGCT TGCCGTCCAC CACTGCCCAC ACTGTCG1TJT GCTGCCATCG CAGACCTGCT GCTGACTTCC ATCCCTCTGG ATCCGGCAAG GGCCTGCGAT TT-rGACAATG TCAAGATTTA CCGTATATCC cTGTTrGT GGATACACCA GTGACGTCCA CT-rCTAGAAG ACAAAGTTAT ATTACTTAAA CAACCAAAGA TATGAAACTA TCCATGAAGA ACAATAUTAT CAATACACAG CAGTCTTG TAACCATGCC CAATGTGATT GTACCAGATA TTGAAAAGGA AATACGAAGG ATGGAAAATG GAGCATGCAG 240 CTCCT-17TCT GAGGATGATG ACAGTGCCTC TACATCTGAA GAATCAGAGA ATGAAAACCC TCATGCAAGG GGTTCCTTFTA GTTATAAGTC ACTCAGAAAG GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA TTGCCATTTr TAATGTGAAC AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGCGA

ATGGCCAAAG

CCATTGATCA

CATGGATCAA

ATGGTGGTAG

ATGATGACCT

CTTCCTGAGC

AATCAAAGTA

TGAAATTTGA

AAAAACTCAA

CCCAAAACCA

TCACATCAGT

GCCACCCTCT

TGTGCAGTGT

TGAGCATGTA

CATATAATGT

ATAACAATTT

GCAAA11TAAG ATTrCATGAT

TAAGTTFCTG

CAGflTTTITA

CAAAGCACGA

ATATACTATA

GTTITCTGGG

GCCAGGAAAC

AGCCAGTAAT

TCCACCTGCA

TCAAAACTTT

GTTACATTATr GGGAGTCAT7

TGGCGTTTGA

TACAGTGAAA

TAAGCTATGG

AACATCCAAG

CGGTTGAGTT

TCATCAAGCC

ATACGAATTC

GCTGCATTAC

CTAAAATTAC

AGTGCTGCTG

TGGGAAACTC

AAGACTACTG

GTAGGTCTGG

GCTAAATCCT

CTC11TTGTAA

GTACCAATCA

AAAAAGACTC

AGTCGAAACA

TTGCTGATGA

GAATAATACC

YI7CTCGAAGC

A'TTTATAAAT

CCAGGCATCC

TFTTGGTCCA

ATATAATAAA

TrACCTGGGC

CAACITTGAC

GGTTCTAAAA

TTCCAGACAT

TCTGTCTCTG

TCTGTGTCTC

TAGCAACCAA

GGAGGCCATC

AATGTGAAAT

TAATTCGAGC

CATGGGTGCT

TTGTATGTGA

TCACAGGTAG

TGCCCATCCA

ATCACTGACT

TGACAGTTCA

CTGAGCCTTG

TGTTAT[AA

TAGGAGGACC

GCATAAGAAA

TTCATT7CA

GGACCTCAGT

GTTTGAAGAC

AATCAGAAAT

TGAGTATCTC

CTGAAGAACT

CCTTCTATCA

TGAAACCTCT

CGGGAAGGTT CTGAAGAAGA GCCAATGACT CAGAGGAAGA ACAACTTTAT GAGGATCATG CAATGATCAG TACCTCACGG TATAAGTCAT CAAAGGATGA CTGCCCAAGA TGAAGACCAA TGAGACCAAC CTCCTCYITCT AACTTGTYI7A TTGCCACAAA GTTACAGTGA AAATGAAGAA GACAGTTCCT TGTAAGCTAT GGCCCACTCC ATGAAGGCTG AAAACATCCA AGCTTACCT-r CAAGGAGAGC GACGGTTGAG 1TTTAAGCCAA TCCATCACTG AATCATCAAG CCTAGGTCAG CACCTTTTAG AAATACGAAT TCATCCTGAA TGACGCCCTC CTGCTGCATT ACATAATCTG GATGAAGCAG TGCTAAAATT ACCGTGATTC TAAGAATCTC CCAGTGCTGC TGAAGGAGAT GCCTGAGATA TCTGGGAAAC TCACGGCACT AAGAACTATT GCAAGACTAC TGGGTGTGCT TGGCAGGGGG GCGTAGGTCT GGAGTCTCAC TTGTCTCACT AAGCTAAATC CTfACTGYI7 AGTCAT-rTGC CACTCTTTGT AAGAGTGGAA CCAACACTAA TAGTACCAAT CATrTTAATT ATTAT-rCTTC CCAAAAAGAC TCTACCCATA TTACAGATGG GCAGTTGAAA CAAGAAGCCA CAGACCTAGG AGTTGCTGAT GAACTCTTAA TCAAATAGCA GGGAATAATA CCTAAGCCTT CCTGCCGCAA

TTCAGATACT

TATGTACCAT

TAATTCTAAA

AGAACACCCT

AGAGCTACTG

ACTAAGAAAT

CTGTTITGCCT

TTfATCATTT

GGAAAACCAG

GTACATGAAG

TGAATGTTTA

ATATTTTGCA

ACTATGGCTA

ATGCACAATA

TCTGCTT=A

rCAAAATGGA rGCTAATCAG GGAGGTCATT AATGTTATTT TYJTAATITATT TTGGTAAAAT ACTTCTCGAA

TTTATGGGAA

ATAAGTAAGT

TCTGCATTCT

TGGTCCGATC

ATCAAGTCCT

CTTTTCTGGA

TATCAACAAT

CCCCYITCATC

TTGATTTCAT

AGTACTTGGG

T-17GACTCTT

ACAAGCTAAA

ATGTAATCAA

AGTGATTGAT

AYI7TATATAT

CTCTGAGTGT

TAATACAGGG

AGACCTGTAA

TYrGCCATTAA

ATTAGATGAA

TGTTTCTTCT

AGAGTGTTAT

GTATTTATAA

GACCAGGCAT

CATTTTGGTC

TCATATAATA

ACTTACCTGG

CTCAACTTTG

AGGTTCTAAA

CAGTCATAAC

GCCGAGCCTC

ATATATTTAA

CCTCCACAAT

CAAGTTGTGC

AATGTACATT

GCATTCTTGT

ACAACCATAG

AATI7GTGATC

TAAATAAAGC

AAGATGAAGG

GATAATTATA

AGCAGACAGT

TTATCCCATA

AAT-ACCT-G

TTCATTCAAT

ACCACTGTTA

AGACCATAAT

TTGCAAGTGA

rCATTGGCGT TTGAGTCAGC AAAGAAGTCA AG AGCTGCCAGC CAGAGAGGGA GTCATTTCAT GTCAGCAAAG AAGTCAAGAT GGCCAAAGTT CCAGACATGT ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCTCTGAA CCCACTCCAT GAAGGCTGCA TGGATCAATC CTTACCTUCA AGGAGAGCAT GGTGGTAGTA

TAAGCCAATC

TAGGTCATCA

ATCCTGAATG

ATAATCTGGA

CGTGA'FrCTA

AAGGAGATGC

ACGGCACTAA

GGTGTGCTTG

AGTCTCACTT

TTACTGTTAG

GAGTGGAACC

TTTTAATTAT

TACCCATATT

CATCACTGAT GATGACCTGG CCT'rTTAGCT

ACGCCCTCAA

TGAAGCAGTG

AGAATCTCAA

CTGAGATACC

GAACTATTrC

GCAGGGGGGC

GTCTCACTTG

TCATTTGCTG

AACACTAACA

TCCTGAGCAA

TCAAAGTATA

AAATTTGACA

AAACTCAATT

CAAAACCATC

ACATCAGTrG

CACCCTCTAT

TGCAGTGTTG

AGCATGTACT

TATAATGTTG

TGTGTCTCTG

GCAACCAACG

AGGCCATCGC

TGTGAAATAC

ATTCGAGCCA

TGGGTGCTTA

GiTATGTGACT TTGAAGACCT GAAGAACTGT TCAGAAATCC Y7CTATCATG AGTATCTCTG AAACCTCTAA GGAAGGTTCT GAAGAAGAGA CAATGACTCA GAGGAAGAAA AACT'I1TATGA GGATCATCAA ATGATCAGTA CCTCACGGCT TAAGTCATCA AAGGATGATG GCCCAAGATG AAGACCAACC ACAGGTAGTG AGACCAACCT CCTCTTCTTC

CCCATCCAAA

CACTGACTTTr

ACAGTTCATA

GAGCCTI'GTA

TTATTTAAAG

TATTCTTCAT AACAATFTA GGAGGACCAG ACAGATGGGC AAATTAAGGC ATAAGAAAAC AGAAGCCACA GACCTAGGAT TTCATGATTT CA'TTTCAACT ACTCTTAATC AAATAGCATA TAAGCCTTCC TGCCGCAACA CGAGCCTCAA GATGAAGGCA ATATTTAAGA TAATTATAAT TCCACAATAG CAGACAGTGT AGYJTGTGCTT ATCCCATAGC TGTACATTAA TTACCTTGAG AGYITCTGGG ACCTCAGT117 GTTIrTTTATG CTAATCAGGG AAGCACGAAA TGTTA1TTTT ATACTATATT TATGGGAACC 1TTCTGGGAT AAGTAAG'Tf CAGGAAACTC TGCA117CTAG CCAGTAATTG GTCCGATCTrr CTTGTTTATT GCCACAAAGC CAGATACTGG AAAACCAGGC TGTACCATGT ACATGAAGAA ATTCTAAATG AATG1TTACA AACACCCTAT ATTTITGCATA AGCTACTGAC TATGGCTACC TAAGAAATAT GCACAATAGC GTTTGCCTTrC TGCT1TrAAG TATCATTrTC AAAATGGAGG AGGTCATTTT GGTAAAATAC TAATTATTAT TTrATATATGT CCTUCATCCT CTGAGTGTGA GA1TTCATTA ATACAGGGCA TACTTGGGAG ACCTGTAATC TGACTCTF GCCATTAAAC AAGCTAAAAT TAGATGAACT TGTAATCAAT GTI7TC~rCTA GTGATTGATA GAGTGTTATC ATrC'rrGlTr CATTCAATTC CACCTGCAAT CAAGTCCTAC AACCATGAGA CCACTGrAT CAAAAC1TrrC TJTITCTGGAA ATTGTGATCA GACCATAATG YrACATTATT ATCAACAATA AGTCATAACT AAATAAAGCT TGCAACAAAA TT7CTCTG-3' (FRAG. NO:j(SEQ. ID NO:25 17) CCTAGTCTGG TGCTACACTT ACATTGCTTA CATCCAAGTG TGGTTATrC TGTGGCTCCT GTTATAACTA TTATAGCACC AGGTCTATGA CCAGGAGAAT TAGACTGGCA TTAAATCAGA ATAAGAGATT T-rGCACCTGC AATAGACCTT ATGACACCTA ACCAACCCCA -TATTTACAA TTrAAACAGGA ACAGAGGGAA TACTTTATCC AACTCACACA AGCTGTTC CTCCCAGATC CATGCTT'= TGCGTTTATT A1TTrAGA GATGGGGGCT TCACTATG'rr GCCCACACTG GACTAAAACT CTGGGCCTCA AGTGATTGTC CTGCCTCAGC 241

CTCCTGAATA

GGCTTAAACT

GCTGGCCACA

CATATGTAAA

GCTGGGACTA CAGGGGCATG CCATCACACC TAGTTCATTT CCTCTA'FfTA AAATATACAT CCAACTGGGA ACCCAAAACA TTCATTTGCT GGAATTATAA AAGCTGAGAA AYI'C'FTAAT AATCCATGCC TTCCTT-rCTC GGCCTTACGC ATACCTCCCG CAGAAGACCA GGCT-FCTCTC TCTCTCCTGA AGCTCCATCC CTTCTTTGTG CTCAAATACC CTGAGGTGAT TTATGCCTTA TTFGCCAGGAG CTGCCAAGTA CTACAGCTAC TATTAGAACT CACGATTTCT CCCTTCCTCC TGTCATCTTA TAAAGCAAAG AATAATATCA GCTATGCCAT AACTGAATTC TTCCCTGTAA GACAATTACA AAAGGCGAAG GCGTTTGAGT CAGCAAAGGT CTrTGGCTGT TTTCTCTCAC GGTTTGGTAT GTGACCTAGA GATTCGTTT[ ACTGAGGGAC CATGGGAGGG AATCTCTACT TACCTCTGTG TAAGGCAAAT ATGCCTGUTC TGGCAATACA AGTUrACGAT CTAATAAAGG

GGGCTTGCAC

TGGTCCTTGG

CCTCTATAGG

ACTGTTCTCT

ATCAAGCAAA

TTCTGCCAAT

ATTATTAFITA

TAGAAACTTG

GGGTGAATAA

CTUTCACTAT

ATITCCCCGTT

AAGACTGACT

ATTGTCCTCA

ATFGCCTTCT

ATTACAGTCA

GGCAGAACTA

ATCCAAAATT

ACCTTATTCT

TTAGGTTGGG

AGACAGGTAC

TTCAACAAAG

GAGCTGATGG

CTGAAGAACT

GAATCCAGCT

CCTGAAGTCA

TTGGCAGGGA

CAACTTAGAC

CCAATCTCCA

ACACCTTCTT

TAGAGGOCTA

kAATGTGTTG

TCTCTACCCT

CTTCCCTCYF

TCACCCTGGA

ATAAATTCCT

ATAAGTTTCC

ATGAACCAAA

TTTAGCCAGT

TTGACGACGC

CAGGCTTAAG

CATCTCTGGC

CTAAAGCTAC

GATTTCAGAA

GTTTCCTATG

ATTAGGAGAA

TGTGGTGTIT

CACATAAGGA

ATAGCAAACT

TTrTTCAGGAA

TGGCTGGTGT

GTTACAGGTA

ALGGCATAACA

GAGCAGGTTC

GACCGCCATT

ACAGCCTCTG

ATCTCAT7CA

CACTCAGATG

A

AAGAGTCTGG TGTI'CTACCA AATAGTAACC AGGCAACATC TTCCCAAACT TAGCCACTGG CTACAGAAGA CACACCYTGG OTITACTOTA ACAGGGCCAG ~CAATATTCA GAAGAGTAAG 3CCCTAACCA GGAGCTTGTC CAGAAAAGAT GGCTCAT"fTT 3CACAATCAA CAAAYITCAGC

CCTGAACTAG

ATTGAAGGCT

TTCTGGCTGA

GCATATCCTA

GGTGGAGAGT

AGGATCAAGA

ACCCCAAACT

CCCTCAAAAG

CAGAACACAA

CTCCAAATCT AGCCCC'FrGA CTTCGGATTT CGCGCTTCCC TTTTCTAAG ACTACATGTT TCAATAACTT CTGGAATATC TGCAAACAAC ATCGAGTTGA ATGAACATAG AAAAATACAA ACTTGTAGCC ACGTAGCCAC GCCTACTTAA CTGCCAGCCA GAGAGGGAGT CATTTCATTG TATTAAAGTA TTTTCTGTTG TTGTTTTTCT AGTCTCTCCT TTCT-rTTCTT GTCCCTCCCT AATGATTCTC TCAYFI1TGCT GATAAGGACT AGGGCATGGG TGAATACAAC TGAGGCTTCT AATrGAAAAT T-rCCAACTCT GTCTCTCTCT TTGTAACCTC TTCAAACTr CATTGATTGA ATACCAACAT AAATAAAACA TTCTAAAAGA AATTCAAAGG AGCTAGAAGA TGGAGAAAAT GCACAAAGAG GAGGGGCTCC CCTCACAGAT TCTCTGTTGC AGAAGTCAAG ATGGCCAAAG AGGAATAAGA TTTATCTCTT GTGATrTAAT

GCTGAATGTG

ATCTGGATTA

TTCCAGACAT

GAGGGTTTCA

TTGTAGAGAT

CATGTTAAAC

CCCTACATGA

GTTTTACTGG

GCATGTGAAC

AATTACGGAA

TCAAAATTTT

TGTGTAACAT

GCTTAACATf

AAGCACAGGT

ACCTATGTGT

CACAACTATC

GACTAAGTCA

GAGGCTGGCT

GTTTGAAGAC

AGGCTCACCA

GTGTACTAGT

TGAGATTACA

ATATCAGCAT

TCCATTCTCA GGAAAACTTG TCACATATGC AGGCAAATCT CATATTAAAC TAACATGATG TTTCCATTAT

GCCTGGATAT

ATAATCTATT

CTTCCCTGAA

AAAGCTCAAA

ATGTGTAGAA

ATGGTCATTA

TTTACTAAGT

TGGTTAAAAT

CT-rCAATrAA

GCCTGTCTTG

GTCCTTAAAT

AAGTACATTG

ATGAAGAAGA

GGACTGCTAT

TGTTTTACCC

AATAGTTGAT

CCTGGGGCAG

GTCTGTCTCC

ATAAATTATG

AAAAAGGAAG

AGCTCTTCAA

ATGACTACTA

TTCAAAGATG

GCCAGAGACC

CAGTITCCTCC

TCTJTACACAG

TCACTAGAGA

GTGCATTrGGC GC~rCATCAG

TAACGTGATG

GTGGCCAGCA TGGGGGCAGG AGAGAAGACC CAGAAAAACT TTAGAAAAAT TATTTTTGAG TTGAGATCAC ATGCCCTGAT GGAACAGGAA ATGGCTCCAC TAGAAGAAAG GTAAATGAAC CTGTAGTAAA TACTAACACA AAATCTGTYF TAGTGAATAC TGCTTCAAAA CCTTTCTTT T'TGTTAGCC AAGTCCAATT ATTCCAGATT AGTAAGATAT ACAGTAATGG CCATGTGTAT ACATGAAATA ACAACAATTA AITGATCATC TGTCTCTGAA TGGT-FTCTTC ATCCAAAGAG TCCAGAGACC TGTCTTTCAT TTCTCCCAGA ACAGAGCAGA

CCGGCAGAGG

AAGCATTCAG

GTCTGCTGAG

ATAAGAATGG

AGCAAGCTGG

ACAAAGATAA

AACTAGGCTG

ATGAAAGTAA

CTCTAAAGGA

TTTACAGATA

GAATfACTCT

GTGTGTGACC

CATfCTCATC

TCAGGTAAGC

AACAGCAATG

TATAAGTGAG

ACTATCCCAA

ATCTTAUrTT GACAGTGAAA AAATGACTGT AATTCTCATG ACTTGAATCT TAAATACTTT ACCAGCTGCC TCTCTAAACT ATCCCTGAGA ACTGGAGTCT CGCAGGCCGC TTCACCAGGT CAGAGGTTAG AGAAAGTCTC TACAGCCACT CATCAATCTG TGTCTTCAGT ACTGGCTTTA AGATTTITTAA CCTCCTGAGA AGTTACAACA TCTCATTTT CTGGAAGGAG GAAGGAAGGT AGACCAGAAT GGAGATCCTC GACCATGAAC AGCCTCTCAG CACTCCATGA AGGCTGCATG TACCTTCAAG GAGAGCATGG AGCCAATCCA TCACTGATGA CAATAATATC TTTCTTTTAC GTCAGAATAA CAAGAAGACA CTCCAGGAGG GAGAAATGAG ATTGTAAAGG TCGTGTGACT CTCTCATACT AACTATGCCT AATGGAGATA ATCAGAATCC GAGCTAGCTG GGCCCTCCTG TAATGTCTGG TACAAAGTAA CAAACATGAA GCTGAGAGAG TGTITATTGTG T7TGGAGACC

GATGTTAGTT

TGTTGTGGTT

AGGAAGCAAG

ACAAATAGAC

ATTTCTAAAA

CCACTCACTA

AAGTC11TCCT

AAAGCTGTCC

GGGAACTAAT

GAGCATGCAA

GAGACAAAAG

CTCACTACCT

CTTCTGTT1

GATCAATCTG

TGGTAGTAGC

CCAAAGGAGT

TGGAAAGCTA

ATAAATGAAA

ATGCCATCCT GAGAAAGCCC GTCTTCTCTG ACACCAGGAT CCAGCTGAAA GTGAGAAGTC ACTATAAGTA CTGCCTAGTA TATTTTGAGC ATTGTTAAGC CAATCATTGT TAACCTATTT AAAAAAATCA TCT-=rATC AATGAAACAC CAGTTACCTA TGAAAGAACT TTCATrCCCT CTATCATGTA AGCTATGGCC ACCTCTAAAA CATCCAAGCT AGAAGAGACG GTFrGAGTTTrA GGAGAGAGGG AGGGAAGCCI CTGTTGAATA CAGCACCTAC CC1TCCTCAC AGAAATCCTT TGTCTCTGAG TATCTCTGAA AACCAACGGG AAGGTT7CTGA TGACCTGGAG GCCATCGCCA ATGACTCAGA GGAAGGTAAG GGGTCAAOCA kGTITTTAAGC AAGTAGGGAC AGTAGAATTT AGGGGAAAAT TAAACGTGGA ACCAAGCATT AGTCTGGTAA CTATACAGAG GAAAATTAAT 1T=ATCCTT CAGTGGCCTG AATCGAGAAT ACTTGCTCAC AGCCATTATT TCTTAGCCAT IFAGCCTTT CAGGAGAAAG CAGTAATAAG ACCAC'FrACG AGCTATGTTC CCTJTGGTCAT GTI'ACATAAT CTTTCGTGA 17CAGfT1CC TCTACTGTAA CCCACTCATT GGATTGTTGT AAAGATTAAG AGTCTCAGGC TTTACAGACT ACTGTTATAA AGATrAAATG AGTCAACATC CCCTAACTrC TGGACTAGAA GCACCCAATA AATGTTAGCT ATTACTATCA TTATTATTAT TATT-FTATT"T TTTTTTTTG AGATGGAGTC TGGCTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AAGCTCTGCC TCCTGGGTTC ATGCCAT-rCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCACC 242

CGCCACTGTT

GTGATCCACC

TATTATTATT

TGTCTAAACC

AACTGCCCAA

ATCATGGT

TTAAGATAAT

TAAAAATCAC

GCTATACACA

AGcTfTTcT

ACAATGAACA

GTAGAATTTC

ATATAATTAT

TGGTAGTCTT

AAAACAATGA

CTAGAAAACC

TAATACCCCC

CATTAATCTG

GCAATGTGAA

TATAATTCGA

AAATGGCACC

CTTGCAAAAA

CCCCATAAAA

TATCTTTGAG

YUTACCCTCAA

CAATGAAGAA

ATCTTTATTA

TGAAGTTTAG

AGTATACATA

GCACTTCAGC

TAYJTTCTGCA

ATCAGGTTGC

TTGTTT1TC

AATAATTTGA

AACATATGAG

ACAGGGTCTT

CGTAGAAAAT

ACAAAGATGT

ACACACACAC

AAATACAATG

TCATCAAAGG

AAGATGAAGA

CATATGTTTG

CACAGCCCCC

TATAACAGAG

ATCCCAGAGC

TTAGGACAAT

CCAATGGGCA

CCCGGCTAAT T11TTTGTATT CACCTTGGCC TCCCAAAGTG ACTACTACTA CTACCTATAT TCACAAGAAT CCTACCTTCT TGGCATACAT CTGTAAGTGG CTCCTCCATC CCTTTFACTGT ACCTAAGCAA TAACGCATGT TCATATCGTC AGTGAGAGTT TACCTACATG TGAACAAATA ACTTAGCAAT GTATTGAGGA TCTGTATAAA TAAATATTCA CCAGAGCCAT GAGGATTTGT TTfAATGCA TTCATTTTTT CCT'TGTCAGT TAGAAACACC AACTATTGCC TGAGGAATTG AGTTCTGCTG ACTGGGTGAT TCCAGAACTA TTCCCTGT CACTI7GTGAT CATGGYFTTA ATACAACT1TT ATGAGGATCA GCCAATGATC AGTACCTCAC AGACATTTCT GTCATCCTCC ACATACCTCT TCAGAGTTCT ATCCCAAGCC AGGGCAGAAG AGTAAAGGGT TGTGCACAAA

TTTAGTAGAG

CCGGGATTAC

GAATACTACC

CATTTTACAT

GAGAGCCTCA

ACAAGCCTCC

TCACCTAGAA

TACTACTGCC

TGTCTAACAT

CATTTFTAGAG

'ITTCTCTCAC

GACGCTATTG

ACGGAGTC ACCGTGGTCT CCATCTCCTC AGGCGTGAGC CACCGCGCCC GGCCTATTAT AGCAATACTA ATTTATTAAT GACTGGATTA AAAAGGAAAC TAAGCTCA~r GAGATAGGTA AATCTAATTC AGTTCTACCT GAGTAAAAAA ACATGAACTA TAAACCCAAT AT-FCCTGT GGTTTTAAAA TGTAACAAAA TATAAGAAAA AGCACTATGG TATGTTTCCT TAAAATCT-T CAAGACCACA CTATTTACAA C'FrTATATCC TGCCCGTT TCACCATTAT AAGCAATGCA CCTrrATTTC CTfTAGAATAT ATTCCTAGAA ATATGTGCCA CTTTGCACTC TCTGTGACAT I'CTCAGAGTG CATTCGTTTG AAAACATAGA CGGGAAATAC

CAAACAATGA

AAGT1TAAAA TI7CACTTCTC

TTGTACTAGA

GAAATCATCA

TCAAATACGA

GGCTGCTGCA

CCTCCT7[I'CA

GGGTTGCACA

GTTCAACTAA

AAAATGAAAA AGTTGCACAA ATAGTCTCTA AGAAGCACAT AAGCAACAAC AAGGATAATC TTTGCTTCCT CATCTGGATT GGAATATTCC CTGTGTATAT CATCTGTGTT TGTACATAGA AGjCCTAGGTC ATCACCTTTT AGCTTCCTGA ATTCATCCTG AATGACGCCC TCAATCAAAG TTrACATAATC TGGATGAAGC AGGTACATTA TTTACTTATT TATTTATTTC AATCT[TCTG ATTCTTCCAG AATAGCTTGA AGCACAGCAC ATCTGGAAGT TCCACAAGAG AGAAGTTTCC GCTAGCTGAT GTACTACCTC TTTfGGTTCTT TCAGACATTC TTTAAAACT GAGGAAACTG TCAGACATAT TAAATGATTT CAATCACTCT CCTfAAAAA GTCTGTTGAT CAAACTCACA TCTCTGATAA CATATTTGTG AGGCAAAACC TCCAATAAGC TGTCCAAAAA CTTTTATCAC ACACATCCAA TTTI'CATGGC TTTTCAAAGG TCCAGAGAGG CAAT-rTTGCA ATAAACAAGC TAACATGCFJ7 TCAACTCTAC ATTTACAAAT TATFTGTGT A'ITTTCCCAA TATTGACATC GTGTATGTAT TTGCCATTTT TACGTrGGTC CCTTGGGTTT ACTCTAAATA GCTTGATTGC TCCTATCTTG TAATTTCTrT GAGCACATCC CAAAGAGGAA

ACTCAGATIT

AGTAACACCA

TACAAATATG

GGACATGT-T

AAGACTTTTr

TCTATITTC

TAATATCACT

AAATATCTTT

TGCCTAGATC

CAGCTCUrAT

TGTATCAGCT

ATCCCACTAA

TCTAAGAACA

ATAGAATTCC

ACACACACAC

AATI1TACTTT

ATGATGCTAA

TAAACATrAT TCTGTAAGTA AAAACTGAAC TACTTTCAG TCCTAAACCC CTCCATGTTA GGTCATTATG AACTTATGAT TGAAATTATA AGAGATTCAA CACTTATTCA GCCCCGAAGG TrAACCAAGT A'ITTACCTGC CTAGTGAGTG TGGAAGACAT ATTCCTGACT TCCAGGTATT TACACCATAG GTGGGGACCT ACACACACAC ACCATGCACA CACAATCTAC ATCAACACTT CTTTTTGGTT CTTCTCTTCA CCAGTGAAAT TTGACATGGG AATTACCGTG ATTCTAAGAA TCTCAAAAAC TCAATTGTAT

ACCCAGAAGC

AACCAGGAAG

GCTTAAAGGA

TAGTTTCAAC

CTGATrGGAT

TACTTAATAT

AGACAATTCA

GTATATATTA

AATGGGCACA

TATCACTAGC

CTAACAAATT

ATrCATTCAA

TGTGAAGGAC

AACTACACAC

GATTT-rATAC

TGCTTATAAG

GTGACTGCCC

ATFrTACATCT

TCCTTCCTAC

TATGAGAAAA

CCAACCAGTG CTGCTGAAGG TCAGTI7GTCC TTTGTCTCCA ACTTACCTTC TAAATAAGCC CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTCTT ACCTACCCAC CCCACTCCCA 'ITGATTCCAG AGGCGTGCCT AGGCAGGATC AGTAAGAGGA AAATTACCTT CTTTCTflT ATCCAYI1AT

GTGGCCTGCC

CAAAGCAACA

CTCTGCATTG ATGTCAGCAT CACACACACA ACAGCCTTAG AAGACCTTCT AUrCCCAAGT CAGAGTAGGG CAGTAGCTTC CAGGCATAGT GCCAACAGCA TGGAGGATAT GGAAAACAGA GAATAGGGTG CTAAGATAGA GTGAGATGAG AGCTGCCGAC GGGGCGGGTC GTGGTTGTGG TYrGGGTAGGA CATTCAGAGG GGCGGGTCGT GGTTGTGGGT ATGGTAAAGG ACAGCTCCAA ATATGCAGAG ACTAGTGCTT GGGTTTCACA CAGTGCAATG CAATAGAGAA GCAGAAAGTC GGAAAGAAAC AGACAGAATr TITACTGAGAA GGGAAAAAGT AGGAAGCCTC AAAAGTATAT TCCATTGATC TTTACTGACA TCCAAGAAAC TCAAATAAGC AGCTGGGAGC CAAGTCCCAA TATCCTTCGT CCCAGTCCTG ATGTTTTCTC CACTGATAAG AGAATTTATG TGCCTGCCTG ATTCATGAAC TCATTCAACA GTGTGGACAG TGGTGCATCA CAACCCAAAC AACCAACAAA GAAAAGTGGG AGAGTGCTAT AGAGGGGGCG GGTCATGGTT GT1TTTGGGT AGGACATTCA AGGGGGCGGG TCGTGGTTGT TTTTGGGACA TTCAGAGGAG CCMTCCCTG CCTGACCTTrA 1TCACCTCCC TCTATTATCT GACCTACACA ATACTAGACA CAACTGAGAT CAGAGAGGAT TAATCACCTG AATGGGGCCT GCTGCTTCCA GTTCCCCTCT TCTCCACTAC CACTTTCCCC CTCAAACACA TAGGTGACTC AAYI7TGTAAG TATATAATCC TGCTTTTCTA CCTGGATCAA GTGATGTCTA AGCATTATTC ACTGAGAGCC TTGTATTrTTT AAGCCTCTAG TCTCATAGAA CTTAGTCTTC AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT 'FTAGACAAAG TGGTAAAAAC AAAGCCCCTT GTGGGTTFT- GGGTAGGACA TTCAGAGGAG GAGGAGGGGG CGGGTCGTGG TTGTGGGTTT GGGTTT1GG GTAGGACATT CAGAGOAGGG TCTGAATGCA CCCAGGCCTA CAACTTCAAG GGATCAGAAG AAGCATTCTT GGAACTGGGG CAT-TIGAGA AGGAGGAAAA GCAGAGCTTG CAT1TGGATT TCATTTGAGG TACAATGAAA ACCCATTAAT GCCTGACCTC ACTTATATTT CCTAAAATAG AAAACAGATC AGAAGGAAGG CAATGAGGAG GTTTCACAGC AGTCATGGGG GTGGGGTAAG GAAAAGAAGT GGGTTATATT TTGGAGATAG AACCAACAGA AGGAAGAGGA GAAACAACAT AGGAGAGGAA TAGGTTTGGG AAATAAATCC TGCTGACATT GGAAACCCCA T-rACTFrGCTT TAGATTTAAA AGAATAGGAA AGAAGCATCT CAACTTrGGAA 'TIrGAAATCT ATTTTCCAT AAAAGTATTG TTAAATTCTA CTCATACTCA CAAGAAAAGT ACATTCTAAA 243

GAGTATATTG

GTGTG1TTAA

AAAGGTATGA

GATGCAAAAT

CAGTAAGATA

CAACTCTTAT

AATGAAGAGC

AAGGGATTGA

AGATGCCTGA

CACTAAGAAC

TGC11TGGCAG

TCACITGTCT

TGTTAGTCAT

GGAACCAACA

AATTA11TATT

CATATTACAG

GCCACAGACC

TTrAATCAAAT

CCTTCCTGCC

CCTCAAGATG

TT1AAGATAAT

CAATAGCAGA

GTGCTTATCC

CATTAATTAC

AAAGAGTTTA CTGATATACT TAGGAATTTT CCYJTCAATTG TTGACTTAAA TACTGAGATA TT-rGTTCACT TGGAGATCAA AATGTTTAGG GTCTFAGGCC TATGUTGAAG GCAGGACAGA CTAGTGTCAC TGACAATCTT CATAACTAAT TAATAGACTG GGCCACACAT CTACTAGGCA CTATAGCATC ATGTTACAGC CATAGTCCTA GCTTCAGTCC TFTrCTAAC ATCTTGT-TCT GATACCCAAA ACCATCACAG GTAGTGAGAC TATTTCACAT CAGTTGCCCA TCCAAACTTG GGGGGCCACC CTCTATCACT GACTTTCAGA CACTTGTGCA GTGTTGACAG TTCATATGTA TTGCTGAGCA TGTACTGAGC CTTGTAATTC CTAACATATA ATGTTGTTAT TTAAAGAACA 11TCATAACA ATTAGGAG GACCAGAGCT ATGGGCAAAT TAAGGCATAA GAAAACTAAG TAGGAYFTCA TGATTTCAT7 TCAACTGT-17 AGCATAAGTT TCTGGGACCT CAGTTATC GJCAACAGTTT TTTATGCTAA TCAGGGAGGT AAGGCAAAGC ACGAAATGTr AT1T=TAAT TATAATATAC TATATTTATG GGAACCCCTT CAGTGTTTTC TGGGATAAGT AAGT11TGATT

GTGTGTATGT

AATGTCATCT

GGGCTTAGAA

AACAATGTTT

TTFAGATCTCT

TGTAATAAAT

AAGTGjGTGTT

CTAACAGAAT

CAACCTCCTC

TTTATTGCCA

TACTGGAAAA

CCATGTACAT

TAAATGAATG

CCCTATA1TT

ACTGACTATG

AAATATGCAC

GCCITCTGCT

ATTTTCAAAA

CAT'=GGTA

TATTATTTAT

CATCCTCTGA

TCA1TAATAC

GTGTGTGTGT

AAATGCTAAA

TCACTGTAGT

CCCTCCTACC

CTCCAATCAA

GCTTGCTGAA

TCTCATGAAG

TCTCTTCTTr

TTCTTCTGGG

CAAAGCAAGA

CCAGGCGTAG

GAAGAAGCTA

TTTACACTCT

TGCATAGTAC

GCTACCAAAA

AATAGCAGTT

TTTAAGTTGC

TGGAGGGAAT

AAATACTTCT

ATATGTATTT

GTGTGACCAG

AGGGCATT[T

GTAATCATAT

TTAAACTTAC

TGAACTCAAC

CTTCTAGGTT

GTTATCAGTC

TTATI=ACT

TATAAAATCA

AAGAATGATA

TATACAAACT

ATGTGTGTGT

TTGATTTCCC

GCTCAGATTT

TGCCTGGATA

CTAAGGAAAT

TGAACAAATG

GCCAAATGCT

TCTTCATAGG

AAACTCACGG

CTACTGGGTG

GTCTGGAGTC

AATCCTTTAC

TTGTAAGAGT

CAATCATTTT

AGACTCTACC

GAAACAAGAA

TGATGAACTC

AATACCTAAG

CGAAGCCGAG

ATAAATATAT

GCATCCTCCA

GGTCCAAGTT

AATAAATGTA

CTGGGCATTC

TTTGACAACC

CTAAAAATTG

ATAACTAAAT

GCATGGTAAT

AACCAAGATT

ATATTTCCGG

CACACATACA

CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT CTTGAGCCAG TAATTGGTCC GATC17TGAC TCTT[GCCA TTGTTTCATT CAATTCCACC TGCAATCAAG TCCTACAAGC TAAAATTAGA ATGAGACCAC TGTTATCAAA AC1TJTCTITTT CTGGAATGTA ATCAATGTTTF TGATCAGACC ATAATGTTAC ATTATTATCA ACAATAGTGA TTGATAGAGT AAAGCTI'GCA ACAAAATTCT CTGACACATA GTTATTCATT GCCTTAATCA TAGGGACAAA TGGTAAATGT YFACATAAAT AATTGTATrT AGTGTTAC'Fr TTATATTITTT TrcTCCTCT-f TGT-rAGCTGC CAGTATGCAT AAATGGCATT GTTCACTTAA AGCTCATATT ACACATACAC AAAACATGTG TTCCCATCYT GAGCTACATT AAAAACAACT AATAGGCCAG GCACGGTGGC TCAGACCTGT AATCCCAGCA C1TfGGGAGG 3' (FRAG. NO:_ (SEQ. ID NO:2510) TCGAGGCACA AGGCACAACA GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCATTGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TGAGCTCGCC AGTGAAATGA TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA

GCCCTCTGGA

GTCAGTTGTT

GACCTGAGCA

CTTATGTGCA

GATGTCTGGT

TCCATGTCCT

ATCTGTACCT

TTACCCAAAG

GAGTCTGCCC

TGGCGGCATC

GTGGCCATGG

CCTTrCTTTCC

CGATGCACCT

CCATATGAAC

TTGTACAAGG

GTCCTGCGTG

AGCTGATGGC

CAGCTACGAA

ACAAGCTGAG

CCTAAACAGA TGAAGTGCTC TCTCCGACCA CCACTACAGC GAAGATGCTG GTTCCCTGCC CTTCATCTTr GAAGAAGAAC GTACGATCAC TGAACTGCAC TGAAAGCTCT CCACCTCCAG AGAAGAAAGT AATGACAAAA TTGAAAGATG ATAAGCCCAC CTATCTTCTr

GCTCCGGGAC

GGACAGGATA

TACCTGTGGC

TCTACAGCTG

AAGATAGAAA

AAGCAGAAAA

CTTCCAGGAC CTGGACCTCT AAGGGCUTCA GGCAGGCCGC CACAGACCTT CCAGGAGAAT CGACACATGG GATAACGAGG TCACAGCAAA AAAGCTTGGT TGGAGCAACA AGTGGTGTTC CTTGGGCCTC AAGGAAAAGA GAGAGTGTAG ATCCCAAAAA TCAATAACAA GCTGGAATTT CATGCCCGTC TTCCTGGGAG TCCTAAAGAG AGCTGTACCC GAACAGAAAG GT-TTTGAGT GCCTTAGGGT AGTGCTAAGA ATCCCCAGCC CT1TGTTGA CCACGGCCAC A1TTTGGTTCT AAGAAGATGG AAAAGCGATT TGTCTTCAAC AGT-rCCCCAA CTGGTACATC AGCACCTCTC GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTJ7GTGTCT AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA GCCAGGCCTC TCTCACCTCT CCTACTCACT TAAAGCCCGC CTGACAGAAA AAGAAACCCT CTGTCATTCG CTCCCACATT CTGATGAGCA ACCGCTTCCC TATTTA'FrTA TITTAYI17GTT TGT-FTGTTrT AT-FCATTGGT CTAATTTAYF CAAAGGGGGC AAGAAGTAGC AGTGTCTGTA AAAGAGCCTA G1T=TAATA GCTATGGAAT CAATTCAATT TGGACTGGTG TGCTCTCTI AAATCAAGTC CTTTFAATTAA GACTGAAAAT ATATAAGCTC AGATTATTTA AATGGGAATA TTTATAAATG AGCAAATATC ATACTGTTCA ATGGTTCTGA AATAAACTTC TCTGAAG-3' (FRAG. NO:J(SEQ. ID NO:251 1) AGAGAGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGAAGG AAGAAAGACA GGCTCTGAGG AAGGTGGCAG T-FCCTACAAC GGGAGAACCA GTGGTTAATT TGCAAAGTGG ATCCTGTGGA GGCANNCAGA GGAGTCCCCT AGGCCACCCA GACAGGOCTT UTAGCTATCT GCAGGCCAGA CACCAAATTTF CAGGAGGGCT CAGTGTTAGG AATGGATTAT GGCT-fATCAA ATI'CACAGGA AACTAACATG TTGAACAGCT TTTAGATTTC CTGTGGAAAA TATAACTrAC TAAAGATGGA GTTCTTGTGA CTGACTCCTG ATATCAAGAT ACTGGGAGCC AAATTAAAAA TCAGAAGGCT GCTTGGAGAG CAAGTCCATG AAATGCTCTT TrTCCCACAG TAGAACCTAT TTCCCTCGTG TCTCAAATAC TTGCACAGAG GCTCACTCCC YI7GGATAATG CAGAGCGAGC ACGATACCTG GCACATACTA AT-7TGAATAA AATGCTGTCA AATTFCCCATT CACCCAT1CA AGCAGCAAAC TCTATCTCAC CTGAATGTAC ATGCCAGGCA CTGTGCTAGA C1TGGCTCAA AAAGATTTCA GTTTCCTGGA GGAACCAGGA GGGCAAGG'rr TCAACTCAGT GCTATAAGAA GTGTTACAGG CTGGACACGG TGGCTCACGC CTGTAATCCC AACATTrGGG AGGCCGAGGC GGGCAGATCA CAAGGTCAGG AGATCGAGAC CATCCTGGCT AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAAAT TAGCCGGGCG TTFGGCGGCAG GTGCCTGTAG 244 TCCCAGCTGC TGGGGAGGCT GAGGCAGGAG AATGGTGTGA GATCGTGCCA CTGCACTCCA GCCTGGGCGA CAGAGTGAGA TGATGCAGAC CTGTCAAAGA GGCAAAGGAG GGTGTTCCTA TCATTCATTC TACAAATGGA GGGCTCCCCT GGGCAGATCG TAAAGAGAAA CTGATAACTC T-G~GTATTAC CAAGAGATAG TATTCCCACT TrAGAGTr CACCAAAAAA TCATTTrAGG ACCCGGGAGG CGGAACTTGC AGGGGGCCGA CTCTGTCTCA AAAAAAAAAA AAAAGTGTTA

CCATGAGATT

AACTCCGTCA

CTCAGAGGCT

CTCAATACAG

CTAAACTTAA

GTCCCACATA

TGCACAACGA

CTACTCCTrG

CCAATACTCT

TCCTACTTCT

CACAAGGCAC

TCCTfACAAC

TCTCTCTCTT

CCAGGTGTAA

ACCCTAAAGG

TfAGCAAATG GGCTAGGGTA ACAGCACCTG GTCTTGCAGC GGAGCCTGAA CCCTGCATAC CGTATGUTCT CCTGCAATFG ACAGAGAGCT CCCGAGGCAG ACAGGGAGGG CTATTGGCCC TTCATTGTAC GTACAAAGAA GTGAATGAAG AAAAGTATG' TACTAAATTT AAACATITCTT CTAACGTGGG TTGTCAGGAA AACAATGCAT ATTTGCATGG CCCTTCCATG AACCAGAGAA TFATCTCAGT TTJ7CCCCTT[ CCTTTAACTT GATTGTGAAA GCTT=GAAA GCTATAAAAA CAGCGAGGGA AACAGGCTGC TCTGGGAT-TC TCTTCAGCCA TAGGTGCTAA GGGAGTCTCT CTGTCTCTCT TCTTTCTCTG TCTCTCCTCT CCTfCCTCTC TATAATGCTT ATGACTCGGG AAATATTCTG CACTCCAGGC ACTGTTCATA CTGGAGCAGG CACTTTGCTG AGTCTCAGAT GGATATTCTT CAGAGCTCAT CTGGCAflGA GTTGTGTGAG CUTATCTCCA CTGCCCCAGC CAAGAAAGGT AGAACAGCAC CCAAGGTAGA CCATYITATCC ATCTGTAAGT T GCATGTATAA ATCTGTGTGT AAAATCCAGT ATTTTAATGT TGATACAT[ GCAAAATGTG TTATrAGTCC CCTCCCCTAA TCAGGTATTC AACAGAGAAA GAAACTGGCA GATACCAAAC ATCTI'CATTG CTCAAGTATG GCCTCTTTGT GTGTATGCAT TGCCTCCTCT CTCAGCT1TTT GGAATGGATA CTGCT-rATCT TAGCCAATAC ATTGCTAGTT CACACATrCA Y7CATTTACT CACACATGAA CGTAGCCGTC ATGGCAGAAG TACCTGAGCT

ACCTGGACTC

GTGTCTCGGT

ACAGAAACAA

TCTGGTTCAT

GGGTTGCCCC

CAATITICTC

GACCCACACC

GGGAAGATTC

C'FrCCACTTT

GGACATCAAC

TCATAGTTTG

GAAGCTrCCA

TTTCTCAGCC

CTCTFCGAGG

ACT11TAATCT

ATTCTCTCTC

TGCAAAAATG

AACAGCTGAC

GGGGT-1TGGT

CAGAGATCAT

ATGGGGAAGT

CGCCAGTGAA

TTAGTGTCAJ0 CTTTrCTCTA AGCCTCTGCT CCAGCTCTCC GACGCAAAGG ACTTCTCT-T CACTGGATGC TGAGAGAAAT CACAGGTGTC TGAAGCAGCC T-rCTTTGCAT GACTGCCATG CACTCATTTr CTCCTFTTA ATGATGGCTT ATTACAGGTC AGAGTGTTAT CTGTGCTTGG AAGTAAATCT GATTTAAAGA GATGTOTTOGT TGCAAGGGCT ATCCCMTGC AAAGTGTGGC GTTAGGCCTC AAGATCCAAC TGT-rCTGCGC ATATCACTGT TrCT7ATGAA CAGTCAAGTC ATGTCCCTGT TTI1TATTACA AAGGTAAGAC TATGGGTI'TA GTTCTGGGCC ACTTTGATGC CTGCACCACT TGCTGACCTG GGCCACACTT GGTGGTGACA TCTTCAACAT AAATrTGATT TGAAACCAAG AGATGATCTTr AGTGGAGACG CTGAGACCAG TAACATGAGC AGGTCTCCTC TTTCAAGAGT AGACCAGATT TTTCCCCTAA ATTGCCTCTT TCAGTGGCAA CTAC1TFCCC ATTACAAGTC CCTCCAGCCT TGGGACCTGG TCCTGCAGAG GCAAATGGGG AGAAAAGATT CCAAGCCCAC TTGGAGGGAG AGGGAGAGCT CAGATTTTAG CTGACTCTGC AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CTAGAATCTG GAAACTTGCC AGGTGTITCA GGCAGCTITG AGAGGCAGGC TTGTACACAG GGAAGGAAAA ATAAACCTGT TTAGAAGACA GTGGCAATGA GGATGACT-rG TTCTTTGAAG CTGATGGCCC ACTCCCAACC CAAGGAAGGG CTCTAACACA GGGAAAGCTC CATGGTATY[ TGTTFFTAGAA AGACTTTAAC CTCTTCCAGT GCCACTTGGT CATCATATCA CCACAGTCAC TCACTAACGT GGGGAGGAGT AGTGATAATG TTCCCATTTC ATAGTAGGAA ATCCTI-TAA GAGATGGATT CAGCCTATGC CAATCACTTG

ACAGGGTGCC

AGGCTATCCA

AATACAAGGA

TGGGCTAGAG

CCTTCTGGAC

TGTTITGCAGT

TAATTGAGAC

TAAACAGATG

AAAGAAGGGA

GAGACACAGO

TGGTGGTGGT

GACAACCAAG

AGTTAAACTC

GAGAACTAAC ATATGTCTAC CCCITrTGAG TAGAATAGTT TTTTGCTACC

TGGGGTGAAG

CCATTCACTT

TGAGCTGGAT

AGGGCATTUG

TCCCTTCTGT

TGCAGGTTGG

ATAATCCAGT

TGCAGCTGTG

GGCTCTGCTC

TCTTCAAGC

CTTATAACAA CAAGACATAG ATGATATAAA CAAAAAGATG GCTGTTTGAC CTrGACAAGT CATTACCC GCITFrGGACC GATCTCTGAG ATTCCAGCAT CCTGCAACCT CCAGTTCTGA GGCAGCAAAT GGTCATTTTT CAGACTCATC CTTACAAAGA TTTATATGAT GCTCAGTAGC CTTrCCTAGGT GCCCAGCCAT AGGCAGCCAC TfTTTCTCTGG CTYJ7ATTTTA TTCCAGTTrG CC-TCAATCTT GTrAAAAACA TATTTCTTTA GAAGTTTTAA GGAGGAGCCC ATITGGCTTGT CTGCCTGGCC TTTGCCCCCC CAGGCAGGAA ATI1CTCTCCT GCTCAACTrT CTI=GTGCA CTTTGAACCA TTATCAGCCT TAAGGCAACC TCAGTGAAGC

AATTGAGACT

TCATCTGAAA

AATATTTTCA

GCCATGTTAT

CAGCCTAGCT

TGATAGCCTC

GACTGGCATA

ATTGCCTCTT

CTTrACAGGTC

CTTAATACGG

TGAAAGAAAA

AATAAAGGGC

GTTGTAGCTA

ATTCCTGCTG

AGGTCAGTTG

CCCTAGCCTC

ACTTCYTGGC

CCAGCAGCT7r

TCTTTAACTG

AGCTTCTCTG

AATAAGAGGA AAGTGGTAAC ATTTCACAAA AAGTACTCTC ACAGGA1TTTG CAGAATGCCT ATGAGACAGT GUTATGAAAA AGGAAAAAAA AGAACAGTGT AGAAAAATTG AATACTTGCT GAGTGAGCAT AGGTGAATGG AAAATGTTAT GGTCATCTGC ATGAAAAAGC AAATCATAGT GTGACAGCAT TAGGGATACA AAAAGATATA GAGAAGGTAT ACATGTATGG TGTAGGTGGG GCATGTACAA AAAGATGACA AGTAGAATCG GGAMTATrC TAAAGAATAG CCTGTAAGGT GTCCAGAAGC CACATTCTAG TCTrGAGTCT GCCTCTACCT GCTGTGTGCC cT-rGAGTACA cccTrAACCT CCT-rGAGCTT CAGAGAGGGA TAATCTrT ATTTTATTTT ATTYrATT GTT-[TGT GTIT~GTFTT G1TMATGAG ACAGAGTCTC ACTCTGTTGC CCAGGCTGGA GTGCAGTGGT ACAATCTTGG CT-rACTGCAT CCTCCACCTC CTGAGTTCAA GCGATTCTCC TTCCTCAGTC TCCTGAATAG CTAGGATTAC AGGTGCACCC CACCACACCC AGCTAATFT TGTAT1TTI7A GTAGAGAAGG GGTITTCGCCA TGT-rGGCCAG GCTGGTIrG AAGTCCTGAC CTAAATGATT CATCCACCTC GGCTTCCCAA AGTGCTGGGA TTACAGGCAT GAGCCACCAC GCCTGGCCCA GAGAGGGATG ATCTTTAGAA GCTCGGGATT CFTCAAGCC CTTCCTCCT CTCTGAGCT-r TCTACTCTCT GATGTCAAAG CATGGTTCCT GOCAGGACCA CCTCACCAGG CTCCCTCCCT CGCTCTCTCC GCAGTGCTCC TCCAGGACC TGGACCTCTG CCCTCTGGAT GGCGGCATCC AGCTACGAAT CTCCGACCAC CACTACAGCA AGGGCTTCAG GCAGGCCGCG TCAGTTG'rrG TGGCCATGGA CAAGCTGAGG AAGATGCTGG ITCCCTGCCC ACAGACCTTFC CAGGAGAATG ACCTGAGCAC CYUCT-rTCCC TTCATCTITG AAGAAGGTAG 17AGCCAAGA GCAGGCAGTA GATCTCCACT TGTGTCCTCT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT TCCCCCAGAG CCAAAGCCCT TTAAAGGTAG AAGGCCCAGC GGGGAGACAA AACAAAGAAG GCTGGAAACC AAAGCAATCA TCTCTTTAGT GGAAACTATT CTTAAAGAAG ATCTTGATGG 245 CTACTGACAT TTGCAACTCC CTCACTCTTT CTCAGGGGCC TTTCACTTAC ATTGTCACCA GAGGTTCGTA ACCTCCCTGT GGGCTAGTGT TATGACCATC ACCATTITAC CTAAGTAGCT CTGTTGCTCG GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TCTAATAGTG TCAGGTCCAG TGTTCT-rAGC CACCCCACTC CCAGCTTCAT CCCTACTGGT GTrGTCATCA GACTGACC GTATATGCTC AGGTGTCCTC CAAGAAATCA AATITTTGCCA CCTCGCCTCA CGAGGCCTGC CC11TCTGATT TTATACCTAA ACAACATGTG CTCCACATTfr CAGAACCTAT CTrCTTCGAC ACATGGGATA ACGAGGCTTA TGTGCACGAT GCACCTGTAC GATCACTGAA CTGCACGCTC CGGGACTCAC AGCAAAAAAG CTTGGTGATG TCTGGTCCAT ATGAACTGAA AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGTTT CCCTGCCTGG CCTCCTGGCA GCTTGCTAAT TCTCCATGTTr TTAAACAAAG TAGAAAGTTA ATTTAAGGCA AATGATCAAC ACAAGTGAAA AAAAATATTA AAAAGGAATA TACAAACTTT GGTCCTAGAA ATGGCACATT TGAYJTGCACT GGCCAGTGCA TTTGTTAACA GGAGTGTGAC CCTGAGAAAT CTCU-GGGCA TAGTGCAGTG TCAATTCTTC GTGGGTTCTC TCTTCCTGTT GTTGAGGCTG CCAGTCTTCC CCCC1TGCCC CAACATCCGT CGCCCAGCAG GAACUTATAT CTCTCCGCTG

CTGTGGTGAT

TGCTGAC1TT TTCTrGGAA

AAATGAGTGT

ACTCTCTGT-f

TUCCACATTG

TCCTfCCTTC CTGCCTGGCA TCGTGCCACA GAAGGACAGC CTCACTCAGG TCGGGTAGTA AGAGTGATCC CTCTCTTTGG AGCCACTTTC CCTGAAACAG TTCTGGTGCC ATCAAGTTGT TCCGCTCCTG CTTCAGCATT TAAAATGTAG

TAGACGGCTC

CACAATATGG

AAACAAGAGT

CCCACCCAAT

TAACGGGCAA

GTAGCCAAAG

GGGAAGCTAT

CAGGGCCTCC

CCAGCTCAGC

TGA1TUCTGG

TGGATGGGCA

ACCCTC1TTC

AAGCACTCCC

GGTCATTTGA

GCTGGAGCGA

GCCAGGTGGT

AAGTCAAG

CCTCTGCACA

TITGCTCTCAG

AATrGACACT

CTCTCCTCTC

CAGAAGTACA

CATTGCCAGC

A117CTCCGYT AGGACCATGT CCACCCAAGT TGGACATGGC CTAACTGCCT TAATGTGTCC ATCCCCCTCC TCCTTGTAGG GAAATTTTAC TGCGGTGAAC CCATCATTAG GGAGTGTGGG CAACTAAGGC CCAGGCCAAG AAAATCCTGT GCTGTGACTG AGGAAGATCA CCAGTTTCTT CCCATGGGCT GCTTCACCTC TTTCC'rrTCC CAGTGACACA ATGGCTTCCT CCTACTGCTA TGAGGCTCTG GCTATTGTCT GTGAGAAGTC GGCTACCAAT TACATGTATC CACAAGACCC CCT-rCTTTCT AATACCTGTG GCCTTGGGCC ACTCTACAGC TGGAGGTAAG CAGACAATTC ACCTTCTCCC CATTAATGTA AATAAATTTA TCATTGCC GATGTTATTA CTCATTTGAT AGACACCT-rG AATCACCACC ACTATCACCT AGAAACCCTC AGGCCTTTGA GGGGAAACCC

AAGT'TATCCT

CTACTCTCGG

TCAGTGGTGT

TCAAGGAAAA

TGAATGCTAT

CGCCCCCATC

ACATAATTTT

TGTCCTACCA

GTGTCTTAGG CCAAGGAACC GGCTAGGGGT TGGGGTGACC TAAATGAACA AAATGACCCT TCACTGTGGG TTCCCACAGA CTGCATGCTG TGTCCCTAAC TCTCCATGTC CTfTGTACAA GGAGAAGAAA GAATCTGTAC CTGTCCTGCG TGTTGAAAGA GGAATGAAGC CCYFCTCAGC CTCCTGCTAC CCTAGGAAAA GCTGGGAACA GGTCTAYITTG TAACTGCGTG CAACCTTCAA TCCTGCTGCA TAGTTACAAC CCCAACAGAT TATATATTGT

GTAATGACAA

TGATAAGCCC

CACTTATTCC

ACAAGTTTTG

GAAAATTAAA

TAGGGCTGCT

CCACTCCCAA GGAAATAGAT GACTFAAAGG GTCCCATTAT CACGTCCACT CCAGCTTTCT CAGCAAAAGC 7ITCATTCCA AGTTGATGTC ATCTAGGAC CATAAGGAAA AATACAATAA AAAGCCCCTG GAAACTAGGT ACTTCAAGAA GCTCTAGCTT AATTCACC CCCCCAAAAA AAAAAAATTC TCACCTACAT TATGCTCCTC AGCATI'TGGC ACTAAGTIT-T AGAAAAGAAG AAGGGCTCTT TTAATAATCA CACAGAAAGT TGGGGGCCCA GTTACAACTC AGGAGTCTGG CTCCTGATCA TGTGACCTGC TCGTCAGTTT CCMTCTGGC CAACCCAAAG AACATCTTTC CCATAGGCAT CTTTrGTCCCT TGCCCCACAA AAAT-rCTTCT TTCTCTTTCG CTGCAGAGTG TAGATCCCAA AAATTACCCA AAGAAGAAGA TGGAAAAGCG ATITGTCTTC AACAAGATAG AAATCAATAA CAAGCTGGAA TTTGAGTCTG CCCAGTTrCCC CAACTGGTAC ATCAGCACCT CTCAAGCAGA AAACATGCCC GTCTTCCTGG GAGGGACCAA AGGCGGCCAG GATATAACTG ACTTCACCAT GCAATITGTG TCTTCCTAAA GAGAGCTGTA CCCAGAGAGT CCTGTGCTGA ATGTGGACTC AATCCCTAGG GCTGGCAGAA AGGGAACAGA AAGGTTTTTG AGTACGGCTA TAGCCTGGAC T7TCCTGrG TCTACACCAA TGCCCAACTG CCTGCCTTAG GGTAGTGCTA AGAGGATCTC CTGTCCATCA GCCAGGACAG TCAGCTCTCT CC1TJTCAGGG CCAATCCCCA GCCCTTTTGT TGAGCCAGGC CTCTCTCACC TCTCCTACTC ACTTAAAGCC CGCCTGACAG AAACCACGGC CACATTTGGT TCTAAGAAAC CCTCTGTCAT TCGCTCCCAC ATTCTGATGA GCAACCGCTT CCCTATTTAT TTATTTATTT GTTTGTTTGT TrTGATTCAT TGGTCTAATTr TATTCAAAGG GGGCAAGAAG TAGCAGTGTC TGTAAAAGAG CCTAGTT-TT AATAGCTATG GAATCAATTC AAYITGGACT GGTGTGCTCT CTTTAAATCA AGTCCTITAA TTAAGACTGA AAATATATAA GCTCAGATTA ITFTAAATGGG AATAT1TATA AATGAGCAAA TATCATACTG TTrCAATGGTT CTGAAATAAA CTTCACTGAA GAAAAAAAAA AAAGGGTCTC TCCTGATCAT TGACTGTCTG GATTGACACT GACAGTAAGC AAACAGGCTG TGAGAGTTCT TGGGACTAAG CCCACTCCTC ATTGCTGAGT GCTGCAAGTA CCTAGAAATA TCCTTGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCTYF TATTTCGTTG T-rCAACAGAA GGATAT7CAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGGAG TCAGGACTGG TAGTAACAGC TACCATGATT TATCTATCAA TGCACCAAAC ATCTGTTGAG CAAGCGCTAT GTACTAGGAG CTGGGAGTAC AGAGATOAGA ACAGTCACAA GTCCCTCCTC AGATAGGAGA GGCAGCTAGT TATAAGCAGA ACAAGGTAAC ATGACAAGTA GAGTAAGATA GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GGAGGAGAAC GACATAAGAA TCAAGCCTAA AGGGATAAAC AGAAGATTTC CACACATGGG CTGGGCCAAT TGGGTGTCGG TITACGCCTGT AATCCCAGCA CTTTGGGTGG CAGGGGCAGA AAGATCGCTT GAGCCCAGGA GTTCAAGACC AGCCTGGGCA ACATAGTGAG ACTCCCATCT CTACAAAAAA TAAATAAATA AATAAAACAA TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAGCTAC TTrGGGAAGCT GACACTGGAG GATTGCTTGA GCCCAGAAGT TCAAGACTGC AGTGAGCT-rA TCCGTTGACC TGCAGGTCGA C-3' (FRAG. NO:_j(SEQ. ID NO:2512) TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGATTfCTCTT CAGCCAATCT TCAATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA TGGCTrATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CITCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGCT-rCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTf CCAGGAGAAT GACCTGAGCA CC1TCTCC CT17CATCTTT GAAGAAGAAC CTATCYI7CTT CGACACATGG GATAACGAGG 246 CTfATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CT'TGGGCCTC AAGGAAAAGA ATCTGTACCT GTGCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTI'GTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GfTTfTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTFAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCAGCCC T1TTGT-GAG CCAGGCCTCT CTCACCTCTC CTACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCCACAT TTTGG1TCTA AGAAACCCTC CTCTGTCATT CGCTCCCACA TTCTGATGAG CAACCGCTTC CCTATTfATT TATTrATTTG T-TGTTTGTT 17GATTCATT GGTCTAATTr A31TCAAAGGG GGCAAGAAGT AGCAGTGTCT GTAAAAGAGC CTAGTTThFA ATAGCTATGG AATCAAT-FCA ATTTGGACTG GTGTGCTCTC TrfTAAATCAA GTCCTYI7AAT TAAGACTGAA AATATATAAG CTCAGATTAT TTAAATGGGA ATATTTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC TTCACT-3' (FRAG. NO:J)(SEQ. ID NO:2513) TAGCAGCTGC CCCYrGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC AGACACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG AGCTTTCGCT TGCCGTCCAC CACTGCCCAC ACTGTCGTTT GCTGCCATCG CAGACCTGCT GCTGACTTCC ATCCCTCTGG ATCCGGCAAG GGCCTGCGAT TTTrGACAATG TCAAGATTTA CCGTATATCC CTG'TrGTr GGATACACCA GTGACGTCCA CT-rCTAGAAG ACAAAGTTAT ATTACTTAAA CAACCAAAGA TATGAAACTA TCCATGAAGA ACAATATTAT CAATACACAG CAGTCTTTTG TAACCATGCC CAATGTGATT GTACCAGATA TTGAAAAGGA AATACGAAGG ATGGAAAATG GAGGATGCAG CTCCTrTTCT GAGGATOATG ACAGTGCCTC TACATCTGAA GAATCAGAGA ATGAAAACCC TCATGCAAGG GG'FfCCTTfA GTTATAAGTC ACTCAGAAAG GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA 'FrGCCATTTT TAATGTGAAC AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGCGA-3' (FRAG. NO:J)(SEQ. ID NO:2514) TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGTGA AAATGAAGAA GACAGTTCCT CCATTGATCA TCTGTCTCTG AATCAGAAAT CCTTCTATCA TGTAAGCTAT GGCCCACTCC ATGAAGGCTG CATGGATCAA TCTGTGTCTC TGAGTATCTC TGAAACCTCT AAAACATCCA AGCTTACC11T CAAGGAGAGC ATGGTGGTAG TAGCAACCAA CGGGAAGGTT ATGATGACCT GGAGGCCATC GCCAATGACT C~rCCTGAGC AATGTGAAAT ACAACTTTAT AATCAAAGTA TAATTCGAGC CAATGATCAG TGAAATTTGA CATGGGTGCT TATAAGTCAT AAAAACTCAA TTGTATGTGA CTGCCCAAGA CCCAAAACCA TCACAGGTAG TGAGACCAAC TCACATCAGT TGCCCATCCA AACTTGTT-7A GCCACCCTCT ATCACTGACT TTCAGATACT TGTGCAGTGT TGACAGTTCA TATGTACCAT TGAGCATGTA CTGAGCCTTG TAATTCTAAA CATATAATGT TGTTATTTAA AGAACACCCT ATAACAATTT TAGGAGGACC AGAGCTACTG GCAAATrAAG GCATAAGAAA ACTAAGAAAT AT~rCATGAT TTCATTTCAA CTGTTTGCCT TAAGTTTCTG GGACCTCAGT TTTATCATTT CAGTTTT[TA TGCTAATCAG GGAGGTCATT CAAAGCACGA AATGTTAYrT TTAATTAT[ ATATACTATA TTTATGGGAA CCCCTTFCATC GTTCTGGG ATAAGTAAGT TTGATTTCAT GCCAGGAAAC TCTGCATTCT AGTACTTGGG AGCCAGTAAT TGGTCCGATC TTrGACTCTr TCCACCTGCA ATCAAGTCCT ACAAGCTAAA TCAAAACTT17 CTTTTCTGGA ATGTAATCAA GT-rACA31TAT TATCAACAAT AGTGATTGAT CTGAAGAAGA GACGGTTrGAG TTTAAGCCAA CAGAGGAAGA AATCATCAAG CCTAGGTCAG GAGGATCATC AAATACGAAT TCATCCTGAA TACCTCACGG CTGCTGCATT ACATAATCTG CAAAGGATGA TGCTAAAATT ACCGTGATTC TGAAGACCAA CCAGTGCTGC TGAAGGAGAT CTCCTCTTCT TCTGGGAAAC TCACGGCACT 31TGCCACAAA GCAAGACTAC TGGGTGTGCT GGAAAACCAG GCGTAGGTCT GGAGTCTCAC GTACATGAAG AAGCTAAATC CTTrACTGTT TGAATGTTTA CACTCTTrGT AAGAGTGGAA

TCCATCACTG

CACCTTTrAG

TGACGCCCTC

GATGAAGCAG

TAAGAATCTC

GCCTGAGATA

AAGAACTAT[

TGGCAGGGGG

TTGTCTCACT

AGTCATTTGC

CCAACACTAA

ATATTTrGCA TAGTACCAAT CATTTAATT ATTATTCTTC ACTATGGCTA CCAAAAAGAC ATGCACAATA GCAGTTGAAA TCTGCTTTTA AGT7GCTGAT TCAAAATGGA GGGAATAATA TrGGTAAAAT ACTTCTCGAA ATTTATATAT GTA'ITATAA CTCTGAGTGT GACCAGGCAT TAATACAGGG CAT]TTGGTC AGACCTGTAA TCATATAATA T-rGCCATTAA ACTTACCTGG AUTAGATGAA CTCAACTG TGTTTCTTCT AGGTTCTAAA AGAGTGTTAT CAGTCATAAC

TCTACCCATA

CAAGAAGCCA

GAACTCTTAA

CCTAAGCCT7

GCCGAGCCTC

ATATATTTAA

CCTCCACAAT

CAAGTTGTGC

AATGTACATT

GiCATTCTTGT

ACAACCATAG

AAT[GTGATC

TAAATAAAGC

TTACAGATGG

CAGACCTAGG

TCAAATAGCA

CCTGCCGCAA

AAGATGAAGG

GATAATTATA

AGCAGACAGT

TTATCCCATA

AATlACCTTG

TTCATTCAAT

ACCACTGTTFA

AGACCATAAT

TTGCAAGTGA

GGGAGTCATr TCAT-rGGCGT TTGAGTCAGC AAAGAAGTCA AG-3' (FRAG. NO:J)(SEQ. ID NO:2515) CAGAGAGGGA GTCATTTCAT TGGCGTTTGA GTCAGCAAAG AAGTCAAGAT GGCCAAAGTr CCAGACATGT TTGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA CAG'FrCCTCC ATTGATCATC TGTCTCTGAA TCAGAAATCC YI7CTATCATG TAAGCTATGG CCCACTCCAT GAAGGCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCTCTAA AACATCCAAG CTTAccT-rCA AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGGTTCT GAAGAAGAGA CGGTTGAGTr TAAGCCAATC CATCACTGAT GATGACCTGG 247 AGGCCATCGC CAATGACTCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CC=rrAGCT TCCTGAGCAA TGTGAAATAC AACTTTATGA GGATCATCAA ATACGAATTC ATCCTGAATG ACGCCCTCAA TCAAAGTATA ATTCGAGCCA ATGATCAGTA CCTCACGGCT GCTGCATTAC ATAATCTGGA TGAAGCAGTG AAATTTGACA TGGGTGCTTA TAAGTCATCA AAGGATGATG CTAAAATTAC CGTGATTCTA AGAATCTCAA AAACTCAATT GTATGTGACT GCCCAAGATG AAGACCAACC AGTGCTGCTG AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAACCT CCTCTJTCTTC TGGGAAACTC ACGGCACTAA GAACTATTTC ACATCAGTTG CCCATCCAAA CTTGTT[ATT GCCACAAAGC AAGACTACTG GGTGTGCTTG GCAGGGGGGC CACCCTCTAT CACTGACTTT CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCTCACT[F GTCTCACTTG TGCAGTGTTG ACAGUTCATA TGTACCATGT ACATGAAGAA GCTAAATCCT TTACTGTTAG TCATTTGCTG AGCATGTACT GAGCCTTGTA ATTCTAAATG AATGTTTACA CTCTTTGTAA GAGTGGAACC AACACTAACA TATAATGTTG 'rrATTTAAAG AACACCCTAT ATrTTGCATA GTACCAATCA TMTAATTAT TATTCTTCAT AACAATTrTA OGAGGACCAG AGCTACTGAC TATGGCTACC AAAAAGACTC TACCCATATT ACAGATGGGC AAATTAAGGC ATAAGAAAAC TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTCATGATTT CATTTCAACT GTTTGCCTTC TGCYI'TTAAG TrGCTGATGA ACTCTTAATC AAATAGCATA AGTfTCTGGG ACCTCAGTTT TATCATTC AAAATGGAGG GAATAATACC TAAGCCTTCC TGCCGCAACA GTTTTTTATG CTAATCAGGG AGGTCAT-TT GGTAAAATAC FUCTCGAAGC CGAGCCTCAA GATGAAGGCA AAGCACGAAA TGYITATTT'IT TAAT[ATTAT 'FrATATATGT ATTTATAAAT ATA'TFAAGA TAATTATAAT ATACTATATr TATGGGAACC CCTTCATCCT CTGAGTGTGA CCAGGCATCC TCCACAATAG CAGACAGTGT UTTCTGGGAT AAGTAAGTIT GATTTCATTA ATACAGGGCA TTTTGGTCCA AGTTGTGCT-r ATCCCATAGC CAGGAAACTC TGCATTCTAG TACTTGGGAG ACCTGTAATC ATATAATAAA TGTACATTAA TTACCTTGAG CCAGTAATTG GTCCGATCTT TGACTCTTTT GCCAUTAAAC 'I1TACCTGGGC A17CTTGTTT CATTCAATTrC CACCTGCAAT CAAGTCCTAC AAGCTAAAAT TAGATGAACT CAACTT7GAC AACCATGAGA CCACTGTTAT CAAAACTTTC TfT-CTGGAA TGTAATCAAT GTrFTCTTCTA GGTTCTAAAA ATI'GTGATCA GACCATAATG TTACATTATT ATCAACAATA GTGATTGATA GAGTG11TATC AGTCATAACT AAATAAAGCT TGCAACAAAA TrCTCTG-3' (FRAG. NO:J)(SEQ. ID NO:2516) Human Interleukin-1 Receptor (IL-i R) Nucleic Acids and Anti-sense Oligonucleotide Fragments GCTGGGTCTC AGTCCTCCAC TrCCCGTGTC CTCTGGAAGT TGTCAGGAGC AATGTTGCGC TTGTACGTGT TGGTAATGGG AGTTTCTGCC TTCACCCT7C AGCCTGCGGC ACACACAGGG GCTGCCAGAA GCTGCCGGTT TCGTGGGAGG CATTACAAGC GGGAGTTCAG GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC TGTCAGCCCC CGCATCAACC TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG AGAAGAAGAG ACACGGATGT GGGCCCAGGA CGGTGCTCTG TGGCTTCTGC CAGCC'ITGCA GGAGGACTCT GGCACCTACG TCTGCACTAC TAGAAATGCT TCTrACTGTG ACAAAATGTC CATTGAGCTC AGAGTTMTG AGAATACAGA TGCYT-CCTG CCGTTCATCT CATACCCGCA AA1TTTAACC TITGTCAACCT CTGGGGTATT AGTATGCCCT GACCTGAGTG AATTCACCCG TGACAAAACT GACGTGAAGA TrCAATGGTA CAAGGATTCT C'FrCT'FrTGG ATAAAGACAA TGAGAAATTT CTAAGTGTGA GGGGGACCAC TCAC11TACTC GTACACGATG TGGCCCTGGA AGATGCTGGC TATTACCGCT GTGTCCTGAC ATTTGCCCAT GAAGGCCAGC AATACAACAT CACTAGGAGT ATTGAGCTAC GCATCAAGAA AAAAAAAGAA GAGACCATTC CTGTGATCAT TTCCCCCCTC AAGACCATAT CAGCTTCTCT GGGGTCAAGA CTGACAATCC CGTGTAAGGT GTT-rCTGGGA ACCGGCACAC CCTrAACCAC CATGCTGTGG TGGACGGCCA ATGACACCCA CATAGAGAGC GCCTACCCGG GAGGCCGCGT GACCGAGGGG CCACGCCAGG AATATTCAGA AAATAATGAG AACTACAT-rG AAGTGCCATT GATTTTTGAT CCTGTCACAA GAGAGGATTT GCACATGGAT TTTAAATGTG TTGTCCATAA TACCCTGAGT TTTCAGACAC TACGCACCAC AGTCAAGGAA GCCTCCTCCA CGTTCTCCTG GGGCATTGTG CTGGCCCCAC TTrTCACTGGC CTrC'rrGGTT TTGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA CTGGAAAAGC AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT CAATCCTATC CCAAGTGAAA TAAATGGAAT GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAAA GCCGGAGCCG ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG GGAGCGGCAG GAATGTGACA ATCGCGCGCC CGCACCGTAG CACTCCTCGC TCGGCTCCTA GGGCTCTCGC CCTCTGAGCT GAGCCGGG1T CCGCCCGGGC TGGGATCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA CGCACCCTCT GAAGATGGTG ACTCCCTCCT GAGAAGCTGG ACCCCTTGGT AAAAGACAAG GCCT-rCTCCA AGAAGAATAT GAAAGTGTTA CTCAGACTTA T-rTGT-1rCAT AGCTCTACTG ATCTTCTC TGGAGGCTGA TAAATGCAAG GAACGTGAAG AAAAAATAAT TTTAGTGTCA TCTGCAAATG AAATTGATGT TCGTCCCTGT CCTCT'TAACC CAAATGAACA CAAAGGCACT ATAACTTGGT ATAAAGATGA CAGCAAGACA CCTGTATCTA CAGAACAAGC CTCCAGGATT CATCAACACA AAGAGAAACT 17GGTTGTT CCTGCTAAGG TGGAGGATTC AGGACATTAC TATTGCGTGG TAAGAAATTC ATCTTACTGC CTCAGAATTA AAATAAGTGC AAAAUTTGTG GAGAATGAGC CTAACT7ATG T-7ATAATGCA CAAGCCATAT TTAAGCAGAA ACTACCCGTT OCAGGAGACO GAGGACTTGT GTGCCCTfAT ATGGAGTTTT YI7AAAAATGA AAATAATGAG UTACCTAAAT TACAGTGGTA TAAGGATTGC AAACCTCTAC TTCTTGACAA TATACACTTT AGTGGAGTCA AAGATAGGCT CATCGTGATG AATGTGGCTG AAAAGCATAG AGGGAACTAT ACTTGTCATG CATCCTACAC ATACTTGGGC AAGCAATATC CTATTACCCG GGTAATAGAA YrTATTACTC TAGAGGAAAA CAAACCCACA AGGCCTGTGA 'rrGTGAGCCC AGCTAATGAG ACAATGGAAG TAGACTTGGG ATCCCAGATA CAATTGATCT GTAATGTCAC CGGCCAGTUG AGTGACAYTrG CTTACTGGAA GTGGAATGGG TCAGTAATTG ATGAAGATGA CCCAGTGCTA GGGGAAGACT ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGAGTAC CCTCATCACA GTGCTTAATA TATCGGAAAT 248 TGAAAGTAGA TTTTATAAAC ATCCATTTAC CTGYTfGCC AAGAATACAC ATGGTATAGA TGCAGGATAT

ATCCAGTTAA

TAATrGTGTG

CTATGATTTT

GTTGGGGAAG

AGTGTGGATA

TGAAAACGTA

GGTGGTTCAT

TYfGAGCTGGA

GGCTATCCGC

AGGTACCACA

AGAAACTGCA

TATATCCAGT

TTCTGTrTTC

CTCCCAATAA

GGTCTACCTC

TAAGCTGTTC

AAGAAAAGCA

CTGAAGAGCA

GAAAATCCAA

TGGTCAGGGG

TGCCAGTCCA

CACTAATTTC

ATCTATAAAA

AAGCTTCAGA

CAGAAGCACA

TCTTCAAGAT

TGGAAAGACC

TGACTGTGAT A1T=GTGT ATTTATGGAA GGGATGACTA GAAGACTGAT TATCATTTTA AATAGCCATG TATAATGCTC GACTATGAGA AAATGCCAGA ACTTTACACA GGACCACAG GCGACGGTCA CCTTCATCTA TGATTGGTAT ATGTGTCACG TGACATTGTG CTTTGGTACA TATGACGCAT ATATACTGTA TTAAAGTCTT GCCTGAGGTC CGTTGGGGAA GACATTGTUrG GTCAGAGAAA CATCAGGCTT TTGUTCAGGA TGGAATTAAA ATCGATrAAA TTCA11TAAGC TCTGCAAAGA CAAGGTTCTG AACACCAGTT ACTGTCACCA UfGACAGTCA

GGGATTCCTG

TCCAAAGACT

TrGGAAAAAC

AGGTCATTAA

CAGCTGGCTG

GTTGTCCTGC

AGAAACATGG

GAAGAATGTC

GCCACTAAGG

AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAGTT GCCAAGAGTT CTTTrAGGTGC CTCCTGTCT-F ATGGCG11TGC AGGCCAGGTT ATGCCTCATG CTGACTTGCA GAGTITCATGG TATCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG-3' (FRAG NO:j(SEQ. ID NO:2520) 5 '-GCCACGTGCT GCTGGGTCTC AGTCCTCCAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC

AATGTAACTA

AATGTTGCGC

TTGTACGTGT

GCTGCCGGTT

CCCCCAGGTG

TCTGCTAGGA

CAGCCTITGCA

CATTGAGCTC

TTGTCAACCT

TTCAATGGTA

TCAC'FrACTC

TGGTAATGGG

TCGTGGGAGG

CCCTACTGGT

CGGTCCCAGG

GGAGGACTCT

AGAGTT'flTTG

CTGGGGTATT

CAAGGATTCT

GTACACGATG

AGTTTCTGCC T-rCACCCYTC AGCCTGCGGC ACACACAGGG GCTGCCAGAA CATTACAAGC GGGAGTTCAG GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG TGTGGGCCTC TGTCAGCCCC CGCATCAACC AGAAGAAGAG ACACGGATGT GGGCCCAGGA GGCACCTACG TCTGCACTAC TAGAAATGCT AGAATACAGA TGC'TTrCCTG CCGTTCATCT AGTATGCCCT GACCTGAGTG AATTCACCCG CTTCTTfTOGG ATAAAGACAA TGAGAAATIT

TGGCCCTGGA

CACTAGGAGT GAAGGCCAGC AATACAACAT

CTGTGATCAT

GTT-FCTGGGA

GCCTACCCGG

AAGTGCCAT[

TACCCTGAGT

CTGGCCCCAC

CTGGAAAAGC

TTCCCCCCTC AAGACCATAT ACCGGACAC CCTTAACCAC GAGGCCGCGT GACCGAGGGG GA'FTYJTGAT CCTGTCACAA TI7TCAGACAC TACGCACCAC AGATGCTGGC TA'ITACCGCT ATTGAGCTAC GCATCAAGAA CAGCTTCTCT GGGGTCAAGA CATGCTGTGG TGGACGGCCA CCACGCCAGG AATATTCAGA GAGAGGATTT GCACATGGAT AGTCAAGGAA GCCTCCTCCA TGACATGGCA TAAAAATGAC CGGTGCTCTG TGGCTTCTGC TCT-rACTGTG ACAAAATGTC CATACCCGCA AATITTAACC TGACAAAACT GACGTGAAGA CTAAGTGTGA GGGOACCAC GTGTCCTGAC ATFI7GCCCAT AAAAAAAGAA GAGACCATTC CTGACAATCC CGTGTAAGGT ATGACACCCA CATAGAGAGC AAATAATGAG AACTACATTG TTTAAATGTG TFJGTCCATAA CGTTCTCCTG GGGCATTGTG UTTCACTGGC CT17CTTGGTT TTGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT CAATCCTATC CCAAGTGAAA TAAATGGAAT GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAAA (FRAG. NO:j)(SEQ. ID NO:2518) ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG TCGGCTCCTA GGGCTCTCGC CGGCCGTCCG TCCAGGTAGA AAAAGACAAG GCCTTCTCCA ATYTCTICTC TGGAGGCTGA GGAGCGGCAG GAATGTGACA ATCGCGCGCC CCTCTGAGCT GAGCCGGGTT CCGCCCGGGC CGCACCCTCT GAAGATGGTG ACTCCCTCCT AGAAGAATAT GAAAGTGTTA CTCAGACTTA TAAATGCAAG GAACGTGAAG AAAAAATAAT CCTCTfAACC CAAATGAACA CAAAGGCACT

CGCACCGTAG

TGGGATCCCA

GAGAAGCTGG

TTTGTTTCAT

TrTAGTGTCA

ATAACTTGGT

AAGAGAAACT

ATCTTACTGC

CAAGCCATAT

CACTCCTCGC

TCACCCTCCA

ACCCCTTGGT

AGCTCTACTG

TCTGCAAATG

ATAAAGATGA

TTGGTTTGTT

CTCAGAATTA

TTAAGCAGAA

AAATITGATGT

CAGCAAGACA

CCTGCTAAGG

AAATAAGTGC

ACTACCCGYT

TTACCTAAAT

AAGATAGGCT

ATACTTGGGC

AGGCCTGTGA

GTAATGTCAC

CCCAGTGCTA

GTGCTITAATA

ATGGTATAGA

ATGTGTCACG

CTrTGGTACA

ATATACTGTA

GCCTGAGGTC

GACATGTTG

CATCAGGCTT

TGGAATTAAA

TTCATTAAGC

CAAGGYTCTG

ACTGTCACCA

TCGTCCCTGT

CCTGTATCTA

TGGAGGATTC

AAAATTTGTG

GCAGGAGACG

TACAGTGGTA

CATCGTGATG

AAGCAATATC

'I17GTGAGCCC

CGGCCAGTTG

GGGGAAGACT

TATCGGAAAT

TGCAGCATAT

TTGACAGTCA

GGGATTCCTG

TCCAAAGACT

TTGGAAAAAC

AGGTCATTAA

CAGCTGGCTG

GTTGTCCTGC

AGAAACATGG

GAAGAATGTC

GCCACTAAGG

CAGAACAAGC CTCCAGGATT AGGACATTAC TATTGCGTGG GAGAATGAGC CTAACTI7ATG GAGGACTrGT GTGCCC'FrAT TAAGGATTGC AAACCTCTAC AATGTGGCTG AAAAGCATAG CTATTACCCG GGTAATAGAA AGCTAATGAG ACAATGGAAG AGTGACATTG CTTACTGGAA ATTACAGTGT GGAAAATCCT TGAAAGTAGA TT[TATAAAC ATCCAGTTAA TATATCCAGT TAATI7GTGTG TTCTGTITC CTATGA'rITr CTCCCAATAA

CATCAACACA

TAAGAAATTC

TTATAATGCA

ATGGAGTTTT TTAAAAATGA AAATAATGAG T-rCTTGACAA TATACACTTT AGTGGAGTCA AGGGAACTAT ACT-FGTCATG CATCCTACAC YJ7TATTACTC TAGAGGAAAA CAAACCCACA TAGACTTGGG ATCCCAGATA CAA17GATCT GTGGAATGGG TCAGTAATTG ATGAAGATGA GCAAACAAAA GAAGGAGTAC CCTCATCACA ATCCATTTAC CTGTUrTGCC AAGAATACAC CACTAATrTC CAGAAGCACA TGATTGGTAT ATCTATAAAA TCTTCAAGAT TGACATTGTG AAGCTTCAGA TGGAAAGACC TATGACGCAT GTTGGGGAAG GGTCTACCTC TGACTGTGAT ATTIJGTGT TTAAAGTCTT AGTGTGGATA TAAGCTGTTC AITI7ATGGAA GGGATGACTA TGAAAACGTA AAGAAAAGCA GAAGACTGAT TATCATTTTA GGTGGTrCAT CTGAAGAGCA AATAGCCATG TATAATGCTC TTGAGCTGGA GAAAATCCAA GACTATGAGA AAATGCCAGA GGCTATCCGC TGGTCAGGGG ACTTTACACA GGGACCACAG AGGTACCACA TGCCAGTCCA GCGACGGTCA CCTTCATCTA AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA

CGTTGGGGAA

GTCAGAGAAA

TTGTTCAGGA

ATCGATfAAA

TCTGCAAAGA

AACACCAG'17

TGGAGAAGTT

GCCAAGAGY[ CTTTAGGTGC CTCCTGTCTT ATGGCGTTGC AGGCCAGGTT ATGCCTCATG CTGAC~rGCA GAGTTCATGG AATGTAACTA TATCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG-3' (FRAG. NO:J)(SEQ. ID NO:2519) Human Interleukin-8* Fragments Antisense Oligonucleotide Fragments 249 BCCBBBGCBT CBBGBBTBGC TTTGCTBTCT BBGGBTCBCB 1T1GBCBTB GGBBBBCGCT GTBGGTCBGBB BGBTGTGCTT BCCTTCBCBC BGBGCTGCBG BBBTCBGGBBGG CTGCCBBGBGBG CCBCGGCCBGC TTGGBGTCBT GTTTBCBCBC BGTGBGGTGC TCCGGTGGCT 1TfTGCTTGT GTGCTCTGCT GTCTCTG TTC CTTCCGGTGG TTTCTTCCTG GCTCTTGTCC TTTCTCYFGG CCCTTrGGCCC-3' (FRAG. NO:1834) (SEQ. ID NO:1847) CTC CGG-3' (FRAG. NO:1835) (SEQ. ID NO:1848) 5'-CBBGBBTBGC-3' (FRAG. NO:1836) (SEQ. ID NO:1849) BGTGBGGTGC-3' (FRAG. NO:1837) (SEQ. ID NO:1850) CBBGBBTBGC-3- (FRAG. NO:1838) (SEQ. ID NO:1851) 5.-GCCBBGBGBG CCBCGGCCBGC-3' (FRAG. NO:1839) (SEQ. ID NO:1852) CTC CGG TGG CTT TTT-30 (FRAG. NO:1289)(SEQ. ID NO:1298) TGT GTG CTC TGC TGT CTC TO-3D (FRAG. NO:1290)(SEQ. ID NO:1299) CTT CCG GTG GUT TCT TCC TGG CTC TTG TCC T-30 (FRAG. NO:1291)(SEQ. ID NO:1300) TCT TGG CCC T-FG GCC C-31i (FRAG. NO:1292)(SEQ. ID NO:1301) 5.-GBTGTTTGTT BCCBBBGCBT CBBGBBTBGC T-FTGCTBTCT BBGGBTCBCB TI7TBGBCBTB GGBBBB3CGCT GTBGGTCBGBB BGBTGTGCTT BCCTrCBCBC BGBGCTGCBG BBBTCBGGBBGG CTGCCBBGBGBG CCBCGGCCBGC TTGGBGTCBT GTTTBCBCBC BGTGBGGTGC TCCGGTGGCT TTTTGCTTGT-3' (FRAG. NO:1840) (SEQ. ID NO: 1853) Human IL-8 Receptor Alpha Antisense Oligonucleotide Fragments 5'-ACAGGGGCTG TAATCTTCATC TGCAGGTGGC ATGCCAGTGA AATTTAGATC ATCAAAATCC CACATCTGTG GATCTGTAAT ATrTGACATG TCCTCTTCAG TTI'CAGCAAT GGTTTGATCT AACTGAAGCA CCGGCCAGGB CBGGGGCTGT BBTCTTCBTC TGCBGGTGGC BTGCCBGTGB BB'TTDGBTC BTCBBBBTCC CI3CBTCTGTG GBTCTGTBBT BTTBCBTG TCCTCTTCBG TTTCBGCBB TGGTJ7TGBTC TBBCTGBBGC BCCGGCCBGG TGGCTCGGTG CTTCTGCCCC TGTTGTTGCG GCGCTCGGTT GGTGTGGCCC CTGTGGTGCT TCGTrTCCCC CTCTTTCTCT TTGTTCGGGG GTTCTTGTGG CGGGCTGCTTr GTCTCGTTCC-3'(FRAG.NO:1841)(SEQ. ID NO:1854) 5'-CBGGGGC-3- (FRAG. NO:1842) (SEQ. ID NO:1855) 5'-GCBGGTGGC-3' (FRAG. NO:1843) (SEQ. ID NO:1856) 5'-GCGGCGCTC-3' (FRAG. NO:1844) (SEQ. ID NO:1857) (FRAG. NO:1 293)(SEQ. ID NO: 1302) 5'-TGTTGTTGCGGCGCTC (FRAG. NO:1294)(SEQ. ID NO:1303) (FRAG. NO:1 295)(SEQ. ID NO:1304) (FRAG. NO:I 296)(SEQ. ID NO:1305) (FRAG. NO:1297)(SEQ. ID NO:1306) 5'-GGGGGTJ7CTTGTGGC (FRAG. NO:1298)(SEQ. ID NO:1307) 5'-GGGCTGCTTGTCTCGTTCC (FRAG. NO:1299)(SEQ. ID NO:1308) TAATCTTCATC TGCAGGTGGC ATGCCAGTGA AATTTAGATC ATCAAAATCC CACATCTGTG GATCTGTAAT ATTGACATG TCCTCTTCAG TCAGCAAT GGTYJTGATCT AACTGAAGCA CCGGCCAGG-3' (FRAG. NO:1845) (SEQ. ID NO:1858) CBGGGGCTGT BBTCTTCBTC TGCBGGTGGC BTGCCBGTGB BB'TrTBGBTC BTCBBBBTCC CBCBTCTGTG GBTCTGTBBT BTT-rGBCBTG TCCTCTTCBG TTTCBGCBB TGGTTTGBTC TBBCTGBBGC BCCGGCCBGG-3 (FRAG.

NO: 1846) (SEQ. ID NO: 1859) Interleukin-il (IL-1l) Nucleic Acid and Antisnese Oligonucleotide Fragments CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC CTGGCCCTGT GGGGACATGA ACTGTGTTTG CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG GCCAGATACA GCTGTCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGTFI7 CCCCAGACCC TCGGGCCGAG CTGGACAGCA CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA GCTGGCTGCA CAGCTGAGGG ACAAAT1TCCC AGCTGACGGG GACCACAACC TGGATTCCCT GCCCACCCTG GCCATGAGTG CGGGGGCACT GGGAGCTCTA CAGCTCCCAG GTGTGCTGAC AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCACGTG CAGTGGCTGC GCCGGGCAGG TGGCTCTTCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GOGCCGCCCA CGCCATCCTG GGGGGGCTGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTGCT GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CCTrCCAAAG CCAGATCTTA TrTA1IATT TATTTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCATTIATCT CCCCCTAGTT AGAGACAGTC CTTCCGTGAG GCCTGGGGGA CATCTGTGCC TTATTTATAC TTAmTTYF CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG GGACTGGGGT CCCGGATTCT TGGGTCTCCA AGAAGTCTGT CCACAGACTT CTGCCCTGGC TCTJTCCCCAT CTAGGCCTGG GCAGGAACAT ATATITATTiTA TAAGCAAT TACTITTCAT GYTGGGGTGG GGACGGAGGG GAAAGGGAAG CCTGGGTTT TGTACAAAAA TGTGAGAAAC CTITTGTGAGA CAGAGAACAG GGAATTAAAT GTGTCATACA TATCC CAGCTGCGGC ATCCTCTGTC TCAGAGTC'rr GGTGTCTCTG 11TCCTTTCCC CTCGGGGTCT CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CTrCCTCCCG CTCTCTGATC TCTGACTCCC AGAACCTCTC CCTCTGTCTC 250

CAGGGCTGCC

CCGTCTCCCT

TTFCCCU-CCA

TCTCTGCCTT

AGTCGGGCCC

ACCTCACCAG

CTCCTCCGAG

GGGTGAGTCA

TATATAACCC

TCCCCAGCCG

GGCTCCCTGC

CCTCTGATCC TCYI'TGCTTC TCTGGTGTGT CTCTCTGGCT GCCTCCATCT GTCTCTGTCT CAGTCTGTCC YfCACTCTGT GTGTGTGTGT GTCTCTCTCT CTCCCTCTTC CTCCTGCCTC CACCTCTCCA GGCCCCTGTC TTGTCCCTCC TCCGTCCTCC TGCCTCCCCA TCTCTCTCTG CTAGTCCTGT CCAGCCGGAC CAGCGCTTGA GCCTGAGTGT CTGCTCCGGC CCGTGGAGGT GGAGGGAGGG CCCCTCTCCG ACCACCCCCC CCYI17CCC1T TTCAACUTTT CCAACTTTfC CGCGGCGGCG TGAGCCCTGC AAGGCAGCCG CTCCGTCTGA ATGGAAAAGG GGATGTGTCA GGCCGGCCCT CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCCAGGCGTC CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGTT CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGTTG

CTGTGGATCT

CTCTCTCTCC

GTCCGGCCT

CCCCACCCAC

GACGCCAATG

CTTCCGTGCC

CAGGCAGGGA

CCAGGCCCCC

ATGCCTCCCC

AAAGGCCCCC

GTT7CATGGGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT GOGAGGAGAC CCCGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG AGCAGCTFCG GAGACAGGAG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC GGATGGAGGC AGCCAATCAG AGGCGCCGCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGATTCCGG CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGAAAGCG GGGAGAGCCG GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGGGC TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGATT GGCTGGCGGG TGGCCGGGTG GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCGGGCC ATGGCTCTGC CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG GCTJTCTGCCG CCCACCCGGC GGGCTCCTGG GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCTGGGC TTTTGGCTCC TTCCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG GTrCTGGCCT GTGCCTCCCC CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG GCGGACGGGA GACGCCCGGG CCGCGTCTGC TCCGACGGGC GGGGCAGCCA GAGCCAGGGA GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGCCCGCGG GCGTTCCACC CTGGGACTTA AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG CCCCAGACCC TCCTCCCCGA GACCCAGGAG TCCAGACCCC AGGCCTTCCT CCCTCAGACC TAGGAGTCCA GGCCCCCAGC CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGT7 CCTCCTCCCT CAGACCCGGG AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCC17ATC CTGCCCCCAG GTGTFTGCCG CCTGGTCCTG GTCGTGCTGA GCCTGTGGCC AGATACAGCT GTCGCCCCTG GGCCACCACC TGGCCCCCCT CGAGTTTCCC CAGACCCTCG GGCCGAGCTG GACAGCACCG TGCTCCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT GGCTGCACAG CTGGTAGGAG AGACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG GAGTCTGCGG GCAGCCACTT GGAGGGGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG GAAGAGTTGG GGGCCTGGCG TGGGGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC TCACAGCTTT TTITCCCTGCC AGAGGGACAA ATTCCCAGCT GACGGGGACC ACAACCTGGA 'rrCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC ACTGGTCGGG TGTTCTCTGA TGTCCCGGCT CTATCCCCAG CTCCCAGGTG TGCTGACAAG GCTGCGAGCG GACCTACTGT CCTACCTGCG GCACGTGCAG TGGCTGCGCC GGGCAGGTGG CTCTTCCCTG AAGACCCTGG AGCCCGAGCT GGGCACCCTG CAGGCCCGAC TGGACCGGCT GCTGCGCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG ACCTGACACC CCAGACCCCC ACCCCTGGCC CCAAAATCCT GTGGCCTGAG TCCTTGAAGC CTGAGACCCC AGACCCGAGT GCAACAGCCC CGCTCTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC CCTGACACCG TAACAGCCCC GCTCTGAGAC CCTGACCCTA ACAGTCCTGC TCTGAGACCC TGACCCTGCA GTCCCAAGAT CCTGTGGCCC TGAGACCCTG AGGCCCTAGA CCCCCAAATC CTGCCCAGAA ACTTCAAATT CTCACCCAAG ACCCTGAGAC TCCATCATCC ATGACCTCAA AGTCCCCAGA TCCCAGCCCC TAAGACCCAA GACCCCATCC TGAAGCCCAA AGCCTTGAGA ATfTCAAATCC TCACCTCAAG ACTTGGAGAC CCTGGCCCCA TGACATTGAA AACCATGGAC CTGGCCAGGC GTGGTGGCTC ACGCCTGTAA TCCCAGCACT TTGGGAGGCC GAGGCAAGTG GATCACCTGA GGTCGGGAGT TCAAGACCAG CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC AAAATTAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CTACTTGGGA GGCTGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCATITACAC TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAAA AAGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAGGCCCC AGCCCTGAGA TCCTGACATC TTAAAGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA AGCCAGCCTrF GGGACCCTGG CTGTACAAAC CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT ATGTCTCACT CCCAACATCG AAAACCCTGA CACCTCAGAT CCTGAGCCTG CGCCTGTACG ACTCCAAGAC CCTCACTTCC AAAGCCAGGC CCAAAGCCCT GAGACCAGAA GACTTCAAAC CCTGGTTCTr GGGCCTAACT CCAAAGACCC TGGATCTCAA ATTCCAACTT CTAGCTCTGA GACTCCAGCC CTCACCCATG AGTTrCCTGAA CTTGAACCCA GAGACCCCAT 251 CTCTAAGACT TCAGCCUTGA GATCCAGGGC GTAAAACCCC AGCTCTGGTG GGGAGCAGTG AAGGACCTCT TGAGGCCATG AGYITGAGAC TT1A'FfATTAT TATTTTTOG AGACAGAGTC TCGGCTI'GCT GGAACCTCCG CCTCCTGGGC CTFCAGGTGC ACACTGCCAC ACCCGGATAA CCCAGGCTGG TCACAAACTC CTGAGCTCAG AGGCGTGACG CCGCGCCTGG CTTCTTAATT ATTCCAGCCC CGGCGACTCT AACAGTCCCA TCCACAGACT TCACCCCCAA CCCCCACACT GAACCCCACA GCCTGAAGAG CTCCCGGCCT GCAGCCCCGA TTCAGCTGCA GCTCCACAGC TCACCTCTCT CCTCTCCCCA CAGATGTCCC CCCGCTGGCG CCCCCCTCCT CAGCCTGGGG CTGACACTTG ACTGGGCCGT GAGGGGACTG ACCACCGTCC TTCCAAAGCC AGATCTrATT ATCCCCCCGC CATTATCTCC CCCTAGTTAG ATTTATACTT ATTJ7ATTTCA GGAGCAGGGG ACTGGGGTCC CGGATTCTTG GGTCTCCAAG AGGCCTGGGC AGGAACATAT ATTATTTATT AAGGGAAGCC TGGGTrTTG TACAAAAATG GTCATACATA TCCACTTGAG GGCGATTTGT CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT GCTCACTCCT GTAATCCCAA GGCAGGGGAG GCCAAGGCAG AGCCTGGGCA GCATAGCAAG ACTCTGTTTC TTAAYITATTA

TCGCGCTCTG

TCAAGCGATT

TTTTTTGTA

GCCATCCGCC

GTTCTAACAG

GGCCCGATCC

CAGCTCTGGA

AAACACTTCA

ACCCCTGCCC

GCCTGGCCCT

GGGCATCAGG

CTGCTGCTGA

TATTTATTTA

AGACAGTCCT

rGGGAGGCAG

AAGTCTGTCC

TAAGCAATTA

TGAGAAACCT

CTGAGAGCTG

TTGCCCAGGC

CTCCTGCCTC

TTTTAGTAGA

CGCCTCGGCC

CAGCGACAAC

CTCACCTAGA

AGCCCGTCCT

CCCCACGCGC

TGCACCCCCG

TAGAGTGCAA

AGCCTCCTGA

CACAGGGTTTr

TCCCAAAGCG

AACAAAAACC

ACCGAGATGC

GACTCCAGCC

CACAGTCCCC

CTGCACCCCC

TGGTGCCATf

GTAGCTGGGA

CACCGTGTTG

CTGGGATAAC

CAGCTCTGAG

CAGCCCTGAC

TCCATT-rTCG

CTGTGAATAT

TACCTGTGAC

GCCCCAGCCA CCCCCGGACC CGCCGGCGCC GCCGCCCACG CCATCCTGGG GGCTGCAC AGACTCGGCT GTGACCCGGG GCCCAAAGCC TrTCAGTACT GGGGGCGAAA CAGCCAGGTG TCCGTGAGGC CTGGGGGGCA TCTGTGCCTT GTGGACTCCT GGGTCCCCGA GGAGGAGGGG ACAGACTrCT GCCCTGGCTC TTCCCCATCT CT1TITCATGT TGGGGTGGGG ACGGAGGGGA CAGGTGGAGG GGAGACCTCC GTCACCCAGA CAGCTCTGTG GTT7GTTTTT TGAGATGGAG GCAACCTCCA CCTCCCGGGT GCACCACCAT GCCCAGCTAA CCAGGCTGGT TTCGAACTCC GGTGTGAGCC ACCACACCTG GTGATCAACA GTACCCGTAT GCAAACTGGA AACAATCTAG CACCCAGCCG CCCGGAGCAG AGATATCCTG ACATTGGCCA GTGGATCACT GAAGTCCAAG AGAATGATGT CCTGACATGA ATTCAGGTGG AGGTCCCGAG GAGGCAGGGT CTGAGCCTTG TCTCGCTCTG TrGCCTAGGC TCAAGCAATT CTCCTGCCTC TTATTTATTT CTTTGTATI' TGACCTCAGG TGATCCTCCT ACCCATAGGT CTTCAATAAA GGGACAAAGC TGCAAGGTCA ATATCCAACA GTGAGGGTTA GGACTGTCAT TCAGGGAGGC

TTGTGAGACA

GGGCTGGATG

TGGGCGGGGC

CCTGGGGCCC

TGGAGTGCAG

AGCCTCCCGA

TTTAGTAGAG

GCCTCGGCCT

TA'FrAATGG

AGATGGTTCA

AGCAACATGG

TAAGGAGAGA

GAGAACAGGG AATTAAATGT CYITGGGTAAC TGGGGCAGGG AGCGACTGGG AGATGGGTCG CGCACTGCAT AGGGCCGTTT TGAGGCAATC TAAGGTCACT TrAGCTGGGA TCACAGGTGT ACAGGGTT-rC ACCATGTTGG CCCAAAGTGC TGGGATTACA AAGGFITCCAC AAGTCACCCT TTATGGCTGT GTTCACCATA TGCATCTGTG GATAGAACGC GGCTTGCTTG GGATATAGAA GGCATGGTGG CTCACGCCTG TAATCCTGGC ACTTTGGGAG GACGAAGCGA AGTTTGAGAC CGGCCTGCGA GACATGGCAA AACCCTGTCT CAAAAAAGAA AACAGCAGGC TACAAAACCA CTGCATGCTG TGATCCCAAT TTTGTGTTTT TCTTTFCTATA TATGGATTAA AACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTTGACAA TGACTGTCTC CAGGTCAAAG GAGAGAGGTG GGATTGTGGG TGACTTTTAA TGTGTATGAT TGTCTGTATT TTACAGAATT TCTGCCATGA CTGTGTAT TGCATGACAC ATTTTAAAAA TAATAAACAC TATTTTAGA ATAACAGAAT ATCAGCCTCC TCCTCTCCAA AAATAAGCCC TCAGGAGGGG ACAAAGTTGA CCGCTGATTG AGCCTGTCAG GGCTGTGCAC-3' (FRAG. NO:J(SEQ. ID NO:2523) CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC CTGGCCCTGT GGGGACATGA ACTGTGTTTG CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG GCCAGATACA ACCTGGCCCC CCTCGAGYT- CCCCAGACCC TCGGGCCGAG CTGGACAGCA CTCCTGGCGG ACACGCGGCA GCTGGCTGCA CAGCTGAGGG ACAAAYJTCCC TGGATTCCCT GCCCACCCTG GCCATGAGTG CGGGGGCACT GGGAGCTCTA AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCACGTG CAGTGGCTGC CTGAAGACCC TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG TCCTGATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA CCCGCCGGCG CTCAGCCTGG GGGGGCATCA GGGCCGCCCA CGCCATCCTG GGGGGGCTGC GTGAGGGGAC TGCTGCTGCT GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCAGATCTTA TATTTATU TATTITCAGTA CTGGGGGCGA AACAGCCAGG

GCTGTCGCCC

CCGTGCTCCT

AGCTGACGGG

CAGCTCCCAG

GCCGGGCAGG

GCTGCTGCGC

CCCCCGCTGG

ACCTGACACT

CCACCACCGT

TGATCCCCCC

CTGGGCCACC

GACCCGCTCT

GACCACAACC

GTGTGCTGAC

TGGCTCTTCC

CGGCTGCAGC

CGCCCCCCTC

TGACTGGGCC

CCT-CCAAAG

GCCATrATCT CCCCCTAGTT AGAGACAGTC CTTCCGTGAG GCCTGGGGGA CATCTGTGCC TTATTTATAC TTATTTATTT CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGO GGACTGGGGT CCCGGATrCT TGGGTCTCCA AGAAGTCTGT CCACAGACTT CTGCCCTGGC TC~rcCCCAT CTAGGCCTGG GCAGGAACAT ATATTATTTA TTrAAGCAAT TACTrCAT GT-rGGGGTGG GGACGGAGGG GAAAGGGAAG CCTGGGTTTT TGTACAAAAA TGTGAGAAAC CTTTGTGAGA CAGAGAACAG GGAATTAAAT GTGTCATACA TATCC (FRAG.

NO:J(SEQ. ID NO:2521) -CAGCTGCGGC ATCCTCTGTC TCAGAGTCTT GGTGTCTCTG TrccTT~CCC CTCGGGGTCT CCCTGGGTCT 252

CCCCAAGTCC

CAGGGCTGCC

CCGTCTCCCT

TTCCCT-rCCA

TCTCTGCCTT

AGTCGGGCCC

ACCTCACCAG

CTCCTCCGAG

GGGTGAGTCA

TATATAACCC

TCCCCAGCCG

GGCTCCCTGC

AGGGTGGAGG

CGCACAGAGA

AGATGGGCAG

GCCAGACAGG

CTCCTGCTGT

CCTCTGATCC

GTCTCTGTCT

CTCCCTCTTC

TCCGTCCTCC

CAGCGCYTFGA

CCCCTCTCCG

CGCGGCGGCG

GGATGTGTCA

CCCAGGCGTC

CGGGCCCAGC

CTrFCCTCCCG TC1TI'GCTTC

CAGTCTGTCC

CTCTCTGATC

TCTGGTGTGT

TTrCACTCTGT

TCTGACTCCC

CTCTCTGGCT

GTGTGTGTGT

CTCCTGCCTC CACCTCTCCA GGCCCCTGTC TGCCTCCCCA TCTCTCTCTG CTAGTCCTGT GCCTGAGTGT CTGCTCCGGC CCGTGGAGGT ACCACCCCCC CCTTTCCCTT TTCAACTTTT TGAGCCCTGC AAGGCAGCCG CTCCGTCTGA GGCCGGCCCT CCCCTGCCGC CTGCCCCCCG CACACTCCCT CACTGCCGCG GGCCCTGCTG TGACCCTCGG GGCTCCCCCG GCAGCGGACA

AGAACCTCTC

GCCTCCATCT

GTCTCTCTCT

TTGTCCCTCC

CCAGCCGGAC

3GAGGGAGGG

CCAACTTITC

\LTGGAAAAGG

CCCGCCCGCC

CTCAGGGCAC

GGGAAGGGTT

CTGTAAGTTG

CCTCTGTCTC

CTGTGGATCT

CTCTCTCTCC

GTCCGGCCT[F

CCCCACCCAC

GACGCCAATG

CTTFCCGTGCC

CAGGCAGGGA

CCAGGCCCCC

ATGCCTCCCC

AAAGGCCCCC

GTTCATGGGG CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT GGGAGCAGAC CCCGCTGAGT GGGACCCGGA GACAGGCAGC CGGGGAGGAGJ AGCAGCTTCG GAGACAGGAG GCGGCGGAGG AGAGAGACAC AGACAGGAGC GGATGGAGGC AGCCAATCAG AGGCGCCGCA GGAGGGACGG GCCCGAGAGG AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGATTCCGG CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGAAAGCG GGGAGAGCCG GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGGGC TGGGGGTGTG AGCGCTGATT GGCTGGCGGG TGGCCGGGTG GGCGGGGCGG CCGGGGTGGG ACCCCCGCGC CCCCGGCGCC CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC ATGGCTCTGC CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG GCT"TCTGCCG GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC 17CCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG GCGGACGGGA TCCGACGGGC GGGGCAGCCA GAGCCAGGGA GGGAGAGGGA AGCCCGCCTG GCGTTCCACC CTGGGACTTA AGACCTCCAG CTCCATCCTC CCTAAGGCCG TCCTCCCCGA GACCCAGGAG TCCAGACCCC AGGCCTTrCCT CCCTCAGACC CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGTI' CCTCCTCCCT AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCC1TATC CCTGGTCCTG GTrCGTGCTGA GCCTGTGGCC AGATACAGCT GTCGCCCCTG CGAGT-FTCCC CAGACCCTCG GGCCGAGCTG GACAGCACCG TGCTCCTGAC CGCGGCAGCT GGCTGCACAG CTGGTAGGAG AGACTGGGCT GGGGCCAGCA GAACGGAGAG GAGTCTGCGG GCAGCCACTT GGAGGGGTTC TGGGCTCTCA CGAGGCGCGG GCGGCCGGGG CTGCGGGGAG CGAGCTCCGG TCCCGGCGCC CGGCCGGGCC CCCACCCGGC GGGCTCCTGG CGTCCTGGGC TTT7GGCTCC GTTCTGGCCT GTGCCTCCCC GACGCCCGGG CCGCGTCTGC GCCCTGCGAC CTGCCCGCGG GGAGTCCAGG CCCCAGACCC TAGGAGTCCA GGCCCCCAGC CAGACCCGGG AGTCCAGCCC CTGCCCCCAG GTG1TTGCCG GGCCACCACC TGGCCCCCCT CCGCTCTCTC CTGGCGGACA CAGGAGTGAG AGGCAGAGAG G3GTGGCAGAG TGAGGGAGGG GAAGAGTTGG GGGCCTGGCG TGGGGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC TCACAGCTTT TrTCCCTGCC AGAGGGACAA ATTCCCAGCT GACGGGGACC ACAACCTGGA TJTCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC ACTGGTCGGG TGTTCTCTGA TGTCCCGGCT CTATCCCCAG CTCCCAGGTG TGCTGACAAG GCTGCGAGCG

GGGCAGGTGG

GCTGCGCCGG

CCAAAATCCT

CCCTGACACC

ACAGTCCTGC

CCCCCAAATC

AGTCCCCAGA

TCACCTCAAG

ACGCCTGTAA

CTCTTCCCTG AAGACCCTGG

CTGCAGCTCC

GTGGCCTGAG

CTAACAGCCC

TCTGAGACCC

CTGCCCAGAA

TCCCAGCCCC

ACTTGGAGAC

TGGTATGTCC

TCCTTGAAGC

GCTCTGAGAC

TGACCCTGCA

ACTTCAAATT

TAAGACCCAA

CCTGGCCCCA

GACCTACTGT

AGCCCGAGCT

TGGCCCCAAG

CTGAGACCCC

CCTGACACCG

GTCCCAAGAT

CTCACCCAAG

GACCCCATCC

TGACATTGAA

CCTACCTGCG GCACGTGCAG GGGCACCCTG CAGGCCCGAC ACCTGACACC CCAGACCCCC AGACCCGAGT GCAACAGCCC TAACAGCCCC GCTCTGAGAC

TGGCTGCGCC

TGGACCGGCT

ACCCCTGGCC

CGCTCTGAGA

CCTGACCCTA

CCTGTGGCCC TGAGACCCTG AGGCCCTAGA ACCCTGAGAC TCCATCATCC ATGACCTCAA TGAAGCCCAA AGCCTTGAGA ATTCAAATCC AACCATGGAC CTGGCCAGGC GTGGTGGCTC GATCACCTGA GGTCGGGAGT TCAAGACCAG AAAATTAGCC AGGCGTGGTG GTGCATGCCT TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA TCCCAGCACT TTGGGAGGCC GAGGCAAGTG CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC GTAATCCCAG CTACTTGGGA GGCTGAGGCA GGAGAATCGC CCGAGATCGC ACCATTACAC TCCAGCCTGG GCAACAAGAG AAAAAAAAAA AAGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAGGCCCC AGCCCTGAGA TCCTGACATC TTAAAGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA AGCCAGCCTT GGGACCCTGG CTGTACAAAC CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT ATGTCTCACT CCCAACATCG AAAACCCTGA CACCTCAGAT CCTGAGCCTG CGCCTGTACG ACTCCAAGAC CCTCACTTCC AAAGCCAGGC CCAAAGCCCT GAGACCAGAA GACTTCAAAC CCTGGTTCTT GGGCCTAACT CCAAAGACCC TGGATCTCAA ATTCCAACTT CTAGCTCTGA GACTCCAGCC CTCACCCATG AGTTCCTGAA CTTGAACCCA GAGACCCCAT CTCTAAGACT TCAGCCYUFGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT GTAAAACCCC AGCTCTGGTG GGGAGCAGTG GCTCACTCCT GTAATCCCAA GGCAGGGGAG GCCAAGGCAG AAGGACCTCT TGAGGCCATG AGYT-GAGAC AGCCTGGGCA GCATAGCAAG ACTCTGT17C TTAATTATTA TYFATTATTAT TATTTTTGG AGACAGAGTC TCGCGCTCTG TTGCCCAGGC TAGAGTGCAA TGGTGCCATT TCGGCTITGCT GGAACCTCCG CCTCCTGGGC TCAAGCGA1T CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CYFCAGGTGC ACACTGCCAC ACCCGGATAA TTTTTGTA TTTTAGTAGA CACAGGGTTr CACCGTGTTG CCCAGGCTGG TCACAAACTC CTGAGCTCAG GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGATAAC AGGCGTGACG CCGCGCCTGG CTTCTrAATT G117CTAACAG CAGCGACAAC AACAAAAACC CAGCTCTGAG ATTCCAGCCC CGGCGACTCT AACAGTCCCA GGCCCGATCC CTCACCTAGA ACCGAGATGC CAGCCCTGAC 253 TCCACAOACT TCACCCCCAA CCCCCACACT CAGCTCTGGA GAACCCCACA GCCTOAAOAG CTCCCOOCCT AAACACTTCA GCAGCCCCGA TTCAGCTOCA GCTCCACAGC ACCCCTOCCC TCACCTCTCT CCTCTCCCCA CAGATGTCCC GCCTOGCCCT CCCGCTGGCG CCCCCCTCCT CAOCCTGOGGG GGGCATCAGG CTGACACTTG ACTOGGCCGT GAGOGGACTO CTGCTGCTGA ACCACCGTCC TTCCAAAGCC AGATCTATT TATTTATTTA ATCCCCCCGC CATTATCTCC CCCTAGTTAG AGACAGTCCT ATTTATACTT AT11'ATTTCA GOAGCAOGGG TGGGAGGCAG ACTGGOGTCC CGGATTCTTG GGTCTCCAAG AAOTCTGTCC AGGCCTGOOC AGGAACATAT ATTATTTAT7 TAAOCAATTA AAGOGAAOCC TGGGT=~fG TACAAAAATG TOAGAAACCT GTCATACATA TCCACTTGAG OOCGATTTGT CTGAGAGCTG AGCCCGTCCT GACTCCAOCC TCCATT-rTCG CCCCACGCGC CACAGTCCCC CTGTGAATAT TGCACCCCCO CTGCACCCCC TACCTGTGAC GCCCCAGCCA CCCCCGGACC CGCCGGCGCC GCCGCCCACG CCATCCTGGG GGGGCTGCAC AOACTCGGCT GTOACCCOOG GCCCAAAOCC TTTCAGTACT GGGGGCOAAA CAOCCAOOTG TCCGTGAOGC CTGGGOCA TCTGTGCCTT GTOOACTCCT GGGTCCCCGA OGAGGAGGOG ACAGAC~rCT GCCCTGGCTC TTCCCCATCT CT1TTCATOT TGGGGTGGGG ACOGAGGOGA TTGTGAGACA GAGAACAGGG AATTAAATGT GGGCTGOATO CTTGTAAC TGGGGCAGGG CAGGTGGAOG GGAGACCTCC GTCACCCAGA CAGCTCTOTG GTTTGTTM~ TGAGATGOAG OCAACCTCCA CCTCCCGOGT GCACCACCAT OCCCAGCTAA CCAGGCTGGT TTCGAACTCC GGTGTGAGCC ACCACACCTG GTGATCAACA OTACCCGTAT GCAAACTGGA AACAATCTAG CACCCAGCCG CCCGGAGCAG AGATATCCTG ACATTGGCCA GTGGATCACT OAAGTCCAAG AGAATGATOT CCTGACATOA

ATTCAGGTGG

GAOOCAGOGT

TCTCGCTCTO

TCAAGCAATT

TTATT[ATTT

TGACCTCAGG

ACCCATAGGT

GGGACAAAGC

ATATCCAACA

GGACTGTCAT

GGCATOTOGG

AGTTTGAGAC

AGGTCCCOAG

CTGAGCCTTG

TTGCCTAGGC

CTCCTGCCTC

C~rTTGTATr

TGATCCTCCT

CYJTCAATAAA

TGCAAGGTCA

GTGAGGG3TA

TCAGGGAGGC

CTCACGCCTG

CGGCCTGCGA

TGGGCGGGGC

CCTGGGGCCC

TGGAGTGCAG

AGCCTCCCGA

TTTAGTAGAG

GCCTCGGCCT

TATTTAATG

AGATGGTTCA

AGCAACATOO

TAAGGAGAGA

AGCGACTGGG

CGCACTGCAT

TGAGOCAATC

T[AGCTGGGA

ACAGGGTTTC

CCCAAAGTGC

AAOGTTCCAC

.TTATGGCTGT

TGCATCTGTO

GGCTTGCTTG

AGATGGGTCG

AGGGCCGTTF

TAAGGTCACT

TCACAGGTGT

ACCATGTTOO

TGGGATTACA

AAGTCACCCT

GTTCACCATA

GATAGAACGC

GGATATAGAA

TAATCCTGOC ACTTTGGGAG GACGAAGCGA GACATGGCAA AACCCTGTCT CAAAAAAOAA AACAGCAGGC TACAAAACCA CTGCATOCTG TGATCCCAAT TTTOTGTTTT TCTTTCTATA TATGGATTAA AACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTrGACAA TGACTGTCTC CAGGTCAAAG GAGAGAGGTG GGATTOTGGG TOACTTTTAA TGTGTATGAT TGTCTGTAT[ TTACAGAATT TCTOCCATGA CTGTOTATrT TGCATGACAC AT1TTAAAAA TAATAAACAC TATTfTTTAGA ATAACAGAAT ATCAGCCTCC TCCTCTCCAA AAATAAGCCC TCAGGAGGGG ACAAAGTTGA CCGCTGATTG AGCCTGTCAO GOCTGTGCAC-3' (FRAG. (SEQ. ID KO:2522) Human GM-CSF Nucleic Acid and Antisense Oli~onucleotide Fragments 5'-CTT7GBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTOG CTTCCTGCBC TGTCCBOBGT GCBCTOTOCC BCBGCBGCBG CTGCBGGGCC BTCBGCfTCB TGGGGCTCTG GGTOOCBGGT CCBGCCBTGG GTCTGGOTGO GGCTGGGCTO CBGGCTCCGG GCGGTCCBGCCBTGGGTCTO GGOCTGO CTGCBGOCTC CGGGCGGGCG GGTGCGGGCT GCGTGCTGGG GGCTGCCCCG CAGGCCCTGC GGTCCBGCCB TGTCTGGG GGCTGGGCTG CBGGCTCCGG GCGGGCGGGT GCGGGCTGCG TGCTGGGGGC TGCCCCGCAG GCCCTGC-3' (FRAG. NO:1847) (SEQ. ID NO: 1860) BBG-3' (FRAG. NO:1848) (SEQ. ID NO: 1861) 5'-GCCBCBGCBOCBGC-3' (FRAG. NO:1849) (SEQ. ID NO: 1862) 5'-000 TGC GGG C-3' (FRAG. NO:1850) (SEQ. ID NO: 1863) CCB 0CC BTG GGT CTG GG-3D (FRAG. NO:1300)(SEQ. ID NO:1309) TGG OCT GCB OGC TCC GO-3D (FRAG. NO:1301)(SEQ. ID NO:1310) TGC GGGCTG CGT GCT GGG-3ii (FRAG. NO:1302)(SEQ. ID NO:1311) 5D-GGC TOC CCC GCA GOC CCT GC-3U (FRAG. NO:1303)(SEQ. ID NO:1312) BBGCTCTGGG GCBGOGBGCT GGCBGGGCCC BGGGOTGG CTTCCTGCBC TGTCCBGBGT GCBCTGTOCC BCBGCBGCBG CTGCBGGGCC BTCBGCTI'CB TGGGGCTCTG GGTGGCBGGT CCBGCCBTGG GTCTGGGTGG GGCTGOOCTG CBGGCTCCGO OC-3' (FRAG. NO:1851) (SEQ. ID NO: 1864) Human Tumor Necrosis Factor X( Antisense Oligonucleotide Fragments 5'-GCBCCOCCTG GBGCCCTGGG GCCCCCCTGT CYJ7CTTGGGG BGCGCCTCCT

BTCBTGCT

TOCTCBTOGT

CTCTCCCTCT

TGGTIITTCTC

TOTCCTCTCT

COTOTCTCCB

CTCBTOOTOT

TCTCCCTCTC

GGTITFCTCT

OTCCTCTCTO

CBGTGCTCBT

GTCCTT-rCCG CT-rGCGTCTC

TCTCCGCTGG

OTCTOTCOCC

OTGCTCBTGG

CC1TTCCGCC

TTGCGTCTCT

CTCCGCTGGC

TCTGTCGCCC

GGTGTCC1T[ CCBGGBOB CCCTGGGGCC CCCCTGTCTT TCTCTTTCTC TCTCTCTC1T CTOCCTOTCT OOCCTGCGCT CCCTCTOOOO TCTCCCTCTO

GBGGGCTG

CTTGGOOCCT

CCCCTJ7CCC

CTTGGCCTGT

GGTGGTGGTC

CGGCCBGCTC

TCCTCTGCTG

CTJ7CCCTCTG

GCTCTITTCTG

GCTGTTCCTC

TTGTTOCrTO

CBCGTCCCGG

TCCTTGCTGG

GGOGCCGTCT

TCTCOOTOTC

CTCCOOTrCC

GGCTGGGCTC

TGTCCGCTGB GGGBGCOTCT OCTOOCOCTO GTCCTCTOCTGTC CTFrGCTOOTO CTOOGGCCCC CCTOTCTTCT TGGOOCCTCT TCCCTCTOOO OGCCOTCTC CTCTTTCTCT CTCTCTCTTC CCCYI1CCCG CTCTTTCTGT CTCOOTOTCT TGCCTOTCTO OCCTCOCCTC TTOGCCTOTO CTOTTCCTCC TCCGOTTCCT CCTCTOOOOT CTCCCTCTOO COTOOTOOTC TTGTTGCr OOCTOOOCTC CGTGTCTCCB OTOCTCBTOO TOTCCGCTOB OOOBOCOTCT GCTGGC-31 (FRAG.NO:1852)(SEQ.ID NO:1865) 5'-OOOOCCCCCC-3' (FRAG. NO:1853) (SEQ. ID NO:1866) 000 OOC CO TCT-3' (FRAG. NO:1854) (SEQ. ID NO:1867) OBOOOGCTOO-3' (FRAG. NO:1855) (SEQ. ID NO:1868) 254 GBGCCCTGGG GCCCCCCTOT CT-FTUGGGG BGCOCCTCCT CGGCCBGCTC CBCGTCCCGG BTCBTGCT-TT CBGTOCTCBT GGTGTCCTTT CCBGGGGBGB GBGGG-31 (FRAC. NO:1304) (SEQ. ID NO:1313) GOT CCT CTG CTO TCC U-G CTG OTO CTC BTO GTG TCC MT CC GCC CTG GOG CCC CCC TOT CUT CU- GOG G CCT CUT CCC TCT GGG GGC CO TCT CTC TCC CTC TCT TGC OTC TCT C TCT UTC TCT CTC TCT CUT CCC C Tf CCC GCT CUT TCT GTC TC GGT OTC TGG TUT TCT CTC TCC GCT OGC TGC CTG TCT GOC CTG COC TCT T GGC CTO TG TGT TCC TCC TCC GGT TCC TOT CCT CTC TGT CTG TC GCC CCC TCT GGG GTC TCC CTC TG C OTG GTG GTCTUGTUG CTT GGG CTG GGC TCC GTG TCT CCBO TGC TCB TGO TOTCC-3' (FRAG. NO:1305) (SEQ. ID NO:1314) GBG 0GB GCG TCT OCT GGC GCT GGT CCT CTG CTG TCC U-G CTG GTG CTC BTG OTO TCC lT CC 0CC CTG 000 CCC CCC TOT CUT CTT 0000G CCT CUT CCC TCT 000 OOC CO TCT CTC TCC CTC TCT TOC OTC TCT C TCT UTC TCT CTC TCT CUT CCC C UTT CCC OCT CUT TCT OTC TC OOT OTC TOO UT TCT CTC TCC OCT GOC TOC CTO TCT GOC CTO COC TCT T GOC CTO TOC TOT TCC TCC TCC GOT TCC TOT CCT CTC TOT CTO TC 0CC CCC TCT 000 OTC TCC CTC TOG C OTO OTO OTC TTO U-G CUT 000 CTG GOC TCC OTO TCT C CBO TOC TCB TOG TOT CC OCT OBO GOB OCO TCT OCT OOC-3(FRAG.NO:1306)(SEQ.ID NO: 1315) 51D-OCT GOT CCT CTO CTO TCC U-G CTG-315 (FRAG. NO:165S) (SEQ. ID NO:1664) 51i-GTG CTC BTO OTO TCC rrr CC-30 (FRAG. NO:1656)(SEQ. ID NO:1665) CTG 000 CCC CCC TOT CUT CU 000 G-30 (FRAG. NO:1657)(SEQ. ID NO:1666) 51i-CCT CUT CCC TCT 000 GOC CO-3U (FRAG. NO:1658)(SEQ. ID NO:1667) CTC TCC CTC TCT TOC OTC TCT C-3D (FRAG. NO:1659)(SEQ. ID NO:1668) 2 0 5D-TCT U-C TCT CTC TCT CUT CCC C-3Dl (FRAG. NO:1660)(SEQ. ID NO:1669) CCC OCT CUF TCT OTC TC-31i (FRAG. NO:1661)(SEQ. ID NO:1670) OTC TOO UTT TCT CTC TCC-30 (FRAG. NO:1662)(SEQ. ID NO:1671) SD-OCT OOC TOC CTO TCT OOC CTO COC TCT T-30 (FRAG. NO:1663)(SEQ. ID NO:1672) 51]-GGCCTG TGCTOT TCCTICC-3D] (FRAG. NO:1664)(SEQ. ID NO:1673) 5D-TCCGTTCC TOTCCT CTC TOTCTG TC-31i (FRAG. NO:1665)(SEQ. ID NO:1674) CCC TCTGGGTCTICCCTCTOOGC-3Di (FRAG. NO:I666)(SEQ. ID NO:1675) 51]-GTGGTGGTCTUGTUTGCUT-3Di (FRAG. NO:I667)(SEQ. ID NO:1676) 5D-000 CTO OC TCC OTOTCT C-3D (FRAG. NO:I668)(SEQ. ID NO:1677) TOC TCB TOO TOTCC-3' (FRAG. NO:1669)(SEQ. ID NO:1678) SD]-OCTGOBGGGOBGCGTCTGOCTGGOC-3ii (FRAG. NO:1670)(SEQ. ID NO:1679) Human Leukotriene C4 Synthase Nucleic Acids and Antisense Oli2onucleotide Fra2ments GCOCTCOBBC TCOOOTOOGC COOTOOTOHO CGGCOGCGBCB COCOOBBOOC CCTGCGCOCC OBOBTCBCCTO CBGOOBOBBG TBGOCUOGCB OCBGOBCTCC CBOOBOOOTO BCBOCBOCCB GTBGBOCTBC CTCOTCCU-C BTOOTBCCGT COOTOTOOTO GCBCOOGCTO TOTOTOBBOO COBOCTOOOC CCCOTCTOCT OCTCCTCOTO CCOCCTCOTC CU7CA TOO TA CCOTCGOTOT OOTGGCCTCG GGTOOOCCOG TOOTOGGOCO CGCOCOCTCO COTOOCTCCO OCTCTTCUTT CCCOOCTCCOT COGCCCGOOG OCCTTOOTCT CCCTCOTCCT TCBTOGTBCC 0-3- (FRAG. NO:1856) (SEQ ID NO: 1869) GCBOOBC-3' (FRAG. NO:1857) (SEQ ID NO: 1870) 5'-CCCOOCTCCG-3' (FRAG. NO:1858) (SEQ ID NO: 1871) S'-COOCCCOOOO OCC-3' (FRAG. NO:1859) (SEQ ID NO:1872) COCOO-3- (FRAG. NO:1860) (SEQ ID NO: 1873) 51D-GCC CCGTCTGOCTGOCTCCTCOTG0CCG0-3D (FRAG. NO:1307)(SEQ. ID NO:1316) COT CCI ICA TOG TAC COT COO TOT GOT OOC-30 (FRAG. NO:1308)(SEQ. ID NO:1317) 51i-CTC 000 TOO 0CC OOT GOT 0-3D (FRAG. NO:1309)(SEQ. ID NO:1318) COC OCO COC TCO COT-3D (FRAG. NO:1310)(SEQ. ID NO:1319) TCC GOC TCT ICT TTC CCO OCT CCO TCG 0CC COO 000G CCT TOO TCT C-3D(viiAc.NO:31)(SEQ.ID NO:1320) S'-CCT COT CCT TCB TOG TBC CO-3DJ (FRAG. NO:1312)(SEQ. ID NO:1321) 5S-CTCOOTBGBC OCGCTCGBBC TCOOOTGOC COOTOOTOBO CGGCGGCGBCB COCOOBBOOC CCTOCOCOCC OBGBTCBCCTG CBOOOBGBBO TBOOCUOGCB OCBOGBCTCC CBGOBOOOTO BCBOCBGCCB GTBOBGCTBC CTCOTCCTTC BTOOTBCCOT COOTOTOOTO GCBCOOGCTG TGTOTOBBOO COBOCTOO-3' (FRAG.NO: 1861) (SEQ ID NO: 1874) Human Endothelin-1 Nucleic Acids and Antisense Oligonucleotide Fragments 5'-BCCOGCOOBO CCGCCBOOGT OOBCTOOGBO TOGGTITfCTC CCCGCCGUTC TCBCCCBCCO CGCTGBOCTC BOCOCCTBBO BCTOCTGUTT CTGOBOCTCC UOOGCBBOCC BCBBBCBGCB OBOBOBBBBT CBTGBOCBBB TBBTCCBTI7C TOBBBBBBBO OGBTCBBBBB CCICCCOUTC CCCGUTCOCC TOOCOCOCOC TGCGOTTCC TCOTOOOT CTCCCCGCCG UTCTCCOGTC TGUTGCCTIT OTGOCUTCT TGTCTTTJ7 OCTGUTCTTT TCCTOCTTGO CGTCTITITCC MTITTGTG CTCOGTTOTO GGTCCGCTGG TCCT1TOCCC TOTGTOTC TOCTOCCCOT TCOCCTOOCO COCOCTGCOO OUrCCTCOIO OOTTCTCCC COCCOTTCTC CGOTCTOUOG CCTTGOG CUTCTTGICT TffOCTOT TCTITTCCTO CU-GOCOICT UTTCCUrTCT UTOTCTCGO UTOOOGGTCC GCTOOTCCU TGCCCTOTOT OTTJTCICTO-3' (FRAG. NO:1862) (SEQ. ID NO:1875) CCOCCBOOOT OOBC-3- (FRAG. NO:1863) (SEQ. ID NO:1876) 5S-CCGCCBOGO-3' (FRAG. NO:1864) (SEQ. ID NO:1877) 5'-GOCOCOCOC-3' (FRAG. NO:1865) (SEQ. ID NO:1878) 255 5'-GTGGGTCCGC-3- (FRAG. NO:1866) (SEQ. ID NO:1879) 5'-CCCGTTCGCCTGGCGC-3' (FRAG. NO:1313)(SEQ. ID NO:1322) 5'-GCGCTGCGGGT-rCCTC-3' (FRAG. NO:1314)(SEQ. ID NO:1323) 5'-GTGGGTTrCTCCCCGCCGTTCTC-3' (FRAG. NO:131 5)(SEQ. ID NO:1 324) 5'-CGGTCTGTTGCCTTTGTGGG (FRAG. NO:1316)(SEQ. ID NO:1325) 5'-CTrCTTGTCTTTTTGGCT-3' (FRAG. NO:1317)(SEQ. ID NO:1326) 5'-GTTCTTTTCCTGCT-rGGC-3' (FRAG. NO:1318)(SEQ. ID NO:1327) 5'-GTCTTFTTCCTTTCTT-3' (FRAG. NO:1319)(SEQ. ID NO:1328) 5'-TGTGCTCGGTTGTGGGTC-3' (FRAG. NO:1320)(SEQ. ID NO:1329) 5'-CGCTGGTCCTTTGCC-3' (FRAG. NO:1321)(SEQ. ID NO:1330) 5'-CTGTGTGTTTCTGCTG-3' (FRAG. NO:1322)(SEQ. ID NO:I331) 5'-CCCGTTCGCCTGGCGC-3' (FRAG. NO:1323)(SEQ. ID NO:1332) 5'-GCGCTGCGGGTTCCTC-3' (FRAG. NO:1324)(SEQ. ID NO:1333) 5'-GTGGGTTTCTCCCCGCCGTTCTC-3' (FRAG. NO:1325(SEQ. ID NO:1334) 5'-CGGTCTGTTGCCTTTGTGGG-3' (FRAG. NO:1326)(SEQ. ID NO:1335) 5'-CT[CTTGTCTTTTTGGCT-3' (FRAG. NO:1327)(SEQ. ID NO:1336) 5'-GTI7CTTTTCCTGCT-rGGC-3' (FRAG. NO:1328)(SEQ. ID NO:1337) 5'-GTC-rTTTCCTTTC'rr-3' (FRAG. NO:1329)(SEQ. ID NO:1338) 5'-TGTGCTCGGTTGTGGGTC-3* (FRAG. NO:1330)(SEQ. ID NO:1339) 5'-CGCTGGTCCTTTGCC-3' (FRAG. NO:133I)(SEQ. ID NO:I340) 5'-CTGTGTGTTTCTGCTG-3' (FRAG. NO:I332)(SEQ. ID NO:1341) Endothelin Receptor FT-B Nucleic Acids and Antisense Oligonucleotide Frag~ments GCGGGAAGCC TCTCTCCTCT CCCCAGATC CGCGACAGGC CGCAGGCAAG AACCAGCGCA ACCAGGGCGC GTCCGCACAG ACTI7GGAGGC GGCTGCATGC TGCTACCTGC TCCAGAAGCG TCCGGTGGCC GCCGCGCC CTGTCGGGCG GGBBGCCTCT CTCCTCTCCC CBGBTCCGCG BCBGGCCGCB GGCBBGBBCC BGCGCBBCCB GGGCGCGTCC GCBCBGBC'rr GGBGGCGGCT GCBTGCTGCT BCCTGCTCGGGCG GGBBGCCTCCG GTGGCCGCCG CGCGTCCGGT GGCCGCCGCG CCTCTCTCCT CTCCCCGTGG CCCTGTCGGG CGGGTCCTGC CGTrCCTGTCT CCTTfCTTT TGCTGTCTTG TCT-rCCCGTC TCTGCTTT-3- (FRAG. NO: 1867) (SEQ. ID NO: 1880) 5'-CGGGCG GGBBGCC-3' (FRAG. NO: 1868) (SEQ. ID NO: 1881) 5'-CGGGCGGG-3- (FRAG. NO: 1869) (SEQ. ID NO: 1882) 5'-CCGCBCBGBC-3' (FRAG. NO: 1870) (SEQ. ID NO: 1883) 5'-GCGTCCGGTGGCCGCCGC-3- (FRAG. NO:1333)(SEQ. ID NO: 1342) 5'-GCCTCTCTCCTCTCCCC-3' (FRAG. NO:1334)(SEQ. ID NO:1343) 5'-GTGGCCCTGTCGGGCGGG-3' (FRAG. NO:1335)(SEQ. ID NO:1344) 5'-TCCTGCCGTCCTGTCTCCITF1-3' (FRAG. NO:1336)(SEQ. ID NO:1345) 5'-TCT1'TTGCTGTCTTGT-3' (FRAG. NO:1337)(SEQ. ID NO:1346) 5'-CITCCCGTCTCTGCITT-3' (FRAG. NO:1338)(SEQ. ID NO:1347) GCGGGAAGCC TCTCTCCTCT CCCCAGATC CGCGACAGGC CGCAGGCAAG AACCAGCGCA ACCAGGGCGC GTCCGCACAG ACYITGGAGGC GGCTGCATGC TGCTACCTGC TCCAGAAGCG TCCGGTGGCC GCCGC-3' (FRAG. NO: 1871) (SEQ. ID NO: 1884) GCGGGBBGCC TCTCTCCTCT CCCCBGBTCC GCGBCBGGCC GCBGGCBBGB BCCBGCGCB BCCBGGGCGC GTCCGCBCBG BCTfGGBGGC GGCTGCBTGC TGCTBCCTGC TCCBGBBGCG TCCGGTGGCC GCCGC-3' (FRAG. NO: 1872) (SEQ. ID NO: 1885) Endothelin ETA Receptor Nucleic Acids and Antisense Oligonucleotide Fragments CCCGTCTCCT CCCACTGCT[ CTCCCGGGGG CTTCCCCGGC YrCGGGTGGC CGGTGTCCCG GGCTCCGGCG CGGCGGCGGC -FCGGCTGCG GGTGGGTGGC GCGGGCTGCC GGGTCCGCGC GGCGCCTGGG CCCTITGTGCT GCTTTrTGCT TGTTCCGTTC TGGCTGCTCC GGTCTGTGTTr GTGGTTGTTT TGT117CTITCT TGGGTGTGGG ccT-rGCGGTT TTGGCTGTGG GCCCTITGGG GCCTTGGCTT CTGGCTCGTC TGTCCTCCCC GTCTCCTCCC ACTGCTrCT CCCGGGGGCT TCCCCGGCTT CGGGTGGCCG GTGTCCCGGG CTCCGGCGCG GCGGCGGCTT CGGCTGCGGG TGGGTGGCGC GGGCTGCCGG GTCCGCGCGG CGCCTGGGCC C'TGTGCTGC TTTTGCTTG TTCCGTTCTG GCTGCTCCGG TCTGTGTTGT GGTTGTTTrTG TTTCTTCYI7G GGTGTGGGCC TTGCGGTTTT7 GGCTGTGGGC CCTTTGGGGC CTrGGCTTCT GGCTCCAT CCACATGATT GCTTAGATT GTGCTGTATC TCTCAGGATT ATCACTGATT ACACATCCAA CCAGTGCCAG CCAAAAGGAT GCCCTGAGGC AAAGGGTTTC CATCT-rGAGG CAAATTTGAG GACBTCCBC BTGBTTGCTT BGB1TFGTGC TGTBTCTCTC BGGBTTBTCB CTGBTTBCBC BTCCBBCCBG TGCCBGCCBB BBGGBTGCCC TGBGGCBBBG GGT-rTCCBTC TTGBGGCBBB TrGBGGB-3' (FRAG. NO:1873) (SEQ. ID NO: 1886) 5'-GBGGCBBBGGG-3' (FRAG. NO: 1874) (SEQ. ID NO: 1887 5'-GCCBGCCBB BBGGB-3' (FRAG. NO:1875) (SEQ. ID NO: 1888) C-3- (FRAG. NO:1876) (SEQ. ID NO: 1889) 5'-GTCTGTCCTCCCCGTCTCCTCCC-3- (FRAG. NO:1339)(SEQ. ID NO:1348) 5'-ACTGCTTCTCCCGGGG-3' (FRAG. NO:1340)(SEQ. ID NO:1349) 5'-GCTTCCCCGGCTTC-3- (FRAG. NO:1341)(SEQ. ID NO:1350) 256 5'-GGGTGGCCGGTGTCCCGGGCTCCGGCGCGGCGGC-3- (FRAG. NO:1342)(SEQ. ID NO:1351) 5'-GGCTTCGGCTGC-3' (FRAG. NO:1343)(SEQ. ID NO:1352) 5'-GGGTGGGTGGCGCGG-3' (FRAG. NO:1344)(SEQ. ID NO:1353) 5'-GCTGCCGGGTCCGCGCGGCGGCTGGGCC-3' (FRAG. NO:1345)(SEQ. ID NO:1354) 5'-CTTGTGCTGCTT-r--3' (FRAG. NO:1346(SEQ. ID NO:1355) 5'-TGCTTGTTCCGTTC-3' (FRAG. NO:1347)(SEQ. ID NO:1356) 5'-TGGCTGCTCCGGTCTGTGYITGTGGTTGTTITG-3' (FRAG. NO:1348)(SEQ. ID NO:1 357) 5'-TTTCTTCTTGGGTGTGGG-3' (FRAG. NO:1349)(SEQ. ID NO:I358) 5'-CCT[GCGGMhJTGG-3' (FRAG. NO:1350)(SEQ. ID NO:1359) 5'-CTGTGGGCCCTfTG-3' (FRAG. NO:1351)(SEQ. ID NO:1360) 5'-GGGCCTTGGCTTCTGGCTC-3' (FRAG. NO:1352)(SEQ. ID NO:1361) ATTGCTTAGA TTTGTGCTGT ATCTCTCAGG AT[ATCACTG ATTACACATC CAACCAGTGC CAGCCAAAAG GATGCCCTGA GGCAAAGGGT TTCCATCTTG AGGCAAATTFI GAGGA-3' (FRAG.NO:1353) (SEQ.ID NO:1362) 5'-CBTCCBCBTG BTITGC1TBGB YTTGTGCTGT BTCTCTCBGG BTrBTCBCTG BUTBCBCBTC CBBCCBGTGC CBGCCBBBBG GBTGCCCTGB GGCBBBGGGT TTCCBTCYTG BGGCBBBT-17 GBGGB-3' (FRAG. NO:1354)(SEQ. tD NO:1363) Endothelin Receptor A Nucleic Acid and Antisense Oligonucleotide Fragments AAACCCTTTG CCTCAGGGCA TCCTT-rTGGC TGGCACTGGT

ATCCTGAGAG

CAGCTTCCTG

TGCCCACAGC

TCGTGGGAAT

CAACGCGCTG

TGGCTGGGCG

GAAGTCCTCG

TCCTGGAGTC

ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC GTTACCACTC ATCAACCCAC TAATTTGGTC CTACCCAGCA

AGACTAAAAT

GGTGGGGAAT

ATAGCCAGTC

CTGGCCTTTT

GTGGGGATCA

GTGTTCAGGG

TACTTCAGCT TTCAAATACA YI7AACACTGT TGGATGTGTA ATCAGTGATA ACTTrrCGTG GCACAGAGCT ATGGCTCAAT GCACAACTAT GATATCTTGT ACTATTrTCA AAATGTATGA GGAATGGCCC TTGATCTCCC TATCAATGTA AAGCTGTTCC CCTTTTTGCA

GCAACTCTGC

TTFGCCCTTGG

GATCACAATG

CCGTCCTCAA

AATTGGGATT

CCTGAAGCGA

ATGCCACATC

TATGCCCTTG

AGCYJ7GAGAA

TTGTAATTTT

TCAGGATCAT

AGACCTTATC

ACTTTGGCGT

CCTCTGCGCT

CCTITTGGTAA

TTGGCTTCGT

AAAATTCATG

GTGTGCACTG

TTGCCCTCAG

TGCTCT'[TGC

TTACCAGAAC

TATGTGGTCA

ATFCTTTGC

TGTCCT-TAT CCTGGCCATT

GCATAAAACC

CTCTTCGGGT

TGTTGAACAG

AAAAACAGTT

AAGAAAACTG

ACATCGGTAT

ATTIAAAAAT

CCCATGAACG

ATAAGGACAG

AGCACAAGTG

TGTATGCTCA

TCTATTTCTG

AAGGAATGGC

TTCTGCT-FGG

TGTATAACGA

TAACTrFGGCA

TGTTTCCAGT

GAACAAGCAT

CATGAACTGA

CAATAAGAGA

CTTAGTGTTG ACAGGTACAG CTGCCATTrGA AATTGCCTCC CATGGTACCC TTTGAATATA GAGTTCTACC AAGATGTAAA CGATCTTCTA CACCCTCATG TGAACATCT[ AAGCAGCGTC TGGTTCCCTC T-rCATTTAAG

AGCAGTTGCC

ATCTGGATCC

GGGGTGGACA

GGACTGGTGG

ACTGGTGAGA

GAGAAGTGGC

CCGTATATTG

GATGGACAAG AACCGATGTG AATTACTTAG TTJ7CTTACTG CTCATGGATT TTTTGGCTGG CACTGGTTGG ATGTGGATGA TTFTCACCACT T-TTGGTCCTA CCCAGCAATG ACCATGAATT CATGTATAAA CATGCCTCTG CTGCTGCTGT CCAGTGGAAG AACCACGATC CCACCCU7AG AAGCACTCCT TATTTCCTCA AATTTGCCTC ATGTGTAATC AGTGATAATC TTTCGTGGCA CAGAGCTCAG GCTCAATGCA CAACTATTGC ATCTTGTACT ATT'rrCATCG TGTATGAGGA ATGGCCCCAA ATCTCCTAT CAATGTATTT TCTTTGCAAG CTGTTCCCCT AGTGTTGACA GGTACAGAGC CCATJ7GAAAT TGTCTCCATC GGTACCCYIT GAATATAGGG CCCCATAGCT CTGTATTITTG TGAGCAAGAA TACCAGTCCA AAAGTCTGAT GACCTCGGTC AAAACAACCA CAACACAGAC CGGAGCAGCC GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AAGATGGAAA CCCTTTGCCT CAGGGCATCC CTGAGAGATA CAGCACAAAT CTAAGCAATC CTTCCTGGTT ACCACTCATC AACCCACTAA CCACAGCAGA CTAAAATTAC TTCAGCTT-UC TGGGAATGGT GGGGAATGCA ACTCTGCTCA CGCGCTGATA GCCAGTC'rfG CCC1TGGAGA AAGCTGCTGG CTGGGCGCTG GCCTTTTrGAT Y[TTGCAGAA GTCCTCGGTG GGGATCACCG AG1TGCCTCC TGGAGTCGTG TTCAGGGAAT TGGATCCTGT CCTTFATCCT GGCCATCT GTGAACAGCA TAAAACCTGT ATGCTCAATG

AAATACATTA

GGATCATT7A

CCTUATCTAT

CACAATGACT

TCCTCAACCT

TGGGATTCCT

GAAGCGATTG

CCACATCAAA

GCCCT-FGGTG

YI7GAGAATTG TAATrTGC

ACACTGTGAT

CCAGAACAAA

GTGGTCATTG

TTGGCGTAYI7

CTGCGCTCTT

TTGGTAACTG

GCTTCGTCAT

ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC YI'CGGGTTCT ATTTCTGTAT TGCACTGCGA TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC CCCTCAGTGA ACATC'r7AAG CAGCGTCGAG AAGTGGCAAA AACAGTT-TC TGCTTGGTTG TCTTTGCTGG TTCCCTCTfC A1TTAAGCCG TATATTGAAG GGACAAGAAC CGATGTGAAT TACTTAG'TT CTTACTGCTC ATGGATTACA ATGAATTCAT GTATAAACCC CATAGCTCTG TATfGTGA GCAAGAAATT GCCTCTGCTG CTGCTGTTrAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA CCCTTrAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT GGGAATCTCT TCTCTGATCC FUCTTCCTITA AT7CACTCCC ACACCCAAGA AAAACTGTGT ATAACGAGAT TCGGTATTAA CYUGGCAACC TAAAAATUGT TTCCAGTCAT ATGAACGGAA CAAGCATCCA AGGACAGCAT GAACTGACCA CACAAGGCAA CTGTGAGTCC AGAAATGCT- TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AAT1TTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTr TGCATGAAAA TAGAGCTrTC AAGTACATGG CTAGCTrTrA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGATTrTrC TACTITTrTTT AAGTGATITT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTfGAAA TGTCATTTGG TGCCAGTATC CCGAATTC GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TA'ITCCTCA AA17rGCCTC AAGATGGAAA CCCTTGCCT CAGGGCATCC TT'TGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTrCACCACT 1TTTCGTGGCA CAGAGCTCAG C117CCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG 257 GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCT[TC ATCTTGTACT ATFT1CATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTITGAT TCTTTGCAAG CTGTTCCCCT TTTGCAGAA GTCCTCGGTG GGGATCACCG AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG T1TCAGGGAAT CCATTGAAAT TGTCTCCATC TGGATCCTGT CCYFTATCCT GGCCATTCCT GGTACCCUT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC T-rCGGGTTCT AMTCTGTAT TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC AAATACAUTA ACACTGTGAT GGATCATTTA CCAGAACAAA CCTTATCTAT GTGGTCATTG CACAATGACT TTGGCGTATT TCCTCAACCT CTGCGCTCTT TGGGATITCCT TTGGTAACTG GAAGCGATTG GCTTCGTCAT CCACATCAAA ATTCATGGAG GCCCTI7GGTG TGCACTGCGA TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTY[FTC TGCTTGGTTG TAArTTrTTGC TCTTTGCTGG -FlCCCTCTTC ATTTAAGCCG TATA11TGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTI7 CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAA11TCAT GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGUTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTrAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC 'ITCTJTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTFCTT TAATTGATCT AA1TfACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTrf CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGATTYFC TAC'ITTTrT AAGTGATTrT Y[rTGTCCYTC AGCCAAACAC AATATGGGCT CAAGTCACTT TTAYFI7GAAA TGTCATTTGG TGCCAGTATC CCGAATTC-31 (FRAG. (SEQ ID NO: 3014) 5'-GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTTGCCTC

AAGATGGAAA

CTGAGAGATA

CTTCCTGGTT

CCACAGCAGA

TGGGAATGOT

CGCGCTGATA

AAGCTGCTGG

TT[TGCAGAA

AGTTGCCTCC

TGGATCCTGT

GTGAACAGCA

CTGGTGGCTC

TGTGAGATGT

AAGTGGCAAA

TATATTGAAG

ATGGATTACA

GCAAGAAATT

CTCGGTCCCC

AGCAGCCATA

AGAAAAAAAT

ACACCCAAGA

CGTAC'rrCTT

GGGGGAGAAT

AAGTACATGG

AGATTAACGA

CCC'TrTGCCT CAGGGCATCC CAGCACAAAT CTAAGCAATC

ACCACTCATC

CTAAAATTAC

GGGGAATGCA

GCCAGTCTI7G CTGGGCGCTrG

GTCCTCGGTG

TGGAGTCGTG

CCTTI'ATCCT

TAAAACCTGT

TTCGGGTTCT

TGAACAGAAG

AACAGTTTTC

AAAACTGTGT

TCGGTATTAA

TAAAAATTGT

AACCCACTAA

TTCAGCTTfC

ACTCTGCTCA

CCCTTGGAGA

GCCT1TI7GAT

GGGATCACCG

TTCAGGGAAT

GGCCATYFCCT

ATGCTCAATG

ATTTCTGTAT

GAATGGCAGC

TGCTTGGYJTG

ATAACGAGAT

CTrGGCAACC YI7CCAGTCAT TT1TTGGCTGG CACTGGTrGG ATGTGGATGA TTI'CACCACT TTTGGTCCTA CCCAGCAATG AAATACATTA ACACTGTGAT GGATCATTTA CCAGAACAAA

ATGTGTAATC

TYTTCGTGGCA

GCTCAATGCA

ATCTI'GTACT

TGTATGAGGA

ATCTCCCTAT

TCTTTGCAAG

AGTGATAATC

CAGAGCTCAG

CAACTATTGC

AT1TTCATCG

ATGGCCCCAA

CAATGTATTT

CTGTTCCCCT

CCTTATCTAT

CACAATGACT

TCCTCAACCT

TGGGATTCCT

GAAGCGATTG

CCACATCAAA

GCCCTI7GGTG

TITGAGAATTG

TAATTYTGC

GGACAAGAAC

ATGAATTCAT

GCCTCTGCTG

GTGGTCATrG

TTGGCGTATT

CTGCGCTCTT AGTGTTGACA GGTACAGAGC TTGGTAACTG CCATTGAAAT TGTCTCCATC GCITCGTCAT GGTACCCTTr GAATATAGGG ATTCATGGAG TTCTACCAAG ATGTAAAGGA TGCACTGCGA TCTTCTACAC CCTCATGACT CCCTCAGTGA ACATCTTAAG CAGCGTCGAG TCTTTGCTGG TTCCCTCYFC AT17TAAGCCG

CGATGTGAA]

GTATAAACCC

CTGCTGTTAC

FTACTTAGTTT

CATAGCTCTG

CAGTCCAAAA

ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA AGGACAGCAT GAACTGACCA CCCTFTAGAAG CACTCCTCGG TACTCCCATA CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTTCCTTA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC TAATTGATCT AATTTACATA TTCTGCGTGT TGTATITCAGC ACTAAAAAAT GAAGACTGT[ AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA CTAGCTTT-rA TGGCAGTTFCT GGTGAATGTT CAATGGGAAC TGGTCACCAT CAAGATTTTC TACTTT[ AAGTGATTI1T TTTGTCCTrC AGCCAAACAC

CTTACTGCTC

TAT1T[GTGA

GTCTGATGAC

CACAGACCGG

ATCCTCTCGG

ATTCACTCCC

ATCTACGAAT

GGTGGGAGCT

TAGAGCTTTC

GAAACTTTAG

AATATGGGCT

CAAGTCACTT T7ATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC-3' (FRAG. (SEQ ID NO: 2482) AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTITCCTCA AATTTGCCTC AAGATGGAAA CCCTTrGCCT CTGAGAGATA CAGCACAAAT cTrcCTGGTT ACCACTCATC CCACAGCAGA CTAAAATTAC TGGGAATGGT GGGGAATGCA CGCGCTGATA GCCAGTCTTG AAGCTGCTGG CTGGGCGCTG UTTTGCAGAA GTCCTCGGTG AGTTGCCTCC TGGAGTCGTG TGGATCCTGT CCTTrATCCT GTGAACAGCA TAAAACCTGT CTGGTGGCTC TTCGGGTTCT TGTGAGATGT TGAACAGAAG AAGTGGCAAA AACAGTTC

CAGGGCATCC

CTAAGCAATC

AACCCACTAA

TFCAGCTTTC

ACTCTGCTCA

CCCTrTGGAGA

GCCTTGAT

GGGATCACCG

TTCAGGGAAT

TTrTTGGCTGG CACTGGT1'GG ATGTGGATGA TTrCACCACT TrFTGGTCCTA CCCAGCAATG AAATACATrA ACACTGTGAT GGATCATTTA CCAGAACAAA

CCTTATCTAT

CACAATGACT

TCCTCAACCT

TGGGATTCCT

GGCCATTCCT GAAGCGAT[G ATGCTCAATG CCACATCAAA A1TTTCTGTAT GCCCT-rGGTG GAATGGCAGC TTGAGAAFFG TGCTTGGTTG TAATTT-rTGC GTGGTCATrG TTGGCGTATr CTGCGCTC7FT

TTGGTAACTG

GCT7CGTCAT AT17CATGGAG

TGCACTGCGA

CCCTCAGTGA

TCTTTGCTGG

ATGTGTAATC AGTGATAATC TITCGTGGCA CAGAGCTCAG GCTCAATGCA CAACTATTGC ATCITGTACT AT1TrCATCG TGTATGAGGA ATGGCCCCAA ATCTCCCTAT CAATGTATTT TCMTGCAAG CTGTrCCCCT AGTGTTGACA GGTACAGAGC CCATTGAAAT TGTCTCCATC GGTACCCMT GAATATAGGG 'rrCTACCAAG ATGTAAAGGA TCTTCTACAC CCTCATGACT ACATCTTAAG CAGCGTCGAG TTCCCTCTTC ATTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTU CTTACTGCTC 258 ATGGATTACA TCGGTATTAA CTrGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TA1TTJTGTGA GCAAGAAATT TAAAAATTGT Y[CCAGTGAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCOG AGCAGCCATA AGGACAGGAT GAACTGACCA CCCTrAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC YFCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTrATC CACCCACAAC ATCTACGAAT CGTACT[CTr TAATTGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCTT[TA TGGCAGYECT GGTGAATGTr CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGATTTTC TACTTIT AAGTGATTr TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC-3'(FRAG. (SEQ ID NO: 2470) '-GCCACCATGG AAACCCT-ITG CCTCAGGGCA TCC1T-TGGC TGGCACTGGT TGGATGTGTA ATCAGTGATA

ATCCTGAGAG

CAGCTTCCTG

TGCCCACAGC

TCGTGGGAAT

CAACGCGCTG

TGGCTGGGCG

GAAGTCCTCG

TCCTGGAGTC

TGTCC'TrTAT

GCATAAAACC

CTC'CGGGT

TGTTGAACAG

AAAAACAGTT

AAGAAAACTG

ACATCGGTAT

ATTTAAAAAT

ATACAGGACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTTTTCGTG GTTACCACTC ATCAACCCAC TAAUTTGGTC CTACCCAGCA ATGGCTCAAT AGACTAAAAT TACTTCAGCT TTCAAATACA TJ7AACACTGT GATATCTTGT

GCACAGAGCT

GCACAACTAT

ACTATTTTCA

GGTGGGGAAT GCAACTCTGC TCAGGATCAT ATAGCCAGTC TTFGCCCTTGG AGACCUTATC CTGGCCTT GATCACAATG ACTTTGGCGT GTGGGGATCA CCGTCCTCAA CCTCTGCGCT GTGTrCAGGG AATTGGGATT CCTTTGGTAA CCTGGCCATT CCTGAAGCGA TTGGCTTCGT TGTATGCTCA ATGCCACATC AAAATI7CATG TTACCAGAAC AAATGTATGA GGAATGGCCC TATGTGGTCA TTGATCTCCC TATCAATGTA A1TTTCMTGC

CTFTAGTGTTG

CTGCCATTGA

CATGGTACCC

GAGTTCTACC

CGATCTTCTA

TGAACATCF[

TGGTTCCCTC

AAGCTGTTCC

ACAGGTACAG

AATTGCCTCC

TTTGAATATA

AAGATGTAAA

CACCCTCATG

AAGCAGCGTC

TTCATTTAAG

TCTATTTCTG TATGCCCTTG GTGTGCACTG AAGGAATGGC AGCYJ7GAGAA TTGCCCTCAG TTCTGCTTGG TTGTAATTTU TGCTCTTTGC

CCTTTTGCA

AGCAGTTGCC

ATCTGGATCC

GGGGTGGACA

GGACTGGTGG

ACTGGTGAGA

GAGAAGTGGC

CCGTATATTG

CTCATGGATT

TGAGCAAGAA

GACCTCGGTC

TGTATAACGA GATGGACAAG AACCGATGTG AATTACTTAG TTTCTTACTG TAACTI7GGCA ACCATGAATT CATGTATAAA CCGCATAGCT CTGTATTTTG TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCT-FAG AAGCACTCCT-3' (FRAG. (SEQ ID NO: 2469) Substance P Antisense Nucleic Acids and Oligonucleotide Antisense Oligonucleotide Fragments TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG TTCCTCCUTG BTCTGGTCGCT GTCGTBCCBG TCGGBCCBGT BBTTCBGBTC BTCBTfGGCT CCTBTTTCTT CTGCBBBCBG CTGBGTGGBG BCBBGBBBBB BGBCTGCCBB GGCCBCGBGG BTTTTCBTGT TGGBT-rTTGC GBCGGBCBGT CCCGCGGGGT GCTGAGTITC TCTGGTTCCT CCGBGCGCBC GTGGTCGCTC CGCGTTTCTC TGGTTCCTCC GGTCCCGCGG GGTGCTGTCT GGTCGCTGTC GTGGCTTGGG TCTCCGGGCG GTTTCCTTCC T-FTTCCGC-3' (FRAG. NO:1877) (SEQ ID NO: 1890) GGGCGB-3- (FRAG. NO:1878) (SEQ ID NO: 1891) 5'-GGCCBCGBGG-3' (FRAG. N 0:1879) (SEQ ID NO: 1892) 5'-GGGTCTCCGGGCG-3' (FRAG. NO:1880) (SEQ ID NO: 1893) TCTCCGGGCG G-3' (FRAG. NO:1881) (SEQ ID NO:1894) 5'-CGTGGTCGCTCCGC-3' (FRAG. NO:1355)(SEQ. ID NO:1364) 5'-GTTTCTCTGGTTCCTCCG-3' (FRAG. NO:1356)(SEQ. ID NO:I365) 5'-GTCCCGCGGGGTGCTG-3' (FRAG. NO:1357)(SEQ. ID NO:1366) 5'-TCTGGTCGCTGTCGT-3' (FRAG. NO:1358)(SEQ. ID NO:1367) 5'-GGCTTGGGTCTCCGGGCG-3' (FRAG. NO:1359)(SEQ. ID NO:1368) 5'-GTTTCCTTCCTTrTCCGC-3' (FRAG. NO:1360)(SEQ. ID NO:1369) TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG TTCCTCCTTG BTCTGGTCGCT GTCGTBCCBG TCGGBCCBGT BB117CBGBTC BTCB17GGCT CCTBTTC'r CTGCBBBCBG CTGBGTGGBG BCBBGBBBBB BGBCTGCCBB GGCCBCGBGG BTTTTCBTGT TGGBTTFTTGC GBCGGBCBGT CCCGCGGGGT GCTGAGTTTC TCTGGTTCCT CCGBGCGCB-3' (FRAG. NO: 1882) (SEQ ID NO: 1895) Substance P Receptor Nucleic Acids and Antisense Oligonucleotide Fragments GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC

TGCCCBBBGG

GGGGBGBGGT

TBCBCBBCCC

CACATCACTA

1Tr7GCCAGGC

GTCCACCGGG

CTGCAGCAGA

TTGTGGGCTC

BCBBMTGCC BGGCTGGT17G CBCGBBCTGB CTGBGTCCBC CGGGBGGBCG TrBTCCBTr CCCTCTGCBG CBGBGTCCTG TCGTGGCGCC CCACGTTGCC CACCACAGAG GTCACCACAA TGGTrGCACG AACTGATTGG GTTCCGAGGT AGGACGTTAT CCATTflCGAA GCTAGGCGGT GTCCTGTCGT GGCGCCTGGG GCTCAGGGTC TTTGGTGGCT GTGGCTGTGG TCTCTGTGGT

BGBGGTCBCC

TrGGGTTCCG

CGBBGCTBGG

TGGGGCTCBG

TGACCGTGTA

GTTAGTGGAG

AAAGCCCTAC

CGTCCTGTCG

TGCTGCCCTG

BCBBTGBCCG

BGGTGTTBGT

CGGTBBBGCC

GGTCCGGGC

GGCAGCTGCC

ATGTITGGGG

TATCTGTACA

TGGCGCCTGG

GGTCTGGGGG

TGTBGGCBGC

GGBGBTG1TT

CTBCTBTCTG

TAAGATGATC

CAAAGGACAA

AGAGGTCTGA

CAACCCCCCT

GGCTCTTCTT

TGTGGCCrrG GGGCCGTCCT CTGGCTCCTC CTCGTGGGCC CCC-3' (FRAG. NO:1883) (SEQ. ID NO:I896) 5'-GGGBGGBCG-3' (FRAG. NO:1884) (SEQ. ID NO:1897) 5'-GGGTC CG-3' (FRAG. NO:1885) (SEQ. ID NO:1898) 259 CCC-3- (FRAG. NO:1886) (SEQ. ID NO:1899) 5'-GTCCTGTCGTGGCGCCTGGGGCTC-3- (FRAG. NO:1361)(SEQ. ID NO:1370) 5'-T'TCTTFI'GTGGGCT-3' (FRAG. NO:1362)(SEQ. ID NO:1371) 5'-CMIGGTGGCTGTGGCTG-3' (FRAG. NO:1363)(SEQ. ID NO:1372) 5'-TGGTCTCTGTGG1TG-3' (FRAG. NO:1364)(SEQ. ID NO:1373) 5'-CTGCCCTGGGTCTGG-3' (FRAG. NO:1365)(SEQ. ID NO:1374) (FRAG.NO:I 366)(SEQ.ID NO: 1375) GATCCACATC ACTACCACGT TGCCCACCAC AGAGGTCACC ACAATGACCG TGTAGGCAGC TGCCCAAAGG ACAATTTGCC AGGCTGGTTG CACGAACTGA TTGGGTTCCG AGGTGTTAGT GGAGATGTTT GGGGAGAGGT CTGAGTCCAC CGGGAGGACG TTATCCATTTC GAAGCTAGGC GGTAAAGCCC TACTATCTGTA CACAACCCCC CTCTGCAGCA GAGTCCTGTC GTGGCGCCTG GGGCTCAGGGTCC-3'(FRAG.NO:1367)(SEQ.ID NO:1376) GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG TGTBGGCBGC TGCCCBBBGG BCBBTTGCC BGGCTGGTTG CBCGBBCTGB TTGGGTTCCG BGGTGTTBGT GGBGBTGTIT GGGGBGBGGTC TGBGTCCBCC GGGBGGBCGT TBTCCBTFTC GBBGCTBGGC GGTBBBGCCC TBCTBTCTGTD CBCBBCCCCC CTCTGCBGCB GBGTCCTGTC GTGGCGCCTG GGGCTCBGGG TCC-3' (FR-AG. NO:1368) (SEQ.ID NO:1377) Chymase Antisense Nucleic Acids and Olijonucleotides Antisense Oliiwnucleotide Fra2ments CTGCBGATTT CBGBGGGBBG BBCCCTGBTB CTCBCCBGCT BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGBGGCTGC C-17TCCBGTC TTGGG1T=B TBBCTCCCBG BBGGCBBGBG BGGGGCBBGG TrTCCTTTFCC TGGCAGTGGG TGGGGGTGGG GGTGGGGTGG CTTCCTTGTT CTGGGCTTTrT CTCCCCT1T[ CCTfCCTGTC TGTTT7CCTG GGGCTCTCCT TGGCCCTCTT CCCTCTCCTG TCTCCTGTCC CTGTGTJTCCG CCCGTC17CC

CTCTCCTGAC

TCTGTGTGTC

TCTTGGGTCC

TCTCTCCATG

GAGGCCAACT

GTTGTCCTGA

TAAACGCACC

TGAGTCTCAC

GGGCAGCATC

CTCCTTTTCC

TTCTTCCTCT

17GGTGCTTG

TCCACTCCCC

CATTTTCTTT

TTTGCTCCCT

CCTGCAGGGT

ATAA1TTTGCC TGCCCTTfCAA TCCGCTGGGT GGGGCCCTGC CTGTfCTCTG G'rrGGCTGGC TTYFCTCCTTC TT1'TGTCTTC GGCTGGG TCCCAG'rrAA TACATAATCA CTGTATCTTG CCATTCTTGA CCTGCATTTC GAAAAACCTG GCATTTCCCA GAAAAAAAAG CTGCCCTrGC 31'CCAAATGT GGTTGGAAAG

TCBGCTCTGG

CTGBGCBBBT

CGTTTTCTTC

CCTGGGGGTG

CTGTCTCTGT

CTCCCTGGCT

CTGGGTGCCC

ATATGCAAYI7 CATCCTCCYI7

TGAAGGGCTG

AAGCACTATT

BGCBCBBGBG

GCTGGTTTTC

TCTCGCTGGT

TCCTCT-1GCT GTCCTrGCCC

TGGGGTTTCT

CY17CTTCCTT

TATTAATACA

ACCTTCCCTA

GGAGCTGTCC

GAAAAATCCC

ACCTGCCTCA

CCTGCATCCT

AATGAGACAC

TCAAGCCATT

ACAGCTTGGC

ACCACTGACA

TGGCTCTACC CTGTAGCCAT CYITCACACT ATCTACCCCA GAGACTAAGG AATCTCCYITG GGACACATGC TGTTGATACC TCAGCCTTAC CAAAACCATA CAACCAAGAA TGACTAGACC GTAATCCCAG TAAGGAGCTA AATCCAGGAA CTATACTCTA AGCCTGTGAG CACCAGCTCC CCTTAAGGC CCCAGCACAA GCAGGACCAT CTAGAATACA TCACAGGAAC CAGAAGTGAA CCAACCACAG ATITAAACAAG CCCCCACAGC CCACACAGAA GTAGGCCTGC CTGAGTGAAT CATCCACATA AAGAGCTTTG TAGCCCATTG CAGAAATGGT TrTAGG'rrrG TGCTGAAGAG AACACTGGGA TAATCTCCAA TGTGCAGAGT GCAGTAATTC

TATAGAAATC

ACTAGAGTAT

GATGATGAGG

CCACAATATG

AGTI1CCTTTC

ATCAGGGCTG

CATCTTGTGG ACCCCTGGGA TGGAAAGAAT AGTTGTTGCC TTATCAACCT AAGATAAAAT CATCATGGCT ACAGTGTrAC AGAAGATGAT GACCCAAGGA GCTGAGAGTG ATAATGGGAG CAGTAGCATC TCAGAGACTA CAGCAGAAAC CCCAAACYI7A TGATAAAGGG CACCCTCAGA GACTCTCCCT ACTTJTAATAT GAGTGGAAAG AGAAATCTTA GGAAGAACCC C11'AAAAAAG CAAAATGCTT CCTGGAAAAG AAATAAGGAC ACACACGCTG AGAAATCTTC CTCCTGCCCC GGATCTCTCC ATATCTCA11T CTCCTGGATA CACTGTCCAC TCAGAAATAT AAAAGTGAGC TATTGTGTTrA GGAGTGAAGG CAAGAGTATC GTAAAATAAA CYTAAAT-fGC TTTATAGATG T-TAATGTAA GCCAGCAGCT ATITAAACGAT ACTTGGTCAT TCAGAAACTA TAGAAACAGG CAGGACTTAT TGCGAGGGCA CTGCTTCAGG AAAATCTGCC AGTGCCATGA AGGATGTACT CTGTCTGCTC TGAGCCCATG CCATCAGCTG TCCCTGACCC ACAGGAGTTC TTTAGAAGAG AGGGTGTT ATACCTGCCA ACTCGAGGGT TAAAACAAGT TGCATAGAAA AGTCATTACT CAGAGAATAA TAAACAGCCT GGCAGCACAT GAATGAATAG AGCATGAAAT AACCAAATTC CATAACAGAT GTITAATCTGT AATGTGTTTA AAGATTTATr CTTTCATCAA AAAAATTATA GCCAATGAGG ATATATCTAT TCAAATTrTGA

AAACCTTAAA

AACACAGAGT

CACTGCACTA

ACTGGTCAAC

TGCTCAATCA

AAAAAAGATG

GGAGAATTTA

AATGAATTCT

'F7CGAGAAAA

GAGCTCCAGC

CTGCTCAGTA

AAAAGTTTCT

AGAAAGACAC

TTACATGCAA

GAGGAAGTAT

CAATTATCCA TCAAGTGGTG ATATGGCAGC ACAAGGTAAA GAACCAATCA TGTGGCATTTF CACAI17GAGC ATCATATTTA TCUTCATAT[ TTATGGATGC AGTAACTAAG GCTGAGAACT

CTAAGTGGCA

AAGTGAATAC

TACTAAGGAA

ACTGTGAATC

AACCACACAT

CCAAGATGCT

GTGCAGCAAA

AATTATTTCC

GCTCCCTCAT

ATGACCTAAA

GAACCAAGAT

TAGCACAGTI7

TCATTGCCAT

AAGACTTGAT

TTATTTTATA

GTAGGATTAT

GGTCCTACTA

ACAAACACTG

GTTACTCCCT

TCAAACTCAC

AATACAATGT

TA1TTTAAATG

TCAACCTCTA

ACAACAGAIT

GTCTAGAGTC

CCACTTGTT

ACCCCTCTAC

TCTAAGTCAA

CCCATCTAAC

TTGGAAACTC

CCAGTGCTTC

CTTGAGTATC

GTTAGTAAGT

AAACTAGCCA

GGCCCAAACA

CAGTCACCGT

ATITGTACACC

ACACAAAGGA

A'ITCTGAAAA

TTAAAATfl17

TGCAGAGCAA

AGAGAAGGAA

TACATCAGGC

TGCCGCAATG

CC'TrCTTAT

GAAGCAATGT

T-rCTAGGCAG

CACTAGAAGA

CC1TrATCTG

A'ITCTACCTT

ATAAAACCAA CGTTTATTFAA AAATCCTTGT ACTGTATCAT TCCTAAGTrC AGACACATAG ACTGCATGCC T-FAAATGTCA TGATCCCTCT GCATTATAGT CCAAATrTrC TGTCCTACTA AGAAATCACT TACCTCCACT ACATACTCAA CAGCTGCTTC CCAAAATACA CCATAACACT CACTGGATAT CTGAATCATC ATFAATTCCA CATGATAATA AUTAACAGAG TCTAAGTCAC AGTAAGGCAA AGTTATCATT ATAAATGGAA AATGTCCACT 'TAAAGTTrC CAAGAACAAA TGCAAGAGAA CTGGGAATGG ACGTT-rGTGG GGGAATTCCT CTAATACAGG AAGGGTGTTC CAGAGACATT AAGGAGCCAT ACAATCCATC AC1TGGTITGC CCCACATCAA CATTCAUTCT TJ7GCCACAC 260

AATTATCCCA

GAAATAACCC

ACAATAGTT

TAAAGTTCAC

CTTAAAATAC

CTGAAATTGG

AAACYJTAAGT

CTCAAThrCT

CTGATGTAAG

CCCGAGAGAA

ACAACAATTT

17CATCTGAA

TGGTACAAGG

AGAGAGTTAG

TACTAAGGAG

AGGCACTTAT

CCACCATGTG

TTATAAGGTG

ATGGTGTGTC

GAGCAAACAC

GTGCTAGAGC

TGATFTAAAA

GAAAGTAATA

AATCCCAATT

CTGAACATAA TCYT-ACTAT CTT'ITATATA AAGGAAAATT AGACTTGACT CAGCAGAACT AGCTCTAACA GTTACTGCTT TTAACTTCAA GTACTGTGTC TCTAGGTGAT ACCTGCTCCA GGTCACAUTT TCAATTf OAT ATTCTCTAGT CTCCCAACTT GATAACTGTA CCCTAAACCA TACCAACATG CTATATATAA AATAACCAAA GGGGGAAGAA GAAAGAGAAA AAGGAAATCT ACAGGTATAC ATATGACAAA GCAAAGAAGG AAATGTGAGC AGATAGTGCA GTCCTCGTTT TCCCCTGACT GGGGCTATAC CTAUTCCATT TCCTCACCCT CAGCCAGGCA GGTGGAGCAA CTTGGTGGAT CTGAATCTTG ATGCTGTGGA GCTGTCTTAC TAGCCCCAGA CTACCTGCCT AATJTATATCA GTGAAAGCAA ACAGCT11TGA TTTGTIFAAG CCTCTGATTT TrTGGTCTAA ACCACAAGGA CAAGAGTTCT CCAGCTCCGG ATTCTCTTCT GTTCTGTTAA TGGTGAAATG GAGTTGCCAA CTTTGGCAAA TAAAAAATAC AGGATJ7CCAG T-rAAATTCAA ATITAGATAA

TTTAGTAYITA

ATACAAATT

ACACTrAAGA

AGCTGTAGGT

TGGATCACTC

ACACTACTCA

GACTGCTTTC

TGTGATCTTT

CCCAGGTTGT

CCIUCTACAT

AGAAAGGGAC

AATTGACTAT

ATATATCTAA

GCTCTTTGCA

GTGTGTCCCA

AACTGGGCAT

AGACCAGATT

AGAACTTGGG

TGGTCACAAG

TCCCCGTCTTr

TGTAAGTCCA

GTCATGTTAA

TGTGGAAAGC

CTTTACTUCC

CTTGATTTGA

CATGACATGA

GAGTTGTGAC

TAAAGTTCTG

TTCAATATTT GGACATACTT AACTAAAAAA TGATTTGTTG TCTGAATA'Ff CTCTGGCAAC CCCCGAGAGA GTGAAGAAAG *TGAAAAGACA TTACGGATGT GT11TAAATGT CTTA11TCTAG AAATTAAGTT AAAAGCAGAC ACAGAGACCT GGCCAATATA CCCAACCTGA GACCAAGGGC ATAGTGAGAT GATTITGGGAA TGAACTAAAT GCCTTFATAAA TCTCCAAGAG AAATGACAGT GGGAAAATAA AAGCTATGTG CTTGAAACCC ACTTCTGATA TGGGTCTGAG TATCAATTCT ACAATTGTAA AGTGACAGTA T7GAT7CTTA ATGCAACAGT AGGAAACCCC AGCCTCTCTG CCTGCACATT GGCAGGACTC TATTFCCTCTA U-TCTCTCTA TATCAGGAAA ATCTATTTCT GAACCATAAG CTATGATAGC TAATGATCAT AATGGTAATA CATATTGATA GGGTITGCCGT AATATATGAT ACGCCTAGAC TCTCAGAAAA TGCTAATTCC TCCTAGGGTC TGTTCTTTTC CCACATCTAC CCTCCYFrGGA AflGAGGAGAG AGATCCAGGT CAATGTTTTT CAAATTACAA AAGTTTJTGAC GTGTAGTGGA ATTGGAGTGG AGTGGAGTGG TCTCTCTTCT GTCTTT-rTCA TGTGGUTCAG GGAATTATCA TTTAAATGGG GAAGAAGCTC AATGGAAACT AACAGGAAGA CACTGCACAT GGTTAAGATA AAGATTGT CCTGAAACCT T-rAATITGTG CTITACATACT CACACATACA TATGTGCATG CACTGGGACT CTGCAATATG CATTI7CTGAC TATGGAACAT AGCCATAAAA GTCTTTGCAC TGAACGTTCA GTGGGCCTTT CACAAGCTGC CCTAATTGGG AAAGAAAAAC ATGGTCCCTC CATTTCCTGC CCCCAACTCC AGAAAAGTCA CCATAGTTGA GGGTACATCT GAGAAGCCAG CACTTGGGAG TrCAGGCTC AAGTTCCTTT CTAGAAAAAC ACTGGGTGAT TCTAGGGGAA CT-rCCGATCA GAAACAGCCA ATTCAGAGTG AGAGAAGAAA ACGTGACCAT GCAGTTCCTG TGGTTACCAG CCTTFGCCCCT CTCTrGCCTT CTGGGAGTTA TAAAACCCAA GACTGGAAAG GAAAACCAGC ATTrGCTCAG GCAGCCTCTC TGGGAAGATG CTGCTTCTfC CTCTCCCCCT GCTGCTCTT CTCTTGTGCT CCAGAGCTGA AGCTGGTGAG TATCAGGGTT CTTCCCTCTG AAATCTGCAG TATCAGCTCC TGAAACAAAG ATGT-rTAGTC TGAAATAGCT GACTCCTAAA CAGGGTTCCA AGATCTCTCT TCAAGAGTCC CACAGAGGAA ATITTCCACTT GGGATGTGTG CCACCCCACC CCCACCCCCA CCCACTGCCA TrCTCTACAG CCTAGGACAC CCCCAGGAAC AAGGAATTTC ACCTCAATTG TAGAAAAGCC CAGAGCAAGT GGAAGGAAAA GGGGTATCCC CAGGAAAACA GACATGTCCT CUTAATCTTC TGAGCATCAG GGCTACCCAT TACT[GTGA CTTCTCACT CTGTGACCAT GCTCAAGAGC TATGGAGAAA TCTAAAACAG GAACCTGGAC AGTGGGTCCT ACACAGAGAC AGAGGAGAGT GGGCCAGGGC AAGGTGGGAG TGGGAGAAGT CTGAGATGAA AACATCAGAA TGGAGCAGAG GCAAGAATGA GATTTCACCT GGGAGGTTAT GGGTGGGGAA AGATACGAAA TACAGGAGAC AGGAGAGGGA AGATGCGG AACACAGGGT GAGAATGAGA TTCCAGGGAA GCCTAGCTCA GCTTTAACCC AATTTGTCCA TTCATTGGAG AGAGTATCTA

TGGCCGTGTT

TCCCGCCCCT

FI7ATAAGACG

TCCAAATGGG

CTGGGTCTY[G

CCTTGAGCCT

TfTGCAGTAGC

CAGGGCCACT

TATGGGAGCA

GGCTGGCCCT

TrCAGTCCCC

AGCCTGAGCC

AGAGTTTAGT

CAAACCCTGG

ACATGGCCTA

GAACTTTGTG

AGATGAACAA

TCAACTTTCA

CAGTCACTGA

ACCCCTCACC

TCCTCTATGG

GAGAACAGGI

CATGCAGGGT

AGCAATTCCA

CTCAAATGCC

CCTCTrTTCT GGTGCTCTGT TCCAGGGGAG ATCATCGGGG CCTGGAAATT GTAACTTCCA ACGGTCCCTC CTGACGGCTG CTCATTGTGC AGGAAGGTGA CCAGAGTAGC ATCCAGGAAT ACACCTGCAC GGAGAGGGAA GACT'FfGGGC TGAAAGACTT GCTAAGCTCC CYITCGGAGGA AAAGGAGGTC CCTACCCAAC TCAAGACACA CGGCTCACTT CCTT1TCAAG AACACTGGCT CTAGTTCTCA F CTACATAAGA CCCCCACTT CCCG1TTTrAA TCCCTGAATT AGGAAGTGTG AACCCTGTCC GGGGTCGTAG AAATTGTGTC TGTTITCCTGA ACAAGTGGCC CATGAAAAGG GAGATGGGTA CAGAATGAGC TCACCTCAGA AGAAACCCCA GCACAGAATG CAAGCCACAT AAAAYITTGT GGTGGT~CC GACAACAGGG TCTATTTATC TGGGGACTGA AGAGGGGGTC TAGTCTGTGT TTGAATAGTT CTGTCCGAAG GTCCCTCTTG TTrCAGGGCCC CACCCAGTCT GGGTCCTGAA CCCATCATT CTGATATCTC CTGCTTCAGG CCTGAGTCCT CCCTGGCCTG GAAAGCTCTT TCATGAGTTA GAGTCCGGCN ACCCAGTGAC AGCCATCACT GTCGCCTCCT T-rTCCTITCCT TCTTCCTCAC AGCAGGTCTA TAACAGTCAC CCT-rGGAGCC CATAACATAA CAGAGGAAGA AGACACATGG CAGAAGCTrG AGGTTATAAA GCAAYTCCGT CATCCAAAAT CACGATATCA TGTTACTAAA GGTGACAACA CCTCTCT-rCT CCCMfCCAC TCcTTCAGGT CCTCATTGCC CTGAATITFT CTTAGGACT GGCTATAACA CTCCCTGATC ACCTCCAACT GTCCAGAGCC CAT-rTCGAGG ACTGACAGTC AAGGAGAAAG CCAGCCTGAC CCTGGCTGTG GGGACACTCC CCTrCCCATC CTGGGAGAAT GTGCCGGGTG GCTGGCTGGG GAAGAACAGG TGTGTTGAAG AGAGGTGAAG CTGAGACTCA TGGATCCCCA GGCCTGCAGC CACYITCAGAG CTGTGTGTGG GCAATCCCAG GAAGACAAAA TCTGCATrTA AGGTGATCCT AAACTCACTG TTCAGGGACC TGAATGCTCT TAGAAGGAGA TGGGGTCAGC GGGTGAGCAT CACAGGAATT GCTGTCCTCC CGTGGTCCAA GACAGCCTCT 261 ATAACACTTC TACTCTTCAC TI'CCCATrCT CCTAAGCTfC TGAAGCTACT CACCCTGTCC CTITCATTCCC TUrCACAGTTG ACAATTCAAC MTGTCCCAC CCGGGCTCAG ACACTCTGCA ACTITGACCA CAATCTTCAG CCAACTAGGT TTCCTCTCCA AGGTTGTCAG TCAGGTGACA GACCATCCAT TCCAGTCTAC TGCACTGGGG GCATGGGGTG ACTGTGGAGA ATGTGGATGA CGGTCCCAAG AAAGGAAGAA GGGGCATCAG AACTAGATGT ATAAGTGAGG AGCTCCACCT CCTGGGTCTG ACTTTAGGTC TCACTGTGAC TCCAAGCTGG CTGGCAGACA GGAGTGGAGG ACTTCCCGGG CTCACCTTCT TCTCTCTCTC CTCCCCCTAC AGGGAGACTC TGGGGGCCCT CTTCTGTGTG CTGGGGTGGC CCAGGGCATC GTATCCTATG GACGGTCGGA TGCAAAGCCC CCTGCTGTCT TCACCCGAAT CTCCCATTAC CGGCCCTGGA TCAAGCAGAT CCTGCAGGCA AATTAATCCT GGATCCTGAG CCAGCCTGAA GGGAAGCTGG AACTGGACCT TAGCAGCAAA GTGTGTGCAA CTCATTCTGG TTFCTACCCTT GGTTCCCTCA GCCACAACCC TAAGCCTCCA AGAGGTCTCC TACAGGTAAC AGAACTTTCA ATAAACTTCA GTGAAGACAC AGCTTCTAGT CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC T-rCTCCTGCA CATGTGACCT GATTCCCAGC CCAAGCACCA AGGA ATCATCGGGG GCACAGAATC CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTrTCC TT1ATAAGACG GAACTTTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTCT ATAACAGTCA CCCTTGGAGC CCATAACATA ACAGAGGAAG AAGACACATG GCAGAAGCTT GAGGTTATAA AGCAATTCCG TCATCCAAAA TATAACACTf CTACTCTTCA CCACGATATC ATGTTACTAA AGTTGAAGGA GAAAGCCAGC CTGACCCTGG CTGTGGGGAC ACTCCCCTFC CCATCACAAT TCAACTTTGT CCCACCTGGG AGAATGTGCC GGGTGGCTGG CTGGGGAAGA ACAGGTGTGT TGAAGCCGGG CTCAGACACT CTGCAAGAGG TGAAGCTGAG ACTCATGGAT CCCCAGGCCT GCAGCCACTT CAGAGACYI7T GACCACAATC TTCAGCTGTG TGTGGGCAAT CCCAGGAAGA CAAAATCTGC AYITAAGGGA GACTCTGGGG GCCCTCT-fCT GTGTGCTGGG GTGGCCCAGG GCATCGTATC CTATGGACGG TCGGATGCAA AGCCCCCTGC TGTCTTCACC CGAATCTCCC ATTACCGGCC CTGGATCAAC CAGATCCTGC AGGCAAATA A-3' (FRAG. NO:1887) (SEQ. ID NO:3015) 5'-ATCATCGGGG GCACAGAATC CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC TTATAAGACG GAACTTITGTG CTGACGGCTG CTCATfGTGC AGGAAGGTCT ATAACAGTCA CCCYITGGAGC CCATAACATA ACAGAGGAAG AAGACACATG GCAGAAGCTT GAGGTTATAA AGCAATTCCG TCATCCAAAA TATAACACTT CTACTCTTCA CCACGATATC ATGTTACTAA AGTTGAAGGA GAAAGCCAGC CTGACCCTGG CTGTGGGGAC ACTCCCCFITC CCATCACAAT TCAACTTTGT CCCACCTGGG AGAATGTGCC GGGTGGCTGG CTGGGGAAGA ACAGGTGTGT TGAAGCCGGG CTCAGACACT CTGCAAGAGG TGAAGCTGAG ACTCATGGAT CCCCAGGCCT GCAGCCACTT CAGAGACTTr GACCACAATC YFCAGCTGTG TGTGGGCAAT CCCAGGAAGA CAAAATCTGC ATTTAAGGGA GACTCTGGGG GCCCTC'TTCT GTGTGCTGGG GTGGCCCAGG GCATCGTATC CTATGGACGG TCGGATGCAA AGCCCCCTGC TGTCT-rCACC CGAATCTCCC ATTACCGGCC CTGGATCAAC CAGATCCTGC AGGCAAATTA A-3'(FRAG.NO:)(SEQ.ID NO:2468) 5'-TCCCAGTTAA TACATAATCA ATATGCAATT TATTAATACA TCTCTCCATG TCCACTCCCC CTGTATCTTG CCATTCYI7GA

GCATTTCCCA

TTCCAAATGT

CTGTAGCCAT

ATCTACCCCA

AATCTCCTTG

CGACAATATG

AGTTCCTTrTC

ATCAGGGCTG

ACCCGTGGGA

CATCATGGCT

ATAATGGGAG

TGATAAAGGG

AGAAATCTTA

AAATAAGGAC

CCTGCAYFTC CATCCTCCTT ACCTTCCCTA GAGGCCAACT CATTCTrrT GAAAAACCTG GAAAAAAAAG TGAAGGGCTG GGAGCTGTCC GTTGTCCTGA TTTGCTCCCT CTGCCCT7GC GGTTGGAAAG AAGCACTATT GAAAAATCCC TAAACGCACC CCTGCAGGGT TGGCTCTACC GGACACATGC TGTTGATACC ACCTGCCTCA TGAGTCTCAC ATAATTTGCC CTrrCACACT TCAGCCTTAC CAAAACCATA CCTGCATCCT GGGCAGCATC TGCCCTTCAA GAGACTAAGG CAACCAAGAA TGACTAGACC AATGAGACAC CC'F=TAAGGC CCCAGCACAA TATAGAAATC GTAATCCCAG TAAGGAGCTA TCAAGCCATT GCAGGACCAT CTAGAATACA ACTAGAGTAT AATCCAGGAA CTATACTCTA ACAGCTTGGC TCACAGGAAC CAGAAGTGAA GATGATGAGG

AGCCTGTGAG

TGGAAAGAAT

ACAGTGTTAC

CAGTAGCATC

CACCCTCAGA

GGAAGAACCC

ACACACGCTG

CACCAGCTCC

AGTTGTTGCC

AGAAGATGAT

TCAGAGACTA

ACCACTGACA CCAACCACAG ATTAAACAAG CATCTTGTGG TTATCAACCT CCCCCACAGC CCACACAGAA AAGATAAAAT GACCCAAGGA GTAGGCCTGC CTGAGTGAAT GCTGAGAGTG CAGCAGAAAC CATCCACATA AAGAGCTYITG CCCAAACTTA GACTCTCCCT ACTTTAATAT CTTAAAAAAG CAAAATGCTT AGAAATCTrC CTCCTGCCCC

ATATCTCATT

TATTGTGTTA

YITTATAGATG

TCAGAAACTA

AAAATCTGCC

CCATCAGCTG

ATACCTGCCA

CAGAGAATAA

AACCAAATTC

CTTrTCATCAA CTCCTGGATA CACTGTCCAC TCAGAAATAT GGAGTGAAGG CAAGAGTATC GTAAAATAAA TTTAATGTAA GCCAGCAGCT ATTAAACGAT

TAGAAACAGG

AGTGCCATGA

TCCCTGACCC

ACTCGAGGGT

TAAACAGCCT

CATAACAGAT

AAAAATTATA

CAGGACTTAT TGCGAGGGCA AGGATGTACT CTGTCTGCTC ACAGGAGTTC TTTAGAAGAG TAAAACAAGT TGCATAGAAA GGCAGCACAT GAATGAATAG GTTAATCTGT AATGTGTA GCCAATGAGG ATATATCTAT TAGCCCATTG CAGAAATGGT GAGTGGAAAG T-JTAGGTTTG TGCTGAAGAG CCTGGAAAAG AACACTGGGA TAATCTCCAA GGATCTCTCC TGTGCAGAGT GCAGTAATTC AAAAGTGAGC TCAAATTTGA AATGAATTCT CTTAAATTGC AAACCTTAAA TTCGAGAAAA ACTITGGTCAT AACACAGAGT GAGCTCCAGC CTGCTF[CAGG CACTGCACTA CTGCTCAGTA TGAGCCCATG ACTGGTCAAC AAAAGTTTCT AGGGTGTT[ TGCTCAATCA AGAAAGACAC AGTCATTACT AAAAAAGATG TTACATGCAA AGCATGAAAT GGAGAATTTA GAGGAAGTAT AAGATTTA~r CAATTATCCA TCAAGTGGTG ATATGGCAGC GAACCAATCA TGTGGCATrrT CACATTGAGC TCTCATATr YI7ATGGATGC AGTAACTAAG CTAAGTGGCA GAACCAAGAT TCAAACTCAC AAGTGAATAC TAGCACAGTT AATACAATGT TACTAAGGAA TCATTrGCCAT TA1TfAAATG ACTGTGAATC AAGACTTGAT TCAACCTCTA ACAAGGTAAA ACACAAAGGA ATAAAACCAA CGTTATAA ATCATATTTA AYI7CTGAAAA

GCTGAGAACT

CCCATCTAAC

YUGGAAACTC

CCAGTGCTTC

CTUGAGTATC

GTTAGTAAGT

AAACTAGCCA

GGCCCAAACA

CAGTCACCCT

TTAAAATT=

TGCAGAGCAA

AGAGAAGGAA

TACATCAGGC

TGCCGCAATG

CCT17rCTTAT

GAAGCAATGT

TTCTAGGCAG

CACTAGAAGA

AAATCCTTGT ACTGTATCAT TCCTAAGTTC AGACACATAG ACTGCATGCC TrAAATGTCA TGATCCCTCT GCATTATAGT CCAAAYITC TGTCCTACTA AGAAATCACT TACCTCCACT ACATACTCAA CAGCTGCTTC CCAAAATACA CCATAACACI CACTGGATAT CTGAATCATC ATTAATTCCA CATGATAATA AACCACACAT TTAT1TTATA CCAAGATGCT GTAGGATTAT GTGCAGCAAA GGTCCTACTA AA'rATrCC ACAAACACTG GCTCCCTCAT GTTACTCCCT

ACAACAGATT

GTCTAGAGTC

CCACTTGTTT

ACCCCTCTAC

TCTAAGTCAA

ATTGTACACC CCTrATCTG ATTAACAGAG TCTAAGTCAC ATGACCTAAA TGCAAGAGAA 262

CTGGGAATGG

ACGTTTGTGG AUTCTACCT[ AGTAAGGCAA AGTrATCATr GGGAATTCCT CTAATACAGG AAGGGTGTTC CAGAGACATT AAGGAGCCAT ATAAATGGAA AATGTCCACT CATITCATTCT TTTGCCACAC TTAAAGTTTC CAAGAACAAA C1TTTTATATA AAGGAAAATT AGACTTGACT CAGCAGAACT TTAACTTCAA GTACTGTGTC TCTAGGTGAT ACCTGCTCCA ATTCTCTAGT CTCCCAACTT GATAACTGTA CCCTAAACCA AATAACCAAA GGGGGAAGAA GAAAGAGAAA AAGGAAATCT GCAAAGAAGG AAATGTGAGC AGATAGTGCA GTCCTCGTTT CTATTCCATT TCCTCACCCT CAGCCAGGCA GGTGGAGCAA ATGCTGTGGA GCTGTCTfAC TAGCCCCAGA CTACCTGCCT

ACAATCCATC

AATTATCCCA

GAAATAACCC

ACAATAGTTT

TAAAGTTCAC

CTrAAAATAC

CTGAAATTGG

AAACTTAAGT

CTCAATTTCT

ACAGCTTTGA

CCAGCTCCGG

TAAAAAATAC

FCAATATTr

TCTGAATATT

TGAAAAGACA

AAATTAAGTT

CCCAACCTGA

TGAACTAAAT

GGGAAAATAA

TGGGTCTGAG

TTGATTCTTA

CCTGCACATT

TATCAGGAAA

TAATGATCAT

AATATATGAT

TCCTAGGGTC

UTTGT1TTAAG CCTCTGATT-r TTTGGTCTAA CTGATGTAAG ATTCTCTTCT GTTCTGTTAA TGGTGAAATG CCCGAGAGAA AGGATTCCAG TTAAArrCAA ATTTAGATAA ACAACAATTr GGACATACTT AACTAAAAAA TGATTTGTTG TTCATCTGAA CTCTGGCAAC CCCCGAGAGA GTGAAGAAAG TGGTACAAGG TrACGGATGT GT[AAATGT CTTATTCTAG AGAGAGTTAG ACT'TGGTTrGC CCCACATCAA CTGAACATAA TCT~rACTAT AGCTCTAACA G11TACTGCTT GGTCACAT TCAATTTGAT TACCAACATG CTATATATAA ACAGGTATAC ATATGACAAA TCCCCTGACT GGGGCTATAC CTTGGTGGAT CTGAATC~rG AATTATATCA GTGAAAGCAA ACCACAAGGA CAAGAGTTCT GAGTTGCCAA CTTTGGCAAA TUTAGTATTA GTGTGTCCCA ATACAAATTT AACTGGGCAT ACACTTAAGA AGACCAGATT AGCTGTAGGT AGAACTTGGG TGGATCACTC TGGTCACAAG ACACTACTCA TCCCCGTCTT GACTGCTTTC TGTAAGTCCA TGTGATC'rrT GTCATGTTAA AAAAGCAGAC ACAGAGACCT GGCCAATATA GACCAAGGGC ATAGTGAGAT GATITGGGAA GCCTTATAAA TCTCCAAGAG AAATGACAGT AAGCTATGTG CTTGAAACCC ACTrCTGATA

TACTAAGGAG

AGGCACTTAT

CCACCATGTG

TfATAAGGTG

TATCAATTCT

ATGCAACAGT

GGCAGGACTC

ATCTAT'TTCT

AATGGTAATA

ACGCCTAGAC

TGTTCTTTTC

ACAATTGTAA AGTGACAGTA ATGGTGTGTC CCCAGGTTGT TGTGGAAAGC AGGAAACCCC AGCCTCTCTG GAGCAAACAC CCTTCTACAT CTrTACTTCC AGGAGGAGAG AGATCCAGGT

TATTCCTCTA

GAACCATAAG

CATATTGATA

TCTCAGAAAA

CCACATCTAC

CAATGTTTI7

ATTGGAGTGG

CCTGAAACCT

CATTTCTGAC

CCTAATrGGG

GGGTACATCT

TTrTCTCTCTA(

CTATGATAGC

GGGTTGCCGT

TGCTAATTCC

CCTCCTrGGA

CAAATTACAA

AGTGGAGTGG

TTAATTTGTG

TATGGAACAT

AAAGAAAAAC

GAGAAGCCAG

3TGCTAGAGC

TGATTTAAAA

GAAAGTAATA

AATCCCAATT

TCTCTCTTCT

GGAATTATCA

AATGGAAACT

CTTACATACT

AGCCATAAAA

ATGGTCCCTC

AGAAAGGGAC

AATTGACTAT

ATATATCTAA

GCTCTTTGCA

GTCTTJTTTCA

17TAAATGGG

AACAGGAAGA

CACACATACA

GTCTTTGCAC

CATTTCCTGC

CTTGAT-17GA

CATGACATGA

GAGTTGTGAC

TAAAGTTCTG

TGTGGT-FCAG

GAAGAAGCTC

CACTGCACAT

TATGTGCATG

TGAACGTTCA

CCCCAACTCC

AAGTT'rrGAC

GGTTAAGATA

CACTGGGACT

GTGGGCCYT-

AGAAAAGTCA

CTAGAAAAAC

ACGTGACCAT

GACTGGAAAG

GCTGCTCTTT

TATCAGCTCC

TCAAGAGTCC

GTGTAGTGGA

AAGATTGfTF

CTGCAATATG

CACAAGCTGC

CCATAGT7GA CACTTGGGAG TTCAGGGCTC AAG17CCTT-T ACTGGGTGAT TCTAGGGGAA CTTCCGATCA GAAACAGCCA ATTCAGAGTG AGAGAAGAAA GCAGTTCCTG TGGTTACCAG CC'ITGCCCCT CTCT-rGCCY-F CTGGGAGTTA TAAAACCCAA GAAAACCAGC ATTTGCTCAG GCAGCCTCTC TGGGAAGATG CTGCYI7CTTC CTCTCCCCCT CTCTTGTGCT CCAGAGCTGA AGCTGGTGAG -TATCAGGGTT CTTCCCTCTG AAATCTGCAG TGAAACAAAG ATGTTT1AGTC TGAAATAGCT GACTCCTAAA CAGGGYFCCA AGATCTCTCT CACAGAGGAA ATTTCCACT-F GGGATGTGTG CCACCCCACC CCCACCCCCA CCCACTGCCA TI1TcTCTACAG CCTAGGACAC CCCCAGGAAC AAGGAATTTC ACCTCAATTG TAGAAAAGCC CAGAGCAAGT GGAAGGAAAA GGGGTATCCC CAGGAAAACA GACATGTCCT C'FrAATCTTC TGAGCATCAG GGCTACCCAT TACTTTGTGA CTTTCTCACT CTGTGACCAT GCTCAAGAGC TATGOAGAAA TCTAAAACAG GAACCTGGAC AGTGGGTCCT ACACAGAGAC AGAGGAGAGT GGGCCAGGGC AAGGTGGGAG TGGGAGAAGT CTGAGATGAA AACATCAGAA TGGAGCAGAG GCAAGAATGA GATTTCACCT GGGAGGTTAT GGGTGGGGAA AGATACGAAA TACAGGAGAC AGGAGAGGGA AGATGGGCGG AACACAGGGT GAGAATGAGA TTCCAGGGAA GCCTAGCTCA GCTTTAACCC AATTTGTCCA TTCATTGGAG AGAGTATCTA TGGCCGTGTT CAAACCCTGG GGTGCTCTGT TCCAGGGGAG ATCATCGGGG GCACAGAATG CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAAT-r

GTAACTTCCA

CTCA11TGTGC

ATCCAGGAAT

GACTTTGGGC

CTTCGGAGGA

TCAAGACACA

AACACTGGCT

CCCCCACYT

ACGGTCCCTC

AGGAAGGTGA

ACACCTGCAC

TGAAAGACTT

AAAGGAGGTC

CGGCTCACTT

CTAGTTCTCA

CCCGTTTJTAA

AAAATTTTGT GGTGGTTTCC TTATAAGACG GACAACAGGG TCTATTTATC TCCAAATGGG TGGGGACTGA AGAGGGGGTC CTGGGTCTTG TAGTCTGTGT 31TGAATAGTT CCTrGAGCCT CTGTCCGAAG GTCCCTCTTG TFGCAGTAGC 1TCAGGGCCC CACCCAGTCT CAGGGCCACT GGGTCCTGAA CCCATCATTT TATGGGAGCA CTGATATCTC CTGCTTCAGG GGCTGGCCCT CCTGAGTCCT CCCTGGCCTG TTCAGTCCCC GAACTTTGTG CTGACGGCTG AGATGAACAA CCAGAGTAGC TCAACTTTCA GGAGAGGGAA CAGTCACTGA GCTAAGCTCC ACCCCTCACC CCTACCCAAC TCCTCTATGG CCTrCAAG GAGAACAGGT CTACATAAGA CATGCAGGGT TCCCTGAATr AGCAATITCCA GGGGTCGTAG CTCAAATGCC ACAAGTGGCC AGGAAGTGTG AACCCTGTCC AAATTGTGTC TGTTTCCTGA GAAAGCTCT-r TCATGAG'rrA AGCCTGAGCC CATGAAAAGG GAGATGGGTA GAGTCCGGCN ACCCAGTGAC AGAGTTTAGT CCTCTITCT CAGAATGAGC TCACCTCAGA AGAAACCCCA AGCCATCACT GTCGCCTCCT TrTCCTTCCT TCT-rCCTCAC AGCAGGTCTA TAACAGTCAC CCYJ7GGAGCC CATAACATAA CAGAGGAAGA AGACACATGG CAGAAGCTTG AGGTTATAAA GCAATITCCGT CATCCAAAAT ATAACACTTC TACTC'FrCAC CACGATATCA TGTTACTAAA GGTGACAACA CCTCTCT'TCT CCC1CCAC TTCCCATTCT CCTAAGCTTC TCCTTCAGGT CCTCATTGCC CTGAATTTr CTTAGGACTr GGCTATAACA TGAAGCTACT CACCCTGTCC CTCCCTGATC ACCTCCAACT GTCCAGAGCC CATTTCGAGG ACTGACAGTC CTTCATTCCC TrCACAGT7G AAGGAGAAAG CCAGCCTGAC CCTGGCTGTG GGGACACTCC CCTTCCCATC ACAATTCAAC TTGTCCCAC CTGGGAGAAT GTGCCGGGTG GCTGGCTGGG GAAGAACAGG TGTGTTGAAG CCGGGCTCAG ACACTCTGCA AGAGGTGAAG CTGAGACTCA TGGATCCCCA GGCCTGCAGC CAC'ITCAGAG AC1TTTGACCA CAATCTTCAG CTGTGTGTGG GCAATCCCAG GAAGACAAAA 263 TCTGCATTTA AGGTGATCCT CCAACTAGGT TTCCTCTCCA AAACTCACTG TTCAGGGACC TGAATGCTCT TAGAAGGAGA TGGOGTCAGC AGGTTGTCAG TCAGGTGACA GGGTGAGCAT CACAGGAATf GCTGTCCTCC CGTGGTCCAA GACAGCCTCT GACCATCCAT TCCAGTCTAC TGCACTGGGG GCATGGGGTG ACTGTGGAGA ATGTGGATGA CGGTCCCAAG AAAGGAAGAA GGGGCATCAG AACTAGATGT ATAAGTGAGG AGCTCCACCT CCTGGGTCTG AcTTTrAGGTC TCACTGTGAC TCCAAGCTGG CTGGCAGACA GGAGTGGAGG ACYI7CCCGGG CTCACCUTCT TCTCTCTCTC CTCCCCCTAC AGGGAGACTC TGGGGGCCCT CTTCTGTGTG CTGGGGTGGC CCAGGGCATC GTATCCTATG GACGGTCGGA TGCAAAGCCC CCTGCTGTCT TCACCCGAAT CTCCCATTAC CGGCCCTGGA TCAACCAGAT CCTGCAGGCA AATTAATCCT GGATCCTGAG CCAGCCTGAA GGGAAGCTGG AACTGGACCT TAGCAGCAAA GTGTGTGCAA CTCATTCTGG TTCTACCCTT GGTTCCCTCA GCCACA-ACCC TAAGCCTCCA AGAGGTCTCC TACAGGTAAC AGAACTTTCA ATAAACTrCA GTGAAGACAC AGCTTCTAGT CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC 'I7CTCCTGCA CATGTGACCT GAT-rCCCAGC CCAAGCACCA AGGA- 3' (FRAG. NO:) (SEQ. ID NO:2467) 5'-GGBGCBCBBG-3' (FRAG. NO:1888) (SEQ. ID NO:1901) 5'-GBBGCBGC-3' (FRAG. NO:1889) (SEQ. ID NO:1902) 5'-GGGGCBBGG CG-3' (FRAG. NO:1890) (SEQ. ID NO:1903) 5'-CGTTTrTCTTCTCTC-3- (FRAG. NO:1369)(SEQ. ID NO:1378) 5'-GCTGGTT-FTCCTTU1CC-3' (FRAG. NO:1370)(SEQ. ID NO:1379) 5'-TGGCAGTGGGTGGGGGTGGGGGTGGGGTGGC-3 (FRAG. NO:1371)(SEQ. ID NO:1380) 5'-YfrCCT-fGTTCCTGGGGGTGTCCT-3 (FRAG. NO:1372)(SEQ. ID NO:1381) 5'-CYTGCTCTGGGCT-fTTCT-3 (FRAG. NO: 1 373)(SEQ. ID NO: 1382) 5'-CCCC1TrCCTTCC-3' (FRAG. NO:1I374)(SEQ. ID NO: 1383) 5'-TGTCTGTTT-rCCTGGGG-3' (FRAG. NO: 13 75)(SEQ. ID NO: 1384) 5'-CTCTCCTCTGTCTCTGTGT-3 (FR AG. NO:1I376)(SEQ. ID NO:I1385) 5'-CCT-fGCCCTGGCCC-3 (FRAG. NO:1I377)(SEQ. ID NO: 1386) 5'-TC~rcCCTCTCCTGTCTCCTGT-3 (FRAG. NO: I 378)(SEQ. ID NO: 1387) 5'-CCCTGTGTTCCGCCC-3 (FRAG. NO:1379)(SEQ. ID NO:1388) 5'-GTCVI'CCCTCTCCTG-3 (FRAG. NO: 13 80)(SEQ. ID NO:I1389) 5'-ACCTCCTMCCTCCG-3 (FRAG. NO: 138 1)(SEQ. ID NO: 1390) S'-CTGGGTGGGGCCCTG-3 (FRAG. NO:1382)(SEQ. ID NO:1 391) 5'-CCTGTTCTCTGCTCCC-3' (FRAG. NO: I 383)(SEQ. ID NO: 1392) 5'-TGGCTTGGGGTTTCTTCTG-3' (FRAG. NO:13 84)(SEQ. ID NO: 1393) 5'-TGTGTCTTCTTCCTCTGTTr-3'(FRAG. NO: 1385)(SEQ. ID NO: 1394) 5'-GGCTGGCTTTCTCCTTC-3* (FRAG. NO: I386)(SEQ. ID NO: 1395) 5'-1TIGTCTfrCCTGGG-3- (FRAG. NO:1I387)(SEQ. ID NO: 1396) [1397)] 5'-TGccccT-rcTfCCTfTCTTGGG-3 (FRAG. NO 1388)(SEQ. ID NO: 1397) 5'-TCCITGGTGCTTFGGGCTGGG-3 (FRAG. NO:1I389)(SEQ. ID NO: 1398) CTGCBGATTU CBGBGGGBBG BBCCCTGBTB CTCBCCBGCT TCBGCTCTGG BGCBCBBGBG BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGBGGCTGC CTGBGCBBBT GCTGGTTTTC CTTTCCBGTC TTGGG1TrT TBBCTCCCBG BBGGCBBGBG BGGGGCBBGG-3' (FRAG.NO:1891) (SEQ.ID NO:1 904) Endothelial Nitric Oxide Synthase Nucleic Acids and Antisense Oligonucleotide Fragments GTGCBGGGCC CBTCCTGCTG CGCCTGGGCG CTGCTGTGCG TCCGTCTGCT GGGGGGCCGG

GGTGGCTGGG

GTGGGCTTGG

CGGGGGGCCG

GCCGTCCTGC

TCCTCGTGCC

TCGGGGTCTG

TCGGGCGTCT

CCGCTCGTCG

GCTGCCTCTG

CCTCCTGGCC

CCCTGCTTGC

GCCCCTCTGG

GGGGGCCGCT

TGCCGGTCGT

GCTGCTGCCT

GCTGGTTGCC

CGTGTTCGCT

CCCTGGCCCG

GCGCT17CCGG

TCCGGTGTCC

CGCACGACCC CGGGCCGACC CGAGGCTCGG GGGGCTGTGT GGGCTGGGTT TCCTGCTGCG CCTGGGCGCT GGCGTCTTGG GTTCGTGGGC CTGGGGGTGC CTGTGGCTGC CGGTTGCCCC TGGCTGGGTC CCCCCGCCCG 1TTCCTGGGG TGTCTTTCCG GCCGTGGCGG CGTGGTGGTC GGTGCCCTTG GCGGCGGTCT TCTTCCTGGT CYI7GTGCTGT TCCGGCCGCT CCY1TCCTCTT GCCTCCTCCT GGCCGCTGTC TCGGGCGGCG CCCTCGGCCT GGGCGCTCTC TTCCGCCTGT TGTGGTCCCC CGGCTGGTGG CCGGGCCGGT CGGGTCCTCC GGGCTGCCCT TCTCCGCCGG TCTCCTGGGT GGGTGCTGGG TGCCGGGGTC GGGTTGTCTG TGGCCCCGCT CGTGTCGCCC GGCGGGCTGG TCCTGGCGTT TTGCTCCT7C GGCGCTGCTG TGCGTCCGTC TGCTGGGGGG GACCCGAGGC TCGGGGGGCT GTGTTCTGGC TGCGCCTGGG CGCTGGCGTC TTrGGGGTGCG GTGCCTGTGG CTGCCGGTTG CCCCGGTTGG CCCGTCCT GGGGTCCGCG TGGGGTGCTC GCGGCGTGGT GGTCCGCCCC CCCTGGCCYr GTCTTCTTCC TGGTGGCTCT GGGCCCGGCC CGCTCCT7CC TCT[CCGCCG CCGCCGCTCC TGTCTCGGGC GGCGGCCT7G GCGCTCCGYI7 TCTCTTCCGC CTGTGCTGGT GGCCCTCGTG

GGGTCCCGCG

TCCGGGCTUG

TCCGTCGCCC

CTGGGCGTCT

CCGGGGTGGC

GCTGGTGGGC

GGGCCGGGGG

TGGCGCCGTC

CGG'TrCCTCG

CTGCTCGGGG

GGTCTCGGGC

CCGCCCGCTC

TGGGGCTGCC

GGCCCCTCCT

264

CTCCTGCTGT

CCCCGCGCTG

GTCGCCGGCC

TGGGGTGCBG

TGGGCCCTGC

TTGGcCCCT

GCCGGGGGGC

CTGCTGCCGG

TGCCGCTGCT

TCTGGCTGGT

GTCTCGTGTT

GTCGCCCTGG

TCTGGCGCTT

GGCCTCCGGT

TCCGCGTGGG

CGCCCCCCCT

GGCTCTGGGC

CCGCCGCCGC

GCCTTrGGCGC

GCTGGTGGCC

rGGGCGGGCG

TCCCTGGGCT

CTGGGCGTTC

TCGTCCCCTC

GGCCCBTCCT

TTrGCCGCACG

CTGGGGGCTG

CGCTGTTCGT

TCGTTGGCTG

GCCTTFGTCTT

TGCCGGTGCC

CGCTCTTGTG

CCCGGCCTCC

CCGGCCCTCG

GTCCTGTGGT

TCTGGCGCTG

GGTGCGGGGC

GGTTGGTGGC

GTGCTCCGGT

GGCCTTCTGC

CCGGCCGGTC

CGCTCCCCGC

TCCGTTTGGG

CTCGTGGGCC

TGGGCGCCGG

CT-rCTGCCTC

TGCGGTCTTG

CTGGGTGCGC

GCTGCGCCTG

ACCCCGGGCC

GGTTTCCTGC

GGGCCTGGGG

GGTCCCCCCG

TCCGGCCGTG

CTTGGCGGCG

CTGT-rCCGGC

TCCTGGCCGC

GCCTGGGCGC

CCCCCGGCTG

GTGGCCGGGC CGGTTGGGCG GGCGTGGGCG CCGGCGGGTC CTCCGGGCTG CCCTrCTCCG CCGGGTCC CGCGCTCCTG CTGT1TCCCTG GGCTCTTCTG CCTCTCTCCT GGGTGGGTGC TGGGTGCCGG GGTCTCCGUG CT-TGCCCCGC GCTGCTGGGC GT1TCTGCGGT CTrGGGGTTG TCTGTGGCCC CGCTCGTGTC GCCCTCCGTC GCCCGTCGCC GGCCTCGTCC CCTCCTGGGT GCGCGGCGGG CTGGTCCTGG CGTTTCTC C'TrCCTGG-3.

(FRAG. NO:1892) (SEQ. ID NO: 1905) 5'-GCUGUCCG-3- (FRAG. NO:1893) (SEQ. ID NO: 1906) 5'-CGGGGGGC-3' (FRAG. NO:1894) (SEQ. ID NO: 1907) 5'-GCGCGGCGGGC-3' (FRAG. NO:1895) (SEQ. ID NO: 1908) (FRAG. NO: 1390)(SEQ. ID NO: 1399) GGGGCCGGGGTGGCTGGCCCTGCTTGCCGC (FRAG. NO: 139 1)(SEQ. ID NO: 1400) ACGACCCCGGGCCGACCCGAG (FRAU. NO: I 392)(SEQ. ID NO: 1401) GCTCGGGGGGCTGTGTFCTGGCGCTGGTGGG (FRAG. NO:1I393)(SEQ. ID NO: 1402) C7[lGGGCCCCTGTGUGGGCTGGGTT (FRAG. NO: I394)(SEQ. ID NO: 1403) TCCTGCTGCGCCTUGGCGCTG (FRAG. NO: I 395)(SEQ. ID NO: 14041) GCGTCTTUGGGTGC (FRAG. NO: I396)(SEQ. ID NO: 1405) GGGGCCGGGGCCGGGGU (FRAU. NO: I 397)(SEQ. ID NO: 1406) UCCUCTGTTCGTGGGCCTGGG (FRAU. NO:1I398)(SEQ. ID NO: 1407) GGTUCCTGTGGCTGCC (FRAG. NO:1I399)(SEQ. ID NO: 1408) GGTTGCCCCGGTTGGTGGC (FRAG. NO: 1400)(SEQ. ID NO: 1409) GCCGTCCTGCTGCCGGT (FRAU NO: 140 1)(SEQ. ID NO: 14 CGTTGGCTGGGTCCCCCCGC (FRAG. NO: 1402)(SEQ. ID NO: 141 1) CCGTUrCCTGGGGTCC (FRAG. NO: 1403)(SEQ. ID NO: 1412) GCUTUGGGGTGCTCC (FRAG. NO: 1 404)(SEQ. ID NO: 1413) GGTTCCTCGTGCCG (FRAG. NO: I 405:)(SEQ. ID NO: 1414) CTGCTGCCTTGTCTTTCC (FRAU. NO: 1406)(SEQ. ID NO: 1415) UGCCUTGGCGGCGTGUTUUTCC (FRAG. NO: I 407)(SEQ. ID NO: 1416) GCCCCCCCTGGCCTTCTGCTC (FRAU. NO: 1 408)(S EQ. ID NO: 1417) GUGTCTGUCTGGT (FRAG. NO: I409)(SEQ. ID NO: 141 8) TGCCGGTGCCCTI1GGCGGC (FRAG. NO: 14 1 0)(SEQ. ID NO: 1419) GGTCT-lCTCCTGGTG (FRAG. NO: 141 1)(SEQ. ID NO: 1420) GCTCTGGGCCCGGCCGGTCTCUG (FRAU. NO: 141 2)(SEQ. ID NO: 1421) UCGTCTCGTGTTrCU (FRAU. NO: 1413)(SEQ. ID NO: 1422) CTCT1'GTGCTGTTCCGGCCG (FRAG. NO:1I414)(SEQ. ID NO: 1423) CTCCT-TCCTC'I1CCGCCGCC (FRAG. NO:1I415)(SEQ. ID NO: 1424) UCCGCTCCCCUCCC (FRAU. NO.1I416)(SEQ. ID NO: 1425) GCTCUTCGCCCTGGCCC (FRAG. NO: 1417)(SEQ. ID NO: 1426) GGCCTCCTCCTGUCCGC (FRAU. NO: 1418)(SEQ. ID NO: 1427) TGTCTCGGGCGGCGGCCTTGGC (FRAG. NO: 1419)(SEQ. ID NO: 1428) GCTCCGTTTGGGGCTG (FRAU. NO: I420)(SEQ. ID NO: 1429) CCTCTGGCGCTTCC (FRAG. NO: 142 1)(SEQ. ID NO: 1430) GGCCCTCGUCCTGGUCGCTC (FRAG. NO: I 422)(SEQ. ID NO: 143 1) TCTTCCUCCTUTUC (FRAG. NO: 1423)(SEQ. ID NO: 1432) TGGTGGCCCTCGTGG (FRAU. NO: 1424)(SEQ. ID NO: 1433) UCCCCTCCTGGCCTCCGGTUTCC (FRAG. NO: 1425)(SEQ. ID NO: 1434) TUTGGTCCCCCGGCTUUT (FRAU. NO:1I426)(SEQ. ID NO: 1435) GGCCGCCGGTTGGGCUGGC (FRAU. NO: I 427)(S EQ. ID NO: 1436) GTGUGCGCCGGCGUGTCCTCC (FRAU. NO: I 428)(SEQ. ID NO: 1437) UUUCTUCCCT17CTCC (FRAU. NO:1I429)(SEQ. ID NO: 1438) GCCUUUUUTCCCUC (FRAU. NO: I 430)(SEQ. ID NO: 1439) GCTCCTGCTUTTCCCTUGGCTCT-rCTGCC (FRAU. NO: 143 1)(SEQ. ID NO: 1440) TCTCTCCTUUUTUUUTUCTUUUTUCCU (FRAU. NO: 1432 )(SEQ. ID NO: 144 1) UUUTCTCCUUUCTTG (FRAU. NO: I 433)(SEQ. ID NO: 1442) CCCCUCUCTUCTUUUCUTTCTUC (FRAU. NO: 1434)(SEQ. ID NO: 1443) UGTCTTUUUUTTGTC (FRAU. NO: 1435)(SEQ. ID NO: 1444) TUTUGCCCCUCTCU (FRAU. NO:1I436)(SEQ. TO NO: 1445) TUTCGCCCTCCUTCUCC (FRAU. NO: 1437)(SEQ. ID NO: 1446) CUTCGCCUUCCTCUTCC (FRAU. NO: 1 438)(SEQ. ID NO: 1447) CCTCCTUUUTUCUC (FRAU. NO:1I439)(SEQ. ID NO: 1448) UUCUUUCTUUTCCT (FRAU. NO: 1440)(SEQ. ID NO: 1449) UUCTTUrcTCCTTCCTUU (FRAU. NO: 144 1)(SEQ. ID NO: 1450) 5'-UCUTCTTUUUUTUCBUUUCCCBTCCTUCTUCUCCTUUUCGCTU-3'(FRAG. NO: 1896) (SEQ. ID NO: 1909) Inducible Nitric Oxide Synthase Nucleic Acids and Antisense Oligonucleotide Fragments TITGBTCCT CBCBTUCCUT UUUUBUUBCB B3TGGCTGCCT CCCCGGGUTT~ TCTGCTGCT7 GCTGCTTCTT TCCCUTCTCC cYTCTTI7ccC UTCTCCTTTT TGCCTC1T~r UUTTCCTU1T UTT-rcTUGCC TUCTTUUTUU CUUCT-FTUC UYITCCTCTC TCTI7CTC11'U UUTCTCCUCT TCTCUTCCTU CCTMTCCTU 265 TCTCTGTCGC GCCG17CCTC CTCGGGCGTC GGTGCTCCCC CGGCGGGCCG TGTGGTGGGC TCTTCTGTGG CCTCCCTTGT GCTGGGTGCG CTGGCTCTTG CCCTGTCCTT ATT[CAGGCA TTATAAGGAA

GCTGGTTGCC

CCTGTGGGGC

GCCTCCCCGC

CTTCGCCTCG

TGAAATTATA

CTCCTGCCCT GTGCTG1TTTG CCTCGGGTGG TGCGGGTCCC TGGGCCTGTC TGGTGGGGTG TGGGGCCGCT GGGTTGGGGG TGTTGGTGTC TCTGTGGGCG TGTGCTGGGT CTTGGGGCTT CCCCCTTCTG GGCCGGTGGC CTGGCTCCTT GTGGGCGCTT TGGCTGCTGG GCTGC CATATGTATG GGAATACTGT GGCCGGGCAT TGTGGCTAAC CCTTGTAATC CTAGCACT

GAGAGGCTGA

AGTCTCTACC

AGGCTGAGGT

CTCCAGTCTT

GAAATTATAA

CCTACCTGCC

GGCCTCTCTG

TCTGGAATAA

TGTCAATATT

CCAGAGAGCT

AAACCTGGCT

AGTGGGCAGA TCACTTGAGC TTCAGAGTTC GAGACCAGCA TGGACAACAT GGTGAAACCC AAAAACACAA AAATATTAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCGA GCTACTCAGG GGGAGGATCG CTfGAGCCTG GGAGGCAGAA GTTGCAATGA GCAGAGATCG TGCCACTCCG GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA TAAATGAAAT GAAATTACCA CTTTTCATG TAAGAAGTGA TCATTTCCAT TATAAGGGAA GGAITrTAAT ATTCCACCAA AGCTTACCTA GTGCTAAAGG ATGAGGTGTT AGTAAGACCA ACATCTCAGA TGCCAATAGC CTTCCTTCCT TTCCCTTrCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TGGCATCATC TAATATCACT GGCCTTCTGG AACCTGGGCA TTTJTCCAGTG TGTTCCATAC CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATTAA CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TGGCCAAATA CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC TGCCACCTTG GACTTGGGAC CAGAAAGAGG TGGG17GGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA ACTGTACACA AGCTGGGGAC ACTCCCTTrrG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CCfrTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC CAGTGTGTTC ATAACTflGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCATTCCT GCTTTAAAAT CTCTCGGCCA CCTTTGATGA GGGGACTGGG CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGTTT GACTGTCC1r ACCCCGGGGA GOCAGTGCAG CCAGCTGCAA GGTGAGTTGC C CATATGTATG GGAATACTGT ATTTCAGGCA YJTATAAGGAA TGAAATTATA GGCCGGGCAT

TGTGGCTAAC

GAGACCAGCA

GGTGCATGCC

GTTGCAATGA

AAATAAATAA

TCATTFCCAT

ATGAGGTGTT

AAAACCTCAA

AACCTGGGCA

TGGAAAAGTG

GAAAGTGAGG

GCTGATGAAC

GATGTAACAG

CCTTGTAATC CTAGCACTTT GAGAGGCTGA AGTGGGCAGA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG TCACTITGAGC TTCAGAGTTC AAATATTAGC TGGGTGTGGT CTTGAGCCTG GGAGGCAGAA GCAGAGATCG TGCCACTCCG ATAAATAAAA TAAATGAAAT TATAAGGGAA GGAATTTAAT AGTAAGACCA ACATCTCAGA GTGACTAGTT CAGAGGCCTG TTTTCCAGTG TGTTCCATAC AGAGGATGGA CAGGGATTAA CCATGTGGCT TGGCCAAATA CTCCAGTCTT GGTGACAGAA TGAGACTCCA GAAATTATAA GAAATTACCA CTTITTTCATG CCTACCTGCC ATTCCACCAA AGCTTACCTA

TCTCAAAAAT

TAAGAAGTGA

GTGCTAAAGG

GGCCTCTCTG

TCTGGAATAA

TGTCAATATT

CCAGAGAGCT

AAACCTGGCT

TGCCACCTTG GACTTGGGAC CAGAAAGAGG CAAGATCAGG TCACCCACAG GCCCTGGCAG TGCCAATAGC CTTCCTTCCT TTCCCY[FCCA TGGCATCATC TAATATCACT GGCCTFCTGG CCCCCAGCTT CCTGGACTCC TGTCACAAGC CCCTGCTGAG GAAAAAATCT CCCAGATGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT TGGGTTGGGT GAAGAGGCAC CACACAGAGT TCACAGTCAT AAATTAGCTA ACTGTACACA AAAAAAGAGA CCTFTATGCA AAAACAACTC CAGTGTGTTC ATAACTTTGT AGCGAGTCGA GCT-TTAAAAT CTCTCGGCCA CCTTTGATGA CACAGGTCTC YJTCCTGGTTT GACTGTCCTT AGCTGGGGAC ACTCCC'TrG GAAACCAAAA AAAAAAAAAA TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCATTCCT GGGGACTGGG CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C-3' (FRAG. NO:J(SEQ. ID NO: 3016) ATCTCTCGGC CACCTTTGAT GAGGGGACTG GGCAGTTCTA GACAGTCCCG AAGTTCTCAA GGCACAGGTC TCTrCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGTGC AGCCAGCTGC AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA GTGACCTGCT TTGTAAAGCC ATAGAGATGG CCTGTCCTTG GAAATTTCTG TTCAAGACCA AATrCCACCA GTATGCAATG AATGGGGAAA AAGACATCAA

CAACAATGTG

CTCAGCAAGC

TCAAGCTGGA

TCCAAGAC

ATTATGACTC

AAGCTATCGA

GGTGGAAGCG

GCCACCAAGC

TCGATGCCCG

CAACAATGGC

GTGTGGAATG

CCAACGTGGA

CCCCCTGGTC

GTGGCCATGG

TGGCCAACAT

CACAGAGATC

ATGGGCCTGG

TGATCCATAG

GTACATGCAG

TCTGGGAGCA

GAGAAAGCCC

AGCAGAATGA

TGCAACCCCA

ACACTI1CACC

CCAAAAGTTT

ATTrGTCAAC

GTAACAAAGG

AGGCCTGGCG

CCTGTGCCAC CTCCAGTCCA GTGACACAGG ATGACCTI'CA GTATCACAAC GTCCCCGCAG CCCCTCGTGG AGACGGGAAA GAAGTCTCCA GAATCTCTGG T7GTCCTCCC CACGGCATGT GAGGATCAAA AACTGGGGCA GCGGGATGAC ATAAGGCCAA AGGGATTTTA ACTITGCAGGT CCAAATCTTG CCTGGGGTCC GACCAGAGGA CCCAGGGACA AGCCTACCCC TCCAGATGAG CTTCTACCTC CAATATTACG GCTCCTTFCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCTTC CAATGCCCCA CGCTGCATTG CAGCTGTTCC ACTGCCCGGG AAATGMrGA AACATCAGGT CGGCCATCAC CGTGTTCCCC CTCAGCTCAT CCGCTATGCT GGCTACCAGA ATrCACTCAG CTGTGCATCG ACCTGGGCTG CTGCAGGCCA ATGGCCGTGA CCCTGAGCTC AACATCCCAA ATACGAGTGG TTTCGGGAAC GCTGCTTGAG GTGGGCGGCC TGGAGTTCCC GGAGTCCGGG ACTTCTGTGA CGTCCAGCGC AAACGCACAA GCTGGCCTCG CTCTGGAAAG TMTCAGAAG CAGAATGTGA CCATCATGGA AATGAATACC GGTCCCGTGG GGGCTGCCCG TCACCCCCGT GTTTCACCAG GAGATGCTGA

GGAGGATCCA

ACACATCTGC

CAGCGGAGTG

TGCCAGATGG

GAAGCCCAAG

TUCGAAATCC

TGGAGCTAAA

AGGGTGCCCC

GTGGTCCAAC

AGACACGTGC

ATGGCAAGCA

CAGCATCAGA

TACGGCCGCT

CACCTGACCT

GTGGTACGCC

TTCAATGGCT

CTGCAGGTCT

GTTACTCCAC

CGACTTCCGG

GGGGACCCTG

TCGATGTGGT

TGTGCTrGAG

CTGCCTGCAG

GGTACATGGG

GGGCAGGAGA

AACATTGCTG

CCT-rCATGAA

CCCTCCCATG

TACTACTATC

TACAACATCC TGGAGGAAGT ACCAGGCTGT CGTT1GAGATC CCACCACTCG GCTGCAGAAT OCAGACTOGA TTI'GGCTGGT ACTACGTCCT GTCCCCTFrTC AGGTAGAGGC CTGGAAAACC CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG AGATTCCATT 266 GAAAGTCTTG GTCAA GTCACCATCC TCT17( GCTGTGCCTT CAACC GCTGTTGGTG GTGAC CTCTTCATGC TGAAA CTCGGY[rCTG CGCCT' GATGGGAGAA GGGG.

GCAGCCTGTG AGACC TGACCTGGGA CCCGC CAGCATGCAT GCCAA AGCCGTGCCA CCATC ACCTTGGGGT TTGCC CACACCCCAC CAGAC CTGCCCCCCT GCTCA4 TGCTCCAAAA GCTGG CTCAGAGTAC AGCAA CTGCGGGTGT CTGCT CCTCCCGGGA TCACA CCAGGGTCCC CTGCA TGCTTTGTGC GGAAT CTGGCACAGG CATCG GCGGGGAGGC CGCA1 ATGCTGGAGA TGGCC CCAAGGTCTA TGTTC GCCAGGCCAC CTCTA GTGGCTGCCA AGCTG GCTATCACGA AGATA CAGCAGCCTG GAGAT GATGGAGCCA GCTCT CTCAAGTCTT AT'ITC( GGATTGATCG GAGCC GGCCTGGCGA GTGGG TATCGCACCA CTGTG CCAGTCTGTT CCCCA CATTTTACTT TAATC GCAACTTGAA GAGCG GTGCGGCAAG CAGGC GCGCCAGAAC ACAGC AGAACTGGGA GGTGC CCCAAGACGC TGCCT GCCCCTGAGC AGCTG GCTCCCAGGC CCACG.

TAGGGAGAGC GAGC1 CAGTGGGGGA AGCTC GCAACCACAT CAAGT CCCTGGCCGA GGAGA GGCTCTGTGC GGGGG GAAACGGTCG C11TCG GCCCCCCGAG CTGGT CGCTGGTACG CCCTC' CCU-CAGTGG CTGGTj CCTGGAGGAT GTGGC GCAGTGGAAA TCAAC CCGCCACGGC CTCTT GGCCTGGATC GTGCC CTGTCCCCGO CCYI7CC GGAAGAAGAC C'FITA GAAGCGAGTG AAGGC GGGAGACTCT TCCGG AACACGAGAC GCTGG CT17TGCAGCT GCCCT( TATAAGATCC GC'fTCj AGTCCAGTAA CACAG GGCATACCCC CACT-r( CTGCTGCAGC TGGGC CCTTCCAGGC CGCCT( CCCCAAACGG AGCTG AGCTG TGCTCTTTGC CTGTATGCTG ATGCGCAAGA CAATGGCGTC CCGAGTCAGA 3CGAC AGAGACAGGA AAATCAGAGG CGCTGGCCTG GGACCTGGGG GCCTTATTCA CCAAG GTTGTCTGCA TGGATAAGTA CAGGCTGAGC TGCCTGGAGG AGGAACGGCT CAGTA CGTTFGGCAA TGGAGACTGC CCTGGCAATG GAGAGAAACT GAAGAAATCG GAGCT CAACAACAAA TTCAGGTACG CTGTGTTTGG CCTCGGCTCC AGCATGTACC ~TGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGCCTCTC AGCTCACCCC kTGAGC TCAGTGGGCA GGAGGACGCC TTFCCGCAGCT GGGCCGTGCA AACCTTCAAG ITTGA TGTCCGAGGC AAACAGCACA TTCAGATCCC CAAGCTCTAC ACCTCCAATG ACCAC TACAGGCTCG TGCAGGACTC ACAGCCTTTG GACCTCAGCA AAGCCCTCAG GAACG TGTTCACCAT GAGGCTCAAA TCTCGGCAGA ATCTACAAAG TCCGACATCC CTGGT GGAACTCTCC TGTGAGGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC CAGGC AACCAGCCGG CCCTGGTCCA AGGCATCCTG GAGCGAGTGG TGGATGGCCC AGTGC GCCTGGAGGA CCTGGATGAG AGTGGCAGCT ACTGGGTCAG TGACAAGAGG

CTCAG

CCCAG

GTGGA

GGC1T

CGCCC

CCACG

GCCAG

TGCCC

*GACCT

CAGAA

AGGAC

CCAGGCCCTC

GTGGCCACAG

AGTTCACCAA

CCTGCTT-rCC

ACGGAGATCC

GTGTCTGCAG

CGCCTTCCAC

U7CCGCAGT-f

TGGTGTTTGG

ACCTACTCCC CGGACATCAC AAGAGCCTGA GAGACAGAGG CAGCCCCACA TTCCTGGAGG CAGCTCCCCA TCTGAAGCC ACCTGACTGT GGCCGTGGTC CACATGGCTC AACAGCCTGA CTCCCCGAGG ATCCCTCCCA TCTGGCAGCA ACGGCTCCAT GTGCCGCCGC CCAGATGAGG GGGGGTGCTG CATGCGGTGC ACACAGCCTA ATCCTGCGGC AGCAGCTGGC CAGCGAGGTG

CACACCCCCA

CTGGAGGCCC

TGCTAGAGGA

CAGGTTCTAC

ACCTACCACA

AGCCCCAAGA

TCCTTGCATC

GACTCCCAGC

ACCACATCTA

T7CCCGCCTG

CTCCGTGTGC

CCCACACCCT

TCAGCTCAAG

GACAGGGTGG

CTGCCGGCAC

GGAAAGTGAT

CTCCTAACAA

AGACAAAATC

AAGTGACCAC

TGTATrrTAAA

GGAGATATTT

ACCCAGCTGC

TGTGCCAGCC

GTTCCCGTCC

TCCATCAGCT

CCGGAGATGG

CCCAGTGCCC

CTCATCGGGC

ACAAGGGAGT

CCAGGAGGAG

CCTGGCAAGC

TCCACAAGGA

GAAGCAGCTG

AGCCAGAAGC

CGGTGCAGCC

AGAACTTAAG

ATCCCCCAGC

GTAGCACCCT

17AAATGCCA

CAGGAGGTGC

AAACTAACAC

ACATGAATTG

TGTIT GCGGGGATGT GCGCATGGCC CGGGACGTGG AAATT GAATGAGGAG CAGGTCGAGG ACTATTTCTT TC'rrC GGTGCTGTAT TTCCYJ7ACGA GGCGAAGAAG 'GTCAG CGCTCTGAGG GCCTACAGGA GGGGTTrAAAG GCATT ATCTGAGGTC ACAGGGCCTG GGGAGATGGA 2TCAA CGTTGCTCCC CATCAAGCCC T17ACTTGAC TCCTC TCTCAAACTG GGGCCTCCCT GGTCCCTTGG TGAAA GATGGAACTT GCTGCTGAGT GCACCACTTC TAITTT AACTGCC'rrG TGTACAG'FrA MTATGCCTC TGGCC ACTTGGGTCT TCCCTGTATG ATTCCTTGAT GAATrCCCAC TCTGCTGCCT GCTCCAGCAG ACGGACGCAC AGTAACATGG TGGCC CAGGAGCCTG ~CCCAG CCACCCCGGC CCCCC GAGCTCCCCG GGAGC ATCACCTATG

GGGCT

CTGAG

AACAG

'GGTGT

iCAGGT

ATGCC

CTTCC

GACCC

ACGTG

CYTG

CCGGC

~CATG

CCCTGGTATT

TCAGGCCCGG

CGGCTTCAAG

TCGGGGCTAA

GTTCGATGCC

ACCAACCGGG

GAATCTGGAA

AGCCAACGTG

CTGCCCCTGC

AGGTGCCCCT

AGTGTCCAAC

AGCACTGAGA

GGCCACCCTG CGGCCTGGGG CTGGGGCTGG GCCTTGGGCT CCCTGAGCCC AGCCGGGCCC CAGCATCCCT ACTCCCACCA CTAACCCAGC CCCCAGAGGG GCCCAAGTTC CCTCGTGTGA ACACCCTCAG CGCCCAGGCG CAGCAGGATG GGCCCTGCAC TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GACTrCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT GCAGGCCTGG CGCAACGCTC CCCGCTGCGT GGGCCGGATC CGGGACTGCA GGTCTGCACA GGAAATGTTC ACCTACATCT GCAACCTTCG CTCGGCCATC ACAGTGTTCC CGCAGCGCTG CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCTTCCTTCT GGAGCACCCC ACGCTGGAGT GGTTTGCAGC CCTGGOCCTG ATGCTGCTGG AAATTGGGGG CCTGGAGTTC CCCGCAGCCC TCGGCACGAG GAACCTGTGT GACCCTCACC GCTACAACAT TGTCT GCATGGACCT GGATACCCGG ACCACCTCGT CCCTGTGGAA AGACAAGGCA GTGGC CGTGCTGCAC AGTTACCAGC TAGCCAAAGT CACCATCGTG GACCACCACG rCATG AAGCACCTGG AGAATGAGCA GAAGGCCAGG CCCCA TCTCGGGCAG CCTCACTCCT GTTICCATC X3CTA CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC AGAA GTGGCCAACG CCGTGAAGAT CTCCGCCTCG GACAA TCCTGTATGG CTCCGAGACC GGCCGGGCCC

GGGGGCTGCC

AGGAGATG

CAAGGGCACC

CTCATGGGCA

AGAGCTACGC

GTATGACGTG

CCCCCGGAGA

GGCCGGAACA

TTFGGCGGCGG

CTGCAGACTG

CAACTATTTC

GGCATCACCA

CGGTGATGGC

ACAGCAGCTG

GTGTCCCTCG

ATGGAGAGAG

GCACAAGAGT

AAGAGGAAGG

AAGGC

TGCTG

3ATGG

AACAG

ACAGT

TGCG

CAGGG

GTGAG

TMGATCCC

GTGGTAACCA

AGATGTCCGG

CATCTCCTGC

CGGGTCCTGT

GCACAT-'TGG

CCCCTACAAC

TCAGACCCAC

GTATGGATGA

GAATGGGGAT

AGCTCCCCTC

TGGTGTCCTC

GCAGGGGCCC TGGGCACCCT CAGGTTCTGT GTGTTCGGGC TCGGCTCCCG CCY-ITGCTCG TGCCGTGGAC ACACGGCTGG AGGAACTGGG CGGGGAGCGG CGACGAGCTG TGCGGCCAGG AGGAGGCCTTr CCGAGGCTGG GCCCAGGCTG ACCTTCTGTG TGGGAGAGGA TGCCAAGGCC GCCGCCCGAG ACATCTTCAG GAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA GYTGCTGCCA 267 GGTCTGATCC ACGTGCACAG GCGGAAGATG TTCCAGGCTA CAATCCGCTC AGTGGAAAAC CTGCAAAGCA

GCAAGTCCAC

GGGGGACCAC

GACCCGCCGG

CCGGCTGGGT

CACCTCCCCA

GAGCTGGAGG

TGGAGGTGCT

CCAGCCCCGG

GTGCTGGCAT

AGCTCAAGCC

CAGCTTGCCC

CTGCATGACA

AACTTGACCA

GAGGGCCACC

ATAGGTGTCT

CGCCCACTGA

GCGGGACCCC

CCCAGCCCTC

CCCTCAGCCA

GGAGCAGTTC

TACTACTCAG

ACAGGACTCA

CGGAGACCCT

ATCCTGGTGC GCCTGGACAC CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GCCCGCCCAA CCGGCCCGGC CTTGTGGAGG CGCTGCTGAG CCGCGTGGAG GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTrCT TCCTGGACAT AGCTCT-rGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG GGAACAGCAG GGATCCCCGA CGCTACGAGG AGTGGAAGTG GTTCCGCTGC CCCACGCTGC CCGTCGGTGG CGCTGCCTGC CCCACTGCTC CTCACCCAGC TGCCTCTGCT TCAGCTCGGC ACCCAGCACC CACCCAGGAG AGATCCACCT CACTGTAGCT GGATGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAAGCC GTGCCCTGCT TCATCCGGGG GGCTCCCTCC TTCCGGCTGC CACCCGATCC TGCATCCTGG TGGGTCCAGG CACTGGCATT GCCCCCTTCC GGGGATTCTG GCAGGAGCGG T[GAGAGCAA AGGGCTGCAG CCCACTCCCA TGACTTTGGT TCTCTACCGC GACGAGGTGC AGAACGCCCA GCAGCGCGGG CGCCTTCTCC CGGGAACCTG ACAACCCCAA GACCTACGTG CAGGACATCC

GAGGTGCACC

ACGTCCTGCA

CATCGGCGTG

GTGACAAGCC

CGTTCGACCC

GAGCGGCTGC

CTCACATCTG

CTCTCTAGGC

AGGGCCTACT

GCGTGCTGTG CCTCGAGCGG GGCCACATGT TTGTCTGCGG GACCGTGCAG CGCATCCTGG CGACGGAGGG CGACATGGAG CTGCGGGATC AGCAACGCTA GCATACGCAC CCAGAGCTTT TCCCGGCTCA GACACCAACA CCGACTCAGG TCCGCCCGAC TCCAGAGGCT GCAAGGAT7C CTGTTGCCTC GGGCCTGGGT GCCACCCGCT TCCTGTCT CCACGAAGAC ATYICGGGC TCCTTGCAGG AGCGTCAGTT GCCCCTGAGA GCCGCCTGGC CAGGATCAGC CCCGCTCCTC AGCATTATTC CTCCAGGAAG CCGCCTTAAT CTGGAAGGCC TAGTCCGAAT GTTAGATTCC GTTCGGCTGC CGATGCTCCC GTGTTTGGCC GAGTCCTCAC TGAGGACGGA GCTGGCTGCG CGATGTTACC ATGGCAACCA CTGGACGAGG CCGGCGACGT TCACGCTGCG CACCCAGGAG GCGGGGCGCA GTGCCCTGGG TTCCC17CC AGTTCCGGGA CCCTCTTGAG GTGGTGCCTT GAGCAAAACG CCTCYTMCC CCTCCCAGCA GCGGTACCCC TCTTGCCTCT CTCAGGAGTA TCTTACCTGT AAAGTCTAAT CTCTAAATCA AGTATTrATT ATTGAAGATT TACCATAAGG GACTGTGCCA GATGTTAGGA GAACTACTAA AGTGCCTACC CCAGCTC-3' (FRAG. NO:1897) (SEQ. ID NO: 3017) GGAATACTGT ATTTCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT CCTITGTAATC CTAGCACT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC TTCAGAGUTC TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA AAATATTAGC TGGGTGTGGT TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG CTTGAGCCTG GGAGGCAGAA GCAGAGATCG TGCCACTCCG CTCCAGTC'rr GGTGACAGAA TGAGACTCCA TCTCAAAAAT ATAAATAAAA TAAATGAAAT GAAATTATAA GAAATTACCA CTT7TTCATG TAAGAAGTGA TATAAGGGAA GGAATTTAAT CCTACCTGCC AY7CCACCAA AGCTTACCTA GTGCTAAAGG AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC C'FrCCTTCCT TTCCCYJ7CCA GTGACTAGTTr CAGAGGCCTG TCTGGAATAA TGGCATCATC TAATATCACT GGCCTTCTGG T-rTTCCAGTG TGTTCCATAC TGTCAATATT CCCCCAGCTT CCTGGACTCC TGTCACAAGC AGAGGATGGA CAGGGATTAA CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT CCATGTGGCT TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCT-fAG CAGCCACCCT

TGTGGCTAAC

GAGACCAGGA

GGTGCATGCC

GTTrGCAATGA

AAATAAATAA

TCATTfCCAT

ATGAGGTGTT

AAAACCTCAA

AACCTGGGCA

TGGAAAAGTG

GAAAGTGAGG

GCTGATGAAC

TGCCACCTTG GACTJ7GGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA ACTGTACACA AGCTGGGGAC ACTCCCYI'TG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CC'TrTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC CAGTGTGT7C ATAACT'rfGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCA'rrCCT GCTTTAAAAT CTCTCGGCCA CC1TTGATGA GGGGACTGGG CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGTrT GACTGTCCTT ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C-3' (FRAG. NO:_J(SEQ. ID NO: 2506) ATCTCTCGGC CACCnI7GAT GAGGGGACTG GGCAGTTCTA GACAGTCCCG AAGTJTCTCAA GGCACAGGTC TCTTCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGTGC AGCCAGCTGC AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA GTGACCTGCT TTGTAAAGCC ATAGAGATGG CCTGTCCTrG GAAATTTCTG TTCAAGACCA AATTCCACCA GTATGCAATG AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC CCTGTGCCAC CTCCAGTCCA GTGACACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC AGCAGAATGA GTCCCCGCAG CCCCTCGTGG AGACGGGAAA GAAGTCTCCA GAATCTCTGG TCAAGCTGGA TGCAACCCCA TTGTCCTCCC CACGGCATGT GAGGATCAAA AACTGGGGCA GCGGOATGAC MrCCAAGAC ACACTTCACC ATAAGGCCAA AGGGATTIA ACTTGCAGGT CCAAATCTTG CCTGGGGTCC ATTATGACTC CCAAAAGTTr GACCAGAGGA CCCAGGGACA AGCCTACCCC TCCAGATGAG CTFTCTACCTC AAGCTATCGA A'FrTGTCAAC CAATATTACG GCTCCT-rcAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAAGCG GTAACAAAGG AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCTTC

GCCACCAAGC

TCGATGCCCG

CAACAATGGC

GTGTGGAATG

CCAACGTGGA

CCCCCTGGTC

GTGGCCATGG

TGGCCAACAT

CACAGAGATC

ATGGGCCTGG

TGATCCATAG

AGGCCTGGCG CAATGCCCCA CGCTGCATTG CAGCTGT7rCC ACTGCCCGGG AAATGTTTGA AACATCAGGT CGGCCATCAC CGTGTTCCCC CTCAGCTCAT CCGCTATGCT GOCTACCAGA A17CACTCAG CTGTGCATCG ACCTGGGCTG CTGCAGGCCA ATGGCCGTGA CCCTGAGCTC AACATCCCAA ATACGAGTGG TTTCGGGAAC GCTGCTTGAG GTGGGCGGCC TGGAGTTCCC GGAGTCCGGG ACTTCTGTGA CGTCCAGCGC AAACGCACAA GCTGGCCTCG CTCTGGAAAG YITMCAGAAG CAGAATGTGA CCATCATGGA 268

GGAGGATCCA

ACACATCTGC

CAGCGGAGTG

TGCCAGATGG

GAAGCCCAAG

TfCGAAATCC

TGGAGCTAAA

AGGGTGCCCC

GTGGTCCAAC CTGCAGGTCT AGACACGTGC GTTACTCCAC ATGGCAAGCA CGACTTCCGG CAGCATCAGA GGGGACCCTG TACGGCCGCT TCGATGTGGT CACCTGACCT TGTGCTTGAG GTGGTACGCC CTGCCTGCAG 1TCAATGGCT GGTACATGGG TACAACATCC TGGAGGAAGT GGGCAGGAGA ACCAGOCTOT CGTTGAGATC AACATTrGCTG CCACCACTCG GCTGCAGAAT CCITCATGAA

GTACATGCAG

TCTGGGAGCA

AGGTAGAGGC

GAAAGTCT-rG

GTCACCATCC

GCTGTGCCTT

GCTGTTGGTG

CTCTTCATGC

CTCGGUrCTG

GATGGGAGAA

GCAGCCTGTG

TGACCTGGGA

CAGCATGCAT

AGCCGTGCCA

ACCTTGGGGT

CACACCCCAC

CTGCCCCCCT

TGCTCCAAAA

CTCAGAGTAC

CTGCGGGTGT

CCTCCCGGGA

CCAGGGTCCC

TGCT11TGTGC

CTGGCACAGG

GCGGGGAGGC

ATGCTGGAGA

CCAAGGTCTA

GCCAGGCCAC

GTGGCTGCCA

GCTATCACGA

CAGCAGCCTG

GATGGAGCCA

CTCAAGTCTT

GGATTGATCG

GGCCTGGCGA

TATCGCACCA

CCAGTCTGTT

AATGAATACC

TCACCCCCGT

CTGGAAAACC

GTCAAAGCTG

TCTT-rGCGAC

CAACCCCAAG

GTGACCAGTA

TGAAAGAGCT

GGTCCCGTGG

GTTTCACCAG

CATGTCTGGC

TGCTCTTTFGC

AGAGACAGGA

GTTGTCTGCA

CGT11TGGCAA GGGCTGCCCG GCAGACTGGA TTUGGCTGGT CCCTCCCATG GAGATGCTGA ACTACGTCCT GTCCCCTTTC TACTACTATC AGGACGAGAA GCGGAGACCC CTGTATGCTG ATGCGCAAGA AAATCAGAGG CGCTGGCCTG TGGATAAGTA CAGGCTGAGC TGGAGACTGC CCTGGCAATG CAACAACAAA TTCAGGTACG CTGTGTTTGG CGCCTGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGATGAGC TCAGTGGGCA GGAGGACGCC TrfCCGCAGCT

AGACGTTJTGA

CCCGCACCAC

GCCAAGAACG

CCATCCTGGT

TTGCCCAGGC

CAGACAGTGC

GCTCACTCAG

GCTGGCCCAG

AGCAAGTGGA

CTGCTGGCT-[

TCACACGCCC

CTGCACCACG

GGAATGCCAG

CATCGTGCCC

CGCATGACCT

TGGCCCAGAA

TGTTCAGGAC

TGTCCGAGGC

TACAGGCTCG

TGTTCACCAT

GGAACTCTCC

AACCAGCCGG

GCCTGGAGGA

CCAGGCCCTC

GTGGCCACAG

AGTTCACCAA

CCTGCTTf7CC

ACGGAGATCC

AAACAGCACA

TGCAGGACTC

GAGGCTCAAA

TGTGAGGATG

CCCTGGTCCA

CCTGGATGAG

ACCTACTCCC

AAGAGCCTGA

CAGCCCCACA

CAGCTCCCCA

ACCTGACTGT

TTCAGATCCC

ACAGCCTTTG

TCTCGGCAGA

GCCAAGGCCT

AGGCATCCTG

AGTGGCAGCT

CGGACATCAC

GAGACAGAGG

TTCCTGGAGG

TTCTGAAGCC

GGCCGTGGTC

AACAGCCTGA

AAGAGAAGAG AGATTCCATT CAATGGCGTC CCGAGTCAGA GGACCTGGGG GCC~rATTCA TGCCTGGAGG AGGAACGGCT GAGAGAAACT GAAGAAATCG CCTCGGCTCC AGCATGTACC GGGGCCTCTC AGCTCACCCC GGGCCGTGCA AACCTTCAAG CAAGCTCTAC ACCTCCAATG GACCTCAGCA AAGCCCTCAG ATCTACAAAG TCCGACATCC GAACTACCTG CCGGGGGAGC GAGCGAGTGG TGGATGGCCC ACTGGGTCAG TGACAAGAGG CACACCCCCA ACCCAGCTGC CTGGAGGCCC TGTGCCAGCC TGCTAGAGGA GTTCCCGTCC CAGGTlCTAC TCCATCAGCT ACCTACCACA CCGGAGATGG AGCCCCAAGA CCCAGTGCCC TCCTITGCATC CTCATCGGGC GACTCCCAGC ACAAGGGAGT ACCACATCTA CCAGGAGGAG T7CCCGCCTG CCTGGCAAGC CTCCGTGTGC TCCACAAGGA CCCACACCCT GAAGCAGCTG TCAGCTCAAG AGCCAGAAGC GACAGGGTGG CGGTGCAGCC CTGCCGGCAC AGAACT[AAG GTGTCTGCAG CACATGGCTC CGCCTTCCAC CTCCCCGAGG ATCCCTCCCA 'FrCCGCAGTf TCTGGCAGCA ACGGCTCCAT TGGTGTTTGG GTGCCGCCGC CCAGATGAGG GGGGGTGCTG CATGCGGTGC ACACAGCCTA ATCCTGCGGC AGCAGCTGGC CAGCGAGGTG CTCTATGTTr GCGGGGATGT GCGCATGGCC CGGGACGTGG AGCTGAAATT GAATGAGGAG CAGGTCGAGG ACTATTTCTT AGATATCTTC GGTGCTGTAT TTCCTTACGA GGCGAAGAAG GAGATGTCAG CGCTCTGAGG GCCTACAGGA GGGGTTAAAG GCTCTGCATT ATCTGAGGTC ATTTCCTCAA CGTITGCTCCC GAGCCTCCTC TCTCAAACTG GTGGGTGAAA GATGGAACTT CTGTGTATTT AACTGCCTTG CCCCATGGCC ACTTGGGTCT

ACAGGGCCTG

CATCAAGCCC

GGGCCTCCCT

GCTGCTGAGT

TGTACAG~rA

TCCCTGTATG

GGGAGATGGA

T'TTACTTGAC

GGTCCCTTGG

GCACCACT-C

TYI'ATGCCTC

ATTCCTTGAT

GGAAAGTGAT

CTCCTAACAA

AGACAAAATC

AAGTGACCAC

TGTATTTAAA

GGAGATATTT

ATCCCCCAGC

GTAGCACCCT

TITAAATGCCA

CAGGAGGTGC

AAACTAACAC

ACATGAATTG

CATTTTACTTTAATC-3' (FRAG. (SEQ. ID NO:2507) TCTGCTGCCT GCTCCAGCAG ACGGACGCAC AGTAACATGG GCAACTTGAA GAGCGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCTGGGG CTGGGGCTGG GCcTTGGGCT GTGCGGCAAG CCACCCCGGC CCCTGAGCCC AGCCGGGCCC CAGCATCCCT ACTCCCACCA GCGCCAGAAC GAGCTCCCCG CTAACCCAGC CCCCAGAGGG GCCCAAGTI7C CCTCGTGTGA AGAACTGGGA ATCACCTATG ACACCCTCAG CGCCCAGGCG CAGCAGGATG GGCCCTGCAC CCCAAGACGC CCCTGGTATT TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC TCAGGCCCGG GACTTCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC CGGCTTCAAG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT TAGGGAGAGC TCGGGGCTAA GCAGGCCTGG CGCAACGCTC CCCGCTGCGT GGGCCGGATC CAGTGGGGGA GTTCGATGCC CGGGACTGCA GGTCTGCACA GGAAATGTTC ACCTACATCT GCAACCACAT ACCAACCGGG GCAACCTTCG CTCGGCCATC ACAGTGTTCC CGCAGCGCTG CCCTGGCCGA GAATCTGGAA CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTGTGC AGCCAACGTG GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG GAAACGGTCG CTGCCCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCTTCCTTCT GCCCCCCGAG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GGTTTGCAGC CCTGGGCCTG CGCTGGTACG AGTGTCCAAC ATGCTGCTGG AAATTGGGGG CCTGGAGTFC CCCGCAGCCC CCTrCAGTGG AGCACTGAGA TCGGCACGAG GAACCTGTGT GACCCTCACC GCTACAACAT CCTbGAGGAT GCATGGACCT GGATACCCGG ACCACCTCGT CCCTGTGGAA AGACAAGGCA GCAGTGGAAA CGTGCTGCAC AGTTACCAGC TAGCCAAAGT CACCATCGTG GACCACCACG CCGCCACGGC AAGCACCTGG AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CTGCAGACTG GGCCTGGATC TCTCGGGCAG CCTCACTCCT GTTCCATC AGGAGATGGT CAACTATTTC CTGTCCCCGG CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC CAAGGGCACC GGCATCACCA GGAAGAAGAC GTGGCCAACG CCGTGAAGAT CTCCGCCTCG CTCATGGGCA CGGTGATGGC GAAGCGAGTG TCCTGTATGG CTCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT TITGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC GTGGTAACCA GCACATTTGG GAATGGGGAT CCCCCGGAGA ATOGAGAGAG CTTTGCAGCT AGATGTCCGG CCCCTACAAC AGCTCCCCTC GGCCGGAACA GCACAAGAGT TATAAGATCC CATCTCCTGC TCAGACCCAC TGGTGTCCTC TTGGCGGCGG AAGAGGAAGG AGTCCAGTAA GCAGGGGCCC TGGGCACCCT CAGGITCTGT GTGTTCGGGC TCGGCTCCCG GGCATACCCC 269

CAGGGCCCAG

ACAGCCCCCC

GGTGGGGAGC

TGCCTGGGCT

AGCTGCTGAG

CCACGAACAG

GAGCTGGTGT

AGCTGCAGGT

CAAGTATGCC

GGAGACTTCC

GGGGGGACCC

CTI'CGACGTG

CTGGTCCTTG

CCCTCCCGGC

CTGGTACATG

GTGGCTGTCT

TCAACGTGGC

CTC'T1CATG

GTGCCCCCCA

CCTI7CCGCTA CITfAAAGAA

AAGGCGACAA

TCCGGAAGGC

GCTGGTGCTG

GCCCTGATGG

GCTTCAACAG

CACAGACAGT

CACTI7CTGCG CC1TTUCTCG TGCCGTGGAC ACACGGCTGG AGGAACTGGG CGGAGCGG CTGCTGCAGC TGUCCAGUG CGACGAGCTG TGCGGCCAGG AGGAGGCCTF CCGAGGCTGG UCCCAUGCTG CCTrCCAGGC CGCCTGTGAG ACCTTCTGTG TGGGAGAGGA TGCCAAGGCC GCCGCCCGAG ACATCTTCAG CCCCAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA GTTGCTGCCA GGTCTGATCC ACGTGCACAG GCGGAAGATG TTrcCAGGCTA CAATCCGCTC AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC GCCTGGACAC CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGUGACCAC ATAGGTGTCT GCCCGCCCAA CCGGCCCGGC CTTGTGUAGG CUCTUCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT GCGGGACCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTrCT TCCTGGACAT CACCTCCCCA CCCAGCCCTC AGCTCTTGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG GGAACAGCAG GAGCTGGAGG CCCTCAGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG GTTCCGCTGC CCCACGCTGC TGGAGGTGCT GGAGCAGTTC CCGTCGGTGG CGCTGCCTGC CCCACTGCTC CTCACCCAGC TGCCTCTGCT CCAGCCCCGG TACTACTCAG TCAGCTCGGC ACCCAGCACC CACCCAGGAG AGATCCACCT CACTUTAUCT UTOCTGGCAT ACAGGACTCA GGATGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAAGCC AGCTCAAGCC CGGAGACCCT GTGCCCTGCT TCATCCGGU GGCTCCCTCC TTrcCGGCTGC CACCCGATCC CAGCTTGCCC TGCATCCTGG TGGGTCCAGG CACTGGCATT GCCCCCTJTCC GGGGATrCTG GCAGGAGCGG CTGCATGACA flGAGAGCAA AGGGCTGCAG CCCACTCCCA TGACTTTGGT GTTCGGCTGC CGATGCTCCC AACTTGACCA TCTCTACCGC GACGAGGTGC AGAACGCCCA GCAGCGCGGG GTGTTTGGCC GAGTCCTCAC CGCCTTrCTCC CGGGAACCTG ACAACCCCAA GACCTACGTG CAGGACATCC TGAGGACGGA GCTGGCTGCG GAGGTGCACC GCGTGCTGTG CCTCGAGCGG GGCCACATUT 1TGTCTGCGG CGATGTrACC ATGGCAACCA ACGTCCTGCA GACCGTGCAG CGCATCCTGG CGACGGAGG CGACATGGAG CTGGACUAGG CCGGCGACGT CATCGGCGTG CTGCGGGATC AGCAACGCTA CCACGAAGAC ATTTTCGGGC TCACGCTGCG CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAGCTTT TCCTrGCAGG AGCGTCAG1r GCGGGGCGCA GTGCCCTGGG CGTITCGACCC TCCCGGCTCA GACACCAACA GCCCCTGAGA GCCGCCTGGC TTTCCCTTCC AGT-FCCGGGA GAGCGGCTGC CCGACTCAGG TCCGCCCGAC CAGGATCAGC CCCGCTCCTC CCCTCTTGAG GTGGTGCCTI' CTCACATCTG TCCAGAGGCT GCAAGGATTC AGCArrATTC CTCCAGGAAG GAGCAAAACG CCTCITFrCC CTCTCTAGGC CTGTTGCCTC GGGCCTGGGT CCGCCT-rAAT CTGGAAGGCC CCTCCCAGCA GCGGTACCCC AGGGCCTACT GCCACCCGCT TCCTGTTTCT TAGTCCGAAT GTTAGATTCC TCTTGCCTCT CTCAGGAGTA TCTTACCTGT AAAGTCTAAT CTCTAAATCA AGTATrATT ATfGAAGATT TACCATAAGG GACTGTGCCA GATGTTAGGA GAACTACTAA AGTGCCTACC CCAUCTC (FRAG. (SEQ. ID NO:2508) 5'-CCCCGGGG-3' (FRAG. NO:1898) (SEQ. ID NO: 1911) 5'-GGGGCCGCTGGG-3' (FRAG. NO:1899) (SEQ. ID NO:1912) 5'-GGGGGTGTGG-3' (FRAG. NO:1900) (SEQ. ID NO: 1913) 5'-CTGCCTCCCCUGUT-3 (FRAG. NO:1442)(SEQ. ID NO:1451) 5'-TfCTGCTGCTTGCTG-3' (FRAG. NO:1443)(SEQ. ID NO:1452) 5'-CTTCTTTCCCGTCTCC-3' (FRAG. NO:1444)(SEQ. ID NO:1453) 5'-CTfCT1'TCCCGTCTCC-3' (FRAG. NO:1445)(SEQ. ID NO:1454) 5'-TI=GCCTCTTTG-3- (FRAG. NO:1446)(SEQ. ID NO:1455) 5'-GTTCCTGTTGTTTCT-3 (FRAG. NO:1447)(SEQ. ID NO:1456) 5'-GGCCTGCTTGGTGGCG-3 (FRAG. NO:1448)(SEQ. ID NO:1457) 5'-GCTUGTGCGTTTrCC-3- (FRAG. NO:1449)(SEQ. ID NO:1458) 5'-TCTCTCTTCTCTTGGGTCTCCGCTTCTCGTCCTGCC-3 (FRAG. NO:1450)(SEQ. ID NO:1459) 5'-ITflCCTGTCTCTGTCGC-3' (FRAG. NO:1 451 )(SEQ. ID NO:1460) 5'-GCCU'FfCCTCCTCC-3 (FRAG. NO: 1452)(SEQ. ID NO:1461) 5'-GGCGTCCTCCTGCCC-3' (FRAU. NO:1453)(SEQ. ID NO:1462) 5'-TGTGCTGTTTGCCTCGG-3' (FRAU. NO: I454)(SEQ. ID NO: 1463) 5'-GTGGTGCGGGTCCC-3' (FRAU. NO: I 455)(SEQ. ID NO: 1464) 5'-GGTGCTCCCCCGGC-3' (FRAU. NO: 1456)(SEQ. ID NO: 1465) 5'-GGGCCGGCTGGTTUCCTGGGC-3- (FRAU. NO:1I457)(SEQ. ID NO: 1466) 5'-CTGTCTGGTGGGGTGTGGGGCC-3' (FRAU. NO:1I458)(SEQ. ID NO: 1467) 5'-GCTGGGTTGGGGGTGTGGTG-3 (FRAU. NO: 1459)(SEQ. ID NO: 1468) 5'-GGCTCTTCTGTGGCC-3' (FRAG. NO:1I460)(SEQ. ID NO: 1469) 5'-TGTGGUCTGT'TGGTG-3' (FRAG. NO: 146 1)(SEQ. ID NO: 1470) 5'-TCTCTGTGGGCGTGTG-3' (FRAG. NO: 1462)(SEQ. ID NO: 147 1) 5'-CTGGGTC'FrGGGGCTTFC-3 (FRAG. NO: 1463)(SEQ. ID NO: 1472) 5'-CTCCCTFGTGCTGGG-3 (FRAU. NO: 1464)(SEQ. ID NO: 1473) 5'-TGCGUCCTCCCCGC-3 (FRAU. NO:1I465)(SEQ. ID NO: 1474) 5'-CCCCCTCTGGUCC-3 (FRAU. NO: I 466)(SEQ. ID NO: 1475) 5-GGTGGCCTGUCTCCTfUTGG-3 (FRAU. NO: 1467)(SEQ. ID NO: 1476) 5'-UCUCTTCTGUCTCTTG-3* (FRAU. NO:1I468)(SEQ. ID NO: 1477) 5'-CCCTGTCCT-FCT-rCGCCTCGT-3 (FRAU. NO: 1469)(SEQ. ID NO: 1478) 5'-GGCTUCTGGGCTUC-3' (FRAU. NO: I 470)(SEQ. ID NO: 1479) 5'-CTCCCCBUTTTGBTCCTCBCBTUCCGTGGGGBGGBCBBTGG-3(FRAG. NO:1901) (SEQ. ID NO: 1914) NF-kB Nucleic Acids and Antisense Oligonucleotide Fragments 5'-CUUCCCTTCT CACTGUAUUC ACCGUUCAUT CCTCCATGUU AGGUTTGUUC TTUUCCUUUU CTGCCCUUTG CCTCCTCTTU UCTUUTCCCT CUTTGTCCTT UUGCCCCGC TCCCUCTUCT CUUCCTCCUT UTTC1TT17UC 270 CTCT!'GCTCC GCCTGCTGTC TTGTCCCGTC CCCTCCTCGC T!'GCGTTTCC CTCTTCCT!'G TCT!'CCAGGC CT!'CCTCCGC T!'CCGCTGCT GGGGCCCGCG CCGGGGGGGC GCTCGGCTCC GCGGCTTCCT CCCCGGCTGG GGGGTCCTGG TCTCCGGGGC CTGCGGCTCG CGGGCTCGGG GCTGCGTGCG CCGCGCGCGG CGTCCGCGGT GGGTGGCGCT GTCCCGCCGT GGTGTGTCTC CGTTCTCGTC CTGCGCCGTC CTGGTCTGCC CGTGGGGTCC TGGGCGTGGT GGGGGGCGTC TGGTGCCTCG TCTGCCCCGT GGGGCTTCGG GCTCGGGGCT GT!'CGTCCCC CCTGCCGCTC TGTGGCCTCC GGGGCTCCTC GTT!TrCGCTG CTTCGGGTGT CCTTfCTCGGC GTGTGGCCCC GGGTCCCGGC CCTGCTGGGC TGGGCGGGGT CGCTGCCCTG GGCTTCTGGC CCGTCTGGTT GTCTGTCGGT GCTTGTCTCG GGTT!'CTGGC CTCTGTGCTG GGCGCTTCTC TGCCTCCTGC TCCGCCCTCC TGGTGGCTCG GCTGGGGGTG CCCGTGCGGG GGTGGGTGTG GGGTGTTTTC GGGGTCCTCC CCT!'CCC-3' (FRAG. NO:1902) (SEQ.

ID NO:1915) 5'-GGGCGGGGTCGC-3 (FRAG. NO:1903) (SEQ. ID NO:1916) 5'-GCGCCGTCC-3 (FRAG. NO:1904) (SEQ. ID NO:1917) 5'-GGGCGTGGTGG-3 (FRAG. NO:1905) (SEQ. ID NO:1918) 5'-GTTGGGCT-FGGCCGGGG-3 (FRAG. NO: 147 1)(SEQ. ID NO: 1480) 5'-CTGCCCGGTGCCTCC-3' (FRAG. NO: 1472)(SEQ. ID NO: 148 1) 5'-TC-FlGGCTGGTCCCTCGT-3 (FRAG. NO:!I 473)(SEQ. ID NO: 1482) 5'-TGTCCTTGGGCCCC-3' (FRAG. NO:! 474)(SEQ. ID NO: 1483) 5'-GCTCCCGCTGCTCGGCCTCCGT-3' (FRAG. NO: 1475)(SEQ. ID NO: 1484) 5'-GTTCT!'TGGCCTCTTGCTCC-3' (FRAG. NO: 1476)(SEQ. ID NO: 1485) 5'-GCCTGCTGTCTTGTCC-3' (FRAG. NO:1I477)(SEQ. ID NO: 1486) 5'-CGTCCCCTCCTCGCTTGCGTUTC-3 (FRAG. NO:! 478)(SEQ. ID NO: 1487) 5'-CCTCTCCTTGTCTCCA-3' (FRAG. NO: 1479)(SEQ. ID NO: 1488) 5'-GGCCUTCCTCCGCTTCCGCTGC-3 (FRAG. NO: 1480)(SEQ. ID NO: 1489) 5'-TGGGGCCCGCGCCGG-3' (FRAG. NO: 148 1)(SEQ. ID NO: 1490) 5'-GGGGGCGCTCGGCTCCGCGGCTTCCTCCCCGG-3 (FRAG. NO:1I482)(SEQ. ID NO: 149 1) 5'-CTGGGGGGTCCTGG-3 (FRAG. NO: 1483)(SEQ. ID NO: 1492) 5'-TCTCCGGGGCCTGCGGCTCGC-3' (FRAG. NO: 1484)(SEQ. ID NO: 1493) 5'-GGGCTCGGGGCTGCGTGCGCC-3- (FRAG. NO: 1485)(SEQ. ID NOA 494) 5'-GCGCGCGGCGTCCGCGGTG-3- (FRAG. NO 1486)(SEQ. ID NO: 1495) 5'-GGTGGCGCTGTCCCGCC-3 (FRAG. NO: I487)(SEQ. ID NO: 1496) 5'-GTGGTGTGTCTCCGTTCTCGTCCTGCGCCGTC-3- (FRAG. NO:1I488)(SEQ. ID NO: 1497) 5'-CTGGTCTGCCCGTGG-3'(FRAG. NO: 1489)(SEQ. ID NO: 1498) 5'-GGTCCTGGGCGTGGTGG-3' (FRAG. NO:I1490)(SEQ. ID NO: 1499) 5'-GGGGCGTCTGGTGC-3 (FRAG. NO: 149 1 (S EQ. ID NO: 1500) 5'-CTCGTCTGCCCCGTG-3 (FRAG. NO:1I492)(SEQ. ID NO: 150 1) 5'-GGGCTTCGGGCTCGG-3 (FRAG. NO: 1 493 )(SEQ. ID NO: 1502) 5'-GGCTGTTCGTCCCCCCTGCCGCTCTGTGGCCTCC-3 (FRAG. NO: 1494)(SEQ. ID NO: 1503) 5'-GGGGCTCCTCGTTTTC-3'(FRAG. NO: 1495)(SEQ. ID NO: 1504) 5'-GCTGCTTCGGGTGTCCTTCTC-3' (FRAG. NO:!I 496)(SEQ. ID NO: 1505) 5'-GGCGTGTGGCCCCGG-3'(FRAG. NO: 1497)(SEQ. I D NO: 1506) 5'-GTCCCGGCCCTGCTGGGCTGGGCGGGGTC-3' (FRAG. NO: I498)(SEQ. ID NO: 1507) 5'-GCTGCCCTGGGCTTCTGGCCCGTCT-3- (FRAG. NO: 1499)(SEQ. ID NO: 1508) 5'-GGT-rGTCTGTCGGT-3' (FRAG. NO: I500)(SEQ. ID NO: 1509) 5'-GCTTGTCTCGGGTTTCTGG-3' (FRAG. NO: 1 501 )(SEQ. ID NO: 15 5'-CCTCTGTGCTGGGC-3 (FRAG. NO:1I502)(SEQ. ID NO: 151 1) 5'-GCTTCTCTGCCTCCTGCTCC-31 (FRAG. NO:1I503)(SEQ. ID NO: 1512) 5'-GCCCTCCTGGTGGCTC-3' (FRAG. NO:1I504)(SEQ. ID NO: 1513) 5'-GGCTGGGGGTGCCCGTGCG-3' (FRAG. NO:1I505)(SEQ. ID NO: 1514) 5'-GGGGTGGGTGTGGGGTGTh3- (FRAG. NO- I506)(SEQ. ID NO: 5 5,-T-rCGGGGTCCTCCCCT-rCCC-3' (FRAG. NO: I507)(SEQ. ID NO: 15 16) 5'-CGGCCCTTCTCACTGGAGGCACCGGGCAGTCCTCCATGGGAGG-3' (FRAG.NO:1906)(SEQ.ID NO:1919) Human Major Basic Protein Nucleic Acids and Antisense Oligonucleotide Fragments TCA TCT TGG CT!' TAT CCTCT CCC CT!' GT! CCT CCC CTCT CCT GCT CTG GRG TCT CCT C T!'C CCT CCC TCC CCT 6CC GTG TTG TCT GTG GGT GTC GT!' TCG CTC TTG T!'G CCC TGG GCC CT!' CCC TGC TGG GGG GGA GTT TCA TCT TGG GT-r TCB TCT TGG CT!' TBT CCTCT CCC CT!' GT!' CCT CCC CTCT CCT GCT CTG GRG TCT CCT C T!'C CCT CCC TCC CCT 6CC GTG TI'G TCT GTG GGT GTC GTT! TCG CTC TG TTG CCC TGG 6CC CT!' CCC TGC TGGG666 GB GT!'TCB TCT TGG-3' (FRAG. ID:1907) (SEQ. ID NO:1920) GGA (FRAG. ID:1908) (SEQ. ID NO:1921) 5'-G CCC TGG 6CC C-3' (FRAG. ID:1909) (SEQ. ID N 0:1922) TCA TCT TGG CUT TAT CC-3' (FRAG. NO:1508) (SEQ. ID NO:1517) CCC CT!' GT CCT CCC C-3' (FRAG. NO:1509)(SEQ. ID NO:1518) CCT OCT CTG GRG TCT CCT C-3' (FRAG. NO:1510)(SEQ. ID NO:1519) CCT CCC TCC CCT GCC-3' (FRAG. NO:1 151 1)(S EQ. ID NO:1 520) 5'-GTG UTG TCT GTG GOT GTC C-3- (FRAG. NO:1 512)(SEQ. ID NO: 1521) TCG CTC TTG TTG CCC-3'(FRAG. NO: 1 51 3)(SEQ. ID NO: 1522) 271 0CC CU CCC TGC TGG-3' (FRAG. NO: 1514')(SEQ. ID NO:1523) GGA OTT TCA TCT TGG-3' (FRAG. NO: I515)(SEQ. ID NO: 1524) TCA TCT TGO CUT TAT CCTCT CCC CTT OTT CCT CCC CTCT CCT GCT CTG ORG TCT CCT C UTC CCT CCC TCC CCT GCC GTG HTG TCT OTO GGT GTC OTT TCG CTC TrG HTG CCC TGG GCC CUT CCC TOC TOG GG GOA GTT TCA TCT TGG-3' (FRAG. ID:1910) (SEQ. ID NO:1923) TCB TCT TOG CUT TBT CCTCT CCC CUT OTT CCT CCC CTCT CCT GCT CTG ORG TCT CCT C UTC CCT CCC TCC CCT 0CC OTO TTG TCT GTG GOT GTC OTT TCO CTC TTFG HTG CCC TGG GCC CU- CCC TGC TGG GG GGBGTT TCB TCT TGG-3' (FRAG. ID:191 1) (SEQ. ID NO:1924) Human Eosinophil Major Basic Protein Nucleic Acids and Antisense Oligonucleotide Fragments TCB TCT TOG CUT-3' (FRAG. NO:1516)(SEQ. ID NO:1525) 5'-000 GBOTT TCB TCT TGCTT-3' (FRAG. NO: 151 7)(SEQ. ID NO: 1526) GOB OTT TCB TCT TOO CT-3' (FRAG. NO: 1 51 8)(SEQ. ID NO: 1527) 5'-000 GOB OTT TCB TCT TOO C-3- (FRAG. NO:1I519)(SEQ. ID NO: 1528) 5'-GOG GOB OTT TCB TCT TGG-3' (FRAG. NO: 1 520)(SEQ. ID NO: 1529) 0GB GTT TCB TCT TG-3' (FRAG. NO: 152 1)(SEQ. ID NO: 1530) 5'-000 GOB OTT TCB TCT T-3' (FRAG. NO: I 522)(SEQ. ID NO: 153 1) 5'-000 GOB OTT TCB TCT-3' (FRAG. NO:1I523)(SEQ. ID NO: 1532) 5'-000 GOB GTT TCB TC-3' (FRAG. NO: I 524)(SEQ. ID NO: 1533) 5'-000 GOB OTT TCB T-3' (FRAG. NO:1I525)(SEQ. ID NO: 1534) GOB OTT TCB-3' (FRAG. NO: 1 526)(SEQ. ID NO: 1535) GOB OTT TCB TCT TOG CUT T-3 (FRAG. NO: I 527)(SEQ. ID NO: 1536) 0GB OTT TCB TCT TGG CTTr-3' (FRAG. NO: I 528)(SEQ. ID NO: 1537) GOB OTT TCB TCT TOO CT-3' (FRAG. NO: I 529)(SEQ. ID NO: 1538) 5,-GO GOB OTT TCB TCT TGO C-3 (FRAG. NO: I1530)(SEQ. ID NO: 1539) GOB OTT TCB TCT TGG-3 (FRAG. NO: 153 1)(SEQ. ID NO: 1540) GOB OTT TCB TCT TG-3 (FRAG. NO I 532)(SEQ. ID NO: 1541) GOB GTT TCB TCT T-3 (FRAG. NO: I 533)(SEQ. ID NO: 1542) GOB GTT TCB TCT-3 (FRAG. NO: I534)(SEQ. ID NO: 1543) 5'-00 GOB OTT TCB TC-3 (FRAG. NO:1I 535 )(SEQ. ID NO: 1544) 5'-00 GOB OTT TCB T-3' (FRAG. NO:1I 536)(SEQ. ID NO: 1545) GOB OTT TCB TCT TOO CTT T-3- (FRAG. NO:1I537)(SEQ. ID NO: 1546) GOB OTTf TCB TCT TOG CTT-3 (FRAG. NO: 1538)(SEQ. ID NO: 1547) GOB OTTr TCB TCT TOO CT-3 (FRAG. NO:1I539)(SEQ. ID NO: 1548) 5'-G GOB GHr TCB TCT TOO C-3' (FRAG. NO: I 540)(S EQ. ID NO: 1549) GOB OHT TCB TCT TOO-3' (FRAG. NO: I541)(SEQ. ID NO: 1550) GOB OHT TCB TCT TO-3 (FRAG. NO: I 542)(SEQ. ID NO: 1551) GOB OTT TCB TCT T-3 (FRAG. NO: I 543)(SEQ. ID NO: 1552) GOB OTT TCB TCT-3' (FRAG. NO: 1544)(SEQ. ID NO: 1553) 5'-0 GOB OTT TCB TC-3' (FRAG. NO:1I545)(SEQ. ID NO: 1554) OTT TCB TCT TOO CUT T-3 (FRAG. NO:1I546)(SEQ. ID NO: 1555) OTT TCB TCT TOO CHT-3' (FRAG. NO:1I547)(SEQ. ID NO: 1556) OTT TCB TCT TOG CT-3' (FRAG. NO: I 548)(SEQ. ID NO: 1557) OTT TCB TCT TOO C-3' (FRAG. NO 1549)(SEQ. ID NO: 1558) 5'-GOB OTT TCB TCT TOO-3 (FRAG. NO:1I550)(SEQ. ID NO: 1559) OTT TCB TCT TO-3 (FRAG. NO: 155 1)(SEQ. ID NO: 1560) OTT TCB TCT T-3 (FRAG. NO: 1552)(SEQ. ID NO: 1561) OHT TCB TCT-3' (FRAG. NO:1 553)(SEQ. ID NO: 1562) OHT TCB TCT TOO CTT T-3 (FRAG. NO:1I554)(SEQ. ID NO: 1563) 5'-GB OHT TCB TCT TOG CH-3 (FRAG. NO: I 555)(SEQ. ID NO: 1564) OH- TCB TCT TOG CT-3' (FRAG. NO: I 556)(SEQ. ID NO: 1565) OTTr TCB TCT TOO C-3' (FRAG. NO: I 557)(SEQ. ID NO: 1566) GHT TCB TCT TGG-3' (FRAG. NO: I 558)(SEQ. ID NO: 1567) GH- TCB TCT TO-3' (FRAG. NO:1I559)(SEQ. ID NO: 1568) 5'-GB OTT TCB TCT T-3' (FRAG. NO:1I 560)(SEQ. ID NO: 1569) GHTTCB TCT TOO CU- T-3' (FRAG. NO:1I561)(SEQ. ID NO: 1570) OHT TCB TCT TOO CTT-3' (FRAG. NO: 1562)(SEQ. ID NO: 1571) GTT TCB TCT TOG CTT-3' (FRAG. NO:1I563)(SEQ. ID NO: 1572) OTT TCB TCT TOO CT-3' (FRAG. NO:1I564)(SEQ. ID NO: 1573) 5'-B OTT TCB TCT TOG C-3' (FRAG. NO:1I565)(SEQ. ID NO: 1574) OTT TCB TCT TOO-3' (FRAG. NO:1I565)(SEQ. ID NO: 1575) OHT TCB TCT TO-3' (FRAG. NO: 1567)(SEQ. ID NO: 1576) TCB TCT TOO CU- T-3' (FRAG. NO:1I568)(SEQ. ID NO: 1577) TCB TCT TGO CTTF-3' (FRAG. NO:1I569)(SEQ. ID NO: 1578) 5'-GUT TCB TCT TOO CT-3' (FRAG. NO:1I570)(SEQ. ID NO: 1579) TCB TCT TOO C-3' (FRAG. NO:I157IX)SEQ. ID NO: 1580) 272 TCB TCT TGG-3' (FRAG. NO: I 572)(SEQ. ID NO: 158 1) TCB TCT TGG CUT T-3' (FRAG. NO: I 573)(SEQ. ID NO: 1582) TCB TCT TOG CU--3' (FRAG. NO: 1 574)(SEQ. ID NO: 1583) TCB TCT TGG CT-3' (FRAG. NO: I 575)(SEQ. ID NO: 1584) 5'-UT TCB TCT TGG C-3' (FRAG. NO: I 576)(SEQ. ID NO: 1585) TCB TCT TGG CU- T-3' (FRAG. NO:1I 577)(SEQ. ID NO: 1586) TCB TCT TGG CU-3' (FRAG. NO: I 578)(SEQ. ID NO: 1587) TCB TCT TOG CT-3' (FRAG. NO: I 579)(SEQ. ID NO: 1588) TCT TOG CTT T-3' (FRAG. NO: I 580)(SEQ. ID NO: 1589) 5'-TCB TCT TOG CU-3' (FRAG. NO: 158 1)(SEQ. ID NO: 1590) GGB GTTTCB TCTTGGCUTT-3- (FRAG. NO:1582)(SEQ. 1DNO:1591) GGB OU7 TCB TCT TGG CUT T-3- (FRAG. NO: I 583)(SEQ. ID NO: 1592) GGB OU7 TCB TCT TOG CTT T-3' (FRAG. NO: I 584)(SEQ. ID NO: 1593) GUT TCB TCT TGG CUT T-3' (FRAG. NO: I 585)(SEQ. ID NO: 1594) 5'-GB GU- TCB TCT TOG CTT T-3- (FRAG. NO: I 586)(SEQ. ID NO: 1595) GUT TCB TCT TGO CTT T-3' (FRAG. NO: I 587)(SEQ. ID NO: 1596) TCB TCT TGG CU7T-3' (FRAG. NO:1I588)(SEQ. ID NO: 1597) TCB TCT TGG CUTT-3' (FRAG. NO:1I589)(SEQ. ID NO: 1598) TCB TCT TOG CTT T-3' (FRAG. NO:1I590)(SEQ. ID NO: 1599) 5'-TCB TCT TGG CTT T-3' (FRAG. NO:1I591)(SEQ. ID NO: 1600) TCT TGG CUT T-3' (FRAG. NO: I592)(SEQ. ID NO: 1601) GOB OTT TCB TCT TGG CU-3' (FRAG. NO:1I593)(SEQ. ID NO: 1602) GGB GUT TCB TCT TGG CUT-3' (FRAG. NO:1I594)(SEQ. ID NO: 1603) GOB GUT TCB TCT TOO CUT-3' (FRAG. NO:1I595.)(SEQ. ID NO: 1604) 5'-GGB GUT TCB TCT TOO CU-3' (FRAG. NO: I 596)(SEQ. ID NO: 1605) GUT TCB TCT TGG CU-3' (FRAG. NO:1I597)(SEQ. ID NO: 1606) GTT TCB TCT TGG CU-3' (FRAG. NO:1I598)(SEQ. ID NO: 1607) TCB TCT TGG CU-3' (FRAG. NO: I 599)(SEQ. ID NO: 1608) TCB TCT TOG CU--3' (FRAG. NO: I 600)(SEQ. ID NO: 1609) 5'-T TCB TCT TGG CTT-3' (FRAG. NO:1601)(SEQ. ID NO: 1610) TCT TOG CTT-3' (FRAO. NO: I602)(SEQ. ID NO: 1611) 5'-000 GGB OTT TCB TCT TOG CT-3' (FRAG. NO:1I603)(SEQ. ID NO: 1612) GOB OUT TCB TCT TOO CT-3' (FRAO. NO:)I 604)(SEQ. ID NO: 1613) GOB OUT TCB TCT TOG CT-3' (FRAG. NO:1I605)(SEQ. ID NO: 1614) 5'-GOB GUT TCB TCT TOO CT-3' (FRAG. NO:1I606)(SEQ. ID NO: 1615) GUT TCB TCT TOO CT-3' (FRAG. NO: I607)(SEQ. ID NO: 1616) OUT TCB TCT TOO CT-3' (FRAG. NO:1I608)(SEQ. ID NO: 1617) TCB TCT TOG CT-3' (FRAG. NO: 1609)(SEQ. ID NO: 1618) TCB TCT TOO CT-3' (FRAG. NO: I161 0)(SEQ. ID NO: 1619) 5'-T TCB TCT TOG CT-3' (FRAG. NO:) 16)1 1)(SEQ. ID NO: 1620) 5'-000 GOB OTT TCB TCT TOG C-3- (FRAG. NO:1I612)(SEQ. ID NO: 162 1) GOB OU" TCB TCT TOO C-3' (FRAG. NO:1I613)(SEQ. ID NO: 1622) GOB OUT TCB TCT TOO C-3' (FRAG. NO: 1614)(SEQ. ID NO- 1623) OTT TCB TCT TOO C-3' (FRAG. NO: 1615)(SEQ. ID NO: 1624) 5'-GB OU- TCB TCT TOO C-3' (FRAG. NO:1I 616)(SEQ. ID NO: 1625) OUT TCB TCT TOO C-3' (FRAG. NO:1I 61 7)(SEQ. ID NO: 1626) TCB TCT TGO C-3' (FRAG. NO:)I 61 8)(SEQ. ID NO: 1627) TCB TCT TOO C-3' (FRAG. NO:1I 619)(SEQ. ID NO: 1628) 5'-000 GOB OTT TCB TCT TOO-3' (FRAG. NO: 1620)(SEQ. ID NO: 1629) 5,-GO GOB OU7 TCB TCT TGO-3' (FRAG. NO: 162 1)(SEQ. ID NO: 1630) GOB OUT TCB TCT TGG-3' (FRAG. NO:1I622)(SEQ. ID NO: 163 1) GUTTCB TCT TOG-3' (FRAG. NO:1I623)(SEQ. ID NO: 1632) OU7 TCB TCT TGG-3' (FRAG. NO:1I624)(SEQ. ID NO: 1633) GUT TCB TCT TOG-3' (FRAG. NO:1I625)(SEQ. ID NO: 1634) 5'-OTT TCB TCT TOO-3' (FRAG. NO:1I626)(SEQ. ID NO: 1635) 5'-000 0GB OTT TCB TCT TG-3' (FRAG. NO:1I627)(SEQ. ID NO: 1636) GOB GUT TCB TCT TG-3' (FRAG. NO:1I628)(SEQ. ID NO: 1637) GOB GUT TCB TCT TO-3' (FRAG. NO:1I629)(SEQ. ID NO: 1638) GUT TCB TCT TG-3' (FRAG. NO:1I630)(SEQ. ID NO: 1639) 5'-GB OUT TCB TCT TO-3' (FRAG. NOA1631)(SEQ. ID NO: 1640) OUT TCB TCT TO-3' (FRAG. NO: 1632)(SEQ. ID NO: 1641) 5'-000 GOB GUT TCB TCT T-3' (FRAG. NO:1I633)(SEQ. ID NO: 1642) S'-GO GOB GUT TCB TCT T-3' (FRAG. NO:1I634)(SEQ. ID NO: 1643) GOB OUr TCB TCT T-3' (FRAG. NO:1I635)(SEQ. ID NO: 1644) 5'-0 GOB OUT TCB TCT T-3' (FRAG. NO:1I636)(SEQ. ID NO: 1645) GUTTCB TCT T-3* (FRAG. NO:1I637)(SEQ. ID NO: 1646) GUT TCB TCT T-3- (FRAG. NO: 1638)(SEQ. ID NO: 1647) 273 GGB OTT TCB TCT-3' (FRAG. NO:1I639)(SEQ. ID NO: 1648) 5'-00 0GB GTIT TCB TCT-3' (FRAG. NO:1I640)(SEQ. ID NO: 1649) GGB GTTr TCB TCT-3' (FRAG. NO: 164 1)(SEQ. ID NO: 1650) GTT TCB TCT-3' (FRAG. NO: 1642)(SEQ. ID NO: 1651) 5-000 GGB GTT TCB TC-3' (FRAG. NO:1I643)(SEQ. ID NO: 1652) GGB OTT TCB TC-3' (FRAG. NO:1I644)(SEQ. ID NO: 1653) GGB O-TT TCB TC-3' (FRAG. NO:1I645)(SEQ. ID NO: 1654) GOB GTT TCB T-3' (FRAG. NO: 1646)(SEQ. ID NO: 1655) GOB GTT TCB T-3' (FRAG. NO: I647)(SEQ. ID NO: 1656) 5'-GGG GOB OTT TCB-3' (FRAG. NO:1I648)(SEQ. ID NO: 1657) CCC CT-T GTT CCT CCC C-3' (FRAG. NO: I 649)(SEQ. ID NO: 1658) CCT GCT CTG GTG TCT CCT C-3- (FRAG. NO:1I650)(SEQ. ID NO: 1659) CCT CCC TCC CCT OCC-3' (FRAG. NO: 165 1)(SEQ. ID NO:I1660) TTG TCT GTO GOT GTC C-3' (FRAG. NO: 1652)(SEQ. ID NO: 166 1) 5'-GTT TCG CTC TTG TTG CCC-3' (FRAG. NO:1653)(SEQ. ID NO: 1661) GCC CTr CCC TGC TGG-3' (FRAG. NO:1I654)(SEQ. ID NO: 1663) GOB 0-3- (FRAG. NO:1I912)(SEQ. ID NO: 1925) GOT GTC C-3- (FRAG. NO: 1913) (SEQ. ID NO: 1926) BP-1 Nucleic Acids and Antisense Oligonucleotide Frag~ments 2 0 5'-CCGTGTTGTC BGTGGTGCTG CCCGTTTGBG GTBTGGCGCT CCBCCBBTTC CCTTTTCTCC TTGTTTTCCG TTTCTCTTGC CGTCTGTGGT T-3' (FRAG. NO:1914) (SEQ. ID NO: 1927) 5'-CCCGTTTGBGGTBTGGC-3 (FRAG. NO:1915) (SEQ. ID NO: 1928) 5'-GCTCCBCCBBTTCCCTTTTCTCC-3' (FRAG. NO:1916) (SEQ. ID NO: 1929) 5'-TTGTTTTCCGTTTCTCTTG-3 (FRAG. NO:1917) (SEQ. ID NO: 1930) 5'-CCGTCTGTGGTT-3' (FRAG. NO:1918) (SEQ. ID NO: 1931) 5'-CCCGTTTGAGGTATGGC-3' (FRAG. NO:1919) (SEQ. ID NO: 1932) 5S-GCTCCBCCAATTCCCTTTTCTCC-3' (FRAG. NO:1920) (SEQ. ID NO: 1933) C/EBPNucleic Acids and Antisense Olip-onucleotide Antisense Oli~onucleotide Fragments 3 0 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCCCC GGCC-3' (FRAG. NO:1921) (SEQ. ID NO: 1934) OGC 3 (FRAG. NO: 19 22) (S EQ. ID NO: 1935) GCCCCOCCGCCITI7CTBGCCCCOO-3' (FRAG. NO: 1923) (SEQ. ID NO: 1936) 5'-GGGCCCBGCCCCGCCGCCTrTTCTBGCCCCO-3' (FRAG. NO:1924) (SEQ. ID NO: 1937) 5'-GGGCCCBGCCCCGCCGCCTTfCTBGCCCC-3' (FRAG. NO:1925) (SEQ. ID NO: 1938) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCCC-3' (FRAG. NO:1926) (SEQ. ID NO: 1939) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCC-3' (FRAG. NO:1927) (SEQ. ID NO: 1940) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGC-3' (FRAG. NO:1928) (SEQ. ID NO: 1941) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBG-3' (FRAG. NO:1929) (SEQ. ID NO: 1942) 5'-GGGCCCBGCCCCGCCGCCTTTTCTB-3' (FRAG. NO:1930) (SEQ. ID NO: 1943) 4 0 5'-GGGCCCBGCCCCGCCGCCTTTTCT-3' (FRAG. NO:1931) (SEQ. ID NO:1942) 1944) 5'-GGGCCCBGCCCCGCCGCCTTTTC-3' (FRAG. NO:1932) (SEQ. ID NO: 1945) 5'-GGGCCCBGCCCCGCCGCCTTTT-3' (FRAG. NO:1933) (SEQ. ID NO: 1946) 5'-GGGCCCBGCCCCGCCGCCTTT-3' (FRAG. NO: 1934) (SEQ. ID NO: 1947)1[1945)1 5'-GGGCCCBGCCCCGCCGCCTT-3' (FRAG. NO:1935) (SEQ. ID NO: 1948) 5'-GGGCCCBGCCCCGCCGCCT-3- (FRAG. NO:1936) (SEQ. ID NO: 1949) 5'-GGGCCCBGCCCCGCCGCC-3' (FRAG. NO:1937) (SEQ. ID NO: 1950) 5'-GGGCCCBGCCCCGCCGC-3' (FRAG. NO:1938) (SEQ. ID NO: 1951) 5'-GGGCCCBGCCCCGCCG-3' (FRAG. NO:1939) (SEQ. ID NO: 1952) 5'-GGGCCCBGCCCCGCC-3' (FRAG. NO:1940) (SEQ. ID NO: 1953) 5'-GGGCCCBGCCCCGC-3' (FRAG. NO:1941) (SEQ. ID NO: 1954) 5'-GGGCCCBGCCCCG-31 (FRAG. NO:1942) (SEQ. ID NO: 1955) 5'-GGGCCCBGCCCC-3' (FRAG. NO:1943) (SEQ. ID NO: 1956) 5'-GGGCCCBGCCC-3' (FRAG. NO:1944) (SEQ. ID NO: 1957) 5'-GGCCCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. 110:1945) (SEQ. ID NO: 1958) 5'-GCCCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. 110:1946) (SEQ. ID NO: 1959) 5'-CCCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. 110:1947) (SEQ. ID NO: 1960) 5'-CCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. 110:1948) (SEQ. ID NO: 1961) 5'-CBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. 110:1948) (SEQ. ID NO: 1962) 5-BGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1950) (SEQ. ID NO: 1963) 5'-GCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1951) (SEQ. ID NO: 1964) 5'-CCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1952) (SEQ. ID NO: 1965) 5'-CCCGCCGCCTTTTCTBGCCCCGGC-3- (FRAG. NO:1953) (SEQ. ID NO: 1966) 274 5'-CCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1954) (SEQ. ID NO: 1967) 5'-CGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1955) (SEQ. ID NO: 1968) 5'-GCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1956) (SEQ. ID NO: 1969) 5'-CCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1957) (SEQ. ID NO: 1970) 5'-CGCCTTTTCTBGCCCCGGC-3- (FRAG. NO:1958) (SEQ. ID NO: 1971) 5'-GCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1959) (SEQ. ID NO: 1972) 5*-CCTTTTCTBGCCCCGGC-3' (FRAG. NO:1960) (SEQ. ID NO: 1973) 5'-CTTTTCTBGCCCCGGC-3' (FRAG. NO:1961) (SEQ. ID NO: 1974) S'-TTTTCTBGcCCCGGC-3' (FRAG. NO:1962) (SEQ. ID NO: 1975) 5'-TTTCTBGCCCCGGC-3' (FRAG. NO:1963) (SEQ. ID NO: 1976) 5'-TTCTBGCCCCGGC-3' (FRAG. NO:1964) (SEQ. ID NO: 1977) 5'-TCTBGCCCCGGC-3' (FRAG. NO:1965) (SEQ. ID NO: 1978) 5'-CTBGCCCCGGC-3' (FRAG. NO:1966) (SEQ. ID NO: 1979) 5'-GCGBGGCTGTCBCCTCGCTGGGCCC-3' (FRAG. NO: 1967) (SEQ. ID NO: 1980) 5'-GCGBGGCTGTCBCCTCGCTGGGCC-3' (FRAG. NO:1968) (SEQ. ID NO: 1981) 5'-GCGBGGCTGTCBCCTCGCTGGGC-3' (FRAG. NO:1969) (SEQ. ID NO: 1982) 5'-GCGBGGCTGTCBCCTCGCTGGG-3' (FRAG. NO:1970) (SEQ. ID NO:1983) 5'-GCGBGGCTGTCBCCTCGCTGG-3' (FRAG. NO:1971) (SEQ. ID NO:1984) 5'-GCGBGGCTGTCBCCTCGCTG-3' (FRAG. NO:1972) (SEQ. ID NO:1985) 5'-GCGBGGCTGTCBCCTCGCT-3' (FRAG. NO:1973) (SEQ. ID NO:1986) 5'-GCGBGGCTGTCBCCTCGC-3' (FRAG. NO:1974) (SEQ. ID NO:1987) 5'-GCGBGGCTGTCBCCTCG-3' (FRAG. NO:1975) (SEQ. ID NO:1988) 5'-GCGBGGCTGTCBCCTC-3' (FRAG. NO:1976) (SEQ. ID NO:1989) 5'-GCGBGGCTGTCBCCT-3' (FRAG. NO:1977) (SEQ. ID NO:1990) 5'-GCGBGGCTGTCBCC-3' (FRAG. NO:1978) (SEQ. ID NO:1991) 5'-GCGBGGCTGTCBC-3' (FRAG. NO:1979) (SEQ. ID NO:1992) 5'-GCGBGGCTGTCB-3' (FRAG. NO:1980) (SEQ. ID NO:1993) 5'-GCGBGGCTGTC-3' (FRAG. NO:1981) (SEQ. ID NO:1994) 5'-GCGBGGCTGT-3' (FRAG. NO:1982) (SEQ. ID NO:1995) 5'-CGBGGCTGTCBCCTCGCTGGGCCC-3' (FRAG. NO:1983) (SEQ. ID NO:1996) 5'-GBGGCTGTCBCCTCGCTGGGCCC-3- (FRAG. NO:1984) (SEQ. ID NO:1997) 5'-BGGCTGTCBCCTCGCTGGGCCC-3' (FRAG. NO:1985) (SEQ. ID NO:1998) 5'-GGCTGTCBCCTCGCTGGGCCC-3- (FRAG. NO:1986) (SEQ. ID NO:1999) 5'-GCTGTCBCCTCGCTGGGCCC-3' (FRAG. NO:1987) (SEQ. ID NO:2000) 5'-CTGTCBCCTCGCTGGGCCC-3- (FRAG. NO:1988) (SEQ. ID NO:2001) 5'-TGTCBCCTCGCTGGGCCC-3' (FRAG. 110:1989) (SEQ. ID NO:2002) 5'-GTCBCCTCGCTGGGCCC-3' (FRAG. NO:1990) (SEQ. ID NO:2003) 5'-TCBCCTCGCTGGGCCC-3' (FRAG. 110:1991) (SEQ. ID 110:2004) 5'-CBCCTCGCTGGGCCC-3' (FRAG. NO:1992) (SEQ. ID 110:2005) 5'-BCCTCGCTGGGCCC-3' (FRAG. NO:1993) (SEQ. ID NO:2006) 5'-CCTCGCTGGGCCC-3' (FRAG. 110:1994) (SEQ. ID NO:2007) 5'-CTCGCTGGGCCC-3' (FRAG. NO:1995) (SEQ. ID 110:2008) 5'-TCGCTGGGCCC-3' (FRAG. 110:1996) (SEQ. ID 110:2009) 5'-CGCTGGGCCC-3' (FRAG. 110:1997) (SEQ. ID NO:2010) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:199B) (SEQ. ID 11:2011) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCGGG-3' (FRAG. 110:1999) (SEQ. ID 110:2012) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCGG-3' (FRAG. 110:2000) (SEQ. ID 110:2013) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCG-3' (FRAG. NO:2001) (SEQ. ID NO: 2014) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCC-3' (FRAG. NO:2002) (SEQ. ID NO:2015) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGC-3' (FRAG. 110:2003) (SEQ. ID NO:2016) 5'-GCGCGGCCGTCBTGGCGGCGTCGGG-3' (FRAG. 110:2004) (SEQ. ID NO:2017) 5'-GCGCGGCCGTCBTGGCGGCGTCGG-3' (FRAG. NO:2005) (SEQ. ID NO:2018) 5'-GCGCGGCCGTCBTGGCGGCGTCG-3' (FRAG. 110:2006) (SEQ. ID 110:2019) 5'-GCGCGGCCGTCBTGGCGGCGTC-3' (FRAG. 110:2007) (SEQ. ID 110:2020) 5'-GCGCGGCCGTCBTGGCGGCGT-3- (FRAG. 110:2008) (SEQ. ID 110:2021) 5'-GCGCGGCCGTCBTGGCGGCG-3' (FRAG. 110:2009) (SEQ. ID 110:2022) 5'-GCGCGGCCGTCBTGGCGGC-3' (FRAG. 110:2010) (SEQ. ID 110:2023) 5'GCGCGGCCGTCBTGGCGG-3' (FRAG. 110:2011) (SEQ. ID NO:2024) 5.-GCGCGGCCGTCBTGGCG-3' (FRAG. 110:2012) (SEQ. ID 110:2025) 5'-GCGCGGCCGTCBTGGC-31 (FRAG. 110:2013) (SEQ. ID NO:2026) 5'-GCGCGGCCGTCBTGG-31 (FRAG. 110:2014) (SEQ. ID 110:2027) 5'-GCGCGGCCGTCBTG-3' (FRAG. 110:2015) (SEQ. ID NO:2028) 5'-GCGCGGCCGTCBT-3' (FRAG. 110:2016) (SEQ. ID NO:2029) 275 5'-GCGCGGCCGTCB-3' (FRAU. NO:2017) (SEQ. ID NO:2030) 5'-GCGCGGCCGTC-3' (FRAG. NO:201B) (SEQ. ID NO:2031) 5'-GCGCGGCCGT-3' (FRAG. NO:2019) (SEQ. ID NO:2032) (FRAG. NO:2 020) (SEQ. ID NO :2033) 5'-GCGGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAU. NO:2021) (SEQ. ID NO:2034) 5'-CGGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2022) (SEQ. ID NO:2035) 5'-GGCCGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAU. NO:2023) (SEQ. ID NO: 2036) 5'-GCCGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2024) (SEQ. ID NO:2037) 5'-CCGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2025) (SEQ. ID NO:2038) 5'-CGTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2026) (SEQ. ID NO:2039) 5'-GTCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2027) (SEQ. ID NO:2040) 5'-TCBTGGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2028) (SEQ. ID NO:2041) 5'-CBTGGCGGCGTCGGGCCGGGC-3' (FRAU. NO:2029) (SEQ. ID NO:2042) 5'-BTGGCGGCGTCGGGCCGGGC-3' (FRAU. NO:2030) (SEQ. ID NO:2043) 5.-TGGCGGCGTCGGGCCGGGC-3- (FRAG. NO:2031) (SEQ. ID NO:2044) 5'-GGCGGCGTCGGGCCGGGC-3' (FRAG. NO:2032) (SEQ. ID NO:2045) 5'-GCGGCGTCGGGCCGGGC-3' (FRAU. NO:2033) (SEQ. ID NO:2046) 5'-CGGCGTCGGGCCGGGC-3' (FRAG. NO:2034) (SEQ. ID NO:2047) 5'-GGCGTCGGGCCGGGC-3' (FRAG. NO:2035) (SEQ. ID NO:2048) 2 0 5'GCGTCGGGCCGGGC-3' (FRAU. NO:2036) (SEQ. ID NO:2049) 5'-CGTCGGGCCGGGC-3' (FRAG. NO:2037) (SEQ. ID NO:2050) 5'-GTCGGGCCGGGC-3' (FRAG. NO:2038) (SEQ. ID NO:2051) 5'-TCGGGCCGGGC-3' (FRAG. NO:2039) (SEQ. ID NO:2052) 5'-CGGGCCGGGC-3' (FRAG. NO:2040) (SEQ. ID NO:2053) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAU. NO:2041) (SEQ. ID NO:2054) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGGCC-3' (FRAU. NO:2042) (SEQ. ID NO: 2055) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGGC-3' (FRAG. NO:2043) (SEQ. ID NO :2056) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGG-3' (FRAG. NO:2044) (SEQ. ID NO:2057) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGG-3' (FRAG. NO:2045) (SEQ. ID NO:2058) 3 0 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCG-3' (FRAG. NO:2046) (SEQ. ID NO:2059) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCC-3' (FRAG. NO: 2047) (SEQ. ID NO:2060) 5'-CCGCEGGCCBGGGCGCGCCGCCGGC-3' (FRAU. NO:2048) (SEQ. ID NO:2061) 5'-CCGCBGGCCBGGGCGCGCCGCCGG-3' (FRAU. NO: 2049) (SEQ. ID NO:2062) 5'-CCGCBGGCCBGGGCGCGCCGCCG-3' (FRAG. NO:2050) (SEQ. ID NO:2063) 3 5 5'-CCGCBGGCCBGGGCGCGCCGCC-3' (FRAG. NO:2051) (SEQ. ID NO:2064) 5'-CCGCBGGCCBGGGCGCGCCGC-3- (FRAU. NO:2052) (SEQ. ID NO:2065) 5'-CCGCBGGCCBGGGCGCGCCG-3' (FRAU. NO:2053) (SEQ. ID NO:2066) 5'-CCGCBGGCCBGGGCGCGCC-3' (FRAU. NO:2054) (SEQ. ID NO:2067) 5'-CCGCBGGCCBGGGCGCGC-3' (FRAG. NO:2055) (SEQ. ID NO:2068) 5'-CCGCBGGCCBGGGCGCG-3' (FRAG. NO:2056) (SEQ. ID NO:2069) 5'-CCGCBGGCCBGGGCGC-3' (FRAU. NO:2057) (SEQ. ID NO:2070) 5'-CCGCBGGCCBGGGCG-3' (FRAG. NO:2058) (SEQ. ID NO:2071) 5'-CCGCBGGCCBGGGC-3' (FRAU. NO:2059) (SEQ. ID NO:2072) 5'-CCGCBGGCCBGGG-3' (FRAG. NO:2060) (SEQ. ID NO:2073) 5'-CCGCBGGCCBGG-3' (FRAG. NO:2061) (SEQ. ID NO:2074) 5'-CCGCBGGCCBG-3' (FRAU. NO:2062) (SEQ. ID NO:2075) 5'-CCGCBGGCCB-3' (FRAG. NO:2063) (SEQ. ID NO:2076) 5'-CCGCBGGCC-3' (FRAG. NO:2064) (SEQ. ID NO:2077) 5'-CGCBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAU. NO:2065) (SEQ. ID NO:2078) 5'-GCBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3 (FRAG. NO:2066) (SEQ. ID NO:2079) 5'-CBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAU. NO :2067) (SEQ. ID NO:2080) 5'-BGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAU. NO: 2068) (SEQ. ID NO: 2081) 5'-GGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAU. NO:2069) (SEQ. ID NO:2082) 5'-GCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAU. NO:2070) (SEQ. ID NO:2083) 5'-CCGGGCGCGCCGCCGGCCGGGCCG-3' (FRAU. NO:2071) (SEQ. ID NO:2084) 5'-CBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAU. NO:2072) (SEQ. ID NO:2085) 5'-BGGGCGCGCCGCCGGCCGGGCCG-3- (FRAU. NO:2073) (SEQ. ID NO:2086) 5'-GGGCGCGCCGCCGGCCGGGCCG-3' (FRAU. NO:2074) (SEQ. ID NO:2087) 5'-GGCGCGCCGCCGGCCGGGCCG-3- (FRAU. NO:2075) (SEQ. ID NO:2088) 5'-GCGCGCCGCCGGCCGGGCCG-3- (FRAU. NO:2076) (SEQ. ID NO:2089) 5'-CGCGCCGCCGGCCGGGCCG-3' (FRAU. NO:2077) (SEQ. ID NO:2090) 5'-GCGCCGCCGGCCGGGCCG-3' (FRAU. NO:2078) (SEQ. ID NO:2091) 5'-CGCCGCCGGCCGGGCCG-31 (FRAU. NO:2079) (SEQ. ID NO:2092) 276 5'-GCCGCCGGCCGGGCCG-3' (FRAG. 110:2080) (SEQ. ID 110:2093) 5'-CCGCCGGCCGGGCCG-3' (FRAG. NO:2081) (SEQ. ID NO:2094) 5'-CGCCGGCCGGGCCG-3' (FRAG. NO:2082) (SEQ. ID 110:2095) 5'-GCCGGCCGGGCCG-3' (FRAG. NO:2083) (SEQ. ID 110:2096) 5'-CCGGCCGGGCCG-3' (FRAG. 110:2084) (SEQ. ID 110:2097) 5'-CGGCCGGGCCG-3' (FRAG. N0:2085) (SEQ. ID 110:2098) 5'-GGCCGGGCCG-3' (FRAG. 110:2086) (SEQ. ID 110:2099) 5'-GGGCGCBGGCTCCGCB-3' (FRAG. 110:2087) (SEQ. ID 110:2100) 3 (FRAG. NO:2 088) (SEQ. ID 110:2101) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCG-3' (FRAG.11:2089) (SEQ.IDN11:2102) (FRAG .NO:2090) (SEQ. ID NO: 2103) 3 (FRAG. NO: 2091) (SEQ. ID NO:2104) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGC-3' (FRAG. 110:2092) (SEQ. ID NO:2105) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGjG-3' (FRAG. NO:2093) (SEQ. ID NO:2106) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCG-3' (FRAG. 11:2094) (SEQ. ID 110:2107) (FRAG. 110:2 095) (SEQ. ID NO:2 108) (FRAG. 11:2096) (SEQ. ID NO:2 109) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGC-3' (FRAG. 11:2097) (SEQ. ID NO:2110) 2 0 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCG-3' (FRAG. 110:2098) (SEQ. ID NO:2111) (FRAG. 110:2099) (SEQ. ID 11:2112) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCC-3' (FRAG. NO:2100) (SEQ. ID 110:2113) (FRAG. 110:2101) (SEQ. ID 11:2114) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTG-3' (FRAG. 110:2102) (SEQ. ID 11:2115) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTT- 3 (FRAG. 11:2103) (SEQ. ID 11:2116) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCT-3' (FRAG. 11:2104) (SEQ. ID 11:2117) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGC-3' (FRAG. 11:2105) (SEQ. ID 11:2118) 3' (FRAG. 11:2106) (SEQ. ID 110:2119) 3' (FRAG. 110:2107) (SEQ. ID 11:2120) 3 0 5'-GGGCCCCTGGCTCGGCCCCGCGGCCC-3' (FRAG. 110:2108) (SEQ. ID 110:2121) 5'-GGGCCCCTGGCTCGGCCCCGCGGCC-3' (FRAG. 110:2109) (SEQ. ID 110:2122) 5'-GGGCCCCTGGCTCGGCCCCGCGGC-3' (FRAG. 110:2110) (SEQ. ID 110:2123) 5'-GGGCCCCTGGCTCGGCCCCGCGG-3' (FRAG. 11:2111) (SEQ. ID 110:2124) 5'-GGGCCCCTGGCTCGGCCCCGCG-3' (FRAG. 11:2112) (SEQ. ID 11:2125) 5'-GGGCCCCTGGCTCGGCCCCGC-3' (FRAG. 110:2113) (SEQ. ID 11:2126) 3' (FRAG. 110:2114) (SEQ. ID 110:2127) 5'-GGGCCCCTGGCTCGGCCCC-3' (FRAG. 11:2115) (SEQ. ID 110:2128) 5'-GGGCCCCTGGCTCGGCCC-3' (FRAG. 110:2116) (SEQ. ID 110:2129) 5'-GGGCCCCTGGCTCGGCC-3' (FRAG. 110:2117) (SEQ. ID 110:2130) 4 0 5'GGGCCCCTGGCTCGGC-3' (FRAG. 11:2118) (SEQ. ID 110:2131) 5'GGGCCCCTGGCTCGG-3' (FRAG. 110:2119) (SEQ. ID 110:2132) 5.-GGGCCCCTGGCTCG-3' (FRAG. 110:2120) (SEQ. ID 11:2133) 5'-GGGCCCCTGGCTC-3' (FRAG. 110:2121) (SEQ. ID 110:2134) 5'-GGGCCCCTGGCT-3' (FRAG. 11:2122) (SEQ. ID 11:2135) 5'-GGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCCGCCCGGCCCGG (FRAG. NO: 212 3) (SEQ. ID NO10:213 6) 5'-GCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGCCCGG-3' (FRAG. NO: 2124) (SEQ. ID 110:2137) 5'-CCCCTGGCTCGGCCCCGCGGCCCGGYCTTGCCCGiCCCGCCCGG-3' (FRAG. NO: 2125) (SEG. ID 110:2138) 5'-CCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. 110:2126) (SEQ. ID 110:2139) 5'-CCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGFGCCCGG-3' (FRAG. 110:2127) (SEQ. ID 110:2140) 5'-CTGGCTCGGCCCCGCGGCCCOGCTTGCCCGCCCGGCCCGG-3' (FRAG. 110:2128) (SEQ. ID 110:2141) 5'-TGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. 11:2129) (SEQ. ID 110:2142) 5'-GGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. 11:2130) (SEQ. ID 11:2143) 5'-GCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. 11:2131) (SEQ. ID 11:2144) 3 (FRAG. 110:2132) (SEQ. ID 11:2145) 5'-TCGGCCCCGCGGCCCGGCUfGCCCGCCCGGCCCGG-3' (FRAG. 110:2133) (SEQ. ID 110:2146) 3GCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. 110:2134) (SEQ. XD 110:2147) 5'-GGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCG3-3' (FRAG. 110:2135) (SEQ. ID 110:2148) 3' (FRAG. 110:2136) (SEQ. ID 11:2149) 5'-CCCCGCGGCCCGGCTTGCCCC3CCCGGCCCGG-3' (FRAG. 110:2137) (SEQ. ID 11:2150) 5'CCCGCCGT CCGCGCCG3' (FRAG. 11:2138) (SEQ. ID 11:2151) 5'-CCGGCCGGCTTGCCGCCCG)CCCGG-3' (FRAG. 11:2139) (SEQ. ID 11:2152) 5'-CGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. 11:2140) (SEQ. ID 110:2153) 3' (FRAG. 110:2141) (SEQ. ID 11:2154) 277 5'-CGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2142) (SEQ. ID NO:2155) 5'-GGCCCGGCTTGCCCGCCCGGGCCCGG-3' (FRAG. NO:2143) (SEQ. ID NO:2156) 5*-GCCCGGCTJTGCCCGCCCGGCCCGG-3' (FRAG. NO:2144) (SEQ. ID NO:2157) 5'-CCCGGCTTGCCCGCCCGGCCCGG-3' (FRAU. NO: 2145) (SEQ. ID NO:2158) 5'-CCGGCTTGCCCGCCCGGCCCGG-3- (FRAG. NO:2146) (SEQ. ID NO:2159) 5'-CGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO: 2147) (SEQ. ID NO :2160) 5'-GGCTTGCCCGCCCGGCCCGG-3' (FRAU. NO:2148) (SEQ. ID NO:2161) 5'-GCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2149) (SEQ. ID NO:2162) 5'-CTfGCCCGCCCGGCCCGG-3' (FRAG. NO:2150) (SEQ. ID NO:2163) 5'-TGCCCGCCCGGCCCGG-3' (FRAG. NO:2151) (SEQ. ID NO:2164) 5'-TGCCCGCCCGGCCCGG-3' (FRAG. NO:2152) (SEQ. ID NO:2165) 5'-GCCCGCCCGGCCCGG-31 (FRAG. NO:2153) (SEQ. ID NO:2166) 5'-CCCGCCCGGCCCGG-3' (FRAU. NO:2154) (SEQ. ID NO:2167) 5'-CCGCCCGGCCCGG-3' (FRAG. NO:2155) (SEQ. ID NO:2168) 5'-CGCCCGGCCCGG-3' (FRAU. NO:2156) (SEQ. ID NO:2169) 5'-GCCCGGCCCGG-3' (FRAG. NO:2157) (SEQ. ID NO:2170) (FRAU. NO:2158) (SEQ. ID NO:2171) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCC-3' (FRAG. NO:2159) (SEQ. ID NO:2172) (FRAG. NO :2160) (SEQ. ID NO:2173) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGC-3' (FRAG. NO:2161) (SEQ. ID NO:2174) 3' (FRAG. NO:2 162) (SEQ. ID NO:2 175) 3' (FRAG. NO :2163) (SEQ. ID NO:2176) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBG-3' (FRAU. NO:2164) (SEQ. ID NO:2177) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTB-3' (FRAG. NO:2165) (SEQ. ID NO :2178) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCT-3' (FRAU. NO:2166) (SEQ. ID NO:2179) 3 (FRAG. NO:2167) (SEQ. ID NO:2180) 3' (FRAG. NO :2168) (SEQ. ID NO :2181) 3' (FRAU. NO:2169) (SEQ. ID NO :2182) 5'-GGCGGGGGCGGCGGCGCCTGGCTC-3' (FRAG. NO:2170) (SEQ. ID NO:2183) 5'-GGCGGGGGCGGCGGCGCCTGGCT- 3' (FRAU. NO:2171) (SEQ. ID NO:2184) 5'-GGCGGGGGCGGCGGCGCCTGGC-3' (FRAG. NO:2172) (SEQ. ID NO:2185) 5'-GGCGGGGGCGGCGGCGCCTGG-3' (FRAG. NO:2173) (SEQ. ID NO:2186) 5'-GGCGGGGGCGGCGGCGCCTG-3' (FRAG. NO:2174) (SEQ. ID NO:2187) 5'-GGCGGGGGCGGCGGCGCCT-3' (FRAG. NO:2175) (SEQ. ID NO:2188) 5'-GGCGGGGGCGGCGGCGCC-3' (FRAU. NO:2176) (SEQ. ID NO:2189) 5'-GGCGGGGGCGGCGGCGC-3' (FRAU. NO:2177) (SEQ. ID NO:2190) 5'-GGCGGGGGCGGCGGCG-3' (FRAU. NO:2178) (SEQ. ID NO:2191) 5'-GGCGGGGGCGGCGGC-3' (FRAU. NO:2179) (SEQ. ID NO:2192) 5'-GGCGGGGGCGGCGG-3' (FRAU. NO:2180) (SEQ. ID NO:2193) 5'-GGCGGGGGCGGCG-3' (FRAU. NO:2181) (SEQ. ID NO:2194) 5'-GGCGGGGGjCGGC-3' (FRAG. NO:2182) (SEQ. ID NO:2195) 5'-GGCGGGGGCGG-3' (FRAG. NO:2183) (SEQ. ID NO:2196) 3' (FRAU. NO :2184) (SEQ. ID NO:2197) 5'-CGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAU. NO:2185) (SEQ. ID NO:2198) 5'-GGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC (FRAG. NO:2186) (SEQ. ID NO:2199) 5'-GGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2187) (SEQ. ID NO:2200) 5'-GGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAU. NO:2188) (SEQ. ID NO:2201) 5'-GGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAU. NO:2189) (SEQ. ID NO:2202) 5'-GCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAU. NO :2190) (SEQ. ID NO :2203) 5'-CGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2191) (SEQ. ID NO:2204) 5'-GGCGGCGCCTGGCTCGCCTBGGGCCCC-3- (FRAG. NO:2192) (SEQ. ID NO:220S) 5'-GCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAU. NO:2193) (SEQ. ID NO:2206) 5'-CGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAU. NO:2194) (SEQ. ID NO:2207) 5'-GGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAU. NO:2195) (SEQ. ID NO:2208) 5'.(3(C(3CTGGC(TCiCCTGG(3CCCC-3' (FRAU. NO:2196) (SEQ. ID NO:2209) 5'-CGCCTGGCTCGCCTBGGGCCCC-3' (FRAU. NO:-2197) (SEQ. ID NO:2210) 5'-GCCTGGCTCGCCTBGGGCCCC-3' (FRAU. NO:2198) (SEQ. ID NO:2211) 5'-CCTGGCTCGCCTBGGGCCCC-3' (FRAU. NO:2199) (SEQ. ID NO:2212) 5'-CTGGCTCGCCTBGGG(2CCC-31 (FRAU. NO:2200) (SEQ. ID NO:2213) 5'-TGGCTCGCCTBGGGCCCC-3' (FRAU. NO:2201) (SEQ. ID NO:2214) 5'-GGCTCGCCTBGGGCCCC-3' (FRAU. NO:2202) (SEQ. ID NO:2215) 5'-GCTCGCCTBGGGCCCC-3' (FRAU. NO:2203) (SEQ. ID NO:2216) 5'-CTCGCCTBGGGCCCC-3' (FRAU. NO:2204) (SEQ. ID NO:2217) 278 5'-TCGCCTBGGGCCCC-3' (FRAG. NO:2205) (SEQ. ID NO:2218) S'-CGCCTBGGGCCCC-3' (FRAG. NO:2206) (SEQ. ID NO:2219) 5'-GCCTBGGGCCCC-3' (FRAG. NO:2207) (SEQ. ID NO:2220) 5'-CCTBGGGCCCC-3' (FRAU. NO:2208) (SEQ. ID NO:2221) 5'-CTBGGGCCCC-3' (FRAG. NO:2209) (SEQ. ID NO:2222) 5'-GGGTGGGCBCGGCGGCC-3' (FRAG. NO: 2210) (SEQ. ID NO:2223) 5'-GGTCGGCGBI3GBGCTCGTCGTGGC-31 (FRAG. NO:2211) (SEQ. ID NO :2224) 5'-GGTCGGCGBBGBGCTCGTCGTGG-3' (FRAG. NO:2212) (SEQ. ID NO:2225) 5'-GGTCGGCGBBGBGCTCGTCGTG-3' (FRAG. NO:2213) (SEQ. ID NO:2226) 5'-GGTCGGCGBBGBGCTCGTCGT-3- (FRAG. NO:2214) (SEQ. ID NO:2227) 5'-GGTCGGCGBBGBGCTCGTCG-3' (FRAG. NO:2215) (SEQ. ID NO:2228) 5'-GGTCGGCGBBGBGCTCGTC-3' (FRAU. NO:2216) (SEQ. ID NO:2229) 5'-GGTCGGCGBBGBGCTCGT-3' (FRAG. NO:2217) (SEQ. ID NO:2230) 5'-GGTCGGCGBBGBGCTCG-3' (FRAU. NO:2218) (SEQ. ID NO:2231) 5'-GGTCGGCGBBGBGCTC-3' (FRAG. NO:2219) (SEQ. ID NO:2232) 5'-GGTCGGCGBBGBGCT-3' (FRAG. NO:2220) (SEQ. ID NO:2233) 5*-GGTCGGCGBBGBGC-3' (FRAU. NO:2221) (SEQ. ID NO:2234) 5'-GGTCGGCGBBGBG-3' (FRAG. NO: 2222) (SEQ. ID NO: 2235) 5'-GGTCGGCGBBGB-3' (FRAG. NO:2223) (SEQ. ID NO:2236) 5'-GGTCGGCGBBG-3' (FRAU. NO:2224) (SEQ. ID NO:2237) 5'-GTCGGCGBBGBGCTCGTCGTGGC-3' (FRAU. NO:2225) (SEQ. ID NO:2238) 5'-TCGGCGBBGBGCTCGTCGTGGC-3' (FRAU. NO:2226) (SEQ. ID NO:2239) 5'-CGGCGBBGBGCTCGTCGTGGC-3' (FRAU. NO: 2227) (SEQ. ID NO: 2240) 5'-GGCGBBGBGCTCGTCGTGGC-3' (FRAU. NO:2228) (SEQ. ID NO:2241) 5'-GCGBI3GBGCTCGTCGTGGC-3' (FRAG. NO:2229) (SEQ. ID NO:2242) 5'-CGBBGBGCTCGTCGTGGC-3' (FRAU. NO:2230) (SEQ. ID NO:2243) 5'-GBBGBGCTCGTCGTGGC-3' (FRAU. NO:2231) (SEQ. ID NO:2244) 5'-BBGBGCTCGTCGTGGC-3' (FRAU. NO:2232) (SEQ. ID NO:2245) 5'-BGBGCTCGTCGTGGC-3 (FRAU. NO:2233) (SEQ. ID NO:2246) 5'-GBGCTCGTCGTGGC-3' (FRAU. 110:2234) (SEQ. ID 110:2247) 5'-BGCTCGTCGTGGC-3' (FRAU. NO:2235) (SEQ. ID 110:2248) 51-GCTCGTCGTGGC-3' (FRAU. NO:2236) (SEQ. ID 110:2249) 5'-CTCGTCGTGGC-3' (FRAU. NO:2237) (SEQ. ID 110:2250) 5'-TCGTCGTGGC-3' (FRAU. 110:2238) (SEQ. ID 110:2251) 5'-GGGGCCCCGCGCCGCCCGCC-3- (FRAU. NO:2239) (SEQ. ID NO:2252) 5'-GGGGCCCCGCGCCGrCCCGC-3' (FRAU. NO:2240) (SEQ. ID 110:2253) 5'-GGGGCCCCGCGCCGCCCG-3' (FRAU. 110:2241) (SEQ. ID NO:2254) 5'-GGGGCCCCGCGCCGCCC-3' (FRAU. 110:2242) (SEQ. ID 110:2255) 5'-GGGGCCCCGCGCCGCC-3' (FRAU. 110:2243) (SEQ. ID 110:2256) 5'-GGGGCCCCGCGCCGC-3' (FRAU. 110:2244) (SEQ. ID NO:2257) 5'-GGGGCCCCGCGCCG-31 (FRAU. 110:2245) (SEQ. ID NO:2258) 5'-GGGGCCCCGCGCC-3' (FRAU. NO:2246) (SEQ. ID 110:2259) 5'-GGGGCCCCGCGC-3' (FRAU. 11:2247) (SEQ. ID 110:2260) 5'-GGGCCCCGCGCCGCCCGCC-31 (FRAU. NO:2248) (SEQ. ID 11:2261) 5'-GGCCCCGCGCCGCCCGCC-3' (FRAU. 11:2249) (SEQ. ID NO:2262) 5'-GCCCCGCGCCGCCCGCC-31 (FRAU. 11:2250) (SEQ. ID 110:2263) 5'-CCCCGCGCCGCCCGCC-3' (FRAU. 110:2251) (SEQ. ID NO:2264) 5'-CCCGCGCCGCCCGCC-3' (FRAU. 11:2252) (SEQ. ID 110:2265) 5'-CCGCGCCGCCCGCC-3' (FRAU. 110:2253) (SEQ. ID NO:2266) 5'-CGCGCCGiCCCGCC-3' (FRAU. NO:2254) (SEQ. ID 110:2267) 5'-GCGCCCGCGCC-3' (FRAU. 11:2255) (SEQ. ID 110:2268) 5'-CGCCGCCCGCC-3' (FRAU. 11:2256) (SEQ. ID 11:2269) 5'-GCCGCCCGCC-3' (FRAU. NO:2257) (SEQ. ID NO:2270) 5'-GGGGCGCGCGGGGCCGCCGGG-3' (FRAU. NO:2258) (SEQ. ID 110:2271) 5'-GGCGGGGBGCGGCBGGGCCCGGGCCC-3' (FRAU. 11:2259) (SEQ. ID NO:2272) 3 (FRAU. 110:2260) (SEQ. ID NO:2273) 5'-GCGCGGGCBBCBGCGBGCCGGGCGCG-3' (FRAU. 11:2261) (SEQ. ID NO:2274) 5'-GCGCBCGGGCCCBCCTGCGCGGGC-3' (FRAU. 110:2262) (SEQ. ID NO:2275) 5'-GGGCGGGGTGGGTGCCT'G(CGGCCGC-3' (FRAU. 110:2263) (SEQ. ID NO:2276) 5'-GGGCTGCTGCGCGGCGGCTCCGGCGA-3- (FRAU. 110:2264) (SEQ. ID 110:2277) 5'-CTCCCGGGCGGGGCCGGGCGCGGGG-3' (FRAU. 11:2265) (SEQ. ID 110:2278) 3 (FRAU. NO: 2266) (SEQ. ID NO:2279) 5'-GCGCTCGCGCCGCTGCCGG-3' (FRAG. 110:2267) (SEQ. ID NO:22B0) 279 5'-GCGCCGCTTGGCCTTGTCGCGGC-3' (81RAG. NO :2268) (SEQ. ID NO:2281) 5'-GCTGCTCCBCGCGCTGG-3' (FRAG. NO:2269) (SEQ. ID NO:2282) 5'-GCCGGBGGCCGGCCBGGTCCCGCG-3' (FRAG. NO: 2270) (SEQ. ID NO: 2283) 3' (FRAG. NO :2271) (SEQ. ID NO:2284) 5'-GTCTCTCCCGCCCCGGCCGCGCG-3- (FRAG. NO :2272) (SEQ. ID NO :2285) 3 (FRAG. NO:2273) (SEQ. ID NO:228 6) 5'-GCGGGCACGCGGCGGCTCTGGCGTCGGC-3' (FRAG. NO:2274) (SEQ. ID NO:2287) Bradvkinin Receptor Nucleic Acids and Antisense Oligonucleotide Fragments BGCBTGTCGG CGCGGTCCCG TTBBGBGTGG GCCCGCCAGC CGGGTGGCCA GCACGAACAG CACCCAGAGG AAGGGGGGCG GCCCAGAAGG AGGTCTGCTG CGGCCGGAGA TAATGGCATr CACCACGCOG CGGCCCAGCG GGTTCTGACC TGCAGCCCCC GTCTCCT-fGG CATTCCTGGG CCCCAGTCAC CTGGGGCAGG GACGGGGTG BCBTTGBGCB TGTCGGCGCG GTCCCGTTBB CCACTCCACT TGGGGGCGGG TGGCCAGCAC GAACAGCACC CAGAGGAAGG CCCGCAGGCC AGGATCAGGT CTGCTGCGGC CGGAGATAAT GGCATTCACC CCGCGCATCC GGCCCGGGTT CTGACCTGCA GCCCCCGTCT CCTTGGCATT CTCCCTGCCC CCCTTGCTGG GGCAGGGACG GCCGTGTTGT CBGTGGTGCT TCCBCCBBTT CCCTTTTCTC CTTGTTTTCC GTTTCTCTTG CCGTCTGTGG TT CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATr GTTGCTUTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTrTGCAGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCA'TrACTGT CCAGCCACTC CACTTGGGGG GCAGCCCGCA GGCCAGGATC CACGCCGCGC ATCCGGCCCG TCCTCTCCCT GCCCCCCTTG GBGTGGGCCC GCCAGCCCAG GGGGCGGCCC AGAAGGGCAG ACGCGGCGGC CCAGCGCACG CCTGGGCCCC AGTCACTCCT GCCCGTTTGB GGTBTGGCGC CAGATTCACA AACTGCAGGA TGTGTAAGGA TfGAGGGACA CCTTGGGAAA TGAGTTGATG GAGCATGGCT GTGAGGATGG TCTTATTTGC TGCCACACCT GGAGTGACTG AGCrI7CCCTC AACTGCCATC CAGCTTTGGT TTCAGCTAGA ACTTTGAAGG ACCTGGAGAC CAGGATTTTA TAAGCACATA TITGAGCACTT AGCCATCTCC ATCT-FGAAGG TGTTCGACGA GACGGTCGAG GCTCAACCAA TAACTATTGC GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAAC'FrAGA GCAATGGCTG AGTGCACAAG TGAGTTGTTGj CCCTGGGT ACAA1TTCTT GCATTAATAA TGGCTCCCCT CACTGATGGA GCTGTATATG CAGTATTrGAG AACTCAAAGA CTCAAGTGGG CAGGGTGCTG TGGGTGATAT ACAACCACCT GTCCCTGCCT CAGGTATAAA GTACTTAGAA GGATATGT[- ACTATAAGGA

AGGTTAAGCC

CAAGGAGGTC

CACTGTAGGC

AACGACTGGG

CTGAGGGGTC

TGTGCCAAAG

AAGACCCAAG

CACTGCCACC

GGGAGGGAGA

TCTCCAGGAG

CTTTAATCTA

CCTGATAACA

AAGAATCCAA

AAAGAGAAGG

ACCAGAAAGC

GGACAGCAGA AGGGGGAGAC CAAGGTTCCA CAGTTCCCTT TTATGTAACA TGAAGTCG'FF GTGAGGGTTA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT

AAGGCAGTAA

GACGTAACTG

CAGTATTGGG

AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA YI7CCCACCAC CCTGAGGCCC TCTGATTrGT GATGAGGCAG CCCCACCACC AGCCGGTACC ACCAAGGGAT TGTTCCTGTC AAAAGGAATG GCAATGGTGT T-rATTAGCTG GTTGGAGAGC CCTGGAGAGG CTAGAACCAA CAACCGCCAC ACACACAGGA GCATfTGGAG AGAAGGCCAT AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC AATCAATGGT TTA'ITGGAAG GTGGCCCAGT ATGAGCCCTA TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT

GTCTTCAAAG

TGCTGAGACC

TGTCTCAGCA

GAAGAGTGTG

AAATGAATAT

AGGGCTAGAA

AAAACCTGAG

CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG

GAGAGCTAGA

AATCTGGAGA

GGCTAGAACC

CTGGAAGGGC

TAGAACCTGG

CCATAAATCC

CCCAACCCAC

TGAAAGAAGA

ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC TCTTTTrrTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTT17GT CACACAGGGC AGTCATTCAG TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAGACTCAAT GAGCTGTTAT GYJTGTAAACA GTGTCTT-rTC TGTAGAGCAT AATAAATGGA CCGTCAATAA TTTGTTAAAT GCTT'TfAAA TCCCAGCACT rFGGAGCCGA GCGGGTGGAT GCAAAACCTC ACTCTCTACC AAAAATACAA TACTCAGGAG GCTGAGACAG GAGAATCGCT CATTGTACTC CAGCCTGGGT GACAGAGAGA GCTTCAAACA CATGATCTCT CACCACTGTT GAAAGCTCCT AGGTCTUCCT TTCCCTCTGC CGTTGCATCC T[-GCAAGTG TCCAAACCCT GGTGTTAATT ACCTCCCACT TCATTTCCTG GGAAGCAMT CACATCCAAA TGAGGTTTTT GCAAAAAAAA ATGAATGCTT TAAGCCGGGT TGTGTGAGGT CAGGAGTTCG AAATTAGCCA GGCATGGTGG TGAACCCGGG AGGCAAGGTT GACTCCGTCT CAAAAAAAAA GAATTTTCTT TCTATGAGCC AAACTCCCTG CCTGAAGGT GATCCCAGCT GTGCTrAGGG TflACCAACT CAGCTTTTTG CACCAGAGCA CGTGATGGTC ACACCTGGTC TGAGGGGCAA AAAGAACATC TGTCCTGTGA CGAGAAAATC ATGTAAACAT AAAAAAAAA AAATGATAGA GCAGTGCCTC ACATCTGTAA AGACCAACCT GGCCAACATG CAGGCACCTG TGATCCCAGC GCAGTGAGCC AAGATTACGC AAAAAAAAAA AAAAAATTAC CAGGAGGGCC TCTCAGAGAG TCAGAAGGAC TGTGCGTGCT GTTCCTGCAA ACCTITCCA TTTI'AGTGTG TITGAATTCC GGGCTTCTGG AAACCCAGGT ACATTCATGC ACACACACAC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT 280 ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCT-TTCCACA CCCTfCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTrGGG AAAAAAGGCC CITJTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC 'ITGACAGCAC CT-rGTAAT[G GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTrAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATJ7CT CCAAAGAACC TCCCCTAA CAGTTCCAGC C1TrAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTITGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGOAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTrCC TGAGCAGCAG CCAGGGCCTA ATCGATAUTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTrTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTr TGCTrGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TOTOTOGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCA117TCTCC GCCCTGCTGG AGAATGCGTG TATGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TITCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GITUTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTrTCAGGT GAGTCAAAGG GATTCCTCAG TrCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTJTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGT[ ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTr AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATfGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTrGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCU-GGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTITTCTGT AGCTACAGAA ATGGGGTTGA GGGT-rGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTFC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCYrGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC ITCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAAT-rCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTTITTTAG AGCATACYUC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TrAGCACCCA GTGAAGACCA CGCTrACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CAC17TTCCAG AACATACCAA CAGCTJTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTrCT-FGTC CGGTCAAAAT GCTTCTTATC CT"TCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCFTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTrTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA

TCTCTCCCGT

CCCTTCCT

GCTTTGGACT

GACTCGTAGT

TCTCTCACCC

TT-rCAGTGTG

TCAGCTCTTC

ACAGCACAGG

TCTCGCATCC

CTCCATGAGC CTGACTATCA GTGGACCTrC CAGAAAGAGC GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT ACTCTI1CAAC TrGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AAYUFACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTMAC CACTGATAAT AAGGGTGCAA AATGTAAATr ACTAATGMrI AT-TGAGCCTA GTGCAGTGCG TGGGGCATTrF TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTT7AA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTfA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCT11TGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TT-rCTCTTrT AATAAATTAA CTCACCCACC ACACGGCT GAGAGGCTCA AAGTFTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGYT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGT-rGTCCT TAACCCCTGT CTCCT-rCTGG ACCAGTTTTr GTCCTTrCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTITTC CACTCTT-r CAGCGCCGAC ATGCTCAATG TCACCTI7GCA AGGGCCCACT CTTAACGGGA CC'rrTGCCCA GAGCAAATGC CCCCAAGTGG 281 AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTFCCT CTGGGTGCTG 11TCGTGCTGG GAACATCTT-r GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCGACTGGCT CTTTGGGGAG ACGCTCTGCG GCGTGGTGAA TGCCATTATC TCCATGAACC CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC

ATGCGCGGCG

CCATGCTGGT

CTACCCATCC

AGTGTCATCA

AGATCCAGAC

GCCCTUCCAG

CGCATCATCG

TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT CTCATCTGGG AAGTGYITCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA

CCACCCTAGA

CTACCTGGGG

TCCAACAACT

TGTACAGCAG

CATGGGCCGG

CTGAGCTCAC

GTGTCATCAG

GCTGCCCCTG

AAGTTCAAGG

TCTGCTGGCT

CCAGGACGAG

AACCCACTGG

GCCAGAAAGG

CTCCGTGGAA

GCTGCTGTGA

CATCTATGCA

CCAAYTTGC

ACAGCATTAC

ATCAGCACCT

ATGTAATCAC

TGTACGTGAT CGTGGGCAAG GGGCTGCAGG TCAGAACCCA CGCCAGAT-rC ACAAACTGCA ATTITGTGTAA GGATTGAGGG CGACCTrGGG AAATGAGTTG AGGGAGCATG GCTGTGAGGA TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG ACAGATCGCC TCCUTCATGG CCTACAGCAA CAGCTGCCTC CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT T-rCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG ACAGTITGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA TGTTCT-rATTr TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTATTCAGCT AGAACTTTGA AGGACAATIT ACAACCTGGA GACCAGGATT TTATGGCTCC CAATAAGCAC ATATTGAGCA CTTGCTGTAT AGGAGCCATC TCCATCTTGA AGGAACTCAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG TTFCTCCGTCC CTGCCCCAGC AAGACAACTT CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG CTTGCATTAA TAAAGGTTAA GCCCTGAGGG CCTCACTGAT GGACAAGGAG GTCTGTGCCA ATGCAGTATT GAGCACTGTA GGCAAGAGGG AGACTCAAGT GGGAACGACT GGGCACTGCC CTGTGGGTGA TATGGACAGC AGAAGGGGGA

AGATCTCCAG

TTTCTIfTAAT

GTCCCTGATA

AAGAAGAATC

kIAGAAAGAGA

ACCACCAGAA

GCCAGGTTCC

TCCCGCCGCC

TCAGGCTGCC

GGGCAGGGGC

GAGGGCAGGC

AGCTCACCAA TACTATTOCA CACCACCTGT CCTGCCTC GCCCTTCAAA GATGAGCTGT ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGC1TG CTCCGGAGAA GGTGGGTGCC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG

AGCGGGGAGA

GATGAGGCTC

CCATAGACCT

CCAGGTGCAC

TCACAGCCAA

GATOATOGGA

ATGGGCTGGG

CTCTITCTGAA

ACCGTCTCAG

AGCCTGAGCC

GCGCAAACAC

GACAAAGAAA

ACTGTTTACA

TTACGCGAGG

GCCGTCCCAC

AGTTTCCCTG TGGTCGTGGG GAGTT GAGCTCTTCA ATAT-T-rrAGT GAAAGCTATA CATAGOGGAT AAAGCACAGA CACACCTTTTf CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT TCAGGCTTGA -FGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC

GGAAGGGT

CCCTGGGAGT

TTGACATGGG

CCGTACCCAG

TCCCAGGACT

TCCAAAACTC

CAAATTTATT

GACTCCAACG

TAAGGCTUCA

GTAAAGTGCT

AGAAACCTCC

AAAAAAAATG

GCAGATAGTT

GCCATACATC

GAAACAGGAC AGCTTCTGCC CCCAGGGCTC AGAGGGTGGC GGCTCCAGCT GGGCAGGAGT CACTACCCAG CCCYITCAAAG GGGTGGGGAC GGTGGTGACG TGCCGCTTGC TCCGGAGAAG CAAACTGTCC CAGCACAGAG AGTTGGGAAA AGTTCCCTTC AGCAGACAGT GAGCAAACGC AGCATGGGCC CAGGAATGCC AACACCGGAG ACTAATTCCT CGCACAGCCA AGGACTCCAA GCTCCTTCCC AGGAGTGGAG TCCGTCCCTG CCCCAGCAAG AGTGCACAAG TGAGTTGTTG GCATTrAATAA AGGTTAAGCC CACTGATGGA CAAGGAGGTC CAGTATTGAG CACTGTAGGC CTCAAGTGGG AACGACTGGG TGGGTGATAT GGACAGCAGA

CCGCCTGCCC

AGACACAAAA

CACATGGGGC

GGCAGCCGGG

AGAGCGGAGA

GCAGAGCTCA

ATGAGCTGTT

GTGGGGACAT

GTGGGTGCCG

GGAGGGAGGG

ACCTGGCCAC

TAACCACCTC

TTrCCCAGGCC

CCTACGCAAA

GCGAAGGTGG

GCTGGAGGCG

CCCGCCGCCA

CAGGCTGCCC

GGCAGGGGCT

AGGGCAGGCA

TTTTFGAAAGT

AGTAAGTCTT

TCCGAAGAAA

ACTGTCGCCC

CCTCTGTTTA

AAGAAGATAA

ACTTTGTGGT

CATGGAAATC

CCGCAGCCTT

AGGGGGAAGT

CTCCAGCTCT

TGGGCCCACT CYJ7ATCTGTT CCCTGCCC'rr TCCAGCTCCT TGAGCAAAAC TGAGAAAGCC CGGCCGCGTG TCTCAGGGGA TTrGGGAGCCG TACGTGGCAT CACCTTCCGC GTAAACGCCC ATAATGATAA GAAATAAATG CAGCCGGGAG GGACGTTTYU TTCCAAGAGC CTCCCTGGCC CCCGGCCCCA CAGCCAGCCT GCCCAGGAGG CTGATGACAT GGCTTCTGGG CTCCGAGGAG CGCAGTACCA GGGAGCGACT GAAGTGCCCA GCTCCAGCCG CCTCACCTCT GCTGGGAGGA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG CTJTCCGGAGG GAGG CAGATTCACA AACTGCAGGA CTGGGCAGGG CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTrGAGGGACA AAGGAGACAT CTATGCACGA CCT-rGGGAAA TGAGTTGATG GCCCTGCCCA AYI=GCAGG GAGCATGGCT GTGAGGATGG

GTTGCTFT[C

TCTCCGGTAA

GGTGAACTCA

AATCACAACA GCATTACTGT

GAGGCCTGGG

ACAACTTAGA

CCCTGGGT

CTGAGGGGTC

TGTGCCAAAG

AAGACCCAAG

CACTGCCACC

GGGAGGGAGA

TCTCCAGGAG

CTTrAATCTA

CCTGATAACA

AAGAATCCAA

AAAGAGAAGG

ACCAGAAAGC

TCTfATTTGC TGCCACACCT GAGCCAGCCT GGAGTGACTG AGCTTCCCTC CCGTGTGTTC AACTGCCATC CAGCT117GGT GCAATGGCTG UTCAGCTAGA ACTTTGAAGG ACAATTrCTT ACCTGGAGAC CAGGATTA TGGCTCCCCT TAAGCACATA TTGAGCACTT GCTGTATATG AGCCATCTCC ATCTTGAAGG AACTCAAAGA TGTTrCGACGA GACGGTCGAG CAGGGTGCTG AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTfT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATrGGG AGCCGGTGGC 282 GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTFCTAATCGG TCUTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TrATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTJ7ACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT T~rAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTITACC CCCAACCCAC TCTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTAT1TAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTITTGT CACACAGGGC YJ7AGGAGCAG AGCTCTGCCG CAATGGCCAT GGGAGAAGAG CGGCCCTATG CATGGTGTAG GAGCTGTTAT GTTGTAAACA TGTAGAGCAT AATAAATGGA T-rTGTTAAAT GCTITTTAAA TYFGGAGCCGA GCGGGTGGAT ACTCTCTACC AAAAATACAA GCTGAGACAG GAGAATCGCT

GGAAGCATT[F

TGAGGTTTTr

ATGAATGCTT

TGTGTGAGGT

AAATTAGCCA

AGTCATTCAG

GTGGGGATCC

ATGCCCTGAT

CACATCCAAA

GCAAAAAAAA

TAAGCCGGGT

CAGGAGYI'CG

GGCATGGTGG

CACCAGAGGA CGTGATGGTC ACACCTGGTC TGAGGGGCAA AAAGAACATC TGTCCTGTGA CGAGAAAATC ATGTAAACAT AAAAAAAAA AAATGATAGA GCAGTGCCTC ACATCTGTAA AGACCAACCT GGCCAACATG CAGGCACCTG TGATCCCAGC

TGAGACTCTC

CTGAGTCTGC

AAGACTCAAT

GTGTCTTTTC

CCGTCAATAA

TCCCAGCACT

GCAAAACCTC

TACTCAGGAG

CATTGTACTC

GCTTCAAACA

GAAAGCTCCT

CGTTGCATCC

GGTGTTAATT

CTGAACTGAC

GCCGGGTG'TT

CAGCCTGGGT

CATGATCTCT

AGGTCTTCCT

TTTGCAAGTG

ACCTCCCACT

CGTTGTCTGA

GCAGAGTGGC

CCACACATGC

CCCYJ7CCTAG

TAAGCCCCAC

TGTGAGGCAA

AGCAAGGGTC

GGCTGAGAAC

CTGTCTCCCT

CCTCTGAGCT

CCAAAGAACC

AAATCAGCCC

CCATCCATGT

AGTCTCCATC

CCTGACYTCC

TCCTGCACCA

CCTCACAGGC

YTAGGTCAGT

CATTGTATAC

CCAT'I1CTCC TTCYrCTCTG

AGATATCAAT

GATTCCTCAG

GACAGAGAGA

CACCACTG1TT

TTCCCTCTGC

TCCAAACCCT

TCATTTCCTG

TCTCCACCTC

TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA T[ACCAACT CAGCfTITG TTAGTGTG T-fTGAATFTCC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTfCCACA ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT

CTCTAGCCAT

GCACAGAGCC

GGGAATGGAA

TTGACAGCAC

TATTAGGTTC

CCAGACCCTG

TCCCCTTTAA

CCCATCTCTG

CCAATCAAGC

ATCCCAGGTC

TGAGCAGCAG

TCATCCCTCC

GCGTTTGGGA

TTGCAGTTAT

CTAGCACCGC

GCCCTGCTGG

TTCAGCCCAG

GTITTCTGTCT

GGGACTGAGA

CATGCCTGCC

GGCCC'FrGGG

CTJTGTAATTG

AAAGTCCCTC

CTGGACCCAA

CAGTTCCAGC

CCTITGCAGG

ACTAGGCATG

GAAGCTAATG

CCAGGGCCTA

ACCCTGTTTA

CCCCATGTTC

TAAGTGACTG

TGTGTGGGAG

AGAATGCGTG

GTGTGGCCTC

GUrCGTGAGG CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AAAAAAGGCC C'TfCAACTA GGGGCACAGA GGAGGCCCTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTrCT CTT-rAACAGT TCCAGTCTAA ACACATGACC YJ7TCTCCTCT AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC GGCTAACTGG TCC'FrGC'rrC CACTCTACCC CCACTGCAGT ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC TATGCTCTCA CAGGACCTTT TGCTTGATT[ TTCACTGTAC AGCAATGTCT GGCT1TCTCCA GTAGACTGTC AGCTCCTAGC CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT TATT-rGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA ACTCCGTGCC CACCACGGCC TC1TTTCAGGT GAGTCAAAGG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC TTCACTAGTT AGGGGAGGTG ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGFI7G GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGYJ7GTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTrrGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCA'TTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATOOCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTrTCCAA Tf~CCGCACTC AGCAGGCATC ThUTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTFITTCTGT AGCTACAGAA ATGGGGYTGA GGGTUGGACC AAGGGACTAC CCAGGGGAAG TC'rrACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA 283 AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTrCCCCCC

ATGTGGCTGC

AGATGCTGCA

CCAGCCCACG

GGCATATGAA

CTJ7AAGACTC

CTCTTGCTAC

AGTTCTGTGC

GCTTCTTATC

CTGTGTCCCA

GGCAGGGCAG

CGCTCAAAAA

CAGCTGCTCC

GACTCGTAGT

TCTCTCACCC

'TrTCAGTGTG

ATTCAGGATG

CCAAGACCAC

AATTACAGCA

GCCAGTGGGT

AATGTAAATT

TATGACAACC

TAAGTAACT[

GGCTGCAAAG

TAACGGAAAT

CAAGCCAGAC

ACACGGC1TT

AATCCTCCCA

ATACTGGCCA

ATCAGAGGGG

AGCTCCACCT

GTCCTTCCCT

TCACCTTGCA

CTGGCTCAAC

GTCCTCAGCG

CAGCAGACCT

CTTrGGGGAG

CTGATGCTGG

TGCGCTGGGC

GTTCCGGACC

CTCATCTGGG

CCTTCTGCAC(

TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA

AAGATGTTAT

TCCAGGAGAA

AGCCACCACA

AGGGGCAAAG

TTCCCACCTC

CTCTGCTCAG

CTrCAAGACC

CAACCCCCCT

GACCTAGCCT CAGAAATCAC GAGGAAGCAG ATTrCCTCCTT CACCACAGGG ATCT-rTTTAG CCTCACTTCC TrAGCACCCA TCCTGTCCAA CATCTAGTGT

ACACCATCCC

TTGAAATGAA

AGCATACTFC

GTGAAGACCA

CACTTTCCAG

CACTTGTCCT

ACCCCTTACC

TGCCACCATT

GAATATCAAG

TTATACCATC

CGCTTACTCC

AACATACCAA

CC17CTTGTC

CACCAGCCCC

GCTGTTCCCC

CAGCTCTAGA

GCTCCCTCCA

GGGCCGGGTG GTGTCTTCTT ACATTTAAAG GATAGAAGCA TAGAAGCAAA CGGACTTFTC TCAGCTCTTC CTCCATGAGC

CTGCCTGGTC

GTCACCTCCA

GGGCACCCTC

TGTGTTCTTG

TTGATTTGTG

CTGGGAAATC

CTGACTATCA

CACCCTCTGG GCCACAGTTG CACTCAGGGC AGAGCTCAGC GGTCCCCCAG TCTGGCTCCA CCAGAGGTGA TGATCAGTAA GTGGACCTTC CAGAAAGAGC

AGTAAGAAGT

TAATTCGGGG

ACTGTAGTTC

CTCACTCAAC

CAGCT'TCCCC

CGGTCAAAAT

CTCTCCAAGT

TCAGGAGTCA

ACAGAGCAGA

GGATGCCAGC

TCTCTCCCGT

CCCTITTTCCT

ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG CTGAGAGGTA GTGGTTTTAA CTGCCATGTT CCCCAGCGTG ACACGGCTrA TAAGTAAGGC TCCCCACCCC CCTCGCCATC TGTATCCTCC CACGATGCCA CAGACTGTCC AGGAAGACAG TGGAATCTCC AGGTCTGGAA TGATATCATT

GAGAGGCTCA

TCACGGAAGC

AGGAAATATC

GCTCTGTAAG

CGGCTTCTCC

TGTGACCGCT

AGGGCCCACT

ACCATCCAGC

AAGTTGACCA

TITCAAGGAGG

CCAGTGGAGC

ACCCAGGGGA

YUTGTCCTGGC

GAGGGGTAAC

CTrAACGGGA

CCCCCTTCCT

ACTCCCTTGG

TCAAGGGTCC

CTCGAGATGA

GTCAGGTGCA

TGGTTGTCCT

AGCCTCTTTC

CC'TrGCCCA

CTGGGTGCTG

AGCTGCACGG

CCTTCTGGGC

TGCCATTATC

GCCCTGGTGA

TCTGGGGGTG

GGGCCACAAC

CTGAATGTCG

ATAGAAGCTC

AGCCCCATGC

CTGTGAGTCT

TGGAGTTTAC

TGGGGCATYI'

ACAGGTGAGG

AGCCAGGATG

AATCACTTCA

AAACTAGGCA

TITCTC'FfTT

GAGGGCCCCG

AACACTTGAG

AGAACATGAG

CTGGAGCGCG

TAACCCCTGT

CAC'TTCTTT

GAGCAAATGC

TTCGTGCTGG

TGGCAGAGAT

CATCACCATC

TCCATGAACC

AAACCATGTC

TACGCTGCTC

GTCACCGCTT

TGGGCTI7CCT AGAGAGATCA AGCAATTTGC CTCTGCTGAA GGTAGAGATG TGCCTAAGAA TGAAAGAGGA CACTGATAAT AAGGGTGCAA TGCACATTGT CTCTGATCCC TCATTGTGGT TCAAGGACGT TGAACCCAGT AGGACTATCT GTGCTfTGCT GCATAGAAGG GATGGGCTGG CCATGGTCTC AATAAATTAA CTCACCCACC GTTGATAAGG AAGGAACGTG ATTFGT-AGTG CTGTTGGTGG GCCCCCG17T AGAACCAAGG GGCATGCAGA AAACAGCCTG CTCCTTrCTGG ACCAGTTrTT CAGCGCCGAC ATGCTCAATG CCCCAAGTGG AGTGGCTGGG CCACCCTAGA GAACATCTTT CTACCTGGGG AACCTGGCCG TCCAACAACT TCGACTGGCT TGTACAGCAG CATCTGTC CATGGGCCGG ATGCGCGGCG CTGAGCTCAC CCATGCTGGT GTGTCATCAG CTACCCATCC GCTGCCCCTG AGTGTCATCA AAGTTCAAGG AGATCCAGAG TCTGCTGGCT GCCCTTCCAG TCTrCTGCCT GCACAAGAGC

GATCCTGGCC

ACGCTCTGCC

TGAGCATCGA

CAAGCTCTAC

ATGAAGGAGT

AAGTGTTCAC

GATGCAGATC

TGCGGGCTGC

GCGTGGTGAA

CCGCTACCTG

AGCTTGGTGA

ACAGCGATGA

CAACATGCTC

ATGCAGGTGC TGCGGAACAA CGAGATGCAG

GGAGAGGAGC

ATCAGCACCT

ATGTAATCAC

CGTGGGCAAG

TCAGAACCCA

ACAAACTGCA

GGATTGAGGG

AAATGAGTTG

GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA

GCTGTGAGGA

TGCTGCCACA

CTGAGCTTCC

ATCCAGCT1T

AGAACTTTGA

GACCAGGATT

ATATlGAGCA TCCATC17GA

TGAGACGGTC

TACTATTGCA

CCCTGGCTGG

GGTAACAGCC

AACGGGACCT

CCTrCCTCTG

CAAGAGCAGC

GGGCTGCCCT

TGGTGAATGC

TCCTGGATAC GCTGCATCGC CTCGGCATCC ACAGATCGCC TCCYFCATGG CCTACAGCAA CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC T-FCAGATGGA GAACTCCATG GGCACACTGC GGACTGGGCA GGGAGCAGAC AGTGAGCAAA ACAGTTGCTT Th2CAGCATGG GCCCAGGAAT ATGTCTCCGG TAAAACACCG GAGACTAATT TGGGGTGAAC TCACGCACAG CCAAGGACTC CCTGAGCCAG CCTGCTCCT-r CCCAGGAGTG( CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC GGTGCAATGG CTGAGTGCAC AAGTGAGTTG AGGACAATTT CTTGCATTrAA TAAAGGTTAA TI7ATGGCTCC CCTCACTGAT GGACAAGGAG CTTGCTGTAT ATGCAGTATT GAGCACTGTAC AGGAACTCAA AGACTCAAGT GGGAACGACT GAGCAGGGTG CTGTGGGTGA TATGGACAGC CACCACCTGT CCTGCGTC CTGCAGAAAA T-rGTCCTTAA CCCCTGTCTC CT7CTGGACC TCT-MrCCAC TIffCTTTCAG CGCCGACATG TTFGCCCAGAG CAAATGCCCC CAAGTGGAGT GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA TGCACGGTGG CAGAGATCTA CCTGGGGAAC TCTGGGCCAT CACCATCTCC AACAACT[CG CAT1TATCTCC ATGAACCTGT ACAGCAGCAT 284 TCTCCAGCTG CCAGGACGAG CGCATCATCG CAGCTGCCTC AACCCACTGG TGTACGTGAT CAGGGAGTGT OCCAGAAAGG GGGCTGCAGG GGACCTCCAT CTCCGTGGAA CGCCAGATTC CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GCCAAGGAGA CATCTATGCA CGACCTTGGG CCTGCCCTGC CCAAT[GC AGGGAGCATG CAAAATCACA ACAGCATTAC TG1TCTTATT 3AGGAGGCCT GGGGGCAGGG AGAGOAGTGA AAGACAACYI7 AGATCTCCAG GAGAACTGCC TTGCCCTGGG TrCTTTAAT CTATTCAGCT GCCCTGAGGG GTCCCTGATA ACAACCTGGA GTCTGTGCCA AAGAAGAATC CAATAAGCAC iOCAAGAGGG AAGAAAGAGA AGGAGCCATC GGGCACTGCC ACCACCAGAA AGAAGGGGGA GCCAGGTTCC CAGCCTGAGC TCCACCTCGG AGTTTTGTC CTTCCCTrGT CTCAATGTCA CCrrGCAAGG GGCTGGGCTG GCTCAACACC CATCTTTGTC CTCAGCGTCT CTGGCCGCAG CAGACCTGAT ACTGGCTCTT TGGGGAGACG CTGTTTCCTG ATGCTGGTGA

AGCTGTTCGA

AGCTCACCAA

CTTCTCCT-rG

GACCCTGAGG

GCCCACTCTT

ATCCAGCCCC

TCTGCCTGCA

CCTGGCCTGC

CTCTGCCGCG

GCATCGACCG

CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTTr CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCcJC'rGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTJTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAG;GGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CITCCAGATC AGCACCT'TCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC YUCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGcJAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG, AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCT1TC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GNCCTGCCCA A=T1GCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTrAT11TGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACUTAGA TCTCCAGGAG AACTGCCATC CAGCTTrfGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTr[ CTTFrAATCTA TTCAGCTAGA ACTTTGAAGG ACAA1TTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTfTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTI7CGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAAGTATTGC ACAACCACCT GTCCCTGCCT CAGTJ7CCCTC TYfCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA TGATCCTATC ACAACCTGAG AGTAGTTITT ACTCCATTTA CAGGTGAGGT CATTGTGGTT CAAGGACG11T AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCYFTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTT'rr

CTCYITTAAT

GGCCCCGGTT

ACTTGAGATT

GCCCCGTTTA

GCTGCAGAAA

CCTTCTGGAC

CGCCGACATG

CAAGTGGAGT

CCCTAGAGAA

CCTGGGGAAC

AACAACTI7CG

ACAGCAGCAT

GGGCCGGATG

AGCTCACCCA

TCATCAGCTA

GCCCCTGAGT

TTCAAGGAGA

GCTGGCTGCC

GGACGAGCGC

AAATTAACTC ACCCACCACA CGGCTTTFGAG GATAAGGAAG GAATGTGAAT CCTCCCATCA GTITAGTGCTG TTGGTGGATA CTGCAGAATA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA ACAGCCTGAG CTCCACCTCG GCT-rCTCCTT CAGTTTTTGT CCTTCCC'rro TGACCTGAGG CTCAATGTCA CCTJ7GCAAGG GCCCACTCTT

AGGCTCAAAG

CGGAAGC'ITC

TCCAGTGGAG

CCCAGGGGAG

GCCCTGGCTG

GGTAACAGCC

AACGGGACCT

GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG CATCTT-rGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCCATCCCTC ATCTGGGAAG TGT-rCACCAA CATGCTCCTG

GTGACCAACT

AAGGAGGTCA

CCTCAGATGA

TCAGGTGCAC

GTTGTCCTTA

TCTTTTCCAC

TTGCCCAGAG

GGTGCTGT[rC

TGCACGGTGG

TCTGGGCCAT

CATTATCTCC

CTGGTGAAAA

GGGGGTGTAC

CCACAACGTC

AATGTCGTGG

CCCTrGGGAG

AGGGTCCAAC

AGAACATGAG

TGGAGCGCGG

ACCCCTGTCT

TTTCTTTCAG

CAAATGCCCC

GTGCTGGCCA

CAGAGATCTA

CACCATCTCC

ATGAACCTGT

CCATGTCCAT

GCTGCTCCTG

ACCGCTTGTG

GCTTCCTGCT

GTCATCACCT

TCCAGACGGA

CTrCCAGATC

ATCATCGATG

TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG GAGGAGGGCC ACGGTGCTAG TCCTGGTJ7GT GCTGCTGCTA UTCATCATCT AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA TAATCACACA GATCGCCTCC UTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GOGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTFC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTrGGGAAA TGAGTGTTGA TGTCTCCGGT CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CAGCATI7ACT G117cTTATTT GCTGCCACAC CTGAGCCAGC GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAAT117CIT CC17GATAAC AACCTGGAGA CCAGGATr ATGGCTCCCC AAAACACCGG AGACTAATTC CTGCCCTGCC CACGCACAGC CAAGGACTCC AAAATCACAA CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG CTCCGTCCCT GCCCCAGCAA GACAACUTAG GAGTGCACAA GTGAGTTGTT GCCCTGGGTT GCATTrAATAA AGGTTAAGCC CTGAGGGGTC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA CCTGGAAGAT ATCAATGTTT CTGTCTGT[ GTGAGGACTC CGTGCCCACC ACGGCCTCTT CATGCTCAAT GTCACCTTGC AAGGGCCCAC TC'rrAACGGG ACCTTTGCCC AGAGCAAATG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTUCC TCTGGGTGCT GYFCGTGCTG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCITCTGGG CCATCACCAT T-rCGACTGGC TCTTITGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC GCATCTGITU CCTGATGCTG GTGAGCATCG ACCGCTACCT GOCCCTGGTG AAAACCATGT ATGTrCTCTC

TCAGCGCCGA

CCCCCAAGTG

GCCACCCTAG

TCTACCTGGG

CTCCAACAAC

CTGTACAGCA

CCATGGGCCG

285

GATGCGCGGC

CCCATGCTGG

GCTACCCATC

GAGTGTCATC

GAGATCCAGA

TGCCCTTCCA

GCGCATCATC

GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GATGTAATCA CACAGATCGC CTCCTTrCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC A317CAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AATTTrGTGTA AGGATTGAGG GTGAGGACTC CGTGCCCACC TCTTAACGGG ACC1TTGCCC CCCCCCrrCC TCTGGGTGCT TGCACAAGAG CAGCTGCACG CTGCGGGCTG CCCTTCTGGG CGCGTGGTGA ATGCCATTAT ACCGCTACCT GGCCCTGGTG CAGCTTGGTG ATCTGGGGGT TACAGCGATG AGGGCCACAA CCAACATGCT CCTGAATGTC CATGCAGGTG CTGCGGAACA CTAGTCCTGG TTGTGCTGCT CGCTGCATCG CCTCGGCATC CTCCTTCATG GCCTACAGCA AAGAAGTCTT GGGAOGTGTA AGAACTCCAT GGGCACACTG AGGGAGGAGA CAGTGAGCAA GCCCT-rCAAA GATGAGCTGT CGGTGGGGAC ATCAGGCTGC

AGGACTGGGC

GACAGTTGCT

ACGGCCTCTT

AGAGCAAATG

GTITCGTGCTG

GTGGCAGAGA

CCATCACCAT

CTCCATGAAC

AAAACCATGT

GTACGCTGCT

CGTCACGGCT

GTGGGCTTCC

ACGAGATGCA

GCTATTCATC

CTCTCCAGCT

ACAGCTGCCT

CCAGGGAGTG

CGGACCTCCA

AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG T ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGT-rC

TCAGCGCCGA

CCCCCAAGTG

GCCACCCTAG

TCTACCTGGG

CTCCAACAAC

CTGTACAGCA

CCATGGGCCG

CCTGAGCTCA

*TGTGTCATCA

TGCTGCCCCT

GAAGTTCAAG

ATCTGCTGGC

GCCAGGACGA

CAACCCACTG

TGCCAGAAAG

TCTCCGTGGA

CATGCTCAAT GTCACCTrGC AAGGGCCCAC GAGTGGCTGG GCTGGCTCAA CACCATCCAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC GAACCTGGCC GCAGCAGACC TGATCCTGGC TTCGACTGGC TCT-rTGGGGA GACGCTCTGC GCATCTGTTT CCTGATGCTG GTGAGCATCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CCCATGCTGG TGTTCCGGAC CATGAAGGAG GCTACCCATC CCTCATCTGG GAAGTGTTCA GAGTGTCATC ACCTTCTGCA CGATGCAGAT GAGATCCAGA CGGAGAGGAG GGCCACGGTG TGCCC1TCCA GATCAGCACC TITCCTGGATA GCGCATCATC GATGTAATCA CACAGATCGC GTGTACGTGA TCGTGGGCAA GCGCTTCCGA GGGGCTGCAG GTCAGAACCC ATTCAGATGG ACGCCAGATT CACAAACTGC AGGACTGGGC ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTr GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA GTGGGOACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT ATATTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACC'TI17

CCCAGCACAG

GCCCTFFCAAA

CGGTGGTGAC

CTCCGGAGAA

CCAGCACAGA

GAGCTCTTCA

CAGAGGGCT-r GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCC1TCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTYI7 GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTJ7CA AAAAAAAATG YTrTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTTF TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC T-rGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTUCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG T-rACGCGAGG CAAAPI7TATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTITT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC T-rCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTr CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCYJTCAAAG ATGAGCTGTr CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGOCAGOCA GCGGGGAGAA GTTFCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC C'r[CCGGAGG GAGG CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTI700GAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAAT-rCCT GCCCTGCCCA ATTI'rGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCA~fACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCT-rCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCT1TGGT GCAATGGCTG AGTGCACAAG TGAGTTrGTTG CCCTGGGT CTT-rAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTrCTT GCATTAATAA AGGYI7AAGCC CTGAGGGGTC CCTGATAACA ACCTGOAGAC CAGGATI'A TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TrGAGCACT-r GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC 286

ATCTTGAAGG

GACGGTCGAG

TAACTATTGC

AAGGCAGTAA

GACGTAACTG

CAGTATTGGG

CCACCTGTCA

GTCTTCAAAG

TGCTGAGACC

TGTCTCAGCA

GAAGAGTGTG

AAATGAATAT

AGGGCTAGAA

AAAACCTGAG

AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGG17CCA GCTCAACCAA ACAACCACCT GTCCCTGCCT CAGTTCCCTr TTATGTAACA TGAAGTCGTT GTGAGGGTTA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATrACGCA GGATATGTTr ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTr TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT TCTGAYFTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAO GGACTGTTCC ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT TITATTAGCTG GTJ7GGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT

CTAGAAGCTG

CTGGAATCTG GAGAGCTAGA GGAGGGCTGG AATCTGGAGA GAACCTGGAG GGCTAGAACC GGGCTAGAAC CTGGAAGGGC CCTGGCAAGC TAGAACCTGG GGCAAAGAGC CCATAAATCC CCTCCYJTACC CCCAACCCAC GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA TGGCAGGTTA GAACCTAGAA GGGCTAGAAC TAGAACCTGT AGAGCTAGAA CATGGAGAGC AGGGAATGAA CCTGGAGGGC TAGAACCTGG TGACCAATCC AACTCTGAAT TTTAAAGCAA TCYTTrTTCC CACCACCCAC TCTCCTCTGC AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATr AGTATTAGAA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGYFTTGT CACACAGGGC CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GYFGTAAACA GGAAGCATTT ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT AAATGATAGA CCGTCAATAA T-rTGTTAAAT GCTJTAAA ATGAATGCTT ACATCTGTAA TCCtCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG CTGGAGAGCC AGAACCTGGA TAGAACCCGG CAGGCTAGAA AGAATGAGAA AAATTTACAT AAGCGTGAAA AAAAAGATTC CTCAGTAAGT ATCTGGAGGA TGAAGTCAAA CTGTGCCACA AGTCATTCAG CACCAGAGCA GTGGGGATCC ACACCTGGTC ATGCCCTGAT AAAGAACATC CACATCCAAA CGAGAAAATC GCAAAAAAAA AAAAAAAAA TAAGCCGGGT GCAGTGCCTC CAGGAGTTCG AGACCAACCT GGCATGGTGG CAGGCACCTG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC TGTGCGTGCT CGTTGCATCC TTrGCAAGTG TCCAAACCCT ACCTT-rTCCA GGTGT-rAATT ACCTCCCACT TCA'ITTCCTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC AAACCCAGGT GCCGGGTGT[ GCAGAGTGGC TGAAAGCTGG ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ATAGACCACA GCTTJ7CCACA CCCYI7CCTAG ACAGGGGTCA GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC GAAACUTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA ACACATGACC TFTCTCCTCT AAATCAGCCC CCCATCTCTG GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA TGCTI7GATf TTCACTGTAC TTAGGTCAGT TTGCAGTTAT GTAGACTGTC AGCTCCTAGC CATTrGTATAC CTAGCACCGC GAATTTTCTT TCTATGAGCC CAGGAGGGCC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC GATCCCAGCT GTGCTTAGGG GT-rCCTGCAA TTTACCAACT CAGCTFfTrTG TTTTAGTGTG CCAACTGAAT TAGGGGAGCT GGGCTTCTGG GATGTGGCAG ATCCGTGGCT ACATTFCATGC ACACACCCGC ACTCACACAC TTGGACATGC CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGGACTGAGA CAAGTCACCA CCAACCCATC CATGCCTGCC CCCCTGGATG GGAGTGATGT GGCCCTFGGG AAAAAAGGCC C1TTTCAACTA CT-rGTAATI'G

AAAGTCCCTC

CTGGACCCAA

CAGTTCCAGC

CCTTFGCAGG

ACTAGGCATG

GAAGCTAATG

CCAGGGCCTA

ACCCTGTYI7A

CCCCATGTTC

rAAGTGACTG

TGTGTGGGAG

AGAATGCGTG

GTGTGGCCTC

GTTCGTGAGG

~GGGGAGGTG

AGGAACCATG

AGCAGAGGGA

GTAAGCCAAG

AAGACCCTGT

CCAGCCCTAT

CTTTAACAGT

AGATGGAAGC

TCAGGTTrFAC

GGCTAACTGG

ATCGATATTC

GTTCTGCTCA

TATGCTCTCA

AGCAATGTCT

CACGTGACAA

TAT17rGGCAA

ACTCACATCC

ACTCCGTGCC

GGCAGACACC

GTGATGTTAA

ATGTTCTGTG

ATCTATCCCA

CCCGAAGGGA

CTCCATCACA

GGGGTCGCAT

TCCAGTCTAA

CATGACACCT

CCTCTAAACT

TCCTTGCTTC

ACACCAAGCG

CCCTCAGTGT

CAGGACCTTT

GGCY[CTCCA

ACGTCCAGTG

TCCCCAGCCC

CACTCTGAGT

CACCACGGCC

CTGGAGAACT

GCCCAAAGAC

GTCTAGAGGA

GATGAACTTrG

AGTCAGGGAC

CTGTGCCATC

CCAAATGTTC

TCTTTCAGGT

CCCTGGAAAG

AAAACCTCTC

AGAGGGGCTC

TCAGCAGTCT

TAACCATCTTf

TCTCCCTGGA

G3AGTCAAAGG

CTCAACTCTC

AGGTGTCCAA

CCATTTCTCC

TTCTTCTCTG

AGATATCAAT

GATTCCTCAG

ATGCCCCGGA

GTCCCTGTTG

GCCCTGCTGG

TTCAGCCCAG

GT117CTGTCT

TJTCACTAGTT

CAACAGTTGA

GAATCTTGGG

AGGGAGGAGA AGGGCACATT CCTGGTTG~r ATATGTTTCT GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGOATCAG ACAGCAATGT GCCAGATTGC CTrGGAAACA AAATATCTCC AACACATGGC TGACATrTGG TGGOAGATCA GAACACCCTA AAGAGAGAAT T-rAAGGGGAG GGGGAGGAGG ACCTGAGCCA GiAGTAGAAGC AGAGGATAGGJ GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC 287

AGCAGGCATC

ACTGTCTTGC

AAGATGATAG

GGGTTGGACC

TCATGGGTCA

GGAAGATTCA

GTGGCAAGT[

GCAATGCAAA

TTTCTGATGA

TGAGAAAmT

ACTCTCCAAG

AAGGGACTAC

AGAATTCAGA

AAGGCTAGGA

GGTTCCCCCC

AGGCCAAGAA

TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT ATAAGCAGCA TCTGGTGCTA TACMTGGTC TCTAGTGAGT CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA CCAGGGGAAG TCTTACCT-rC AGAGGACTCT GGAAAGGAGG GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC AGATGCTGCA AAGATGUTAT GACCTAGCCT CAGAAATCAC TGCCACCATr AGTAAGAAGT CCAGCCCACG GAATATCAAG TAATTCGGGG GGCATATGAA 11TATACCATC ACTGTAGTJ7C CTTAAGACTC CGCTTACTCC CTCACTCAAC AACATACCAA CAGCTTCCCC CCTrCYI7GTC CGGTCAAAAT CACCAGCCCC CTCTCCAAGT GCCACAG1TG TCAGGAGTCA AGAGCTCAGC ACAGAGCAGA TCTGGCTCCA GGATGCCAGC TGATCAGTAA TCTCTCCCGT CAGAAAGAGC CCC'ITJCCT TCTGGGTTGT GCTTTGGACT

CTCTTGCTAC

AGTTCTGTGC

GCTTCTTrATC

CTGTGTCCCA

GGCAGGGCAC

CGCTCAAAAA

TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT AGCCACCACA CACCACAGGG ATC'FFTTrAG AGGGGCAAAG CCTCACTTCC TTAGCACCCA TTCCCACCTC TCCTGTCCAA CATCTAGTGT CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CTFTCAAGACC CAGCTCTAGA GTCACCTCCA CAAGCCCCCT GCTCCCTCCA GGGCACCCTC GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG ACATTTAAAG GATAGAAGCA TTGA1TTGTG

CCCCTTGGCT

TAGCTCATGA

ATGGGGTTGA

CTGCAAGTTT

GGCCT'TGGTT

CACTTITCAAG

TTCCAAGTAA

ACACCATCCC

TTGAAATGAA

AGCATACTTC

GTGAAGACCA

CACTTTCCAG

CACT-rGTCCT ACCCCTrACC

CACCCTCTGG

CACTCAGGGC

GGTCCCCCAG

CAGCTGCTCC TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA GACTCGTAGT TCAGCTCTTC TCTCTCACCC ACAGCACAGG TTTCAGTGTG TCTCGCATCC

CTCCATGAGC

GCACTGGGAA

ACTCTTCAAC

GAAAAAAGAA ATGCAAAGCG A'ITCAGGATG AGAGCAATAC CCTACTCCAA AGAGAGATCA AGCAA1TrGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT A~rGAGCCTA TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA

CTGACTATCA

AATGCCCAAT

TTGAATGTTG

AGAAGGCAAC

TGGCTGTCCA

GCCCTATGGT

ACGGTGGTGT

GTGCAGTGCG

CTGCCATGTT

GTGGACCTTC

GAGTCCTGCC

CAACAGCCAT

ATAGAAGCTC

AGCCCCATGG

CTGTGAGTCT

TGGAGTTTAC

TGGGGCATTT

ACAGGTGAGG

TCATTGTGGT TCAAGGACGT TAAGTAACT-r CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA CTCACCCACC ACACGGCTTTl- GAGAGGCTCA AAGTTGACCA ACTCCCYI7GG GAGGGCCCCG GYI7GATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT GTCCTTCCCT TGTGACCGGT GAGGGGTAAC AGCCTCTTTC CACTTrCTrT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTFAACGGGA CCTTrGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTITCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TOOCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTrTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCYTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCT-rCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCT-rG GGAGGTGTAC CAGGOAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GOATTGAGGG ACAGITGCTI TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTFCTTATT TOCTOCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCYUCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TFUGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAATTT CTTrGCATTrAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATr GAOCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTG~rCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATI'GCA CACCACCTGT CCTGCCTC TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGGYI' CAAGGACGT-r AAGTAAC'TC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC 288 CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA OCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTTTT CTCTTTTFAAT AAATTAACTC ACCCACCACA CGGCTTTGAG AGGCTCAAAG GTGACCAACT CCCT-rGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTJTAGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA ACCCCTGTCT CC'ITCTGGAC TCTTTTCCAC TTTCTT-FCAG CGCCGACATG

TITGCCCAGAG

GGTGCTGTTC

TGCACGGTGG

TCTGGGCCAT

CATTATCTCC

CTGGTGAAAA

GGGGGTGTAC

CCACAACGTC

AATGTCGTGG

GGAACAACGA

GCTGCTGCTA

GGCATCCTCT

CAAATGCCCC

GTGCTGGCCA

CAGAGATCTA

CACCATCTCC

ATGAACCTGT

CCATGTCCAT

GCTGCTCCTG

ACCGCYTGTG

GC'I17CCTGCT

CAAGTGGAGT

CCCTAGAGAA

CCTGGGGAAC

AACAACTTCG

ACAGCAGCAT

GGGCCGGATG

AGCTCACCCA

TCATCAGCTA

GCCCCTGAGT

CAGTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC CTCAATGTCA CC17GCAAGG GCCCACTCTT AACGGGACCT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CC11TCCTCTG CATCTTrTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT ACTGGCTCUT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CTGTTICCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TrFGGTGATCT TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCCATCCCTC ATCTGGGAAG TGT-FCACCAA CATGCTCCTG GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT GATGCAGAAG T-TCAAGGAGA TTCATCATCT GCTGGCTGCC CCAGCTGCCA GGACGAGCGC ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGAYUCACA AACTGCAGGA CTGGGCAGGG GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GT-rGCTTTTC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AGACTAAT7C CTGCCCTGCC CAATTTTrCGA GGGAGGATOG CTGTGAGGAT GGGGTGAACT CAAGGACTCC AAAATCACAA CAGGATTACT GTTCTTMTTF GCTGCCACAC CTGAGCCAGC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GTGAGTTGT[ GCCCTGGGTT TCTTTAATCT ATCAGCTAGA ACTTI'GAAGG ACAATTTC17 AGG11TAAGCC CTGAGGGGTC CCTI'GATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TGTAGGCA ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC

AGTCYJTGGGA

CTCCATGGGC

AGCAGACAGT

AGCATGGGCC

AAAACACCGG

CACGCACAGC

CTGCTCC11TC

CTCCGTCCCT

GAGTGCACAA

GCATTAATAA

TCACTGATGG

TATTGAGCAC

CGTGCCCACC

ACGGCCTCYI7 TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG GTTCGTGCTG GCCACCCTAG GTGGCAGAGA TCTACCTGGG

CCATCACCAT

CTCCATGAAC

AAAACCATGT

GTACGCTGCT

CGTCACCGCT

GTGGGCTTCC

ACGAGATGCA

GCTATTCATC

CTCTCCAGCT

ACAGCTGCCT

CTCCAACAAC

CTGTACAGCA

CCATGGGCCG

CCTGAGCTCA

TGTGTCATCA

TGCTGCCCCT

AGAACATCTT TGTCCTCAGC GTCTITCTGCC GAACCTGGCC GCAGCAGACC TGATCCTGGC TTCGACTGGC TC1TGGGGA GACGCTCTGC GCATCTGTTT CCTGATGCTG GTGAGCATCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CCCATGCTGG TG'ITCCGGAC CATGAAGGAG GCTACCCATC CCTCATCTGG GAAGTGTTCA GAGTGTCATC ACCTITCTGCA CGATGCAGAT TCTTAACGGG ACCTTrGCCC CCCCCC'rCC TCTGGGTGCT TGCACAAGAG CAGCTGCACG CTOCGGGCTG CCCTTCTGGG CGCGTGGTGA ATGCCATTAT ACCGCTACCT GGCCCTGGTG CAGCTTGGTG ATCTGGGGGT TACAGCGATG AGGGCCACAA CCAACATGCT CCTGAATGTC CATGCAGGTG CTGCGGAACA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTrCCTGGATA CGCTGCATCG GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTrCATG CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT

TTGTGCTGCT

CCTCGGCATC

GCCTACAGCA

GGGAGGTGTA

GGGCACACTG

CAGTGAGCAA

CCTGGAAGAT

CCAGGGAGTG TGCCAGAAAG GOGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA ACGCCAGCAG GGCTGCTGTG AATGTGTA AGGATTGAGG GACAGTTGCT T ATGT7CTCTC ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTT-7GCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCC17CC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGYT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGT-rcCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GICTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTrCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCC'11CATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT 289 CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATT-rGTGTA AGGATTGAGG GACAGTTGCT T GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGOGAG GGAGGGCAGG CAGGGGGAG AAGTT-rCCCT GTGGTCGTGG GGAGTT GCCCTrCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTrTCCCTG TGGTCGTGGG GAGTT GAGCTCTTCA ATATTfUAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG AGGAAACTCC AGATTAAGGA GCCCCAATGT CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC GTAGGCTTGT TATGAATCAA GTCACAGGGA TGTCTCTTCC CCAGATCCAC TGGGCCCACT AAAAAAAATG TTTTGAAAGT CCCTGCCCTT GCAGATAGT7

GCCATACATC

AGCTTCTGCC

ACCTGGCCAC

TAACCACCTC

T-rCCCAGGCC

CCTACGCAAA

GCGAAGGTGG

GCTGGAGGCG

CCCGCCGCCA

CAGGCTGCCC

GGCAGGGGCT

AGTAAGTCTT TGAGCAAAAC TCCGAAGAAA CGGCCGCGTG ACTGTCGCCC 17GGGAGCCG CCTCTGTTTA CACCTTCCGC AAGAAGATAA ATAATGATAA ACTTTGTGGT CAGCCGGGAG CATGGAAATC TI'CCAAGAGC CCGCAGCCTT CCCGGCCCCA GGCAGCCTGT CCATAGACCT CTGTCCCCAA GGTTGAACAG CCAGGTGCAC AGATGAGTCA TACAGCCAGT TCACAGCCAA GCCAGGGCTA CTGTCTCCAT GATGATGGGA TCAGGCUTGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT C'I7ATCTGTT CTCTTCTGAA GGAAGGGTTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT TGAGAAAGCC AGCCTGAGCC 17GACATGGG TCTCAGGGGA GCGCAAACAC CCGTACCCAG TACGTGGCAT GACAAAGAAA TCCCAGGACT GTAAACGCCC ACTGTTTACA TCCAAAACTC GAAATAAATG TTACGCGAGG CAAATTTATT GGACGTTTTT GCCGTCCCAC GACTCCAACG CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT

CTGGCAAGTC

ACCACACAGC

GCGCCAGGCC

TTGCTGGTTT

CTGGCCCTCC

TAAGGCTTCA

GTAAAGTGCT

AGAAACCTCC

GAAACAGGAC

CCGCCTGCCC

AGACACAAAA

CACATGGGGC

GGCAGCCGGG

AGAGCGGAGA

GCAGAGCTCA

AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CT-rCCGGAGG GAGG (FRAG. NO:2275) (SEQ. ID NO:3018) GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGJAGGCTC CATAGGGGAT AAAGCACAGA CACACCTrTT

CAGAGGGCTT

AGATTAAGGA

AGGGCCTTCA

TGATCTGAGA

TATGAATCAA

CCAGATCCAC

TITFGAAAGT

AGTAAGTCTT

TCCGAAGAAA

ACTGTCGCCC

GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC GCCCCAATGT GGTTGAACAG CCAGGjTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG

CTCAAGAGCC

CTCTGTTTCC

GTCACAGGGA

TGGGCCCACT

CCCTGCCCT17

TGAGCAAAAC

CGGCCGCGTG

TFGGGAGCCG

TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC CTGTCTCCAT GATGATGGGA TCAGGCTTGA UTGCTGGTTT GTAGGCTTGT AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTr TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTfCTGCC TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGYITTA CACC17CCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTFT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCT-r CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG-3' (FRAG.NO:2275) (SEQ.ID NO:2461) GCCCTITCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT -3' (FRAG. NO:2275) (SEQ. ID NO:2460) GCCCTrCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA 6 0 CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCT-r GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTI7CCCT GTGGTCGTGG GGAGTT-3' (FRAG.NO:2275)(SEQ.

ID NO:2459) ATGTTCTCTC CCTGOAAGAT ATCAATGYJT CTGTCTG'rrC GTGAGGACTC CGTGCCCACC ACGGCCTC1T TCAGCGCCGA CATGCTCAAT GTCACCT-rGC AAGGGCCCAC TCT-rAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTrCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATC'rr TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA 290 TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TC1TTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTrr CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTfCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTAT[CATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TrCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCT7CATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGA'IT CACAAACTGC AGGACTGGGC AGOGAGGAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AAUTTGTGTA AGGATTGAGG GACAGYJ7GCT T (FRAG. NO:2275) (SEQ. ID NO:2458) ATGTITCTCTC CCTGGAAGAT ATCAATGT CTGTCTGT17 GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCT[AACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTrCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTITCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTIT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTrCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATrCATC ATCTGCTGGC TGCCCTJTCCA GATCAGCACC U-CCTGGATA CGCTGCATCG CGTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCIT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATr CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AAI'TGTGTA AGGATTGAGG GACAGTTGCT T (FRAG. NO:2275) (SEQ. ID NO:2457) TGATCCTATC ACAACCTGAG AGTAGfTrM ACTCCAmTA CAGGTGAGGT CATTGTGGTT CAAGGACGTT AAGTAACTTC CCCAGCTCAC CTGCAAAGTC CCCACCCTCC ACGGAAATAC GATGCCACAG ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCTTTGCT ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TCTGGAATGA TATCATT-rTT CTCTI'TTAAT AAATTAACTC GTGACCAACT CCCTrGGGAG GGCCCCGGTT GATAAGGAAG AAGGAGGTCA AGGGTCCAAC ACTTGAGA1T GT-rAGTGCTG

GCCAGACTGG

CGGCTTTGAG

CCTCCCATCA

CTGCAGAATA

CTCTGTAAGA

GCTTCTCCTT

TGACCTGAGG

AATCTCCAGG

AGGCTCAAAG

CGGAAGCTTC

TCCAGTGGAG

CCCAGGGGAG

GCCCTGGCTG

GGTAACAGCC

GCCCACTCTT AACGGGACCT ATCCAGCCCC ccTrccTcTG TCTGCCTGCA CAAGAGCAGC CCTGGCCTGC GGGCTGCCCT CTCTGCCGCG TGGTGAATGC GCATCGACCG CTACCTGGCC GCTCTACAGC YITGGTGATCT AAGGAGTACA GCGATGAOGG TGT'rCACCAA CATGCTCCTG GCAGATCATG CAGGTGCTGC ACGGTGCTAG TCCTGGTTGT TGGATACGCT GCATCGCCTC GATCGCCTCC TTCATGGCCT

CCTCAGATGA

TCAGGTGCAC

GTTGTCCTTA

TC1TTTTCCAC

TTGCCCAGAG

GGTGCTGTTC

TGCACGGTGG

TCTGGGCCAT

CATTATCTCC

CTGGTGAAAA

GGGGGTGTAC

AGAACATGAG

TGGAGCGCGG

ACCCCTGTCT

TTITCTTTCAG

CAAATGCCCC

GTGiCTGGCCA

CAGAGATCTA

CACCATCTCC

ATGAACCTGT

GCCCCGYI1TA GATCCAAGGA GCTGCAGAAA ACAGCCTGAG CCTTCTGGAC CAGIT=GT CGCCGACATG CTCAATGTCA CAAGTGGAGT GGCTGGGCTG CCCTAGAGAA CATCTTTGTC CCTGGOGAAC CTGGCCGCAG AACAACTrCG ACTGGCTCTT ACAGCAGCAT CTGTTITCCTG

GACTATCTGG

GATAGAAGGT

TGGTCTCCAA

ACCCACCACA

GAATGTGAAT

TTGGTOGATA

TCAGAGGGGG

CTCCACCTCG

CCTrCCCT-rG

CCTTGCAAGG

GGTCAACACC

CTCAGCGTCT

CAGACCTGAT

TGGGGAGACG

ATGCTGGTGA

CCATGTCCAT GGGCCGGATG GCTGCTCCTG AGCTCACCCA CCACAACGTC ACCGCTTGTG TCATCAGCTA AATGTCGTGG GCU-CCTGCT GCCCCTGAGT GGAACAACGA GATGCAGAAG TTCAAGGAGA GCTGCTGCTA TTCATCATCT GCTGGCTGCC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ACAGCAACAG CTGCCTCAAC CCACTGGTGT CGCGGCGTGC GCTGGGCCAA TGCTGGTGTT CCGGACCATG CCCATCCCTC ATCTGGGAAG GTCATCACCT TCTGCACGAT TCCAGACGGA GAGGAGGGCC C'I1CCAGATC AGCACCTTCC ATCATCGATG TAATCACACA ACGTGATCGT GGGCAAGCGC 'rrCCGAAAGA AGTCTrGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATrC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTrTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTrGGGAAA TGAGTGTI7GA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATrACT GYI7CTATTT GCTGCCACAC CTGAGCCAGC CTGCTCC1TC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTI'CCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGUTGTT GCCCTGGGTT TCMTAATCT ATCAGCTAGA ACTTTGAAGG ACAATCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CC'rrGATAAC AACCTGGAGA CCAGGATT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC 291 TGTATATCAG TATTGAGCAC TGTAGGCA (FRAG. NO:2275) (SEQ. ID NO:2456) CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTrG CCCTGGCTGG TTGTCCTTAA CCCCTGTCTC CT-rCTGGACC AGTTTIGTC CTfCCCTFGT GACCCTGAGG GGTAACAGCC TC'rrTrCCAC TTfCTfTCAG CGCCGACATG CTCAATGTCA CCTrGCAAGG GCCCACTCTT AACGGGACCT UTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GJTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGGA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTrTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TrCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC C'FrCCAGATC AGCACC'rrCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATU TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATJTCCT GNCCTGCCCA ATiTrO7CAGO GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCC'FFCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTJTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT C=TAATCTA TTCAGCTAGA ACTTTGAAGG ACAATITrCT GCAT-FAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGT-rCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGGAGA AGGGGGAGAC CAAGGT-rCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TfCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA -3' (FRAG. NO:2275) (SEQ. ID NO:2455) AAATGATAGA CCGTCAATAA TTTG'rrAAAT GCTT-rTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG AAGATTACGC CATTGTACTC AAAAAATTAC GCTTCAAACA TCTCAGAGAG GAAAGCTCCT TGTGCGTGCT CGTTGCATCC ACCTTTTCCA GGTGTTAATT TTTGAATTCC CTGAACTGAC AAACCCAGGT GCCGGGTGTT ACACACACAC ACCCACATAC ATAGACCACA GCTTTCCACA GGAATGGAAA GAGGGGGGAI TGCGCCTTGT TTACCTCCTC GAAACTTGAA GGGCGGTCAG GGGGCACAGA GGAGGCCCTG CTGGAAATAC TCAGATGTGT GTGCTCCAGT CCAGACCCCT CCCCACCTGC CTGGAATTCT ACACATGACC TfrTCTCCTCT GCCTCGCCCC TGTCCTCACC CCTCTGGAAT CCAGTCTCTC CACTCTACCC CCACTGCAGT CCAACCTGAC TGAGATATCC TCTCATCAAT AATCCACTCC TGCTTGAT TJTCACTGTAC GTAGACTGTC AGCTCCTAGC AGTCAGGGAC TCAGCAGTCT CTGTGCCATC TAACCATC117 CCAAATGTTC TCTCCCTGGA TC1TTCAGGT GAGTCAAAGG CCCTGGAAAG CTCAACTCTC GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA

CATGATCTCT

AGGTCTTCCT

TTFGCAAGTG

ACCTCCCACT

CGTTGTCTGA

GCAGAGTGGC

CCACACATGC

CACCACTGTT GAATTTTCTT TCTATGAGCC TTCCCTCTGC AAACTCCCTG CCTIGAAGGT TCCAAACCCT GATCCCAGCT GTGCTTAGGG TCATTTCCTG TTTACCAACT CAGCTTTTrG TCTCCACCTC CCAACTGAAT TAGGGGAGCT TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACACACACAC ACACACCCGC ACTCACACAC

CAGGAGGGCC

TCAGAAGGAC

GTUCCTGCAA

TTTTAGTGTG

GGGCTTCTGG

ACATTCATGC

TTGGACATGC

CCCTJTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT -TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT AGCAAGGGTC GGGAATGGAA GGCCCITGGG AAAAAAGGCC C1TTCAACTA

GGCTGAGAAC

CTGTCTCCCT

CCTCTGAGCT

CCAAAGAACC

AAATCAGCCC

CCATCCATGT

AGTCTCCATC

CCTGACTITCC

TCCTGCACCA

CCTCACAGGC

TfTAGGTCAGT

CATTGTATAC

CCATTCTCC

TTCTTCTCTG

AGATATCAAT

GA'rrCCTCAG

ATGCCCCGGA

TTGACAGjCAC C'ITGTAATTG GTAAGCCAAG CCCGAAGGGA TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT TCCCCYT-AA CAGTTCCAGC CT1TAACAGT TCCAGTCTAA CCCATCTCTG CCTGCAGG AGATGGAAGC CATGACACCT CCAATCAAGC ACTAGGCATG TCAGGTTrAC CCTCTAAACT ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC TGAGCAGCAG CCAGGGCCTA ATCGATAT-fC ACACCAAGCG TCATCCCTCC ACCCTGTTTA G'ITCTGCTCA CCCTCAGTGT GCGTTTGGGA CCCCATGT7C TATGCTCTCA CAGGACCYTT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCT1CTCCA CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG GCCCTGCTGG AGAATGCGTG TAT1-rGGCAA TCCCCAGCCC TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT GT~rCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC 292 AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATG'rrTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTr AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC C11TGGAAACA AAATATCTCC AACACATGGC TGACA17TGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TITAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTrCCAA TTCCGCACTC AGCAGGCATC TTITCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTFGGCT ACTGTCYI7GC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTr TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGA11TCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTflCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TrGAGTATCC TCACATGGCG GCTCACATCC TrCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATI7 AGTAAGAAGT GAATATCAAG TAATTCGGGG ITATACCATC ACTGTAGTTC CGCTTACTCC CTCACTCAAC AACATACCAA CAGCTJTCCCC CCTTCTTGTC CGGTCAAAAT CACCAGCCCC CTCTCCAAGT GCCACAGTTG TCAGGAGTCA AGAGCTCAGC ACAGAGGAGA TCTGGCTCCA GGATGCCAGC TGATCAGTAA TCTCTCCCGT CAGAAAGAGC CCCTITJCCT TCTGGGTTGT GCTTTGGACT

CCAGCCCACG

GGCATATGAA

CTTfAAGACTC

CTCTTGCTAC

AGTTCTGTGC

GCTTCTTATC

CTGTGTCCCA

GGCAGGGCAC

CGCTCAAAAA

CAGCTGCTCC

TCCAGGAGAA GAGGAAGCAG AGCCACCACA CACCACAGGG AGGGGCAAAG CCTCACTTCC TTCCCACCTC TCCTGTCCAA CTCTGCTCAG GCTGTTCCCC C'FrCAAGACC CAGCTCTAGA CAACCCCCCT GCTCCCTCCA ATTCCTCCT7 ATCYTI1AG

TTAGCACCCA

CATCTAGTGT

CTGCCTGGTC

GTCACCTCCA

GGGCACCCTC

TTGAAATGAA

AGCATACTTC

GTGAAGACCA

CACTTTCCAG

CACTrGTCCT

ACCCCTTACC

CACCCTCTGG

GGGCCGGGTG GTGTCUTCTT TGTGTTCTTG CACTCAGGGC ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TAGAAGCAAA CGGACTFJC CTGGGAAATC CCAGAGGTGA GACTCGTAGT TCAGCTCUTC CTCCATGAGC TCTCTCACCC ACAGCACAGG GCACTGGGAA TT-FCAGTGTG TCTCGCATCC GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC AGAGAGATCA AGCAATJTTGC CCAAGACCAC ACAGCTAGGA CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTTT TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA

ACTCTTCAAC

CCTACTCCAA

GTGGAACTCA

AAAGGTGCCT

GTCACCAACA

ATTGAGCCTA

GTGGTTTTAA

CTGACTATCA GTGGACCTTC AATGCCCAAT GAGTCCTGCC TTGAATGTTG CAACAGCCAT AGAAGGCAAC ATAGAAGCTC TGGCTGTCCA AGCCCCATGC GCCCTATGGT CTGTGAGTCT ACGGTGGTGT TGGAGTTTAC GTGCAGTGCG TGGGGCATTT CTGCCATGTT ACAGGTGAGG TCATI7GTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCT-TT AATAAATTAA CTCACCCACC ACACGGCYI7T GAGAGGCTCA AAGTTGACCA ACTCCCTTFGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTFGAG ATTG~rAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTUCTGG ACCAGTTfTTT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTrC CACTTTCTTT CAGCGCCGAC ATGCTCAATG TCACcTTrGCA AGGGCCCACT CTrFAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCYJ7CCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCT7T GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATrATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT G~rCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTr GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGYI7CAC CAACATGCTC CTGAATGTCG TGGGCYI7CCT GCTGCCCCTG AGTGTCATCA CCYTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCC~rCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCYJ7G GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA YITCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATGTGTAA GGATTGAGGG ACAGTTGCTT T-rCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTCTTTAAT CTATTCAGCT AGAACTrGA AGGACAATTT CTrGCArrAA TAAAGGTTAA 293

CAAAATCACA

GAGGAGGCCT

AAGACAACTT

11'GCCCTGGG

GCCCTGAGGG

GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC -3 (FRAG. NO:2275) (SEQ. ID NO:2454) CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA rJTGAGGGACA GTTGCTITTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTArFJ7GC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTfAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TrCAGCTAGA ACTTI7GAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA T-rGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTr TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTAC11TAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTr CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATITrGGAG AGAAGGCCAT GTCTTCAAAG TCTGATGT GATGAGGCAG AGGAAGATAT FUCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT FFATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTITGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTITAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCYTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATfTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC ITAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGACCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA (FRAG. NO:2275) (SEQ. ID NO:2453) GAGCTCTI7CA ATAYTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCUTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA U-GCTGGTT-r GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTYF CTCTTCTGAA GGAAGGGTUT TAAGGCTTCA AAAAAAAATG TTTTGAAAGT CCCTGCCCY[ TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTrCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTrTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATrA'IT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGT=r~ GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC T-rCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGOAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGY[F CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CT1'CCGGAGG GAGG-3' (FRAG..NO:2275) (SEQ.ID NO:2452) GCCCYI7CAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG 294 CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTrTCCCTG TGGTCGTGGG GAGTT -3' (FRAG.NO:2275) (SEQ.ID NO:2451) GCCCTUCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCUTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT-31 (FRAG.NO:2275) (SEQ. ID NO:2450) ATGTTCTCTC CCTGGAAGAT ATCAATGT[ CTGTCTGTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTT

TCAGCGCCGA

CCCCCAAGTG

GCCACCCTAG

TCTACCTGGG

CTCCAACAAC

CTGTACAGCA

CCATGGGCCG

CCTGAGCTCA

TGTGTCATCA

TGCTGCCCCT

GAAGTTCAAG

ATCTGCTGGC

GCCAGGACGA

CAACCCACTG

TGCCAGAAAG

TCTCCGTGGA

CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCUTAACGGG ACCTfrTGCCC AGAGCAAATG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC GCATCTGTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC TGCCCTfrCCA GATCAGCACC T-rCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA ACGCCAGATf CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AAYIGTGTA AGGATTGAGG GACAGTTfGCT T (FRAG. NO:2275) (SEQ. ID NO:2449) ATGTTCTCTC CCTGGAAGAT ATCAATGT CTGTCTGTT-r GTGAGGACTC CGTGCCCACC ACGGCCTCTT

TCAGCGCCGA

CCCCCAAGTG

GCCACCCTAG

TCTACCTGGG

CTCCAACAAC

CTGTACAGCA

CCATGGGCCG

CCTGAGCTCA

TGTGTCATCA

TGCTGCCCCT

GAAGTTCAAG

ATCTGCTGGC

GCCAGGACGA

CAACCCACTG

TGCCAGAAAG

TCTCCGTGGA

CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTI'TGCCC AGAGCAAATG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCT"TCC TCTGGGTGCT GTTCGTGCTG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCC'rrCTGGG CCATCACCAT TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC GCATCTGTT"T CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT GCTACCCATC CCTCATCTGG GAAGTGTITCA CCAACATGCT CCTGAATGTC GTGGGCTTCC GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTrCATG GCCTACAGCA ACAGCTGCCT GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTI7 GGGAGGTGTA CCAGGGAGTG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATrGTGTA AGGA'rrGAGG GACAGTTGCT T-3' (FRAG. NO:2275) (SEQ. ID NO:2448) TGATCCTATC ACAACCTGAG AGTAGTT1TTr ACTCCATTTA CAGGTGAGGT CATTGTGGTT CAAGGACGTT AAGTAACT-FC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATITTT CTCTTTTAAT CGGCTTTGAG AGGCTCAAAG GTGACCAACT CCCT-rGGGAG GGCCCCGGTT CCTCCCATCA CGGAAGCT-rC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTrA CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA GCTTCTCCTT GCCCTGGCTG GYTGTCCTTA ACCCCTGTCT CCTTCTGGAC TGACCTGAGG GGTAACAGCC TCTTTTCCAC TFC1TrTCAG CGCCGACATG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT ATCCAGCCCC CCT-rCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTrCG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG GCTCTACAGC YFGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGC1TGTG TCATCAGCTA TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG T-rcAAGGAGA ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGGC 295 AACCCAGTAG GACTATCTGG GTGCT-GCT GATAGAAGGT GGGCTGGCCA TGGTCTCCAA AAATTAACTC ACCCACCACA GATAAGGAAG GAATGTGAAT GTTAGTGCTG TTGGTGGATA GATCCAAGGA TCAGAGGGGG ACAGCCTGAG CTCCACCTCG CAGTTTGT CCT-rCCCT-rG CTCAATGTCA CCTrFGCAAGG GGCTGGGCTG GCTCAACACC CATCTTTGTC CTCAGCGTCT CTGGCCGCAG CAGACCTGAT ACTGGCTCTT TGGGGAGACG CTGTTTCCTG ATGCTGGTGA CGCGGCGTGC GCTGGGCCAA TGCTGGTGTT CCGGACCATG CCCATCCCTC ATCTGGGAAG GTCATCACCT TCTGCACGAT TCCAGACGGA GAGGAGGGCC CTrCCAGATC AGCACCTTCC ATCATCGATG TAATCACACA GATCGCCTCC TrCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT TrCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT GTTGCTT-rTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA TGTCTCCGOT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTI'CGA GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG CCCGTGTGTr CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCTTTAATCT ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTTGATAAC ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA ACGTGATCGT GGGCAAGCGC CTGCAGGTCA GAACCCATTC CAGATTCACA AACTGCAGGA

TGTGTAAGGA

CCTTGGGAAA

GGGAGCATGG

GTTCTTATTfr

AGGAGTGACT

GAACTGCCAT

ATCAGCTAGA

AACCTGGAGA

TAAGCACATA

TGTATATCAG TATTGAGCAC TGTAGGCA (FRAG. NO:2275) (SEQ. ID NO :2447) CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA

CTTCTGGACC

CGCCGACATG

CAAGTGGAGT

CCCTAGAGAA

CCTGGGGAAC

AACAACTTCG

ACAGCAGCAT

GGGCCGGATG

AGCTCACCCA

TCATCAGCTA

GCCCCTGAGT

T1'CAAGGAGA

GCTGGCTGCC

GGACGAGCGC

CCACTGGTGT

AGTT1TTTGTC CT-rCCC'FrGT GACCCTGAGG GGTAACAGCC CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT TGCTGGTGT[ CCGGACCATG AAGGAGTACA GCGATGAGGG CCCATCCCTC ATCTGGGAAG TGTIrCACCAA CATGCTCCTG

TCTTTTCCAC

TTGCCCAGAG

GGTGCTG11TC

TGCACGGTGG

TCTGGGCCAT

CATTATCTCC

CTGGTGAAAA

GGGGGTGTAC

CCACAACGTC

AATGTCGTGG

TTGAGGGACA

TGAGTGTTGA

CTGTGAGGAT

GCTGCCACAC

GAGCTTCCCT

CCACGTTTGG

ACTTTGAAGG

CCAGGATTTT

TGAGCACTTC

CCCCTGTCTC

TTTC'FrTCAG

CAAATGCCCC

GTGCTGGCCA

CAGAGATCTA

CACCATCTCC

ATGAACCTGT

CCATGTCCAT

GCTGCTCCTG

ACCGCTTGTG

GCTTCCTGCT

GATGCAGAAG

TTCATCATCT

CCAGCTGCCA

CTGCCTCAAC

GGAGTGTGCC

GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA CTI7CCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC

CGTGGAACGC

GCTGTGAATT

CTATGCACGA

A1TFrGCAGG

GCATTACTGT

GGCAGGGAGA

TCTCCAGGAG

CT~AATCTA

CCTGATAACA

GAAGAATCCA

CAGATTCACA AACTGCAGGA CTGGGCAGGG TGTGTAAGGA TTGAGGGACA GTTGCrTT~C CCTTGGGAAA TGAGTTGATG TCTCCGGTAA GAGCATGGCT GTGAGGATGG GGTGAACTCA TCTTATTTGC TGCCACACCT GAGCCAGCCT GGAGTGACTG AGCTTCCCTC CCGTGTGTTrC AACTGCCATC CAGCTTTGGT GCAATGGCTG TTCAGCTAGA ACTTTGAAGG ACAATTfCTTF ACCTGGAGAC CAGGATTTTA TGGCTCCCCT ATAAGCACAT ATTGAGCACT TGCTGTATAT AGCAGACAGT GAGCAAACGC CAGCAGGGCT AGCATGGGCC CAGGAATGCC AAGGAGACAT AACACCGGAG ACTAATrCCT GNCCTGCCCA CGCACAGCCA AGGACTCCAA AATCACAACA GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG TCCGTCCCTG CCCCAGCAAG ACAACTTAGA AGTGCACAAG TGAGTTGTTG CCCTGGGTfT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CACTGATGGA CAAGGGAGGT CTGTGCCAAA GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTI'CGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTITCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGU-CCCTC YrCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATITACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA -3' (FRAG. NO:2275) (SEQ. ID NO:2446) AAATGATAGA CCGTCAATAA T1TGTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TFUGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATJ7AC GCTTCAAACA CATGATCTCT CACCACTGTT GAAT]TCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTI7GAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC 'FrGCAAGTG TCCAAACCCT GATCCCAGCT GTGCYI7AGGG GTrCCTGCAA ACCT3TTCCA GGTGTrAATT ACCTCCCACT TCATTTCCTG TYFrACCAACT CAGCYT- G 1TTAGTGTG MrGAA'FrCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TrGGACATGC ATAGACCACA GCTTTFCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTITGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTITTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TT1GACAGCAC CTFGTAA'TG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCOCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCT1TAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC 1TrCTCCTCT AAATCAGCCC CCCATCTCTG CC17TGCAGG AGATGGAAGC CATGACACCT 296

GCCTCGCCCC

CCTCTGGAAT

CACTCTACCC

CCAACCTGAC

TCTCATCAAT

TGCTTGATTT

GTAGACTGTC

AGTCAGGGAC

CTGTGCCATC

CCAAATGTTC

TCTTrCAGGT

CCCTGGAAAG

AAAACCTCTC

AGAGGGGCTC

GAAGTGAAGG

CYITGGAAACA

TrAAGGGGAG

GCATTTGCAA

GAAGATGAGC

AGCAGGCATC

ACTGTCTTGC

AAGATGATAG

GGGTTGGACC

TCATGGGTCA

GGAAGATTCA

GTGGCAAGTT

GCAATGCAAA

TGTCCTCACC

CCAGTCTCTC

CCACTGCAGT

TGAGATATCC

AATCCACTCC

TTCACTGTAC

AGCTCCTAGC

TCAGCAGjTCT

TAACCATCTT

TCTCCCTGGA

GAGTCAAAGG

CCATCCATGT

AGTCTCCATC

CCTGACTTCC

TCCTGCACCA

CCTCACAGGC

TTAGGTCAGT

CATTGTATAC

CCATTTCTCC

TTCTTCTCTG

AGATATCAAT

GATTCCTCAG

CCAATCAAGC

ATCCCAGGTC

TGAGCAGCAG

TCATCCCTCC

GCGTTTGGGA

TTGCAGTTAT

CTAGCACCGC

GCCCTGCTGG

TI7CAGCCCAG GTTTrCTGTCT

TTCACTAGTT

CAACAGTTGA

GAATCTTGGG

ACTAGGCATG

GAAGCTAATG

CCAGGGCCTA

ACCCTGTTTA

CCCCATGTTC

TAAGTGACTG

TGTGTGGGAG

AGAATGCGTG

GTGTGGCCTC

GTTCGTGAGG

kGGGGAGGTG

AGGAACCATG

AGCAGAGGGA

TCAGG1TTTAC CCTCTAAACT GGCTAACTGG TCCTTGCTTC ATCGATATTC ACACCAAGCG GTTCTGCTCA CCCTCAGTGT TATGCTCTCA CAGGACCTTT AGCAATGTCT GGCT-fCTCCA CACGTGACAA ACGTCCAGTG TATTFTGGCAA TCCCCAGCCC ACTCACATCC CACTCTGAGT ACTCCGTGCC CACCACGGCC GGCAGACACC CTGGAGAACT GTGATGTTAA GCCCAAAGAC ATGTTCTGTG GTCTAGAGGA ATCTATCCCA GATGAACT-TG ACAGCAATGT GCCAGATTGC GAACACCCTA AAGAGAGAAT CTCAACTCTC ATGCCCCGGA AGGTGTCCAA GTCCCTGTTG AGGGAGGAGA AGGGCACA~I 1' CCTGGTTGTT ATATGTTTCT GAAGAGAGTT AAACATJ7AAA GTAAATACCC AGTGGATCAG AAATATCTCC AACACATGGC TGACAT7TGG TGGGAGATCA GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC GAAACAAGGC TGAGGGGTCC ACTCCAACCT AGATGGCCAT CTCAGCTGGG GCCACAGTGC TTTCTGATGA TCCGATGGCT TCTCAGAGCC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA ACTCTCCAAG CCAGGGGTAT GCAGGAAATG AAGGGACTAC CCAGGGGAAG TCTTACCTTrC AGAATTCAGA GCCCAGTAGA GACAGCTTAT AAGGCTAGGA AACCAGGAGC CACCAAAAGC GGTTCCCCCC ATGTGGCTGC TTGAGTATCC AGGCCAAGAA AGATGCTGCA AAGATGTTAT AGAGGATAGG GAGATCTGTT CTCCACCCTG CTGCAGGTGC ACTGGACCTA TAGTTTCCAA

CTTGGGGACA

TGCCTATGAT

TTCCGCACTC

AGGGATGGGC

TACTTTGGTC

GGT1TTCTGT

AGAGGACTCT

CTCTGTTCCA

GTAACTGGGG

TCACATGGCG

GACCTAGCCT

GAGGAAGCAG

CACCACAGGG

CCTCACTTCC

TCCTGTCCAA

GCTGTTCCCC

CAGCTCTAGA

GCTCCCTCCA

TGCCACCATT AGTAAGAAGT GAATATCAAG TAATTCGGGG TfrATACCATC ACTGTAGTTC CGCTTACTCC CTCACTCAAC AACATACCAA CAGCTTCCCC CCT[CT-fGTC CGGTCAAAAT CACCAGCCCC CTCTCCAAGT GCCACAGTTG TCAGGAGTCA AGAGCTCAGC ACAGAGCAGA TCTGGCTCCA GGATGCCAGC TGATCAGTAA TCTCTCCCGT CAGAAAGAGC CCCTJTI-7CCT TCTGGGTTGT GC'TTGGACT CCAGCCCACG TCCAGGAGAA GGCATATGAA AGCCACCACA CTTAAGACTC AGGGGCAAAG CTCTTGCTAC TTCCCACCTC AGTTCTGTGC CTCTGCTCAG GCTTCTTATC CTTCAAGACC CTGTGTCCCA CAACCCCCCT CAGGATCCAT CCCCTTGGCT TCTAGTGAGT TAGCTCATGA AGCTACAGAA ATGGGGTTGA GGAAAGGAGG CTGCAAGTTT AGATGTCTGG GGCCTJTGGTT CCAGAGGATC CACTTTCAAG GCTCACATCC UFCCAAGTAA CAGAAATCAC ACACCATCCC AUTCCTCCTT TTGAAATGAA ATCfTT]-AG AGCATACTTC TTrAGCACCCA GTGAAGACCA CATCTAGTGT CACTTTCCAG CTGCCTGGTC CACTTGTCCT GTCACCTCCA ACCCCTrACC GGGCACCCTC CACCCTCTGG TGTGTTCTTG CACTCAGGGC TTGA1TTTGTG GGTCCCCCAG GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT CGCTCAAAAA ACATTTAAAG GATAGAAGCA

CAGCTGCTCC

GACTCGTAGT

TCTCTCACCC

TT-rCAGTGTG TAGAAGCAAA CGGACTITTC CTGGGAAATC CCAGAGGTGA GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGAGATCA AGCAAM~GC CCAAGACCAC CTCTGCTGAA GGTAGAGATG AATTACAGCA TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT CACTGATAAT AAGGGTGCAA AATGTAAATT TGCACATTGT CTCTGATCCC TATGACAACC TCAGCTCTTC CTCCATGAGC ACAGCACAGG GCACTGGGAA TCTCGCATCC ACTCTTCAAC AGAGCAATAC CCTACTCCAA ACAGCTAGGA GTGGAACTCA ACAAGTCTAG AAAGGTGCCT TAAAGATGAG GTCACCAACA ACTAATG117T ATTGAGCCTA CTGAGAGGTA GTGGTTTTAA CTGACTATCA GTGGACCTTC AATGCCCAAT GAGTCCTGCC TTGAATGTTG CAACAGCCAT AGAAGGCAAC ATAGAAGCTC TGGCTGTCCA AGCCCCATGC GCCCTATGGT CTGTGAGTCT ACGGTGGTGT TGGAGTTTAC GTGCAGTGCG TGGGGCATTT CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTr CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTJTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT YITCTCTTTT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCC'rrGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTG11TGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTI'CTCC TFGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCYTCTGG ACCAGTTT GTCCTITCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACT-1TCTTr CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTrfAACGGGA CCTTrGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTrCCT CTGGGTGCTG FTCGTGCTGG CCACCCTAGA GAACATCT-IT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TOOCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTfl7CTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CITGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GYrCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTr GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTJ7CAC CAACATGCTC CTGAATGTCG TGGGC117CCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA 297 TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTOCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGACCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAAT'rrTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTAI-F TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAAC'Ff AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TfrGCCCTGGG TrTCTTTAAT CTATTCAGCT AGAACTTTGA AGGACAAThF CTTFGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGY[CGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC-3 (FRAG.NO:2275) (SEQ. D NO:2445) AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCT-rT-C AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTrGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCYI7AMfGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GOGAGGOAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTrTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTrTAATrCTA TTrCAGCTAGA ACTTTrGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTJ7CGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAcX3TTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTrCCCTT TTATGTAACA TGAAGTCGF[ GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTrT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA UTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCA1T1TGGAG AGAAGGCCAT GTC11TCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT T-rCTAATCGJG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGY-FCCTGTC AATCAATGGT 'FrATTrGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TYFCACTTGAT AAATGAATAT TTATTAGCTG GY[GGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGYIJGT CACACAGGOC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TT1AGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGOCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCYFTTC TGTAGAGCAT AATAAATGGA TGAGGT1Tr GCAAAAAAAA AAAAAAAAA-3 (FRAG. NO:2275) (SEQ. ID NO:2444) GAGCTCTrCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGAT AAAGCACAGA CACACCTTT CAGAGGGCTr GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTT[ GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTI'CC CCAGATCCAC TGGGCCCACT CTTATCTG1T CTCTTCTGAA GGAAGGGTT7 TAAGGCTTCA AAAAAAAATG TrTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTI'CTGCC ACTGTCGCCC TrGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTFA CACC'rrCCGC GTAAACGCCC ACTGTTFACA TCCAAAACTC AGACACAAAA TAACCACCTC 298 AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TTCCCAGGCC ACTITGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TrCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTTr CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTGA GCTGGAGc3CG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCUTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGT[GGGAAA AGTJ7CCCTTC CTJ7CCGGAGG GAGG-3' (FRAG.NO:2275) (SEQ. ID NO:2443) GCCCTFFCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTfG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTCCCTG TGGTCGTGGG GAGTT -3' (FRAG. NO:2275) (SEQ. ID NO:2442) AAATGATAGA CCGTCAATAA TTrGTTAAAT GC1T[TTAAA ATGAATGC'Fr TAAGCCGGGT GCAGTGCCTC

ACATCTGTAA

GGCCAACATG

TGATCCCAGC

AAGATTACGC

AAAAAATTAC

TCTCAGAGAG

TGTGCGTGCT

ACC'TTCCA

1TTTGAATTCC

AAACCCAGGT

ACACACACAC

ATAGACCACA

GGAATGGAAA

TGCGCCTTGT

GAAACFTGAA

GGGGCACAGA

CTGGAAATAC

GTGCTCCAGT

CCCCACCTGC

ACACATGACC

GCCTCGCCCC

CCTCTGGAAT

CACTCTACCC

CCAACCTGAC

TCTCATCAAT

TGCTTGAT'F7

GTAGACTGTC

AGTCAGGGAC

CTGTGCCATC

CCAAATGTTC

TCTT7CAGGT TCCCAGCACT TTGGAGCCGA GCGGGTGGAT GCAAAACCTC ACTCTCTACC AAAAATACAA TACTCAGGAG GCTGAGACAG GAGAATCGCT CATTGTACTC CAGCCTGGGT GACAGAGAGA TGTGTGAGGT CAGGAGTTCG AGACCAACCT AAATTAGCCA GGCATGGTGG CAGGCACCTG TGAACCCGGG AGGCAAGGTT GCAGTGAGCC GACTCCGTCT CAAAAAAAAA AAAAAAAAAA

GCTTCAAACA

GAAAGCTCCT

CGTTGCATCC

GGTGTTAATT

CTGAACTGAC

GCCGGGTGTT

ACCCACATAC

GCTTTCCACA

CATGATCTCT

AGGTCTTCCT

1TrGCAAGTG

ACCTCCCACT

CGTITGTCTGA

GCAGAGTGGC

CCACACATGC

CCCTTCCTAG

CACCACTG'Ff

TTCCCTCTGC

TCCAAACCCT

TCATTTCCTG

GAATTTTCTT

AAACTCCCTG

GATCCCAGCT

T17ACCAACT

TCTATGAGCC

CC'FfGAAGGT

GTGCTITAGGG

CAGC'TITrG

TAGGGGAGCT

ATCCGTGGCT

ACTCACACAC

TGGAGAGAGT

CAGGAGGGCC

TCAGAAGGAC

GTTCCTGCAA

TTTTAGTGTG

GGGCTTCTGG

ACATITCATGC

TTGGACATGC

GTGAAGTCCT

TCTCCACCTC CCAACTGAAT TGAAAGCTGG GATGTGGCAG ACACACACAC ACACACCCGC ACAGGGGTCA CTTGGTATCC GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTJTGGG AAAAAAGGCC CTTTCAACTA

GGAGGCCCTG

TCAGATGTGT

CCAGACCCCT

CTGGAATTCT

TTTCTCCTCT

TGTCCTCACC

CCAGTCTCTC

CCACTGCAGT

TGAGATATCC

AATCCACTCC

TFTCACTGTAC

AGCTCCTAGC

TCAGCAGTCT

TAACCATCTT

TCTCCCTGGA

GAGTCAAAGG

GGCTGAGAAC TTGACAGCAC C'YfGTAATTG CTGTCTCCCT TATTAGGTTC AAAGTCCCTC CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAAAGAACC TCCCCTTTAA CAG'FrCCAGC

AAATCAGCCC

CCATCCATGT

AGTCTCCATC

CCTGACTTCC

TCCTGCACCA

CCTCACAGGC

TTAGGTCAGT

CATTGTATAC

CCATTrCTCC CCCATCTCTG CC1TIGCAGG

CCAATCAAGC

ATCCCAGGTC

TGAGCAGCAG

TCATCCCTCC

GCGTTTGGGA

TTGCAGTTAT

CTAGCACCGC

GCCCTGCTGG

ACTAGGCATG

GAAGCTAATG

CCAGGGCCTA

ACCCTGTTTA

CCCCATGTTC

TAAGTGACTG

TGTGTGGGAG

AGAATGCGTG

GTGTGGCCTC

GTTCGTGAGG

AGGGGAGGTG

AGGAACCATG

AGCAGAGGGA

GTAAGCCAAG CCCGAAGGGA AAGACCCTGT CTCCATCACA CCAGCCCTAT GGGGTCGCAT CT17AACAGT TCCAGTCTAA AGATGGAAGC CATGACACCT TCAGGTTrAC CCTCTAAACT GGCTAACTGG TCCTTGCTTC ATCGATATTC ACACCAAGCG GTTCTGCTCA CCCTCAGTGT TATGCTCTCA CAGGACCTTr AGCAATGTCT GGCTTCTCCA CACGTGACAA ACGTCCAGTG TATTTGGCAA TCCCCAGCCC ACTCACATCC CACTCTGAGT ACTCCGTGCC CACCACGGCC GGCAGACACC CTGGAGAACT GTGATGTTAA GCCCAAAGAC ATGTTCTGTG GTCTAGAGGA TTCTTCTCTG TTCAGCCCAG AGATATCAAT GT'rrCTGTCT GATTCCTCAG TTCACTAGTT ATGCCCCGGA CAACAGTTGA GTCCCTGTTG GAATCTTrGGG CCCTGGAAAG CTCAACTCTC AAAACCTCTC AGGTGTCCAA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTF ATATGTTTCT ATCTATCCCA GATGAAC117G GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACA'FFTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT ITFAAGGGGAG GGGGAGGAGG GCATTGCAA GAAACAAGGC GAAGATGAGC AGATGGCCAT AGCAGGCATC TTTCTGATGA ACTGTCUTGC TGAGAAA'rrr AAGATGATAG ACTCTCCAAG GGGTTGGACC AAGGGACTAC TCATGGGTCA AGAATTCAGA GGAAGAYI7CA AAGGCTAGGA GTGGCAAGTr GGTTCCCCCC GCAATGCAAA AGGCCAAGAA TGCCACCATT AGTAAGAAGT GAATATCAAG TAATTCGGGG TTATACCATC ACTGTAGTrC CGCTTACTCC CTCACTCAAC ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTr C117GGGGACA TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAG3-TTCCAA TJTCCGCACTC TCCGATGOCT TCTCAGAGCC AGGOATGGGC CAGGATCCAT CCCCTFFGGCT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA CCAGGGGTAT GCAGGAAATG GGTTTCTGT AGCTACAGAA ATGGGGTTGA CCAGGGGAAG TCUTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTr GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACITUTCAAG ATGTGGCTGC TrGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTr TTGAAATGAA GGCATATGAA AGCCACCACA CACCACAGGG ATCTTTrAG AGCATACTTC CTUAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CTCTITGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG 299 AACATACCAA CAGCU-CCCC CCTTCTTGTC CGGTCAAAAT CACCAGCCCC CTCTCCAAGT GCCACAGTTG TCAGGAGTCA AGAGCTCAGC ACAGAGGAGA TCTGGCTCCA GGATGCCAGC TGATCAGTAA TCTCTCCCGT CAGAAAGAGC CCCTI=CCT TCTGGGTTGT GCFJTTGGACT AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC GCTTCTTATC CTTCAAGACC CAGGICTAGA GTCACCTCCA CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG

CACTTGTCCT

ACCCC11TACC

CACCCTCTGG

CACTCAGGGC

CGCTCAAAAA ACATTTAAAG CAGCTGCTCC TAGAAGCAAA GACTCGTAGT TCAGCTCTTC TCTCTCACCC ACAGCACAGG GATAGAAGCA TTGAMTGTG GGTCCCCCAG CGGACUTTTC CTGGGAAATC CCAGAGGTGA

TTTCAGTGTG

GAAAAAAGAA

AGAGAGATCA

CTCTGCTGAA

TGCCTAAGAA

CACTGATAAT

TGCACATITGT

ATGCAAAGCG ATTCAGGATG AGCAATTTGC CCAAGACCAC GGTAGAGATG AATTACAGCA TGAAAGAGGA GCCAGTGGGT AAGGGTGCAA AATGTAAATT CTCTGATCCC TATGACAACC

TCTCGCATCC

AGAGCAATAC

ACAGCTAGGA

ACAAGTCTAG

TAAAGATGAG

ACTAATGTYI7

CTGAGAGGTA

CTCCATGAGC

GCACTGGGAA

ACTCTTCAAC

CCTACTCCAA

GTGGAACTCA

AAAGGTGCCT

GTCACCAACA

ATTGAGCCTA

GTGGTTTTAA

CTGACTATCA

AATGCCCAAT

TTGAATGTTG

AGAAGGCAAC

TGGCTGTCCA

GCCCTATGGT

ACGGTGGTGT

GTGCAGTGCG

CTGCCATGTT

GTGGACCTTC

GAGTCCTGCC

CAACAGCCAT

ATAGAAGCTC

AGCCCCATGC

CTGTGAGTCT

TGGAGTTTAC

TGGGGCATTT

ACAGGTGAGG

TCATTGTGGT TCAAGGACGT TAAGTAACTr CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTrTCTCTTTT AATAAATTAA CTCACCCACC ACACGGCTUT GAGAGGCTCA AAGTTGACCA ACTCCCTFGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTI'GGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATOCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TrGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTT-rTT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACT1TCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTrAACGGGA CCTFTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTr GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CT-FTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GYI7CCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCY-r GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTrCAC CAACATGCTC CTGAATGTCG TGGGCTTFCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTfrCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGiC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTrCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TF7CAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGAITGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAA1TTrTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCC'IT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TITGCCCTGGG TTTCTTTAAT CTATITCAGCT AGAACTrTGA AGGACAATTT CrrGCATrIAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTFCC AGCTCACCAA TACTAFJTGCA CACCACCTGT CCTGCCTC (FRAQ. NO: 9 (SEQ. ID NO 2441) AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTrGGGAAA TGAGTrGATG TCTCCGGTAA AACACCGGAG ACTAAYJTCCT GCCCTGCCCA ATITTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATrTACTGT TCTTATrGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC AACTGCCATC CAGCTTTGGT TJTCAGCTAGA ACTTTGAAGG ACCTGGAGAC CAGGATTTTA TAAGCACATA 'F7GAGCACTT AGCCATCTCC ATCTTGAAGG TGTTCGACGA GACGGTCGAG GCTCAACCAA TAACTATTGC CCGTGTGTrC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTr CTITAATCTA ACAATYI7CTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTrCCA ACAACCACCT GTCCCTGCCT CAGTTCCCTl TTATGTAACA TGAAGTCGTT GTGAGGGT-rA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA 300 TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTI'GGAG AGAAGGCCAT GTCTTCAAAG TCTGATrTGT GATGAGGCAG AGGAAGATAT 17CTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGUTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GUTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTrA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTrACC CCCAACCCAC TCTTTTTrCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT GCAAAAAAAA AAAAAAAAA (FRAQ. NO: _9 (SEQ. ID NO 2431) 5'-GGTGBCBT-fGBGCBTGTCGGCGC-3' (FRAG. NO:2276) (SEQ. ID NO:2289) 5'-GGTCCCGTTBBGBGTGGGCCC-3' (FRAG. NO:2277) (SEQ. ID NO:2290) (FRAG. NO:2278) (SEQ. ID NO:2291) 5'-GGGTGGCCAGCACGAACAGCACCCAGAGGAAGGGGGGC-3' (FRAG. NO:2279) (SEQ. ID NO:2292) -3 (FRAG. No:228O) (SEQ. ID NO:2293) 5'-GGAGATAATGGCA~fCACCACGCGGC -3 (FRAG. NO:2281) (SEQ. ID NO:2294) (FRAG. NO:2282) (SEQ. ID NO :2295) 5'-GGGTfTCTGACCTGCAGCCCCC-3' (FRAG. NO:2283) (SEQ. ID NO:2296) (FRAG. NO:2284) (SEQ. ID NO: 2297) 5'-CAGTCACTCCTCTCCCTGCCCCC-3' (FRAG. NO:2285) (SEQ. ID NO:2298) 5'-CTTGCTGGGGCAGGGACGG-3' (FRAG. NO:2286) (SEQ. ID NO:2299) 5'-GGTGBCBTTGBGCBTGTCGGCGC-3' (FRAG. NO:2287) (SEQ. ID NO:2300) 5'-GGTCCCGTTBBGBGTGGGCCC-3' (FRAG. 110:2288) (SEQ. ID 110:2301) 5'-GCCAGCCCAGCCACTCCACTTGGGGGC-3' (FRAG. 110:2289) (SEQ. ID 110:2302) 3' (FRAG. NO :2290) (SEQ. ID NO :2303) 5'-GGCCCAGAAGGGCAGCCCGCAGGCCAGGATCAGGTCTGCTGCGGCC- 3' (FRAG .NO: 2291) (SEQ. ID NO:2304) 5'-GGAGATAATGGCATTCACCACGCGGC-3' (FRAG. NO:2292) (SEQ. ID NO:2305) 5'-GGCCCAGCGCACGCCGCGCATCCGGCCC-3' (FRAG. NO: 2293) (SEQ. ID NO:23O6) 5'-GGGTTCTGACCTGCAGCCCCC-3' (FRAG. 110:2294) (SEQ. ID 110:2307) 5'-GTCTCCTTGGCATTCCTGGGCCC-3' (FRAG. 110:2295) (SEQ. ID NO:2308) 4 5 5'-CAGTCACTCCTCTCCCTGCCCCC-3- (FRAG. 110:2296) (SEQ. ID 110:2309) 5'-CTTGCTGGGGCAGGGACGG-3' (FRAG. NO:2297) (SEQ. ID 110:2310) 5'-CCGTGTTGTCBGTGGTGCTG-3' (FRAG. 110:2298) (SEQ. ID NO:2311) 5'-CCCGTTTGBGGTBTGGC-3' (FRAG. 110:2299) (SEQ. ID K10:2312) 5'-GCTCCBCCBBTTCCCTTTTCTCC-3' (FRAG. NO:2300) (SEQ. ID 110:2313) 5'-TTGTTTTCCGTTTCTCTTG-3' (FRAG. NO:2301) (SEQ. ID 110:2314) 5'-CCGTCTGTGGTT-3' (FRAG. 110:2302) (SEQ. ID K10:2315) D32 Adrener~ic Receptor Kinase Nucleic Acids and Antisense Olieonucleotide Fra2ments GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACC'TrF GAGAAGATCT TrTCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC CTGGAGGAGG CCAGGCCCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGCTCGCA TCCC'ITCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC 'rrCCAGCCAT ACATCGAAGA GA~i-rGTCAA AACCTCCGAG GGGACGTGTrF CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGGTTTTGC CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC ATCATTGGGC GCGGGGGCTr TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA 301.

TGAAGCAGGG GGAGACCCTG GCCCTGAACG AGCGCATCAT GGTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC TGCATGTCAT ACGCGTTGCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC T"TCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCT-F CGTGGTCTAC CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGGCCTGG CCTGTGACTTF CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCTCTr CAAGTTGCTG CGGGGGCACA GCCCCTfCCG GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC TCCTTrCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTr TTTCCGCTCC CTGJGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG GAGGTGAACG CGGCCGACGC CTTCGACATT OGCTCCTTCG ATOAGGAGGA CACAAAAGGA ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG CGGTGGCAGC AGGAGGTGGC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG TGGCAGCGGC GGTACTTCTA CCTG'TCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AGTTCATTTT GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG ACGCCTACCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GGTGGAGCTG AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCAGGAAGCT ACCTGGAGGA GGTGAGTCTT AAGGGCTTCC AGGCCCAGGA AACAGCAGAG TCCAGGTGCA GAGGATGGTA GCGAAACAAA CAGATTAAGG AGT-rTGTTCA CCTAATCTGC CTCTCCTCTC AGTAGCCCCA GAAGGCCTGG GATCTAGA'IT TGGGAAAAGC ATCCCTGGTC AGAAGTAGAC AGATTCACGG AGATTCTCAG AAGGGGAGAG AATGAAGGAG CAGUTGGGGT TGACTCACCA CCCACTGAGA GGAGAACCTC TGATCCAAGA TGGTAGCCTA GAGGTGCACA GCCCACAGCA TGGTAATGAG ATTTGAGCTT AGCAAAGAGA GGCTCTAGAG AGGGGCATGT CTCTGGGTGG CTCTCAGCAG GGTGGGTTTC GGAGAGTTTT TACCGTAACT ACATGTGGAA AGCGGATGAG TAGGAGTTGT CCACGGAGGA GCACAGAAGT GAGAATGGGT GGGTGAGTTG CTGGAGCATr AAGGTCCAAG TCCTCCAAGA TTTGGGCAGA GTGTGGTGAG AGAGCTGCTT CTGGGTGCCA AGGGCCTGCA TCAGGGCAGT GAGGCCAGAC AGGAGACTAT AAAAGAAAAC TGAGGCTGAC ACAAGCTCTG ACATGCTCTG GAGATGGGGG CC1TGCTTTG TATGTGCCCA GGGCTGGGAG TGAGATAGGA ATGCTGCCTT CCCTGCCAGG CAGCACTGAA

TCCTAGAGAC

AGCAGGCAGT

GGCTGGCCAT

GGTGACAAAT

ATGGGTATAT

GTTCCAGGTT

CAAAAGGATG

GAGGGTCCTG

GAGACACCTG

CCTCTGTGCG

GAGCTGCGCG

GCTCGCCCGT

CCACCCGCCT

AGGTACACAG

GTGGGGAAAC

TCTTGACTTG

CCCTCTAGGT

GACTCCATCA

GAGGACCCTG

TAGATTAGAG

GGGTGGCGAG

CTGTTGGGGC

CTGGCTGCTG

TCACT[TGAA

GCTTTCCCCA

CTTCCGGCTG

CCATCCTGAA GGAACATCTG GATGGGATGG GGTACAGGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT GAGCTGGTTG GGGGGTGGGG TTGGGTGCAG GGTACTTGAT CCTGAGTGGG CCTTCTGCGG GGGGGAAGCC TGTAACTGCG CTGCAGTTGT

CCAGGATTGG

CAGGTCCCAG

TTCTAGAGTA GGAGGGGTGG GATCGGGGAT GTTCTGGGTG ACCTACTAAG GATTCTGGGT CCAGTGTGGG TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTCCACAG TTCTGGGTGT TGAGTCTAGG ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAGTC CTGACCCCAA GTCTAGAGTT CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGTCAGTAAC CAGGATGGGA TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG GTGAGTGTCG CAGTCTGGGT ATGGCGTTGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTCTCA GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTGTYFGGAG TCTGGTGTCA GGTCGTGGAC TGCGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG GTGTTCAGAG GTCTGAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTTG GTGTCAGGGC TGCGGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG GTCAGAGAAT GGGTCTCGGG TCGTCTTCGT GCCGGGTCCC TGTCGTGTTFC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG CCGAGGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC TGGTTCGGGG TCAGATTCCG CGCGGCCTCC AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGGGGCCG GAGGCGGCGG CGGCTCCGGG GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCGGCG GGAGCGGAGC GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GTGAGCGGCG GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC CGAGGCCGAG CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG TGAGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA AGATACTOCT GCCCGAGCCC AGGTGAGGAG AAGCT-3' (WAG.

(SEQ. ID NO:2430) ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTTGT CCACGGAGGA AGOTACACAG AAGGGCTITCC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT GGGTGAGTTG GTGOGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATT AAGGTCCAAG TCCTCCAAGA TCTI7GACTrG CAGATTAAGG AGTTTGTTCA CCTAATCTGC CTCTCCTCTC AGTAGCCCCA GAAGGCCTGG GATCTAGATr TGGGAAAAGC ATCCCTGGTC AGAAGTAGAC AGATTCACGG AGATTCTCAG AAGGGGAGAG AATGAAGGAG CAGU-GGGGT TGACTCACCA CCCACTGAGA GGAGAACCTC TGATCCAAGA TGGTAGCCTA GAGGTGCACA TTTGGGCAGA GTGTGGTGAG TCCTAGAGAC CCCTCTAGGT AGAGCTGCTT CTGGGTGCCA AGCAGGCAGT GACTCCATCA AGGGCCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG GAGGCCAGAC AGGAGACTAT GGTGACAAAT TAGATTAGAG AAAAGAAAAC TGAGGCTGAC ATGGGTATAT GGGTGGCGAG ACAAGCTCTG ACATGCTCTG GUTCCAGGTT CTGTTGGGGC GAGATGGGGG CCrrGCMTG CAAAAGGATG CTGGCTGCTG 302 GCCCACAGCA TGGTAATGAG ATTTGAGCTT TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACT-fTGAA AGCAAAGAGA GGCTCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGCCTT GAGACACCTG GCT'rrCCCCA CTCTGGGTGG CTCTCAGCAG GGTGGGTTTC CCCTGCCAGG CAGCACTGAA CCTCTGTGCG CTTCCGGCTG GGAGAGTTTT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG GATGGGATGG GGTACAdGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT GAGCTGGTTG GGGGGTGGGG TTGGGTGCAG GGTACTTGAT CCTGAGTGGG CCT-rCTGCGG CCAGGATTGG TI'CTAGAGTA GGAGGGGTGG GATCGGGGAT GGGGGAAGCC TGTAACTGCG CTGCAGTTGT CAGGTCCCAG GTTCTGGGTG ACCTACTAAG GATTCTGGGT CCAGTGTGGG TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTCCACAG TrCTGGGTGT TGAGTCTAGG ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAGTC CTGACCCCAA GTCTAGAGTT CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGTCAGTAAC CAGGATGGGA TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG GTGAGTGTCG CAGTCTGGGT ATGGCGT-rGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTCTCA GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTGTTTGGAG TCTGGTGTCA GGTCGTGGAC TGCGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG GTGTTCAGAG GTCTGAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTrTG GTGTCAGGGC TGCGGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG GTCAGAGAAT GGGTCTCGGG TCGTCTTCGT GCCGGGTCCC TGTCGTGTTC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG CCGAGGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC TGGTTCGGGG TCAGATrCCG CGCGGCCTCC AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGGGGCCG GAGGCGGCGG CGGCTCCGGG GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCGGCG GGAGCGGAGC GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GTGAGCGGCG GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC COAGOCCOAG CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG TGAGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA AGATACTGCT GCCCGAGCCC AGGTGAGGAG AAGCT-3' (FRAG.

NO:) (SEQ. ID NO:2429) CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTTT GAGAAGATCT TFCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACUTCTG CCTGAACCAC CTGGAGGAGG CCAGGCCCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TrCCAGCCAT ACATCGAAGA GATTTGTCAA AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGGTTTTGC CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC ATCATrGGGC GCGGGGGCTU TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC TGCATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC TTCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGC'rF CGTGGTCTAC CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGGCCTGG CCTGTGACTT CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CGGGGGCACA GCCCCTTCCG GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCT[ TTTCCGCTCC CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG GAGGTGAACG CGGCCGACGC CUTCGACATT GGCTCCT-rCG ATGAGGAGGA CACAAAAGGA ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG CGGTGGCAGC AGGAGGTGGC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG TGGCAGCGGC GGTACTTCTA CCTGTTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AGTTCATTTU GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG ACGCCTACCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT GGTGGAGCTG AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT-3' (FRAG. (SEQ. ID NO:2428) CCR-2 CC Chemokine Receptor Nucleic Acids and Antisense Oligonucleotide Framents 5'-C1GTGAAG AAGGAATTGG CAACACTGAA ACCTCCAGAA CAAAGGCTGT CACTAAGGTC CCGCTGCCTT~ GATGGATTAT ACACTTGACC TCAGTGTGAC AACAGTGACC GACTACTACT ACCCTGATAT CTITCTCAAGC CCCTGTGATG CGGAACTTAT TCAGACAAAT GGCAAGTTGC TCCTTGCTGT CTTTTATTGC CTCCTGTTTG TATTCAGTCT TCTGGGAAAC AGCCTGGTCA TCCTGGTCCT TGTGGTCTGC AAGAAGCTGA GGAGCATCAC AGATGTATAC CTC17GAACC TGOCCCTGTC TGACCTGCTT TFMGTCT7CT CCTrCCCCIT TCAGACCTAC TATCTGCTGG ACCAGTGGGT GTTTGGGACT GTAATGTGCA AAGTGGTGTC TGGCTTTTAT TACATTGGCT TCTACAGCAG CATGTTC ATCACCCTCA TGAGTGTGGA CAGGTACCTG GCTGTTGTCC ATGCCGTGTA TGCCCTAAAG GTGAGGACGA TCAGGATGGG CACAACGCTG TGCCTGGCAG TATGOCTAAC CGCCATTATG 303 GCTACCATCC CATTGCTAGT GTfTTACCAA GTGGCCTCTG AAGATGGTGT TCTACAGTGT TATrCATTTT ACAATCAACA GACTTTGAAG TGGAAGATCT TCACCAACTr CAAAATGAAC ATTTTAGGCT TGTfGATCCC ATTCACCATC TTTATGTTCT GCTACATTAA AATCCTGCAC CAGCTGAAGA GGTGTCAAAA CCACAACAAG ACCAAGGCCA TCAGGTTGGT GCTCATTGTG GTCATTGCAT CT-rTACTT'Fr CTGGGTCCCA TTrCAACGTGG TTCTFCCT CACTTCCTTG CACAGTATGC ACATCTTGGA TGGATGTAGC ATAAGCCAAC AGCTGACTTA TGCCACCCAT GTCACAGAAA TCATTTCCTT TACTCACTGC TGTGTGAACC CTGTfATCTA TGCTT17GTT GGGGAGAAGT TCAAGAAACA CCTCTCAGAA ATATTTWAGA AAAGTTGCAG CCAAATCTTC AACTACCTAG GAAGACAAAT GCCTAGGGAG AGCTGTGAAA AGTCATCATC CTGCCAGCAG CACTCCTCCC GTTCCTCCAG CGTAGACTAC ATTYJTGTGAG GATCAATGAA GACTAAATAT AAAAAACATT TTCTTGAATG GCATGCTAGT AGCAGTGAGC AAAGGTGTGG GTGTGAAAGG TTTCCAAAAA AAGTTCAGCA TGAAGGATGC CGTGTGTGTT GTTGCCAACA CTTGGAACAC AATGACTGGA GACATAGTTrG TGCATGCCTG GCACAACATC AAGCCTGTGA TTGTGTTTAT TGATGATGTT GAACAAGTGG TGGCTTTGAG GGATTCTGTA TGCCAAGTGG AAAAAAAAGA TGTCTCCGGA AU7CGACAGG TfATCA-3' (FRAG. (SEQ. ID NO:2462) CCR-4 CC Chemokine Receptor Nucleic Acids and Antisense Olijonucleotide Fragments CCGGGCTTAT TTGCTGGTIT CTCCGAATGC GGGCCTTGTC

ACGCCTAGAA

GTAATACCCA

AGTACTGGTC

GTTACCGCTA

CCTACC'FrCT

TAGCTACATC

CGGGGGAATG

AAGTCACTCC

TAGCAAGGAT

CAGTGCGTGG CACGCAGTTC CACGGTGTTG TGAGAATGAA GCTAAATTAC TCTTATAATA TTATGAAATT ACTGAGCAAT TCTGAAAGTA TCTCCTAATT CTCCGAAGGA AGGATCTTrA GTCCT-fCTAT

TGAGTGATTC

AAGCATACTT

ACATATCTAC

ATCTGCACCT

CTCCT1TAC

AAATATCGGA

TGTGCAAGTT

TTAGGATAAT

ATCTGATCAG

GACCCTAGTG

CTCCTGAATG

TGGTTCACGC

CTAAATGCAT

CCTAGTGATC

AAAGCACTAT

TCTCCAGAAT

ATGCTGTGAA

GGCTGCGTCT

ACTGGTTGGG

GTCTGGAATT

CACCTGTCTT

TGGATCCCCA

CTCTGTGATG

TGTTACAAAA

TCGCGAATTG

TATGCCAAAT

TGTGCAAGTA

GCTGAAAGCG

TTACTCCAGC

CCATCCACTT

CAGGCGCATC

GGCGGT[GGA AGCTTGGCCC TACTTCCAGC ATTGCCGCCT CCTf7CCCTGG GCCTCAGTGT CTCTACTGTA GCAT-fCCCAG GGACGCGCCA CAGAGAGACO CGTTCCTAGC CCGCGCTTCC CCGCTrCCCT CAAACTTAGG AAATGCCTCT GGGAGGTCCT GTCCGGCTCC GGACTCACTA CCGACCACCC GCAAACAGCA GGGTCCCCTG GGCTTCCCAA GCCGCGCACC TCTCCGCCCC GCCCCTGCGC CCTCCT[CCT CGCGTCTGCC CCTCTCCCCC ACCCCGCCTT CTCCCTCCCC GCCCCAGCGG CGCATGCGCC GCGCTCGGAG CGTGTTTTTA TAAAAGTCCG GCCGCGGCCA GAAACTTCAG TTTGTTGGCT GCGGCAGCAG GTAGCAAAGT GACGCCGAGG GCCTGAGTGC TCCAGTAGCC ACCGCATCTG GAGAACCAGC GGTITACCATG GAGGGGATCA GTGTAAGTCC AGTI1CAACC TGCTTTGTCA TAAATGTACA AACGTTTGAA CTTAGAGCGC AGCCCCTCTC CGAGCGGGCA GAAGCGGCCA GGACATTGGA GGTACCCGTA CTCCAAAAAA GGGTCACCGA AAGGAGTTTT CT[FGACCATG CCTATATAGT GCGGGTGGGT GGGGGGGGAG CAGGATTGGA ATCTT'I17TCT CTGTGAGTCG AGGAGAAACG ACTGGAAAGA GCGTTCCAGT GGCTGCATGT GTCTCCCCCT TGAGTCCCGC CGCGCGCGGC

GGCTTGCACG

GGGACTCAGA

TAGAGGCGGA

AAGCGCCTGG

CAGTCTCCCA

TCGAGTGGTG

GTCCGAAGCG

GTCAGCGGAG

TAGGAGCGGG

AGACTGGCAG

GGTTTCCAGA

AGACGCTCGC

CTGTTTGCAA ACGTAAGAAC CCACCGGTCT CYrCCTTGGG GGGCGGCGTG CCTGGGCTGA TGACTGTFICT TGACACTOG GCACAGTAGG CAGAGGGCGG GCAGCAGCTA GGAGTTGATC CGCCTCTTCC CCACGGCCGC TGGTTTGACC TCCCC1TTGA TACGGGGTGA GGGGCGGGGG GTGCAAGTGG GGAAACCGTT AACCT[FTTGA AACCCTCTTG GGCGGAGCCG CCCAGTCGCT ATTCTGTGCA CAAGTGCAGA GAAGGCGTGC GAAGCGGGGA TGTCTTGGAG CGAGTTACAT CTTCCCAGGA GGAGATTGCG CCCGCTITTAA TGCGTGTTTG TTAAACTCTG TGCGGCCGAC GAGAGGCGGG TGGACCCACC GCGCCGATCC CGCCCGCGCG CTTTOGGGTTT GAGGGGGAAA GAGTGGGTCC TGCAGTTCGA GAGTTTGGGG CACCGCGCAG CTGCCAGCCC TGAGATTTGC CGGTTAAGAC CGCACCTGGG CTGCCAGGTC TGGCTCTCTC CGAGTCCAGT TGTGATGTTT CTAGGGAGTT TTrTGGTITCC TGCAGCGGCG CCCCAGCACC CTGTGGGACA GAGCCTGGCG

GCGCTGCCTC

TGTCTGAATT

CTTCGGGGTr

GGAGCTGTGC

TCTGAGGGGA

CCTTCCCGCC

TCGTGCAGAG

GCTCCGGGGA

GCCGCCGCGA

AACCGTCGGT

CGCAAYI7CAA

TGTCGCCCAG

CGGAGCCCCT GCAGCGCTGC TTGCGGGCGG TTGGCGTGGG TGTAGTGGGC AGCCGCGGCG GCCCGGGGCT GGACGACCCG GCCCCCCGCG TGCCCACCGC CTGGAGGCTT CCAGCTGCCC ACCTCCGGCC GGGTTAACTG GATCAGTGGC GGGGTAATGG GAAGCCACCC GGGAGAGTGA GGAAATGAAA CTTGGGGCGA GGACCACGGG TGCAGACCCC GTTAccTTCT CCACCCAGGA AAATGjCCCCG CTCCCTAACG TCCCAAACGC GCCAAGTGAT AAACACGAGG ATGGCAAGAG ACCCACACAC CGGAGGAGCG CCCGCTrGGG GGAGGAGGTG CCGTTrGrrC ATTrTCTGAC ACTCCCGCCC AATATACCCC AAGCACCGAA GGGCCT7CGT TT[AAGACCG CATTCTCTTr ACCCACTACA AGTTGCTTGA AGCCCAGAAT GGYITGTATT TAGGCAGGCG TGGGAAAATT AAGTTrrGC GCTAGGAG AATGAGTCTI7 TGCAACGCCC CCGCCCTCCC CCCGTGATCC TCCCTI7CTCC CCTCYrCCCT CCCTGGGCGA AAAAc~T-rT ACAAAAAGTT AATCACTGCC CCTCCTAGCA GCACCCACCC CACCCCCCAC GCCGCCTGGG AGTGGCCTCT T-rGTGTGTAT TrTTITFrC CTCCTAAGGA AGGTTTTT-rT TCTTCCCTCT AGTGGGCGGG GCAGAGGAGT TAGCCAAGAT GTGACTTTGA AACCCTCAGC GTCTCAGTGC CC1TTTTGTTC TAAACAAAGA ATTGTAAT TGGT-rCTACC AAAGAAGGAT ATAATGAAGT CACTATGGGA AAAGATGGGG AGGAGAGTTG TAGGATTCTA CATTAATTCT CTTGTGCCCT TAGCCCACTA CTTCAGAATf TCCTGAAGAA AGCAAGCCTG AATI7GGTT TTAAATTGCT TTAAAAA'ITT TT1TT7AACTG GGT-rAATGCT TGCTGAATTG GAAGTGAATG TCCATTCCTT TGCCTCTTTT OCAGATATAC ACTTCAGATA ACTACACCGA GGAAATGGGC TCAGGGGACT ATGACTCCAT GAAGGAACCC TG1TCCGTG AAGAAAATGC TAATrTCAAT AAAATCTTCC TGCCCACCAT CTACTCCATC ATCTTCTTAA CTGGCATTGT GGGCAATGGA TTGGTCATCC TGGTCATGGG TTACCAGAAG AAACTGAGAA GCATGACGGA CAAGTACAGG CTGCACCTGT CAGTGGCCGA CCTCCTCTTT GTCATCACGC 'rrCCCTTCTG GGCAGTTGAT GCCGTGGCAA ACTGGTACTT TGGGAACTTC CTATGCAAGG CAGTCCATGT CATCTACACA GTCAACCTCT ACAGCAGTGT CCTCATCCTG GCCrCATCA GTCTGGACCG 304

CTACCTGGCC

GTTGGCGTCT

ATGACAGATA

CATGGTfGGC

CACTCCAAGG

GTTGGCTGCC

TGAGTITGAG

AACCCCATCC

GCAGAGGGTC

TGAGTCTTCA

TMAAGTTA

'TTTGTCTTGT

TYfGATGTGTG

AAAGGGAACT

CATAGATAAT

GCACTTATAA

AGCACCTACA

TrCTGATrTC

TATCCTAGGT

CTAAUTACAT

AAGTATCAAA

TCAAATGGAA

ATCGTCCACG CCACCAACAG TCAGAGGCCA AGGAAGCTGT TGGCTGAAAA GGTGGTCTAT GGATCCCTGC CCTCCTGCTG ACTAUTCCCG ACTTCATCTT TGCCAACGTC AGTGAGGCAG TATCTGTGAC CGCTTCTACC CCAATGACT-r GTGGGTGGTT GTGTTCCAGT TTCAGCACAT CTTATCCTGC CTGGTATTGT CATCCTGTCC TGCTATTGCA Y[ATCATCTC CAAGCTGTCA GCCACCAGAA GCGCAAGGCC CTCAAGACCA CAGTCATCCT CATCCTGGCT TfCT-CGCCT TTACTACATT GGGATCAGCA AACACTGTGC ACAAGTGGAT TCTATGCTTT CC17GGAGCC CAGCCTCAAG ATCCTCTCCA TCGACTCCTT CATCCTCCTG GAAATCATCA TTCCATCACC GAGGCCCTAG CHrTCTTCCA AAA3TTAAAA CCTCTGCCCA GCACGCACTC

AGCAAGGGTG

CTGTTGTCTG

ACCTCTGTGA

AGTTTTCACT

CACATTI1TC

GTTTCTTTAG

TCTAGGCAGG

GAACAT[CCA

CTCTCCATTC

CCAAAGCCCA

GTGTACAGTC

TGTTGACATT

ATTI7CATTGT TTrATAGAAG TCCTGTATrT

GTTTAGAAAT

CCAGCTAACA

AGATATAAAA

TTTTTGTGAA

ACCTGTGGCC

GAGCGTGTAG

CCGTGGAACG

AAGTGGTATA

TTGTATTAAG

AAGGAAAGCG

CAGATGTAAA

GACTGACCAA

GTTTAATTGA

AAGT]'CTAG

TGAATCACGT

TTTTTCCTGT

AGGTGGACAT TCATCTGTTT CCACTGAGTC

AGACTTTT

TATTGTACAG

CTTATTTATA

TTGCTGTATG

AAAGCTAGAA

TCTTAAGACG

GAAATGCTGG TTTTTCAG117 TTC.TTAATAA AAG.TACATGT TTATACGATA AATAACTTTT TI=rATTGC TTGTTGGATT TAAATTT7TTT TTGTTTCATA TCTCGTGGTA GGACTGTAGA ATGATCCCCA GCTGTTTATG TGATTGCT GTAGAAGATG TTCAGGAGTG GGTTGATTTC TAAACTTACT TAGTGTTATG ATTTATGGTA TGCAAAGCAC GATAGATTCT GCTTCTGTTA CTTGGTTAAA GGCATGTAGT AAGCCTTCAC CAC1TJTAAAT CATCTTTCAG AGGATAAGCA CTTGGCTA GTAGAAGACA AATATTTTAC TTACCCCTTA AGGAAACGGA GGCACAGAAA TAAACCAGGT AACATGACTT GGCCAGCCAG CACCTATFTTG

AAAGTAATAC

TCACAACTCT

GCCTAAGTAA

AACGAATCTG

TATGAAAGGT

TGTATAAAGA AGAAAAGGTA TGCAGTCGTG TTTGGATTTT ACTCCACCAT C-3' (FRAG. NO:j (SEQ. ID NO: 2463) CD-34 Nucleic Acids and Antisense Oligonucleotide Fragments 5'-AGGATGATGG TGATGGGGAA CTAAATGGGG AAATATGGAA GGTCACAGGA AAAGTTAACA CAAGTTAGCA AAAGUTAAC ATAACACAAA AAGGTCTTGC AGGAAAAAAA AAAGAAAAGA AAAGAAAGAA AAAGTCTCCA AGAATGGTTT GGACAGCCAA AATGAATACT TATAGTCACG TATACCTGCT CACTCCTGAC GCTTCACTCA CACACAGGAC AGGATCTGGT GAGGCTATCA TAAATGTGC CACATTGTGG TTAAGTTTTA CCTGAT17AAC GAAATGCTCA CACTTCTAAA CTGAGGTCCT TACAGTAGAT TCCTTGCA AGATTGTTAC TGGCT-rACAA CTTAAAAATA AAGGAAAATC ACAAGGAAAG AAAAGTGGGG AAAAAATCGG AGGAAACTTG CCCCTGCCCT GGCCACCGGC AAGGCTGCCA CAAAGGGGTT AAAAGTTAAG TGGAAGTGGA GCUTGAAGAA GTGGGATGGG GCCTCTCCAG GAAAGCTGAA CGAGGCATCT GGAGCCCGAA CAAACCTCCA CCITITFTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCMTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGCAGGGCC CAGGATGCCG CGGGGCTGGA CCGCGC1TTG CTTGCTGAGT TTGCTGC CCTITITITrGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCT17GGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGAGGGCCC CGCGC17TGC TTGCTGAGTT TGCTGCCTrC TGGGTTCATG AGTCTTGACA GAGTTACCTA CCCAGGGAAC ATTTTCAAAT GTTTCTACAA ATGTATCCTA GTACCCTTrGG AAGTACCAGC CTGCACCCTG TGTCTCAACA TGGCAATGAG AACGACAGTC AAATTCACAT CTACCTCTGT GATAACCTCA GTTrATGGAA TCACAGACCT CTGTAATCAG CACAGTGTTC ACCACCCCAG CCAACGTTTC AGCCTAGCCT GTCACCTGGA AATGTTTCAG ACC1TTTCAAC CACTAGCACT TAAACCCTAT ACATCATCTTr CTCCTATCCT AAGTGACATC AAGGCAGAAA GAAGTGAAAT TGACTCAGGG CATCTGCCTG GAGCAAAATA AGACCTCCAG ACAGGGGAGA GGGCCTGGCC CGAGTGCTGT GTGGGGAGGA GCAGGCTGAT ATGCTCCCTG CTCCTTOCCC AGTCTGAGGT GAGGCCTCAG TGTCTACTGC GAAATTTCCA GCAAACTCCA ACTFATGAAA AAGCACCAAT CTGACCTGAA TCACTGAGCA AGATGTTGCA AGCCACCAGA GCTA'ITCCCA AAAGACCCTG AGGATGCCGC GGGGCTGGAC ACAACGGTAC TGCTACCCCA CCAAGAAACT ACAACACCTA GCCACAACAA ACATCACAGA ACACAAACTC YJTCTGTCCAG AACTCCAGAG ACAACCTTGA AGCCTTGCAA CATCTCCCAC TCAAATGTTC AGGCATCAGA CTGTGCGGAG TTTAAGAAGG GCTGATGCTG GGGCCCAGGT TGGTCTTGGC CAACAGAACA AAAGCTGGGG ATCCTAGATT ATTGCACTGG TCACCTCGGG AGCCCTGCTG GCTGTCTTGG GCATCACTGG CTATTTCCTG ATGAATCGCC GCAGCTGGAG CCCCACAGGA GAAAGGCTGG GCGAAGACCC TrATrACACG GAAAACGGTG GAGOCCAGGG CTATAGCTCA GGACCTGGGA CCTCCCCTGA GGCTCAGGGA AAGGCCAGTG TGAACCGAGG GGCTCAGAAA AACGGGACCG GCCAGGCCAC CTCCAGAAAC GGCCATTCAG CAAGACAACA CGTGGTGGCT GATACCGAAT TGTGACTCGG CTAGGTGGGG CAAGGCTGGG CAGTGTCCGA GAGAGCACCC CTCTCTGCAT CTGACCACGT GCTACCCCCA TGCTGGAGGT GACATCTCT-r ACGCCCAACC CTrCCCCACT GCACACACCT CAGAGGCTGT TCTTGGGGCC CTACACCYI7G AGGAGGGGGC AGGTAAACTC CTGTCCTTJA CACATTCGGC TCCCTGGAGC CAGACTCTGG TCT-rCTTTGG GTAAACGTGT GACGGGGGAA AGCCAAGGTC TGGAGAAGCT CCCAGGAACA ATCGATGGCC TFTGCAGCACT CACACAGGAC CCCCTTrCCCC TACCCCCTCC TCTCTGCCGC AATACAGGAA CCCCCAGGGG AAAGATGAGC YTITTCTAGGC TACAA1TTI1C TCCCAGGAAG CTTTGATr TACCGTTTCT TCCCTGTAT-r TTCTTTCTCT ACTTTGAGGA AACCAAAGTA ACC1TTGCA CCTGCTCTCT TGTAATGATA TAGCCAGAAA AACGTGTTGC c1TGAACCAC TTCCCTCATC TCTCCTCCAA GACACTGTOG ACTTGGTCAC CAGCTCCTCC CT-rGTTCTCT AAGTTCCACT GAGCTCCATG TGCCCCCTCT ACCAlTTCA GAGTCCTGCA CAGT1TTCTG GCTGGAGCCT AGAACAGGCC TCCCAAGTTT TAGGACAAAC AGCTCAGTTC TAGTCTCTCT GGGGCCACAC AGAAACTCTT TTrTGGGCTCC TTTTCTCCC TCTGGATCAA AGTAGGCAGG ACCATGGGAC CAGGTCTTGG AGCTGAGCCT CTCACCTGTA CTCTJTCCGAA AAATCCTCUT CCTCTGAGGC TGGATCCTAG CCTTATCCTC TGATCTCCAT GGCTTCCTCC TCCCTCCTGC CGACTCCTGG GTTGAGCTGT TGCCTCAGTC CCCCAACAGA TGcT1TTcTG 305 TCTCTGCCTC CCTCACCCTG AGCCCCT-rCC TTGCTCTGCA CCCCCATATG GTCATAGCCC AGATCAGCTC CTAACCCTTA TCACCAGCTG CCTCTTCTGT GGGTGACCCA GGTCCTTGTT TGCTGTTGAT TJTC'FfTCCAG AGGGGTTGAG CAGGGATCCT GGTTTCAATG ACGGTTGGAA ATAGAAATTT CCAGAGAAGA GAGTATTGGG TAGATA'FfTT TTCTGAATAC AAAGTGATGT GTITTAAATAC TGCAATrAAA GTGATACTGA AACAC-3' (FRAC.No:_J (SEQ. ID NO:2466) TGATGGGGAA CTAAATGGGG AAATATGGAA GGTCACAGGA AAAGTTAACA CAAGTTAGCA AAAAGTTAAC ATAACACAAA AAGGTCTTGC AGGAAAAAAA AAAGAAAAGA AAAGAAAGAA AAAGTCTCCA AGAATGGTTT GGACAGCCAA AATGAATACT TATAGTCACG TATACCTGCT CACTCCTGAC GCTfCACTCA CACACAGGAC AGGATCTGGT GAGGCTATCA CTAAATGTGC CACATTGTGG TTAAGTTTTA CCTGATTAAC GAAATGCTCA CACTTCTAAA CTGAGGTCCT TACAGTAGAT TCCTTTTGCA AGATTGTTAC TGGCU-ACAA CT-rAAAAATA AAGGAAAATC ACAAGGAAAG AAAAGTGGGG AAAAAATCGG AGGAAACTTG CCCCTGCCCT GGCCACCGGC AAGGCTGCCA CAAAGGGGTT AAAAGTTAAG TGGAAGTGGA GCTrGAAGAA GTGGGATGGG GCCTCTCCAG GAAAGCTGAA CGAGGCATCT GGAGCCCGAA CAAACCTCCA CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTFGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGCAGGGCC CAGGATGCCG CGGGGCTGGA CCGCGCTTTG CTITGCTGAGT TTGCTGC-3' (FRAG. (SEQ. ID NO:2464) CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGAGGGCCC AGGATGCCGC AGTCTTGACA ACAACGGTAC ATGTATCCTA CCAAGAAACT TGGCAATGAG GCCACAACAA GTT-FATGGAA ACACAAACTC CCAACGTITC AACTCCAGAG CACTAGCACT AGCCTTGCAA AAGGCAGAAA TCAAATGTTC AGACCTCCAG CTGTGCGGAG GCAGGCTGAT GCTGATGCTG TGTCTACTGC TGGTCYJ7GGC CTGACCTGAA AAAGCTGGGG AAAGACCCTG ATTGCACTGG ATGAATCGCC GCAGCTGGAG GAGOCCAGOG CTATAGCTCA GGCTCAGAAA AACGGGACCG GATACCGAAT TGTGACTCGG GGGGCTGGAC CGCGCT-rTGC TTGCTGAGTT TGCTGCCT-FC TGGGTTCATG TGCTACCCCA GAGTTACCTA CCCAGGGAAC ATTCAAAT GTTrCTACAA ACAACACCTA GTACCCUTGG AAGTACCAGC CTGCACCCTG TGTCTCAACA ACATCACAGA AACGACAGTC AAATTCACAT CTACCTCTGT GATAACCTCA TTCTGTCCAG TCACAGACCT CTGTAATCAG CACAGTGTTC ACCACCCCAG ACAACCTrGA AGCCTAGCCT GTCACCTGGA AATG1TTCAG ACCTTCAAC CATCTCCCAC TAAACCCTAT ACATCATCTT CTCCTATCCT AAGTGACATC AGGCATCAGA GAAGTGAAAT TGACTCAGGG CATCTGCCTG GAGCAAAATA T-rTAAGAAGG ACAGGGGAGA GGGCCTGGCC CGAGTGCTGT GTGGGGAGGA GGGCCCAGGT ATGCTCCCTG CTCCTITGCCC AGTCTGAGGT GAGGCCTCAG CAACAGAACA GAAATT-rCCA GCAAACTCCA ACTTATGAAA AAGCACCAAT ATCCTAGATF TCACTGAGCA AGATGTTGCA AGCCACCAGA GCTATITCCCA TCACCTCGGG AGCCCTGCTG GCTGTCTTrGG GCATCACTGG CTATTTCCTG CCCCACAGGA GAAAGGCTGG GCGAAGACCC YI7ATTACACG GAAAACGGTG GGACCTGGGA CCTCCCCTGA GGCTCAGGGA AAGGCCAGTG TGAACCGAGG GCCAGGCCAC CTCCAGAAAC GGCCATTCAG CAAGACAACA CGTGGTGGCT CTAGGTGGGG CAAGGCTGGG CAGTGTCCGA GAGAGCACCC CTCTCTGCAT TGCTGGAGGT GACATCTCTT ACGCCCAACC CTrCCCCACT GCACACACCT CTACACCTTG AGGAGGGGGC AGGTAAACTC CTGTCC1TTTA CACATTCGGC TC'ITCTrTGG GTAAACGTGT GACGGGGGAA AGCCAAGGTC TGGAGAAGCT TTGCAGCACT CACACAGGAC CCCCT-rCCCC TACCCCCTCC TCTCTGCCGC

CTGACCACGT

CAGAGGCTGT

TCCCTGGAGC

CCCAGGAACA

AATACAGGAA

TACCG'FrTCT

TGTAATGATA

ACTTGGTCAC

GAGTCCTGCA

TAGTCTCTCT

ACCATGGGAC

TGGATCCTAG

TGCCTCAGTC

CCCCCATATG

GGTCC'I17GTT

ATAGAAAT

GCTACCCCCA

TCYI7GGGGCC

CAGACTCTGG

ATCGATGGCC

CCCCCAGGGG

TCCCTGTA~r

TAGCCAGAAA

CAGCTCCTCC

CAGTTTTCTG

GGGGCCACAC

CAGGTCTTGG

CCTTATCCTC

CCCCAACAGA

GTCATAGCCC

AAAGATGAGC TTTTCTAGGC TACAATTrC TTCTJ7TCTCT ACYJ7TGAGGA AACCAAAGTA AACGTGTTGC CTTGAACCAC T-TCCCTCATC CTI7GTTCTCT

GCTGGAGCCT

AGAAACTCTT

AGCTGAGCCT

TGATCTCCAT

TGCTTCTG

AGATCAGCTC

AAGTTCCACT

AGAACAGGCC

1TGGGCTCC

CTCACCTGTA

GGCTTCCTCC

TCTCTGYCCTC

CTAACCCTrFA

GAGCTCCATG

TCCCAAGTTT

FTT7CTCCC

CTCTTCCGAA

TCCCTCCTGC

CCTCACCCTG

TCACCAGCTG

TCCCAGGAAG

ACCYITTTGCA

TCTCCTCCAA

TGCCCCCTCT

TAGGACAAAC

TCTGGATCAA

AAATCCTCT[

CGACTCCTGG

AGCCCCTTCC

CCTCT'TCTGT

GGTITCAATG

AAAGTGATGT

CTTTGATTTT

CCTGCTCTCT

GACACTGTGG

ACCA1TI7GCA AGCTCAGYJ7C

AGTAGGCAGG

CCTCTGAGGC

G'rrGAGCTGT

TUGCTCTGCA

GGGTGACCCA

ACGGTTGGAA

GTTTAAATAC

TGCTGTTGAT TTC1TTCCAG AGGGGTTGAG CAGGGATCCT CCAGAGAAGA GAGTATTGGG TAGATATTTT TTCTGAATAC TGCAATTAAA GTGATACTGA AACAC-3' (FRAG. (SEQ. ID NO:2465) Eotaxin Antisense Nucleic Acids and Oligonucleotide Fragments AAGTTATG ATTTATTTAA GCCAAAGCTC ACACC'I17CAG GCTGCCTTCA GCCCCCAGGG ATAGGAAGAT ACCCCT-rCAG TGTGATCTTC AAGACCAAAC ATGAAGTATC TGGACCAAAA AGCCTGAGTG TGCCTAATT AGGGCATGGG =TTATTATA AGGCTrTAAA ACTTATCCTC

CCTCCAACAT

GCTCGCTGGG

CGACTAGAGA

TGGCCAAGGA

ATCTCCAACT

TGTITTCCCT

TATATATATA

CATGAATATC

CTTGTGGAAC AAAAATAAAC GAAGGTCTCC GCAGCACTTC CCAGCTrCTG TCCCAACCAC GCTACAGGAG AATCACCAGT TATCTGTGCC GACCCCAAGA CCAAAGCCAT AAATAATCAC TCTTACAATG CATTCTGAGG TT~TTIT AAAAAAAAAC AGTTATITJT AAACTGTAAA 306 CAGAAACCAC CACCTCTCAC TGTGGCTGCT GCTCATAGCA CTGCTGCTTT AACCTGGCCA GGCAAATGTC CCCAGAAAGC AGAAGTGGGT GCAGGATTCC CATTTTTGAA ACCAAACCAG TAACCTCA'rr ATCAGTCCAA GTAUTGCATT TAAUTTATTG GCTr-TGTGCA GATTCTTTAC CCCCTGGGAG CCCCAATTCG ATCCCCTGTC ACGTGTGGGC AATGTTCCCC CTCTCCTCTC TrCCTCCCTG GAATCTTGTA AAGGTCCTGG CAAAGATGAT CAGTATGAAA ATGTCATTGT TCTTGTGAAC CCAAAGTGTG ACTCATITAAA TGGAAGTAAA TGTTGTTTTA GGAATAC ATGAAGGTCT CCGCAGCACT TCTGTGGCTG CTGCTCATAG CAGCTGCCTT CAGCCCCCAG GGGCTCGCTG GGCCAGCTTC TGTCCCAACC ACCTGCTGCT TTAACCTGGC CAATAGGAAG ATACCCCTTC AGCGACTAGA GAGCTACAGG AGAATCACCA GTGGCAAATG TCCCCAGAAA GCTGTGATCT TCAAGACCAA ACTGGCCAAG GATATCTGTG CCGACCCCAA GAAGAAGTGG GTGCAGGATI' CCATGAAGTA TCTGGACCAA AAATCTCCAA CTCCAAAGCC ATAA CCACATATTC CCCTCCYI'TT CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC CCTCCTACTA GCTTGCCTCT GCTTGACTTC CTAGGATCTG GAATCTGGTC AGCAATCAGG AATCCCTTCA TCGTGACCCC CGCATGGGCA AAGGCTTCCC TGGAATCTCC CACACTGTCT GCTCCCTATA AAAGGCAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA CCAACCCAGA AACCACCACC TCTCACGCCA AAGCTCACAC CTrCAGCCTC CAACATGAAG GTCTCCGCAG GCTGGGCCAG GTAAGCCCCC CAAGAATCTT TACAGACTCA AGAAATGCCT CAACCGTCAC ACATTCAAGA GGGCCGCTGG CTGTCTTACT GTGGGCATGG CACYJ7CTGTG GCTGCTGCTC ATAGCAGCTG CCTTCAGCCC CCAGGGGCTC CAACTCCTTA CAGGAAAGGT AAGGTAACCA CCTCCAGGCT ACTAGGTCAG CTGCAAATTC TCCATTTGAA AAATAGGGAA ACAGGTTTTG TGGGTGGACA ATCCAGTCAC TGGAAGAGCC AGAACTAGAA AGCTCCCGAG TCT1TCCCC GTGCATCC'IT ACCCAGCTAT CCTTACAGTG TTTGGGAATG GGGAATGGCT TGGGCATTTT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA TTAGAAGCTC GGACAGCTIT CAGAGACAGT GGCTAAGAGA AGAACGAGGT CCCAGGGGAT GACACTCTTT GGGAAAGTTA TCTAGGAGAT T[GTTCCATA ACTCAUTTTC TACTGAGTGT ATCGGTCCCA CTGAGCCAGT GCATAGCATG GTAACAAACA

AGTATGYJTAA

CTCTTGAGGT

CCATACTCTG

GTTCTAAATT

ATCTATAATG

GTGGGGGAAC

CTGTGGCTCA

CCAAACAAAA

AAAATTACCA

CAAGCTTTGT

GACAGCATCC

TYfTCTCCTAA

TCTGTTCATT

AAGATACCCC

TGTAAGTAAA

GGAGTCATAG

CCAGCTCCCT

TGGGCCT-17A

TTCGACTCCA

GACTTATT'rr

GTGACAAATT

ATCAATGACT

TATGGGCTCA

ATTGATGGAT

AAAATGACAC

TAACAGAATT

GGCTJTCTGCA

ACTGTGATAA

CCATCACT

GTGGCCAAGA AATGCAAGTC TGACCATCAC ATGGCCACGT CCATACACTC TACAGTAATG TCCAGACACA TAAGACTTCA CTTCCITrTAC AAAGTCATGC AACTAAATTA ACAAAAGTTA C1TI7CTCACT TTTTATACTC AGGATTCTAG ACTGATGGAG AGCAGAAGAA AGCTCTCAGG AGTCTTGCAT GTCTCCTTCT TTAYITGATCA AAACTAATTA TACCTTGTGT CTCAAAACAG AGGATOGAGA AGGTCTTTAT AATGACAGAG CTAGCATTTG ATGAGTCCTC AGTGCACAGG GGAGGATGCT GAGCAGAGGG ATTCTCCCTC CACCTCTCGC TTGGAAATGT CTATGTATCA TCATGTGGCT

TGTACTAAAT

AAGTTGCCAT

AGGCAATGCA

ATGCCTCCAA

ATATTTGGTG

TCACATTGAC

GAAGACACAG

AATTCCT1TGC CATT1TrTTTC

GGCCAATAGG

AAAGCTGTGA

AAGAACTGTG

GTGTTCACTC

ATGGTTrTTAC

TTTTTTCCCC

T-rCAGCGACT

TAAAGTTCAC

ACTCTGATAG

GCCTGGGAGA

AAAATTCAGC TTCTGTCCCA ACCACCTGCT GCTTTAACCT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG CCTCCCCTrAG ACAAAAAAAT AATGTCTAGG GCACAGAGTC TTTGACCTCT ATGGTCCAAT TCATTAATTT TCACAAGTGA TTGCTGTAGT CATATCAAT-r TCTTCAAGTC AAGAGCAAAG AGAGCAGCAA CTAACCCAAG AGTCTCATCC GGCAGATG GTCCTI'AAAT ATTTAGGGTC AAATGGGCAG CCTGAT-rCTC CCCACAGCTT CAAGACCAAA CTGGCCAAGG TGCAGGATTC CATGAAGTAT CTGGACCAAA AATCTCCAAC AACCAAACCA GAGCCTGAGT GTTGCCTAAT TTGYJ7TTCCC TATCAGTCCA AAGGGCATGG GTTTTATTAT ATATATATAT CATTTAATTr ATTGAGGCTT TAAAACTTAT CCTCCATGAA TGCAGATTCT TTACCCCCTG GGAGCCCCAA TTCGATCCCC TCTCTTCCTC CCTGGAATCT TGTAAAGGTC CTGGCAAAGA GAACCCAAAG TGTGACTCAT TAAATGGAAG TAATGTTGTT TTCCTCCTCT CCGTAGCAAC CCTTTGTCCA AA=TTCAAA AACAATCCTT CCAATTGCAT ATATCTGTGC CGACCCCAAG AAGAAGTGGG TCCAAAGCCA TAAATAATCA CCAT'TI'TGA TfCTTACAAT ATATATT1TT

TATCAGTTAT

TGTCACGTGT

TGATCAGTAT

TTAGGAATAC

GCATTCTGAG

TT[TAAAAAA

T1TTTAAACTG

GGGCAATGTT

GAAAATGTCA

ATAAAGTATG

GGGGG-3'

GTAACCTCAT

AAACGTATTG

TAAAGCTTTG

CCCCCTCTCC

TTGTTCTTGT

TGCATA1TT :FRAG.NO:_) ATTATAGTCA CTAGTTGTAA TTTTTTTGTG GGAAATCCAC ACTGAGCTGA (SEQ. ID NO:2494) 5'-GCATTThJ7TC AAGTT~rATG ATTTATTTAA CTTGTGGAAC AAAAATAAAC CAGAAACCAC CACCTCTCAC GCCAAAGCTC ACACCTUCAG GCTGCCTTCA GCCCCCAGGG ATAGGAAGAT AccccTTrCAG TGTGATCTTC AAGACCAAAC ATGAAGTATC TGGACCAAAA AGCCTGAGTG YrGCCTAATT AGGGCATGGG 1TrrATTATA AGGCTFITAAA AC1TATCCTC CCCCTGGGAG CCCCAATTCG GAATCTTGTA AAGGTCCTGG

CCTCCAACAT

GCTCGCTGGG

CGACTAGAGA

TGGCCAAGGA

ATCTCCAACT

TGT11TTCCCT

TATATATATA

CATGAATATC

ATCCCCTGTC

CAAAGATGAT

GAAGGTCTCC GCAGCACTTC TGTGGCTGCT CCAGCTTrCTG TCCCAACCAC CTGCTGCTTT GCTACAGGAG AATCACCAGT GGCAAATGTC TATCTGTGCC GACCCCAAGA AGAAGTGGGT CCAAAGCCAT AAATAATCAC CATTMGAA TCTTACAATG CATITCTGAGG TAACCTCATr TTTTTFrT AAAAAAAAAC GTATTGCATT AGT[ATTTT AAACTGTAAA GCTTGTGCA ACGTGTGGGC AATGTTCCCC CTCTCCTCTC CAGTATGAAA ATGTCAT-rGT TCTTGTGAAC

GCTCATAGCA

AACCTGGCCA

CCCAGAAAGC

GCAGGATTCC

ACCAAACCAG

ATCAGTCCAA

TAAT1TrAT1'G

GATTCTTTAC

TI7CCTCCCTG

CCAAAGTGTG

ACTCAT-rAAA TGGAAGTAAA TGTTGTIrTAGGAATAC-3' (FRAG.NO:_) (SEQ. ID NO:2491) -ATGAAGGTCT CCGCAGCACT TCTGTGGCTG CTGCTCATAG CAGCTGCCTT CAGCCCCCAG GGGCTCGCTG GGCCAGCTTrC TGTCCCAACC ACCTGCTGCT TTAACCTGGC CAATAGGAAG ATACCCCT-rC AGCGACTAGA GAGCTACAGG AGAATCACCA GTGGCAAATG TCCCCAGAAA GCTGTGATCT TCAAGACCAA ACTGGCCAAG GATATCTGTG CCGACCCCAA GAAGAAGTGG GTGCAGGATT CCATGAAGTA TCTGGACCAA AAATCTCCAA CTCCAAAGCCATAA-3' (FRAG. (SEQ. ID NO:2492) -CCACATATTC CCCTCCTITT CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC CCTCCTACTA GCTTGCCTCT CTITCTGTITCT GCT-rGACTTC CTAGGATCTG GAATCTGGTC AGCAATCAGG AATCCCITrCA TCGTGACCCC CGCATGGGCA AAGGCTTCCC TGGAATCTCC CACACTGTCT GCTCCCTATA AAAGGCAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA CCAACCCAGA AACCACCACC TCTCACGCCA AAGCTCACAC 307 CT-rCAGCCTC

CCAGGGGCTC

ACTAGGTCAG

TGGGTGGACA

TCTTITcccc

GGGAATGGCT

YJTAGAAGCTC

CCCAGGGGAT

ACTCAT[TTC

GTAACAAACA

TGTACTAAAT

AAGTTGCCAT

AGGCAATGCA

ATGCCTCCAA

ATATTTFGGTG

TCACATTGAC

CAACATGAAG GTCTCCGCAG GCTGGGCCAG GTAAGCCCCC CAAGAATCTT TACAGACTCA AGAAATGCCT CAACCGTCAC ACATTCAAGA GGGCCGCTGG CTGTCTTACT GTGGGCATGG AGTATGTTAA TTCGACTCCA CTCTTGAGGT GACTTATTTT CCATACTCTG GTGACAAATT GTTCTAAATT ATCAATGACT ATCTATAATG TATGGGCTCA GTGGGGGAAC ATTGATGGAT CTGTGGCTCA AAAATGACAC CCAAACAAAA GTGGCCAAGA AAAATTACCA TGACCATCAC CAAGCTYJ7GT CCATACACTC

CACTTCTGTG

CAACTCC17A

CTGCAAATTC

ATCCAGTCAC

GTGCATCCTT

TGGGCATfTTT JiGACAGCT1T GACACTCTTr

TACTGAGTGT

GCTGCTGCTC

CAGGAAAGGT

TCCATTI'GAA

TGGAAGAGCC

ACCCAGCTAT

TGGCAGTGGG

2AGAGACAGT

GGGAAAGTTA

ATCGGTCCCA

ATAGCAGCTG CCTTCAGCCC AAGGTAACCA CCTCCAGGCT AAATAGGGAA ACAGGTTTTG AGAACTAGAA AGCTCCCGAG CCTTACAGTG TUTGGGAATG AGAGAAGGAA AATCTGTTGA GGCTAAGAGA AGAACGAGGT TCTAGGAGAT TTGTTCCATA CTGAGCCAGT GCATAGCATG GAAGACACAG GACAGCATCC TCCAGACACA AATTCCUTGC 'FrTCTCCTAA CTTCCTTTAC CATTTTTC TCTGTTrCATT TIT=TCCCC GGCCAATAGG AAGATACCCC Y1rCAGCGACT AAAGCTGTGA TGTAAGTAAA TAAAGTTCAC AAGAACTGTG GGAGTCATAG ACTCTGATAG GTGTTCACTC CCAGCTCCCT GCCTGGGAGA ATGGT1TTAC TGGGCCTTTA AGAGCAGCAA CCTTTGTCCA GGGGCAGATG GTCCTTAAAT CCAATTGCAT CCTGAU-CTC CCCACAGCTT AAGAAGTGGG TGCAGGA11TC CATGAAGTAT TAACAGAATT AACTAAATTA ACAAAAGTTA CTTTCTCACT GGCTTCTGCA 1TTATACTC AGGATTGTAG ACTGATGGAG ACTGTGATAA AGCAGAAGAA AGCTCTCAGG AGTCTTGCAT CCATCACT GTCTCCTTCT TTATTGATCA AAACTAATTA AATGCAAGTC TACCYJ7GTGT CTCAAAACAG AGGATOGAGA ATGGCCACGT AGGTCTrI'AT AATGACAGAG CTAGCATTTG TACAGTAATG ATGAGTCCTC AGTGCACAGG GGAGGATGCT TAAGACTTCA GAGCAGAGGG A117CTCCCTC CACCTCTCGC AAAGTCATGC TTGGAAATGT CTATGTATCA TCATGTGGCT kLAAATTCAGC TTCTGTCCCA ACCACCTGCT GCTTTAACCT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG CCTCCCCTAG ACAAAAAAAT AATGTCTAGG GCACAGAGTC ITGACCTCT ATGGTCCAAT TCATTAATIT TGACAAGTGA TTGCTGTAGT CATATCAATT TCTTCAAGTC AAGAGCAAAG CTAACCCAAG AGTCTCATCC TTCCTCCTCT CCGTAGCAAC AT7AGGGTC AAATGGGCAG AAT-fTTCAAA AACAATCC1T >AAGACCAAA CTGGCCAAGG ATATCTGTGC CGACCCCAAG CTGGACCAAA AATCTCCAAC TCCAAAGCCA TAAATAATCA GTTGCCTAAT TTGTTTTCCC TTC'rrACAAT GCATTCTGAG GTMTATTAT ATATATATAT ATATATT1TT TTI7AAAAAA TAAAACTTAT CCTCCATGAA TATCAGTTAT TTTTAAACTG GGAGCCCCAA TTCGATCCCC TGTCACGTGT GGGCAATGTT GTAAAGGTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA TAAATGGAAG TAATGTTGTT TTAGGAATAC ATAAAGTATG

CCATTTTTGA

GTAACCTCAT

AAACGTATTG

TAAAGCTTTG

CCCCCTCTCC

'rrGTTCTTGT

TGCATATT[

(FRAG.NO:)

AACCAAACCA

TATCAGTCCA

CAT-FTAATY[

TGCAGATTCT

GAGCCTGAGT

AAGGGCATGG

ATFGAGGCTT

TrACCCCCTG TCTCTTCCTC CCTGGAATCT I GAACCCAAAG TGTGACTCAT ATTATAGTCA CTAGTTGTAA TTFTTTGTG GGAAATCCAC ACTGAGCTGA GGGGG-3' (SEQ. ID NO:2493) FK-506 Binding Protein Nucleic Acids and Oligonucleotide Fragments GCCAGGTCGC TGTTGGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC CGCCATGGGA GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG GGCCTGTGGG ACCGCTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC ATFCCCCAAG AAGGGCCAAA CGTGTGTGGT GCACTACACA GGAATGCTCC AAAATGGGAA GAAGTTTGAT TCATCCAGAG ACAGAAACAA ACCT17TCAAG TTCAGAATTG GCAAACAGGA AGTCATCAAA GGITTTGAAG AGGGTGCAGC CCAGATGAGC TITGGGGCAGA GGGCGAAGCT GACCTGCACC CCTGATGTGG CATATGGAGC CACGGGCCAC CCCGGTGTCA TCCCTCCCAA TGCCACCCTC ATCTTTGACG TGGAGCTGCT CAACTTAGAG TGAAGGCAGG AGATGGCTGC TGCTCACCCT AGTGTGCTAA CCTCACTGiCC AGTGTTCATG CGAATTCTTG TGTGATGCAT GTAGTAGCCT ACCF!TCACTT AAACCACACA CT-rGAGCCAG TTACCTTTGC CTCYFTGAGA AAATGTAAAA TCCACGCCGC CCGTCGCGCC CCTAGCCTGC TCTGCCACTG TCATGGCATC ATCCATTCTC CUTGAGGAAA CTI'CGGTTGC TTCCTGATGA CAGAACACAG CACAAGGTGC TCAGACATGA TGTCACTITTC TCTCTTATAA TAAAGGCTCT GTGCTTGACA

GGACGGCTCC

TCTGCCCAAG

AGATTGAAGC

ATCTCTTG1TT

AATGTACATG

ATTCTGT7AG

AAGGAACTCA

TGCTTTTGGG

TTGCTCTGTA

AT[TCAGGTT

CGCACAATCT

GCGTACCGTA

CTGCTCACTT

AGGTGGCTGG

GCTCTTGATC

TGTGTTCGTC

GTGCATTTTG

ACACTGCCTT

CACAGAGGGA

AAACAATGTC

GAATTCGGGC CGCCGCCAGG TCGCTGTTGG GCCCGCCCGC TCAGCGTCCG CCGCCGCCAT GGGAGTGCAG GTGGAAACCA

TCTCCCCAGG

TGAAGATGGA

GAGGTGATCC

CTCCAGATTA

TGTGGAGCT7

GGAGGGATCT

1TTTGTATAGA crccccrr

TFGTTTTCAT

AAGTATTAAC

ATATTTTATT

AAAGCCATAG

AAATTAAAAG

CTCCCCT1TAA AGACGGGCGC ACCTTCCCCA AGCGCGGCCA AAGAAATTTG ATTCCTCCCG GGACAGAAAC GAGGCTGGGA AGAAGGGGTT GCCCAGATGA TGCCTATGGT GCCACTGGGC ACCCAGGCAT CTAAAACTGG AATGACAGGA ATGGCCTCCT GGTGCCTCCA GACATGTGCA CATGAGTCCA CATCTGCCCT GACTGAATGT GUrCTGTCAC CTCCTCGTAT GTGTG1TTTAC CTAAACTATA TTTGGGGTGA AGATTCAGTT TCAGTCTT1T AGCACAAGTG GTAGGTTAAC ATTAGAATAG TTAA1TTTT GGATGAAATT 1TrATCTATT CAGATGAG GCGCTGTTGA GGACTGAATT CCCTACCTAA AACTGAGGTG GGGATGGGGA ACCCTCTGCC YTrGAAAGTA GATCATGTTC

GACCTGCGTG

AAGCCCT~rA

GTGTGGGTCA

CATCCCACCA

CCCT-rAGCTC

TATGGAGCTT

TCAGCTTTGC

TGCCATAAAC

GGATATAGGT

GAATJ7GGTGT

ATATATTAAA

ACTCTCCAAG

GAGCCTrGC

ACTGCAATGC

GTGCACTACA

AG1TATGCT

GAGAGCCAAA

CATGCCACTC

CCTGTTCTTG

T-rCCTGATGT TI7CCGACACC

CTCAAGTTAT

TTCCAATTAA

TGGGGGGGGG

CATTCTTGCT

TTGAGAGATG

CTCCACCATT

TGGACACTAC

CCGGGATGCT

AGGCAAGCAG

CTGACTATAT

TCGTCITCGA

GATCTGCCAT

TCCACTCCAC

TCTGTTTCCT

TCATI=ATT

GTACATGGTC

GTTTGCAAGA

GCTGCGCTGC

TCTGGGTT

CCCACCCACC

AGGTATCTGT

GGTITCTA CCCTGGGCCA GCAGGGACCT CTGAAGCCTT CTTGTGGCC TTTTTTTT TTCATCCTGT 308

ATGGACTTTC

AATTGACAGT

ATCCTITGAAT

TGGCTCCCTC

GTGTAGTGAT

TATTGCAATA

GAGACGGGCG

AAAGAAATTT

CGAGGCTGGG

ATGCCTATGG

TCTAAAACTG

TGGTGCCTCC

ACATCTGCCC

AGGAATTTTG TAATCTCATA ACMICCAAG CTCCACCACT TCCTAAATCT TAAGAACTf TfCAA11'GAA GGTGCTGT GTAGACTTAA CACCCAGTGA AAGCCCAGCC ATCATGACAA G11TCTCTTAA GAAAATGATG CTGGTCATCG CAGCUTCAGC ATCTCCTGTf TTTTGATGCT TGCTGATCTC AGTTTCCTGG CTMTCCTCC CTCAGCCCCT TCTCACCCCT TTGCTGTCCT TTGGTGAGAA ATCGTTGCTG CACCCTTFCCC CCAGCACCAT TTATGAGTCT CAAGTTrTAT AAAGTGCTTT ATGCCCGAAT TC GCCGCCGCCA TGGGAGTGCA GGTGGAAACC ATCTCCCCAG CACCTTCCCC AAGCGCGGCC GATTCCTCCC GGGACAGAAA AAGAAGGGGT TGCCCAGATG TGCCACTGGG CACCCAGGCA GAATGACAGG AATGGCCTCC AGACATGTGC ACATGARTCC TGACTGAATG TGTTCTGTCA AGACCTGCGT GGTGCACTAC ACCGGGATGC UTGAAGATGG CAAGCCCTTT AAGTTTATGC TAGGCAAGCA GGAGGTGATC AGTGTGGGTC AGAGAGCCAA ACTGACTATA TCTCCAGATr TCATCCCACC ACATGCCACT CTCGTCTTCG ATGTGGAGCT TCCCTTAGCT CCCTGTTCTT GGATCTGCCR TGGAGGGATC ATATGGAGCT TTTCCTGATG TTCCACTCCA CTTTGTATAG CTCAGCTT[G CTTCCGACAC CTCTGTTTCC TCTrCCCCTr TCTCCTCGTA TGTGTGTTTA CCTAAACTAT ATGCCATAAA CCTCAAGTTA TfCA-3' (FRAG. (SEQ.

ID NO:2499) GCCAGGTCGC TGTITGGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC CGCCATGGGA-3' (FRAG. No:_J(SEQ. ID NO: 2495) -GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG GGCCTGTGGG CCGCTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC ATTCCCCAAG AAGGGCCAAA CGTGTGTGGT

OCACTACACA

TTCAGAATTG

GGGCGAAGCT

TGCCACCCTC

AGATOOCTGC

AGTGTGCTAA

AGTGTTCATG

TGTGATGCAT

GGAATGCTCC AAAATGGGAA GAAGTTTGAT TCATCCAGAG ACAGAAACAA GCAAACAGGA AGTCATCAAA GGTITFGAAG AGGGTGCAGC CCAGATGAGC GACCTGCACC CCTGATGTGG CATATGGAGC CACGGGCCAC CCCGGTGTCA ATCTTTGACG TGGAGCTGCT CAACTTAGAG TGAAGGCAGG AAGGAACTCA TGCTCACCCT CCTAGCCTGC TCTGCCACTG GGACGGCTCC TGCTTTTGGG CCTCACTGCC TCATGGCATC ATCCATTCTC TCTGCCCAAG TTGCTCTGTA CGAATTCTTG CTTGAGGAAA CTTCGGTTGC AGATTGAAGC ATTTCAGGTT GTAGTAGCCT TTCCTGATGA CAGAACACAG ATCTCTTGTT CGCACAATCT ACC11TTCAAG

TTGGGGCAGA

TCCCTCCCAA

AGGTGGCTGG

GCTCTTGATC

TGTGYrCGTC GTGCATrTTG

ACACTGCCTT

ACCTTCACTT AAACCACACA CACAAGGTGC TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA CTTGAGCCAG TTACC~rTGC TGTCACTC TCTCTTATAA ATTCTGTTAG CTGCTCACTfr AAACAATGTC CTC'FfGAGAAAATGTAAAATAAAGGCTCTGTGCTTGACA-3' (FRAG. (SEQ. ID NO:2496) -GAATTCGGGC CGCCGCCAGG TCGCTGTTGG TCCACGCCGC CCGTCGCGCC GCCCGCCCGC TCAGCGTCCG

CCGCCGCCAT

GACCTGCGTG

AAGCCCTrTA

GTGTGGGTCA

CATCCCACCA

CCCTTAGCTC

TATGGAGCTrr

TCAGCTTTGC

TGCCATAAAC

GGATATAGGT

GAATTGGTGT

ATATATTAAA

ACTCTCCAAG

GAGCCTTTGC

ACTGCAATGC

rr7TTTTT

CTCCACCACT

CACCCAGTGA

CAGCTTCAGC

CTCAGCCCCT

GGGAGTGCAG GTGGAAACCA TCTCCCCAGG AGACGGGCGC GTGCACTACA CCGGGATGCT TGAAGATGGA AAGAAATTTG AGT11TATGCT AGGCAAGCAG GAGGTGATCC GAGGCTGGGA GAGAGCCAAA CTGACTATAT CTCCAGATTA TGCCTATGGT CATGCCACTC TCGTCTTCGA TGTGGAGCTT CTAAAACTGG CCTGTTCTTG GATCTGCCAT GGAGGGATCT GGTGCCTCCA TTCCTGATGT TCCACTCCAC UTTGTATAGA CATCTGCCCT TTCCGACACC TCTGTTTCCT CTVCCCC'IM CTCCTCGTAT CTCAAGTTAT TCATTTTATT YI'GTTTTrCAT TTTGGGGTGA TTCCAA11TAA GTACATGGTC AAGTATTAAC AGCACAAGTG TGGGGGGGGG GTTTGCAAGA ATATTTTATT TfTAATTTflTT CATTC11TGCT GCTGCGCTGC AAAGCCATAG CAGATTTGAG TTGAGAGATG TCTTTGGGTT AAAITAAAAG CCCTACCTAA CTCCACCATT CCCACCCACC CTCCCCTT7AA ACCCTCTGCC TGGACACTAC AGGTATCTGT CCCTGGGCCA GCAGGGACCT TTCATCCTGT GGTrTTTTCTA ATGGAC=rC AGGAATTTTG TCCTAAATCT TAAGAACTTT AATTGACAGT TTCAATTGAA AAGCCCAGCC ATCATGACAA ATCCTTGAAT G~rCTC'rrAA ATCTCCTGTT 1TFGATGCT TGGCTCCCTC TGCTGATCTC TCTCACCCCT TTGCTGTCCT GTGTAGTGAT TITGGTGAGAA ACCUTCCCCA AGCGCGGCCA AT1TCCTCCCG GGACAGAAAC AGAAGGGGTT GCCCAGATGA GCCACTGGGC ACCCAGGCAT AATGACAGGA ATGGCCTCCT GACATGTGCA CATGAGTCCA GACTGAATGT GTTCTGTCAC GTGTGTTTAC CTAAACTATA AGATTCAGTT TCAGTCTTT GTAGGTTAAC ATTAGAATAG GGATGAAATT T'ITATCTATT GCGCTGTTGA GGACTGAATT AACTGAGGTG GGGATGGGGA TIFTGAAAGTA GATCATGTTC CTGAAGCCTT CTTTGTGGCC TAATCTCATA ACTTTCCAAG GGTGCTGTTT GTAGACTTAA GAAAATGATG CTGGTCATCG AGTTTCCTGG CTT-7TCCTCC ATCGTTGCTG CACCCTTCCC CCAGCACCAT TI1ATGAGTCT CAAGTTTI7AT TA11'GCAATA AAAGTGCT ATGCCCGAAT TC-3' (FRAG.NO:_J (SEQ. ID NO:2497) GCCGCCGCCA TGGGAGTGCA GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCTTCCCC AAGCGCGGCC AGACCTGCGT GGTGCACTAC ACCGGGATGC UTGAAGATGG AAAGAAATTT GATTCCTCCC GGGACAGAAA CAAGCCCYIT AAGTTTATGC TAGGCAAGCA GGAGGTGATC CGAGGCTGGG AGTGTGGGTC AGAGAGCCAA ACTGACTATA TCTCCAGATT ATGCCTATGG TCATCCCACC ACATGCCACT CTCGTCTTCG ATGTGGAGCT TCTAAAACTG TCCCTrAGCT CCCTGTTCTr GGATCTGCCR TGGAGGGATC TGGTGCCTCC ATATGGAGCT YTrCCTGATG UTCCACTCCA cTI'GTATAG ACATCTGCCC CTCAGC'rITG CYI7CCGACAC CTCTGTTTCC TC'ITCCCCTT TCTCCTCGTA ATGCCATAAA CCTCAAGTTA TTCA-3' (FRAG. (SEQ. ID NO:2498)

AAGAAGGGGT

TGCCACTGGG

GAATGACAGG

AGACATGTGC

TGACTGAATG

TGTGTGTTTA

TGCCCAGATG

CACCCAGGCA

AATGGCCTCC

ACATGARTCC

TGTTCTGTCA

CCTAAACTAT

wherein B is adenosine, or, more preferably, replaces adenosine and is an "equivame\ \lent" or a "universal" base, and adenosine A2a, receptor agonist or only 309 minimally antagonist, an adenosine A2b receptor antagonist, an adenosine A 3 receptor antagonist, or an adenosine Ai receptor antagonist. Similarly, adenosine may always be replaced by an "alternative", "equivalent" and/or "universal" base having a small fraction, preferably less than 0.3 of the activity of adenosine at the adenosine receptor(s), as described above.

In one preferred embodiment, the links between neighboring mononucleotides are phosphodiester links. In another preferred, at least one mononucleotide phosphodiester residue of the anti-sense oligonucleotide(s) is substituted by a methylphosphonate, phosphotriester, phosphorothioate, phosphorodithioate, boranophosphate, formacetal, thioformacetal, thioether, carbonate, carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, sulfoxide, sulfide, hydroxylamine, 2'-O-methyl, methylene(methyimino), methyleneoxy (methylimino), phosphoramidate residues, and combinations thereof. The oligos having one or more phosphodiester residues substituted by one or more of the other residues are generally longer lasting, given that these residues are more resistant to hydrolysis than the phosphodiester residue. In some cases up to about about 30%, about 50%, about 75%, and even all phosphodiester residues may be substituted (100%).

Typically, the multiple target anti-sense oligonucleotide (oligo) of the invention comprises at least about 7 mononucleotides, in some instances up to 60 and more mononucleotides, preferably about 10 to about 36, and more preferably about 12 to about 21 mononucleotides.

However, other lengths are also suitable depending on the length of the target macromolecule. Examples of the MTA oligos of the invention are provided in Table 3 below, which includes ninety-four sequences (SEQ ID NOS.: 2316 through 2410).

Table 3: MTA Oligos, Location Targeted Target MTA Oligo SEQ. ID Location Compound Target No. Targeted

AS

CCC GGC CCC GCC TCG TGC C 3019 5'=1 EPI 2192 CGT CCB TGC CGC GGG CCC 3020 5'=28(AUG)EPI 2193 310 GCC CCG CTG CTT GGG CTG CTC TGC CGG G

TCT

TGG

CTG

cxT

GGG

TGT

GCC

GGC

GGC

GGG

GGG

GCC

GCT

GTT

TCG CCT GGG TCT TGG TGG CTG TG

TC

GGT CTG G

GC

cc

CGT

GTG GGT CCG CTG TGG CTT GGG G TGG GCC TTG GGG GC CTG TTG CC

GCC

GCT GGG TCG GGG GGC CTC TGG GCT GTC

GCC

TGG

GCT

CGG

GGC

GCC

CCC

CCC

ccc

CCC

CCC

CCC

CCG

ccc

CCC

CCC

CBG

cc cc cc GAG A

TC

cc BCG BEC C

BCG

BCG BBC C

BCG

TCE BG

TC

C

TEG TGC C

C

BEG TGC C CGT GCC 3021 3022 3023 3024 3025 3026 3026 3027 3028 3029 3030 3031 3032 3033 3034 3035 3036 3037 3038 3039 3040 3041 3042 3043 3044 3045 3046 3047 3048 3049 3050 3051 3052 3053 3054 3055 3056 3057 3058 3059 3060 3061 3062 3063 3064 3065 3066 3067 3068 3069 3070 3071 3072 5' =65 5' =137 5'-159 5- 196 5'-362 5'-401 5'-6 56 5' =697 5' =769 5' =953 5'-1022 5' 1208 5' =12 72 5- 1362 1451 5- 1511 5- 1550 5- 17 72 5- 1863 5- 1979 5'-2011 5'-2312 intron intron 5' untr 5' untr trans trans 5'untr 5'I trans 5'1 untr 3' trans intron intron 5' trans 3' trans 2194 2195 2196 2197 2198 2199 2200 2201 2202 2203 2204 2205 2206 2207 2208 2209 2210 2211 2212 2213 2214 2215 2192-01A HSU5O136C4Synth 2192-01B 2192-02A 2192- 02B 2192-03A HSNFKBS Subunit 2192-03B 2192-04 TGFc-&Rl 2192-05A HSU581981l enhan 2192-05B 2192-06 HSVECAD 2192-07A NFKB2 2192-07B NFKB2 2192-08 Carboxypep C CCG CCT CGT GCC CCG GCB CCG CCT CET GCC CCG GCC CCG CCB CET GCC HumADRA2CX(2AdrKid CCC GEC CCC GBC TCG CCC GGC CBC GEC TCG HSNBARKS166-AdrKin CCC GGC CCB GCC TBG CCC GGC BCE GBC TCG TBC C 5'untrs EPI 2192-10 5'untrs EPI 2192-11 5'UTR EPI 2192-12 2192- 09 HUMFK506B HSNFXN1 (NFKB1) CCC GGC CCC GCC ECG CCC GGC CCC GCC ECG TCC ETG CCG CGG GC TCC ETG CCE CGG GCC TCC ETG CCE CGG GCC TCC ETG CCB CEG GCC GTC CET GEC GCG G TC CET GEC GCG GG 3'UTR EPI 2192-13 HSILF(transcrp.

Factor ILF) EPI-2192-14 TGFBrecl MTA EPI -2192 15NFKB/C4Syn/5 -LOMTA 3' trans EPI-2193-01 METOncogene 3' trans EPI-2193-02 HSFGR2(IG) mid cod EPI-2193-03 mid cod EPI-2193-04 HUMTK14 3'trans EPI-2193-05 HUMTNFR AUG Probl.HUMPTCH cardiacK+channel intr EPI-2195-01 humCSPAcytotox.

Ser. Protease intr EPI-2195-02 HSIN'OSX8induc.NOS EPI-2195-03 HUMACHRM2musc.m2 acetyich. rec.

EPI-2195-04 s86371s1 Neurokinin3 Recept EPI-2195-05 HUMMIPi Amacro TCT GEG CTC CTC TEE CCT GG CTG TGC BCC TEE CEC CTG GG TGT GET CCE CTE GEC TGG G TCT GTE CTC EEC TCE CCT G TGC TCC TCE CEE CTG GG inf lam. factor- Table 3: MTA (Cont'I d) MTA Oligo Oligos, Location Targeted Target SEQ. ID 311 Location Compound Target CTC CTC TBG CCT GG Kinase GTG CTC CEB TCB BCT GGG GTG CBC CEB TCE CCT GGG TCT GTG CBC CTC TEG ECT CTG TEE TCC TEE CEC CTG TGT GCT EET CEC ECE TG GTG CEC CEC TCE CCT G CTG TGC BCC TCT C CEG TGC ECC ECT CBC CTG G TGC BCC ECT CEC CTG CEC CTC TCE CCT GGG C CTC TCE CCT GGG GCT CCE CTC 0CC T TGC TCC TCE CGC C GTT GTT GET CTG G GGT TGE EET TGG TCT TOO GOT TGT TGE TGE TCT G GGG TTE EEG TTG ETC TGG No.

3073- 3074 3075 3076 3077 3078 3079 3080 3081 3082 3083 Targeted EPI-2195-06 HSNBARKS4 66--Adr EPI-2195-07 HSTNFR2SO6TNF R2 EPI-2195-08 humfkbp fk506 binding prot.

EPI-2195-09 exon in.

3084 3085 3086 int: 3087 intron EPI-2195-10 EPI-2195-11 tron/exon EPI-2195-12 3'UTR EPI-2203-05 intriex EPI-2203-06A intr/ex EPI-2203-06B coding EPI-2203-07A coding EPI-2203-07B coding EPI-2203-08 ron PDGF A EPI-2303-09 3'utr EPI-2199-01 Coding EPI-2199-02 Far 5'UTR EPI-2199-03 Codino EPI-2199-04 Recept.Kinase HUMI L8 HSUS0157 PDE4 IL-2 R IL-6 Rt HSIL6R HS IL2 rG6 HS IL2 r06 HUMI L7 1 IL-7 HUMIL71 IL-6 Rt HS16REC Chain HUMPDGFAB GATA-4Transcrip.

Factor for TNFX( HUMTNFA HSSUBPlG(Sub Pr) NeutrophilAdh.

Rt HUMNARIA m2 Muscarinic Rt Li LeukAadh-Prot HUMGATA2A IGE eps HSGCSFR2 TGF6 NFKB/bJK TCell 000

TTG

000

GG

000

GGG

000 ETC TGG

TOO

CCG CTG CEO CTG

C

CEO C 000 TOO OCT TOG 0

CCTGGGTGGGEETGGG

CCTGGETGGGCETGGG

GCCTGBGTGEECTTG

3088 3089 3090 3091 3092 3093 3094 3095 3096 3097 3098 3099 3100 3101 3102 3103 3104 3105 3106 3107 3108 3109 3110 HSHM2 EPI-2199-05 HUMLiCAM EPI-2199-06 coding EPI-2203-01 S71424S2 EPI-2203-02 coding EPI-2203-03 HUMITOF EPI-2203-04 HUMNK65PRO EPI-2206-01

CCCAVGVCCVCCCAGGC

AGCCCACCCAGGC

ECCTGGGTOGGCTE

OOTOOGCTTOGGG

CCBEOGTGGGCTTGGG

Activating Prot HUMPEREEB EPI 2206-02 NFKB/Prostagl.

EP3 Rec EPI 2206-03 HSNF2B/GCSF NFKB/GranuLocCSF/ Transcr. FactorNF2B EPI-2206-04 HUMLAP/NFKB3 Leuk .Adhes. Prot EP12206-05 NFKB/Endothel N2 S63833 EPI 2206-06 NFKBAS13/B Lymph SerThrProt.Kinase EP12206-07 NFKBAS13/OCSF1 HSGCSFR1Rec EP12206-08 NFKBAS13/GCSF1/ NK7TCELLACT. Prot EPI 2206-09 NFKB3AS13/ HSTGFB1 TOFB EPI 2206-10 NFKBAS13/ HSTGFB1 TGFB1 EPI 2206-11 NFKBAS13/ HSGCSFR1 GCSFR1 EPI 2206-12 NFKBAS13/HUMCD3OA LymphActAnt igCoding EPI-2206-12B NFKBAS13/HUMCD3OA EPI 2206-13 NFKBAS13/I4UMCAMIV Vasc.Endoth. Cell Adh.Molec

CTGGGTGGGEETGGG

CCEGGGTGGGCTTGG

GGGTGGGCTTGG

CCTGEGTGEGCETGGG

B: Universal Base The MTA oligos of Table 3 are suitable for use with two or more of the targets listed in Table 4 below.

Table 4: Targets for the MTA Oligos Of 312 Table 3 Compound Target EPI 2010 Adenosine Al receptor EPI 2045 Adenosine A3 receptor EPI 2873, EPI NFEB 2193 EPI 1873 Interleukin-1 EPI 1857 Interleukin EPI 2945 Interleukin -4 EPI 2977 Interleukin -8 EPI 2031 EPI 1898 Leukotriene C-4 Synthase EPI 1856 Eotaxin EPI 1131 ICAM EPI 1085 VCAM EPI 2085 TNFX EPI 1908 PAF EPI 1925 IL-4 receptor EPI 2643 6 2 aderenergic receptor kinase EPI 2934 Tryptase EPI 2033 Major Basic Protein EPI 2795 Eosinophil Peroxidase NfIB: nuciear factor SZ ICAM: intracellular adhesion molecule VCAM: vascular cell adhesion molecule TNF: tumor necrosis factor PAF: olatelet activatina factor The mRNA sequence of the targeted protein may be derived from the nucleotide sequence of the gene expressing the protein, whether for existing targets or those to be found in the future. Sequences for many target genes of different systems are presently known.

See, GenBank data base, NIH, the entire sequences of which are incorporated here by reference. The sequences of those genes, whose sequences are not yet available, may be obtained by isolating the target segments applying technology known in the art. Once the sequence of the gene, its RNA and/or the protein are known, anti-sense oligonucleotides are produced as described above and utilized to validate the target by in vivo administration and testing for a reduction of the production of the targeted protein in accordance with standard techniques, and of specific functions. As already described above, the anti-sense oligonucleotides may be of any suitable length, from about 7 to about 60 nucleotides in length, depending on the particular target being bound 313 and the mode of delivery thereof. The anti-sense oligonucleotide preferably is directed to an mRNA region containing a junction between intron and exon or to regions vicinal to the junction. Where the anti-sense oligonucleotide is directed to an intron/exon junction, it may either entirely overlie the junction or may be sufficiently close to the junction to inhibit splicing out of the intervening exon during processing of precursor mRNA to mature mRNA, with the 3' or terminus of the anti-sense oligonucleotide being positioned within about, for example, 10, 5, 3, or 2 nucleotide of the intron/exon junction. Also preferred are anti-sense oligonucleotides which overlap the initiation codon and, more generally, those that target the coding region of the target mRNA. When practicing the present invention, the anti-sense oligonucleotides administered may be related in origin to the species to which it is administered. When treating humans, human anti-sense may be used if desired. Anti-sense oligos to endogenous sequences from other species, however, are also encompassed.

Pharmaceutical compositions comprising an anti-sense oligonucleotide as given above effective to reduce expression of an Ai or A 3 adenosine receptor by passing through a cell membrane and binding specifically with mRNA encoding an Ai or A 3 adenosine receptor in the cell so as to prevent its translation are another aspect of the present invention. Such compositions are provided in a suitable pharmaceutically acceptable carrier, e.g., sterile pyrogen-free saline solution. The anti-sense oligonucleotides may be formulated with a hydrophobic carrier capable of passing through a cell membrane, e.g., in a liposome, with the liposomes carried in a pharmaceutically acceptable aqueous carrier. The oligonucleotides may also be coupled to a substance which inactivates mRNA, such as a ribozyme. Such oligonucleotides may be administered to a subject to inhibit the activation of a target, such as the adenosine receptors, which subject is in need of such treatment for any of the reasons discussed herein. Furthermore, the pharmaceutical formulation may also contain chimeric molecules comprising anti-sense oligonucleotides attached to molecules which are known to be internalized by cells.

314 These oligonucleotide conjugates utilize cellular uptake pathways to increase cellular concentrations of oligonucleotides. Examples of macromolecules used in this manner include transferrin, asialoglycoprotein (bound to oligonucleotides via polylysine) and streptavidin. In the pharmaceutical formulation, the anti-sense compound may be contained within a lipid particle or vesicle, such as a liposome or microcrystal. The particles may be of any suitable structure, such as unilamellar or plurilamellar, so long as the anti-sense oligonucleotide is contained therein. Positively charged lipids such as N- 3 -dioleoyloxi) propyl] N, Ntrimethylammoniumethylsulfate, or "DOTAP," are particularly preferred for such particles and vesicles.

The preparation of such lipid particles is well known.

See, U.S. Patent Nos. 4,880,635 to Janoff et al.; 4,906,477 to Kurono et al.; 4,911,928 to Wallach; 4,917,951 to Wallach; 4,920,016 to Allen et al.; 4,921,757 to Wheatley et al.; etc.

Subjects may be administered the active composition by any means which transports the anti-sense nucleotide composition to the lung. The anti-sense compounds are particularly disclosed herein may be administered to the lungs of a patient by any suitable means, but are preferably administered by generating an aerosol comprised of respirable particles, the respirable particles comprised of the anti-sense compound, which particles the subject inhales. The respirable particles may be liquid or solid. The particles may optionally contain other therapeutic ingredients. Particles comprised of anti-sense compound for practicing the present invention should include particles of respirable size: that is, particles of a size sufficiently small to pass through the mouth and larynx upon inhalation and into the bronchi and alveoli of the lungs. In general, particles ranging from about .5 to about 10 microns in size are respirable. Particles of non-respirable size which are included in the aerosol tend to deposit in the throat and be swallowed, and the quantity of nonrespirable particles in the aerosol is preferably minimized. For nasal administration, a particle size in the range of 10-500 :m is preferred to ensure retention in the nasal cavity. Thus, particles of about 4, about 315 about 25, about 50 to about 75, about 100, about 250, about 500, and other specific ranges therewithin, are preferred. Others, however, are also contemplated within the confines of this invention.

Liquid pharmaceutical compositions of active compound for producing an aerosol can be prepared by combining the anti-sense compound with a suitable vehicle, such as sterile pyrogen free water. Other therapeutic compounds may optionally be included. Solid particulate compositions containing respirable dry particles of micronized anti-sense compound may be prepared by grinding dry anti-sense compound with a mortar and pestle, and then passing the micronized composition through a 400 mesh screen to break up or separate out large agglomerates. A solid particulate composition comprised of the anti-sense compound may optionally contain a dispersant which serves to facilitate the formation of an aerosol. A suitable dispersant is lactose, which may be blended with the anti-sense compound in any suitable ratio a 1 to 1 ratio by weight). Again, other therapeutic compounds may also be included.

The dosage of the anti-sense compound administered will depend upon the disease being treated, the condition of the subject, the particular formulation, the route of administration, the timing of administration to a subject, etc. In general, intracellular concentrations of the oligonucleotide of from about 0.01, about 0.05, about 0.1, about 0.2, about 1 to about 5 2M, about 50 QM, about 100 PM or more, and more particularly about 0.2 to about 0.5 2M, are desired. For administration to a subject such as a human, a dosage of from about 0.01, about 0.1 or about 1 mg/Kg up to about 50, about 100, or about 150 mg/Kg and even higher doses are typically employed depending on the route of administration as is known in the art. Depending on the solubility of the particular formulation of active compound administered, the daily dose may be divided among one or several unit dose administrations. Administration of the anti-sense compounds may be carried out therapeutically as a rescue treatment) or prophylactically. Aerosols of liquid particles comprising the anti-sense compound may be produced by any suitable means, such as with a 316 nebulizer. See, U.S. Patent No. 4,501,729.

Nebulizers are commercially available devices which transform solutions or suspensions of the active ingredient into a therapeutic aerosol mist either by means of acceleration of a compressed gas, typically air or oxygen, through a narrow venturi orifice or by means of ultrasonic agitation. Suitable formulations for use in nebulizers consist of the active ingredient in a liquid carrier, the active ingredient comprising up to 40% w/w of the formulation, but preferably less than 20% w/w. The carrier is typically water or a dilute aqueous alcoholic solution, preferably made isotonic with body fluids by the addition of, for example, sodium chloride. Optional additives include preservatives if the formulation is not prepared sterile, for example, methyl hydroxybenzoate, antioxidants, flavoring agents, volatile oils, buffering agents and surfactants.

In one preferred embodiment, the pharmaceutical composition comprises nucleic acid(s) which comprise the anti-sense oligo(s) described above and one or more surfactants. Suitable surfactants or surfactant components for enhancing the uptake of the anti-sense oligonucleotides of the invention include synthetic and natural as well as full and truncated forms of surfactant protein A, surfactant protein B, surfactant protein C, surfactant protein D and surfactant Protein E, disaturated phosphatidylcholine (other than dipalmitoyl), dipalmitoylphosphatidylcholine, phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, phosphatidylserine; phosphatidic acid, ubiquinones, lysophosphatidylethanolamine, lysophosphatidylcholine, palmitoyl-lysophosphatidylcholine, dehydroepiandrosterone, dolichols, sulfatidic acid, glycerol-3-phosphate, dihydroxyacetone phosphate, glycerol, glycero-3-phosphocholine, dihydroxyacetone, palmitate, cytidine diphosphate (CDP) diacylglycerol, CDP choline, choline, choline phosphate; as well as natural and artificial lamellar bodies which are the natural carrier vehicles for the components of surfactant, omega- 3 fatty acids, polyenic acid, polyenoic acid, lecithin, palmitinic acid, non-ionic block copolymers of ethylene or propylene oxides, polyoxypropylene, monomeric and 317 polymeric, polyoxyethylene, monomeric and polymeric, poly (vinyl amine) with dextran and/or alkanoyl side chains, Brij 35, Triton X-100 and synthetic surfactants ALEC, Exosurf, Survan and Atovaquone, among others. These surfactants may be used either as a single, or as part of a multiple component, surfactant in a formulation, or as covalently bound additions to the 5' and/or 3' ends of the anti-sense oligo(s) Aerosols of solid particles comprising the active compound may likewise be produced with any solid particulate medicament aerosol generator.

Aerosol generators for administering solid particulate medicaments to a subject produce particles which are respirable, as explained above, and generate a volume of aerosol containing a predetermined metered dose of a medicament at a rate suitable for human administration.

One illustrative type of solid particulate aerosol generator is an insufflator. Suitable formulations for administration by insufflation include finely comminuted powders which may be delivered by means of an insufflator or taken into the nasal cavity in the manner of a snuff.

In the insufflator, the powder a metered dose thereof effective to carry out the treatments described herein) is contained in capsules or cartridges, typically made of gelatin or plastic, which are either pierced or opened in situ and the powder delivered by air drawn through the device upon inhalation or by means of a manually-operated pump. The powder employed in the insufflator consists either solely of the active ingredient or of a powder blend comprising the active ingredient, a suitable powder diluent, such as lactose, and an optional surfactant. The active ingredient typically comprises from 0.1 to 100 w/w of the formulation. A second type of illustrative aerosol generator comprises a metered dose inhaler. Metered dose inhalers are pressurized aerosol dispensers, typically containing a suspension or solution formulation of the active ingredient in a liquefied propellant. During use these devices discharge the formulation through a valve adapted to deliver a metered volume, typically from 10 to 150 to produce a fine particle spray containing the active ingredient. Suitable propellants include certain chlorofluorocarbon compounds, for example, dichlorodifluoromethane, trichlorofluoromethane, 318 dichlorotetrafluoroethane and mixtures thereof. The formulation may additionally contain one or more cosolvents, for example, ethanol, surfactants, such as oleic acid or sorbitan trioleate, antioxidants and suitable flavoring agents. The aerosol, whether formed from solid or liquid particles, may be produced by the aerosol generator for example at a rate of from about about 30, about 70 to about 100, about 150, about 150 liters per minute, more preferably from about 30 to 150 liters per minute, and most preferably about 60 liters per minute. Aerosols containing greater amounts of medicament, however, may be administered more rapidly as is known in the art.

The relevant disclosures of all scientific publications and patent references cited in this patent are specifically intended to be incorporated herein by reference, particularly in reference to preparatory methods and technologies which are enabling of the invention. The following examples are provided to illustrate the present invention, and should not be construed as limiting thereon.

EXAMPLES

In the following examples, :M means micromolar, ml means milliliters, :m means micrometers, mm means millimeters, cm means centimeters, EC means degrees Celsius, :g means micrograms, mg means milligrams, g means grams, kg means kilograms, M means molar, and h or hr. means hours.

Example i: Design and Synthesis of Anti-sense Oligonucleotides The design of anti-sense oligonucleotides against the A, and A 3 adenosine receptors may require the solution of the complex secondary structure of the target A, receptor mRNA and the target A 3 receptor mRNA. After generating this structure, anti-sense nucleotide are designed which target regions of mRNA which might be construed to confer functional activity or stability to the mRNA and which optimally may overlap the initiation codon. Other target sites are readily usable. As a demonstration of specificity of the anti-sense effect, other oligonucleotides not totally complementary to the target mRNA, but containing identical nucleotide 319 compositions on a w/w basis, are included as controls in anti-sense experiments.

The mRNA secondary structure of the adenosine Ai receptor was analyzed and used as described above. to design a phosphorothioate anti-sense oligonucleotide. The anti-sense oligonucleotide which was synthesized was designated HAdAiAS and had the following sequence: 5' GAT GGA GGG CGG CAT GGC GGG-3' SEQ ID NO:1). As a control, a mismatched phosphorothioate anti-sense nucleotide designated HAdAlMM1 was synthesized with the following sequence: 5' -GTA GCA GGC GGG GAT GGG GGC-3' (SEQ ID NO:2). Each oligonucleotide had identical base content and general sequence structure. Homology searches in GENBANK (release 85.0) and EMBL (release 40.0) indicated that the anti-sense oligonucleotide was specific for the human and rabbit adenosine Ai receptor genes, and that the mismatched control was not a candidate for hybridization with any known gene sequence.

The secondary structure of the adenosine A 3 receptor mRNA was similarly analyzed and used as described above to design two phosphorothioate anti-sense oligonucleotides. The first anti-sense oligonucleotide (HAdA3AS1) synthesized had the following sequence: 5' GTT GTT GGG CAT CTT GCC-3' (SEQ ID NO:3). As a control, a mismatched phosphorothioate anti-sense oligonucleotide (HAdA3MM1) was synthesized, having the following sequence: 5' -GTA CTT GCG GAT CTA GGC-3' (SEQ ID NO:4).

A second phosphorothioate anti-sense oligonucleotide (HAdA3AS2) was also designed and synthesized, having the following sequence: 5' -GTG GGC CTA GCT CTC GCC-3' (SEQ ID NO:5). Its control oligonucleotide (HAdA3MM2) had the sequence: 5' -GTC GGG GTA CCT GTC GGC-3' (SEQ ID NO:6).

Phosphorothioate oligonucleotides were synthesized on an Applied Biosystems Model 396 Oligonucleotide Synthesizer, and purified using NENSORB chromatography (DuPont, MD).

Example 2: In Vivo Testing of Adenosine Ai Receptor Anti-sense Oligos The anti-sense oligonucleotide against the human Ai receptor (SEQ ID NO:1) described above, was tested for efficacy in an in vitro model utilizing lung adenocarcinoma cells HTB-54. HTB-54 lung adenocarcinoma cells were demonstrated to express the A adenosine receptor using standard northern blotting procedures and 320 receptor probes designed and synthesized in the laboratory.

HTB-54 human lung adenocarcinoma cells (106/100 mm tissue culture dish) were exposed to 5.0 :M HAdAlAS or HAdAlMM1 for 24 hours, with a fresh change of media and oligonucleotides after 12 hours of incubation. Following 24 hour exposure to the oligonucleotides, cells were harvested and their RNA extracted by standard procedures.

A 21-mer probe corresponding to the region of mRNA targeted by the anti-sense (and therefore having the same sequence as the anti-sense, but not phosphorothioated) was synthesized and used to probe northern blots of RNA prepared from HAdAlAS-treated, HAdAlMM1-treated and nontreated HTB-54 cells. These blots showed clearly that HAdAlAS but not HAdAlMM1 effectively reduced human adenosine receptor mRNA by This result showed that HAdAlAS is a good candidate for an anti-asthma drug since it depletes intracellular mRNA for the adenosine Ai receptor, which is involved in asthma.

Example 3: In Vivo Efficacy of Adenosine Ai Receptor Anti-sense Oligos A fortuitous homology between the rabbit and human DNA sequences within the adenosine Ai gene overlapping the initiation codon permitted the use of the phosphorothioate anti-sense oligonucleotides initially designed for use against the human adenosine Ai receptor in a rabbit model. Neonatal New Zealand white Pasteurella-free rabbits were immunized intraperitoneally within 24 hours of birth with 312 antigen units/ml house dustmite farinae) extract (Berkeley Biologicals, Berkeley, CA), mixed with 10% kaolin. Immunizations were repeated weekly for the first month and then biweekly for the next 2 months. At 3-4 months of age, eight sensitized rabbits were anesthetized and relaxed with a mixture of ketamine hydrochloride (44 mg/kg) and acepromazine maleate (0.4 mg/kg) administered intramuscularly. The rabbits were then laid supine in a comfortable position on a small molded, padded animal board and intubated with a 4.0-mm intratracheal tube (Mallinkrodt, Inc., Glens Falls, NY). A polyethylene catheter of external diameter 2.4 mm with an attached latex balloon was passed into the esophagus and maintained at the same distance (approximately 16 cm) from the mouth throughout the 321 experiments. The intratracheal tube was attached to a heated Fleisch pneumotachograph (size 00; DOM Medical, Richmond, VA), and flow was measured using a Validyne differential pressure transducer (Model DP-45161927; Validyne Engineering Corp., Northridge, CA) driven by a Gould carrier amplifier (Model 11-4113; Gould Electronic, Cleveland, OH). The esophageal balloon was attached to one side of the differential pressure transducer, and the outflow of the intratracheal tube was connected to the opposite side of the pressure transducer to allow recording of transpulmonary pressure. Flow was integrated to give a continuous tidal volume, and measurements of total lung resistance (RL) and dynamic compliance (Cdyn) were calculated at isovolumetric and flow zero points, respectively, using an automated respiratory analyzer (Model 6; Buxco, Sharon, CT) Animals were randomized and on Day 1 pretreatment values for PC50 were obtained for aerosolized adenosine. Anti-sense (HAdAlAS) or mismatched control (HAdAlMM) oligonucleotides were dissolved in sterile physiological saline at a concentration of 5000 :g (5 mg) per 1.0 ml. Animals were subsequently administered the aerosolized anti-sense or mismatch oligonucleotide via the intratracheal tube (approximately 5000 :g in a volume of 1.0 ml), twice daily for two days. Aerosols of either saline, adenosine, or anti-sense or mismatch oligonucleotides were generated by an ultrasonic nebulizer (DeVilbiss, Somerset, PA), producing aerosol droplets 80% of which were smaller than :m in diameter. In the first arm of the experiment, four randomly selected allergic rabbits were administered anti-sense oligonucleotide and four the mismatched control oligonucleotide. On the morning of the third day, values (the concentration of aerosolized adenosine in mg/ml required to reduce the dynamic compliance of the bronchial airway 50% from the baseline value) were obtained and compared to PC50 values obtained for these animals prior to exposure to oligonucleotide. Following a 1 week interval, animals were crossed over, with those previously administered mismatch control oligonucleotide now administered anti-sense oligonucleotide, and those previously treated with anti-sense oligonucleotide now administered mismatch control oligonucleotide. Treatment methods and measurements were identical to those employed 322 in the first arm of the experiment. It should be noted that in six of the eight animals treated with anti-sense oligonucleotide, adenosine-mediated bronchoconstriction could not be obtained up to the limit of solubility of adenosine, 20 mg/ml. For the purpose of calculation, values for these animals were set at 20 mg/ml. The values given therefore represent a minimum figure for anti-sense effectiveness. Actual effectiveness was higher. The results of this experiment are illustrated in Table below.

Table 5: Effect of Adenosine Ai Receptor Anti-sense Oligo upon PC50 Values in Asthmatic Rabbits Mismatch Control Ai Receptor Antisense Oligo Pre Post Pre Post Oligonucleoti Oligonucleoti Oligonucleotid Oligonucleotid de de e e 3.56 1.02 5.16 1.03 2.36 0.68 >19.5 0.34** The results are presented as the mean SEM.

The significance was determined by repeated-measures analysis of variance (ANOVA), and Tukeys protected test.

"Significantly different from all other groups. p<0.01.

In both arms of the experiment, animals receiving the anti-sense oligonucleotide showed an order of magnitude increase in the dose of aerosolized adenosine required to reduce dynamic compliance of the lung by No effect of the mismatched control oligonucleotide upon PC50 values was observed. No toxicity was observed in any animal receiving either anti-sense or control inhaled oligonucleotide. These results show clearly that the lung has exceptional potential as a target for anti-sense oligonucleotide-based therapeutic intervention in lung disease. They further show, in a model system which closely resembles human asthma, that downregulation of the adenosine Ai receptor largely eliminates adenosinemediated bronchoconstriction in asthmatic airways.

Bronchial hyperresponsiveness in the allergic rabbit model of human asthma is an excellent endpoint for antisense intervention since the tissues involved in this response lie near to the point of contact with aerosolized oligonucleotides, and the model closely simulates an important human disease.

323 Example 4: Specificity of A 1 -adenosine Receptor Antisense Oligonucleotide At the conclusion of the cross-over experiment of Example 3 above, airway smooth muscle from all rabbits was quantitatively analyzed for adenosine Ai receptor number. As a control for the specificity of the antisense oligonucleotide, adenosine A 2 receptors, which should not have been affected, were also quantified.

Airway smooth muscle tissue was dissected from each rabbit and a membrane fraction prepared according to the method of Kleinstein et al. (Kleinstein, J. and Glossmann, Naunyn-Schmiedeberg's Arch. Pharmacol.

305: 191-200 (1978)), the relevant portion of which is hereby incorporated in its entirety by reference, with slight modifications. Crude plasma membrane preparations were stored at 70EC until the time of assay. Protein content was determined by the method of Bradford (M.

Bradford, Anal. Biochem. 72, 240-254 (1976), the relevant portion of which is hereby incorporated in its entirety by reference). Frozen plasma membranes were thawed at room temperature and were incubated with 0.2 U/ml adenosine deaminase for 30 minutes at 37EC to remove endogenous adenosine. The binding of 3 H] DPCPX (A 1 receptor-specific) or [3H] CGS-21680 (A 1 receptorspecific) was measured as previously described by Ali et al. (Ali, S. et al., J. Pharmacol. Exp. Ther. 268, Am. J.

Physiol 266, L271-277 (1994), the relevant portion of which is hereby incorporated in its entirety by reference). The animals treated with adenosine Ai antisense oligonucleotide in the cross-over experiment had a nearly 75% decrease in Ai receptor number compared to controls, as assayed by specific binding of the Alspecific antagonist DPCPX. There was no change in adenosine A 2 receptor number, as assayed by specific binding of the A 2 receptor-specific agonist 2- (2carboxyethyl)-phenethylamino] (N-ethylcarboxamido) adenosine (CGS-21680). This is illustrated in Table 6 below.

Table 6: Specificity of Action of Adenosine Ai Receptor Oligonucleotide Anti-sense Mismatch Control Ai Antisense Oligonucleotide Oligonucleotide Al-Specific 1105 48** 293 18 Binding

A

2 -Specific 302 22 442 171 324 Binding The results are presented as the mean (n 8) SEM.

The significance was determined by repeated-measures analysis of variance (ANOVA), and Tukey's protected test.

"Significantly different from mismatch control, p<0.01.

The above results illustrate the effectiveness of anti-sense oligonucleotides in treating airway disease.

Since the anti-sense oligos described above, eliminate the receptor systems responsible for adenosine-mediated bronchoconstriction, it may be less imperative to eliminate adenosine from them. However, it would be preferable to eliminate adenosine from even these oligonucleotides to reduce the dose needed to attain a similar effect. Described above are other anti-sense oligonucleotides targeting mRNA of proteins involved in inflammation. Adenosine has been eliminated from their nucleotide content to prevent its liberation during degradation.

Example 5: Anti-sense Oligos directed to other Target Nucleic Acids This work was conducted to demonstrate that the present invention is broadly applicable to anti-sense oligonucleotides ("oligos") specific to nucleic acid targets broadly. The following experimental studies were conducted to show that the method of the invention is broadly suitable for use with anti-sense oligos designed as taught by this application and targeted to any and all adenosine receptor mRNAs. For this purpose, various antisense oligos were porepared to adenosine receptor mRNAs exemplified by the adenosine A2b and A 3 receptor mRNAs.

Anti-sense Oligo I was disclosed above (SEQ. ID NO:1).Five additional anti-sense phosphorothioate oligos were designed asnd synthesized as indicated above.

1- Oligo II (SEQ. ID NO: 7) also targeted to the adenosine Ai receptor, but to a different region than Oligo I.

2- Oligo V (SEQ. ID NO: 10) targeted to the adenosine A2b receptor.

3- Oligos III (SEQ. ID NO: 8) and IV (SEQ. ID NO: 9) targeted to different regions of the adenosine A 3 receptor.

4- Oligo I-PD (SEQ. ID NO: 1681)(a phosphodiester oligo of the same sequence as Oligo I).

These anti-sense oligos were designed for therapy on a selected species as described above and are generally specific for that species, unless the segment of the target mRNA of other species happens to contain a similar sequences. All anti-sense oligos were prepared as described below, and tested in vivo in a rabbit model for bronchoconstriction, inflammation and allergy, which have 325 breathing difficulties and impeded lung airways, as is the case in ailments such as asthma, as described in the above-identified application.

Example 6: Design Sequences of other Anti-sense Oligos Six oligos and their effects in a rabbit model were studied and the results of these studies are reported and discussed below. Five of these oligos were selected for this study to complement the data on Oligo I (SEQ ID NO: 1) provided in Examples 1 to 4 above. This oligo is antisense to one region of the adenosine Ai receptor mRNA.

The oligos tested are identified as anti-sense Oligos I (SEQ ID NO: 1) and II (SEQ. ID No: 7) targeted to a different region of the adenosine Ai receptor mRNA, Oligo V (SEQ. ID No:8) targeted to the adenosine A2b receptor mRNA, and anti-sense Oligos III and IV (SEQ. ID NOS: 9 and 10) targeted to two different regions of the adenosine A 3 receptor mRNA. The sixth oligo (Oligo I-PD) is a phosphodiester version of Oligo I (SEQ. ID NO:1).

The design and synthesis of these anti-sense oligos was performed in accordance with Example 1 above.

Anti-sense Oligo I The anti-sense oligonucleotide I referred to in Examples 1 to 4 above is targeted to the human Ai adenosine receptor mRNA (EPI 2010). Anti-sense oligo I is 21 nucleotide long, overlaps the initiation codon, and has the following sequence:5'-GAT GGA GGG CGG CAT GGC GGG-3'(SEQ.ID NO:1). The oligo I was previously shown to abrogate the adenosine-induced bronchoconstriction in allergic rabbits, and to reduce allergen-induced airway obstruction and bronchial hyperresponsiveness (BHR), as discussed above and shown by Nyce, J. W. Metzger, W.

Nature, 385:721 (1977), the relevant portions of which reference are incorporated in their entireties herein by reference.

(II) Anti-sense Oligo II A phosphorothioate anti-sense oligo (SEQ. ID NO:7) was designed in accordance with the invention to target the rabbit adenosine A, receptor mRNA region +936 to +956 relative to the initiation codon (start site). The antisense oligo II is 21 nucleotide long, and has the following sequence: 5'-CTC GTC GCC GTC GCC GGC GGG-3' (SEQ. ID NO:7).

326 (III) Anti-sense Oligo III A phosphorothioate anti-sense oligo other than that provided in Example 1 above (SEQ. ID NO:8) was designed in accordance with the invention to target the anti-sense

A

3 receptor mRNA region +3 to 22 relative to the initiation codon start site. The anti-sense oligo III is nucleotide long, and has the following sequence: GGG TGG TGC TAT TGT CGG GC-3' (SEQ. ID NO:8).

(IV) Anti-sense Oligo IV Yet another phosphorothioate anti-sense oligo (SEQ.

ID NO:9) was designed in accordance with the invention to target the adenosine A 3 receptor mRNA region 386 to 401 relative to the initiation codon (start site). The anti-sense oligo IV is 15 nucleotide long, and has the following sequence: 5'-GGC CCA GGG CCA GCC-3' (SEQ. ID NO:9) Anti-sense Oligo V A phosphorothioate anti-sense oligo (SEQ. ID was designed in accordance with the invention to target the adenosine A2b receptor mRNA region -21 to -1 relative to the initiation codon (start site). The anti-sense oligonucleotide V is 21 nucleotide long, and has the following sequence: 5'-GGC CGG GCC AGC CGG GCC CGG-3' (SEQ. ID (VI) Ai Mismatch Oligos Two different mismatched oligonucleotides having the following sequences were used as controls for anti-sense oligo I(SEQ. ID NO: 1) described in Example 5 above: Ai GGT GGC GGG CAA GGC GGG-3' (SEQ. ID NO:2421), and Ai MM3:5'-GAT GGA GGC GGG CAT GGC GGG-3, (SEQ. ID NO:2422). Anti-sense oligo I and the two mismatch antisense oligos had identical base content and general sequence structure. Homology searches in GENBANK (release 85.0) and EMBL (release 40.0) indicated that the antisense oligo I was specific, not only for the human, but also for the rabbit, adenosine Ai receptor genes, and that the mismatched controls were not candidates for hybridization with any known human or animal gene sequence.

(VII) Anti-sense Oligo Ai-PD (Oligo VI) A phosphodiester anti-sense oligo (Oligo VI; SEQ. ID NO:2420) having the same nucleotide sequence as Oligo I was designed as disclosed in the above-identified 327 application. Anti-sense oligo I-PD is 21 nucleotide long, overlaps the initiation codon, and has the following sequence: GAT GGA GGG CGG CAT GGC GGG-3' (SEQ. ID NO:2420).

III) Controls Each rabbit was administered 5.0 ml aerosolized sterile saline following the same schedule as for the anti-sense oligos in (III), and (IV) above.

Example 7: Synthesis of Anti-sense Oligos Phosphorothioate anti-sense oligos having the sequences described in above, were synthesized on an Applied Biosystems Model 396 Oligonucleotide Synthesizer, and purified using NENSORB chromatography (DuPont, DE).

TETD (tetraethylthiuram disulfide) was used as the sulfurizing agent during the synthesis. Anti-sense oligonucleotide II (SEQ. ID NO:7), anti-sense oligonucleotide III (SEQ. ID NO: 8) and anti-sense oligonucleotide IV (SEQ. ID NO: 9) were each synthesized and purified in this manner.

Example 8: Preparation of Allergic Rabbits Neonatal New Zealand white Pasturella-free rabbits were immunized intraperitoneally within 24 hours of birth with 0.5 ml of 312 antigen units/ml house dust mite (D.

farinae) extract (Berkeley Biologicals, Berkeley, CA) mixed with 10% kaolin as previously described (Metzger, W. in Late Phase Allergic Reactions, Dorsch, Ed., CRC Handbook, pp. 347-362, CRC Press, Boca Raton (1990); Ali, Metzger, W. J. and Mustafa, S. Am. J. Resp.

Crit. Care Med. 149: 908 (1994)), the relevant portions of which are incorporated in their entireties here by reference. Immunizations were repeated weekly for the first month and then biweekly until the age of 4 months.

These rabbits preferentially produce allergen-specific IgE antibody, typically respond to aeroallergen challenge with both an early and late-phase asthmatic response, and show bronchial hyper responsiveness (BHR). Monthly intraperitoneal administration of allergen (312 units dust mite allergen, as above) continues to stimulate and maintain allergen-specific IgE antibody and BHR. At 4 months of age, sensitized rabbits were prepared for aerosol administration as described by Ali et al. (Ali, Metzger, W. J. and Mustafa, S. Am. J. Resp. Crit.

Care Med. 149 (1994)), the relevant section being 328 incorporated in its entirety here by reference.

DOSE-RESPONSE STUDIES Example 9: Experimental Setup Aerosols of either adenosine (0-20 mg/ml), or antisense or one of two mismatch oligonucleotides (5 mg/ml) were separately prepared with an ultrasonic nebulizer (Model 646, DeVilbiss, Somerset, PA), which produced aerosol droplets, 80% of which were smaller than 5:m in diameter. Equal volumes of the aerosols were administered directly to the lungs via an intratracheal tube. The animals were randomized, and administered aerosolized adenosine. Day 1 pre-treatment values for sensitivity to adenosine were calculated as the dose of adenosine causing a 50% loss of compliance (PCso Adenosine). The animals were then administered either the aerosolized anti-sense or one of the mismatch anti-sense oligos via the intratracheal tube (5 mg/l.0 ml), for 2 minutes, twice daily for 2 days (total dose, 20 mg). Posttreatment PCso values were recorded (post-treatment challenge) on the morning of the third day. The results of these studies are provided in Example 21 below.

Example 10: Crossover Experiments For some experiments utilizing anti-sense oligo I (SEQ ID NO: 1) and a corresponding mismatch control oligonucleotide A1MM2, following a 2 week interval, the animals were crossed over, with those previously administered the mismatch control AIMM2, now receiving the anti-sense oligo I, and those previously treated with the anti-sense oligo I, now receiving the mismatch control AIMM2 oligo. The number of animals per group was as follows. For mismatch AiMM2 (Control n=7, since one animal was lost in the second control arm of the experiment due to technical difficulties, for mismatch AIMM3 n=4 (Control 2) and for AIAS anti-sense oligo I, n=8. The AIMM3 oligo-treated animals were analyzed separately and were not part of the cross-over experiment. The treatment methods and measurements employed following the cross-over were identical to those employed in the first arm of the experiment. In 6 of the 8 animals treated with the anti-sense oligo I (SEQ. ID NO: no PC 50 value could be obtained for adenosine doses of up to 20 mg/ml, which is the limit of solubility 329 of adenosine. Accordingly, the PCso values for these animals were assumed to be 20 mg/ml for calculation purposes. The values given, therefore, represent a minimum figure for the effectiveness of the anti-sense oligonucleotides of the invention. Other groups of allergic rabbits (n=4 for each group) were administered or 0.05 mg doses of the anti-sense oligo I (SEQ ID NO: or the AIMM2 oligo in the manner and according to the schedule described above (the total doses being or 0.2 mg). The results of these studies are provided in Example 22 below.

Example 11: Anti-sense Oligo Formulation Each one of anti-sense oligos were separately solubilized in an aqueous solution and administered as described for anti-sense oligo I (SEQ. ID No:l) in (e) above, in four 5 mg aliquots (20 mg total dose) by means of a nebulizer via endotracheal tube, as described above.

The results obtained for anti-sense oligo I and its mismatch controls confirmed that the mismatch controls are equivalent to saline, as described in Example 19 below and in Table 1 of Nyce Metzger, Nature 385: 721- 725 (1997). Because of this finding, saline was used as a control for pulmonary function studies employing antisense oligos II, III and IV (SEQ. IS NOS; 7, 8 and 9).

Example 12: Specificity of Oligo I for Adenosine Ai Receptor (Receptor Binding Studies) Tissue from airway smooth muscle was dissected to primary, secondary and tertiary bronchi from rabbits which had been administered 20 mg oligo I (SEQ ID NO: 1) in 4 divided doses over a period of 48 hours as described above. A membrane fraction was prepared according to the method of Ali et al. (Ali, et al., Am. J. Resp. Crit.

Care Med. 149: 908 (1994), the relevant section relating to the preparation of the membrane fraction is incorporated in its entirety hereby by reference). The protein content was determined by the method of Bradford and plasma membranes were incubated with 0.2 U/ml adenosine deaminase for 30 minutes at 37EC to remove endogenous adenosine. See, Bradford, M. M. Anal.

Biochem. 72, 240-254 (1976), the relevant portion of which is hereby incorporated in its entirety by reference. The binding of 3 H]DPCPX, 3 H]NPC17731, or 3 H]CGS-21680 was measured as described by Jarvis et al.

330 See, Jarvis, et al., Pharmacol. Exptl. Ther. 251, 888-893 (1989), the relevant portion of which is fully incorporated herein by reference. The results of this study are shown in Table 8 and discussed in Example below.

Example 13: Pulmonary Function Measurements (Compliance CDN and Resistance) At 4 months of age, the immunized animals were anesthetized and relaxed with 1.5 ml of a mixture of ketamine HC1 (35 mg/kg) and acepromazine maleate mg/kg) administered intramuscularly. After induction of anesthesia, allergic rabbits were comfortably positioned supine on a soft molded animal board. Salve was applied to the eyes to prevent drying, and they were closed. The animals were then intubated with a 4.0 mm intermediate high-low cuffed Murphy 1 endotracheal tube (Mallinckrodt, Glen Falls, NY), as previously described by Zavala and Rhodes. See, Zavala and Rhodes, Proc. Soc. Exp. Biol.

Med. 144: 509-512 (1973), the relevant portion of which is incorporated herein by reference in its entirety. A polyethylene catheter of OD 2.4 mm (Becton Dickinson, Clay Adams, Parsippany NJ) with an attached thin-walled latex balloon was passed into the esophagus and maintained at the same distance (approximately 16 cm) from the mouth throughout the experiment. The endotracheal tube was attached to a heated Fleisch pneumotach (size 00; DEM Medical, Richmond, VA), and the flow measured using a Validyne differential pressure transducer (Model DP-45-16-1927, Validyne Engineering, Northridge, CA), driven by a Gould carrier amplifier (Model 11-4113, Gould Electronics, Cleveland, OH). An esophageal balloon was attached to one side of the Validyne differential pressure transducer, and the other side was attached to the outflow of the endotracheal tube to obtain transpulmonary pressure (Ptp) The flow was integrated to yield a continuous tidal volume, and the measurements of total lung resistance (Re) and dynamic compliance (Cdn) were made at isovolumetric and zero flow points. The flow, volume and pressure were recorded on an eight channel Gould 2000 W high-frequency recorder and Cdn was calculated using the total volume and the difference in Ptp at zero flow, and Rt was calculated as the ratio of Ptp and V at midtidal lung volumes.

331 These calculations were made automatically with the Buxco automated pulmonary mechanics respiratory analyzer (Model 6, Buxco Electronics, Sharon, CT), as previously described by Giles et al. See, Giles et al., Arch. Int.

Pharmacodyn. Ther. 194: 213-232 (1971), the relevant portion of which describing these calculations is incorporated in toto hereby by reference. The results obtained upon administration of oligo II on allergic rabbits are shown and discussed in Example 26 below.

Example 14: Measurement of Bronchial Hyperresponsiveness (BHR) Each allergic rabbit was administered histamine by aerosol to determine their baseline hyperresponsiveness.

Aerosols of either saline or histamine were generated using a DeVilbiss nebulizer (DeVilbiss, Somerset, PA) for seconds and then for 2 minutes at each dose employed.

The ultrasonic nebulizer produced aerosol droplets of which 80% were <5 micron in diameter. The histamine aerosol was administered in increasing concentrations (0.156 to 80 mg/ml) and measurements of pulmonary function were made after each dose. The B4R was then determined by calculating the concentration of histamine (mg/ml) required to reduce the Cdy 50% from baseline Histamine) Example 15: Cardiovascular Effect of Anti-sense Oligo

I

The measurement of cardiac output and other cardiovascular parameters using CardiomaxJ utilizes the principal of thermal dilution in which the change in temperature of the blood exiting the heart after a venous injection of a known volume of cool saline is monitored.

A single rapid injection of cool saline was made into the right atrium via cannulation of the right jugular vein, and the corresponding changes in temperature of the mixed injectate and blood in the aortic arch were recorded via cannulation of the carotid artery by a temperaturesensing miniprobe. Twelve hours after the allergic rabbits had been treated with aerosols of oligo I (EPI 2010; SEQ. ID NO: 1) as described in above, the animals were anesthetized with 0.3 ml/kg of 80% Ketamine and 20% Xylazine. This time point coincides with previous data showing efficacy for SEQ. ID NO: 1, as is clearly shown by Nyce Metzger, (1997), supra, the 332 pertinent disclosure being incorporated in its entirety here by reference. A thermocouple was then inserted into the left carotid artery of each rabbit, and was then advanced 6.5 cm and secured with a silk ligature. The right jugular vein was then cannulated and a length of polyethylene tubing was inserted and secured. A thermodilution curve was then established on a CardiomaxJ II (Columbus Instruments, Ohio) by injecting sterile saline at 20EC to determine the correctness of positioning of the thermocouple probe. After establishing the correctness of the position of the thermocouple, the femoral artery and vein were isolated.

The femoral vein was used as a portal for drug injections, and the femoral artery for blood pressure and heart rate measurements. Once constant baseline cardiovascular parameters were established, CardiomaxJ measurements of blood pressure, heart rate, cardiac output, total peripheral resistance, and cardiac contractility were made.

Example 16: Duration of Action of Oligo I (SEQ. ID NO: 1) Eight allergic rabbits received initially increasing log doses of adenosine by means of a nebulizer via an intra-tracheal tube as described in above, beginning with 0.156 mg/ml until compliance was reduced by 50% Adenosine) to establish a baseline. Six of the rabbits then received four 5 mg aerosolized doses of (SEQ. ID NO: 1) as described above. Two rabbits received equivalent amounts of saline vehicle as controls. Beginning 18 hours after the last treatment, the PC50 Adenosine values were tested again. After this point, the measurements were continued for all animals each day, for up to 10 days.

The results of this study are discussed in Example below.

Example 17: Reduction of Adenosine A2b Receptor Number by Anti-sense Oligo V Sprague Dawley rats were administered 2.0 mg respirable anti-sense oligo V (SEQ ID NO:l0) three times over two days using an inhalation chamber as described above. Twelve hours after the last administration, lung parenchymal tissue was dissected and assayed for adenosine A2b receptor binding using [311] -NECA as described by Nyce Metzger (1997), supra. Controls were 333 conducted by administration of equal volumes of saline.

The results are significant at p<0.05 using Student's paired t test, and are discussed in Example 28 below.

Example 18: Comparison of Oligo I Corresponding Phosphodiester Oligo VI (SEQ. ID NO:1681) Oligo I (SEQ ID NO:1) countered the effects of adenosine and eliminated sensitivity to it for adenosine amounte up to 20 mg adenosine/5.0 ml (the limit of solubility of adenosine). Oligo VI (SEQ ID NO:1681), the phosphodiester version of the oligonucleotide sequence, was completely ineffective when tested in the same manner. Both compounds have identical sequence, differing only in the presence of phosphorothioate residues in Oligo I (SEQ ID NO:1), and were delivered as an aerosol as described above and in Nyce Metzger (1997), supra.

Significantly different at p<0.001, Student's paired t test. The results are discussed in Example 29 below.

RESULTS OBTAINED FOR ANTI-SENSE OLIGO I (SEQ. ID NO: 1) Example 19: Results of Prior Work The nucleotide sequence and other data for antisense oligo I (SEQ. ID NO: which is specific for the adenosine Ai receptor, were provided above. The experimental data showing the effectiveness of oligo I in down regulating the receptor number and activity were also provided above. Further information on the characteristics and activities of anti-sense oligo I is provided in Nyce, J. W. and Metzger, W. Nature 385:721 (1997), the relevant parts of which relating to the following results are incorporated in their entireties herein by reference. The Nyce Metzger (1997) publication provided data showing that the anti-sense oligo I (SEQ. ID NO: 1): The anti-sense oligo I reduces the number of adenosine Ai receptors in the bronchial smooth muscle of allergic rabbits in a dose-dependent manner as may be seen in Table 5 below.

Anti-sense Oligo I attenuates adenosineinduced bronchoconstriction and allergen-induced bronchoconstriction.

The Oligo I attenuates bronchial hyperresponsiveness as measured by PCso histamine, a standard measurement to assess bronchial hyperresponsiveness. This result clearly 334 demonstrates anti-inflammatory activity of the anti-sense oligo I as is shown in Table 5 above.

As expected, because it was designed to target it, the anti-sense oligo I is totally specific for the adenosine Ai receptor, and has no effect at all at any dose on either the very closely related adenosine A 2 receptor or the related bradykinin B 2 receptor. This is seen in Table below.

In contradistinction to the above effects of the Oligo I, the mismatch control molecules MM2 and MM3 (SEQ. ID NO:1682 and SEQ. ID NO:1683) which have identical base composition and molecular weight but differed from the anti-sense oligo I (SEQ ID NO: 1) by 6 and 2 mismatches, respectively.

These mismatches, which are the minimum possible while still retaining identical base composition, produced absolutely no effect upon any of the targeted receptors A 2 or B 2 These results, along with a complete lack of prior art on the use of anti-sense oligonucleotides, such as oligo I, targeted to the adenosine Ai receptor, are unexpected results. The showings presented in this patent clearly enable and demonstrate the effectiveness, for their intended use, of the claimed agents and method for treating a disease or condition associated with lung airway, such as bronchoconstriction, inflammation, allergy(ies), and the like.

Example 20: Oligo I Significantly Reduces Response to Adenosine Challenge The receptor binding experiment is described in Example 12 above, and the results shown in Table 5 below which shows the binding characteristics of the adenosine

A

1 -selective ligand 3 H]DPCPX and the bradykinin B 2 selective ligand 3 H]NPC 17731 in membranes isolated from airway smooth muscle of Ai adenosine receptor and B 2 bradykinin receptor anti-sense- and mismatch-treated allergic rabbits.

Table 5: Binding Characteristics of Three Anti- Sense Oligos Treatment i Ai receptor B 2 receptor Kd Ba Kd Bmax Adenosine Receptor mg 0.36+0.02 19+1.52 0.39±0.031 14.8±0.99 335 2 mg 0.2 mg AxMM 1 mg 2 mg

B

2

A

mg 2 mg 0.2 mg

B

2

MM

mg 2 mg 0.2 mg Saline 0.38+0.03 0.37+0.03 (Control) 0.34+0.02 0.37+0.03 Receptor) 0.36+0.02 0.39+0.035 0.40+0.028 0.39+0.031 0.41+0.035 0.37+0.029 0.37+0.041 32+2.56 49+3.43 52.0+3.64 51.8+3.88 45.0+3.15 44.3±2.90 47.0±3.76 42.0±2.94 40.0±3.20 430±3 .14 46.0±5.21 0.41+0.028 0.34+0.024 0.35+0.024 0.38+0.028 0.38+0.027 0.34±0.024 nM 0.35±0.028 nM 0.41±0.029 nM 0.37±0.030 nM 0.36±0.025 nM 0.39±0.047 nM 15.5+1.08 15.0+1.06 14.0+1.0 14.6+1.02 8.7+0.62 11.9+0.76 15.1±1.05 -I 14 .0±0 .98 14 .80.99 15.1+1.35 14.2+1.35 Refers to total oligo administered in four equivalently divided doses over a 48 hour period. Treatments and analyses were performed as described in methods. Significance was determined by repeated-measures analysis of variance (ANOVA), and Tukey=s protected t test. n 4-6 for all groups.

Significantly different from mismatch control- and saline-treated groups, p<0.001; "Sianificantlv different from mismatch control- and saline-treated arouos. o<0.05.

Example 21: Dose-response Effect of Oligo I Anti-sense oligo I (SEQ ID NO:1) was found to reduce the effect of adenosine administration to the animal in a dose-dependent manner over the dose range tested as shown in Table 6 below.

Table 6: Dose-Response Effect to Anti-sense Oligo I Total Dose (mg) Anti-sense Oligo I 0.2

PC

50 Adenosine (mq Adenosine) 8.32+7.2 14.0+7.2 19.5+0.34

A

1 MM2 oligo (control) 0.2 2.51+0.46 3.13± 0.71 3.25+ 0.34 The above results were studied with the Student's paired t test and found to be statistically different, p=0.05 The oligo I (SEQ. ID NO:1), an anti-adenosine Al receptor oligo, acts specifically on the adenosine A, receptor, but not on the adenosine A 2 receptors. These results stem from the treatment of rabbits with anti- 336 sense oligo I (SEQ. ID NO.1) or mismatch control oligo (SEQ. ID NO:1682; AIMM2) as described in Example 9 above and in Nyce Metzger (1997), supra (four doses of 5 mg spaced 8 to 12 hours apart via nebulizer via endotracheal tube), bronchial smooth muscle tissue excised and the number of adenosine Ai and adenosine A 2 receptors determined as reported in Nyce Metzger (1997), supra.

Example 22: Specificity of Oligo I (SEQ. ID NO:1) for Target Gene Product Oligo I (SEQ. ID No:l) is specific for the adenosine Ai receptor whereas its mismatch controls had no activity.

Figure 1 depicts the results obtained from the cross-over experiment described in Example 10 above and in Nyce Metzger (1997), supra. The two mismatch controls (SEQ.

ID NO:1682 and SEQ. ID NO:1683) evidenced no effect on the PC50 Adenosine value. On the contrary, the administration of anti-sense oligo I (SEQ. ID NO:1) showed a seven-fold increase in the PCso 50 Adenosine value. The results clearly indicate that the anti-sense oligo I (SEQ. ID NO: 1) reduces the response (attenuates the sensitivity) to exogenously administered adenosine when compared with a saline control. The results provided in Table 6 above clearly establish that the effect of the anti-sense oligo I is dose dependent (see, column 3 of Table The Oligo I was also shown to be totally specific for the adenosine Ai receptor, (see, top 3 rows of Table), inducing no activity at either the closely related adenosine A 2 receptor or the bradykinin B 2 receptor (see, lines 8-10 of Table 6 above). In addition, the results shown in Table 6 establish that the anti-sense oligo I (SEQ. ID NO:1) decreases sensitivity to adenosine in a dose dependent manner, and that it does this in an anti-sense oligo-dependent manner since neither of two mismatch control oligonucleotides (AIMM2; SEQ. ID NO:1682 and AIMM3; SEQ. ID NO:1683) show any effect on PC50 Adenosine values or on attenuating the number of adenosine Ai receptors.

Example 23: Effect on Aeroallergen-induced Bronchoconstriction Inflammation The Oligo I (SEQ. ID NO:1) was shown to significantly reduce the histamine-induced effect in the rabbit model when compared to the mismatch oligos. The effect of the anti-sense Oligo I (SEQ. ID No:l) and the 337 mismatch oligos (AiMM2, SEQ. ID NO:1682 and AIMM3, SEQ. ID NO:1682) on allergen-induced airway obstruction and bronchial hyperresponsiveness was assessed in allergic rabbits. The effect of the anti-sense oligo I (SEQ. ID NO:1) on allergen-induced airway obstruction was assessed. As calculated from the area under the plotted curve, the anti-sense oligo I significantly inhibited allergen-induced airway obstruction when compared with the mismatched control p<0.05; repeated measures ANOVA, and Tukey's t test). A complete lack of effect was induced by the mismatch oligo A 1 MM2 (Control) on allergen induced airway obstruction. The effect of the anti-sense oligo I (SEQ. ID NO:1) on allergen-induced BHR was determined as above. As calculated from the PCs 0 Histamine value the anti-sense oligo I (SEQ. ID NO:1) significantly inhibited allergen-induced BHR in allergic rabbits when compared to the mismatched control (61%, p<0.05; repeated measures ANOVA, Tukey's t test). A complete lack of effect of the AIMM mismatch control on allergen-induced BHR was observed. The results indicated that anti-sense oligo I (SEQ. ID NO: 1) is effective to protect against aeroallergen-induced bronchoconstriction (house dust mite). In addition, the anti-sense oligo I (SEQ. ID NO:1) was also found to be a potent inhibitor of dust mite-induced bronchial hyper responsiveness, as shown by its effects upon histamine sensitivity which indicates anti- inflammatory activity for anti-sense oligo I (SEQ. ID NO:1).

Example 24: Anti-sense Oligo I is Free of Deleterious Side Effects The Oligo I (SEQ. ID NO:1) was shown to be free of side effects that might be toxic to the recipient. No changes in arterial blood pressure, cardiac output, stroke volume, heart rate, total peripheral resistance or heart contractility (dPdT) were observed following administration of 2.0 or 20 mg oligo I (SEQ. ID NO:1).

The addition, the results of the measurement of cardiac output stroke volume mean arterial pressure (MAP), heart rate total peripheral resistance (TPR), and contractility (dPdT) with a CardiomaxJ apparatus (Columbus Instruments, Ohio) were assessed.

These results evidenced that oligo I (SEQ. ID NO:1) has no detrimental effect upon critical cardiovascular 338 parameters. More particularly, this oligo does not cause hypotension. This finding is of particular importance because other phosphorothioate anti-sense oligonucleotides have been shown in the past to induce hypotension in some model systems. Furthermore, the adenosine A 1 receptor plays an important role in sinoatrial conduction within the heart. Attenuation of the adenosine Ai receptor by anti-sense oligo I (SEQ. ID NO:1) might be expected to result, therefore, in deleterious extrapulmonary activity in response to the downregulation of the receptor. This is not the case. The anti-sense oligo I (SEQ. ID NO:1) does not produce any deleterious intrapulmonary effects and renders the administration of the low doses of the present anti-sense oligo free of unexpected, undesirable side effects. This demonstrates that when oligo I (SEQ. ID NO:1) is administered directly to the lung, it does not reach the heart in significant quantities to cause deleterious effects. This is in contrast to traditional adenosine receptor antagonists like theophylline which do escape the lung and can cause deleterious, even lifethreatening effects outside the lung.

Example 25: Long Lasting Effect of Oligo I The Oligo I (SEQ. ID NO:1) evidenced a long lasting effect as evidenced by the PCso and Resistance values obtained upon its administration prior to adenosine challenge. The duration of the effect was measured for with respect to the PC 0 s of adenosine anti-sense oligo I when administered in four equal doses of 5 mg each by means of a nebulizer via an endotracheal tube, as described above. The effect of the agent is significant over days 1 to 8 after administration. When the effect of the anti-sense oligo I (SEQ. ID NO:1) had disappeared, the animals were administered saline aerosols (controls), and the PC 50 Adenosine values for all animals were measured again. Saline-treated animals showed base line PC 50 adenosine values The duration of the effect (with respect to Resistance) was measured for six allergic rabbits which were administered 20 mg of anti-sense oligo I (SEQ. ID NO: 1) as described above, upon airway resistance measured as also described above. The mean calculated duration of effect was 8.3 days for both PCso adenosine (p<0.05) and resistance These 339 results show that anti-sense oligo I (SEQ. ID NO:1) has an extremely long duration of action, which is completely unexpected.

Example 26: Anti-sense Oligo II Anti-sense oligo II, targeted to a different region of the adenosine Ai receptor mRNA, was found to be highly active against the adenosine A,-mediated effects. The experiment measured the effect of the administration of anti-sense oligo II (SEQ. ID NO:7) upon compliance and resistance values when 20 mg anti-sense oligo II or saline (control) were administered to two groups of allergic rabbits as described above. Compliance and resistance values were measured following an administration of adenosine or saline as described above in Example 13. The effect of the anti-sense oligo of the invention was different from the control in a statistically significant manner, p<0.05 using paired ttest, compliance; p<0.01 for resistance. The results showed that anti-sense oligo II (SEQ. ID NO:7), which targets the adenosine Ai receptor, effectively maintains compliance and reduces resistance upon adenosine challenge.

Example 27: Antisense Oligos III and IV Oligos III (SEQ. ID NO:8) and IV (SEQ. ID NO:9) were shown to be in fact specifically targeted to the adenosine A 3 receptor by their effect on reducing inflammation and the number of inflammatory cells present upon separate administration of 20 mg of the anti-sense oligos III (SEQ. ID NO:8) and IV (SEQ. ID NO:9) to allergic rabbits as described above. The number of inflammatory cells was determined in their bronchial lavage fluid 3 hours later by counting at least 100 viable cells per lavage. The effect of anti-sense oligos III (SEQ. ID NO:8) and IV (SEQ. ID NO:9) upon granulocytes, and upon total cells in bronchial lavage were assessed following exposure to dust mite allergen.

The results showed that the anti-sense oligo IV (SEQ. ID NO:9) and anti-sense oligo III (SEQ. ID NO:8) are very potent anti-inflammatory agents in the asthmatic lung following exposure to dust mite allergen. As is known in the art, granulocytes, especially eosinophils, are the primary inflammatory cells of asthma, and the administration of anti-sense oligos III (SEQ. ID NO:8) 340 and IV (SEQ. ID NO:9) reduced their numbers by 40% and 66%, respectively. Furthermore, anti-sense oligos IV (SEQ. ID NO:9) and III (SEQ. ID NO:8) also reduced the total number of cells in the bronchial lavage fluid by 40% and 80%, respectively. This is also an important indicator of anti-inflammatory activity by the present anti-adenosine A 3 agents of the invention. Inflammation is known to underlie bronchial hyperresponsiveness and allergen-induced bronchoconstriction in asthma. Both anti-sense oligonucleotides III (SEQ. ID NO:8) and IV (SEQ. ID NO:9), which are targeted to the adenosine A 3 receptor, are representative of an important new class of anti-inflammatory agents which may be designed to specifically target the lung receptors of each species.

Example 28: Anti-sense Oligo V The anti-sense oligo V (SEQ. ID NO:10) targeted to the adenosine A2b adenosine receptor mRNA was shown to be highly effective at countering adenosine A 2 b-mediated effects and at reducing the number of adenosine A2b receptors present to less than half.

Example 29: Unexpected Superiority of Substituted over Phosphodiester-residue Oligo I-DS (SEQ. ID NO:1681) Oligos I (SEQ. ID NO:1) and I-DS (SEQ. ID NO:1681) were separately administered to allergic rabbits as described above, and the rabbits were then challenged with adenosine. The phosphodiester oligo I-DS (SEQ. ID NO:1681) was statistically significantly less effective in countering the effect of adenosine whereas oligo I (SEQ. ID NO:1) showed high effectiveness, evidencing a

PC

50 Adenosine of 20 mg.

Example 30: Anti-sense Oligo VI For the present work, I designed an additional antisense phosphorothioate oligo targeted to the adenosine Ai receptor (Oligo VI). This anti-sense oligo was designed for therapy on a selected species as described in the above patent application and is generally specific for that species, unless the segment of the adenosine receptor mRNA of other species elected happens to have a similar sequence. The anti-sense oligos were prepared as described below, and tested in vivo in a rabbit model for bronchoconstriction, inflammation and lung allergy, which have breathing difficulties and impeded lung airways, as 341 is the case in ailments such as asthma, as described in the above-identified application. One additional oligo and its effect in a rabbit model was studied and the results of the study are reported and discussed below.

The present oligo (anti-sense oligo VI) was selected for this study to complement the data on SEQ ID NO: 1 (Oligo which is anti-sense to the adenosine AI receptor mRNA provided in the above-identified patent application. This additional oligo is identified as anti-sense Oligo VI, and is targeted to a different region of the adenosine Ai receptor mRNA than Oligo I. The design and synthesis of this anti-sense oligo was performed in accordance with the teaching, particularly Example 1, of the aboveidentified patent application. The anti-sense Oligo VI is a phosphorothioate designed to target the coding region of the rabbit adenosine Ai receptor mRNA region +964 to +984 relative to the initiation codon (start site). The Oligo VI was prepared as described in the above-indicated application, and is 20 nucleotides long. The OligoVI is directed to the adenosine A, receptor gene, and has the following sequence: 5'-CGC CGG CGG GTG CGG GCC GG-3' (SEQ. ID The phosphorothioate anti-sense Oligo VI having the sequence described in above, was synthesized on an Applied Biosystems Model 396 Oligonucleotide Synthesizer, and purified using NENSORB chromatography (DuPont, DE). TETD (tetraethylthiuram disulfide) was used as the sulfurizing agent during the synthesis.

Example 31: Preparation of Allergic Rabbits Neonatal New Zealand white Pasturella-free rabbits were immunized intraperitoneally within 24 hours of birth with 0.5 ml of 312 antigen units/ml house dust mite (D.

farinae) extract (Berkeley Biologicals, Berkeley, CA) mixed with 10% kaolin as previously described (Metzger, W. in Late Phase Allergic Reactions, Dorsch, Ed., CRC Handbook, pp 347-362, CRC Press, Boca Raton, 1990; Ali, S. Et al., Am. J. Resp. Crit. Care Med. 149: 908 (1994)). The immunizations were repeated weekly for the first month and then bi-weekly until the animals were 4 months old. These rabbits preferentially produce allergen-specific IgE antibody, typically respond to aeroallergen challenge with both an early and late-phase asthmatic response, and show bronchial hyper 342 responsiveness (BHR). Monthly intraperitoneal administration of allergen (312 units dust mite allergen, as above) continues to stimulate and maintain allergenspecific IgE antibody and BHR. At 4 months of age, sensitized rabbits were prepared for aerosol administration as described by Ali et al. (1994), supra.

Example 32: Adenosine Aerosol Preparation An adenosine aerosol (20 mg/ml) was prepared with an ultrasonic nebulizer (Model 646, DeVilbiss, Somerset, PA), which produced aerosol droplets, 80% of which were smaller than 5:m in diameter. Equal volumes of the aerosols were administered directly to the lungs via an intratracheal tube to all three rabbits. The animals were then administered the aerosolized adenosine and Day 1 pre-treatment values for sensitivity to adenosine were calculated as the dose of adenosine causing a 50% loss of compliance (PCso Adenosine). The animals were then administered the aerosolized anti-sense via the intratracheal tube (5 mg/l.0 ml), for 2 minutes, twice daily for 2 days (total dose, 20 mg) Post-treatment PC 50 values were recorded (post-treatment challenge) on the morning of the third day. The results of these studies are provided in below.

Example 33: Anti-sense Oligo Formulation Each one of anti-sense oligos were separately solubilized in an aqueous solution and administered as described for anti-sense oligo I in above, in four mg aliquots (20 mg total dose) by means of a nebulizer via endotracheal tube, as described above.

Example 34: Oligo VI Reduces Response to Adenosine Challenge as well or Better than Oligo I Oligo VI was tested in three allergic rabbits of the characteristics and readied as described in above and in the above-indicated patent application. Oligo VI targets a section of the coding region of the Ai receptor which is different from Oligo I. Both these target sequences were selected randomly from many possible coding region target sequences. The three rabbits were treated identically as previously indicated for Oligo I.

Briefly, 5 mg of Oligo VI were nebulized to the rabbits twice per day at 8 hour intervals, for two days.

Thereafter, PC 50 adenosine studies were performed on the morning of the third day and compared to pre-treatment 343

PC

50 values. This protocol is described in more detail in Nyce and Metzger (Nyce Metzger, Nature 385: 721-725 (1997)). The results obtained for the three rabbits are shown in Table 7 below.

Table 7: PCs 0 Adenosine before after Aerosolized Adenosine Treatment Treatment Time PC 50 Adenosine (mg) Pre-treatment 3.0 +2.1 Post-treatment >20.0* maximum achievable dose due to adenosine insolubility in saline All three animals treated with Oligo VI completely eliminated sensitivity to adenosine up to the measurable level of the agent shown in Table 7 above. That is, the administration of the Oligo VI abrogated the adenosineinduced bronchoconstriction in the three allergic rabbits. The actual efficacy of Oligo VI is, therefore, greater than could be measured in the experimental system used. By comparing with the previously submitted results for the Oligo I, it may be seen that the Oligo VI was found to be as effective, or more, than Oligo I.

Example 34: Conclusions The work described and results discussed in the examples clearly indicates that all anti-sense oligonucleotides designed in accordance with the teachings of the above-identified application were found to be highly effective at countering or reducing effects mediated by the receptors they are targeted to. That is, each and all of the two anti-sense oligos targeting an adenosine Ai receptor mRNA, 1 anti-sense oligo targeting an adenosine A2b receptor mRNA, and the 2 anti-sense oligos targeting an A 3 receptor mRNA were shown capable of countering the effect of exogenously administered adenosine which is mediated by the specific receptor they are targeted to. The activity of the anti-sense oligos of this invention, moreover, is specific to the target and substitutively fails to inhibit another target. In addition, the results presented also show that the administration of the present agents results in extremely 344 low or non-existent deleterious side effects or toxicity.

This represents 100% success in providing agents that are highly effective and specific in the treatment of bronchoconstriction and/or inflammation. This invention is broadly applicable in the same manner to all gene(s) and corresponding mRNAs encoding proteins involved in or associated with airway diseases. A comparison of the phosphodiester and a version of the same oligonucleotide wherein the phosphodiester bonds are substituted with phosphorothioate bonds evidenced an unexpected superiority for the phosphothiorate oligonucleotide over the phosphodiester anti-sense oligo.

Example 35: In Vivo Response to Adenosine Challenge with without Oligo I Pretreatment Two hyper responsive monkeys (ascaris sensitive) were challenged with inhaled adenosine, with and without pre-treatment with anti-sense oligo I (SEQ.ID NO: The

PC

40 adenosine was calculated from the data collected as being equivalent to that amount of adenosine in mg that causes a 40% decrease in dynamic compliance in hyperresponsive airways. The Oligo I (SEQ. ID NO:1; EPI 2010) was subsequently administered at 10 mg/day for 2 days by inhalation. On the third day, the PC adenosine was again measured. The PC 40 adenosine value prior to treatment with Oligo I was compared side-by-side with to the adenosine taken after administration of Oligo I (Figure not shown). The results of the experiment conducted with two animals showed that any sensitivity to adenosine was completely eliminated by the administration of the oligo of this invention in one animal, and substantially reduced in the second.

Example 36: Extension of the experimental Results The method of the present invention is also practiced with anti-sense oligonucleotides targeted to many genes, mRNAs and their corresponding proteins as described above, in essentially the same manner as given above, for the treatment of various conditions in the lungs. Examples of these are Human A2a adenosine receptor, Human A2b adenosine receptor, Human IgE receptor Human Fc-epsilon receptor CD23 antigen (IgE receptor), Human IgE receptor, subunit, Human IgE receptor, Fc epsilon R, Human histidine decarboxylase, Human beta tryptase, Human tryptase-I, Human 345 prostaglandin D synthase, Human cyclooxygenase-2, Human eosinophil cationic protein, Human eosinophil derived neurotoxin, Human eosinophil peroxidase, Human intercellular adhesion molecule-1 (CAM-1), Human vascular cell adhesion molecule 1 (VCAM-1), Human endothelial leukocyte adhesion molecule (ELAM-1), Human P Selectin, Human endothelial monocyte activating factor, Human IL3, Human IL4, Human IL5, Human IL6, Human monocyte-derived neutrophil chemotactic factor, Human neutrophil elastase (medullasin), Human neutrophil oxidase factor, Human cathepsin G, Human defensin 1, Human defensin 3, Human macrophage inflammatory protein-i-alpha, Human muscarinic acetylcholine receptor HM1, Human muscarinic acetylcholine receptor HM3, Human fibronectin, Human interleukin 8, Human GM-CSF, Human tumor necrosis factor Human leukotriene C4 synthase, Human major basic protein, and many more.

The foregoing examples are illustrative of the present invention, and are not to be construed as limiting thereof. The invention is defined by the following claims, with equivalents of the claims to be included therein.

346

Claims (76)

1. A pharmaceutical composition, comprising an oligonucleotide(s) (oligo(s)) which is (are) effective for alleviating bronchoconstriction and/or lung inflammation, allergy(ies), or surfactant depletion or hyposecretion, when administered to a mammal, the oligo containing about 0 to about 15% adenosine and being anti-sense to a target selected from the group consisting of the initiation codon, the coding region, the and the 3'-end genomic flanking regions, the 5' and 3' intron-exon junctions, and regions within 2 to nucleotides of the junctions of a gene encoding a target polypeptide associated with lung airway dysfunction or anti-sense to the polypeptide mRNA; combinations of the oligos; and mixtures of the oligos; and a pharmaceutically or veterinarily acceptable carrier or diluent.

2. The composition of claim 1, wherein the oligo is A-free.

3. The composition of claim 1, wherein the target is selected from the group consisting of the initiation codon, the coding region, the 5'-end and the 3'-end genomic flanking regions, the 5' and 3' intron-exon junctions, and regions within 2 to 10 nucleotides of the junctions of an oncogene(s) and a gene(s) encoding a target polypeptide(s) associated with lung airway dysfunction or anti-sense to the oncogene mRNA and the polypeptide mRNA; combinations of the oligos; and mixtures of the oligos; the polypeptides being selected from the group consisting of peptide factors and transmitters, antibodies, cytokines and chemokines, enzymes, binding proteins, adhesion molecules, their receptors, and malignancy associated proteins.

4. The composition of claim 3, wherein the target is selected from the group consisting of the initiation codon, the coding region, the 5'-end and the 3'-end genomic flanking regions, the 5' and 3' intron-exon junctions, and regions within 2 to 10 nucleotides of the junctions of an oncogene(s) and a gene(s) encoding a target polypeptide(s) associated with lung airway dysfunction or anti-sense to the oncogene mRNA and the polypeptide mRNA; combinations of the oligos; and mixtures of the oligos; wherein the polypeptides are 347 selected from the group consisting of transcription factors, stimulating and activating peptide factors, cytokines, cytokine receptors, chemokines, chemokine receptors, adenosine receptors, bradykinin receptors, endogenously produced specific and non-specific enzymes, immunoglobulins and antibodies, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non-nervous system peptide transmitters, adhesion molecules, defensins, growth factors, vasoactive peptides and receptors, binding proteins, and malignancy associated proteins. The agent of claim 4, wherein the encoded polypeptide(s) is(are) selected from the group consisting of adenosine receptors Al, A2a, A2b and A3, bradykinin receptors B1 and B2, Nf6B Transcription Factor, Interleukin-8 Receptor (IL-8 Interleukin 5 Receptor Interleukin 4 Receptor (IL-4 Interleukin 3 Receptor (IL-3 Interleukin-l6,a Interleukin Receptor (IL- 1l6' Eotaxin, Tryptase, Major Basic Protein, 4w2-adrenergic Receptor Kinase, Endothelin Receptor A, Endothelin Receptor B, Preproendothelin, Bradykinin B2 Receptor, IgE High Affinity Receptor, Interleukin 1 Interleukin 1 Receptor (IL-1 R), Interleukin 9 Interleukin-9 Receptor (IL-9 R), Interleukin 11 (IL-11), Interleukin-11 Receptor (IL-11 Inducible Nitric Oxide Synthase, Cyclo-oxygenase-1 (COX-1), Cyclo-oxygenase-2 (COX-2), Intracellular Adhesion Molecule 1 (ICAM-1) Vascular Cellular Adhesion Molecule (VCAM), Rantes, Endothelial Leukocyte Adhesion Molecule (ELAM-1), Monocyte Activating Factor, Neutrophil Chemotactic Factor, Neutrophil Elastase, Defensin 1, 2 and 3, Muscarinic Acetylcholine Receptors, Platelet Activating Factor, Tumor Necrosis Factor lipoxygenase, Phosphodiesterase IV, Substance P, Substance P Receptor, Histamine Receptor, Chymase, CCR-1 CC Chemokine Receptor, CCR-2 CC Chemokine Receptor, CCR-3 CC Chemokine Receptor, CCR-4 CC Chemokine Receptor, CC Chemokine Receptor, Prostanoid Receptors, GATA-3 Transcription Factor, Neutrophil Adherence Receptor, MAP Kinase, Interleukin-9 NFAT Transcription Factors, STAT 4, MIP-1<, MCP-2, MCP-3, MCP-4, Cyclophillins, Phospholipase A2, Basic Fibroblast Growth Factor, 348 Metalloproteinase, CSBP/p38 MAP Kinase, Tryptose Receptor, PDG2, Interleukin-3 Interleukin-lor Cyclosporin A-Binding Protein, Protein, <4c-1 Selectin, Fibronectin, X<44s7 Selectin, Mad CAM-1, LFA-1 (CD11a/CD18), PECAM-1, LFA-1 Selectin, C3bi, PSGL-1, E-Selectin, P-Selectin, CD-34, L-Selectin, p150,95, Mac-i (CD11b/CD18), Fucosyl transferase, VLA-4, CD-18/CD11a, CD11b/CD18, ICAM2 and ICAM3, C5a, CCR3 (Eotaxin Receptor), CCR1, CCR2, CCR4, CCR5, LTB-4, AP-1 Transcription Factor, Protein kinase C, Cysteinyl Leukotriene Receptor, Tachychinnen Receptors (tach R), I6B Kinase 1 2, STAT 6, c-mas and NF-Interleukin-6 (NF- IL-6)

6. The composition of claim 1, wherein one or more As is(are) substituted by a universal base selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist or antagonist activity at the adenosine A2a, A2b and A 3 receptors.

7. The composition of claim 6, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by O, halo, NH 2 SH, SO, S02, SO 3 COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by O, halo, NH 2 primary, secondary and tertiary amine, SH, SO, SO 2 SO 3 cycloalkyl, heterocycloalkyl and heteroaryl.

8. The composition of claim 7, wherein the pyrimidines and purines are substituted at a position selected from the group consisting of positions 1, 2, 3, 4, 7, and 8, and the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula 349 wherein R 1 and R 2 are independently H, alkyl, alkenyl or alkynyl and R 3 is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, O-cycloalkyl, O-cycloalkenyl, O- cycloalkynyl, NH 2 -alkylamino-ketoxyalkyloxy-aryl and mono and dialkylaminoalkyl-N-alkylamino-S0 2 aryl.

9. The composition of claim 8, wherein the universal base is selected from the group consisting of 3-nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2- nitroindole), 2'-deoxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyrimido oxazine-7-one or 2-amino- 6-methoxyaminopurine. The composition of claim 1, where one or more methylated cytocine(s) m C) is(are) substituted for a C in one or more CpG dinocleotide(s), if present in the oligo(s).

11. The composition of claim 1, wherein one or more mononucleotide(s) of the oligo(s) is(are) linked or modified by one or more methylphosphonate, carbamate, phosphotriester, phosphorothioate, phosphorodithioate, boranophosphate, formacetal, thioformacetal, thioether, carbonate, carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, sulfoxide, sulfide, hydroxylamine, methylene(methyimino) (MMI), methoxymethyl (MOM), methoxyethyl (MOE), methyleneoxy (methylimino) (MOMI), 2'-O-methyl, phosphoramidate, C-5 substituted residues, or combinations thereof.

12. The composition of claim 11, wherein the mononucleotide residues are linked by phosphorothioate residues.

13. The composition of claim 1, wherein the anti- sense oligo comprises about 7 to about mononucleotides.

14. The composition of claim 1, wherein the anti- sense oligo comprises fragments 1, 3, 5, 7 and 8 to 2313 (SEQ. ID NOS: 1 through 2419). The composition of claim 1, wherein the anti- 350 sense oligo is operatively linked to, or complexed with, an agent selected from the group consisting of cell internalized or up-taken agents and cell targeting agents.

16. The composition of claim 15, wherein the cell internalized or up-taken agent is selected from the group consisting of transferrin, asialoglycoprotein and streptavidin.

17. The composition of claim 1, wherein the oligo is operatively linked to a vector that is a prokaryotic or eukaryotic vector.

18. The composition of claim 1, wherein the oligo(s) is(are) hybridized to a ribonucleic acid.

19. A cell, carrying the oligo of claim 1.

20. The composition of claim 1, wherein the carrier or diluent is selected from the group consisting of gaseous, liquid, and solid carriers or diluents.

21. The composition of claim 20, further comprising an agent selected from the group consisting of other therapeutic agents, surfactants, flavoring and coloring agents, fillers, volatile oils, buffering agents, dispersants, RNA inactivating agents, anti-oxidants, flavoring agents, propellants and preservatives.

22. The composition of claim 21, comprising one or more oligo(s), a surfactant, and a carrier or diluent for the oligo and the surfactant.

23. The composition of claim 21, wherein the the agent is an RNA inactivating agent which comprises an enzyme, optionally an ribozyme.

24. The composition of claim 1, wherein the anti- sense oligo is present in an amount of about 0.01 to about 99.99 w/w of the composition. The composition of claim 1, which is a systemic or topical formulation.

26. The formulation of claim 25, selected from the group consisting of oral, intrabuccal, intrapulmonary, rectal, intrauterine, intratunor, intracranial, nasal, intramuscular, subcutaneous, intravascular, intrathecal, inhalable, transdermal, intradermal, intracavitary, implantable, iontophoretic, ocular, vaginal, intraarticular, otical, intravenous, intramuscular, intraglandular, intraorgan, intralymphatic, implantable, slow release and enteric coating formulations. 351

27. The formulation of claim 26, which is an oral formulation, wherein the carrier is selected from the group consisting of solid and liquid carriers.

28. The oral formulation of claim 27, which is selected from the group consisting of a powder, dragees, tablets, capsules, sprays, aerosols, solutions, suspensions and emulsions, optionally oil-in-water and water-in-oil emulsions.

29. The formulation of claim 25, which is a topical formulation, wherein the carrier is selected from the group consisting of creams, gels, ointments, sprays, aerosols, patches, solutions, suspensions and emulsions. The formulation of claim 26, which is an injectable formulation, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions and suspensions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions.

31. The formulation of claim 26, which is a rectal formulation, optionally a suppository.

32. The formulation of claim 26, which is a transdermal formulation, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions, oily solutions and suspensions and oil-in- water and water-in-oil emulsions.

33. The transdermal formulation of claim 32, which is an iontophoretic transdermal formulation, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions, and wherein the formulation further comprises a transdermal transport promoting agent.

34. The formulation of claim 26, which is provided in an implant, a capsule or a cartridge. The composition of claim 20, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions and suspensions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions.

36. The formulation of claim 20, wherein the carrier comprises a hydrophobic carrier.

37. The formulation of claim 36, wherein the carrier comprises lipid vesicles, optionally liposomes, or particles, optionally microcrystals. 352

38. The formulation of claim 37, wherein the carrier comprises liposomes, and the liposomes comprise the anti-sense oligo.

39. The formulation of claim 26, which is a respirable or inhalable formulation, optionally an aerosol. The composition of claim 1, in single or multiple unit form.

41. The composition of claim 1, in bulk.

42. A kit, comprising a delivery device; in a separate container(s), the oligo(s) of claim 1; and instructions for adding a carrier and for use of the kit.

43. The kit of claim 42, wherein the formulation is a respirable formulation and the delivery device comprises a nebulizer which delivers single metered doses of the formulation.

44. The kit of claim 43, wherein the nebulizer comprises an insufflator and the composition is provided in a piercable or openable capsule or cartridge. The kit of claim 44, wherein the delivery device comprises a pressurized inhaler and the composition comprises a suspension, solution or dry formulation of the oligo.

46. The kit of claim 45, further comprising, in a separate container, an agent selected from the group consisting of other therapeutic agents, surfactants, anti-oxidants, flavoring agents, fillers, volatile oils, dispersants, antioxidants, propellants, preservatives, buffering agents, RNA inactivating agents, cell- internalized or up-taken agents and coloring agents.

47. The kit of claim 46, comprising, in separate containers, one or more oligos, one or more surfactants, and a carrier or diluent, and optionally other therapeutic agents.

48. The kit of claim 42, wherein the device is a transdermal delivery device, and the kit further comprises a transdermal delivery agent, a transdermal carrier or diluent, and instructions for preparing a transdermal delivery formulation.

49. The kit of claim 42, wherein the device is an 353 iontophoretic delivery device, and the kit further comprises iontophoretic agents and instructions for preparing an iontophoretic formulation. An in vivo method of delivering an anti-sense oligonucleotide(s) (oligo(s)) to one or more target polynucleotide(s), comprising administering into the respiratory system of a subject one or more oligo(s) that are anti-sense to the polynucleotide(s), in an amount effective to reach and hybridize to the target polynucleotide(s), and reduce the production or availability, or to increase the degradation, of the target mRNA, or to reduce the amount of the target polypeptide present in the lungs.

51. An in vivo method of delivering an anti-sense oligonucleotide (oligo) to a target polynucleotide associated with bronchoconstriction and/or lung inflammation, allergy(ies) and/or surfactant hypoproduction, comprising administering to a subject the composition of claim 1, that comprises an amount of the oligo(s) effective to reach and hybridize to the target polynucleotide(s), and reduce or inhibit the polynucleotide(s), transcription and/or expression and, thereby, alleviating bronchoconstriction and/or lung inflammation, allergy(ies) and/or surfactant hypoproduction.

52. The method of claim 51, wherein the administered composition comprises an amount of the oligo(s) and is administered under conditions effective for alleviating bronchoconstriction and/or lung inflammation, allergy(ies) and/or surfactant depletion or hyposecretion, when administered to a mammal.

53. The method of claim 51, wherein the composition is administered into the subject's respiratory system.

54. The method of claim 53, wherein the composition is administered directly into the subject's lung The method of claim 51, wherein the administered composition comprises an amount of the oligo(s) and is administered under conditions effective to reduce the production or availability, or to increase the degradation, of the target mRNA or to reduce the amount of the target polypeptide present in the lungs.

56. The method of claim 51, wherein the agent is 354 I administered as a respirable aerosol.

57. The method of claim 51, wherein the pulmonary obstruction, and/or bronchoconstriction and\or lung inflammation, allergy(ies) and/or surfactant hypoproduction are associated with a disease or condition selected from the group consisting of pulmonary vasoconstriction, inflammation, allergies, asthma, impeded respiration, respiratory distress syndrome (RDS), pain, cystic fibrosis allergic rhynitis (AR), pulmonary hypertension, emphysema, chronic obstructive pulmonary disease (COPD), pulmonary transplantation rejection, pulmonary infections, bronchitis, and cancer.

58. The method of claim 57, wherein the disease or condition is associated with an allergy(ies), and the oligo is anti-sense to a target selected from the group consisting of the initiation codon,the coding region, the and the 3'-end genomic flanking regions, the and 3' intron-exon junctions, and regions within 2 to nucleotides of the junctions of a gene(s) encoding an immunoglobulin(s) and antibody(ies) and immunoglobulin and antibody receptors or are anti-sense to the immunoglobulin(s) and antibody(ies) and immunoglobulin and antibody receptors mRNA; combinations of the oligo(s); and mixtures of the oligos.

59. The method of claim 57, wherein the disease or condition is associated with a malignancy or cancer, and the oligo is anti-sense to a target selected from the group consisting of the initiation codon,the coding region, the 5'-end and the 3'-end genomic flanking regions, the 5' and 3' intron-exon junctions, and regions within 2 to 10 nucleotides of the junctions of an oncogene(s) and\or encodes a malignancy associated protein, or is(are) anti-sense to the oncogene or malignancy associated protein mRNA; combinations of the oligo(s); and mixtures of the oligos and the oligo(s) is(are) administered in an amount effective to reduce either the level of the protein mRNA or of the malignancy associated protein, or to reduce the growth of or provide beneficial characteristics to malignant cells.

60. The method of claim 51, wherein the composition is administered transdermally or systemically.

61. The method of claim 60, wherein the composition is administered orally, intracavitarily, intranasally, 355 intraanally, intravaginally, intrauterally, intraarticularly, transdermally, intrabucally, intravenously, subcutaneously, intramuscularly, intravascularly, intratumorously, intraglandularly, intraocularly, intracranial, into an organ, intravascularly, intrathecally, intralymphatically, intraotically, by implantation, by inhalation, intradermally, intrapulmonarily, intraotically, by slow release, by sustained release and by a pump.

62. The method of claim 51, wherein the subject is a non-human mammal.

63. The method of claim 51, wherein the mammal is a human.

64. The method of claim 51, wherein the oligo is administered in amount of about 0.005 to about 150 mg/kg body weight. The method of claim 51, wherein the oligo is obtained by selecting fragments of a target nucleic acid having at least 4 contiguous nucleic acids selected from the group consisting of G and C; obtaining a first oligonucleotide 4 to nucleotides long which comprises the selected fragment and has a C and G nucleic acid content of up to and including about 15%; and obtaining a second oligonucleotide 4 to nucleotides long comprising a sequence which is anti- sense to the. selected fragment, the second oligonucleotide having an A base content of up to and including about The method of claim 64, wherein the oligo is A- free.

66. The method of claim 51, wherein the target is selected from the group consisting of the initiation codon, the coding region, the 5'-end and the 3'-end genomic flanking regions, the 5' and 3' intron-exon junctions, and regions within 2 to 10 nucleotides of the junctions of an oncogene or a gene encoding a target polypeptide associated with lung airway dysfunction or anti-sense to the polypeptide or oncogene mRNA; combinations of the oligo(s); and mixtures of the oligos; wherein the polypeptide isselected from the group consisting of transcription factors, stimulating and 356 activating factors, interleukins, interleukin receptors, chemokines, chemokine receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non-nervous system peptide transmitters, adhesion molecules, defensines, growth factors, vasoactive peptides, peptide receptors and binding proteins, and malignancy associated proteins.

67. The method of claim 51, wherein one or more As in the oligo(s) is(are) substituted by a universal base selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have less than about 0.3 of the adenosine base agonist or antagonist activity at an adenosine A2a, A2b and A 3 receptors.

68. The method of claim 67, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by 0, halo, NH 2 SH, SO, SO 2 SO 3 COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by O, halo, NH 2 primary, secondary and tertiary amine, SH, SO, SO 2 SO 3 cycloalkyl, heterocycloalkyl and heteroaryl.

69. The method of claim 67, wherein the pyrimidines and purines are substituted at positions 1, 2, 3, 4, 7 and 8 and the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula wherein R 1 and R 2 are independently H, alkyl, alkenyl or alkynyl and R 3 is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, O-cycloalkyl, 0-cycloalkenyl, 0- cycloalkynyl, NH 2 -alkylamino-ketoxyalkyloxy-aryl and mono and dialkylaminoalkyl-N-alkylamino-S0 2 aryl. The method of claim 69, wherein the universal base is selected from the group consisting of 3- 357 nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2- nitroindole), 2'-deoxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyrimido oxazine-7-one or 2-amino- 6-methoxyaminopurine.

71. The method of claim 51, further comprising substituting a methylated cytocine m C) for a C in one or more CpG dinucleotide(s), if present in the oligo(s).

72. The method of claim 51, further comprising substituting by, or modifying one or more nucleotide residue(s) of the oligo(s) with, methylphosphonate, phosphotriester, phosphorothioate, phosphorodithioate, boranophosphate, formacetal, thioformacetal, thioether, carbonate, carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, sulfoxide, sulfide, hydroxylamine, methylene(methyimino) (MMI), methoxymethyl (MOM), methoxyethyl (MOE), methyleneoxy (methylimino) (MOMI), methoxy methyl (MOM), 2'-O-methyl, phosphoramidate, C-5 substituted residues, or combinations thereof.

73. The method of claim 51, further comprising operatively linking to, or complexing the oligo(s) with, an agent selected from the group consisting of cell internalized and up-taken agent(s) and cell targeting agents.

74. The method of claim 73, wherein the cell internalized or up taken agent is selected from the group consisting of transferrin, asialoglycoprotein, and streptavidin.

75. The method of claim 73, wherein the cell targeting agent is a vector, optionally a prokaryotic or eukaryotic vector.

76. A method of treating a disease or condition associated with a target selected associated with a disease or condition afflicting lung airways, comprising conducting the method of claim 56.

77. The method of claim 76, wehrein the amount of oligo(s) administered is (are) effective to reduce the production or availability, or to increase the degradation, of the mRNA, or to reduce the amount of the polypeptide present in the lungs.

78. The method of claim 77, wherein the amount of oligo(s) administered is (are) effective to reduce the 358 production or availability, or to increase the degradation, of the mRNA, or to increase the amount of the surfactant present in the subject's lungs.

79. The composition of claim 4, wherein the oligo(s) is(are) anti-sense to the initiation codon, the coding region, the 5'-end and the 3'-end genomic flanking regions, the 5' and 3' intron-exon junctions, and regions within 2 to 10 nucleotides of the junctions of a gene(s) encoding an adenosine Al, A2a, A2b and\or A3 receptor, or anti-sense to the adenosine Al, A2a, A2b and\or A3 receptor mRNA. The composition of claim 79, wherein all nucleotide linking residues are phosphorothioates.

81. The composition of claim 1, wherein the oligo is a DNA.

82. The composition of claim 1, wherein the oligo is an RNA.

83. The composition of claim 1, wherein the oligo comprises about 7 to up to about 60 mononucleotides.

84. The composition of claim 79, wherein the oligo(s) is selected from the group consisting of fragment(s) SEQ ID NOS: 1, 3, 5, 7, 8, and\or 11 through 2419, optionally wherein at least one mononucleotide residue is substituted or modified by methylphosphonate, phosphotriester, phosphorothioate, phosphorodithioate, boranophosphate, formacetal, thioformacetal, thioether, carbonate, carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, sulfoxide, sulfide, hydroxylamine, methylene(methyimino), (MMI), methoxymethyl (MOM), methoxyethyl (MOE), methyleneoxy (methylimino) (MOMA), methoxy methyl (MOM), 2'-O-methyl, phosphoramidate residues and/or combinations thereof. The method of claim 51, wherein the oligo is administered topically to the airway, respiratory or pulmonary epithelium of the subject.

86. The composition of claim 1, wherein the oligo has a particle size of about 5-10 Bm or in the range of 10-500 Rm.

87. The composition of claim 1, further comprising a propellant.

88. The method of claim 50, wherein the oligo has a particle size of about 5-10 Bm or in the range of 10-500 Bm. 359

89. The method of claim 50, further comprising adding to the oligo a propellant. The method of claim 51, wherein the oligo has a particle size of about 5-10 Qm or in the range of 10-500 m.

91. The method of claim 51, further comprising adding to the oligo a propellant. Dated this 28th day of June 2002 EAST CAROLINA UNIVERSITY By their Patent Attorneys GRIFFITH HACK Fellows Institute of Patent and Trade Mark Attorneys of Australia 360