AU4947997A - Phenyl-substituted bicyclic heterocyclyl derivatives and their use - Google Patents

Phenyl-substituted bicyclic heterocyclyl derivatives and their use

Info

Publication number
AU4947997A
AU4947997A AU49479/97A AU4947997A AU4947997A AU 4947997 A AU4947997 A AU 4947997A AU 49479/97 A AU49479/97 A AU 49479/97A AU 4947997 A AU4947997 A AU 4947997A AU 4947997 A AU4947997 A AU 4947997A
Authority
AU
Australia
Prior art keywords
phenyl
bicyclic heterocyclyl
substituted bicyclic
heterocyclyl derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU49479/97A
Inventor
Pascal Furet
Jennifer Mary Green
Urs Sequin
Peter Traxler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Publication of AU4947997A publication Critical patent/AU4947997A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/233Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU49479/97A 1996-10-18 1997-10-16 Phenyl-substituted bicyclic heterocyclyl derivatives and their use Abandoned AU4947997A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9621757 1996-10-18
GBGB9621757.5A GB9621757D0 (en) 1996-10-18 1996-10-18 Phenyl-substituted bicyclic heterocyclyl derivatives and their use
PCT/EP1997/005697 WO1998017662A1 (en) 1996-10-18 1997-10-16 Phenyl-substituted bicyclic heterocyclyl derivatives and their use

Publications (1)

Publication Number Publication Date
AU4947997A true AU4947997A (en) 1998-05-15

Family

ID=10801645

Family Applications (1)

Application Number Title Priority Date Filing Date
AU49479/97A Abandoned AU4947997A (en) 1996-10-18 1997-10-16 Phenyl-substituted bicyclic heterocyclyl derivatives and their use

Country Status (3)

Country Link
AU (1) AU4947997A (en)
GB (1) GB9621757D0 (en)
WO (1) WO1998017662A1 (en)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE332896T1 (en) 1997-10-27 2006-08-15 Agouron Pharma 4-AMINOTHIAZOLE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES
FR2781154B1 (en) * 1998-07-15 2001-09-07 Lafon Labor THERAPEUTIC COMPOSITION BASED ON ISOFLAVONOIDS FOR USE IN THE TREATMENT OF TUMORS WITH CYTOTOXIC AGENTS
FR2797444B1 (en) * 1999-08-13 2003-02-07 Lafon Labor PHARMACEUTICAL COMPOSITIONS COMPRISING 4-QUINOLONES
YU54202A (en) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Indazole compounds,pharmaceutical compositions,and methods for mediating or inhibiting cell proliferation
HN2001000008A (en) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals AMIDA COMPOSITE AND PHARMACEUTICAL COMPOSITIONS TO INHIBIT PROTEINKINASES, AND THE INSTRUCTIONS FOR USE
WO2001079198A1 (en) 2000-04-18 2001-10-25 Agouron Pharmaceuticals, Inc. Pyrazoles for inhibiting protein kinase
KR100399364B1 (en) * 2000-09-18 2003-09-26 주식회사 엘지생명과학 3-Hydroxy-6-aminochromene-4-on derivatives useful as cyclin dependendent kinase inhibitors
US6683095B2 (en) 2000-05-03 2004-01-27 Lg Life Sciences Ltd. CDK inhibitors having 3-hydroxychromen-4-one structure
MXPA03001189A (en) 2000-08-09 2004-05-14 Agouron Pharma Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases.
ATE295354T1 (en) 2000-08-18 2005-05-15 Agouron Pharma HETEROCYCLIC HYDROXIMINO FLUORENES AND THEIR USE FOR INHIBITING PROTEIN KINASES
FR2813791B1 (en) * 2000-09-14 2004-03-12 Lafon Labor USE OF 2- AND 4-QUINOLONES TO INHIBIT INTIMAL NEO-PROLIFERATION
GB0030729D0 (en) * 2000-12-16 2001-01-31 Univ Nottingham Substituted-4-Quinolones
AUPR846401A0 (en) * 2001-10-25 2001-11-15 Novogen Research Pty Ltd 6-Hydroxy isoflavones, derivatives and medicaments involving same
AU2003265737B2 (en) * 2002-10-02 2008-10-16 Novogen Research Pty Ltd Combination chemotherapy compositions and methods
AU2002951833A0 (en) * 2002-10-02 2002-10-24 Novogen Research Pty Ltd Compositions and therapeutic methods invloving platinum complexes
CN100378105C (en) * 2003-01-31 2008-04-02 中国人民解放军南京军区联勤部军事医学研究所 Pyran isoflavone molluscacide synthesizing method and formulation
US7547794B2 (en) 2003-04-03 2009-06-16 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
US7601855B2 (en) 2004-09-21 2009-10-13 Novogen Research Pty Ltd Substituted chroman derivatives, medicaments and use in therapy
EP1856083A4 (en) * 2005-03-11 2009-05-27 Univ Michigan Chromen-4-one inhibitors of anti-apoptotic bcl-2 family members and the uses thereof
EP1886996A1 (en) * 2006-08-10 2008-02-13 Ferrer Internacional, S.A. 1H-Quinolin-4-one compounds, with affinity for the GABA receptor, processes, uses and compositions
AU2007283570A1 (en) * 2006-08-10 2008-02-14 Ferrer Internacional S.A. 1H-quinolin-4-one compounds, with affinity for the GABA receptor, processes, uses and compositions
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
WO2009026657A1 (en) * 2007-08-29 2009-03-05 The University Of Sydney Flavonoid ppar agonists
MX2011004824A (en) 2008-11-07 2012-01-12 Triact Therapeutics Inc Use of catecholic butane derivatives in cancer therapy.
WO2010064701A1 (en) * 2008-12-05 2010-06-10 大塚製薬株式会社 Pharmaceutical agent comprising quinolone compound
TWI492943B (en) 2008-12-05 2015-07-21 大塚製藥股份有限公司 Quinolone compound and pharmaceutical composition
WO2010099139A2 (en) 2009-02-25 2010-09-02 Osi Pharmaceuticals, Inc. Combination anti-cancer therapy
WO2010099137A2 (en) 2009-02-26 2010-09-02 Osi Pharmaceuticals, Inc. In situ methods for monitoring the emt status of tumor cells in vivo
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010099363A1 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
JP2012519282A (en) 2009-02-27 2012-08-23 オーエスアイ・ファーマシューティカルズ,エルエルシー Methods for identifying mesenchymal tumor cells or agents that inhibit their production
WO2010107968A1 (en) 2009-03-18 2010-09-23 Osi Pharmaceuticals, Inc. Combination cancer therapy comprising administration of an egfr inhibitor and an igf-1r inhibitor
JP2013510564A (en) 2009-11-13 2013-03-28 パンガエア ビオテック、ソシエダッド、リミターダ Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
EP2635121B1 (en) 2010-11-01 2020-01-08 MEI Pharma, Inc. Isoflavonoid compounds and methods for the treatment of cancer
EP2468883A1 (en) 2010-12-22 2012-06-27 Pangaea Biotech S.L. Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
US9134297B2 (en) 2011-01-11 2015-09-15 Icahn School Of Medicine At Mount Sinai Method and compositions for treating cancer and related methods
EP2492688A1 (en) 2011-02-23 2012-08-29 Pangaea Biotech, S.A. Molecular biomarkers for predicting response to antitumor treatment in lung cancer
WO2012129145A1 (en) 2011-03-18 2012-09-27 OSI Pharmaceuticals, LLC Nscle combination therapy
US9896730B2 (en) 2011-04-25 2018-02-20 OSI Pharmaceuticals, LLC Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
WO2013033380A1 (en) 2011-08-31 2013-03-07 Genentech, Inc. Diagnostic markers
AU2012321248A1 (en) 2011-09-30 2014-04-24 Genentech, Inc. Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to EGFR kinase inhibitor in tumours or tumour cells
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
WO2013190089A1 (en) 2012-06-21 2013-12-27 Pangaea Biotech, S.L. Molecular biomarkers for predicting outcome in lung cancer
CN105017145B (en) * 2012-12-12 2017-12-05 王子厚 7-chloro-4-oxo-quinoline derivative with antitumor activity
JP6255038B2 (en) 2013-02-26 2017-12-27 トリアクト セラピューティクス,インク. Cancer treatment
EP2976085A1 (en) 2013-03-21 2016-01-27 INSERM - Institut National de la Santé et de la Recherche Médicale Method and pharmaceutical composition for use in the treatment of chronic liver diseases associated with a low hepcidin expression
EP3044593A4 (en) 2013-09-09 2017-05-17 Triact Therapeutics, Inc. Cancer therapy
WO2015156674A2 (en) 2014-04-10 2015-10-15 Stichting Het Nederlands Kanker Instituut Method for treating cancer
CA2969830A1 (en) 2014-12-24 2016-06-30 Genentech, Inc. Therapeutic, diagnostic and prognostic methods for cancer of the bladder
HUE054998T2 (en) 2015-02-02 2021-10-28 Mei Pharma Inc Combination therapies for use in the treatment of breast cancer
LT3558955T (en) 2016-12-22 2021-11-10 Amgen Inc. Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer
JOP20190272A1 (en) 2017-05-22 2019-11-21 Amgen Inc Kras g12c inhibitors and methods of using the same
TWI731264B (en) 2017-09-08 2021-06-21 美商安進公司 Inhibitors of kras g12c and methods of using the same
MX2020011582A (en) 2018-05-04 2020-11-24 Amgen Inc Kras g12c inhibitors and methods of using the same.
JP7266043B2 (en) 2018-05-04 2023-04-27 アムジエン・インコーポレーテツド KRas G12C inhibitors and methods of using them
JP7361720B2 (en) 2018-05-10 2023-10-16 アムジエン・インコーポレーテツド KRAS G12C inhibitors for the treatment of cancer
EP3802535B1 (en) 2018-06-01 2022-12-14 Amgen, Inc Kras g12c inhibitors and methods of using the same
AU2019284472B2 (en) 2018-06-11 2024-05-30 Amgen Inc. KRAS G12C inhibitors for treating cancer
AU2019336588B2 (en) 2018-06-12 2022-07-28 Amgen Inc. KRAS G12C inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer
CN113194954A (en) 2018-10-04 2021-07-30 国家医疗保健研究所 EGFR inhibitors for the treatment of keratoderma
JP2020090482A (en) 2018-11-16 2020-06-11 アムジエン・インコーポレーテツド Improved synthesis of key intermediate of kras g12c inhibitor compound
EP3883565A1 (en) 2018-11-19 2021-09-29 Amgen Inc. Kras g12c inhibitors and methods of using the same
JP7377679B2 (en) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド Combination therapy comprising a KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancer
ES2953821T3 (en) 2018-12-20 2023-11-16 Amgen Inc KIF18A inhibitors
US20220056015A1 (en) 2018-12-20 2022-02-24 Amgen Inc. Kif18a inhibitors
US11236069B2 (en) 2018-12-20 2022-02-01 Amgen Inc. KIF18A inhibitors
WO2020132653A1 (en) 2018-12-20 2020-06-25 Amgen Inc. Heteroaryl amides useful as kif18a inhibitors
AU2020232616A1 (en) 2019-03-01 2021-09-09 Revolution Medicines, Inc. Bicyclic heterocyclyl compounds and uses thereof
EP3931195A1 (en) 2019-03-01 2022-01-05 Revolution Medicines, Inc. Bicyclic heteroaryl compounds and uses thereof
EP3738593A1 (en) 2019-05-14 2020-11-18 Amgen, Inc Dosing of kras inhibitor for treatment of cancers
US11236091B2 (en) 2019-05-21 2022-02-01 Amgen Inc. Solid state forms
WO2021026099A1 (en) 2019-08-02 2021-02-11 Amgen Inc. Kif18a inhibitors
JP2022542394A (en) 2019-08-02 2022-10-03 アムジエン・インコーポレーテツド Heteroarylamides useful as KIF18A inhibitors
CA3146693A1 (en) 2019-08-02 2021-02-11 Amgen Inc. Kif18a inhibitors
CN114391012A (en) 2019-08-02 2022-04-22 美国安进公司 Pyridine derivatives as KIF18A inhibitors
WO2021081212A1 (en) 2019-10-24 2021-04-29 Amgen Inc. Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer
EP4054719A1 (en) 2019-11-04 2022-09-14 Revolution Medicines, Inc. Ras inhibitors
CN114867735A (en) 2019-11-04 2022-08-05 锐新医药公司 RAS inhibitors
CN115873020A (en) 2019-11-04 2023-03-31 锐新医药公司 RAS inhibitors
KR20220100903A (en) 2019-11-08 2022-07-18 레볼루션 메디슨즈, 인크. Bicyclic heteroaryl compounds and uses thereof
IL292315A (en) 2019-11-14 2022-06-01 Amgen Inc Improved synthesis of kras g12c inhibitor compound
AU2020383535A1 (en) 2019-11-14 2022-05-05 Amgen Inc. Improved synthesis of KRAS G12C inhibitor compound
EP4065231A1 (en) 2019-11-27 2022-10-05 Revolution Medicines, Inc. Covalent ras inhibitors and uses thereof
TW202140011A (en) 2020-01-07 2021-11-01 美商銳新醫藥公司 Shp2 inhibitor dosing and methods of treating cancer
IL299131A (en) 2020-06-18 2023-02-01 Revolution Medicines Inc Methods for delaying, preventing, and treating acquired resistance to ras inhibitors
MX2023002248A (en) 2020-09-03 2023-05-16 Revolution Medicines Inc Use of sos1 inhibitors to treat malignancies with shp2 mutations.
PE20231207A1 (en) 2020-09-15 2023-08-17 Revolution Medicines Inc INDOLIC DERIVATIVES AS RAS INHIBITORS IN CANCER TREATMENT
CN117396472A (en) 2020-12-22 2024-01-12 上海齐鲁锐格医药研发有限公司 SOS1 inhibitors and uses thereof
AR125782A1 (en) 2021-05-05 2023-08-16 Revolution Medicines Inc RAS INHIBITORS
AU2022268962A1 (en) 2021-05-05 2023-12-14 Revolution Medicines, Inc. Ras inhibitors for the treatment of cancer
EP4334324A1 (en) 2021-05-05 2024-03-13 Revolution Medicines, Inc. Covalent ras inhibitors and uses thereof
AR127308A1 (en) 2021-10-08 2024-01-10 Revolution Medicines Inc RAS INHIBITORS
WO2023114954A1 (en) 2021-12-17 2023-06-22 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
EP4227307A1 (en) 2022-02-11 2023-08-16 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
WO2023172940A1 (en) 2022-03-08 2023-09-14 Revolution Medicines, Inc. Methods for treating immune refractory lung cancer
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2024081916A1 (en) 2022-10-14 2024-04-18 Black Diamond Therapeutics, Inc. Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE666541A (en) * 1964-07-08
GB1495189A (en) * 1975-09-12 1977-12-14 Pfizer Ltd 4-oxo-4h-benzopyran derivatives and process for their preparation
FR2693724B1 (en) * 1992-07-17 1994-10-07 Lipha Use of benzopyran or benzothiopyran compounds for the induction of the expression of genes for the nodulation of bacteria of the genus Rhizobium associated with legumes.
EP0674530B1 (en) * 1992-12-21 2004-09-01 Mallinckrodt Inc. Radiolabeled polyhydric phenol compounds
WO1996035683A1 (en) * 1995-05-09 1996-11-14 Nippon Kayaku Kabushiki Kaisha Novel physiologically active na23063 analogues, process for producing the same and use of the same

Also Published As

Publication number Publication date
GB9621757D0 (en) 1996-12-11
WO1998017662A1 (en) 1998-04-30

Similar Documents

Publication Publication Date Title
AU4947997A (en) Phenyl-substituted bicyclic heterocyclyl derivatives and their use
AU5752398A (en) Novel ketobenzamides and their use
AU1363397A (en) Vision system and proximity detector
AU5840396A (en) N-heteroaryl-pyridinesulfonamide derivatives and their use as endothelin antagonists
AU2339697A (en) Alpha-branched fluoroalkylcarbonyl fluorides and their derivatives
AU3753597A (en) Incisor-dilator with tapered balloon
AU4997397A (en) Card-recognition and gaming-control device
AU1315797A (en) Piperazinonephenyloxazolidinone derivatives and their use as antibacterial agents
AU3102097A (en) Spiro-piperidine derivatives and their use as therapeutic agents
AU2769697A (en) Benzofuryl derivatives and their use
AU1886197A (en) Quinolones and their therapeutic use
AU2655097A (en) Aminoisoquinolines and aminothienopyridine derivatives and their use as anti-inflammatory agents
AU4266596A (en) Composition and use
AU4479997A (en) Sustained delivery device and methods of making and using the same
AU4204697A (en) Tetrahydroisoquinoline derivatives and their pharmaceutical use
AU4556797A (en) Substituted phthalocyanines and their use
AU2464197A (en) Triazine derivatives and their use
AU5383498A (en) Human chemokine beta-13
AU5923998A (en) 2-benzoylamino-3-phenylpropenamide derivatives and methods of using the same
AU3268197A (en) Spiro-piperidine derivatives and their use as therapeutic agents
AU3118297A (en) Sok-1 and methods of use
AU3634595A (en) Bis-oxazolidines and their use
AU3116697A (en) Human interleukin-1j and antagonists thereof
AU2405397A (en) Thienopyridine derivatives and their use
AU1846397A (en) Prolactin antagonists and uses thereof