AU4858796A - Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in treatment of various disorders - Google Patents

Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in treatment of various disorders

Info

Publication number
AU4858796A
AU4858796A AU48587/96A AU4858796A AU4858796A AU 4858796 A AU4858796 A AU 4858796A AU 48587/96 A AU48587/96 A AU 48587/96A AU 4858796 A AU4858796 A AU 4858796A AU 4858796 A AU4858796 A AU 4858796A
Authority
AU
Australia
Prior art keywords
acid
phenylalkenoic
phenylalkanoic
ethyl esters
triglycerides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU48587/96A
Inventor
Saul W. Brusilow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23519346&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU4858796(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of AU4858796A publication Critical patent/AU4858796A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C07C69/618—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Two new forms of prodrug for phenylacetate, of even congeners of phenylalkanoic acid and phenylalkenoic acids, which are the phenylalkanoic or phenylalkenoic esters of glycerol, or the ethyl esters of phenylalkanoic acid or phenylalkenoic acids. These forms of the drugs provide a convenient dosage form of the drugs. The prodrugs of the invention are useful to treat patients with diseases of nitrogen accumulation, patients with certain beta -hemoglobinopathies, anemia, and cancer.
AU48587/96A 1995-02-07 1996-02-06 Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in treatment of various disorders Abandoned AU4858796A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US384935 1982-06-04
US38493595A 1995-02-07 1995-02-07
PCT/US1996/000940 WO1996024571A1 (en) 1995-02-07 1996-02-06 Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in treatment of various disorders

Publications (1)

Publication Number Publication Date
AU4858796A true AU4858796A (en) 1996-08-27

Family

ID=23519346

Family Applications (1)

Application Number Title Priority Date Filing Date
AU48587/96A Abandoned AU4858796A (en) 1995-02-07 1996-02-06 Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in treatment of various disorders

Country Status (9)

Country Link
US (3) US5968979A (en)
EP (1) EP0858441B1 (en)
AT (1) ATE201013T1 (en)
AU (1) AU4858796A (en)
CA (1) CA2212047C (en)
DE (1) DE69612755T2 (en)
ES (1) ES2157422T3 (en)
FR (1) FR16C0003I2 (en)
WO (1) WO1996024571A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6642543B1 (en) 2000-09-26 2003-11-04 The Board Of Trustees Of The Leland Stanford Junior University Thin and thick gate oxide transistors on a functional block of a CMOS circuit residing within the core of an IC chip
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7057057B2 (en) 2002-05-22 2006-06-06 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
US7842727B2 (en) 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US6495719B2 (en) 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US20040229948A1 (en) * 2002-04-12 2004-11-18 Summar Marshall L. Method for preventing hepatic encephalopathic episodes
US20030195255A1 (en) * 2002-04-12 2003-10-16 Summar Marshall L. Method for treating hepatic encephalopathies
JP2006508986A (en) 2002-11-20 2006-03-16 エルラント ゲネ セラペウチクス エルエルシー Treatment of lung cells with histone deacetylase inhibitors
US20090260743A1 (en) * 2003-11-21 2009-10-22 William David Mawby Tire manufacturing method for improving the uniformity of a tire
US20060160902A1 (en) * 2004-11-08 2006-07-20 Wiech Norbert L Histone deacetylase inhibitors
EP3133396B1 (en) * 2008-04-29 2018-09-05 Horizon Therapeutics, LLC Methods of treatment using ammonia-scavenging drugs
ES2593378T3 (en) * 2008-08-29 2016-12-09 Horizon Therapeutics, Llc Methods of treatment using ammonia sequestration drugs
US8404215B1 (en) 2011-09-30 2013-03-26 Hyperion Therapeutics, Inc. Methods of therapeutic monitoring of nitrogen scavenging
DK2846791T3 (en) 2012-04-20 2017-03-27 Horizon Therapeutics Llc HPN-100 FOR USE IN TREATMENT OF NITROGEN RETENTION DISORDER
ES2654774T3 (en) 2012-11-21 2018-02-15 Horizon Therapeutics, Llc Methods for administering and evaluating nitrogen recovery drugs for the treatment of hepatic encephalopathy
HUE045106T2 (en) 2013-10-14 2019-12-30 Immedica Pharma Ab Methods of treating urea cycle disorders
IN2013MU03442A (en) 2013-10-30 2015-07-17 Lupin Ltd
KR102291310B1 (en) 2013-11-14 2021-08-23 울트라제닉스 파마수티컬 인코포레이티드 Solid compositions of triglycerides and uses thereof
EP3137116B1 (en) 2014-04-30 2020-12-16 The Johns Hopkins University Dendrimer compositions and their use in treatment of diseases of the eye
CA2957721C (en) 2014-08-13 2021-04-13 The Johns Hopkins University Selective dendrimer delivery to brain tumors
CN108430514B (en) 2015-10-29 2023-11-03 约翰霍普金斯大学 Compositions and methods for treating peroxisome disorders and leukodystrophies
US9914692B2 (en) 2016-05-25 2018-03-13 Horizon Therapeutics, Llc Procedure for the preparation of 4-phenyl butyrate and uses thereof
US10668040B2 (en) 2017-09-11 2020-06-02 Horizon Therapeutics, Llc Treatment of urea cycle disorders in neonates and infants
WO2021113662A2 (en) 2019-12-04 2021-06-10 Ashvattha Therapeutics, Inc. Dendrimer compositions and methods for drug delivery to the eye

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders

Also Published As

Publication number Publication date
ATE201013T1 (en) 2001-05-15
US6083984A (en) 2000-07-04
US6060510A (en) 2000-05-09
EP0858441B1 (en) 2001-05-09
FR16C0003I2 (en) 2016-06-24
WO1996024571A1 (en) 1996-08-15
DE69612755D1 (en) 2001-06-13
CA2212047C (en) 2010-11-16
EP0858441A1 (en) 1998-08-19
EP0858441A4 (en) 1998-08-19
CA2212047A1 (en) 1996-08-15
FR16C0003I1 (en) 2016-03-25
DE69612755T2 (en) 2001-08-23
US5968979A (en) 1999-10-19
ES2157422T3 (en) 2001-08-16

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