AU469908B2 - Prostaglandin analogs - Google Patents

Prostaglandin analogs

Info

Publication number
AU469908B2
AU469908B2 AU59430/73A AU5943073A AU469908B2 AU 469908 B2 AU469908 B2 AU 469908B2 AU 59430/73 A AU59430/73 A AU 59430/73A AU 5943073 A AU5943073 A AU 5943073A AU 469908 B2 AU469908 B2 AU 469908B2
Authority
AU
Australia
Prior art keywords
prostaglandin analogs
prostaglandin
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU59430/73A
Other languages
English (en)
Other versions
AU5943073A (en
Inventor
Warren Yankee Ernest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AU5943073A publication Critical patent/AU5943073A/en
Application granted granted Critical
Publication of AU469908B2 publication Critical patent/AU469908B2/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/38Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0834Compounds having one or more O-Si linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4018Esters of cycloaliphatic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056Esters of arylalkanephosphonic acids
    • C07F9/4059Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • C07F9/5407Acyclic saturated phosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU59430/73A 1972-09-15 1973-08-21 Prostaglandin analogs Expired AU469908B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28931772A 1972-09-15 1972-09-15
USUS289317 1972-09-15
US05/374,405 US4100355A (en) 1972-09-15 1973-06-28 8β,12α-PGE2 -type compounds
US51854974A 1974-10-29 1974-10-29
US51869574A 1974-10-29 1974-10-29

Publications (2)

Publication Number Publication Date
AU5943073A AU5943073A (en) 1975-03-13
AU469908B2 true AU469908B2 (en) 1976-02-26

Family

ID=27501499

Family Applications (1)

Application Number Title Priority Date Filing Date
AU59430/73A Expired AU469908B2 (en) 1972-09-15 1973-08-21 Prostaglandin analogs

Country Status (9)

Country Link
US (3) US4100355A (US07488766-20090210-C00029.png)
AU (1) AU469908B2 (US07488766-20090210-C00029.png)
BE (1) BE804873A (US07488766-20090210-C00029.png)
CA (1) CA1047491A (US07488766-20090210-C00029.png)
CH (2) CH593961A5 (US07488766-20090210-C00029.png)
DE (1) DE2345695A1 (US07488766-20090210-C00029.png)
FR (1) FR2199983B1 (US07488766-20090210-C00029.png)
GB (2) GB1449146A (US07488766-20090210-C00029.png)
NL (1) NL7312685A (US07488766-20090210-C00029.png)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792803A (fr) * 1971-12-17 1973-03-30 Erba Carlo Spa Derives d'acide 8,12-diisoprostanoique optiquement actifs, leurpreparation et compositions en contenant
MX3291E (es) * 1975-04-23 1980-08-22 Upjohn Co Procedimiento para preparar analogos de prostaglandinas
US4955878A (en) * 1986-04-04 1990-09-11 Biotechnology, Inc. Kit for preventing or treating arterial dysfunction resulting from angioplasty procedures
US5190972A (en) * 1992-01-27 1993-03-02 The University Of Melbourne Method of combatting cyclosporine organ toxicity with prostaglandin analogs
GB0112699D0 (en) 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2119855A1 (en) * 1970-12-29 1972-08-11 Roussel Uclaf Synthesis of prostaglandins - without loss of stereospecificity
CA963900A (en) * 1971-05-04 1975-03-04 Frank H. Lincoln (Jr.) Prostaglandin-type compounds
US3862984A (en) * 1971-07-02 1975-01-28 Upjohn Co 15-oxo,11{62 pgf{hd 2{b {301 and {331

Also Published As

Publication number Publication date
FR2199983B1 (US07488766-20090210-C00029.png) 1977-11-10
CH593961A5 (US07488766-20090210-C00029.png) 1977-12-30
BE804873A (fr) 1974-03-14
GB1449147A (en) 1976-09-15
AU5943073A (en) 1975-03-13
NL7312685A (US07488766-20090210-C00029.png) 1974-03-19
US4100355A (en) 1978-07-11
GB1449146A (en) 1976-09-15
US4095036A (en) 1978-06-13
FR2199983A1 (US07488766-20090210-C00029.png) 1974-04-19
CH605731A5 (US07488766-20090210-C00029.png) 1978-10-13
US4084063A (en) 1978-04-11
CA1047491A (en) 1979-01-30
DE2345695A1 (de) 1974-03-28

Similar Documents

Publication Publication Date Title
ZA742575B (en) Prostaglandin analogs
CA1026329A (en) Prostaglandin analogues
PH13325A (en) Prostaglandin intermediates
ZA742574B (en) Prostaglandin analogs
AU474893B2 (en) New prostaglandin type sulphides
ZA732244B (en) Prostaglandin analogs
AU473283B2 (en) 8,12 prostaglandin analogues
AU469908B2 (en) Prostaglandin analogs
ZA732352B (en) Prostaglandin analogs
HK75276A (en) Difluoromethylene substituted prostaglandin derivatives
AU6322173A (en) Prostaglandin compositions
ZA744580B (en) Prostaglandin analogs
AU7020474A (en) Prostaglandin analogues
ZA737328B (en) Prostaglandin compounds
CA950901A (en) Prostaglandin a compounds
CA978940A (en) Prostaglandin derivatives
AU479440B2 (en) Prostaglandin analogues
GB1540427A (en) Prostaglandin analogues
AU6055473A (en) Prostaglandin analogues
ZA735739B (en) Prostaglandin analogs
AU459678B2 (en) Prostaglandin analogues
CA973177A (en) Prostaglandin derivatives
AU478207B2 (en) Difluoromethylene substituted prostaglandin derivatives
CA892617A (en) Prostaglandin intermediates
CA822134A (en) Prostaglandin analogs