AU4646893A - Thiobenzoylation method of peptide sequencing with gas chromatography and mass spectrometric detection - Google Patents

Thiobenzoylation method of peptide sequencing with gas chromatography and mass spectrometric detection

Info

Publication number
AU4646893A
AU4646893A AU46468/93A AU4646893A AU4646893A AU 4646893 A AU4646893 A AU 4646893A AU 46468/93 A AU46468/93 A AU 46468/93A AU 4646893 A AU4646893 A AU 4646893A AU 4646893 A AU4646893 A AU 4646893A
Authority
AU
Australia
Prior art keywords
thiobenzoylation
gas chromatography
mass spectrometric
spectrometric detection
peptide sequencing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU46468/93A
Inventor
Mark L. Stolowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of AU4646893A publication Critical patent/AU4646893A/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/128—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G01N33/6824—Sequencing of polypeptides involving N-terminal degradation, e.g. Edman degradation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/141111—Diverse hetero atoms in same or different rings [e.g., alkaloids, opiates, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU46468/93A 1992-07-24 1993-06-17 Thiobenzoylation method of peptide sequencing with gas chromatography and mass spectrometric detection Abandoned AU4646893A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/919,524 US5246865A (en) 1992-07-24 1992-07-24 Thiobenzoylation method of peptide sequencing with gas chromatography and mass spectrometric detection
PCT/US1993/005992 WO1994002844A1 (en) 1992-07-24 1993-06-17 Thiobenzoylation method of peptide sequencing with gas chromatography and mass spectrometric detection
US919524 2004-08-17

Publications (1)

Publication Number Publication Date
AU4646893A true AU4646893A (en) 1994-02-14

Family

ID=25442245

Family Applications (1)

Application Number Title Priority Date Filing Date
AU46468/93A Abandoned AU4646893A (en) 1992-07-24 1993-06-17 Thiobenzoylation method of peptide sequencing with gas chromatography and mass spectrometric detection

Country Status (3)

Country Link
US (1) US5246865A (en)
AU (1) AU4646893A (en)
WO (1) WO1994002844A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US6436635B1 (en) 1992-11-06 2002-08-20 Boston University Solid phase sequencing of double-stranded nucleic acids
JP3015468B2 (en) * 1994-07-08 2000-03-06 シティ・オブ・ホープ N-terminal protein sequencing reagent and method for producing amino acid derivative
US7803529B1 (en) 1995-04-11 2010-09-28 Sequenom, Inc. Solid phase sequencing of biopolymers
JP3124507B2 (en) * 1996-05-24 2001-01-15 セイコーインスツルメンツ株式会社 Method for determining amino acid sequence from carboxy terminus of protein or peptide
US5885841A (en) * 1996-09-11 1999-03-23 Eli Lilly And Company System and methods for qualitatively and quantitatively comparing complex admixtures using single ion chromatograms derived from spectroscopic analysis of such admixtures
GB9710582D0 (en) 1997-05-22 1997-07-16 Oxford Glycosciences Uk Ltd A method for de novo peptide sequence determination
US5824556A (en) * 1997-06-11 1998-10-20 Tarr; George E. Peptide mass ladders generated using carbon disulfide
US6963807B2 (en) 2000-09-08 2005-11-08 Oxford Glycosciences (Uk) Ltd. Automated identification of peptides
US20080076680A1 (en) * 2006-04-13 2008-03-27 Ozone Research Frontier Ltd. System and apparatus for automated protein analysis priority
WO2010099108A2 (en) * 2009-02-24 2010-09-02 Mayo Foundation For Medical Education And Research Multiplexing derivatized anayltes using mass spectroscopy
AU2014218193B2 (en) 2013-02-12 2018-02-08 Sectago Gmbh Security device
US10207531B2 (en) 2013-12-02 2019-02-19 SECTAG GmbH Security device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997298A (en) * 1975-02-27 1976-12-14 Cornell Research Foundation, Inc. Liquid chromatography-mass spectrometry system and method
US4224031A (en) * 1977-11-15 1980-09-23 Mee John M L CI Mass spectrometric analysis of physiologically active compounds
US4548904A (en) * 1982-12-03 1985-10-22 Molecular Genetics Research & Development Protein sequencing method
US4863870A (en) * 1988-03-10 1989-09-05 Bio-Affinity Systems, Inc. Method of thioacylation peptide sequencing with alcoholysis of thiazolinones
US4861726A (en) * 1988-03-10 1989-08-29 Bio-Affinity Systems, Inc. Method of thioacylation peptide sequencing with acylation of thiazoloinones
US5008372A (en) * 1990-02-12 1991-04-16 Cornell Research Foundation, Inc. Deblocking amino terminal N-acetyl serine and N-acetyl threonine residues in peptides and proteins to allow sequencing

Also Published As

Publication number Publication date
US5246865A (en) 1993-09-21
WO1994002844A1 (en) 1994-02-03

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