AU4152193A - Anti-DCC gene product specific monoclonal antibody - Google Patents

Anti-DCC gene product specific monoclonal antibody

Info

Publication number
AU4152193A
AU4152193A AU41521/93A AU4152193A AU4152193A AU 4152193 A AU4152193 A AU 4152193A AU 41521/93 A AU41521/93 A AU 41521/93A AU 4152193 A AU4152193 A AU 4152193A AU 4152193 A AU4152193 A AU 4152193A
Authority
AU
Australia
Prior art keywords
monoclonal antibody
dcc
dcc gene
gene product
specific monoclonal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU41521/93A
Other versions
AU675067B2 (en
Inventor
Shozo Baba
Nobuo Hanai
Tadachika Ozawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of AU4152193A publication Critical patent/AU4152193A/en
Application granted granted Critical
Publication of AU675067B2 publication Critical patent/AU675067B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y10S436/813—Cancer

Abstract

This invention relates to monoclonal antibodies capable of specifically reacting with a peptide encoded by tumor suppressor gene DCC gene and to hybridomas capable of producing such monoclonal antibodies. In particular, the invention relates to mouse monoclonal antibody KM890 belonging to the IgG3 subclass, which is specifically reactive with a DCC gene DCC-2, and to a hybridoma KM890 capable of producing the monoclonal antibody KM890. The monoclonal antibodies of this invention which are specifically reactive with DCC gene products can be used in immunohistochemical staining, quantitative determination of DCC gene products and the like, as well as in cancer diagnosis.
AU41521/93A 1992-06-25 1993-06-25 Anti-DCC gene product specific monoclonal antibody Ceased AU675067B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4-167101 1992-06-25
JP16710192A JP3151054B2 (en) 1992-06-25 1992-06-25 Anti-DCC gene product monoclonal antibody

Publications (2)

Publication Number Publication Date
AU4152193A true AU4152193A (en) 1994-01-06
AU675067B2 AU675067B2 (en) 1997-01-23

Family

ID=15843450

Family Applications (1)

Application Number Title Priority Date Filing Date
AU41521/93A Ceased AU675067B2 (en) 1992-06-25 1993-06-25 Anti-DCC gene product specific monoclonal antibody

Country Status (7)

Country Link
US (1) US5445938A (en)
EP (1) EP0577028B1 (en)
JP (1) JP3151054B2 (en)
AT (1) ATE201881T1 (en)
AU (1) AU675067B2 (en)
CA (1) CA2099628A1 (en)
DE (1) DE69330297T2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009964A1 (en) * 1990-01-04 1991-07-11 The Johns Hopkins University Gene deleted in colorectal cancer of humans
WO1994028161A1 (en) * 1993-05-26 1994-12-08 The Johns Hopkins University Antibodies specific for dcc gene product
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US7935675B1 (en) * 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6818787B2 (en) * 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ207394A (en) * 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
JPH03505675A (en) * 1988-10-31 1991-12-12 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア Producers and methods for controlling suppression of neoplastic phenotypes
CA2065874C (en) * 1989-09-15 2001-12-11 Joseph P. Brown Hybridoma ct43 producing a monoclonal antibody to a mucin epitope of colorectal cancer
WO1991009964A1 (en) * 1990-01-04 1991-07-11 The Johns Hopkins University Gene deleted in colorectal cancer of humans

Also Published As

Publication number Publication date
EP0577028A2 (en) 1994-01-05
JPH067192A (en) 1994-01-18
JP3151054B2 (en) 2001-04-03
CA2099628A1 (en) 1993-12-26
EP0577028A3 (en) 1994-11-02
AU675067B2 (en) 1997-01-23
DE69330297T2 (en) 2002-05-02
EP0577028B1 (en) 2001-06-06
US5445938A (en) 1995-08-29
ATE201881T1 (en) 2001-06-15
DE69330297D1 (en) 2001-07-12

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired