AU3918899A - Methods and compositions for treatment of restenosis and cancer using ribozymes - Google Patents

Description

DESCRIPTION

Methods and Compositions for Treatment of Restenosis and Cancer Using Ribozymes Background Of The Invention The present invention concerns therapeutic compositions and methods for the treatment of restenosis and cancer.

5 The following is a brief description of the physiology, cellular pathology and treatment of restenosis.

The discussion is not meant to be complete and is provided only for understanding of the invention that follows.

This summary is not an admission that any of the work described below is prior art to the claimed invention.

Coronary angioplasty is one of the major surgical treatments for heart disease. Its use has been accelerating rapidly; over 450,000 procedures are performed in the U.S. annually. The short term success rate of angioplasty 15 is 80 to 90%. However, in spite of a number of technical improvements in the procedure, post-operative occlusions of the arteries, or restenosis, still occur. Thirty-five to forty-five percent of patients who have undergone a single vessel angioplasty develop clinically significant restenosis within 6 months of the procedure. The rate of restenosis is even higher (50 to 60%) in patients who have undergone multivessel angioplasty (Califf, R. et al., 1990, in Textbook of Interventional Cardiolovy., E.J.

Topol, ed., W. B. Saunders, Philadelphia, pp 363-394.).

Histopathological studies have shown that restenosis after angioplasty is characterized by migration of medial smooth muscle cells to the intima and a striking hyperproliferative response of these neointimal cells (Garratt, K. et al., 1991, J. Am. Coll. Cardio., 17, 442-428; Austin, G. et al., 1985, J Am. Coll. Cardiol., 6, 369-375). Smooth muscle cell proliferation could be an overly robust response to injury. Alternatively, the intimal smooth muscle cells within atherosclerotic lesions are already in an activated or "synthetic" state (Sjolund, et al., 1988, J. Cell. Biol., 106, 403-413 and thus may be poised to proliferate. One recent study demonstrated a positive correlation between the presence of activated smooth muscle cells in coronary lesions and the extent of subsequent luminal narrowing after atherectomy (Simons, et al., 1993, New Enrl. J. Med., 328, 608- 613). In any case, slowing smooth muscle cell prolifera- 10 tion after angioplasty could prevent intimal thickening and restenosis.

The presently preferred therapeutic treatment for restenosis is the use of streptokinase, urokinase or other thrombolytic compounds, such as fish oil, anticoagulants, ACE (angiotensin converting enzyme) inhibitors, aspirin and cholesterol lowering compounds. Alternative treatment includes the surgical incorporation of endoluminal stents.

The occurrence of pharmacologic side-effects (particularly bleeding disorders associated with anti-coagulants and 20 platelet inhibitors) is an issue with current therapies.

Popoma, J. et al., report that the current tnerapies have not significantly impacted the rates of restenosis occurrence. (Circulation, 84, 1426-1436, 1991) Recently, :he results of a clinical trial of the efficacy of an anti-platelet therapy have been reported.

Patients undergoing coronary angioplasty were given a single bolus injection followed by a 12 hour infusion of an antibody directed against the platelet adhesion molecule, gpIIb/gpIIIa. After six months, patients with the treatment showed a 23% reduction in the occurrence of restenosis than patients receiving placebo (27 vs. p=0.001).

A number of growth factors have been shown to induce smooth muscle cell proliferation. In vitro, plateletderived growth factor (PDGF) is a potent smooth muscle cell mitogen (Ross, et al., 1974, Proc. Natl. Acad.

Sci. USA, 71, 1207-1210) and a smooth muscle cell chemoattractant (Grotendorst, et al., 1982, Proc. Natl.

Acad. Sci. USA, 71, 3669-3672.). In vivo, when PDGF is expressed ectopically in porcine arteries, it induces intimal hyperplasia (Nabel, E. et al., 1993, J. Clin Invest., 91, 1822-1829). Furthermore, antibodies to PDGF have been shown to reduce intimal thickening after arterial injury (Ferns, G. A. et al., 1991, Science, 253, 1129-1132). Analysis of 3 H-thymidine incorporation in the lesions indicates that the anti-PDGF antibodies primarily inhibit smooth muscle cell migration.

Basic fibroblast growth factor (bFGF) is another smooth muscle cell mitogen in vitro (Klagsbrun, M. and Edelman, E. 1989, Arteriosclerosis, 9, 269-278) In a rat model, anti-bFGF antibodies inhibit the proliferation of medial smooth muscle cells 24 to 48 hours after balloon catheter injury (Lidner, V. and Reidy, M. A., 1991, Proc. Natl. Acad. Sci. USA, 88, 3739-3743). In addition to bFGF, heparin binding epidermal growth factor (HB-EGF) (Higashiyama, et al., 1991, Science, 251, 20 936-939.), insulin-like growth factor I (IGF-I) (Banskota, N. et al., 1989, Molec. Endocrinol., 3, 1183-1190) and endothelin (Komuro, et al., 1988, FEBS Letters, 238, 249-252) have been shown to induce smooth muscle cell proliferation. A number of other factors (such as interleukin-1 and tumor necrosis factor-a) may indirectly affect smooth muscle cell proliferation by inducing the expression of PDGF (Hajjar, K. et al., 1987, J. Exp.

Med., 166, 235-245; Raines, E. et al., 1989, Science, 243, 393-396).

When whole serum is added to serum-starved smooth muscle cells in vitro, the oncogenes, c-myc, c-fos, and cmyb, are induced (Kindy, M. S. and Sonenshein, G. E., 1986, J. Biol. Chem., 261, 12865-12868; Brown, K. et al., 1992, J. Biol. Chem., 267, 4625-4630) and cell proliferation ensues. Blocking c-myb with an antisense oligonucleotide prevents cells from entering S phase (Brown, K. et al., 1992, J. Biol. Chem., 267, 4625- 4630.). Thus, c-myb is required for the G 1 to S transition after stimulation by the multitude of growth factors present in serum. In vivo, a c-myb antisense oligonucleotide inhibits restenosis when applied to rat arteries after balloon angioplasty (Simons, et al., 1992, Nature, 359, 67-70). Similarly, an antisense oligonucleotide directed against mRNA of the oncogene c-myc was shown to inhibit human smooth muscle cell proliferation (Shi, et al., 1993, Circulation, 88, 1190-5) and migration 10 (Biro, et al., 1993, Proc. Natl. Acad. Sci. U S A, 654-8).

Ohno et al., 1994 Science 265, 781, have shown that a combination of viral thymidine kinase enzyme expression gene erapy d tr atment with anti-viral drug ganciclovir inhibits smoot: muscle cell proliferation in pigs, following baloon angioplasty.

Epstein et al., "Inhibition of non-transformed cell proliferation using antisense oligonucleotides,"

NTIS

publication 19:- discusses use of antisense oligonucleo- 20 to c-my-: PCNA or cyclin B. <ing et al., PCT W091/15580, describes gene therapy for cell proliferative ''disease and mentions administration of a ribozyme construct against a PGR element. Mention is made of inactivation of c-myb. Rosenberg et al., W093/08845, Calabretta et al., W092/20348 and Gewirtz W093/09789 concern c-myb antisense oligonucleotides for treatment of melanoma or colorectal cancer, and administration locally. Sytkowski, PCT WO 93/02654, describe the uses of antisense oligonucleotides to inhibit c-myb gene expression in red blood cells to stimulate hemoglobin synthesis.

Nabel and Nabel, U. S. Patent No. 5, 328, 470, describe a method for the treatment of diseases by delivering therapeutic reagents directly to the sites of disease. They state that- Method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems... In addition, catalytic RNAs, called ribozymes, can specifically degrade RNA sequences.... The requirements for a successful RNA cleavage include a hammerhead structure with conserved RNA sequence at the region flanking this structure..... any GUG sequence within the RNA transcript can serve as a target for degradation by the ribozyme....

gene transfer using vectors expressing such proteins as tPA for the treatment of thrombosis and restenosis, angiogenesis or growth factors for the purpose of revascularization...

Sullivan and Draper, International PCT publication WO 94/02595 describe the use of ribozymes against c-myb RNA 15 to treat stenosis.

Summary Of The Invention This invention relates to ribozymes, or enzymatic RNA molecules, directed to cleave mRNA species that are 20 required for cellular growth responses. In particular, applicant describes the selection and function of ribozymes capable of cleaving RNA encoded by the oncogene, cmyb. Such ribozymes may be used to inhibit the hyperproliferation of smooth muscle cells in restenosis and of tumor cells in numerous cancers. To block restenosis, a target molecule required for the induction of smooth muscle cell proliferation by a number of different growth factors is preferred. To this end c-myc, c-fos, and c-myb are useful targets in this invention.

Other transcription factors involved in the response to growth and proliferation signals include NF-KB, oct-i and SRF. NF-KB protein activates cellular transcription and induces increases in cellular synthetic pathways. In a resting cell, this protein is found in the cytoplasm, complexed with its inhibitor, I-KB. Upon phosphorylation of the I-KB molecule, the complex dissociates and NF-KB is released for transport to the nucleus, where it binds DNA and induces transcriptional activity in (NF-KB)-responsive genes. One of the (NF-KB)-responsive genes is the NF-KB gene itself. Thus, release of the NF-KB protein from the inhibitory complex results in a cascade of gene expression which is auto-induced. Early inhibition of NF-KB can reduce expression of a number of genes required for growth and proliferation, such as c-myb.

Two other transcription factors, oct-i and serum response factor (SRF) have been shown to be expressed selectively in dividing cells. Both oct-i and SRF are expressed ubiquitously in cultured cells, including smooth muscle cells. However, R. Majack and his colleagues have recently shown that these transcription factors are not expressed by the smooth muscle cells in intact vessels.

15 Both oct-1 and SRF are rapidly expressed upon dispersal of tissue into single cell suspensions. Thus, these transcription factors are thought to be regulated by their interactions with the extracellular matrix (Weiser, M. C.

et al., 1994, J. Cell. Biochem., S18A, 282; Belknap, 20 J. et al., 1994, J. Cell. Biochem., S18A, 277). Upon injury during angioplasty, the expression of oct-1 and SRF may be enhanced, leading to increased smooth muscle cell proliferation. Treatment with ribozymes that block the expression of these transcription factors can alleviate the smooth muscle cell proliferation associated with restenosis.

While some of the above mentioned studies demonstrated that antisense oligonucleotides can efficiently reduce the expression of factors required for smooth muscle cell proliferation, enzymatic RNAs, or ribozymes have yet to be demonstrated to inhibit smooth muscle cell proliferation. Such ribozymes, with their catalytic activity and increased site specificity (as described below), represent more potent and safe therapeutic molecules than antisense oligonucleotides. In the present invention, ribozymes that cleave c-myb mRNA are described.

Moreover, applicant shows that these ribozymes are able to 7 inhibit smooth muscle cell proliferation and that the catalytic activity of the ribozymes is required for their inhibitory effect. From those of ordinary skill in the art, it is clear from the examples described, that other ribozymes that cleave target mRNAs required for smooth muscle cell proliferation may be readily designed and are within the invention.

By "inhibit" is meant that the activity of c-myb or level of mRNAs encoded by c-myb is reduced below that observed in the absence of the nucleic acid, particularly, inhibition with ribozymes and preferably is below that level observed in the presence of an inactive RNA molecule able to bind to the same site on the mRNA, but unable to cleave that RNA.

15 By "enzymatic nucleic acid molecule" it is meant a nucleic acid molecule which has complementarity in a substrate binding region to a specified gene target, and also has an enzymatic activity which is active to specifically cleave RNA in that target. That is, the enzymatic nucleic acid molecule is able to intermolecularly cleave RNA and thereby inactivate a target RNA molecule. This complementarity functions to allow sufficient hybridization of the S* enzymatic nucleic acid molecule to the target RNA to allow the cleavage to occur. One hundred percent complementarity is preferred, but complementarity as low as 50-75% may also be useful in this invention. By "equivalent" RNA to c-myb is meant to include those naturally occurring RNA molecules associated with restenosis and cancer in various animals, including human, rat and pig. Such a molecule will generally contain some ribonucleotides, but the other nucleotides may be substituted at the 2'-hydroxyl position and in other locations with other moeities as discussed below.

By "complementarity" is meant a nucleic acid that can form hydrogen bond(s) with other RNA sequence by either traditional Watson-Crick or other non-traditional. types (for example, Hoogsteen type) of base-paired interactions.

Six basic varieties of naturally-occurring enzymatic RNAs are known presently. Each can catalyze the hydrolysis of RNA phosphodiester bonds in trans (and thus can cleave other RNA molecules under physiological conditions.

Table I summarizes s: e of the characteristics of these ribozymes. In gener&-, enzymatic nucleic acids act by first binding to a target RNA. Such oinding occurs through the target binding portion of a enzymatic nucleic acid which is held in close proximity to an enzymatic portion of the molecule that acts to cleave the target RNA. Thus, the enzymatic nucleic acid first recognizes and then binds a target RNA through complementary basepairing, and once bound to the correct site, acts enzymatically to cut the target RNA. Strategic cleavage 15 of such a target RNA will destroy its ability to direct synthesis of an encoded protein. After an enzymatic nucleic acid has bound and cleaved its RNA target, it is released from that RNA to search for another target and can repeatedly bind and cleave new targets.

20 The enzymatic nature of a ribozyme is advantageous "over other technologies, such as antisense technology (where a nucleic acid molecule simply binds to a nucleic S. I* acid target to block its translation) since the concentra- •tion of ribozyme necessary to affect a therapeutic treatment is lower than that of an antisense oligonucleotide.

This advantage reflects the ability of the ribozyme to act enzymatically. Thus, a single ribozyme molecule is able to cleave many molecules of target RNA. In addition, the ribozyme is a highly specific inhibitor, with the specificity of inhibition depending not only on the base pairing mechanism of binding to the target RNA, but also on the mechanism of target RNA cleavage. Single mismatches, or base-substitutions, near the site of cleavage can completely eliminate catalytic activity of a ribozyme.

Similar mismatches in antisense molecules do not prevent their action (Woolf, T. et al., 1992, Proc. Natl.

Acad. Sci. USA, 89, 7305-7309). Thus, the specificity of action of a ribozyme is greater than that of an antisense oligonucleotide binding the same RNA site.

In preferred embodiments of this invention, the enzymatic nucleic acid molecule is formed in a hammerhead or hairpin motif, but may also be formed in the motif of a hepatitis delta virus, group I intron or RNaseP RNA (in association with an RNA guide sequence) or Neurospora VS RNA. Examples of such hammerhead motifs are described by Rossi et al., 1992, Aids Research and Human Retroviruses 8, 183, of hairpin motifs by Hampel et al., EP0360257, Hampel and Tritz, 1989 Biochemistry 28, 4929, and Hampel et al., 1990 Nucleic Acids Res. 18, 299, and an example of the hepatitis delta virus motif is described by Perrotta and Been, 1992 Biochemistry 31, 16; of the RNaseP motif by 15 Guerrier-Takada et al., 1983 Cell 35, 849, Neurospora VS RNA ribozyme motif is described by Collins (Saville and Collins, 1990 Cell 61, 685-696; Saville and Collins, 1991 Proc. Natl. Acad. Sci. USA 88, 8826-8830; Collins and Olive, 1993 Biochemistry 32, 2795-2799) and of the Group 20 I intron by Cech et al., U.S. Patent 4,987,071. These specific motifs are not limiting in the invention and those skilled in the art will recognize that all that is important in an enzymatic nucleic acid molecule of this invention is that it has a specific substrate binding site which is complementary to one or more of the target gene RNA regions, and that it have nucleotide sequences within or surrounding that substrate binding site which impart an RNA cleaving activity to the molecule.

In a preferred embodiment the invention provides a method for producing a class of enzymatic cleaving agents which exhibit a high degree of specificity for the RNA of a desired target. The enzymatic nucleic acid molecule is preferably targeted to a highly conserved sequence region of a target mRNAs encoding c-myb proteins such that specific treatment of a disease or condition can be provided with either one or several enzymatic nucleic acids.

Such enzymatic nucleic acid molecules can be delivered exogenously to specific cells as required. Alternatively, the ribozymes can be expressed from DNA/RNA vectors that are delivered to specific cells.

Synthesis of nucleic acids greater :han 100 nucleotides in length is difficult using automated methods, and the therapeutic cost of such molecules is prohibitive. In this invention, small enzymatic nucleic acid motifs of the hammerhead or the hairpin structure) are used for exogenous delivery. The simple structure of these molecules increases the ability of the enzymatic nucleic acid to invade targeted regions of the mRNA structure.

However, these catalytic RNA molecules can also be expressed within cells from eukaryotic promoters Scanlon et C_ 1991, Proc. Natl. Acad. Sci. USA, 88, 15 10591-5; Kas-.ani-Sabet et al., 1992 Antisense Res. Dev., 2, 3-15; Dropulic et al., 1992 J. Virol, 66, 1432-41; Weerasinghe et al., 1991 J. Virol, 65, 5531-4; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89, 10802-6; Chen et al., 1992 Nucleic Acids Res., 20, 4581-9; Sarver et 20 al., 1990 Science 247, 1222-1225). Those skilled in the art realize that any ribozyme can be expressed in eukaryotic cells from the appropriate DNA/RNA vector. The activity of such ribozymes can be augmented by their release from the primary transcript by a second ribozyme (Draper et al., PCT W093/23569, and Sullivan et al., PCT W094/02595, both hereby incorporated in their totality by reference herein; Ohkawa et al., 1992 Nucleic Acids Symp.

Ser., 27, 15-6; Taira et al., 1991, Nucleic Acids Res., 19, 5125-30; Ventura et al., 1993 Nucleic Acids Res., 21, 3249-55; Chowrira et al., 1994 J. Biol. Chem. 269, 25856).

Thus, in a first aspect, the invention features ribozymes that inhibit cell proliferation. These chemically or enzymatically synthesized RNA molecules contain substrate binding domains that bind to accessible regions of their target mRNAs. The RNA molecules also contain domains that catalyze the cleavage of RNA. The RNA molecules are preferably ribozymes of the hammerhead or hairpin motif. Upon binding, the ribozymes cleave the target mRNAs, preventing translation and protein accumulation. In the absence of the expression of the target gene, cell proliferation is inhibited.

In a preferred embodiment, the enzymatic RNA molecules cleave c-myb mRNA and inhibit smooth muscle cell proliferation. Such ribozymes are useful for the prevention of restenosis after coronary angioplasty. Ribozvmes are added directly, or can be complexed with cationic lipids, packaged within liposomes, or otherwise delivered to smooth muscle cells. The RNA or RNA complexes can be locally administered to relevant tissues through the use of a catheter, infusion pump or stent, with or without their incorporation in biopolymers. The ribozymes, simi- 15 larly delivered, also are useful for inhibiting proliferation of certain cancers associated with elevated levels of the c-myb oncogene, particularly leukemias, neuroblastomas, and lung, colon, and breast carcinomas. Using the methods described herein, other enzymatic RNA mole- 20 cules that cleave c-myb, c-myc, oct-1, SRF, NF-KB, PDGF receptor, bFGF receptor, angiotensin II, and endotheliumderived relaxing factor and thereby inhibit smooth muscle 99 *9 cell proliferation and/or tumor cell proliferation may be derived and used as described above. Specific examples are provided below in the Tables.

Such ribozymes are useful for the prevention of the diseases and conditions discussed above, and any other diseases or conditions that are related to the level of cmyb activity in a cell or tissue. By "related" is meant that the inhibition of c-myb mRNAs and thus reduction in the level of protein activity will relieve to some extent the symptoms of the disease or condition.

Ribozymes are added directly, or can be complexed with cationic lipids, packaged within liposomes, or otherwise delivered to target cells. The nucleic acid or nucleic acid complexes can be locally administered to relevant tissues ex vivo, or in vivo through injection, infusion pump or stent, with or without their incorporation in biopolymers.

In another aspect of the invention, ribozymes that cleave target molecules and inhibit c-myb activity are expressed from transcription units inserted into DNA or RNA vectors. The recombinant vectors are preferably DNA plasmids or viral vectors. Ribozyme expressing viral vectors could be constructed based on, but not limited to, adeno-associated virus, retrovirus, adenovirus, or alphavirus. Preferably, the recombinant vectors capable of expressing the ribozymes are delivered as described above, *and persist in target cells. Alternatively, viral vectors may be used that provide for transient expression of ribozymes. Such vectors might be repeatedly administered as necessary. Once expressed, the ribozymes cleave the target mRNA. Delivery of ribozyme expressing vectors could be systemic, such as by intravenous or intramuscular administration, by administration to target cells explanted from the patient followed by reintroduction into 20 the patient, or by any other means that would allow for introduction into the desired target cell.

bs By "vectors" is meant any nucleic acid- and/or viralbased technique used to deliver a desired nucleic acid.

In preferred embodiments, the ribozymes have binding arms which are complementary to the sequences in the tables II, XII-XXIV. Examples of such ribozymes are shown as Seq. I.D. Nos. 101-129 (table III) and in tables XII- XXIV. By complementary is thus meant that the binding arms are able to cause cleavage of a human or mouse or rat or porcine mRNA target. Examples of such ribozymes consist essentially of sequences defined in tables III, XII- XXIV. By "consists essentially of" is meant that the active ribozyme contains an enzymatic center equivalent to those in the examples, and binding arms able to bind c-myb mRNA such that cleavage at the target site occurs. Other sequences may be present which do not interfere with such cleavage.

In another aspect of the invention, ribozymes that cleave target molecules and inhibit cell proliferation are expressed from transcription units inserted into DNA, RNA, or viral vectors. Preferably, the recombinant vectors capable of expressing the ribozymes are locally delivered as described above, and transiently persist in smooth muscle cells. Once expressed, the ribozymes cleave their target mRNAs and prevent proliferation of their host cells. The recombinant vectors are preferably DNA plasmids or adenovirus vectors. However, other mammalian cell vectors that direct the expression of RNA may be used for this purpose.

Other features and advantages of the invention will be apparent from the following description of the pre- .9 15 ferred embodiments thereof, and from the claims.

Description Of The Preferred Embodiments The drawings will first briefly be described.

20 Drawings: Figure 1 is a diagrammatic representation of the hammerhead ribozyme domain known in the art. Stem II can be a 2 base-pair long.

Figure 2a is a diagrammatic representation of the hammerhead ribozyme domain known in the art; Figure 2b is a diagrammatic representation of the hammerhead ribozyme as divided by Uhlenbeck (1987, Nature, 327, 596-600) into a substrate and enzyme portion; Figure 2c is a similar diagram showing the hammerhead divided by Haseloff and Gerlach (1988, Nature 334, 585-591) into two portions; and Figure 2d is a similar diagram showing the hammerhead divided by Jeffries and Symons (1989, Nucl. Acids. Res., 17, 1371-1371) into two portions.

Figure 3 is a diagrammatic representation of the general structure of a hairpin ribozyme. Helix 2 (H2) is provided with a least 4 base pairs n is 1, 2, 3 or 4) and helix 5 can be optionally provided of length 2 or more bases (preferably 3 20 bases, m is from 1 or more). Helix 2 and helix 5 may be covalently linked by one or m:"e bases r is a 1 base). Helix 1, 4 or may also extended by 2 or more base pairs 4 20 base pairs) to stabilize the ribozyme structure, and preferably is a protein binding site. In each instance, each N and N' independently is any normal or modified base and each dash represents a potential base-pairing interaction. These nucleotides may be modified at tn- sugar, base or phosphate. Complete base-pairing is not required in the helices, but is preferred. Helix 1 and 4 can be of any size o and p is each independently from 0 to any number, ID) as .ong as some base-pairing is maintained. Essential basE-. are shown as specific bases 15 in the structure, but those -n the art will recognize that one or more may be modif: d chemically (abasic, base, sugar and/or phosphate moaifications) or replaced with another base without significant effect. Helix 4 can be formed from two separate molecules, without a con- 20 necting loop. The connecting loop when present may be a ribonucleotide with or without modifications to its base, sugar or phosphate. is a 2 bases. The connecting loop can also be replaced wir- a non-nucleotide linker molecule. H refers to bases A, U, or C. Y refers to pyrimidine bases. refers to a covalent bond.

Figure 4 is a representation of the general structure of the hepatitis delta virus ribozyme domain known in the art.

Figure 5 is a representation of the general structure of the self-cleaving VS RNA ribozyme domain.

Figure 6 is a schematic representation of an RNAseH accessibility assay. Specifically, the left side of Figure 6 is a diagram of complementary DNA oligonucleotides bound to accessible sites on the target RNA.

Complementary DNA oligonucleotides are represented by broad lines labeled A, B, and C. Target RNA is represented by the thin, twisted line. The right side of Figure 6 is a schematic of a gel separation of uncut target RNA from a cleaved target RNA. Detection of target RNA is by autoradiography of body-labeled, T7 transcript.

The bands common to each lane represent uncleaved target RNA; the bands unique to each lane represent the cleaved products.

Figure 7 is a graph of the results of an RNAseH accessibility assay of murine c-myb RNA. On the abscissa is the sequence number of the DNA oligonucleotide that is homologous to the ribozyme target site. The ordinate represents the percentage of the intact transcript that was cleaved by RNAse H.

Figure 8 is a graph of the outcome of an RNAseH accessibility assay of human c-myb mRNA. The graphs are labeled as in Figure 7.

Figure 9 shows the effect of chemical modifications on the catalytic activity of hammerhead ribozyme targeted to c-myb site 575. A) diagrammatic representation of 575 hammerhead ribozyme*substrate complex. 2'-O-methyl ribo- 20 zyme represents a hammerhead (HH) ribozyme containing 2'- O-methyl substitutions at five nucleotides in the 5' and 3' termini. 2'-O-methyl P=S ribozyme represents a hammerhead (HH) ribozyme containing 2'-O-methyl and phosphorothioate substitutions at five nucleotides in the 5' and 3' termini. 2'-C-allyl iT ribozyme represents a hammerhead containing ribose residues at five positions. The remaining 31 nucleotide positions contain 2'-hydroxyl group substitutions, wherein 30 nucleotides contain 2'-O-methyl substitutions and one nucleotide (U 4 contains 2'-C-allyl substitution. Additionally, 3' end of this ribozyme contains a linked inverted T. 2'-C-allyl P=S ribozyme is similar to 2'-C-allyl iT ribozyme with the following changes: five nucleotides at the 5' and 3' termini contain phosphorothioate substitutions and the ribozyme lacks the 3'-end inverted T modification. B) shows the ability of ribozymes described in Fig. 9A to inhibit smooth muscle cell proliferation.

Figure 10 shows the effect of 2'-C-allyl P=S 575 HH ribozyme concentration on smooth muscle cell proliferation. A plot of percent inhibition of smooth muscle cell proliferation (normalized to the effect of a catalytically inactive ribozyme) as a function of ribozyme concentration is shown.

Figure 11 shows a comparison of the effects of 2'-Callyl P=S 575 HH ribozyme and phosphorothioate antisense DNA on the proliferation of smooth muscle cells.

Figure 12 shows the inhibition of smooth muscle cell proliferation catalyzed by 2'-C-allyl P=S HH ribozymes targeted to sites 549, 575, and 1533 within c-mvb mRNA.

Figure 13 shows the effect of phosphorthioate substitutions on the catalytic activity of 2'-C-allyl 575 HH ribozyme. A) diagrammatic representation of 575 hammerhead ribozymeesubstrate complex. 10 P=S 5' and 3' ribozyme is identical to the 2'-C-allyl P=S ribozyme described in Fig. 9. 5 P=S 3' ribozyme is same as 10 P=S and 3' ribozyme, with the exception that only five 20 nucleotides at the 3' termini contain phosphorothioate substitutions. 5 P=S Loop ribozyme is similar to 2'-Callyl iT described in Fig. 9, with the exception that five nucleotides within loop II of this ribozyme contain phosphorothioate substitutions. 5 P=S 5' ribozyme is same as 10 P=S 5' and 3' ribozyme, with the exception that only five nucleotides at the 5' termini contain phospnorothioate substitutions. Additionally, this ribozyme contains a linked inverted T at its 3' end. B) shows the ability of ribozymes described in Fig. 13A to inhibit smooth muscle cell proliferation.

Figure 14 shows the minimum number of phosphorothioate substitutions required at the 5' termini of 575 HH ribozyme to achieve efficient inhibition of smooth muscle cell proliferation.

Figure 15 shows the effect of varying the length of substrate binding arm of 575 HH ribozyme on the inhibition of smooth muscle cell proliferation.

Figure 16 shows the effect of various chemical modifications, at U 4 and/or U 7 positions within 575 HH ribozyme core, on the ability of the ribozyme to inhibit smooth muscle cell proliferation.

Figure 17 shows the inhibition of pig smooth muscle cell proliferation by active c-myb 575 HH ribozyme.

Figure 18 shows the inhibition of human smooth muscle cell proliferation by active c-myb 575 HH ribozyme.

Figure 19 shows ribozyme-mediated inhibition of c-myb expression and cell proliferation.

Figure 20 is digrammatic representation of an optimal c-myb HH ribozyme that can be used to treat diseases like restenosis.

15 Figure 21 shows the inhibition of Rat smooth muscle S 15 cells by 2-5A containing nucleic acids.

Target sites Targets for useful ribozymes can be determined as disclosed in Draper et al supra, Sullivan et al., supra, 20 as well as by Draper et al., "Method and reagent for treatment of arthritic conditions PCT No. PCT/US94/13129, U.S.S.N. 08/152,487, filed 11/12/93, and hereby incorporated by reference herein in totality. Rather than repeat the guidance provided in those documents here, below are provided specific examples of such methods, not limiting to those in the art. Ribozymes to such targets are designed as described in those applications and synthesized to be tested in vitro and in vivo, as also described. Such ribozymes can also be optimized and delivered as described therein. While specific examples to mouse RNA are provided, those in the art will recognize that equivalent human RNA targets can be used as described below. Thus, the same target may be used, but binding arms suitable for targetting human RNA sequences are present in the ribozyme. Such targets may also be selected as described below.

The sequence of human, pig and murine c-myb mRNAs were screened for optimal ribozyme target sites using a computer folding algorithm. Hammerhead or hairpin ribozyme cleavage sites were identified. These sites are shown in Tables II and XII-XXI" (All sequences are 5' to 3' in the tables) The nucleotide base position is noted in the Tables as that site to be cleaved by the designated type of ribozyme. While murine, pig and human sequences can be screened and ribozymes ther .ter -signed, the human targeted sequences are of most utility. However, murine and pig targeted ribozymes may be useful to test efficacy c_ action of :ne ribozyme prior to testing in humans. Tne nucleotide base position is noted in the Tables as that site to be cleaved by the designated type 15 of ribozyme.

Hammerhead or hairpin ribozymes were designed that could bind and were individually analyzed by computer folding (Jaeger et al., 1989 Proc. Natl. Acad. Sci. USA, 86, 7706) to assess whether the ribozyme sequences fold 20 into the appropriate secondary structure. Those ribozymes with unfavorable intramolecular interactions between the binding arms and the catalytic core are eliminated from consideration. Varying binding arm lengths can be chosen to optimize activity. Generally, at least 5 bases on each arm are able to bind to, or otherwise interact with, the target RNA.

The sequences of the ribozymes that are chemically synthesized, useful in this study, are shown in Table III and XII-XXIV. Those in the art will recognize that these sequences are representative only of many more such sequences where the enzymatic portion of the ribozyme (all but the binding arms) is altered to affect activity. For example, stem-loop II sequence of hammerhead ribozymes listed in Table III (5'-GGCCGAAAGGCC-3') can be altered (substitution, deletion, and/or insertion) to contain any sequences provided a minimum of two base-paired stem structure can form. Similarly, stem-loop IV sequence of hairpin ribozymes listed in Table III, XIII, XVI, XIX, XX, XXIII, XXIV (5'-CACGUUGUG-3') can be altered (substitution, deletion, and/or insertion) to contain any sequence, provided a minimum of two base-paired stem structure can form. The ribozyme sequences listed in Table III and XII- XXIV may be formed of ribonucleotides or other nucleotides or non-nucleotides. Such ribozymes are equivalent to the ribozymes described specifically in the Tables.

Optimizing Ribozyme Activity Ribozyme activity can be optimized as described in this application. These include altering the length of the ribozyme binding arms (stems I and III, see Figure 2c), or chemically synthesizing ribozymes with modifica- 15 tions that prevent their degradation by serum ribonucleases (see Eckstein et al., International Publication No. WO 92/07065; Perrault et al., 1990 Nature 344, 565; Pieken et al., 1991 Science 253, 314; Usman and Cedergren, 1992 Trends in Biochem. Sci. 17, 334; Usman et 20 al., International Publication No. WO 93/15187; and Rossi et al., International Publication No. WO 91/03162, as well as Usman, N. et al. US Patent Application 07/829,729, and Sproat, US Patent No. 5, 334, 711 which describe various chemical modifications that can be made to the sugar moieties of enzymatic RNA molecules, modifications which enhance their efficacy in cells, and removal of stem II bases to shorten RNA synthesis times and reduce chemical requirements. (All these publications are hereby incorporated by reference herein.) Sullivan, et al., supra, describes the general methods for delivery of enzymatic RNA molecules.

Ribozymes may be administered to cells by a variety of methods known to those familiar to the art, including, but not restricted to, encapsulation in liposomes, by iontophoresis, or by incorporation into other vehicles, such as hydrogels, cyclodextrins, biodegradable nanocapsules, and bioadhesive microspheres. For some indications, ribozymes may be directly delivered ex vivo to cells or tissues with or without the aforementioned vehicles. Alternatively, the RNA/vehicle combination is locally delivered by direct injection or by use of a catheter, infusion pump or stent.

Other routes of delivery include, but are not limited to, intravascular, intramuscular, subcutaneous or joint injection, aerosol inhalation, oral (tablet or pill form), topical, systemic, ocular, intraperitoneal and/or intrathecal delivery. More detailed descriptions of ribozyme delivery and administration are provided in Sullivan et al. supra and Draper et al., supra which have been in=o--orated by reference herein.

Another means of accumulating high concentrations of a ribozyme(s) within cells is to incorporate the ribozyme- 15 encoding sequences into a DNA or RNA expression vector.

Transcription of the ribozyme sequences are driven from a promoter for eu :aryotic RNA polymerase I (pol I) RNA polymerase II (pol II), or RNA polymerase III (pol III) Transcripts from pol II or pol III promoters will be 20 expressed at high levels in all cells; the levels of a agiven pol II promoter in a given cell type will depend on the nature of the gene regulatory sequences (enhancers, a. '*silencers, etc.) present nearby. Prokaryotic RNA polymerase promoters are also used, provicing that the prokaryotic RNA polymerase enzyme is expressed in the appropriate cells (Elroy-Stein and Moss, 1990 Proc. Natl. Acad. Sci.

U S A, 87, 6743-7; Gao and Huang 1993 Nucleic Acids Res., 21, 2867-72; Lieber et al., 1993 Methods Enzymol., 217, 47-66; Zhou et al., 1990 Mol. Cell. Biol., 10, 4529-37).

Several investigators have demonstrated that ribozymes expressed from such promoters can function in mammalian cells Kashani-Sabet et al., 1992 Antisense Res.

Dev., 2, 3-15; Ojwang et al., 1992 Proc. Natl. Acad.

Sci. U S A, 89, 10802-6; Chen et al., 1992 Nucleic Acids Res., 20, 4581-9; Yu et al., 1993 Proc. Natl. Acad. Sci.

U S A, 90, 6340-4; L'Huillier et al., 1992 EMBO J. 11, 4411-8; Lisziewicz et al., 1993 Proc. Natl. Acad. Sci.

U. S. 90, 8000-4). The above ribozyme transcription units can be incorporated into a variety of vectors for introduction into mammalian cells, including but not restricted to, plasmid DNA vectors, viral DNA vectors (such as adenovirus or adeno-associated virus vectors), or viral RNA vectors (such as retroviral or alphavirus vectors).

In a preferred embodiment of the invention, a transcription unit expressing a ribozyme that cleaves mRNAs encoded by c-myb is inserted into a plasmid DNA vector or an adenovirus or adeno-associated virus DNA viral vector or a retroviral RNA vector. Viral vectors have been used I to transfer genes and lead to either transient or long term gene expression (Zabner et al., 1993 Cell 75, 207; 15 Carter, 1992 Curr. ODi. Biotech. 3, 533). The adenovirus vector is delivered as recombinant adenoviral particles.

*The DNA may be delivered alone or complexed with vehicles (as described for RNA above). The recombinart adenovirus or AAV particles are locally administered to the site of 20 treatment, through incubation or inhalation in vivo or by direct application to cells or tissues ex vivo.

In another preferred embodiment, the ribozyme is administered to the site of c-myb expression smooth muscle cells) in an appropriate liposomal vesicle.

Examples Ability Of Exogenously-Delivered Ribozymes Directed Against c-mvb To Inhibit Vascular Smooth Muscle Cell Proliferation The following examples demonstrate the selection of ribozymes that cleave c-myb mRNA. The methods described herein represent a scheme by which ribozymes may be derived that cleave other mRNA targets required for cell division. Also provided is a description of how such ribozymes may be delivered to smooth muscle cells. The examples demonstrate that upon delivery, the ribozymes inhibit cell proliferation in culture. Moreover, no inhibition is observed if mutated ribozymes that are catalytically inactive are applied to the cells. Thus, inhibition requires the catalytic activity of the S'ozymes. The cell division assay used represents a n- el system for smooth muscle cell hyperproliferation in restenotic lesions.

Example 1: Identification of Potential Ribozyme Cleavaae Sites in Human c-myb mRNA The sequence of human c-myb mRNA was screened for accessible sites using a computer folding algorithm.

Regions of the mRNA that did not form secondary folding structures and contained potential hammerhead ribozyme cleavage sites were identified. These sites are shown in 15 Table II and XII-XXIV Sites are numbered using the sequence numbers from (Westin, E. et al., 1990, Oncoqene, 5, 1117-1124) (GenBank Accession No. X52125) the sequence is derived from a longer c-myb cDNA isolate and thus is more representative of the full-length RNA.

*Example 2: Selection of Ribozyme Cleavage Sites in Murine and Human c-myb mRNA.

To test whether the sites predicted by the computerbased RNA folding algorithm corresponded to accessible sites in c-myb RNA, 41 hammerhead sites were selected for analysis. Ribozyme target sites were chosen by comparing cDNA sequences of mouse and human c-myb (GenBank Accession No. X02774 and GenBank Accession No. X52125, respectively) and prioritizing the sites on the basis of overall nucleotide sequence homology. Hammerhead ribozymes were designed that could bind each target (see Figure 2C) and were individually analyzed by computer folding (Jaeger, J.

et al., 1989, Proc. Natl. Acad. Sci. USA, 86, 7706- 7710) to assess whether the ribozyme sequences fold into the appropriate secondary structure. Those ribozymes with unfavorable intramolecular interactions between the binding arms and the catalytic core were eliminated from consideration. As noted below, varying binding arm lengths can be chosen to optimize activity. Generally, at least 5 bases on each arm are able to bind to, or otherwise interact with, the target RNA.

Example 3: Screening Ribozyme Cleavage Sites by RNaseH Protection Murine and human mRNA was screened for accessible cleavage sites by the method described generally in Draper et al., International PCT publication WO 93/23569, hereby incorporated by reference herein. Briefly, DNA oligonucleotides representing 41 potential hammerhead ribozyme cleavage sites were synthesized. A polymerase chain reaction was used to generate a substrate for T7 RNA S* 15 polymerase transcription from human or murine c-myb cDNA clones. Labeled RNA transcripts were synthesized in vitro from the two templates. The oligonucleotides and the labeled transcripts were annealed, RNAseH was added and the mixtures were incubated for the designated times at *oe 20 370 C. Reactions were stopped and RNA separated on sequencing polyacrylamide gels. The percentage of the substrate cleaved was determined by autoradiographic quantitation using a phosphor imaging system. The results are shown in Figures 7 and 8. From these data, hammerhead ribozyme sites were chosen as the most accessible (see Table III) Example 4: Chemical Synthesis and Purification of Ribozymes for Efficient Cleavage of c-myb RNA Ribozymes of the hammerhead or hairpin motif were designed to anneal to various sites in the mRNA message.

The binding arms are complementary to the target site sequences described above. The ribozymes were chemically synthesized. The method of synthesis used followed the procedure for normal RNA synthesis as described in Usman et al., 1987 J. Am. Chem. Soc., 109, 7845 and in Scaringe et al., 1990 Nucleic Acids Res., 18, 5433 and made use of common nucleic acid protecting and coupling groups, such as dimethoxytrityl at the 5'-end, and phosphoramidites at the 3'-end. The average stepwise coupling yields were Inactive ribozymes were synthesized by substituting a U for G 5 and a U for A, 4 (numbering from Hertel et al., 1992 Nucleic Acids Res., 20, 3252). Hairpin ribozymes were synthesized in two parts and annealed to reconstruct the active ribozyme (Chowrira and Burke, 1992 Nucleic Acids Res., 20, 2835-2840). Ribozymes were also synthesized from DNA templates using bacteriophage T7 RNA polymerase (Milligan and Uhlenbeck, 1989, Methods Enzymol.

180, 51). All ribozymes were modified extensively to enhance stability by modification with nuclease resistant groups, for example, 2'-amino, 2'-C-allyl, 2'-flouro, 2'c* *t :'15 0-methyl, 2'-H (for a review see Usman and Cedergren, 1992 TIBS 17, 34) Ribozymes were purified by gel electrophoresis using general methods or were purified by high pressure liqu-; chrm.atography (HPLC; See Usman et al., Synthesis, deprotect analysis and purification of RNA 20 and ribozymes, filed May, 18, 1994, U.S.S.N. 08/245,736 the totality of which is hereby incorporated herein by re:erence) and were resuspended in water. The sequences of the chemic-_ly sy-thesized ribozymes used in this study are shown below in Table III.

Example 5: Ribozyme Cleavage of Lona Substrate RNA Corresponding to c-myb mRNA Target Hammerhead-type ribozymes which were targeted to the murine c-myb mRNA were designed and synthesized to test the cleavage activity at the 20 most accessible sites in in vitro transcripts of both mouse and human c-myb RNAs.

The target sequences and the nucleotide location within the c-myb mRNA are given in Table II. All hammerhead ribozymes were synthesized with binding arm (Stems I and III; see Figure 2C) lengths of seven nucleotides. Two hairpin ribozymes were synthesized to sites 1632 and 2231.

The relative abilities of these ribozymes to cleave both murine and human RNAs is summarized in Table II Ribozymes (1 M) were incubated with 32 P-labeled substrate RNA (prepared as described in Example 3, approximately nM) for 60 minutes at 37 0 C using buffers described previously. Intact RNA and cleavage products were separated by electrophoresis through polyacrylamide gels. The percentage of cleavage was determined by Phosphcr ImagerL quantitation of bands representing the intact substrate and the cleavage products.

Five hammerhead ribozymes (directed against sites 549, 575, 1553, 1597, and 1635) and one hairpir ribozyme (directed against site 1632) were very active; they cleaved >70% of both murine and human c-myb RNA in minutes. Nine of the hammerhead ribozymes (directed 15 against sites 551, 634, 936, 1082, 1597, 1721, 1724 1895 and 1943) were intermediate in activity, cleaving 50% of both murine and human c-myb RNA in 60 minutes. All of the sites cleaved by these active ribozymes were predicted to be accessible to ribozyme cleavage in Table II. Six hammerhead ribozymes and one hairpin ribozyme showed low activity on at least one of the substrates. The observed differences in accessibility between the two species of cmyb RNA demonstrate the sensitivity of ribozyme action to RNA structure and suggest that even when homologous target 25 sequences exist, ribozymes may be excluded from cleaving that RNA by structural constraints. This level of specificity minimizes non-specific toxicity of ribozymes within cells.

Example 6: Ability of Hammerhead Ribozvmes to Inhibit Smooth Muscle Cell Proliferation.

The ribozymes that cleaved c-myb RNA described above were assayed for their effect on smooth muscle cell proliferation. Rat vascular smooth muscle cells were isolated and cultured as follows. Aortas from adult Sprague-Dawley rats were dissected, connective tissue was removed under a dissecting microscope, and 1 mm 2 pieces of the vessel were placed, intimal side up, in a Petri dish in Modified Eagle's Medium (MEM) with the following additives: 10% FBS, 2% tryptose phosphate broth, 1% penicillin/streptomycin -nd 2 m. L-Gluta-.ne. The oth muscle cells were allowed to migrate ane grow to c- luence over a 3-4 week period. These primary cells were frozen and subsequent passages were grown at 37c c

CO

2 in Dulbecco's modified Eagle's medium (DMEM), 10% fetal bovine serum (FBS), and the following additives: 2 ml L- Glutamine, 1% penicillLn/streptomycin, mM sodium pyruvate, non-essential am-no acids (0.1 of each amino acid), and 20 mM Hepes pH 7.4. Cells passed four to six times were used in proliferation assays. For the cell proliferation assays, 24-well tissue culture plates were prepared by coating the wells with 0.2% gelatin and washing once with phosphate-buffered saline (PBS). RASMC 4 S* were inoculated at ix104 cells per well in 1 ml of DMEM plus 10% FBS and additives and incubated for 24 hours.

The cells were subconfluent when plated at this density.

20 The cells were serum-starved by removi: the medium, washing once with PBS, and incubating 48 hours in DMEM Scontaining 0.5% FBS plus additives.

In several other systems, cationic lipids have been shown to enhance the bioavailability of oligonucleotides to cells in culture (Bennet, C. et al., 1992, Mol.

S" Pharmacoloqy, 41, 1023-1033). In many of the following experiments, ribozymes were complexed with cationic lipids. The cationic lipid, Lipofectamine (a 3:1 (w/w) formulation of DOSPA (2,3-dioleyloxy-N-[2(sperminecarboxamido)ethyl]-N,N-dimethyl-1-propanaminium trifluoroacetate) and dioleoyl phosphatidylethanolamine (DOPE)), was purchased from Life Technologies, Inc. DMRIE ditetradecyloxy propyl]-N, N-dimethyl-N-hydroxyethylammonium bromide was obtained from VICAL. DMRIE was resuspended in CHC1 3 and mixed at a 1:1 molar ratio with dioleoyl phosphatidylethanolamine (DOPE). The CHC1 3 was evaporated, the lipid was resuspended in water, vortexed for 1 minute and bath sonicated for 5 minutes. Ribozyme and cationic lipid mixtures were prepared in serum-free DMEM immediately prior to addition to the cells. DMEM plus additives was warmed to room temperature (about 25 0 cationic lipid was added to the final desired concentration and the solution was vortexed briefly. RNA oligonucleotides were added to the final desired concentration and the solution was again vortexed briefly and incubated for 10 minutes at room temperature. In dose response experiments, the RNA/lipid complex was serially diluted into DMEM following the 10 minute incubation.

Serum-starved smooth muscle cells were washed twice with PBS, and the RNA/lipid complex was added. The plates were incubated for 4 hours at 37 0 C. The medium was then 15 removed and DMEM containing 10% FBS, additives and 10 4M bromodeoxyuridine (BrdU) was added. In some wells, FBS was omitted to determine the baseline of unstimulated proliferation. The plates were incubated at 37 0 C for '.24 hours, fixed with 0.3% H 2 0 2 in 100% methanol, and stained for BrdU incorporation by standard methods. In this procedure, cells that have proliferated and incorporated BrdU stain brown; non-proliferating cells are counter-stained a light purple. Both BrdU positive and BrdU negative cells were counted under the microscope.

25 300-600 total cells per well were counted. In the following experiments, the percentage of the total cells that have incorporated BrdU cell proliferation) is presented. Errors represent the range of duplicate wells.

Percent inhibition then is calculated from the cell proliferation values as follows: inhibition 100 100((Ribozyme 0% serum)/(Control 0% serum)).

Six hammerhead ribozymes, including the best five ribozymes from the in vitro RNA cleavage test (directed against sites 549, 575, 1553, 1598, and 1635) and one with intermediate cleavage levels (directed against site 1597) and their catalytically inactive controls were synthesized and purified as described above. The ribozymes were delivered at a concentration of 0.3 pM, complexed with DMRIE/DOPE such that the cationic lipid charges and the anionic RNA charges were at 1:1 molar ratio. The results, shown in Table IV, demonstrate a considerable range in the efficacy of ribozymes directed against differen: sites.

Five of the six hammerhead ribozymes (directed against sites 549, 575, 1553, 1597, and 1598) significantly inhibit smooth muscle cell proliferation. The control, inactive ribozymes that cannot cleave c-myb RNA due to alterations in their catalytic core sequence fail to inhibit rat smooth muscle cell proliferation. Thus, inhibition of cell proliferation by these five hammerhead sequences is due to their ability to cleave c-myb RNA, and not because of any antisense activity. The sixth ribozyme 15 (directed against site 1635) fails to function in smooth muscle cells. This ribozyme cleaved c-myb RNA very efficiently in vitro. In this experiment, 10% FBS (no ribozyme added) induced 64 1% proliferation; 0% FBS produced a background of 9 1% proliferation.

Example 7: Ability of exogenously delivered hairpin ribozyme against c-myb to inhibit vascular smooth muscle cell proliferation In addition to the hammerhead ribozymes tested above, 25 .a bipartite hairpin ribozyme (Chowrira, B. supra, 1992, Nucleic Acids Res., 20, 2835-2840) was identified that also cleaves c-myb RNA. The effect of this ribozyme on smooth muscle cell proliferation was tested. Ribozymes were delivered at the indicated doses with Lipofectamine at a 1:1 charge ratio. In this experiment, 10% FBS (no ribozyme) induced 87 1% proliferation; 0% FBS produced 1% proliferationr The results of a dose-response experment are shown in Table V. In this example, the control was an irrelevant hammerhead ribozyme. The irrelevant ribozyme control contains the same catalytic core sequences, but has binding arms that are directed to a cellular RNA that is not required for smooth muscle cell proliferation. This control failed to significantly inhibit cell proliferation, demonstrating the sequence specificity of these ribozymes. Another control that could be run is an irrelevant catalytically active ribozyme having the same G:C content as the test ribozyme.

Example 8: Ribozymes inhibit proliferation of rat smooth muscle cells in a dose-dependent fashion.

If the inhibition of proliferation observed in Example 6 is caused by the ribozymes, the level of inhibition should be proportional to the dose of RNA added. Rat aortic smooth muscle cells were assayed for proliferation in the presence of differing doses of two hammerhead ribozymes. The results shown in Table VI indicate that two 15 hammerhead ribozymes that cleave c-myb RNA at sites 575 and 549 inhibit SMC proliferation in a dose-dependent fashion. Ribozymes were delivered with the cationic lipid, Lipofectamine at a 1:1 charge ratio. In this experiment, 10% FBS (no ribozyme) gave 92 1% proliferation; 0% FBS gave 6 1% proliferation. The control is an active ribozyme directed against an irrelevant mRNA target and shows no inhibition over the dose range tested. The control ribozyme contains the same catalytic core sequences as the active ribozymes but differs in its 25 binding arm sequences (stems I and III in Figure 2c) Thus, ribozyme inhibition of smooth muscle cell proliferation requires sequence-specific binding by the hammerhead arms to c-myb mRNA.

Example 9: Delivery of a c-mvb Ribozyme With Different Cationic Lipids The experiment in Table VII shows the response of rat smooth muscle cells to a hammerhead ribozyme that cleaves c-myb RNA at site 575 delivered with two different cationic lipids, DMRIE and Lipofectamine. Similar efficacy is observed with either lipid. 10% FBS (no ribozyme) induced 78 2% proliferation; 0% FBS produced a background of 6 1% proliferation.

Example 10: Effect of varying arm-lengths on ribozyme activity.

The exact configuration of each ribozyme can be optimized by altering the length of the binding arms (stems I and III, see Figure 2C). The length of the binding arms may have an effect on both the binding and the catalytic cleavage step (Herschlag, 1991, Proc.

Natl. Acad. Sci. U S A, 88, 6921-5). For example, Table VIII shows the ability of arm length variants of c-myb hammerhead 575 to inhibit SMC proliferation. Note that the dose used in this experiment (0.1 iM) is 3-fold lower 15 than in previous experiments. At this concentration, the 7/7 arm variant gives relatively little inhibition. In this case, the degree of inhibition increases with concomitant increases in arm length.

The optimum arm length may be site-specific and should be determined empirically for each ribozyme.

~Towards this end, hammerhead ribozymes target with 7 nucleotide binding arms and ribtzymes with 12 nucleotide binding arms (12/12) targeted to three Sdifferent cleavage sites were compared.

S" 25 Ribozymes were delivered at 0.2 iM with the cationic lipid DMRIE at a 1:1 charge ratio of oligonucleotide to cationic lipid as described in Example 6. The data are shown below in Table IX. As can be seen, all three ribozymes demonstrated enhanced inhibition of smooth muscle cell proliferation with twelve nucleotide binding arms. Each ribozyme showed greater inhibition than its catalytically inactive control, again demonstrating that the ribozymes function via their ability to cleave c-myb RNA. In this experiment, 10% stimulation resulted in 54 2 cell proliferation; unstimulated cells showed 8 cell proliferation.

Example 11: Effect of chloroquine on ribozvme activity A number of substances that effect the trafficking of macromolecules through the endosome have been shown to enhance the efficacy of DNA delivery to cells. These include, but are not limited to, ammonium chloride, carbonyl cyanide p-trifluoromethoxy phenyl hydrazone (FCCP), chloroquine, monensin, colchicine, and viral particles (Cotten, M. et al.,1990, Proc. Natl. Acad. Sci.

USA 87, 4033-4037; Cotten, M. et al.,1993, J. Virol.

67, 3777-3785; Cotten, M. et al.,1992, Proc. Natl. Acad.

Sci. USA 89, 6094-6098; Cristiano, R. J. et al.,1993, Proc. Natl. Acad. Sci. U S A 90, 2122-6; Curiel, D. T.

et al.,1991, Proc. Nat. Acad. Sci. USA 88, 8850-8854; Ege, T. et al.,1984, Exp. Cell Res. 155, 9-16; Harris, 15 C. E. et al.,1993, Am. J. Respir. Cell Mol. Biol. 9, 441-7; Seth, P. et al.,1994, J. Virol. 68, 933-40; Zenke, M. et al.,1990, Proc. Natl. Acad. Sci. USA 87, 3655-3659). It is thought that DNA is taken up by cells by endocytosis, resulting in DNA accumulation in endosomes (Akhtar, S. and Juliano, R. L.,1992, Trends Cell Biol.

2, 139-144). Thus, the above agents may enhance DNA expression by promoting DNA release from endosomes. To determine whether such agents may augment the functional Sdelivery of RNA and ribozymes to smooth muscle cells, the 25 effects of chloroquine on ribozyme inhibition of smooth muscle cell proliferation were assessed. A ribozyme with twelve nucleotide binding arms that cleaves c-mby RNA was delivered to rat smooth muscle cells as described in Example 6 (0.2 yM ribozyme complexed with DMRIE/DOPE at a 1:1 charge ratio). In some cases, 10 gM chloroquine was added upon stimulation of the cells. The addition of chloroquine had no effect on untreated cells (stimulation with 10% serum in the presence or absence of chloroquine resulted in 80.5 1.5 and 83 2% cell proliferation, respectively; unstimulated cells with and without chloroquine showed 7 0.5% and 7 1% cell proliferation, respectively). As shown in Table X below, addition of chloroquine augments ribozyme inhibition of smooth muscle cell proliferation two- to three-fold.

Example 12: Effect of a hammerhead ribozvme on human smooth muscle cell proliferation.

The hammerhead ribozyme that cleaves human c-myb RNA at site 549 was tested for its ability to inhibit human aortic smooth muscle cell proliferation. The binding site for this ribozyme is completely conserved between the mouse and human cDNA sequences. Human aortic smooth muscle cells (AOSMC) were obtained from Clonetics and were grown in SmGM (Clonetics Cells from passage five or six were used for assays. Conditions for the proliferation assay were the same as for the rat cells (see Example 6), 15 except that the cells were plated in SmGM and starved in

S

SmBM plus 0.5% FBS. The ribozyme that cleaves site 549 was delivered at varying doses complexed with the cationic S:lipid DMRIE at a 1:1 charge ratio. In this experiment, 10% FBS (no ribozyme) induced 57 7% proliferation; the uninduced background was 6 1% proliferation. The results in Table XI show that inhibition is observed over a similar concentration range as was seen with rat smooth muscle cells.

Example 13: Inhibition by direct addition of a modified, stabilized ribozyme.

A hammerhead ribozyme that cleaves site 575 was chemically synthesized with 12 nullez .de binding arms (sequence ID NO. 127, in Table III). C. -ically modified nucleotides were incorporated into this &ozyme that have been shown to enhance ribozyme stability in serum without greatly impacting catalytic activity. (See Eckstein et al., Int -:ational Publication No. WO 92/07065, Perrault et al., 90, Ns -re 344, 565-568 Pieken,W. et al.

1991, nce -53, 314-317, Usman,N.; Cederc in,R.J., 1992, Trends in Biochem. Sci., 17, 334-339, Usman,N. et al. US Patent Application 07/829,729, and Sproat,B.

European Patent Application 92110298.4 describe various chemical modifications that can be made to the sugar moieties of enzymatic RNA molecules. All these publications are hereby incorporated by reference herein.) The modifications used were as follows. All the nucleotides of the ribozyme contained 2'-O-methyl groups with the following exceptions: U 4 and U 7 contained 2'-amino substitutions; Ag, G8, G12, and A 15i were 2'-OH ribonucleotides (numbering as in Figure An inactive ribozyme was chemically synthesized in which G 5 and A 14 were substituted with 2'-O-methyl U. Ribozymes were added to rat smooth muscle cells at the indicated concentrations as per *Example 6 except that cationic lipids were omitted.

Proliferation was assessed by BrdU incorporation and 15 staining. Table XII shows that the modified ribozyme is S' capable of inhibiting rat smooth muscle cell proliferation without addition of cationic lipids. In this experiment, 10% serum induced 45 2 proliferation while uninduced cells showed a background of 2.3 0.1 proliferation.

Optimizing Ribozyme Activity As demonstrated in the above examples, ribozymes that cleave c-myb RNA are capable of inhibiting 50% of the smooth muscle cells from proliferating in response to serum. This level of inhibition does not represent the maximal effect obtainable with the ribozymes; in each dose response experiment, the highest dose produced the greatest extent of inhibition. Thus, optimizing activity of the ribozyme within the cells and/or optimizing the delivery of the ribozyme to the cells is expected to increase the extent of inhibition.

Tables VIII and IX demonstrate one means of optimizing ribozyme activity. By altering the length of the ribozyme binding arms (stems I and III, see Figure 2c), the ability of the ribozyme to inhibit smooth muscle cell proliferation is greatly enhanced. Ribozymes with increasing arm lengths will be synthesized either chemically in one or two parts (see above and see Mamone, U.S.

Serial No. 07/882,689, filed May 11, 1992, hereby incorporated by reference herein) or by in vitro transcription (see Cech et al., U.S. Patent 4.987,071). Ribozymes are chemically sy-- -esizec with modifications that prevent their degradat_. by ser-m ribonucieases (as described in Example 13, above). When synthesized in two parts, the fragments are ligated or otherwise juxtaposed as described (see original application and Mamone, supra). The effects of the ribozymes on smooth muscle cell proliferation are assessed as in Examples 6 and 12, above. As the length of *stems I and III can affect both hybridization to the *target and the cata_.-tic rate, the arm length of :=h ribozyme will be optimized for maximal inhibitory e ct 15 in cells. Similarly. -ne precise sequence of modified nucleotides in the -abilized ribozyme will affect the activity in cells. -ne nature of the :-abilizing modifi- S cations will be optimized for maximal -nnibitory effect in cells. In each case, activity of the ribozyme that cleaves c-myb RNA will be compared to the activity of its catalytically inac- ve control (substitution of *see methyl U for G 5 and methyl U for A 1 4 and to a ribozyme targeted to an irrelevant RNA (same catalytic core, with appropriate modifications, but different binding arm sequences).

Sullivan, et al., supra, describes the general methods for delivery of enzymatic RNA molecules. The data presented in Example 9 indicate that different cationic lipids can deliver active ribozymes to rat smooth muscle cells. In this example, 0.6 iM ribozyme delivered with Lipofectamine produced the same inhibitory effect as 0.3 4M ribozyme delivered with DMRIE. Thus, DMRIE is twice as efficacious as Lipofectamine at delivering active ribozymes to smooth muscle cells. There are a number of other cationic lipids known to those skilled in the art that can be used to deliver nucleic acid to cells, including but not limited to dioctadecylamidoglycylspermine (DOGS), dioleoxltrimetylammonium propane (DOTAP), N- dioleoyloxy)-propyl]-n,n,n-trimethylammoniumchloride (DOTMA), 2 ,3-dioleoyloxy)-propyl]-N,N-dimethyl-Nhydroxyethylammonium bromide (DORIE), and dioleoyloxy)propyl]-N,N-dimethyl-N-hydroxypropylammonium bromide (DORIE-HP). Experiments similar to those performed in Example 9 are used to determine which lipids give optimal delivery of ribozymes to smooth muscle cells.

Other such delivery methods are known in the art and can be utilized in this invention.

The data described in Example 11 show that ribozyme delivery and efficacy may be augmented by agents that disrupt or alter cellular endosome metabolism.

Chloroquine was shown to increase the ability of a 15 ribozyme to inhibit smooth muscle cell proliferation by 2to 3-fold. Experiments similar to those described in Example 11 can be performed to determine the optimal concentration of chloroquine to be used to augment delivery of ribozymes alone (as in Example 13), or delivery in the presence different cationic lipids (as in Example 9 and described above) or with other delivery agents (as described below). Other agents that disrupt or alter endosomes known to those familiar with the art can be used to similarly augment ribozyme effects. These agents may include, but are not limited to, ammonium chloride, carbonyl cyanide p-trifluoromethoxy phenyl hydrazone (FCCP), chloroquine, monensin, colchicine, amphipathic peptides, viral proteins, and viral particles. Such compounds may be used in conjunction with ribozymes as described above, may be chemically conjugated directly to ribozymes may be chemically conjugated to liposomes, or may be incorporated with ribozymes in liposome particles (see Sullivan, et al., supra, incorporated by reference herein).

The data presented in Example 13 indicate that the proliferation of smooth muscle cells can be inhibited by the direct addition of chemically stabilized ribozymes.

Presumably, uptake is mediated by passive diffusion of the anionic nucleic acid across the cell membrane. In this case, efficacy could be greatly enhanced by directly coupling a ligand to the ribozyme. The ribozymes are then delivered to the cells by receptor-mediated uptake. Using such conjugated adducts, cellular uptake can be increased by several orders of magnitude without having to alter the phosphodiester linkages necessary for ribozyme cleavage activity.

Alternat .ely, ribozymes may be administered to cells by a variety of methods known to those familiar to the art, including, but nc- restricted to, encapsulation in liposcmes, by iontop e.-sis or by incorporation into othe: -ehicles, such a-s hycrogels, cyclodextrins, bio- 15 degra able nanocapsules, and bioadhesive microspheres.

The RNA/vehicle combination is locally delivered by direct injection or by use of a catheter, infusion pump or stent.

Alternative routes of delivery include, but are not limited to, irnramuscular injection, aerosol inhalation, oral (tablet pill form), topical, systemic, ocular, intraperitonea_ and/or intrathecal delivery. More detailed descriptions of ribozyme delivery and administration are provided in Sullivan, et al., supra and Draper, 9. et al., supra which have been incorporated by reference herein.

Example 14: Phosphorothioate linkages enhance the ability of ribozymes to inhibit smooth muscle cell proliferation.

As the applicant had shown in Example 13, the hammerhead (HH) ribozyme that cleaves c-myb RNA at site 575 can be modified to confer resistance to nucleases while maintaining catalytic activity (see also Usman et al., supra) To identify ribozymes with optimal activity in cells, several different chemically-modified ribozymes were directly compared for inhibition of rat smooth muscle cell proliferation. Non-limiting examples of chemically-modified ribozymes used are diagrammed in Figure 9A. One ribozyme (designated "2'-O-methyl") contains ribonucleotide residues at all positions except the 5 terminal nucleotides of each target binding arm (Stems I and III) The ribozyme designated "2'-O-methyl P=S" in addition contains five phosphorothioate linkages between the terminal nucleotides in each target binding arm. The ribozyme termed "2'-C-allyl iT" contains thirty 2'-O-methyl nucleotides as specified in Example 13. The ribozyme also contains 2'-C-allyl U (Usman et al., 1994 Nucleic Acids Symp.

Ser. 31, 163) at the U4 position and 2'-O-methyl U at the U7 position and a 3'-3'-linked inverted thymidine (Ortigao et al., 1992 Antisense Res. Development 2, 129; Seliger et al., Canadian Patent Application No. 2,106,819) at the 3' end of the molecule (referred to as 2'-C-allyl iT) S. 15 The fourth ribozyme contains the same 2'-O-methyl and 2- C-allyl residues described above with the addition of phosphorothioate linkages between the terminal nucleotides in each target binding arm (referred to as "2'-C-allyl Ribozymes were delivered to smooth muscle cells as cationic lipid complexes (Sullivan et al., supra). In this example, the cationic lipid, Lipofectamine

(GIBCO-

BRL), was used at a charged lipid concentration of 3.6 4M S(see Examples 6 and Active versus inactive forms of 25 each ribozyme were compared to determined whether inhibition is mediated specifically by ribozyme cleavage. As shown in Figure 9B, the ribozyme synthesized with the 2'- C-allyl modification and the phosphorothioate linkages demonstrated enhanced inhibition of smooth muscle cell proliferation. The catalytically inactive form of the ribozyme had little effect on cell proliferation; thus, the inhibition observed requires the catalytic activity of the ribozyme. In contrast, ribozymes without the stable 2'-O-methyl- and 2'-C-allyl-modified catalytic core methyl and 2'-O-methyl P=S) at best showed only modest inhibition of smooth muscle cell proliferation. The stable core chemistry alone was not sufficient to greatly enhance ribozyme-mediated inhibition; without terminal P=S linkages, the 2 -C-allyl-modified ribozyme showed very little specific inhibition when compared to its inactive ribozyme control. These results demonstrate that certain chemical modifications greatly enhance the ability of exogenously-delivered ribozymes to cleave c-myb RNA and impact cell prolifer zon Example 15: Dose reoonse of the chemically modified ribozvme.

Varying doses of the 2'-C-allyl P=S-modified ribozyme were delivered to rat aortic smooth muscle cells as described above. As in previous examples, percent inhibition was cc-culated by comparing the effects of the active ribozyme to the effects of the inactive ribozyme. As o. I shown in Figure 10, the ribozyme concentration at which cell proliferation is inhibited by 50% (IC 50 is approximately 70 nM. From day to day, the IC50 varies between and 100 nM.

*Example 16: Direct comparison of the effects of ribozymes and antisense DNA.

Ribozymes are thought to be more specific reagents Sfor the inhibition of gene expression than antisense 25 oligonucleotides due to their catalytic activity and strict sequence requirements around the site of cleavage (Castanotto et al., 1994 Adv. in Pharmacol. 25, 289) To test this hypothesis, ribozyme activity was directly compared to the activity of phosphorothioate DNA oligonucleotides that target the same site in the c-myb mRNA. The ribozyme used was the 2'-C-allyl P=S-modified ribozyme described in Example 14, above. This ribozyme binds to a nucleotide long region of the c-myb mRNA. Thus, a nucleotide antisense phosphorothioate DNA molecule was prepared. A phosphorothioate DNA oligonucleotide with a randomly scrambled sequence of the same 15 nucleotides and a 2'-C-allyl P=S-modified ribozyme with randomly scrambled target binding arm sequences were synthesized as controls (by comparison to the murine c-myb cDNA sequence, the scrambled controls would not be expected to bind any region of the c-myb mRNA). Since longer phosphorothioate DNA oligonucleotides are often utilized as antisense inhibitors (for a review see Wagner, 1994 Science 372, 333), a symmetrically placed, 25 nucleotide phosphorothioate DNA antisense oligonucleotide and its scrambled sequence control were also synthesized. The ribozymes and the antisense oligonucleotides were delivered to rat smooth muscle cells as complexes with the cationic lipid, Lipofectamine, and serum-stimulated smooth muscle cell proliferation was measured subsequently.

As shown in Figure 11, the 2 -C-allyl P=S-modified 15 ribozyme demonstrated greater inhibition of smooth muscle cell proliferation than either of the antisense oligonucleotides. Furthermore, the scrambled arm ribozyme and S* inactive ribozyme controls demonstrated less non-specific inhibition than either of the scrambled sequence antisense 20 control oligonucleotides. In fact, the non-specific inhibition demonstrated by the 25 nucleotide phosphorothioate molecule completely masked any specific effect of the Santisense molecule. Similar results have been obtained with phosphorothioate DNA targeting other sites in the cmyb mRNA. Thus, a ribozyme that cleaves c-myb RNA is a more potent and more specific inhibitor of smooth muscle cell proliferation than phosphorothioate antisense DNA molecules.

Example 17: Chemically-modified ribozymes targeting different sites in the c-myb mRNA specifically inhibit smooth muscle cell proliferation.

If the observed inhibition of smooth muscle cell proliferation is mediated by ribozyme cleavage of c-myb mRNA, then other ribozymes that target the same mRNA should have the same effect. Two other ribozymes targeting two disparate sites in the c-myb mRNA (sites 549 and 1553, ribozyme Seq. ID Nos. 102 and 112) were synthesized with the 2 -C-allyl P=S modifications as described in Example 14. Inactive ribozyme controls also were synthesized corresponding to each new target sequence.

Chemically-modified ribozymes targeting sites 549, 575, and 1553 were delivered to rat smooth muscle cells and their ability to inhibit serum-stimulated cell proliferation was assessed. Equivalent levels of inhibition are obtained with active ribozymes targeting sites 549, 575 and 1553 (see Figure 12). None of the inactive ribozymes inhibited cell proliferation. Active ribozymes targeting other mRNA sequences not present in cmyb or ribozymes with scrambled arm sequences also fail to inhibit smooth muscle cell proliferation (see Figure 12) 15 Thus, inhibition of cell proliferation requires a catalytically active ribozyme that can bind to accessible c-myb mRNA sequences and is likely due to the reduction of c-myb mRNA levels by ribozyme cleavage.

Examples 18 and 19 describe experiments designed to 20 determine the position and minimum number of phosphorothioate residues required for efficacy.

S•Example 18: Effect of position of phosphorothioate linkages on ribozyme inhibition.

Ribozymes targeting c-myb site 575 were synthesized with the 2"-C-allyl modification and with phosphorothioate linkages between various nucleotides in the ribozyme. One ribozyme contained a total of 10 phosphorothioate linkages, 5 in Stem I and 5 in Stem III, identical co the ribozyme described in Examples 14 through 17 above (referred to as 10 P=S 5' and 3' in Figure 13A). One ribozyme contained only 5 phosphorothioate linkages in Stem III (5 P=S 3' in Figure 13A). Another ribozyme contained 5 phosphorothioate linkages between the 6 nucleotides comprising the last base pair of stem II and the GAAA loop (5 P=S loop in Figure 13A). The fourth ribozyme contained 5 phosphorothioate linkages in stem I P=S 5- in Figure 13A). The latter two ribozymes also were synthesized with the 3 thymidine at the 3' end to help protect the ribozyme from 3' exonucleases (Ortigao et al., 1992 Antisense Res. Development 2, 129; Seliger et al., Canadian Patent Application No. 2,106,819). The structure of these four different ribozymes is diagrammed in Figure 13A. Inactive ribozyme controls were synthesized for each individual ribozyme. The active and inactive ribozymes were applied to rat smooth muscle cells as RNA/Lipofectamine complexes and their effects on cell proliferation were measured.

Referring to Figure 13B, the ribozyme containing phosphorothioate linkages in Stem I and the 3' inverted thymidine inhibited smooth muscle cell proliferation as 15 well as the parent ribozyme with 10 total phosphorothioate linkages. None of the other ribozymes demonstrated significant differences between active and inactive controls. Therefore, the 3' inverted T can effectively substitute for the 5 phosphorothioate linkages in Stem 20 III. Phosphorothioate linkages in the loop position lead to non-specific inhibition of smooth muscle cell proliferation, while phosphorothioate linkages in Stem I are necessary for enhanced efficacy in cells. Additionally, these results suggest that 3'-end modifications, such as iT, is desirable to minimize the amount of phosphorothioate contained in the ribozymes in order to minimize toxicity and facilitate chemical synthesis, while maintaining protection from endogenous 3'-exonuclease digestion.

Example 19: Minimizing phosphorothioate linkages in Stem I.

Fewer phosphorothioate linkages in the ribozyme will reduce the complexity and cost of chemical synthesis.

Furthermore, phosphorothioate DNA molecules are known to have some undesirable and non-specific effects on cellular functions (for a review see Wagner, supra) reducing the phosphorothioate linkages in these RNA molecules is expected to enhance their specificity. A series of ribozymes targeting c-myb were synthesized to determine how many phosphorothioate linkages in Stem I are required for optimal ribozyme activity. The ribozymes contained 5, 4, 3, 2, or 1 phosphorothioate linkage(s) in Stem I, beginning with the phosphodiester bond between the first and second nucleotides and proceeding Each ribozyme contained the 2"-O-methyl modifications, the U 4 2--C-allyl nucleotide, and the inverted T nucleotide at the 3' end as described above. Activity of each of these ribozymes was compared to the activity of the ribozyme with phosphorothioate linkages, 5 each in Stems I and III (referred to as 10 P=S in Figure 14). Active and inactive 15 ribozymes were applied to rat smooth muscle cells as complexes with Lipofectamine and their effects on smooth muscle cell proliferation were measured in two separate experiments. The results are diagrammed in Figure 14.

Ribozymes with 10, 5, and 4 phosphorothioate linkages 20 showed equivalent efficacy. Ribozymes with fewer than •o four phosphorothioate linkages also showed efficacy, but the level of inhibition of smooth muscle cell proliferation was modestly reduced.

Example 20: Varying the length of Stems I and III Ribozymes that cleave c-myb RNA at position 575 were synthesized with varying arm lengths. Each ribozyme contained 4 phosphorothioate linkages at the 5" end, methyl and 2'-C-allyl modifications and an inverted thymidine nucleotide at the 3' end as described above.

Figure 15 shows the effects of these ribozymes upon rat smooth muscle cell proliferation. Ribozymes were delivered at 100 nM with cationic lipid. Ribozymes with 6/6, 7/7 and 5/10 arms (where x/y denotes the nucleotides in Stem I/nucleotides in Stem III; see Figure 2) all showed comparable efficacy. As shown in Figure 15, ribozymes with longer arm lengths tended to demonstrate more nonspecific inhibition (the inactive ribozyme controls with longer binding arms inhibited smooth muscle cell proliferation) when compared to ribozymes with shorter binding arms. From these data, it appears that ribozymes with 6/6, 7/7, 5/10, 10/5, 8/8 and 10/10 nucleotide arms all specifically inhibit smooth muscle cell proliferation, optimal inhibition, however, is observed with 6/6, 7/7 and 5/10 nucleotide arms.

Example 21: Ribozymes with different modified nucleotides inhibit smooth muscle cell proliferation.

Ribozymes containing seven nucleotides in both Stems I and III, four phosphorothioate residues at the 5' end and a 3'-3 inverted thymidine at the 3 end, were synthesized with various modified nucleotides at the U 4 and U, positions within the core of a HH ribozyme. All of the modified catalytic core chemistries retained ribozyme activity and demonstrated enhanced stability to serum nucleases (Usman et al., 1994 supra). The ribozyme termed 20 U4 2'-C-allyl contains a 2'-C-allyl uridine at the U 4 position and a 2'-O-methyl nucleotide at the U 7 position.

The ribozyme termed U4,U7 2"-amino contains a 2'-amino nucleotide at both U4 and U7. The ribozyme termed U4 2 fluoro contains a 2 -fluoro-modified nucleotide at U4 and 2"-O-methyl at U7. The ribozyme termed U4 6-methyl contains a 6-methyl uridine nucleotide at U4 and methyl at U7. The ribozyme termed U4 deoxyabasic contains a deoxyribose moeity and lacks a base at U4 (Beigelman et al., 1994 Bioorganic Med. Chem. Letters 4, 1715) and 2 O-methyl at U7. Active and inactive versions of each of the chemically-modified ribozymes were applied to rat smooth muscle cells using Lipofectamine as described above. As diagrammed in Figure 16, all of the nucleasestable, chemically-modified ribozymes demonstrated significant inhibition of rat smooth muscle cell proliferation.

Thus, the requirements for ribozyme activity in smooth muscle cells appear to be a catalytically core that is modified to minimize endonucleolytic degradation and modifications at the 5' and 3' ends which may prevent exonucleolytic degradation.

Chemical modifications described in this invention are meant to be non-limiting examples, and those skilled in the art will recognize that other modifications (base, sugar and phosphate modifications) to enhance nuclease stability of a ribozyme can be readily generated using standard techniques and are hence within the scope of this invention.

Example 22: Ribozyme inhibition of pig smooth muscle cell proliferation.

Of the commonly used animal models of intimal hyper- 15 plasia after balloon angioplasty, the pig model is believed to be most predictive of human disease (Steele et al., 1985 Circ. Res. 57, 105; Ohno et al., 1994 Science 265, 781; Baringa, 1994 Science 265, 738). Therefore, we wished to assess the ability of c-myb ribozymes to inhibit 20 pig smooth muscle cell proliferation. Yucatan pig smooth muscle cells (YSM) were obtained from Dr. Elizabeth Nabel (University of Michigan Medical Center) and were grown in Dulbecco's modified Eagle's medium as described (see Example The YSM cells were starved for 72 hours in DMEM with 0.1% FBS. Active and inactive ribozymes (four phosphorothioate linkages at the 5' end, 2"-C-allylmodified core and inverted thymidine at the 3' end) were applied as RNA/Lipofectamine complexes as described in the above examples. Proliferation was stimulated with serum and assessed by BrdU incorporation. Figure 17 shows that a ribozyme dose of as low as 75 nM can inhibit pig smooth muscle cell proliferation by as much as 60%. The same chemical modifications of the ribozymes (2'-modified, stable core, 5' phosphorothioate linkages and 3' inverted thymidine) are required to obtain significant and reproducible inhibition of pig smooth muscle cell proliferation as were shown to be required for inhibition of rat cells in the above Examples.

Example 23: Ribozyme inhibition of human smooth muscle cell proliferation.

In Example 12, we demonstrated that a minimally modified ribozyme directed against c-myb site 549 could significantly inhibit human smooth muscle cell proliferation. The 2'-C-allyl and phosphorothioate-modified ribozyme targeting c-myb site 575 characterized above was applied to human smooth muscle cells as RNA/Lipofectamine complexes. Inactive ribozyme and inactive, scrambled arm ribozymes were applied as controls. At 200 nM, the active ribozyme inhibits human smooth muscle proliferation by 15 greater than 75% while the inactive ribozyme inhibits proliferation by only 38%. The ribozyme with scrambled binding arm sequences fails to inhibit. At 100 nM, the Sactive ribozyme still demonstrates significant inhibition while neither the inactive or scramble controls inhibit 20 cell proliferation (see Figure 18) Thus, the active ribozyme identified in these studies mediates significant inhibition of human smooth muscle cell proliferation and represents a novel therapeutic for restenosis and/or vascular disease.

Example 24: Delivery of c-myb ribozymes to vessels in vivo.

The ribozyme that cleaves c-myb RNA at site 575 was synthesized in two parts (Mamone, supra), the internal end was labeled with 33P using polynucleotide kinase and the two fragments were ligated with RNA ligase. The resulting RNA was an intact ribozyme with an internal 33

P

label. This internally-labeled ribozyme was delivered to balloon injured rat carotid arteries as described (Simons et al., 1992 Nature 359, 67). Rats were anesthetized and the carotid artery was surgically exposed. The external carotid was dissected and a 2F Fogarty balloon catheter was inserted and directed into the carotid artery. Injury was caused by repeated (3 times) inflation and retraction of the balloon. The injured region was isolated by ligatures and a cannula was inserted in the external carotid. Ribozymes alone (two rat vessels) or ribozyme/Lipofectamine complexes (two rat vessels) were applied to the injured vessel through the cannula and were left in the vessel for twenty minutes. After application, blood flow was restored by removal of the ligatures for five minutes and the vessels were harvested and processed as described below.

Half of the vessel was frozen in liquid nitrogen, crushed into a fine powder, and RNA was extracted using standard protocols. The extracted RNA was applied to a 15 denaturing polyacrylamide gels and subjected to electrophoresis. Autoradiography of the gel permitted detection of the 33 P label; the amount of radioactivity in each band was quantitated using a Phosphor-imaging system.

The amount of extracted and intact ribozyme was calculated 20 by direct comparison to labeled ribozyme controls run on the same gel. The percentage of the ribozyme delivered intact could be estimated by quantifying the percentage of label that co-migrates with the intact ribozyme controls.

After delivery of ribozymes in phosphate-buffered saline (PBS) 3% of the 33 P label was recovered from the rat vessels and >90% of the label was present in the form of intact ribozyme. After delivery of ribozyme in RNA/Lipofectamine complexes, 10 to 11% of the 33 P label was recovered from the rat vessels and 20 to 90% of the label was present in the form of intact ribozyme. The significant uptake of the intact ribozyme demonstrates that local delivery of modified ribozymes to arterial walls is feasible.

The other half of each vessel was fixed in PBSbuffered 2% glutaraldehyde, sectioned onto slides and coated with emulsion. After autoradiography for four days, the emulsion was developed and the sections were stained with hematoxylin and eosin by standard techniques (Simons et al., 1992 supra). Inspection of the sections showed a majority of the grains present over the medial smooth muscle cells after application of the ribozyme.

Some 33 P label could be detected in the underlying adventitia as well. Similar density and distribution of grains was observed when the ribozyme was delivered with or without Lipofectamine. These data demonstrate that ribozyme can penetrate the injured vessel wall and is in close apposition or within the underlying medial smooth muscle cells. Thus, therapeutic ribozymes can be locally delivered to vessels for the treatment of vascular disease.

Similar experiments were performed in pig iliofemoral vessels. After balloon injury, a ribozyme, internally 15 labeled with 33 P as described above, was delivered with a double balloon catheter device (Nabel and Nabel, supra; Ohno et al., 1994 supra). After 20 minutes, blood flow was restored by deflating the balloons. The vessels were harvested after an additional hour or the surgical 20 injuries were sutured and the vessels harvested one day later. Harvested vessels were sectioned, subjected to autoradiography and stained. One hour after delivery, the majority of the 33 P label could be detected in the media, overlying or within smooth muscle cells. Some label was also detected at the luminal surface of the vessel and in the adventitial tissue. One day after delivery, grains could be still be detected associated with remaining medial smooth muscle cells. No major differences in density or distribution was observed between ribozymes delivered with or without Lipofectamine®. These data demonstrate that ribozymes can be locally delivered to smooth muscle cells of injured vessels in a large animal model that is clinically relevant to human vascular disease.

Example 25: Ribozyme-mediated decrease in the level of cmvb RNA in rat smooth muscle cells.

To determine whether a ribozyme catalyzes the cleavage of c-myb RNA in a mammalian cell, applicant has used a sensitive quantitative competitive polymerase chain reaction (QCPCR) to assay the level of c-myb RNA in rat smooth muscle cells treated with either catalytically active or inactive ribozyme.

Rat smooth muscle cells (RASMC) were treated with ribozymes as described above. Following the ribozyme treatment for 4h, cells were stimulated with 10% serum (in the presence or absence of BrdU). After 24h, cells were harvested for further analysis. Cells, that were treated with BrdU, were assayed for proliferation as described S* 15 above. Cells, that were not treated with BrdU, were used for the QCPCR assay.

S" The following is a brief description of the QCPCR technique used to quantitate levels of c-myb mRNA from RASMC, normalizing to the housekeeping gene, GAPDH. This 20 method was adapted from Thompson et al, Blood 79:1692, 1992. Briefly, total RNA was isolated from RASMC using the Guanidinium isothiocyanate technique of Chomczynski and Sacchi (Analytical Biochemistry, 162:156, 1987). In order to construct a deletion competitor and control wildtype RNA, a cDNA clone of the rat c-myb message, referred to as pc8myb, was used. The competitor RNA comprises a deletion of 50 bases, making it smaller than the wild-type cellular RNA, and spansfrom nucleotide 428 to nucleotide 753.

A house-keeping gene, GAPDH, that is constitutively expressed by the RASMC, was used as an internal control for QCPCR assay. A deletion competitor and wild-type controls for GAPDH were made the same way as for c-myb.

GAPDH-containing plasmid (pTri-GAPDH) was purchased from Ambion. The GAPDH competitor is also a deletion mutant, lacking 50 bases. The GAPDH competitor was used to quantitate the amount of this housekeeping gene in each sample, thus allowing for a confirmation of cellular RNA's integrity and for the efficiency of RNA isolation. All quantitations for the level ofc-myb expression were normalized to the level of GAPDH expression in the same sample of cells.

Referring to Fig. 19, RASMC that were treated with a stabilized catalytically active 575 HH ribozyme did not proliferate well. There was greater than 70 inhibition of RASMC proliferation when compared with approximately 25% inhibition of cell proliferation by a catalytically inactive version of the 575 HH ribozyme. The level of inhibition of RASMC proliferation correlates very well with the greater than 70 decrease in the level of c-myb RNA. This shows that the inhibition of smooth muscle cell 15 proliferation is directly mediated by the cleavage of cmyb RNA by a ribozyme in RASMC.

"Figure 20 shows what Applicant presently believes is an optimal ribozyme configuration.

20 Example 26: Inhibition of smooth muscle cell proliferation by 2-5A antisense chimera.

By "2-5A antisense chimera" is meant, an antisense oligonucleotide containing a 5' phosphorylated linked adenylate residues. These chimeras bind to target RNA in a sequence-specific manner and activate a cellular ribonuclease which in turn cleaves the target RNA (Torrence et al., 1993 Proc. Natl. Acad. Sci.

USA 90, 1300).

RNAs containing Adenosine with a terminal phosphate has been shown to activate RNAse L (Torrence et al., 1993 Proc. Natl. Acad. Sci. USA 90, 1300). The terminal phosphate is required for efficient activation of RNAse L. Ribozymes targeting c-myb site 575 were synthesized with 2-5A moieties on the 5' end, with and without the terminal 5' phosphate. The chimera was complexed with LipofectAMINE and assayed on rat aortic smooth muscle cells (RASMC) as described above.

As shown in Figure 21, when no terminal phosphate is present, the active ribozyme [575 inactive Rz+ inactive functions similarly to a normal active ribozyme lacking a 2-5A modification (575 active Rz). An inactive ribozyme core with 5' phosphate-2-5A [575 inactive Rz+ active P(A)4] shows significant inhibition relative to the controls, but has significantly lower activity when compared with an active ribozyme. A molecule that contains both an active ribozyme core and 5' phosphatecontining 2-5A [575 active Rz+active P shows even greater inhibition than that obtained by either mechanism individually, inhibiting the smooth muscle cell prolifera- 'o tion to baseline levels FBS). Thus the ribozyme and 2-5A anitisense chimera together show an additive effect 15 in inhibiting RASMC proliferation.

Use of Ribozvmes That Cleave c-myb RNA to Treat Restenosis.

The above discussion demonstrates, by way of example, 20 how ribozymes that inhibit smooth muscle cell proliferation are delivered directly, or through the use of expression vectors, to vessels. Preferably, ribozymes cleaving c-myb RNA are delivered to vessels at the time of coronary angioplasty. Local delivery during intervention can be achieved through the use of double balloon catheters porous balloon catheters balloon catheters coated with polymers (Riessen, et al., 1993, Human Gene Therapy, 4, 749-758), or biopolymer stents (Slepian and Schindler, U.S. Patent 5,213,580). In the above examples, ribozymes were identified that could inhibit roughly half of the smooth muscle cells in culture from proliferating in response to the growth factors present in serum. A corresponding 50% (or even lower) reduction in intimal thickening will significantly improve the outcome of patients undergoing coronary angioplasty.

Use of Ribozymes Targeting c-myb to Treat Cancer Overexpression of the c-myb oncogene has been reported in a number of cancers, including leukemias, neuroblastomas, and lung, colon, and breast carcinomas (Torelli, et al., 1987, Cancer Res., 47, 5266-5269; Slamon, D. et al., 1986, Science, 233, 203-206; Slamon, D. et al., 1984, Science, 224, 256-262; Thiele, C. et al., 1988, Mol. Cell. Biol., 8, 1677- 1683; Griffin, C. A. and Baylin, S. 1985, Cancer Res., 45, 272-275; Alitalo, et al., 1984, Proc. Natl.

Acad. Sci. USA, 81, 4534-4538). Thus, inhibition of c-myb expression can reduce cell proliferation of a number of e cancers. Indeed, in tissue culture, treatment of colon adenocarcinoma, neurectodermal, and myeloid leukemia cell S* 15 lines with antisense c-myb oligonucleotides inhibits their proliferation (Melani, et al., 1991, Cancer Res., 51, 2897-2901; Raschella, et al., 1992, Cancer Res., 52, S" 4221-4226; Anfossi, et al., 1989, Proc. Natl. Acad.

Sci. USA, 86, 3379-3383). Furthermore, myeloid cells from 20 patients with chronic myelogenous leukemia and acute myelogenous leukemia are differentially sensitive to c-myb antisense oligonucleotides (Calabretta, et al., 1991, Proc. Natl. Acad. Sci. USA, 88, 2351-2355). Ratajczak, et al. (1992, Proc. Natl. Acad. Sci. USA, 89, 11823-11827) treated mice bearing human leukemia cells with c-myb antisense oligonucleotides and significantly prolonged their survival and reduced their tumor burden. Thus, reduction of c-myb expression in leukemic cells in tissue culture and in vivo can reduce their proliferative potential.

While the above studies demonstrated that antisense oligonucleotides can efficiently reduce the expression of c-myb in cancer cells and reduce their ability to proliferate and spread, this invention describes enzymatic RNAs, or ribozymes, shown to cleave c-myb RNA. Such ribozymes, with their catalytic activity and increased site specificity (see above), are likely to represent more potent and safe therapeutic molecules than antisense oligonucleotides for the treatment of cancer as well as restenosis. In the present invention, ribozymes are shown to inhibit smooth muscle cell proliferation. From those practiced in the art, it is clear from the examples described, that the same ribozymes may be delivered in a similar fashion to cancer cells to block their proliferation.

In a preferred embodiment, autologous bone marrow from patients suffering with acute myelogenous leukemia or chronic myelogenous leukemia are treated with ribozymes that cleave c-myb RNA. Ribozymes will be delivered to the autologous bone marrow cells ex vivo at 0.1 to 50 AM with or without forming complexes of the ribozymes with 15 cationic lipids, encapsulating in liposomes or alternative delivery agents. After several days, the proliferative capacity of the leukemic cells in the patients bone marrow e* will be reduced. The patient's endogenous bone marrow cells will be depleted by chemical or radiation treatments and their bone marrow reconstituted with the ex vivo treated cells. In such autologous bone marrow reconstitution treatments of leukemic patients, recurrence of the disease can be caused by proliferation of leukemic cells present in the transplanted bone marrow. Significantly reducing the proliferative potential of the leukemic cells by treating with ribozymes that cleave c-myb RNA will reduce the risk of recurrent leukemia.

Diagnostic uses Ribozymes of this invention may be used as diagnostic tools to examine genetic drift and mutations within diseased cells or to detect the presence of c-myb RNA in a cell. The close relationship between ribozyme activity and the structure of the target RNA allows the detection of mutations in any region of the molecule which alters the base-pairing and three-dimensional structure of the target RNA. By using multiple ribozymes described in this invention, one may map nucleotide changes which are important to RNA structure and function in vitro, as well as in cells and tissues. Cleavage of target RNAs with ribozymes may be used to inhibit gene expression and define the role (essentially) of specified gene products in the progression of disease. In this manner, other genetic targets may be defined as important mediators of the disease. These experiments will lead to better treatment of the disease progression by affording the possibility of combinational therapies multiple ribozymes targeted to different genes, ribozymes coupled .r with known small molecule inhibitors, or intermittent *fees: t treatment with combinations of ribozymes and/or other chemical or biological molecules). Other in vitro uses of ribozymes of this invention are well known in the art, and include detection of the presence of mRNAs associated with c-myb_related condition. Such RNA is detected by S" determining the presence of a cleavage product after treatment with a ribozyme using standard methodology.

20 In a specific example, ribozymes which can cleave only wild-type or mutant forms of the target RNA are used for the assay. The first ribozyme is used to identify wild-type RNA present in the sample and the second ribozyme will be used to identify mutant RNA in the sample. As reaction controls, synthetic substrates of both wild-type and mutant RNA will be cleaved by both ribozymes to demonstrate the relative ribozyme efficiencies in the reactions and the absence of cleavage of the "non-targeted" RNA species. The cleavage products from the synthetic substrates will also serve to generate size markers for the analysis of wild-type and mutant RNAs in the sample population. Thus each analysis will require two ribozymes, two substrates and one unknown sample which will be combined into six reactions. The presence of cleavage products will be determined using an RNAse protection assay so that full-length and cleavage fragments of each RNA can be analyzed in one lane of a polyacrylamide gel. It is not absolutely required to quantify the results to gain insight into the expression of mutant RNAs and putative risk of the desired phenotypic changes in target cells. The expression of mRNA whose protein product is implicated in the development of the phenotype c-myb) is adequate to establish risk. If probes of comparable specific activity are used for both transcripts, then a qualitative comparison of RNA levels will be adequate and will decrease the cost of the initial diagnosis. Higher mutant form to wild-type ratios will be correlated with higher risk whether RNA levels are compared qualitatively or quantitatively.

Other embodiments are within the following claims.

*°*oo *o o Table I: Characteristics of Ribozymes Group I Introns Size: -200 to >1000 nucleotides Requires a U in the target sequence immediately 5' of the cleavage site Binds 4-6 nucleotides at 5' side of cleavage site.

Over 75 known members of this class. Found in Tetrahymena thermophila rRNA, fungal mitochondria, chloroplasts, phage T4, blue-gree algae, and others.

*RNAseP RNA (Ml RNA) Size: -290 to 400 nucleotides RNA portion of a ribonucleoprotein enzyme. Cleaves tRNA precursors to form mature tRNA.

15 Roughly 10 known members of this group are all bacterial in origin.

Hammerhead Ribozyme Size: -13 to 40 nucleotides.

S**e 20 Requires the target sequence UH immediately 5' of the cleavage site.

Binds a variable number nucleotides on both sides of the cleavage site.

14 known members of this class. Found in a number of plant pathogens (virusoids) that use RNA as the infectious agent (Figure 1) Hairpin Ribozvme Size: -50 nucleotides.

Requires the target sequence GUC immediately 3' of the cleavage site.

Binds 4-6 nucleotides at 5' side of the cleavage site and a variable number to the 3' side of the cleavage site.

Only 3 known member of this class. Found in three plant pathogen (satellite RNAs of the tobacco ringspot virus, arabis mosaic virus and chicory yellow mottle virus) which uses RNA as the infectious agent (Figure 3).

Hepatitis Delta Virus (HDV) Ribozyme Size: 50-60 nucleotides (at present).

Cleavage of target RNAs recently demonstrated.

Sequence requirements not fully determined.

Binding sites and structural requirements not fully determined, although no sequences 5' of cleavage site are required.

Only 1 known member of this class. Found in human HDV (Figure 4).

Neurospora VS RNA Ribozyme Size: -144 nucleotides (at present) Cleavage of target RNAs recently demonstrated.

Sequence requirements not fully determined.

Binding sites and structural requirements not fully determined. Only 1 known member of this class. Found in Neurospora VS RNA (Figure Table II: Ribozvme catalyzed cleavage of c-mvb RNA Hammerhead Sites Cleavage Site 310 549 551 575 634 738 839 936 1017 1082 1363 1553 1597 1598 Sequence ID No.

79 80 81 82 83 84 85 86 87 88 89 90 91 92 Target Sequence

CGUCACU

GUCUGUU

CUGUUAU

GGAGAAU

AAAACCU

UAAUGCU

CAAGCUU

UUCCUAU

UGUCCCU

AGCGAAU

UUAGAAU

CAGCUAU

ACACCAU

CACCAUU

U GGGGAAA A UUGCCAA U GCCAAGC U GGAAAAC C CUGGACA A UCAAGAA C CAGAAGA U ACCACAU C AGCCAGC A AAGGAAU U UGCAGAA C AAAAGGU U CAAACAU C AAACAUG Cleavage Mouse Human c-myb c-myb RNA RNA 28.5 0.1 87.4 91.6 56.8 82.4 93.9 91.3 68.4 87.1 78.1 0.01 27.2 0.01 61.8 60.6 40.3 0.1 55.2 89.2 11.6 0.1 87.1 92.5 71.2 62.7 79.6 85.5 Hammerhead Sites Cleavage Sequence Site ID No.

1635 1721 1724 1895 1909 1943 Target Sequence AUACGGU C CCCUGAA CUGGAAU U GUIJCUG GAAUUGU U GCUGAGU AUAUUCU U ACAAGCU UCCGUUU U AAUGGCA ACAAUGU U CUCAAAG Cleavage Mouse Human c-mvb c-myb RNA RNA 84.4 82.3 62.1 79.3 65.6 86 79.1 66.2 31.1 0.1 66.1 Hairpin Ribozymes 1632 10 2231 ACG GUCC CCUGAAG ACA GUUG AGAGCAG 92.8 0.1 84 .6 0.1 100 a The nucleotide numbers given correspond to the nucleotide just 5' of the ribozyre cleavage site in the human c-myb sequence taken from Westin, et al., supra (GenBank 15 Accession No. X52125) All but two of the sequences (310; I.D. No. 79 and 2231; I. D. No. 100) overlap sequences in Table I.

Table III: Sequences of ribozymes used in these studies.

Target Sequence Ribozyme Sequence Site ID No.

Hammerhead ribozvmes with 7 nuicle otide binding arms 310 549 551 575 634 738 839 936 1017 1082 1363 101 102 103 104 105 106 107 108 109 110 111 UUTUC CCCCUGAUGAGG CCGAAAGGCCGAAAGUGACG

TUGGCAACUGAUGAGGCCGAAAGGCCGAJAACAGAC

GCUTGGCCUGAUGAGGCCGAAAGGCCGAAAUAACAG

GCUUUCCCUGAUGAGGCCGAAAGGCCGAAAUUCUCC

UGUCCAGCUGAUGAGGCCGAAAGGCCGAAAGGUUUUT

UUCUUGACUGAUGAGGCCGAAAGGC CGAAAGCAUUA

UCUUCUGCUGAUGAGGCCGAAAGGCCGAAAAGCUCG

AUGUGGUCUGAUGAGGCCGAAAGGCCGAAAUAGGAA

GCCGGCUCUGAUGAGCGCGAAAGCGCGAAAGGGACG

GCUCC UCUGAUGAGGCCGAAAGGCCGAAAUUCGCU

UUCUGCACUGAUGAGGCCGAAAGGCCGAAAUUCUAA

1553 1597 1598 1635 1721 1724 1895 1909 1943 112 113 114 115 116 117 118 119 120 ACCUITJCUGAUGAGG CCGAAAGGC CGAAAUAGCUG AUGUTJUGCUGAUGAGGCCGAAAGG CCGAAAUGGUGU CAUGUTJCUGAUGAGG CCGAAAGG CCGAAnAAUGGUG

TUCAGGGCUGAUGAGGCCCGAAAGGCCGAAACCGUAU

CAGCAACCUGAUGAGGCCGAAAGG CCGAAAUUCCAG ACUCAGCCUCAUGAGG CCGAAAGC CCGAAACAAUUC AGCUTJGUCUGAUGAGG CCGAAAGG CCGAAAGAAUAU UGUCAUUCUGAUGAGG CCGAAAGG CCGAAAAACAGA CUIJUGAGCUGAUGAGG C CAAAGG CCGAAACAUUGU Bimolecular Hairpin Ribozvmes 1 6 3 2 a 121 5' Fragment: UCAGCGAGAAGUAUAC CAGAGAAACACACG CG 3' Fragment: CGCGUGGUACAUTJACCUGGUA 2 2 3 1 a 122 5' Fragment:

GCUCUCAGAAGUUGACCAGAGAAACACACGCG

3' Fragment: CGCGUGGUACAUUACCUGGUA Hammerhead riboyzmes with 6, 8, 9, 10, and 12 nucleotide binding arms 575 575 8/8 575 20 9/9 575 i0/ic 575 12/12 549 12/12 123 124 125 126 127 128 129 CUUUCCCUGAUGACGCCGAA-AGGCCGAA AIJTCUC UGCUUTJCCCUGAUGAGGCCGAAAGG CCGAA

ATJUCUCCC

CUGCUUUCCCUGAUGAGGCCGAAAGGC CGAA

AUTJCTCCCU

ACUGCIJ=UCCCUGAUGAGGCCGAAAGGCCGAA

AUUCUCCCUU

ACACUGCUUC CCUGAUGAGGC CGAAAGGC CGAA

AUUCUCCCUUTJ

AGUGCUUGGCAACUGAUGAGGC CGAAAGG C GAA

AACAGACCAACG

GAUUGACCUTJUUCUGAUGAGGC CGAAAGGC CGAA

AUAGCUGGAGUU

ribozymes were synthesized in two pieces as 1553 12/12 aThe hairpin indicated. The two ol igonucleot ides* were annealed and tested for activity against the c-myb RNA as described above. See Mamone, Ribozyme synthesis, filed May 11, 1992, U.S.S.N. 07/882,689, hereby incorporated by reference herein.

bDesignation of the ribozymes with different arm lengths is a/b where represents the nucleotides in stem I and represents the nucleotides in stem III (see Figure 1) Table IV: Comparison of the effects six hamm rhparl ribozymes, that cleave c-mvb RNA, on smooth muscle cell 9 9* 9 9 9.

9 proliferation Inactive Active Inhibition Ribozyme Ribozyme Ribozyme Cell Cell (Active vs.

Site Proliferation Proliferation Inactive) 549 68 1 59.5 1.5 14 4 575 66.5 0.5 54.5 1.5 21 3 1553 68.5 0.5 52 1 28 1 1597 66 1 57 3 16 7 1598 67 1 58.5 0.5 15 1 1635 62.5 2.5 64 1 0 Table V: Dose Response of c-myb Hairpin Ribozyme 1632 Control Ribozyme 1632 Ribozyme Ribozyme Inhibition Dose (4M) Proliferation Proliferation (vs. control) 0.05 86.5 1.5 88 5 0 0.15 89.5 1.5 78.5 2.5 10 0.45 87.5 1 66.5 1.5 25 4 6 Table VI: Dose Response of c-mvb Hammerhead Ribozymes 575 and 549 Control Ribozyme 575 Ribozyme 549 R ibo zyme Ribo- %cells %cells %cells 0 zyme in S in S Inhibi- in S Inhi-bi- Dose phase phase tion phase tion (vs. (vs.

con- control) trol) 0.05 89+5 77.5+1.5 14+8 92+1 0 0.15 90+1 68.5+1.5 26+2 84+2 9+4 0.45 91.5+0.5 59+5 38+7 76.5+2.5 18+5 Table VII: Delivery of c-mvb Ribozyme 575 by Two Different Cationic Lipids Delivery with DMRIE/DOPE Inactive Active Ribozyne 575 Ribozyme 575 Ribozyme %cells in S %cells in S %Inhibition Dose (iiM) phase phase (vs. inactive) 0. 075 79 6 74.5 1.5 6 6 0.15 79.5 0.5 67 1 17 4 0.30 77±+1 57±+2 28+ Delivery with Lipofectamine Inactive Active Ribozymne 575 Ribozyme 575 Ribozyme %cells in S %cells in S %Inhibition Dose (AM) phase phase (vs. inactive) 0.075 81 1 83 0.15 79 +3 71+ 11+ 4 0.30 82 1 68.5 1.5 18 4 0.60 75 1 59.5 3.5 22 7 a. a a a a a Table VIII: Arm Lenath Variations of c-myhF~mphpr Ribozyme 575 Arm Length (base cells in S Inhibition (vs.

pairs) phase Inactive 7/7) 6/6 62 1 4 4 7/7 60 1 7 3 8/8 60.5 0.5 6 2 9/9 53.5 0.5 18 2 10/10 55 1 16 4 12/12 48 1 28 3 Table IX: Hammerhead ribozvmes with 7 vs. 12-nucleotide binding arms targeting three different sites Ribozyme Length of Inactive Active Target Binding Ribozyme Ribozyme Inhibition Site Arms Cell Cell (Active Prolifera- Prolifera- vs.

tion) tion) Inactive) 575 7/7 51.5 0.5 43 0.5 24 575 12/12 50.5 3.5 37 0.5 37 4 549 7/7 49.5 0.5 44.5 1.5 21 7 549 12/12 48.5 1.5 35 2 41 7 1553 7/7 49.5 0.5 43.5 2.5 23 9 1553 12/12 49 1 33.5 1.5 45 6 Table X: Effect of chlorocuine on ribozyme inhibition of smooth muscle cell proliferation Ribozyme Chloro- Inactive Active Inhibiquine Ribozyme Ribozyme tion (tM) Cell Cell (Active Prolifera- Prolifera- vs.

tion) tion) inactive) 575, 12/12 0 81.8 0.5 74 1 10 2 575, 12/12 10 83 4 62.5 0.5 28 6 Tmhik-% YTa T""hi t- jr-,r n-f Wiilmn Aortic qmnh H I r I I

S

S

S

15 by c-mvb Ribozyre 549 Inactive Active Inhibition Ribozyme Ribozyme Ribozyme Prolifera- Prolifera- (active vs.

Dose (jiM) tion tion inactive) 0.075 55 2 40.5 4.5 30 13 0.15 53 10 42 1 23 23 0.30 53 7 32.5 4.5 44 22 Table XII: Inhibition of Rat Smooth Muscle Cell Proliferation by Direct Addition of a Chemically-Modified c-myb Ribozyme 575 Inactive Active Inhibition Ribozyme Ribozyme Ribozyme Prolifera- Prolifera- (active vs.

Dose (AM) tion tion inactive) 0.22 42 3 36 0.5 15 8 0.67 48 3 35 +t 2 28 9 52 5 25 1 54 7 Table XIII: Human c-myb Hairpin Ribozyme and Target Sequences Posi- Ribozyme Sequence Target tion 104 CCCUCCCC AGAA GCGC GCGCA GCC ACCAGAGAAACACACGUJGUGGUACAUUACCUGGUA GGGGAGGG 148 ACCGACCG AGAA GCCG CGGCA GCC ACCAGAGAAACACACGUUGUGGUACAUTJACCUGGUA CGGUCGGU 185 GCGCGGCG AGAA GCGG CCGCC GCC ACCAGAGAAACACACGUUGUCGUACAUUACCUCGUA CCCCGCGC 528 ACGUUUCG AGAA GUAU AUACG GUC ACCAGAGAAACACACGUUGUGGUACAUTACCUGGUA CGAAACGU

S

Posi- Ribozyme Sequence Target tion 715 UUCGUCCA AGAA GTJAG CUACU GCC ACCAGAGAAACACACGUUGUGGUACAUUAC CUGGUA UGGACGAA 1025 AUGGCUGC AGAA GCUG CAGCU GCC ACCAGAGAAACACACGUTJGUGGUACAUUACCUGGUA GCACCCAU 1187 CUGGUGUG AGAA GCAA TUUGCC GAC ACCAGAGAAACACACGUUGUGGUACATJUACCUGGUA CACACCAG 1532 GUUCUAAA AGAA GUAU AUACU GU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA

UUTJAGAAC

1632 CUTJCAGGG AGAA GUAU AUACG GUC ACCAGAGAAACACACGUUGUGGUACAJTJACCUGGUA

CCCUGAAG

1836 GGUAUUCA AGAA GUCC GGACA GUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA UGAAUAC C 1852 UCTJGCGUG AGAA GUTJG CAACU GTU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA

CACGCAGA

1861 CAGGCGAG AGAA GCGU ACGCA GAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA

CUCGCCUG

1993 UGCUACAA AGAA GCAA UUGCA GCC ACCAGAGAAACACACGUJGUGGUACATJUACCUGGUA, tUGUAGCA 2231 CUGCUCUC AGAA GUTJG CAACA GUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA GAGAG CAG 2316 UUAGGUAA AGAA GUUA UAACA GUC ACCAGAGAAACACACGUJGUGGUACAUJTACCUGGUA

UTJACCUAA

3068 AATJUAUAA AGAA GUCA UGACU GUU ACCAGAGAAACACACGTJUGUGGUACAUUACCUGGUA

UITAUAAUU

3138 AUCCAUGC AGAA GtJUC GAACU GUU ACCAGAGAAACACACGUUGUGGUACAJTACCUGGUA GCAUGGAU 3199 GUUCUUAA AGAA GUGA UCACU GCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA UUAAGAAC 3264 UGCUACAA AGAA GUAA UUACU GCC ACCAGAGAAACACACGUEJGUGGUACAUUTACCUGGUA

UUGUAGCA

Table XTV: Human c-mvb Hammerhead Ribozyme and Target Seq~uence nt. Target Sequence Ribozyme Sequence

C

C

C

C.

C

Posi tion 14 16 19 22 25 28 29 31 15 34 37 49 S2 55 58 60 61 62 25 64 76 156 160 170 172 224 226 228 253 254 274 287 288

CAACCUGU

AACCUGTU

ACCUGUU

UGTUUC CU U-UccCU

CUCCUCCU

cUCCUCCU UcCcCUU CUcCUUcU cu-UCUCcU

CUCCUCCU

CUccUCCU

CGUGACCU

GACCUCCU

CUCCUCCU

cucCcCU

CCUCCUCU

CUCCUCLU

UcUCUUU ccUUU.cU

GAGAAACU

AGAAACU

AGCCCGGU

CGGUCGGU

CCGCGGCU

GCGGCUCU

CACAGCAU

CAGCAUAU

0 CAUAUAU

UGAGGACU

GAGGACUU

CCAUGACU

GGGCUGCU

GGCUGCUU

UCCUCCUC

ccUcucc cUcUCCU

CUCCUCCU

cucCUUCU cUUCUccU CUCCUCcU

UCCUCCUC

CUCCUCCU

CUCCUCCG

CUCCGUGA

CGUGACCU

CUCCUCCU

CUCCUCUU

CUCUTJucu UTJUCU :cu

UCUCCUGA

CUCCUGAG

UCCUGAGA

CUGAGAAA

CGCCCCAG

GCCCCAGC

GGUCCCC3

CCCGCGGC

UCGCGGAG

GCGGAGCC

UAUAGCAG

UAGCAGUG

O CAGUGAC

UGAGAUGU

GAGAUGUG

UGAUGGGC

CCCAAGUC

CCAAGUCU

GAGGAGGkA

GGAGGAGG

AGGAGGAG

AGGAGGAG

AGAAG GAG

AGGAGAAG

AGGAGGAG

GAGGAGGA

AGGAGGAG

CGGAGGAG

UCACGGAG

AGGUCACG

AGGAGGAG

AAGAGGAG

AGAAAGAG

AGGAGAAA

UCAGGAGA

CUCAGGAG

UCUCAGGA

UUUCUCAG

CUGGGGCG

GCUGGGGC

CGGGGACC

GCCGCGGG

CUCCGCGA

GGCUCCGC

CUGCUAUA

CACUGCUA

GUCACUGC

ACAUCUCA

CACAUCUC

GCCCAUCA

GACUTJGGG

AGACUUGG

*CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA ACAGGUTJG GAA AACAGGU GAA AAACAGGU GAA AGGAAACA GAA AGGAGGAA GAA AGGAGGAG GAA AGGAGGAG GAA A-AGGAGGA GAA AGAAGGAG GAA AGGAGAAG GAA AGGAGGAG GAA AGGAGGAG GAA AGGUCACG GAA AGGAGGUC GAA AGGAGGAG GAA AGGAGGAG GAA AGAGGAGG GAA AAGAGGAG GAA AAAGAGGA GAA AGAAAGAG GAA AGUUUCUC GAA AAGUUUCU GAA ACCGGSCU GAA ACCGACCG GAA AGCCGCGG GAA AGAGCCGC GAA AUGCUGUG GAA AUAUGCUG GAA AUAUAUGC GAA AGUCCUCA GAA AAGUCCUC GAA AGUCAUGG GAA AGCAGCCC GAA AAGCAGCC 9 nt.

Position 295 306 310 392 393 395 402 403 405 414 452 455 467 470 15 477 480 498 509 515 518 526 531 540 544 548 549 551 562 563 575 588 603 615 623 624 634 Target Sequence UCCCAAGU C UGGAALAGC GAAAGCGU C GCGUCACU T- UGGAAAGU 1C GGAAAGTJU 2) AAAGUJAU U UUGCCAAU U UGCCAAUU A CCAAUUAU

C

UCCCGAAU C CAGAAAGU A AAAGUACU A CCUGAGCU C GAGCUCAU C UCAAGGGU C AGGGUCCU U AAGAAGAU C AGAGUGAU A AUAGAGCU U GAGCUUGU A ACAGAA.AU A AAUACGGU C CGAAACGU U ACGUTJGGU C UGGUCTJGU U GGUCUGUU

A

UCUGUUAU U 2ACUUGGGG J GGGGAAAA

AUUGCCAA

UUGCCAAU

GCCAAUUA

AUCUCCCG

UCUCCCGA

UCCCGAAU

GAACAGAU

CUAAACCC

AACCCUGA

AUCAAGGG

AAGGGUCC

CUUGGACC

GGACCAAA

AGAGAGUG

GAGCUUGU

GUACAGAA

CAGAAAUA

CGGUCCGA

CGAAACGU

GGUCUGUTJ

UGUUAUUG

AUUGCCAA

TUGCCAAG

GCCAAGCA

C CUUUCCA

CCCCAAGU

UUUUCCCC

TJUGGCAAU

AUUGGCAA

UAAUUGGC

CGGGAGAU

UCGGGAGA

AUUCGGGA

AUCUGUJC

GGGUUJAG

UCAGGGU

CCCUUGAU

GGACCCUU

GGUCCAAG

UUUGGUCC

CACUCUCU

ACAAGCUC

TJUCUGUAC

UAUUUCUG

UCGGACCG

ACGUUUCG

AACAGACC

CAAUAACA

UTJGGCAAU

CUUGGCAA C UGCUUGGC C UcCcUTUu C CUCCCCUTJ C UGUTJIUCC C CCUCUCCc C CAAGUGGU C AACUUCUG C GUUTUCUU C GGUUUUCU C CUGUCCAG C CUGAUGA X GAA ACUUGGGA CUGAUGA X GAA ACGCUJUC CUGAUGA X GAA AGUGACGC CUGAUGA X GALA ACUUUCCA CUGAUGA X GAA AACUIUucc CUGAUGA X GAA AUAACUTU CUGAUGA X GALA AUUGGCAA CUGAUGA X GAA AAUUGGCA CUGAUGA X GAA AUAAUUGG CUGAUGA X GAA AUUCGGGA CUGAUGA X GAA ACUUUCUG CUGAUGA X GAA AGUACUJUU CUGAUGA X GAA AGCUCAGG CUGAUGA X GAA AUGAGCUC CUGAUGA X GAA ACCCUUGA CUGAUGA X GAA AGGACCCU CUGAUGA X GAA AUCUUCUU CUGAUGA X GAA AUCACUCU CUGAUGA X GAA AGCUCUAU CUGAUGA X GAA ACAAGCUC CUGAUGA X GAA AUUUCUGU -UGAUGA X GAA ACCGUAJUU 7UGAUGA X GAA ACGUTJUCG 'UGAUGA X GAA ACCAACGU :UGAUGA X GAA ACAGACCA UGAUGA X GAA AACAGACC 2UGAUGA X GAA AUAACAGA UGAUGA X GAA AGUGCUUG 2UGAUGA X GAA AAGUGC-U ~UGAUGA X GAA AUUCUCCC UGAUGA X GAA ACAUTJGUU ~UGAUGA X GALA AUGCCACC UGAUGA X GAA AUUCAAGU UGAUGA X GAA ACUUCUGG UGAUGA X GAA AACUUCUG 'UGATJGA X GAA AGGUUUUC Ribozyme Sequence CAAGCACU U AAAGGGGA AAGCACUU A AAGGGGAG GGGAGAAU U GGAAAACA AACAAUGU A GGGAGAGG GGUGGCAU A ACCACUUG ACUTJGAAU C CAGAAGUU CCAGAAGU U AAGAAAAC CAGAAGUU A AGAAAACC GAAAACCU C CUGGACAG a a a. a.

a a nt Position 659 660 662 663 664 704 713 732 738 740 756 757 759 768 15 776 789 790 792 802 804 805 838 839 852 855 856 864 865 866 870 876 882 888 893 917 928 Target Secruence

GACAGAAU

ACAGAAU

AGAAUJAU

GAAUUAUU

AAUUAUUU

GCAGAAAU

GCAAAGCU

GAACUGAU

AUAAUG CU

AAUGCUAU

ACUGGAAU

CUGGAAUU

GGAAUJCU

CAAUGCGU

CGGAAGGU

AGGAAGGU

GGAAGGUU

AAGGUTUAU

GCAGGAGU

AGGAGUC)

GGAGUCUJ

CACAAGCU

ACAAGCLU

AGAACAGU

ACAGUCAU

CAGUCAU)

UGAUGGGU

GAUGGGLU

AUGGGUTE

GUUUUGCU

CU CAGG CU

CUCCGCCU

CUACAGCU

GCUCAACU

CCCACUGU

CAACGACU

AUTTUACCA

DIJACCAG

UACCAGGC

ACCAGGCA

CCAGGCAC

GCAAAGCU

CUGCCUGG

AUGCUAUC

UCAAGAAC

AAGAACCA

CUACAAUG

UACAAUGC

CAAUGCGU

GGAAGGUC

GAACAGGA

AUCUGCAG

UCUGCAGG

UGCAGGAG

UU)CAAAAG

CAAAAGCC

AAAAGCCA

CCAGAAGA

CAGAAGAA

AUTJUGAUG

UGAUGGGU

GAUGGGU

IJUGCUCAG

UGCUCAGG

GCUCAGGC

AGGCUCCG

CGCCUACA

CAGCUCAA

AACUCCCU

CCUGCCAC

AACAACGA

UUCCUAUU

UGGUAAAU

CUGGUAAA

GCCUGGUA

UGCCUGGU

GUGCCUGG

AGCUUUGC

CCAGGCAG

GAUAGCAU

GUUCUTJGA

UGGUJCUJ

CAUUGUAG

GCAUTJGUA

ACGCAUUG

GACCUUCC

UCCUGTJUC

CUGCAGAU

CCUGCAGA

CUCCUGCA

CUUUUGAA

GGCUUUUG

UGGCUUUU

UCUUCUGG

UUCUUCUG

CAUCAAAU

ACCCAUCA

AACCCAUC

CUGAGCAA

CCUGAGCA

GCCUGAGC

CGGAGCCU

UGUAGGCG

UUGAGCUG

AGGGAGUU

GUGGCAGG

UCGTJUGUU

AAUAGGAA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GA.A

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

AULJCUGUC

AAUTJCUGU

AUAAUUCU

AAUAAUUC

AAAUAAUU

AUUUCUG C AGCUJG C

AUCAGUUC

AGCAUUAU

AUAGCAUU

AUUCCAGU

AAUIJCCAG

AGAAUUC C

ACGCAUUG

ACCUUCCG

AC CUUC CU AACCUJC C

AUAACCUJ

ACUCCUGC

AGACUC CU

AAGACUCC

AG CUUGUG AAGCUUG3U

ACUGUTJCU

AUGACUGU

AAUGACUG

ACCCAUCA

AACC CAUC

AAACCCAU

AG CAAAAC

AGCCUGAG

AGGCGGAG

AGCUGUAG

AGUUGAGC

ACAGUGGG

AGUCGUUG

Targe Seqence Ribozvme Sequence nt.

Position 930 931 934 936 937 944 945 946 962 964 969 974 975 979 15 986 991 992 1002 1004 1007 1013 1017 1037 1048 1050 1082 1090 1091 1096 1100 1103 1108 1124 1184 1203 Target SQquence

ACGACUAU

CGACUAUJ

CUAUUCCU

AUTJCCUAU

UTJCCUAUU

UACCACAU

ACCACAUU

C CACAUU CAAAAtJGU

AAAUGUCU

UCUCCAGU

AGUCAUGU

GUCAUGU)

UGUUCCAU

UACCCUGU

UGUAGCGU

GUAGCGUU

AUGUAAAU

GUAAAUAU

AAUAUAGU

GUCAAUGU

AUGUCCCU

GCAGCCAU

GAGACACU

GACACUAU

AAGCGAAU

AMAAGGAAU

AAGGAAUU

AUUAGAAU

GAAUUGCU

UTJGCUCCU

CCUAAUGU

AAUGAGCU

ACCACCAU

CCAGACCU

C CUATJUAC

CUAUUACC

UUACCACA

ACCACAUU

CCACAUUU

UCUGAAGC

CUGAAGCA

UGAAGCAC

UCCAGUCA

CAGUCAUG

AUGUUCCA

CCAUACCC

CAUACCCU

CCCUGUAG

GCGUUACA

ACAUGUAP.

CAUGUAAA

UAGUCAAU

GUCAAUGU

AAUGUCCC

CCUCAGCC

AGCCAGCU

CAGAGACA

UAAUGAUG

AUGAUGAA

AAGGAAUU

AGAAUUGC

GAAUUGCU

GCUCCUAA

CUAAUGUC

AUGUCAAC

AACCGAGA

AAAGGACA

GCCGACCA

AUGGAGAC

GUAAUAGG

GGUAAUAG

UGUGGUAA

AAUGUGGU

AAAUGUGG

C CUUCAGA

UGCUUCAG

GUGCUUCA

UGACUGGA

CAUGACUG

UGGAACAU

GGGUAUGG

AGGGUAUG

CUACAGGG

UGUAACGC

UUACAUGU

UUUACAUG

AUUGACUA

ACAUUGAC

GGACAUU C

GGCUGAGG

AGCUGGCU

UGUCUCUG

CAUCAUUA

UUCAUCAU

AAUUCCUU

GCAAUTUCU

AGCAAUUC

UUAGGAG C

GACAUUAG

GUUGACAU

UCUCGGUTJ

UGUCCUUU

UGGUCGGC

GUCUCCAU

CUGAUGA X GAP. AUAGUCGU CUGAUGA X GAA AAUAGUCG CUGAUGA X GA. AGGAP.UAG CUGAUGA X GA. AUAGGAAU CUGAUGA X GAA AAUAG GA.

CUGAUGA X GAA AUGUGGUA CUGAUGA X GAP. AAUGUGGU CUGAUGA X GAA AAAUGUGG CUGAUGA X GAA ACAUUUUG CUGAUGA X GAP. AGACAUIU CUGAUGA X GAA ACUGGAGA CUGAUGA X GAP. ACAUGACU CUGAUGA X GAP. AACAUGAC CUGAUGA X GAA AUGGAACA CUGAUGA X GAP. ACAGGGUA CUGAUGA X GAA ACGCUACA CUGAUGA X GAP. AACGCUAC CUGAUGA X GAP. AUUUACAU CUGAUGA X GAP. AUAUUUAC UtGAUGA X GAP. ACUAUAUU CUGAUGA X GAP. ACAUUGAC CUGAUGA X GAP. AGGGACAU CUGAUGA X GAP. AUGGCUGC CUGAUGA X GAP. AGUGUCUC CUGAUGA X GAA AUAGUGUC CUGAUGA X GAP. ATJUCGCUU CUGAUGA X GAA AUUCCUUU CUGAUGA X GAP. AP.UUCCUU CUGAUGA X GAP. AUUCUAP.U CUGAUGA X GAP. AGCAAUTJC CUGAUGA X GAP. AGGAGCAA CUGAUGA X GAP. ACAUUAGG CUGAUGA X GAP. AGCUCAUTI CUGAUGA x GAP. AUGGUGGU CUGAUGA X GAP. AGGUCUGG Targe Seqence Ribozyme Sequence 1223 GCACCUGU U UCCUGUUU 1223 GCACUGU UCCGUUUAAACAGGA CUGAUGA X GAP. ACAGGUGC p nt Posi tion 1224 1225 1230 1231 1246 1251 1255 1257 1269 1276 1280 1297 1316 1319 15 1334 1335 1341 1346 1347 1355 1357 1358 1363 1364 1376 1381 1382 1383 1385 1389 1390 1392 1393 1394 1396 1397 Target Sequence CACCUGUU U ACCUGUUU C UTJCCUGU U UUCCUGUU U ACACCACU C ACUCCACU C CACUCCAU C CUCCAUCU C CAGCGGAU C UCCUGGCU C GGCUCCCU A AAGCGCCU C UGCAUGAU C AUGAUCGU C GGCACCAU U GCACCAUJ C UUCUGGAU A GAUAAUGU U AUAAUGLJU A AAGAACCU C

CCUGUTJUG

CUGUUUGG

UGGGAGAA

GGGAGAAC

CACUCCAU

CAUCUCUG

UCUGCCAG

UGCCAGCG

CUGGCUCC

CCUACCUG

CCUGAAGA

GCCAGCAA

GUCCACCA

CACCAGGG

CUGGAUAA

UGGAUAAU

AUGUIJAAG

AAGAACCU

AGAACCUC

UTJAGAAtU

CAAACAGG

CCAAACAG

UUCUCCCA

GUTJCUC CC

AUGGAGUG

CAGAGAUG

CUGGCAGA

CGCUGGCA

GGAGCCAG

CAGGUAGG

UCUUCAGG

UTJGCUGGC

UGGUGGAC

CCCUGGUG

UUAUCCAG

AUUAUCCA

CUUAACAU

AGGLTUCUU

GAGGUUCU

AAUUCUAA

CAAAUUCU

GCAAAUTJC

tJUUCUGCA

GUUTJCUGC

AUAAAUUG

AAUCUAUA

GAAUCUAU

AGAAUCUA

AAAGAAUC

UAAGAAAG

UUAAGAA.A

GUUUAAGA

UGUUUAAG

GUGUUTUAA

AAGUGUUU

GAAGUGUU

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

X GAA AACAGGUG X GAA AAACAGGU X GAA ACAGGAAA X GAA AACAGGAA X GAA AGUGGUGU X GAA AGUGGAGU X GAA AUGGAGUG X GAA AGAUGGAG X GAA AUCCGCUG X GAA AGCCAGGA X GAA AGGGAGCC X GAA AGGCGCUU X GAA AUCAUCCA X GAA ACGAUCAU Ribozyme Sequence GAACCUCU U AGAAUUUG AACCUCU= A GAAUUUGC CUUAGAAU U UGCAGAAA UUAGAAUTJ U GCAGAAAC GAAACACU C CAAUUUAU ACUCCAAU U UAUAGAUU CUCCAAUU U AUAGAUUC UCCAAUU A UAGAUUCU CAAUUUAU A GAUUCUUU UUAUAGAU U CUUUCUUA UAUAGAUIJ C UUUCUUAA UAGAUUCU U UCUTJAAAC AGALTUCUTJ U CUTUAAACA GAUUCUUU C UUAAACAC UUCUTJUCU U .AAACACUU UCUUUCUU A AACACUUC CUGAUGA X GAA AUGGUGCC CUGAUGA X GAA AAUGGUGC CUGAUGA X GAA AUCCAGAA CUGAUGA X GAA ACAUUAUC CUGAUGA X GAA AACAUUAU CUGAUGA X GAA AGGUUCUU CUGAUGA X GAA AGAGGUUC CUGAUGA X GAA AAGAGGUJ CUGAUGA X GAA AUUCUAAG CUGAUGA X GAA AAUUCUA-A CUGAUGA X GAA AGUGUTTC CUGAUGA X GAA AUUGGAGU CUGAUGA X GAA AAUUGGAG CUGAUGA X GAA AAAUUGGA CUGAUGA X GAP. AUAA-AUUG CUGAUGA X GAP. AUCUAUAA CUGAUGA X GAP. AAUCUAUA CUGAUGA X GAP. AGAAUCUA CUGAUGA X GAP. AAGAAUCU CUGAUGA X GAP. AAAGAAUC CUGAUGA X GAA AGAAAGAA CUGAUGA X GAP. AAGAAAGA a.

a.

a a a. a. a a a a. a. nt.

Position 1404 1405 1410 1423 1429 1440 1441 1443 1444 10 1445 1449 1450 1460 1463 15 1467 1474 1481 1482 1492 1493 1494 1497 1518 1530 1535 1536 1537 1538 1539 1551 1553 1561 1565 1567 1568 1578 Target Sequence UAAACACU U CCAGUAAC AAACACUJ C CAGUAACC CUIJCCAGU A ACCAUGAA UGAAAACU C AGACUJGG CUCAGACU U GGAAAUGC AAAUGCCU U CUTITAACU AAUGCCUU C UUUAACUJ UGCCUUCU U UAACUUCC GCCtJUCUU U AACUTJCCA CCUTJCIUUJ A ACUUCCAC CUUTJAACU U CCACCCCC UUEJAACTJU C CACCCCCC ACCCCCCU C AUIJGGUCA CCCCUCAU U GGUCACAA UCAUUGGU C ACAAAUTJG UCACAAAU U GACUGUUA UUGACUGU U ACAACACC UGACUGUU A CAACACCA AACACCAU U UCAUAGAG ACACCAUU U CAUAGAGA CACCAJUTI C AUAGAGAC CAUTJUCAU A GAGACCAG UGAAAACU C AAAAGGAA AGGAAAAU A CUGUI)TJU AAUACUGU U =UIAGAAC AUACUGUU U UUAGAACC UACUGUUU U UAGAACCC ACUGUUUU U AGAACCCC CUGUJUTJTJ A GAACCCCA CCCCAGCU A UCAAAAGG CCAGCUAU C AAAAGGUC CAAAAGGU C AAUCUUAG AGGUCAAU C UUAGAAAG GUCAAUCU U AGAAAGCU UCAAUCtJU A GAAAGCUC AAAGCUCU C CAAGAACU

*GUUACUGG

GGIJUACUG

UUCAUGGU

CCAAGUCU

GCAUUUCC

AGLUJAAAG

AAGUUAAA

GGAAGUUJA

UGGAAGUU

GUGGAAGU

GGGGGUGG

GGGGGGtJG

UGACCAAU

UUGUGACC

CAAUUUGU

UAACAGUC

GGUGUrJGU

UGGUGUUG

CUCUAUGA

UCUCUAUG

GUCUCtJAU

CUGGUCUC

UUCCUTuuu AAAAACAG C GUTJCUAAA C GGUUCUAA C GGGUUTCUA C GGGGtJUCU C UGGGGUTJC C CCUUUUGA C GACCUI=J C CTJAAGAUU C CTJUUCUAA

C

AGCUUUCU C

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA CUGAUGA X< CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X UGAUGA X 7UGAUGA X 'UGAUGA X UGAUGA X UGAtJGA X UGAUGA X UGAUGA X :UGAUGA X UGAUGA X 'UGAUGA X 'UGAUGA X 'UGAUGA X UGAUGA X UGAUGA X UGAUGA X GAA AGUGUUUA GAA AAGUGUTU GAA ACtJGGAAG GAA AGUTJUUCA GAA AGUCUGAG GAA AGGCAUTU K~ GAA AAGGCAUU K GAA AGAAGGCA (GAA AAGAAGGC GAA AAAGAAGG GAA AGUUAAAG GAA AAGUUAAA GAA AGGGGGGU GAA AUGAGGGG GAA ACCAAUGA GAA AUTJTGUGA GAA ACAGUCAA GAA AACAGUCA GAA AUGGUGUJ GAA AAUGGUGU GAA AAAUGGUG GAA AUGAAAUG GAA AGUUUJUCA GAA AUTJUCCU GAA ACAGUAUTJ GAA AACAGUAU GAA AAACAGUA GAA AAAACAGU GAA AAAAACAG GAA AGCUGGGG GAA AUAGCUGG GAA ACCUJUG GAA AUUGACCU GAA AGAUUGAC GAA AAGAUIJGA GAA AGAGCUUU Ribozvme Seguence a. a a a a a GAGCUUUC CUGAUGA X AGUUCUUG CUGAUGA X p. S p p nt.

Position 1587 1590 1597 1598 1610 1617 1625 1G26 1635 10 1649 1653 1663 1665 1668 15 1670 1673 1680 1694 1705 1714 1721 1724 1732 1733 1753 1754 1766 1783 1785 1794 1798 1807 1808 1810 1811 1816 Target Seqruence

CAAGAACU

GAACUCCU

UACACCAU

ACACCAUU

CAUGCACU

UUGCAGCU

CAAGAAAU

AAGAAAU

AAUACGGU

AAGAUG CU

UGCUACCU

GACACCCU

CACCCUCU

CCUCUCAU

UCUCAUCU

CAUCUAGU

UAGAAGAU

GAUGUGAU

ACAGGAAU

UGAUGAAU

UCUGGAAU

GGAAUUGU

UGCUGAGU

GCUGAGUU

AC CACC CU

CCACCCUU

AAGAAAAU

GGUGGAAU

UGGAAUCU

CAACUGAU

UGAUAAAU

AGGAAACU

GGAAACUU

AAACUUCU

AACUUCUTJ

CUUCUGCU

CUACACCA

CACCAUJC

CAAACAUG

*AAACAUGC

*GCAGCUCA

AAGAAAU

AAAUACGG

AAUACGGU

CCCUGAAG

C CU CAGA C

AGACACCC

UCAUCUAG

AUCUAGUA

UAGUAGAA

GUAGAAGA

GAAGAUCU

UGCAGGAU

AAACAGGA

UGAUGAAU

UGGAAtJUG

GUUGCUGA

GCUGAGUU

UCAAGAAA

CAAGAAAA

ACUGAAGA

CUGAAGAA

A.AACAAGA

UCCAACUG

CAACUGAU

AAUCAGGA

AGGAAACU

CUUCUGCU

UUCUGCUC

CUGCUCAC

UGCUCACA

ACACCACU

UGGUGUAG

GAAUGGUC

CAUGUUUG

GCAUGUUTJ

UGAGCUGC

AAUUUCUU

CCGUAUUU

ACCGUAUU

CUUCAGGG

GUCUGAGG

GGGUGUCU

CUAGAUGA

UACUAGAU

UUCUACUA

UCUUCUAC

AGAUCtIUC

AUCCUGCA

UCCUGUUU

AUUCAUCA

CAAUUCCA

UCAGCAAC

AACUCAGC

UUUCUUGA

UIUUCUJG

UCUUCAGU

UUCUUCAG

UCUUGUTU

CAGUUGGA

AUCAGUUG

UCCUGAUU

AGUTJUCCU

AGCAGAAG

GAGCAGAA

GUGAGCAG

UGUGAGCA

AGUGGUGU

CUGAUGA X GAA AGUUCUUG CUGAUGA X GAA AGGAGUTJC CUGAUGA X GAA AUGGUGUA CUGAUGA X GAA AAUGGUGU CUGAUGA X GM-A AGUGCAUG CUGAUGA X GAA AGCUGCAA CUGAUGA X GAA AUUUCUUG CUGAUGA X GAA AAUUUCJUU CUGAUGA X GAA ACCGUAUU CUGAUGA X GAA AGCAUCUU CUGAUGA X GAA AGGUAGCA CUGAUGA X GAA AGGGUGUC CUGAUGA X GAA AGAGGGU3 CUGAUGA X GAA AUGAGAGG CUGAUGA X GAA AGAUGAGA CUGAUGA X GAA ACUAGAUG CUGAUGA X GAA AUCUUCUA CUGAUGA X GAA AUCACAUC CUGAUGA X GAA AUUCCUGU CUGAUGA X GAA AUUCAUCA CUGAUGA X GAA AUTJCCAGA CUGAUGA X GAA ACAAIJUCC CUGAUGA X GAA ACUCAGCA CUGAUGA X GAA AACUCAGC CUGAUGA X GAA AGGGUGGU CUGAUGA X GAA AAGGGUGG CUGAUGA X GAA AUUUUCUU CUGAUGA X GAA AUUCCACC CUGAUGA X GAA AGAUTJCCA CUGAUGA X GAA AUCAGUUG CUGAUGA X GAA AUUUAUCA CUGAUGA X GAA AGUUUCCU CUGAUGA X GAA AAGUUUCC CUGAUGA X GAA AGAAGUUU CUGAUGA X GAA AAGAAGUU CUGAUGA X GAA AGCAGA.AG Ribozyme Sequence .9 9 9 .9 a.

99 9999*9 9 99*9 49 a 9. 9 9 9 99 9* 9 9*9 9* 99 9 9.9.

9 *9 9.

.9 9 9 nt.- Position 1839 1845 1855 1856 1867 1890 1892 1893 1895 10 1896 1903 1907 1908 1909 15 1910 1924 1943 1944 1946 1954 1955 1956 1961 1965 1975 1990 1998 2001 2007 2023 2053 2055 2056 2061 2067 2070 Target Seq~uence

GGGACAGU

GUCUGAAU

CCAACUGU

CAACUGUTJ

GCAGACCU

CACCGAAU

CCGAAUAU

CGAAUAUU

AAUAUUCU

AUATJUCUU

UACAAGCU

AG CUCCGU

GCUCCGUU

CUCCGUUU

UCCGUUUIJ

ACCAGCAU

GACAAUGU

ACAAUGLU

AAUGUUCU

CAAAGCAU

AAAGCALU

AAGCAUU

UUTACAGU

CAGUACCU

AAACAGGU

GAGCCCCU

UGCAGCCU

AGCCUUGU

GUAGCAGU

ACCUGCAU

GAUGACAU

UGACAUCU

GACAUCUU

CUUCCAGU

GUCAAGCU

AAGCtJCGU

UGAAUACC

CCCAACUG

CACGCAGA

ACGCAGAC

GCCUGUGG

UU)CUUA CA

CUTJACAAG

UTJACAAGC

ACAAGCUC

CAAGCUCC

CGtJUUUAA

UUAAUGGC

UAAUGGCA

AAUGGCAC

AUGGCACC

AGAAGAUG

CUCAAAGC

UCAAAGCA

AAAGCAUU

UACAGUAC

ACAGUACC

CAGUACCU

CCUAAAAA

AAAACAGG

CCUGGCGA

GCAGCCUJ

GUAGCAGU

GCAGUACC

CCUGGGAA

CUGUGGAA

UUCCAGUC

CCAGUCAA

CAGUCAAG

AAGCUCGU

GtJAAAUAC

AAUACGUG

GGUAUUCI

CAGUUGGCG

UCUGCGUG-

GUCUGCGU

CCACAGGC

UGUAAGA-A

CtJUGUAAG

GCUUGUAA

GAGCUUGU

GGAGCUUG

UTUAAAACG

GCCAtJUAA

UGCCAUJA

GUGCCAUU

GGUGCCAU

CAUCUUCU

GCUUUGAG

UGCUUUGA

AAUGCUUU

GUACUGUA

GGUACUGU

AGGUACUG

UTJUUAGG

CCUGtUUU

UCGCCAGG

AAGGCUGC

ACUGCUAC

GGUACUGC

UUCCCAGG

UUCC.ACAG

GACUGGAA

IJUGACUGG

CUTJGACUG

ACGAGCU

GUAUUAC

CACGUAUU

CUGAUGA X GAA ACUGUCCC

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA AUUCAGAC GAA ACAGUUGG GAA AACAGUUG GAA AGGUCUGC GAA AUTJCGGUG GAA AUAUUCGG GAA AAUAUUCG GAA AGAAUATJTU GAA AAGAAUAU GAA AGCU-UGUA GAA ACGGAGCU GAA AACGGAGC GAA AAACGGAG GAA AAAACGGA GAA AUG CUGGU GAA ACAUTJGUC GAA AACAUUGU GAA AGAACAUU GAA AUGCUTJUG GAA AAUGCULU GAA AA-AUGCUU GAA ACUGUAAA GAA AGGUACUG GAA ACCUGUUJ GAA AGGGGCUC GAA AGGCUGCA GAA ACAAGGCU GAA ACUGCUAC GAA AUGCAGGU GAA AUGUCAUC GAA AGAUGUCA GAA AAGAUGUC GAA ACUGGAAG GAA AGCUUGAC GAA ACGAGCUU Ribozyme Sequence *6 4 4 9*

*VOV

V

Ve .9 S 9 nt.

Posi tion 2074 2086 2087 2089 2105 2117 2118 2119 2131 10 2132 2137 2136 2139 2140 2149 2150 2155 2160 2166 2168 2170 2173 2174 2177 2189 2190 2191 2192 2212 2214 2215 2216 2217 2220 2226 2234 Target SQquence

I.

*99t 9 *909 9999 9. *4 V 9

V

9 8

UCGUAAAU

GAAUGCAU

AAUGCAUU

UGCATJUCU

ACGCUGGU

UGAGACAU

GAGACAUJ

AGACAUUU

AAAAGCAU

AAAGCAUU

AUUAUGGU

UUAUGGUJ

UAUGGUUUE

AUGGUUUU

AGAACACU

GAACACUJ

CtIUCAAGU

AGUUGACU

CUGGGAU

UGGGAUAU

GGAUAUAU

UAUAUCAU

AUAUCAUU

UCAUUCCU

AUGAAACU

UGAAACU

GAAACUUU

AAACUUU

AAGAACCU

GAACCUAU

AACCUAUU

ACCUAUUJ

CCUAUULJU

AUUUUUGU

GUUGUGGU

ACAACAGU

CGUGAAUG

CUCAGCCC

UCAGCCCG

AG CCCGGA

AUGUGAGA

UC CAGAAA

CCAGAAAA

CAGAAAAG

AUGGUUUU

UGGUTJUC

UUCAGAAC

UCAGAACA

CAGAACAC

AGAACACU

CAAGtJUGA

AAGLUGAC

GACUUGGG

GGGAUAUA

UAUCATJUC

UCAUUCCU

AUUCCUCA

CCUCAACA

CUCAACAU

AACAUGAA

UTJCAUGAA

UCAUGAAU

CAUGAAUG

AUGAAUGG

UUUUUGUU

UUUGUUGU

UUGUUGUG

UGUTJGUGG

GUUGUGGU

GUGGUACA

CAACAGUU

GAGAGCAG

CAUUCACG

GGGCUGAG

CGGGCUGA

UCCGGGCU

UCUCACAU

UUUCUGGA

UUUUCUGG

CUUUUCUG

AAAACCAU

GAAAACCA

GUIJUCUGAA

UGUIJUCUGA

GUGUTJCUG

AGUGUJCU

UCAACUUG

GUCAACUU

CCCAAGUC

UAUAUCCC

GAAUGAUA

AGGAAUGA

UGAGGAAU

UGUUGAGG

AUGUUGAG

UIJCAUGUU

UUCAUGAA

ALUJCAUGA

CAUUCAUG

C CAUTJCAU

AACAAA.AA

ACAACAAA

CACAACAA

CCACAACA

ACCACAAC

UGUACCAC

AACUGIJUG

CUGCUCUC

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

Targe SeqenceRibozyme Sequence GAA AUUUACGA GAA AUG CAUTJC GAA AAUGCAL-TU GAA AGAAUGCA GAA ACCAGCGU GAA AUGUCUCA GAA AAUGUCUC GA7A AAAUGUCU GAA AUGCUUTTJU GAA AAUGCUIU GAA ACCAUAAU GAA AACCAUAA GAA AAACCAUA GAA AAAACCAU GAA AGUGUUCU GAA AAGUGUUC GAA ACUUGAAG GAA AGUCAACU GAA AUCCCAAG GAA AUAUCCCA GAA AUAUAUCC GAA AUGAUAUA GAA AAUGAUAU GAA AGGAAUGA GAA AGUUTUCAU GAA AAGIJUUCA GAA AAAGUUJC GAA AAAAGUU GAA AGGUUCUJ GAA AUAGGUUC GAA AAUAGGUJ GAA AAAUAGGU GAA AAAAUAGG GAA ACAAAAAU GAA ACCACAAC GAA ACUGUEJGU a.

nt.

Posi tion 2255 2256 2 257 2260 2270 2272 2273 2275 2280 2281 2282 2291 2299 2300 2301 2302 2309 2313 2319 20 2321 2322 2326 2330 2331 2333 2334 2338 2345 2348 23SS 23S8 2359 2362 2364 2366 Target Sequence AAGUG CAU

AGUGCAUU

GUGCAUTJ

CAUUTAGU

AAUGAAGU

UGAAGUCU

GAAGUCUU

AGUCUUCU

UCUUGGAU

CUUGGAUJ

UUGGAUU

ACCCAACU

AAAAGGAU

AAAGGAUU

AAGGAUUU

AGGAUUU

UUAAAAAU

AAAUAAAU

AUAACAGU

AACAGUCU

ACAGUCIU

UCUEJACCU

ACCUAAAU

C CUAAATU

UAAAUUAU

AAAUUAUU

UAUUAGGU

UAAUGAAU

UGAAUUGU

UAGCCAGU

CCAGUUGU

CAGUUGUU

UTJGUUAAU

GUUAAUAU

UAAUAUCU

UAGTJUGAA

AGUUGAAU

GUIJGAAUG

GAAUGAAG

UUCUUGGA

CTJUGGAUJ

UTJGGAUTJ

GGAUTJUCA

UCACCCAA

CACCCAAC

ACCCAACU

AAAGGAUU

UUUAAAAA

UUAAAAAU

UAAAAAUA

AAAAAUAA

AAUAACAG

ACAGU=U

UUACCUAA

ACCUAAAU

CCUAAAUU

AAUUAUUA

ATJUAGGUA

UUAGGUAA

AGGUAAUG

GGUAAUGA

AUGAAUUG

GUAG CCAG

GCCAGUUG

GUTJAAUAU

AAUAUCUJ

AUAUCTJUA

UCUTJAAUG

UUAAUGCA

AAUGCAGA

UUCAACUA

AUTJCAACU

CAUUCAAC

CUTJCAUUC

UCCAAGAA

AAUCCAAG

AAAUCCAA

UGAAAUCC

UUGGGUGA

GUUGGGUG

AGUTJGGGU

AAUCCUUU

UUUUUAAA

AUUtJUUAA

UAUUUUUA

UUAUUtU

CUGUUAUU

AAGACUGU

UTJAGGUAA

AUUUAGGU

AAULTUAGG

UAAUAAUU

UACCUAAU

UUACCUAA

CAUUA CCU

UCAUUACC

CAAUUCAU

CUGGCUAC

CAACUGGC

AUAUUAAC

AAGAUAUJ

UAAGAUAU

CALTUAAGA

UGCALUAA

UCUGCAUU

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUJGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

AUGCACU'U

AAUGCACU

AAAUG CAC

ACUAAAUG

ACUUCAUTJ

AGACUUCA

AAGACUUC

AGAAGACU

AUCCAAGA

AAUCCAAG

AAAUC CAA

AGUUGGGU

AUCCUUUU

AAUCCUUUJ

AAAUCCUU

AAAAUCCU

AtTUUUUAA

AUI=AUTJ

ACUGUIJAU

AGACUGUU

AAGACUGU

AGGUA-AGA

AUUtUAGGU

AAUTJUAGG

AUAAUTJA

AAUAAUUU

ACCUAAUA

AUUCAUUA

ACALAUUCA

ACUGGCUA

ACAACUGG

AACAACUG

AUUAACAA

AUAUTUAAC

AGAUAUTJA

Targe Seqence Ribozvme Sequence 2367 AAUAuCLTu A AUGCAGAU 2367 AAUACUU AUGAGAUAUCUGCAU CUGAUGA X GAA AAGAUAUIJ nt.- Position 2376 2377 2378 2379 2380 2381 2382 2393 2401 2402 2403 2405 2409 2411 2412 2413 2414 2421 2430 20 2434 2436 2437 2438 2439 2440 2441 2453 2454 2455 2456 2457 2463 2464 2472 2473 2480 Target Sequence

AUGCAGAU

UG CAGATU G CAGAUUU

CAGAUIUU

AGAUUTJTTU

GAUUUIU

AUUUTUUU

AAAAACAU

AAAAUGAU

AAAUGAUU

AAUGAUUJ

UGAUIJUAU

UUAUCUGU

AUCUGUAU

UCUGUAUU

CUGUAUUU

UGUAUUUU

UAAkAGGAU

CAACAGAU

AGAUCAGU

AUCAGUAU

UCAGUAUU

CAGUAULTU

AGUAUUUU

GUAUUTUUU

UALUTUUU

UGAUGGGU

GAUGGGU

AUGGGUU

UGGGUUU

GGGUUUUU

UUUGAAAU

UUGAAAUJ

UGACACAU

GACACAUU,

UAAAAGGU.

UUUUUAAA

UUUAAAAA

UUUAAAAA

UAAAAAAA

UAAAAAAC

AAAUGAUU

UAUCUGUA

AUCUGUAU

UCUGUAUJ

UGUAUUU

tUUUAAAG

UUAAAGGA

UAAAGGAU

AAAGGAUC

AAGGAUCC

CAACAGAU

AGUAUUUU

UUUUtucc

UUUUCCUG

UUUCCUGU

UTJCCUGUG

UCCUGUGA

CCUGUGAU

CUGUGAUG

UUUUGAAA

UEJUGAAAU

UUGAAAU

UGAAAUU

GAAAUUUG

UGACACAU

GACACAUU

AAAAGGUA

AAAGGUA-C

CUCCAGUA

UUUAAAAA

UUUAAAA

UUUUUUAA

UUUTUUUUA

GUUUUJTJ

AAUCAUTU

UACAGAUA

AUACAGAU

AAUACAGA

AAAAUACA

CTJUUAAAA

UCCUUUAA

AUCCUUJA

GAUCCUUU

GGAUCCUJ

AUCUGUUG

AAAAUACU

GGAAAAAA

CAGGAAAA

ACAGGAAA

CACAGGAA

UCACAGGA

AUCACAGG

CAUCACAG

UUUCAAAA

AUUUCAAA

AALUUCAA

AAAUTIUCA

CAAAUUC

AUGUGUCA

AAUGUGUC

UACCUUUU

GUACCUUU

UACUGGAG

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

Targe SeqenceRibozyme Seqruence GAA AUCUGCAU GAA AAUCUGCA GAA AAAUCUGC GAA AAAAUCUG GAA AAAAAUCU GAA AAAAAAUC GAA AAAAAAAU GAA AUGUUTUU GAA AUCAUTUU GAA AAUCAUU GAA AAAUCATU GAA AUAAAUCA GAA ACAGAUAA GAA AUACAGAU GAA AAUACAGA GAA AAAUACAG GAA AAAAUACA GAA AUCCUUUA GAA AUCUGUUG GAA ACUGAUCU GAA AUACUGAU GAA AAUACUGA GAA AAAUACUG GAA AAAAUACU GAA AAAAAUAC GAA AAAAAAUA GAA ACCCAUCA GAA AACCCAUC GAA AAACCCAU GAA AAAACCCA GAA AAAAACCC GAA AUUUCAA GAA AAUUUCAA GAA AUGUGUCA GAA AAUGUGUC GAA ACCUUUUA 0* nt.

Position 2488 2490 2491 2492 2496 2497 2498 2501 2505 10 2509 2515 2521 2523 2525 15 2526 2527 2528 2529 2535 2539 2547 2548 2551 2553 2559 2564 2565 2568 2580 2581 2582 2585 2591 2594 2601 2604 Target Sequence ACUC CAGU

UCCAGUAU

CCAGUAUU

CAGUAUU

AUUTJCACU

UUUCACUJ

UUCACUU

ACUUTJUCU

UUCUCGAU

CGAUCACU

CUAAACAU

AUAUGCAU

AUG CAUAU

GCAUAUAU

CAUAUAUU

AUAUAUU

UAUALtJT=

AUAUULUU

UUAAAAAU

AAAUCAGU

AAAAGCAU

AAAGCAUU

GCAUUACU

AUUACUCU

CUAAGUGU

UGUAGACU I

GUAGACUU

GACU7TJAAU UGUGACAU I

GUGACAUUI

UGACAUTJ

CAUUUAAU(

AUCCAGAU

I

CAGALTUGU I

UAAAUGCU

AUG CUCAU I k. UTJUCACUU J UCACUUU J CACUUUUC

ACUUUCU

J UUCUCGAU

JUCUCGAUC

JCUCGAUCA

*GAUCACUA

ACUAAACA

AACAUAUG

*UGCAUAUA

*UAUUUUJA

UUUUUAAA

UUUAAAA-A

UUAAAAAU

UAAAAAUC

AAAAAUCA

AAAAUCAG

AGUAAAAG

AAAGCAU

ACUCUAAG

CUCUAAGU

UAAGUGUA

AGUGUAGA

GACUUAAU

AAUACCAU

AUACCAUG

CCAUGUGA

UAAUCCAG

AAUC CAGA

AUCCAGAU

CAGAUUGU

GUAAAUGC

AAUGCUCA

AUUUAUGG

UAUGGLTUA

AAGUGAAi

AAAAGUG

GAAAAGUC

AGAAAAGI

AUCGAGA7

GAUCGAGI

UGAUCGAC

UAGUGAUC

UGULTUAGL

CAUAUGU

UAUAUGCA

UAAAAAUA

UUUAAAAA

UUUUUAAA

AUUUTJAA

GAUUUUTUA

UGAUUULU

CUGAUUUJ

CUUUEJACU

AAUGCUUU

CUUAGAGU

ACUIJAGAG

UACACUUA

UCUACACU

AtJUAAGUC

AUGGUAUU

CAUGGUAU

UCACAUGG

CUGGAUUA

UCUGGAUU

AUCUGGAU

ACAAUCUG

GCAUUUAC

UGAGCAUU

CCAUAAAU

UAACCAUA

kCUGAUGA

CUGAUGA

3CUGAUGA 3CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA CUGAUGA CUGAUGA Y CUGAUGA Y CUGAUGA Y CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X X GAA ACUGGAGU X GAA AUACUGGA X GAA AAUACUGG K GAA AAAUACUG K GAA AGUGAAAU GA-A AAGUGAAA (GA-A AAAGUGAA GAA AGAAAAGU CGAA AUCGAGAA GAA AGUGAUCG GAA AUGUUJAG GAA AUGCAUAU GAA AUAUGCAU IGAA AUAUAUGC GAA AAUAUAUG GAA AAAUAUAU GAA AAAAUAUA GAA AAAAAUAU GAA AUUTUUUAA GAA ACUGAUtU GAA AUG CUTUTJ GAA AAUGCUU GAA AGUAAUGC GAA AGAGUAAU GAA ACACUTIAG GAA AGUCUACA GA-A AAGUCUAC GAA AUTJAAGUC GAA AUGUCACA GAA AAUGUCAC GAA AAAUGUCA GAA AUUAAAUG GAA AUCUGGAU GAA ACAAUCUG GAA AGCAUUUA GAA AUGAGCAU Ribozyme Seqruence S

S

nt.

Position 2605 2606 2611 2612 2620 2627 2631 2632 2633 10 2635 2638 2648 2649 2650 15 2651 2657 2658 2659 2660 2664 2665 2669 2G73 2674 2675 2681 2682 2684 2685 2690 2697 2700 2701 2702 2703 Target Sequence

UGCUCAUU

GCUCAUUU

UTJUAUGGU

UUAUGGUU

AAUGACAU

UUGAAGGU

AGGUACAU

GGUACALU

GUACAUTJ

ACAUUUAU

UEJUALUGU

CAAACCAU

AAACCAUU

AACCAUTI

ACCAUUU

UtJAUGAGU

UAUGAGUJ

AUGAGUUJ

UGAGULUU

UUUUCUGU

TJUUCUGUU

UGUUAGCU

AGCUUGCJ

GCUUGCUU

CUIJGCUTU

UTJAAAAAU

UAAAAALU

AAAAUTUAU

AAAUJALU

AUUACUGU

UAAGAAAU

GAAAUAGU

AAAUAGUJ

AAUAGUUU

AUAGUUUU

AUG GtUAA

UGGUUAAU

AAUGACAU

AUGACAUU

GAAGGUAC

CAUTJUAUU

UAUUGUAC

AUUGUA CC

UUGUACCA

GUACCAAA

CCAAACCA

UEJAUGAGU

UAUGAGUU

AUGAGUUU

UGAGUUUJ

UTJCUGUUA

UCUGtJUAG

CUGUUAGC

UGUTJAGCU

AGCUUGCU

GCtTUGCIU

GCUUUAAA

UAAAAAU

AAAAAUUA

AAAAUIJAU

AUUACUGU

tJUACUGUA

ACUGUAAG

CUGUAAGA

AGAAAUAG

GUTJUAUA

UUAUAAAA

UAUAAAAA

AUAAAAAA

UAAAAAAU

UUAAC CAU

AUUAACCA

AUGUCAUU

AAUGUCAU

GUACCUUC

AAUAAAUG

GUACAAUA

GGUACAAU

UGGUACAA

TJUUGGUAC

UGGU1TUGG

ACUCAUAA

AACUCAUA

AAACUCAU

AAAACUCA

UAACAGAA

CUAACAGA

C CUAACAG

AGCUAACA

AGCAAGCU

AAGCAAGC

UUUAAAGC

AAUUUUUA

UAAUUUUEJ

AUAAUUtU

ACAGUAAU

UACAGUAA

CUUACAGU

UCUUACAG

CUAUTJUCU

UAUAAAAC

UUUtJAUAA

UIUUUUAUA

UUU=tJAU

AUUUEIUA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA AAUGAGCA GAA AAAUGAGC GAA ACCAUAAA GAA AACCAUAA GAA AUGUCAJU GAA ACCUUCAA GAA AUGUACCU GAA AAUGUACC GAA AAAUGUAC GAA AUAAAUGU GAA ACAAUAAA GAA AUGGTJUUG GAA AAUGGUU GAA AAAUGGUJ GAA AAAAUGGU GAA ACUCAUAA GAA AACUCAUA GAA AAACUCAU GAA AAAACUCA GAA ACAGAAAA GAA AACAGAAA GAA AGCUAACA GAA AGCAAGCU GAA AAGCAAGC GAA AAAGCAAG GAA AUUUUAA GAA AAULTUTJA GAA AUAATTU GAA AAUAATUU GAA ACAGUAAU GAA AUUUCUUA GAA ACUAUUUC GAA AACUAUTJU GAA AAACUAUJ GAA AAAACUAU Targe SegenceRibozyme Sequence 2705 AGUUUUAU A AAAAAUUA UAAUUUUU CUGAUGA X GAA AUAAAACU a a a a

U

nt.

Posi tion 2712 2713 2715 2717 2718 2719 2720 2721 2723 2724 2728 2731 2732 2733 15 2736 2737 2738 2741 2761 2762 2763 2764 2765 2772 2777 2779 2780 2787 2802 2804 2816 2822 2843 2849 2850 Target Sequence

UAAAAAAU

AAAAAAUJ

AAAAUUAU

AALTUAUAU

ALTUAUAUJ

UTJAUAULU

UAUAUUTU

AUATUULU

AtJUUUUAJ

UTU=JAUU

UAUUCAGU

UCAGUAAU

CAGUAAU

AGUAAUUUJ

AAUUUTAAU

AUJT2AAUU

ULTUAAUUU

AAUUUUGU

AAAAACGU

AAAACGUU

AAACGUUU

AACGUUTU

ACGUUUUU

UUGCUGCU

GCUAUGGU

UAUGGUCU

AUGGUCIU.

UAGCCUGU

CUGCUAGU

GCUAGUAU

GGGGCAGU

GUAGAGCU1

AAGAAACUI

CUUGGUGU 1

UUGGUGLU

JAUAUUUUU

UAUUUUEtA

UUUUUAUU

UTYUAUUCA

UUAUJCAG

UAUTJCAGU

AUUCAGUA

UUCAGUAA

CAGUAAUL

AGUAAUU

AUUUAAUU

UAAXJUUUG

AAtUUU AUUUtJGUA

UUGUAAAU

UGUAAAUG

GUAAAUGC

AAUGCCAA

UUUUGCUG

UUUGCUGC

UUGCUGCU

UGCUGCtJA

GCUGCUAU

UGGUCUUA

IJUAGCCUG

AGCCUGUA

GCCUGUAG

GACAUGCU

UCAGAGGG

AGAGGGGC

GAGCUJGG

GGACAGAA

GGUGUUAG

AGGUAAUJ

GGUAAUUG

AAAALAUAU CUGAUGA UAAAAAt~z

AAUAAAA-Z

UGAAUAALP

CUGAAUAA

ACUGAAUA

UACUGAAU

UUACUGAA

AAUEJACUG

AAAUUACU

AAUUAAAU

CAAAAtJUA

ACAAAAUU

UACAAAAU

AULTUACAA

CAULUACA

GCAUUUAC

UUGGCAUU

CAGCAAAA

GCAGCAAA

AGCAGCAA

UAGCAGCA

AUAGCAGC

UAAGACCA

CAGGCUAA

UACAGGCU

CTJACAGGC

AGCAUGUC

CCCUCUGA

GCCCCUCU

CCAAGCUC

UUCUGUCC

CUAACACC

AAUUACCU

CAAUUACC

CUGAUGA

LCUGAUGA

CUGAUGA

CUGAUGA

*CUGAUGA

*CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CtJGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA AUUUUUUA GAA AAUUUUJT GAA AUAAUUUU GAA AUAUAAUU *GAA AAUAUAATJ *GAA AAAUAUAA GAA AAAAUAUA GAA AAA.AAUAU GAA AUAAAAAU GAA AAUAAAAA GAA ACUGAAUA GAA AUUACUGA GAA AAUUACUG GAA AAAUUACU GAA AUUAAAUU GAA AAUUAAAU GAA AAAUUAAA GAA ACAAAALU GAA ACGUUUUUJ GAA AACGUUUU GAA AAACGUTIJ GAA AAAACGUU GAA AAAAACGU GAA AGCAGCAA GAA ACCAUAGC GAA AGACCAUA GAA AAGACCAU GAA ACAGGCUA GAA ACUACCAG GAA AUACUAGC GAA ACUGCCCC GAA AGCUCUAC GAA AGUUCUU GAA ACACCAAG GAA AACACCAA Ribozyme Sequence 2854 UGUUAGGU A AUUGACUA 2854 UGUUGGU AUUACUAUAGUCAAU CUGAUGA X GAA ACCUAACA *too S0.., nt.

Posi tion 2857 2862 2869 2872 2874 2875 2876 2882 2883 2884 2885 2886 2889 2890 2891 2892 2894 2896 2898 20 2900 2902 2906 2907 2908 290-9 2910 2911 2912 2913 2916 2917 2924 2928 2929 2937 2940 Targ~et Seq~uence

UAGGUAAU

AAUUGACU

UAUGCACU

GCACUAGU

ACUAGUAU

CUAGUAUJ

UAGUAUUU

UUCAGACU

UCAGACU)

CAGACUUU

AGACUUTJ

GACUUUU

UUUUUAAU

UUUTUAAUU

UUUAAUUU

UUAAUUUU

AAUUUUAU

UUTJUAUAU

UUAUAUAU

AUAUAUAU

AUAUAUAU

AUAUACAU

UAUACAUU

AUACAUU

UACAUTJU

ACAUUUUU

CAUUUTU

AUUUTJUUU

UUUUCCLTU

TJCUGCAAU

CAAUACAU

AAUACAUU

UGAAAACU

AAACUUGU

GACUAUGC

UGCACUAG

GUAUTJUCA

UTJUCAGAC

UCAGACUU

CAGACUU

AGACUUU

UUUAAUUU

UUAAUUUU

UAAUUUUA

AAUTJUUAU

ATJUUUAUA

UTJAUAUAU

UAUAUAUA

AUAUAUAU

UAUAUAUA

UAUAUAUA

UAUAUACA

UAUACAUU

UACAUUUU

CAUUUUUU

UUJuuTJC C

UTJUTCCU

U-UUUCCU

TUC CUUC

UUCCUUCU

UCCU.UCUG

CCU-UCUGC

CUUCUGCA

CUGCAAUA

UGCAAUAC

CAUUTJGAA

UGAAAACU

GAAAACUU

GUUUGGGA

UGGGAGAC

G CAUAGUC

CUAGUGCA

UGAAAUAC

GUCUGAAA

AAGUCUGA

AAAGUCUG

AA.AAGUCU

AAAtJUAAA

AAAAUTUAA

UAAAALTUA

AUAAAAUJ

UAUAAAAU

AUAUAUAA

UAUAUAUA

AUAUAUAU

UAUAUAUA

UAUAUAUA

UGUAUAUA

AAUGUAUA

AAAAUGUA

AAAAAAUG

GGAAAAAA

AGGAAAAA

AAGGAAAA

GAAGGAAA

AGAAGGAA

CAGAAGGA

GCAGAAGG

UGCAGAAG

UAUTJGCAG

GUAUUGCA

UUCAAAUG

AGUUUUCA

AAGUUUUC

UCCCAAAC

GUCUCCCA

CUCAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA,

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA AUUACCUA GAA AGUCAAUJ GAA AGUGCAUA GAA ACUAGUOC GAA AUACUAGU GAA AAUACUAG GAA AAAUACUA GAA AGUCUGAA GAA AAGUCUGA GAA AAAGUCUG GAA AAAAGUCU GAA AAAAAGUC GAA AUUAAAAA GAA AAUUAAAA GAA AAAUUAAA GAA AAAAUTUAA GAA AUAAAAUJ GAA AUAUAAAA GAA AUAUAUAA GAA AUAUAUAU GAA AUAUAUAU GAA AUGUAUAU GAA AAUGUAUA GAA AAAUGUAU GAA AAAAUGUA GAA AAAA-AUGU GAA AAAAAAUG GAA AAAAAAAU GAA AAAAAAAA GAA AGGAAAAA GAA AAGGAAAA GAA AUUGCAGA GAA AUGUAUJG GAA AAUGUAUJ GAA AGUUUUCA GAA ACAAGUUU Ribozyme Secquence 9 nt..

Posi tion 2941 2950 2956 2957 2958 2959 2960 2961 2969 2970 2971 2972 2973 2974 2977 2978 2980 2983 2987 2988 2989 2991 3003 3009 3010 3012 3013 3014 3015 3016 3030 3033 3039 3042 3046 3047 Targ t Sequence

AACUUGUU

GGGAGACU

CUCUGCAU

UCUG CAUJ

CUGCAUUU

UGCAUUU

G CAUUUUU

CAUUUUJTJ

AUTJGUGGU

UUGUGGU

UGUGGUUU

GUGGUUUU

UGGTUUU

GGUTUULTU

UUUUUUGU

UUUUUGLU

UUGUJAU

GUTUAUTUGU

UUGUTJGGU

UGUTUGGUJ

GIJUGGUUU

UGGULTtJAU

GCAUGCGU

GUUGCACU

UUGCACUJ

GCACUUCU

CACUTJCUTJ

ACLUJCUUU

CUUjCUuuu

UTJCULUU

AUGUGUGU

UGUGUUGU

GUUGAUGU

GAUGUUCU

UUCUAUGU

UCUAUGLU

GGGAGACU

UGCAUUU

UUUUAUUG

UTJUAUIJGU

UUAUTJGUG

UAUTJGUGG

AUUGUGGU

tIUGUGGUT)

UUJUGUU

UTUIJGUIJA

UTJTGUTJAU

UTJGUUAU

UGUUAUUG

GUTUAUUGU

AUUJGUUGG

UTJGUtJGGU

GUTJGGUUU

GGUUAUA

UAUACAAG

AUACAAGC

UACAAGCA

CAAGCAUG

G CACUUCU

CUUUUUUG

UTUUTTGG

UTJUUGGGA

UUTJGGGAG

UTJGGGAGA

UGGGAGAU

GGGAGAUG

GUtJGAUGU

GAUGUJCU

CUAUGUUU

UGUUUUGU

UUGUUUIJG

TJGUUUUGA

AGUCUCCC

AAAAUGCA

CAAUAAAA

ACAAUAAA

CACAAUAA

CCACAAUA

AC CACAAU

AACCACAA

AACAAAAA

UAACAAAA

AUAACAA

AAUAACAA

CAAUAACA

ACAAUAAC

CCAACAAU

ACCAACAA

AAACCAAC

UAUAAACC

CUTTJGUAUA

GCUUGUAU

UGCUTJGUA

CAUGCUUG

AGAAGUGC

CAAAAAAG

CCAAAAAA

UCCCAAALA

CUCCCAAA

UCUCCCAA

AUCU C CCA

CAUCUCCC

ACAUCAAC

AGAACAUC

AAACAUAG

ACAAAACA

CAAAACAA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

ALACA-AGUU

AGUCUCCC

AUG CAGAG

AAUGCAGA

AAAUGCAG

AA.AAUGCA

AAAAAUG C

AAAAAAUG

ACCACALAU

AACCACAA

AALACCACA

AAAAC CAC

AAAAACCA

AAAAAACC

ACAAAAAA

AACAAAAA

AUAACAAA

ACAAUAAC

ACCAACAA

AACCAACA

A-AAC CAAC

AUAAACCA

ACGCAUGC

AGUG CAAC

AAGUGCAA

AGAAGUG C

AAGAAGUG

AAAGAAGU

AAAAGAAG

AAAAAGAA

ACACACAU

ACAACACA

ACAUCALAC

AGAACAUC

ACAUAGAA

Targe SeqenceRibozyme Seq~uence UCAAAACA CUGAUGA X GAA AACAUAGA a a.

a a a a a a a nt.- Position 3048 3051 3052 3053 3060 3071 3072 3073 3074 10 3076 3079 3080 3087 3094 15 3095 3099 3105 3115 3116 3117 3119 3125 3130 3132 3141 3150 3157 3158 3185 3189 3196 3204 3205 3213 3214 3240 Target Sequence CUAUGUUUt

UGUTJUGU

GUUUtJGUU UtJUGUUU

UUGAGUGU

CUGACUGU

UGACUGTU

GACUGUUTJ

ACUGUtUU

UGUUTJUAU

UTJUAUAAU

UIJAUAAUUt

UUGGGAGU

UUCUGCAU

UCUGCAUU

CAUUUIGAU

AUCCGCAU

CCUGUGGU

CUGUGGUTJ

UGUGGUUU

UGGUUUCU

CUAAGUGU

UGUAUGGU

UAUGGUCU

AGAACUGU

GCAUGGAU

UCCUGUGU

CCUGUGUU

ACUGUGGU

UGGUUGAU

UAGCCAGU

CACUGCCU1

ACUGCCUU

AAGAACAU 1 AGAACAUU 1 ACUGAACU 1

GUUUGAG

UIJGAGUGU

UGAGUGUA

GAGUGUAG

GCCUGACU

UUAUAAUTJ

UAUAAUUJI

AUAAUTUUG

UAAUUUGG

ATJUUGGGA

UGGGAGUU

GGGAGUUC

CUGCAULU

UGAUCCGC

GAUCCGCA

CGCAUCCC

CCCUGUGG

UCUAAGUG

CUAAGUGU

UAAGUGUA

AGUGUAUG

UGGUCUCA

UCAGAACU

AGAACUGU

GCAUGGAU

CUGUGUUU

UGCAACUG

GCAACUGG

GAUAGCCA

GCCAGUCA

ACUGCCUTJ

AAGAACAU

AGAACAUU

UGAUGCAA

GAUGCAAG

UUGAGAUA

CUCAAAAC

ACACUCAA

UACACUCA

CUACACUC

AGUCAGGC

AAUUAUAA

A.AAUUAUA

CAAAUTUAU

CCA.AAUTUA

UCCCAAAU

AACUCCCA

GAACUCCC

AAAUGCAG

GCGGAUCA

UGCGGAUC

GGGAUGCG

CCACAGGG

CACUUAGA

ACACUUAG

UACACUUA

CAUACACU

UGAGACCA

AGUIJCUGA

ACAGUUCU

AUCCAUGC

AAACACAG

CAGUTJGCA

CCAGUUGC

UGGCUAUC

UGACUGGC

AAGGCAGU

AUGUtJCUU

AAUGUUCU

UUGCAUCA

CIJUGCAUC

UAtJCUCAA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA AAACAUAG GAA ACAA.AACA GAA AACAAAAC GA-A AAACAAAA GAA ACACUCAA GAA ACAGUCAG GAA AACAGUCA GAA AA.ACAGUC GAA AAAACAGU GAA AUAAAACA GAA AUIJAUAAA GAA AAUUAUAA GAA ACUCCCAA GAA AUGCAGAA GAA AAUGCAGA GAA AUCAAAUG GAA AUG CGGAU GAA ACCACAGG GAA AACCACAG GAA AAACCACA GAA AGAAACCA GAA ACACUUAG GAA ACCAUACA GAA AGACCAUA GA7A ACAGUUCU GAA AUCCAUGC GAA ACACAGGA GAA AACACAGG GAA ACCACAGU GAA AUCAACCA GAA ACUGGCUA GAA AGGCAGUG GAA AAGGCAGU GAA AUGUUCUJ GAA AAUGUUCU GAA AGUUCAGU Ribozymre Sequence nt.

Position 3241 3242 3248 3258 3261 3262 3269 3272 3280 10 3293 3294 Target Sequence Ribozyne Sequence

CUGAACUU

UGAACUIU

UTJUGAGAU

GACGGUGU

GGUGUACU

GUGUACUU

UACUG ccU

UGCCUUGU

AGCAAAAU

UGUGCCCU

GUGCCCUU

U UGAGAUAU U GAGAUAUG A UGACGGUG A CUUACtJGC U ACUGCCUU A CUGCCUJG U GUAGCAAA A GCAAAAUA A AAGAtJGUG U AUUUUACC A UTIJACCU

AUAUCUCA

CAUAUCUC

CACCGUCA

GCAGUAAG

AAGGCAGU

CAAGGCAG

UTJUGCUAC

UAUUUUGC

CACAUCUJ

GGUAAAAU

AGGUAAAA

CUGAUGA X GAA AAGtJUCAG CUGAUGA X GAA AAAGUTJCA CUGAUGA X GAA AUCUCAAA CUGAUGA X GAA ACACCGUC CUGAUGA X GAA AGUACACC CUGAUGA X GAA AAGUACAC CUGAUGA X GAA AGGCAGUA CUGAUGA X GAA ACAAGGCA CUGAUGA X GAA AUUUUGCU CUGAUGA X GAA AGGGCACA CUGAUGA X GAA AAGGGCAC

S

S S. S S S

S

Where IIX" represents stem II region of a HH ribozyme (Hertel -et al., 1992 Nucleic Acids Res. 20 3252). The 15 length of stem II may be 2: 2 base-pairs.

Table XV: Mouse c-mvb Hammerhead Ribozyme and Target Seqruence nt.

20 Position 12 33 63 93 113 134 145 149 160 231 234 241 Target Seqruence RibozVme Sequence CcGGGGcUc

GGGGCUCUU

GCCCGCCUC

CACAGCAUC

CAGCAUCUA

UCUACAGUA

GAAGACAU

CCAUGACUA

GCCCAAAUC

GAAAGCGUC

GCGUCACUU

GGAAAACUA

UGGAAAGUC

AAAGUCALU

LTTJGCCAAUU

UUGGCGGA

GGCGGAGC

GCCAUGGC

UACAGUAG

CAGUAGCG

GCGAUGAA

GAGAUGUG

CGAUGGGC

UGGAAAGC

ACUUGGGG

GGGGAAAA

GGUGGACA

AUTUGCCAA

GCCAAUTUA

AUCUGCCC

UCCGCCAA cUGAUGA X GAA AGCCCCGG

GCUCCGCC

GCCAUGGC

cUAcUGUA cGcUACUG

UUCAUCGC

CACAUCUC

GcccAUCG Gcuuuc cA CCC CAAGU uuuuccc c

UGUCCACC

LUJGGCAAU

UAAUUGGC

GGGCAGAU

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

X GAA X GAA X GAA X GAA X GAA X GAA X GAA X GAA X GAA X GAA X GAP.

X GAP.

X GAP.

X GAA

AGAGCCCC

AGGCGGGC

AUGCUGUG

AGAUGCUG

ACUGUAGA

AUGUCUUC

AGUCAUGG

AUUUGGGC

ACG CUTUC

AGUGACGC

AGUUtJUCC

ACUUCCA

AUGACUUU

AUIJGGCAA

4S a.

a a S. S.

nt.

Position 242 244 264 306 309 316 337 345 348 10 354 357 365 370 379 15 383 387 388 390 401 402 414 427 448 449 454 462 463 473 498 501 502 503 520 543 571 577 Target Sequence UG CCAAUJA C CAAUUAUC

ACAGAUGUA

CCUGAACUC

GAACUCAUC

UCAAAGGUC

A-AGAAGAUC

CAGAGAGUC

AGAGUCAUA

AUAAAGCUJ

AAGCUUGUC

CCAGAAAUA

AAUAUGGUC

CGAAGCGUU

GCGUTJGGUC

UGGUCUGUU

UCUGCCCA

UGCCCAAC

CAGUGCCA

AUCAAAGG

AAAGGUCC

C CUGGACC

AGAGAGUC

AUAAAGCU

AAGCUUGU

GUCCAGAA

CAGAAAUA

UGGUCCGA

CGAAGCGU

GGUCUGU

UGUTJAUUG

ALTUGCCAA

GGUCUGUUA UUGCCAAG UCUGUUAUU GCCAAGCA CAAGCACIJU AAAAGGGA AAGCACUUA AAAGGGAG GGGAGAAUTJ GGAAAGCA AG CAGUGUC GGGAGAGG ACAACCAUU UGAAUCCA CAACCAUTJ GAAUCCAG AUUUGAAUC CAGAAGUU C CAGAAGTJU AAGAAAAC CAGAAGUUA AGAAAACC GAAAACCUC CUGGACAG GACAGAAUC AUUUACCA AGAAUCAUU UACCAGGC GAAUCAUUU ACCAGGCA A-AUCAUTJA CCAGGCAC ACAAGCGUC UGGGGAAC GCAGAGAUC GCAAAGCU GGACUGAUA AUGCUAUC AUAAUGCUA UCAAGAAC UGGG CAGA

GUUGGGCA

UGG CACUG

CCUUUGAU

GGACCUU

GGUCCAGG

GACUCUCU

AGCUUUAU

ACAAGCUU

UUCUGGAC

UAUUUCUG

UCGGACCA

ACG CUUCG

AACAGACC

CAAUAACA

UUGGCAAU

CUTUGGCAA

UGCUUGGC

UCCCUUUU

CUccUU-U

UGCUUUCC

CcUCcCC

UGGAUUCA

CUGGAUUC

AACUTJCUG

GUTTUCUU

GGUUUUCU

CUGUCCAG

UGGUAAAU

GCCUGGUA

UGCCUGGU

GUGCCUGG

GUUCCCCA

AGCUUUGC

GAUAGCAU

GtYUCUUGA CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X Targe Seqence Ribozyme Sequence GAA AATJUGGCA GAA AUAAUUGG GAA ACAUCUGU GAA AGUIJCAGG GAA AUGAGUTIC GAA ACCUUUGA GAA AUCUUCUU GAA ACUCUCUG GAA AUGACUCU GAA AGCUUUAU GAA ACAAGCUJ GAA AUIJUCUGG GAA ACCAUAUU GAA ACGCUUCG GAA ACCAACGC GAA ACAGACCA GAA AACAGACC GAA AUAACAGA GAA AGUGCUTJG GAA AAGUGCUU GAA ALTUCUCCC GAA ACACUGCU GAA ATJGGUUGU GAA AAUGGUUG GAA AUUCAAAU GAA ACUUCUGG GAA AACUUCUG GAA AGGUTJUUC GAA AUUCUGUC GAA AUGAUUCU GAA AAUGAUTJC GAA AAAUGAUU GAA ACGCUUGU GAA AUCUCUGC GAA AUCAGUCC GAA AGCAUUAU 0 0* a.

0* 0 0O *0 0

S

nt.

Position 579 595 596 607 629 643 644 677 678 10 691 694 695 704 705 15 716 721 725 727 732 734 736 749 752 756 767 769 773 775 776 783 801 803 808 813 814 818 Target Sequence

AAUGCUAUC

ACUGGAAUU

CUGGAAUIJC

CCAUGCGUC

GGAAGGCUA

AGAAGCCUU

GAAGCCUTUC

CACGAGCUU

ACGAGCUJC

AGAACAAUC

ACAAUCAUU

CAAUCAUUU

GAUGGGGUIJ

AUGGGGUUU

GCAUGCCUC

CCUCACCUC

ACCUCCAUC

CUCCAUCUC

UCUCAGCUC

UCAGCUCUC

AGCUCUCUC

UGGCCAGUC

CCAGUCCUC

UCCUCCGUC

CAGCGAAUA

GCGAAUAUC

AUAUCCCUA

AUCCCUAUU

UCCCUAUUA

UACCACAUC

CAAAACAUC

AAACAUCUC

UCUCCAGUC

AGUCACGUU

GUCACGtJUC

CGUUCCCUA

AAGAACCA

CCACCAUG

CACCAUGC

GCAAGGUG

CCUGCAGA

C CAAAG CC

CAAAGCCA

CCAGAAGA

CAGAAGAA

AUUtUGAUG

UGAUGGGG

GAUGGGGU

UGGGCAUG

GGGCAUGC

ACCUCCAU

CAUCUCAG

UCAG CUCU

AGCUCUCU

UCUCCAAG

UCCAAGUG

CAAGUGGC

CUCCGUCA

CGUCAACA

AACAGCGA

UCCCUAUU

CCUAUUAC

UUACCACA

AC CACAU C

CCACAUCG

GCCGAAGC

UCCAGUCA

CAGUCACG

ACGUJC C C

CCCUAUCC

CCUAUCCU

UCCUGUCG

UGGUJECUU

CAUGGUGG

GCAUGGUG

CACCUUGC

UCUGCAGG

GGCUTJUGG

UGG CUUUG

UCUUCUGG

UUCUUCUG

CAUCAAAU

CCCCAUCA

ACCCCAUC

CAUGCCCA

GCAUGCCC

AUGGAGGU

CUGAGAUG

AGAGCUGA

AGAGAGCU

CUUGGAGA

CACUUGGA

GCCACUUG

UGACGGAG

UGtJUGACG

UCGCUGUU

AAUAGGGA

GUAAUAGG

UGUGGUAA

GAUGUGGU

CGAUGUGG

GCUUCGGC

UGACUGGA

CGUGACUG

GGGAACGU

GGAUAGGG

AGGAUAGG

CGACAGGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA AUAGCAUU GAA AUUCCAGU GAA AAUUCCAG GAA ACGCAUGG GAA AGCCUUCC GAA AGGCUUCU GA.A AAGGCUUC GAA AGCUCGUG GAA AAGCUCGU GAA AUUGUUCU GAA AUGAUUGU GAA AAUGAUUG GAA ACCCCAUC GAA AACCCCAU GAA AGGCAUGC GAA AGGUGAGO GAA~ AUGGAGGU GAA AGAUGGAG GAA AGCUGAGA GAA AGAGCUGA GAA AGAGAGCU GAA ACUGGCCA GAA AGGACUGO GAA ACGGAGGA GAA AUUCGCUG GA.A AUAUUCGC GAA AGGGAUAU GAA AUAGGGAU GAA AAUAGGGA GA-A AUGUGGUA GAA AUGUUUUG GAA AGAUGUUJ GAA ACUGGAGA GAA ACGUGACU GAA AACGUGAC GAA AGGGAACG Ribozyne Sequence a. *e 0 0 a a 000000 0 p.

p p

S*

p p p p. p p. p.

p nt.* Position 820 825 830 837 838 841 843 846 852 10 856 876 887 889 921 935 939 947 980 981 1000 1007 1028 1032 1051 1060 1071 1072 1073 1078 1079 1103 1105 1117 1124 1128 1145 Target Sequence p.

app.

p

P.S.

p pp pp p p p

S

p

UUCCCUAUC

UAUC CUGUC

UGUCGCAUI

UUGCAUGULC

UGCAUGUU.

AUGUTJAAU.A

GUTJAAUAUA

AAUAUAGUC

GUCAACGUC

ACGUCCCUC

GCAGCCAUC

GAGACACUA

GACACUAUA

AAGCGAAUA

GCUGGAGUU

GAGUUGCUC

CCUGAUGUC

GCAGGCAUJ

CAGGCAUJA

ACCACACUU

UUGCAGCUA

CAGCACCUC

ACCUCCAUU

CCAGACCUC

AUGGGGAUA

GCACCUGUJ

CACCUGUU

ACCUGUJUC

UUUCCUG-U

UUCCUGU-U

CACCC CAUC CC CCAUCUC

CUGCAGAUC

UCCCGGCUC

GGCUCCCUA

AAGUGCCUC

CUGUCGCA

GCAUUGCA

I GCAUGUUtA

TAAUAUAGU

AUAUAGUC

UAGUCAAC

GUCAACGU

AACGUCCC

CCUCAGCC

AGCCGGCU

CAGAGACA

UAACGACG

ACGACGAA

AAGGAGCU

GCUCCUGA

CUGAUGUC

AACAGAGA

ACCAACAC

CCAACACA

GCAGCUAC

CCCCGGGU

CAUtJGUGG

GUGGACCA

AUGGGGAU

GUGCACCU

UCCUGUUUT

CCUGUUJG

CUGUUUGG

UGGGAGAA

GGGAGAAC

UCUGCCUG

UGCCUGCA

CCGGCUCC

CCUACCUG

CCUGAAGA

ACCAGCAA

UGCGACA(

UGCAAUG(

UAACAUG(

ACUAUAUT

GACUAUAI

GUUGACUI

AC GUUGA C

GGGACGUL

GGCUGAGC

AGCCGGCIL

UGUCUCUG

CGUCGUUA

tJUCGUCGU

AGCUCCUU

UCAGGAGC

GACAUCAG

UCUCUGU

GUGUUGGU

UGUGUUGG

GUAGCUGC

ACCCGGGG

CCACAAUG

UGGUCCAC

AUCCCCAU

AGGUGCAC

AAACAGGA

CAAACAGG

CCAAACAG

UUCUCCCA

GUUCUCCC

CAGG CAGA

UGCAGGCA

GGAGCCGG

CAGGUAGG

UCUUCAGG

UUGCUGGU

3 CUGAUGA

CUGAUGA

CUGAUGA

J CUGAUGA J CUGAUGA

CUGAUGA

CUGAUGA

JCUGAUGA

;CUGAUGA

rCUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAtJGA Ribozyne Sequence K GAA AUAGGGAA K GAA ACAGGAUA KGAA AUG CGACA KGAA ACAUGCAA GAA AACAUGCA GAA AUIJAACAU GAA AUAUTJAAC GAA ACUAUAUTJ GAA ACGUTJGAC GAA AGGGACGU GAA AUGGCUGC GAA AGUGUCUC GAA AUAGUGUC GAA AUUCGCUU GAA ACUCCAGC GAA AGCAACUC GAA ACAUCAGG GAA AUGCCUGC GAA AAUGCCUG GAA AGUGUGGU GAA AGCUGCAA GAA AGGUGCUG GAA AUGGAGGU GAA AGGUCUGG GAA AUCCCCAU GAA ACAGGUGC GAA AACAGGUG GAA AAACAGGU GAA ACAGGAAA GAA AACAGGAA GAA AUGGGGUG GAA AGAUGGGG GAA AUCUGCAG GAA AGCCGGGA GAA AGGGAGCC GAA AGGCACUU a.

a nt.

Position 1164 1167 1182 1183 1194 1195 1203 1205 1206 10 1211 1212 1224 1229 1230 1231 1233 1237 1238 1240 20 1241 1242 1244 1252 1253 1271 1277 1278 1288 1292 1293 1298 1303 1306 1308 1311 1315 Target Seauence UCCAUGAUC GUCCACCA AUGAUCGUC CACCAGGG GGCACCAUU CUGGACAA GCACCAUJC UGGACAAU GACAAUGUTJ AAGAACCU ACAAUGUUA AGAACCUC AAGAACCUC LTUAGAAUU GAACCUCUU AGAAUTJUG AACCUCUUA GAAUUUGC

CUUAGAAUU

UUAGAAUUU

GAAACACUC

ACUCCAGUU

CUCCAGUTJD

UCCAGUUUA

CAGUUUTAUA

UUAUAGAUTJ

UAUAGAUUC

UAGAUUCUJ

AGAUUTCUTU

GAUUCUUTJC

uucu-uucUU

UGAACACUU

GAACACUUC

UGAAAACUC

CUCGGGCUTJ

UCGGGCUTJA

AUG CAC CUA

ACCUACCUJ

CCUACCUUA

CUUACCCUC

CCUCCACUC

CCACUCCUC

ACUCCUCUC

CCUCUCAUEJ

UCAtJUGGUC

UGCAGAAA

GCAGAAAC

CAGUUUAU

UAUAGAUTJ

AUAGAUUC

UAGAUUCU

GAtJUCUUU

CUTJUCUTJG

UUIJCUUGA

UCUUGAAC

CUUGAACA

UUGAACAC

GAACACUU

CCAGCAAC

CAGCAACC

GGGCUTJAG

AGAUG CAC

GAUGCACC

CCUTJACCC

ACCCUCCA

CCCUCCAC

CACUCCUC

CUCUCAUU

UCAUUGGU

AUUGGUCA

GGUCACAA

ACAAACUG

Ribozyme Sequence UGGUGGAC CUGAUGA X CAA ALJCAUGCA CCCUGGUG CUGAUGA X GA-A ACGAUCAU UUGUCCAG CUGAUGA X GAA AUGGUGCC AUUGUCCA CUGAUGA X GAA AAUGGUGC AGGTJUCUU CUGAUGA X GAA ACAUUGUC GAGGUUCU CUGAUGA X GAA AACAUUGU AAUUCUAA CUGAUGA X GA-A AGGUIJCUU CAAAUUCU CUGAUGA X GAA AGAGGUUC GCAAAUUC CUGAUGA X GAA AAGAGGUU =UUCUGCA CUGAUGA X GAA AUTJCUAAG GUTJTCUGC CUGAUGA X GAA AAUUCtJAA AUAAACUG CUGAUGA X GAA AGUGULUJC AAUCUAUA CUGAUGA X GAA ACUGGAGU GAAUCUAU CUGAUGA X GAA AACUGGAG AGAAUCUA CUGAUGA X GAA AAACUGGA AAAGAAUC CUGAUGA X GAA AUAAACUG CAAGAAAG CUGAUGA X GAA AUCUAIJAA UCAAGAAA CUGAtJGA X GAA AAUCUAUA GUtJCAAGA CUGAUGA X GAA AGAAUCUA UGUUCAAG CUGAUGA X GAA AAGAAUCU GUGUUCAA CUGAUGA X GAA AAAGAAUC AAGUGUUC CUGAUGA X GAA AGAAAGAA GUUGCUGG CUGAUGA X GAA AGUGIJUCA GGUUGCUG CUGAUGA X GAA AAGUGUUC CUAAGCCC CUGAUGA X GAA AGUtJUUCA GUGCAUCU CUGAUGA X GAA AGCCCGAG GGUGCAUC CUGAUGA X GAA AAGCCCGA GGGUAAGG CUGAUGA X GAA AGGUGCAU UGGAGGGU CUGAUGA X GAA AGGUAGGU GUGGAGGG CUGAUGA X GAA ALAGGUAGG GAGGAGUG CUGAUGA X GAA AGGGUAAG AAUGAGAG CUGAUGA X GAA AGUGGAGG ACCAAUGA CUGAUGA X GAA AGGAGUGG UGACCAAU CUGAUGA X GAA AGAGGAGU UUGUGACC CUGAUGA X GAA AUGAGAGG CAGUUUGU CUGAUGA X GAA ACCAAUGA nt.

Position 1333 1366 1367 1371 1373 1374 1375 1381 1387 1389 1397 1401 1404 1412 1414 1417 1423 1433 1434 20 1446 1453 1461 1462 1466 1471 1485 1489 1499 1518 1530 1531 1541 15S0 1557 1560 1568 Target Sequence CAC CAUGUC

AGGAAAAUU

GGAAAALUC

AAUTJCCAUC

UIJCCAUCUU

UCCAUCUTU

CCAUCUUUA

UTUAGAACUC

CUCCAGCUA

CCAG CUAUC

CAAAAGGUC

AGGUCAAUC

UCAAUCCUC

CGAA~AGCUC

AAAGCUCUC

GCUCUCCUC

CUCGAACUC

CACACCAUU

ACACCAUTJC

CAUGCCCUU

UUGCAGCUC

CAAGAAALU

AAGAAAUUA

AALTUAAAUA

AAUACGGUC

AAGAUGCUA

UGCUACCUC

GACCCCCUC

GAGGACCUA

GAUGUGAtU

AUGUGAUTJA

GCGGGAAUC

GGAUGAAUC

UCUGGAAUU

GGAAUUGUU

UGCUGAGUTJ

GAGACCAG

CCAUCUUJ

CAUCUUJA

UUUAGAAC

UAGAACUC

AGAACUCC

GAACUCCA

CAGCUAUC

UCAAAAGG

AAAAGGUC

AAUCCUCG

CUCGAAAG

GAAAGCUC

UCCUCGAA

CUCGAACU

GAACUCCC

CCACACCA

CAAACAUG

AAACAUGC

GCAGCUCA

AAGAAAU

AAAUACGG

AAUACGGU

CGGUCCCC

CCCUGAAG

CCUCAGAC

AGACCCCC

CCAUGCAG

CAAGAUGU

AAGCGGGA

AGCGGGAA

GGAUGAAU

UGGAAUTJG

GUTJGCUGA

GCUGAGUU.

UCAAGAGA

CUGGUCUC CUGAUGA X GAA ACAUGGUG

AAAGAUGG

UAAAGAUG

GUU)CUAAA

GAGTJUCUA

GGAGUUCU

UGGAGUUC

GAUAGCUG

CCUTJUUGA

GACCUUTUU

CGAGGAUTJ

CIUTJCGAG

GAGCUUC

UUCGAGGA

AGUTJCGAG

GGGAGUUC

UGGUGUGG

CAUGUUUTG

GCAUGUUU

UGAGCUGC

AAUUUCUU

CCGUAUTU

ACCGUAUU

GGGGACCG

CUUCAGGG

GUCUGAGG

GGGGGUCU

CUGCAUGG

ACAUCUTJG

UCCCGCUU

UUCCCGCU

AtJUCAUCC

CAATJUCCA

UCAGCAAC

AACUCAGC

UCUCUUGA

CUGAUGA

CUGAUGA

CUGAUGA

CtGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA AUUTJUCCU GAA AAUTJCC GAA AUGGAATJI GAA AGAUGGAA GAA AAGAUGGA GAA AAAGAUGG GAA AGTJUCUAA GAA ACCUGGAG GAA AUAGCUGG GAA ACCTUTJUG GA-A AUUGACCU GAA AGGAUUGA GAA AGCUTJUCG GAA AGAGCUUU GAA AGGAGAGC GAA AGUUCGAG GAA AUGGUGUG GAA AAUGGUGU GAA AGGGCAUG GAA AGCUGCAA GAA AUUUCUUG GAA AAUUUCUU GAA AUTJUAAUUJ GAA ACCGUAUU GAA AGCAUCUTJ GAA AGGUAGCA GAA AGGGGGUC GAA AGGUCCUC GAA AUCACAUC GAA AAUCACAU GAA AUUCCCGC GAA AUTJCAUCC GAA AUUCCAGA GAA ACAAUTJCC GAA ACUCAGCA Ribozvme Sequence nt. Target Sequence Posi- Ribozvme Seauence to.

tion 1569 1570 1589 1590 1602 1619 1634 1643 1644 1646 1647 1652 1691 1692 1694 1703 1705 1726 1728 20 1729 1731 1732 1739 1743 1744 1745 1746 1758 1760 1779 1782 1790 1791 1792 1797 1801 G CUGAGUU

CUGAGULTUC

ACCACCGU

CCACCGUJA

AAAA.AAAUC

GGUGGAGUC

UGAGAAAUC

GGGAAACUU

GGAAACUUC

AAACUUCUU

AACT-TUCUJC

CUUCUGCUC

CCAI4CUGUU

CAACUGUJC

ACUGUUCUC

GCAGGCGUC

AGGCGUCUC

CCC CAAAUA

CCAAAUALU

CAAAUAUJC

AAUAUUCUU

AUAUUCUUA

UACAAGCUC

AGCUCUGU

GCUCUGUUU

CUCUGUUU

UCUGUUUA

ACAC CUGUA

ACCUGUAUC

GACAAUGUC

AAUGUC CU C

CAAAGCCUU

AAAGCCUUU

AAGCCUUUA

UUUACCGUA

CCGUACCUA

CAAGAGAG

AAGAGAGU

ACUGAAAA

CUGAAAAA

AAGCAGGC

GCCAACUG

GGGAAACU

CUUCUG CU

UUCUGCUC

CUGCUCAA

UGCUCAAA

AAACCACU

CUCGCAGG

UCGCAGGC

GCAGGCGU

UCCUGUGG

CUGUGGCA

UUCUUACA

CUUACAAG

UUACAAGC

ACAAGCUC

CAAGCUCU

UGUUUUAA

UUAAUGAC

UAAUGACA

AAUGACAC

AUGACACC

UCAGAAGA

AGAAGAUG

CUCAAAGC

AAAGCCU

UACCGUAC

AC CGUAC C

CCGUACCU

CCUAAGAA

AGAACAGG

CUCUCUUG

ACUCUCUU

UTJUUCAGU

UUUUUCAG

GCCUGCUU

CAGUUGGC

AGUUCCC

AGCAGAAG

GAG CAGAA

UUGAGCAG

UTJUGAGCA

AGUGGUUU

CCUGCGAG

GCCUGCGA

ACGCCUGC

CCACAGGA

UGCCACAG

UGUAAG.AA

CUrJGUAAG

GCUUGUAA

GAGCUUGU

AGAGCUUG

UUAAAACA

GUCAUUAA

UGUCAUUA

GUGUCAUU

GGUGUCAU

UCUUCUGA

CAUCU'UCU

GCUUUGAG

AAGGCUUU

GUACGGUA

GGUACGGU

AGGUACGG

UUCUTUAGG

CCUGUUCU

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAEJGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA AACUCAGC GAA AAACUCAG GAA ACGGUGGU GAA AACGGUGG GAA AUTUUUUU GAA ACUCCACC GAA AUUUCUCA GAA AGTJUUCCC GAA AAGUUUCC GAA AGAAGUUU GAA AAGAAGUU GAA AGCAGAAG GAA ACAGUIJGG GAA AACAGUUG GAA AGAACAGU GAA ACGCCUGC GAA AGACGCCU GAA AUUUGGGG GAA AUAUUUGG GAA AAUAUUTUG GAA AGAAUAU GAA AAGAAUAU GAA AGCUTJGUA GAA ACAGAGCU GAA AACAGAGC GAA AAACAGAC GAA AAAACAGA GAA ACAGGUGU GAA AUACAGGU GAA ACALTUGUC GAA AGGACAUU GAA AGGCUUUG GAA AAGGCUU GAA AAAGGCUU GAA ACGGUAAA GAA AGGUACGG

S

*S 55 S S nt.

Position 1822 1826 1859 1892 1897 1903 1910 1922 1923 1925 1930 1936 1941 1953 1954 1955 19 67 1968 1973 20 1974 1975 1976 1985 1986 1992 1997 1998 1999 2011 2014 2028 2052 2053 2054 2057 2063 Target Sequence

UGGUGGGUC

GGGUCCCUU

GCCAGCAUC

GACGGCCUC

CCUCCGGUC

GUCCGGCUC

UCGGAAAUA

GAACGCGUU

AACGCGUJC

CGCGUIJCUC

UCUCAGCUC

CUCGAACUC

ACUCUGGUC

UGAGACAUJ

GAGACAUUU

AGACAUUUC

AAAAGCALU

AAAGCAUUTA

AUUAUGGU

UUAUGGUUJ

UAUGGUUUU

AUGGUUUUC

AGAACACUU

GAACACUUA

LTUAAAAGLTU

AGUUGACUJ

GUUGACUUU

UUGACUUUC

ACAUGGCUC

UGGCUCCUC

GGAGCGCUC

AGCCUGAUU

GCCUGAUUU

CCUGAUUU

GAUIJUUGUU

GtIUGUGGUA C CUUGCAG

GCAGCCAU

CUGUGGGA

CGGUCCGG

CGGCUCGG

GGAAAUAC

CGUGAACG

CUCAGCUC

UCAGCUCG

AGCUCGAA

GAACUCUG

UGGUCAUG

AUGUGAGA

UCCAGAAA

CCAGAAAA

CAGAAAAG

AUGGUUUU

UGGUTJUC

UUCAGAAC

UCAGAACA

CAGAACAC

AGAACACU

AAAAGUUG

AAAGUJGA

GACUUJCG

UCGACACA

CGACACAU

GACACAUG

CUCAGCGU

AGCGUGGA

CAUGGCUG

UUGUUGUG

UGUUGUGG

GUUGUGGU

GUGGUACA

CAACAGUU

CUGCAAGG

AUGGCUGC

UCCCACAG

CCGGACCG

CCGAGCCG

GUAUUCC

CGUUCACG

GAGCUGAG

CGAGCUGA

UUCGAGCU

CAGAGTJUC

CAUGACCA

UCUCACAU

UtJUCUGGA

UUUTJCUGG

CUUUUCUG

AAAACCAU

GAAAACCA

GUUCUGAA

UGUUCUGA

GUGUUCUG

AGUGUUCU

CAACUULU

UCAACUU

CGAAAGUC

UGUGUCGA

AUGUGUCG

CAUGUGUC

ACGCUGAG

UCCACGCU

CAGCCAUG

CACAACAA

CCACAACA

ACCACAAC

UGUACCAC

AACUGUUG

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CTUGAUGA

GAA

GAA

GAA

GAA

GA.A

GAA

GA.A

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GA.A

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

ACCCACCA

AGGGACCC

AUGCUGGC

AGGCCGUC

ACCGGAGG

AGCCGGAC

AUIJUCCGA

ACGCGUTJC

AACGCGUU

AGAACG CG AG CUGAGA

AGTJUCGAG

ACCAGAGU

AUGUCUCA

AAUGUCUC

AAAUGUCU

AUGCUUUU

AAUGCUUU

AC CAUAAU

AACCAUAA

AAACCAUA

AAAACCAU

AG UGUUJCU

AAGUGUUC

ACUTJEJEAA

AGUCAACU

AAGU GAlAC

AAAGUCAA

AGCCAUGU

AGGAGCCA

AGCGCUCC

AUCAGGCU

AAUCAGGC

AAAUCAGG

ACAAAAUC

ACCACAAC

Targe Seqence Ribozvme Seallence nt Position 2071 2092 2093 2094 2095 2096 2099 2103 2109 2111 2115 2119 2120 2121 2130 2139 2140 2141 2142 20 2143 2144 2145 2146 2147 2148 2154 2157 2160 2167 2173 2175 2176 2180 2184 2185 2187 Target Seqruence ACAACAGUU GAGAGCAG AAGUGCAUU UTJUAGUTJG AGUGCAUUTU UUAGTJUGC GUGCAUUUU UAGUTJGCU UGCAUUUUU AGUUGCUU GCAUUUTJTA GTJUG CUUG UUTJUUAGUU GCUTJGAGA UAGUIJGCUU GAGAUCUC CUUGAGAUC UCACUUGA UGAGAUCUC ACUUGAUU AUCUCACUU GAU=UCAC CACUUGAUU UCACACAA ACUUGAUTJU CACACAAC CUUGAUUEUC ACACAACU ACACAACUA AAAAGGAU AAAAGGAUU UUtUUUUU AAAGGAUUU UUUUUUUA AAGGAUUtJU UUUTJUUAA AGGAUUUUU UUUUAAA GGAUUUEUU UUUUAAAA GAUTJUUUUTU UUUAAAAA AUUUUUUUU UUAAAAAU tIUUtU~tUU UAAAAAUA UUTLUUUEUU AAAAAUAA UTUUJTUUUA AAAAUAAU UTUAAAAAUA AUAAUAATJ AAAAUAAUA AUAAUGAA AUAAUAAUA AUGAAUAA UAAUGAAUA ACAGUCtU AUAACAGUC UUACCUA.A AACAGUCUU ACCUAAAU ACAGUCUUA CCUAAAUU UCUUACCUA AAUUAUUA ACCUAAAUU AUTJAGGUA CCUAAAUTUA UUAGGUAA UAAAUUAUU AGGUAAUG

CUGCUCUC

CAACUAA

G CAACUAA

AGCAACUA

AAGCAACU

CAAGCAAC

UCUCA.AGC

GAGAUCUC

UCAAGUGA

AAUCAAGU

GUGAAAUC

UUGUGUGA

GUTJGUGUG

AGUTJGUGU

AUCCUUUU

AAAAAAA

UUAAAAAA

UUUAAAA

UUUUAAA

TUULTJUAA

AUUUEUA

UAUUtUU

UUAUUUU

AUUAUUAU

UTJCAUUAU

UUAUUCAU

AAGACUGU

UUAGGUAA

AUUUAGGU

AAUUUAGG

UAAUAAUU

UACCUAAU

UUACCtJAA

CALTUACCU

CUGAUGA X GALA ACUGUUGU CUGAUGA X GALA AUG CACUU CUGAUGA X GALA ALAUGCACU CUGAUGA X GAA AAAUGCAC CUGAUGA X GAA AAAAUGCA CUGAUGA X GAA AAAAAUGC CUGAUGA X GAA ACUAAAAA CUGAUGA X GAA AGCAACUA CUGAUGA X GAA AUCUCAAG CUGAUGA X GAA AGAUCUCA CUGAUGA X GAA AGUGAGAD CUGAUGA X GAA AUCAAGUG CUGAUGA X GAA AAUCAAGU CUGAUGA X GAA AAAUCAAG CUGAUGA X GAA AGUUGUGU CUGAUGA X GAA AUCCUUUU CUGAUGA X GAA AAUCCUUU CUGAUGA X GAA AALAUCCTU CUGAUGA X GAP. AAAAUCCU CUGAUGA X GAP. AAAAAUCC CUGAUGA X GA. AAAAALAUC CUGAUGA X GAP. AAAAAAAU CUGAUGA X GAA AAAPAAAA CUGAUGA X GAA AAAAAAAA CUGAUGA X GAA AAAAAAAA CUGAUGA X GALA AUUUUUAA CUGAUGA X GAA AUUAUUtU CUGAUGA X GA. AUUAUUAU CUGAUGA X GAP. ATJUCAUUA CUGAUGA X GAA ACUGUUAU CUGAUGA X GAA AGACUGUU CUGAUGA X GA. AAGACUGU CUGAUGA X GAP. AGGUAAGA CUGAUGA X GAP. AUUUAGGU CUGAUGA X GAP. AAUUUAGG CUGAUGA X GAA AUAALTUUA Ribozyne Sequence

S

S. nt Position 2188 2192 2199 2208 2209 2212 2213 2216 2218 2221 2224 2229 2230 2231 2232 2233 2234 2243 2251 20 2252 2253 2255 2256 2259 2261 2262 2263 2264 2271 2280 2284 2286 2287 2288 2289 Target Sequence

AA.AUTJAUUA

UAUUAGGUA

UAAUGAAUU

GUGACCAU)

UGAC CAUUU

CCATJUUGLU

CAUTJUGUUA

UUGUUAAUA

GUUAAUAUC

AAT)AUCAUA

AUCAUAAUC

AAUCAGAUU

AUCAGAUUU

UCAGAUUU

CAGAUUUU

AGAUUUUUU

GAUUUUUUA

AAAAAAAUA

AAAAUGAUJ

AAAUGAUUJ

AAUGAUUUA

UGAUUAUT

GAtUUAUUU

TJUAUUUGUA

AUUUEGUAUJ

UUUGUAUUU

TUGUAUULU

UGUAUUUTUA

UAGAGAAUA

CAACAGAUC

AGAUCAGUA

AUCAGUAUJ

UCAGUAUU)

CAGUAUUUU

AGUAUUTU

GGUAAUGA

AUGAAUTUG

GUGACCAU

UGIJUAAUA

GTJUAAUAU

AAUAUCAU

AUAUCAUA

UCAUAAUC

AUAAUCAG

AUCAGAUJ

AGAUUUU

UUUAAAAA

UUAAAAAA

UAAAAAA

AAAAAAA

AAAUGAUU

AUUUGUA

UUGUAUU

UGUAUUUU

GUAUTJUUA

UTTIUAGAG

UUAGAGAA

UAGAGAAU

AGAGAAUA

GAGAAUAC

CAACAGAU

AGUAUUUU

UUTJUUGAC

UTIGACUG

UUGACUGU

UGACUGUG

GACUGUGG

UCATJUAC C

CAAUTJCAU

AUGGUCAC

UAUUAACA

AUAUUAAC

AUGAUAUJ

UAUGAUAU

GAUIATGA

CUGAUUAU

AAUCUGAU

AAAAAUCU

UUULTUAAA

UUUUUUUA

AUUTLTUU

AAUCAUU

UACAAAUA

AUACAAAU

AAUACAAA

AAAAUACA

UAAAAUAC

CUCUAAAA

UUCUCUAA

AUUCUCUA

UAUUCUCU

GUAUUCUC

AUCUGUUG

AAAAUACU

GUCAAAAA

CAGUCAAA

ACAGUCAA

CACAGUCA

CCACAGUC

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAEIGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAlA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAlA

GAA

GAA

GAA

GAA

GAlA

GAA

GAA

GAA

GAA

GAA

AAUAAUUU

ACCUAAUA

AUUCAUUA

AUGGUCAC

AAUGGUCA

ACAAAUGG

AACAAAUG

AUTJAACAA

AUAUUAAC

AUGAUAUU

AUTJAUGAU

AUCUGAUJ

AAUCUGAU

AAAUCUGA

AAAAUCUG

AAAAAUCU

AAAAAAUC

AUJUTTUJ

AUCAUUUU

AAUCAUUU

AAAUCAUU

AUAAAUCA

AAUAAAUC

ACAAAUAA

AUACAAAU

AAUACAAA

AAAUACAA

AAAAUACA

AUTJCUCUA

AUCUGUUG

ACUGAUCU

AUACUGAU

AAUACUGA

AAAUACUG

AAAAUACU

AUUCACCA

Tarqe Seqence Ribozymne Sequence 2303 UGGUGAAUU UAAAAAAA UUUUUUUA CUGAUGA nt. Target Sequence Posi- Ribozyme Sequence 55 *55a5* tion 2304 2305 2316 2317 2318 2330 2332 2338 2340 2341 2347 2349 2351 2355 2359 2365 2377 2378 2379 20 2380 2381 2399 2400 2402 2403 2404 2411 2412 2416 2420 2427 2430 2433 2434 2445 2447

GGUGAAUTU

GUGAAUUUA

AAAAAAAUU

AAAAAAUUU

AAAAAUUUA

A-AAGAAAUA

AGAAAUAUC

AU C CCAGUA

CCCAGUAUJ

CCAGUAUUC

UUC CAUGUA C CAUGUAUC

AUGUAUCUC

AUCUCAGUC

CAGUCACUA

CUAAACAUA

AGAGAGAUU

GAGAGAUU

AGAGAUUUU

GAGAUU.UU

AGAUU=EA

AGAAGCAUU

GAAGCAUTUA

AGCAUUAUU

GCAUUAUUT

CAUUAU=U

UUGAAUGUU

UGAAUGUUA

UGUUAGCUA

AG CUAAAU C

UCCCAAGUA

CAAGUAAUA

GUAAUACU

UAAUACLTUA

GCAACCCUC

AACCCUCUA

UACACAAA

ACACAA-AG

CACAAAGA

UCCCAGUA

C CAGUAUU

UEJCCAUGU

CCAUGUAU

CAUGUAUC

UCUCAGUC

UCAGUCAC

AGUCACUA

ACUAAACA

AACAUACA

CACAGAGA

UUUAAAAA

UUAAAAAC

UAAAAACC

AAAAACCA

AAAACCAG

AUUUUGAA

UUUUGAAU

UUGAAUGU

UGAAUGUU

GAAUGUUA

AGCUAAAU

G CUAAAUC

AAUCCCAA

CCAAGUAA

AUACUUAA

CUUAAUGC

AAUGCAAC

AUGCAACC

UAGGAGCU

GGAGCUCA

UUUGUGUA

CUUGUGU

UCUUUGUG

UACUGGGA

AAUACUGG

ACAUGGAA

AUACAUGG

GAUACAUG

GACUGAGA

GUGACUGA

UAGUGACU

UGUUAGU

UGUAUGUU

UCUCUGUG

UUUUUAAA

GUUTJUUAA

GGUUUUUA

UGGUUUUU

CUGGUUUU

UTUCAAAAU

AUUCAAAA

ACAUUCAA

AACAUTJCA

UAACAUJC

AUUtUAGCU

GAUUUAGC

UUGGGA-U

TJUACUUGG

UUAAGUAU

GCALUAAG

GUUGCAUJ

GGUUGCAU

AGCUCCUA

UGAGCUCC

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA AAUUCACC GAA AAAUtJCAC GAA AUUUUU GAA AAUUUUTJ GAA AAAUUULU GAA AUUUCUJT GAA AUAUTJUCU GAA ACUGGGAU GAA AUACUGGG GAA AAUACUGG GAA ACAUGGAA GAA AUACAUGG GAA AGAUACAU GAA ACUGAGAU GAA AGUGACUG GAA AUGUUUAG GAA AUCUCUCU GAA AAUCUCUC GAA AAAUCUCU GAA AAAAUCUC GAA AAAAAUCU GAA AUGCUUCU GAA AAUGCUUC GAA AUAAUGCU GAA AAUAAUGC GAA AAAUAAUG GAA ACAUIJUCAA GAA AACAUUCA GAA AGCUAACA GAA AUUUAGCU GAA ACUUGGGA GAA AUUACUUG GAA AGUAUUAC GAA AAGUATJUA GAA AGGGUUGC GAA AGAGGGUU S S. S S S. nt.

Position 2454 2457 2458 2465 2468 2471 2473 2480 2482 2484 2485 2486 2488 2489 15 2491 2493 2498 2499 2500 2510 2511 2512 2515 2518 2523 2527 2534 2535 2537 2538 2542 2548 2551 2552 2553 2554 Target Sequence UAGGAGCUC AUUUGUGG GAGCUCAUU UGUGGCUA AGCUCAUJU GUGGCUAA UTJGUGGCUA AUAAUCUU UGGCUAAUA AUCUUGGA CUAAUAAUC UUGGAAAU AAUAAUCUU GGAAAUAU UUGGAAAUA UCUUUAUU GGAAAUAUC LTEUAUUAU AAAUAUCUU UALUAUAU AAUAUCUJT AUTJAUAUA AUAUCUUUA UUAUAUAG AUCUUUAUU AUAUAGCA UCUUUEAtIUA UAUAGCAU UUUALTUAUA UAGCALUU UAUUAUAUA GCAUUUAU UAUAGCAUU UAUGAGGA AUAGCAUUEJ AUGAGGAG UAGCAUJTA UGAGGAGA GAGGAGAUU UUGUUGUC AGGAGAUUU UGUUGUCA GGAGAUUUU GUUGUCAG GAUJUUJGUTJ GUCAGCUU UUUGUUGUC AG CUUGCU UGUCAGCUU GCUUGAAA AGCUTJGCUU GAAAGUUA UUGAAAGUU AUTJAUGUA UGAAAGUUA UUAUGUAU AAAGUUAUU AUGUAUGA AAGUUAUUA UGUAUGAA UAUUAUGUA UGAAUAGU GUAUGAAUA GUITUUAUU UGAAUAGUU UUAUUGAA GAAUAGUUU UAUTJGAAA AAUAGUUUU AUIJGAAAA AUAGUUUtUA UUGAAAAA C CACAAAU

UAGCCACA

tJUAGCCAC

AAGAUUAU

UCCAAGAU

AUUUCCAA

AUAUTUC C

AAUAAAGA

AUAAUAAA

AUAUAAUA

UAUAUAAU

CUAUAUAA

UGCUAUAU

AUG CUAUA

AAAUGCUA

AUAAAUGC

UCCUCAUA

CUCCUCAU

UCUCCUCA

GACAACAA

UGACAACA

CUGACAAC

AAGCUGAC

AGCAAGCU

UTJUCAAG C

UAACUUC

UACAUAAU

AUACAUAA

UCAUACAU

UUCAUACA

ACUAtJUCA

AAUAAAAC

UUCAAUAA

UUUCAAUA

UTJUCAAU

UUUUUCAA

CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X GAA AGCUCCUA GAA AUGAGCUC GAA AAUGAGCU GAA AGCCACAA GAA AUUAGCCA GAA AUUtAUUAG GAA AGAUTUAUU GAA AUTJTCCAA GAA AUAUUUCC GAA AGAUAUTU GAA AAGAUAUU GAA AAAGAUAU GAA AUAAAGAU GAA AAUAAAGA GAA AUAAUAAA GAA AUAUAAUA GAA AUG CUAUA GAA AAUGCUAU GAA AAAUGCUA GAA AUCUCCUC GAA AAUCUCCU GAA AAAUCUCC GAA ACAA-AAUC GAA ACAACAAA GAA AGCUGACA GAA AGCAAGCU GAA ACUUUCAA GAA AACUTJUCA GAA AUAACUTU GAA AAUAACUTJ GAA ACAUAAUA GAA AUIJCAUAC GAA ACUATTUCA GAA AACUAUUC GAA AAACUAUU GAA AAAACUAU Ribozvme Sequence S. 55 S S S

S

555555 a.

a. a.

a a. nt.

Position 2556 2565 2566 2568 2570 2571 2572 2573 2574 10 2576 2577 2581 2584 2585 2586 2589 2590 2591 2594 20 2617 2618 2625 2630 2631 2632 2633 2638 2640 2643 2652 2656 2661 2672 2678 2679 2703 Target Sequence AGUUUUAUU GAAAAAAU GAAAAAATJU AUAUUUUU AAAA-AAUTJA UAUUUUUA AAAAUUAUA UUTJUUU AAUTJAUAUTJ JAUTJCA ATJUAUAUUtJ UIJAUUCAG

UUAUAUUUTJ

UAUAUUTUU

AUAUUUUTUA

AUUUUUAUU

UUUUUAUUC

UAUUCAGUA

UCAGUAAtU

CAGUAAUUU

AGTJAAUIJUA

AALTUUAATU

AUUUAAUUU

UUUAAUUUU

AAUUUrJGUA

AAAUGUGUU

AAUGUGUUC

UCGCUGCUA

UAULTCAGU

AUUCAGUA

UUCAGUAA

CAGUAAUTJ

AGUAAUUTJ

AUUUAAUTJ

UAAUUUG

AAUtJUUGU

AUUUUGUA

UUGUAAAU

UGUAAAUG

GUAAAUGC

AAUGCCAA

CGCUGCUA

GCUGCUAU

UGGUUUUA

AUTJUUUUC CUGAUGA X GAA AUAAAACU ATAA-AUAU CUGAUGA X GAA AUUTUUUC UAAAAAUA CUGAUGA X GAA AAUUUIUUU AAUAAAAA CUGAUGA X GAA AUAAUUUU UGAAUAAA CUGAUGA X GAA AUAUAATUU CUGAAUAA CUGAUGA X GAA AAUAUAAU ACUGAAUA CUGAUGA X GAA AAAUAUAA UACUGAAU CUGAUGA X GAA AAAAUAUA UUACUGAA CUGAUGA X GAA AAAAAUAU AAUUACUG CUGAUGA X GAA AUAAAA-AU AAALUACU CUGAUGA X GAA AAUAAAAA AAUUAAAU CUGAUGA X GAA ACUGAAUA CAAAAUUA CUGAUGA X GAA AUEJACUGA ACAAAAUU CUGAUGA X GAA AAUUACUG UACAAAAU CUGAUGA X GAA AAAUUACU AUUUACAA CUGAUGA X GAA AUUAAAUU CAUUUACA CUGAUGA X GAA AAUUAAAU GCAUUEJAC CUGAUGA X GAA AAAUTJAAP.

UUGGCAUU CUGAUGA X GAA ACAPAAUU UAGCAGCG CUGAUGA X GAA ACACAUUU AUAGCAGC CUGAUGA X GAA AACACAUU UAAAACCA CUGAUGA X GAA AGCAGCGA UAGGCUAA CUGAUGA X GAA ACCAUAGC AUAGGCUA CUGAUGA X GAA AACCAUAG UAUAGGCU CUGAUGA X GAA AAACCAUA CUAUAGGC CUGAUGA X GAA AAAACCAU CAUGACUA CUGAUGA X GAA AGGCUAAA ACCAUGAC CUGAUGA X GAA AUAGGCUA AGCAGCAU CUGAUGA X GAA ACUAUAGG ACACUAGC CUGAUGA X GAA AGCAGCAU CCUGACAC CUGAUGA X GAA AGCUAGCA UGCCCCCU CUGAUGA X GAA ACACUAGC CUAAGCUC CUGAUGA X GAA AUUGCCCC UUCCAUCU CUGAUGA X GAA AGCUCUAU UIJUCCAUC CUGAUGA X GAA AAGCUCUA CUAACACC CUGAUGA X GAA AGUCUCTU Ribozvme Sequence GCUAUGGUU UTJAGCCUA CUAUGGUUU UAGCCUAU UAUGGUUJU AGCCUAUA AUGGUUTJUA GCCUAUAG =UUAGCCUA UAGUCAUG UAGCCUAUA GUCAUGCU CCUAUAGUC AUGCUGCU AUGCUGCUA G CUAGUGU UGCUAGCUA GUGUCAGG GCUAGUGUC AGGGGGCA GGGGCAAUA GAG CUUAG AUAGAGCUU AGAUGGAA UAGAGCUUA GAUGGAAA AAGAGACUC GGUGUUAG nt. Target Sequence RbomeSune Ribozyme Sequence 4 .4 4 4.4.

4* 4* 44 4 4# Position 2709 2710 2714 2722 2729 2732 2734 2735 2742 2743 2744 2745 2746 2747 2749 2750 2751 2752 2753 2754 2756 2758 2760 2764 2768 2769 2770 2771 2774 2775 2776 CUCGGUGUU AGAUAACG UCGGUGUUA GAUAACGG UGUTJAGAUA ACGGACUA AACGGACUA UGCACUAG UAUGCACUA GUAUUCCA GCACUAGUA UUCCAGAC ACUAGUAUU CCAGACUJ CUAGUAtJUC CAGACUUU UCCAGACUU UUUUAUUU C CAGACUUJ UTJTUAUUUJ CAGACUUUU UUAUUUUTJ AGACUUUTJU UAUUUUUTJ GACUUUUUTJ AUTJUUUUA ACUJUTJUUA UUUUUJAU UIJUUUTUAUU UUUAUAU tJUUUUAUTJTU UUUAUAUA UUUUAUUIJU UUAUAUAU UUALUUUU UAUAUAUA UUAUTUUUUU AUAUAUAU UAUULUUJUA UAUAUAUG UUUUUUAUA UAUAUGUA UUTUUAUAUA UAUGUACC TJUAUAUAUA UGUACCUU AUAUAUGUA CCUTJUUCC AUGUACCUU UUCCUUUJ UGUACCUUU UCCUTJUUG GUACCUUUU CCUUUUGU UACCUUUUC CUUUUGUC CUUUUCCUU UUGUCAAU UT=tTCCUUU UGUCAAUU UUUCCUUTJU GUCAAUTJUG CGtJUAUCU

CCGUTJAUC

UAGUCCGU

CUAGUGCA

UGGAAUAC

GUCUGGAA

AAGUCUGG

AAAGUCUG

AAAUAA-AA

AAAAUAAA

AAAAAUAA

AAAAAAUA

UAAAAAAU

AUAAAAAA

AUAUAAAA

UAUAUAAA

AUAUAUAA

UAUAUAUA

AUAUAUAU

CAUAUAUA

UACAUAUA

GGUACAUA

AAGGUACA

GGAAAAGG

AAAAGGAA

CAAAAGGA

ACAAAAGG

GACAAAAG

AUUGACAA

AAUUGACA

CAAUTJGAC

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAU-C _A

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA ACACCGAG GAA AACACCGA GAA AUCUAACA X GAA AGUCCGTUU GAA AGUGCAUA GAA ACUAGUOC X GAA AUACUAGU GAA AAUACUAG X GAA AGUCUGGA X GAA AAGUCUGG X GAA AAAGUCUG GAA AAAAGUCU GAA AAAAAGUC GAA AAAAAAGU GAA AUAAAAAA GAA AAUAAAAA 4*

S

4 CUGAUGA X GAA AAAUAAAA CUGAUGA X GAA AAAAUAAA CUGAUGA X GAA AAAAAUAA CUGAUGA X GAA AAAAAAUA CUGAUGA X GAA AUAAAAAA CUGAUGA X GAA AUAUAAAA CUGAUGA X GAA AUAUAUAA CUGAUGA X GAA ACAUAUAU CUGAUGA X GAA AGGUACAU CUGAUGA X GAA AAGGUACA CUGAUGA X GAA AAAGGUAC CUGAUGA X GAA AAAAGGUA CUGAUGA X GAA AGGAAAAG CUGAUGA X GAA AAGGAAAA CUGAUGA X GAA AAAGGAAA Where "IXI represents stem II region of a HH ribozyme (Hertel et al., 1992 Nucleic Acids Res. 20 3252). The length of stem II may be 2. 2 base-pairs.

q 0

S.

0* 0 0 00 9 0000 00 0 00 *0 S 0 0 0000 00 00 0 *0 C 00 00 0 0*05 0000 9000 *0 00 0 0 0 0 &00000 0 0 Table XVI: Mouse c-myb Hairlpin ribozyme and target sequences Posi- RZ Substrate tion 24 GCGAGGCG AGAA GGGGCU AGCCCCG GCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA CGCCUCGC 28 CAUGGCGA AGAA GGCCGG CCGGCCC GCC ACCAGAGAAACACACGUUGUGGUACATJUACCUGGUA UCGCCAUG 122 A UUU GGGC AGAA GCCCAU AUGGGCU GCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA G CCCAAAU 125 CAGAUUUG AGAA GCAGCC GGCUGCU GCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA CAAAUCUG 216 UTJCCAGUC AGAA GUUCCG CGGAACA GAC ACCAGAGAAACACACGUUGUGGUACAUJACCUGGUA GACUGGAA 245 UCCGGUUG AGAA GAUAAU AUUAUCU GCC ACCAGAGAAACACACGJUGUGGUACAtJUACCUGGUA CAACCGGA 258 CACUGUAC AGAA GUCCGG CCGGACA GAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA GUACAGUG 529 CUCUGCCC AGAA GUUCCC GGGAACA GAU ACCAGAGAAACACACGUJGUGGUACAtJUACCUGGUA GGGCAGAG 551 GUCCGGGC AGAA GCUUUG CAAAGCU GCU ACCAGAGAAACACACGUUGUGGUACAUJACCUGGUA 'GCCCGGAC 554 UCCGUCCG AGAA GCAGCU AGCUGCU GCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA CGGACGGA 559 AUCAGUCC AGAA GGGCAG CUGCCCG GAC ACCAGAGAAACACACGUTJGUGGUACAUUACCUGGUA GGACUGAU 563 CAUUAUCA AGAA GUCCGG CCGGACG GAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA UGAUALAUG 656 CCACUGGC AGAA GOCUGO CCAGCCA GAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA GCCAGUGG 728 UUGGAGAG AGAA GAGAUG CAUCUCA GCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA CUCUCCA 746 UGACGGAG AGAA GGCCAC GUGGCCA GUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA

CUCCGUCA

822 UGCAAUGC AGAA GGAUAG CUAUCCU GUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA GCAUUGCA a a a. a 857 CCGCAGCC AGAA GAGGGA UCCCUCA GCC ACCAGAGAAACACACGUUGUGGUACAUJACCUGGUA GGCUGCGG 861 GCUGCCGC AGAA GGCUGA UCAGCCG GCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA GCGGCAGC 941 CUGUUGAC AGAA GGAGCA UGCUCCU GAU ACCAGAGAAACACACGUTJGUGGUACAUUACCUGGUA GUCAACAG 1040 GAGGUCUG AGAA GGUCCA UGGACCA GAC ACCAGAGAAACACACGtJUGUGGUACAUUACCUGGUA CAGACCUC 1045 CCCAUGAG AGAA GGUCUG CAGACCA GAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA CUCAUGGG 1068 AAACAGGA AGAA GGUGCA UGCACCU GUI ACCAGAGAAACACACGJUGUGGUACATJUACCUGGUA UCCUGUUU 1075 UUCUCCCA AGAA GGAA-AC GTUJCCU GUI ACCAGAGAAACACACGUJGUGGUACAUJACCUGGUA UGGGAGAA 1106 GAUCUGCA AGAA GAGAUG CAUCUCU CC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA UGCAGAUC 1113 GAGCCGGG AGAA GCAGGC GCCUGCA GATI ACCAGAGAAACACACGUIGTGGUACAUUACCUGGUA CCCGGCUC 1120 AGGUAGGG AGAA GGGAUC GAUCCCG GCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA CCCUACCU 1226 AAUCUAUA AGAA GGAGUG CACUCCA GUll ACCAGAGAAACACACGUJGUGGUACAUUACCUGGUA UAUAGAU 1340 UUUUCACA AGAA GGUCUC GAGACCA GAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA UGUGAAAA 1449 AUUUCUUG AGAA GCAAGG CCUTJGCA GCU ACCAGAGAAACACACGUJGUGGUACATJUACCUGGUA CAAGAAAU 1468 CUUCAGGG AGAA GUAUUU AAAUACG GUC ACCAGAGAAACACACGUJGUGGUACAUUACCUGGUA CCCUGAAG 1490 GGGAGGGG AGAA GAGGUA .UACCUCA GAC ACCAGAGAAACACACGUJGUGGUACAUUACCUGGUA CCCCUCCC 1542 CCAGAUUC AGAA GAUUCC GGAAUCG GAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA GAAUCUGG 1648 GUGGUTUUG AGAA GAAGAA UIJCUUCU GCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA CAAACCAC 1672 GGUGCUCA AGAA GUJTCUC GAGAACA GCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA UGAGCACC a a a a. a a. a a a. a a 1688 OCUGOGAG AGAA GUUGGG CCCAACU GtU ACCAGAGAAACACACGUJGUGGUACAUUACCUGGUA CUCGCAGG 1713 =UUGGGGC AGAA GCCACA UGUGGCA GAU ACCAGAGAAACACACGUJGUGGUACAUUACCUGGUA GCCCCAAA 1740 GUCAUUAA AGAA GAGCUJ AAGCUCU GUJ ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA UTJAAUGAC 1880 AGGCCGUC AGAA GGUCCU AGGACCA GAU ACCAGAGAAACACACGTUGUGGUACAUUACCUGGUA GACGGCCU 1887 GGACCGGA AGAA GUCAUC GAUGACG GCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA UCCGGUCC 1894 CCGAGCCG AGAA GGAGGC GCCUCCG GUC ACCAGAGAAACACACGUTJGUGGUACAUUACCUGGUA

CGGCUCGG

1899 UAUUUCCG AGAA GGACCG CGGUCCG GCU ACCAGAGAAACACACGUGUGGUACAUUACCUGGUA CGGAAAUA 1926 AGAGUIJCG AGAA GAGAAC GUUCUCA GCU ACCAGAGAAACACACGUJGUGGUACAUUACCUGGUA CGAACIJCU 2048 ACAACAAA AGAA GGCUCU AGAGCCU GAU ACCAGAGAAACACACGUUGUGGUACAUUAC CUGGUA UUUGUUGU 2068 CUGCUCUC AGAA GUUGUA UACAACA GUI ACCAGAGAAACACACGUUGUGGUACAUUAC CUGGUA GAGAGCAG 2170 UUAGGUAA AGAA GtJUAUJ AAUAACA GUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA UTJACCUAA 2225 tAAAAA AGAA GAUUAU AUAAUCA GAU ACCAGAGAAACACACGIJUGUGGUACAUUACCUGGUA

UUUTJUAAA

2276 AAAUACUG AGAA GTJUGUA UACAACA GAU ACCAGAGAA-ACACACGUJGUGGUACAUUACCUGGUA CAGUAUUU 2519 LTUCAAGCA AGAA GACAAC GUTIGUCA GCU ACCAGAGAAACACACGUUGUGGUACAUUAC CUGGUA UG CUUGAA 2717 AGUGCAUA AGAA GUIJAUC GAUAACG GAC ACCAGAGAAACACACGTJUGUGGUACAUJACCUGGUA UAUGCACU 2737 AUAAAAAA AGAA GGAAUA UAUUCCA GAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA UULUUAU Table XVII: Rat c-mnyb (Recgion A) .,Hammerhead Ribozyme and Target Secruences (282 bip; nt. 428 start; human c-myvb numbering system) nt.

Position 467 470 477 498 509 515 518 526 531 544 548 549 551 562 563 575 588 609 25 610 615 623 624 634 659 662 663 664 666 Target Sequence CCUGAGCUC AUCAAAGG

GAGCUCAUC

UCAAAGGUC

AAGAAGAUC

AGAGUGAUA

AUAGAGCUU

GAGCUUGUC

CCAGAAAUA

AAUACGGUC

GCGCUGGUC

UGGUCUGUJT

GGUCUGUUA

UCUGUUAU

CAAGCACUJ

AAAGGUCC

CCUGGACC

AAAGAGUG

GAGCUUGU

GUCCAGAA

CAGAAAUA

CGCUCCGA

CGAAGCGC

UGUUAUJG

AUUGCCAA

UUG CCAAG

GCCAAGCA

AAAAGGGA

S

AAGCACUJA AAAGGGAG GGGAGAAUJ GGAAAACA AACAAUGUC GGGAGAGG ACAACCAUJ UGAAUCCA CAACCAUUJ GAAUCCAG AUIJTGAAUC CAGAAGUU C CAGAAGUJ AAGAAAAC CAGAAGUUA AGAAAACC GAAA-ACCUC AUGGACAG GACAGAAUC AUL=UAUCA AGAAUCAUU UAUCAGGC GAAUCAUUJ AUCAGGCA AAUCAUUUA UCAGGCAC UCAUJUAtJC AGGCACAC

GGACCUU

GGUCCAGG

CACUCUUU

ACAAGCUC

UUCUGGAC

UAUTJUCUG

UCGGACCG

GCGCUUCG

CAAUAACA

UTUGGCAAU

CUUTGGCAA

UGCUTJGGC

UCccUUUU cUccCUUU

UGUUUTUCC

ccUcUCCC

UGGAUJCA

CUGGAUUC

AACUUCUG

GUUUUCLU

GGU=JJCU

CUGUCCAU

UGAUAAAU

GCCUGAUA

UGCCUGAU

GUGCCUGA

GUGUGCCU

Ribozyme Sequence CCUTJUGAU CUGAUGA X GAA AGCUCAGG CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X GAA AUGAGCUC GAA ACCUUUGA GAA AUCUUCU GAA AUCACUCU GAA AGCUCUAU GAA ACAAGCUC GA-A AUUUCUGG GAA ACCGUAUJ GAA ACCAGCGC GAA ACAGACCA GAA AACAGACC GAA AUAACAGA GAA AGUGCUTUG GAA AAGUGCUJ GAA AUUCUCCC GAA ACAUUGUU GAA AUGGUUGU GAA AAUGGUUG GAA AUUCAAAU GAA ACIJUCUGG GAA AACUUCUG GAA AGGUUUC GAA AUTJCUGUc GAA AUGAUUCU GAA AAUGAUUC GAA AAAUGAUUJ GAA AUAAAUGA Where "IX" represents stem II region of a HH ribozyme (Hertel et, al. 1992 Nucleic Acids Res. 20 3252) The length of stem II may be 2 base-pairs.

Table XVIII: Rat c-mvb (Recrion B) Hammerhead Ribozyme and Target Sec uences (262 b-p; nt.421 start; human c-mvb numbering system) 0* a 4* a a. a a nt.

Posi tion 1429 1430 1434 1440 1443 1444 1445 15 1450 1458 1460 1463 1467 1485 1509 1522 1526 1528 25 1529 1530 1536 1542 1544 1552 1556 1559 1567 1569 1578 1588 1589 1608 1616 Target Sequence CUCGGGCJU AGAUACGC UCGGGCUUA GAUACGCC GCtTUAGAUA CGCCUACU AUACGCCUA CtJUUACCC CGCCUACUU UACCCUCC GCCUACUU= ACCCUCCA CCUACUUUA CCCUCCAC =TIACCCUC CACGCCUC CCACGCCUC IUCAUUGGU ACGCCUCUC AUTJGGUCA CCUCUCAUU GGUCACAA UCAUUGGUC ACAA.ACUG CACCGUGUC ACCGAGAC UGAAAACUN AAAAGGAA GGAAAACTJC NAUCUTJUA AACUCNAUC UUUAGAAC CTJCNAUCUU UAGAACUC UCNAUCUUU AGAACUCC CNAUCUUUA GAACUCCA UIJAGAACUC CAGCUAUC CUCCAGCUA UCAAAAGG CCAGCUAUC AAAAGGUQ CAAAAGGUN AAUCCUCG AGGUNAAUC CUCGAAAG UNAAUCCUC GAAAGCUC CGAAAGCUC UCCCAGAA AAAGCUCUC CCAGAACU CCAGAACUC CCACACCA CACACCAUU CAAACAUG ACACCAUUC AAACAUGC UGGCAGCUC AAGAAAUU CAAGAAAUUi AAAUACGG Ribozyme G CGUAUCU

GGCGUAUC

AGUAGGCG

GGGUAAAG

GGAGGGUA

UGGAGGGU

GUGGAGGG

GAGGCGUG

ACCAAUGA

UGACCAAU

UtJGUGACC

CAGUUUGU

GUCUCGGU

LUtC CU-U-Uu

UAAAGAUN

CtIUCUAAA

GAGTJUCTJA

GGAGUUCU

UGGAGUUC

GAUAGCUG

CCUUUGA

NACCUUUU

CGAGGAUU

CUUUCGAG

GAGCUUUC

tJUCUGGGA

AGUUCUGG

UGGUGUGG

CAUGUUUG

GCAUGUEU

AAUUTJCUU

CCGUAUUU

CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X GAA AGCCCGAG GAA AAGCCCGA GAA AUCUAAkGC GAA AGGCGUAU GAA AGUAGGCG GAA AAGUAGGC GAA AAAGUAGG GAA AGGGUAAA GAA AGGCGUGG GAA AGAGGCGU GAA AUGAGAGG GAA ACCAAUGA GAA ACACGGUG GAA AGUUUCA GAA AGUUUUCC GAA AUTNGAGUU GAA AGAUNGAG GAA AAGAUNGA GAA AAAGAUNG GAA AGtJUCUAA GAA AGCUGGAG GAA AU-AG CUGG GAA ACCUTJUG GAA AUIJNACCU GAA AGGAUTINA GAA AGCUUUCG GAA AGAGCUUU GALA AGUUCUGG GAA AUGGUGUG GAA AAUGGUGU GAA AGCUGCCA GAA AUUJUG Seauence 100 nt.

Posi tion 1429 1617 1621 1626 1640 1644 16S4 1656 1661 1664 10 1673 Target Sequence CUCGGGCUJ AGAUACGC AAGAAAUUA AAUACGGU AAUUAAAUA CGGUCCCC AAUACGGUC CCCUGAAG AAGAUGCUA CCTJNAGAC UGCUACCJN AGACCCCC GACCCCCUN UNAUGUAC CCCCCUNUN AUGUAGUN UNTJNAUGUA GUNNNANA NAUGUAGUN NNANACCU NNANACCUN CANGAUGU Ribozxrme Sequence

GCGUAUCU

ACCGtJAUU

GGGGACCG

CUUCAGGG

GUCUNAGG

GGGGGUCU

CUACAUNA

NACUACAU

UNUNThNAC

AGGUNUNN

ACAUCNUG

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

X GAA AGCCCGAG X GAA AAUUCUU X GAA AUUUAAUU X GAA ACCGUAUU X GAA AGCAUCUU X GAA AGGUAGCA X GAA AGGGGGUC X GAA AIJAGGGGG X GAA ACAUNANA X GAA ACUACAUN X GAA AGGUNUNN a HH ribozyme 20 3252).- The a. S.

S

Where represents stem II region of (Hertel et al. 1992 Nucleic Acids Res.

length of stem II may be a 2 base-pairs.

Table XIX: Rat c-mvb (Region A) HairiDin Ribozvme and

S

Target Seauences (282 biD; nt. 428 start; human numbering system) Posi- RZ Substrate t ion 528 GCGCUUCG AGAA GUAUUU AAAUACG GUC ACCAGAGAAACACACGUUGUGGUACAJUAcCUGGUA

CGAAGCGC

690 UUCUGCCC AGAA GUUUCC GGAAACA GAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA GGGCAGAA 101 Table XX: Rat c-myb (Region B) Hairpin Ribogyme and Target Secruences (262 bp; nt 1421 start; human numbering system) Posi- RZ Substrate tion 1495 UUUTJCACA AGAA GGUCUC GAGACCA GAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA UGUGAAAA 1604 AUTJCUUG AGAA GCCAGG CCUGGCA GCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA CAAGAAAU 1623 CUUCAGGG AGAA GUAUUJ AAAUACG GUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA CCCUGAAG Table XXI: Porcine c-mvb (Region A) Hammerhead Ribozyne and Target Sequence (266 bp; nt. 458 start; human c-rnyb numbering system) nt.

Position 467 470 477 480 498 509 515 518 526 531 540 544 548 549 551 562 563 575 588 603 610 Target Secruence

CCUAUCUC

NAUCUCAUC

UCAAGGGUC

AGGGUCCUU

AAGAAGAUC

AGAGUGAUA

AUAGAGCUU

GAGCUGUA

ACAGAAAUA

AAUACGGUC

CGAAACGUU

ACGUUGGUC

UGGUCUGUU

GGUCUGLTUA

UCUGLTUAUU

cAAGCAcu

AAGCACUUA

GGGAGAAUU

AACAAUGUA

GGUGGCAUA

UAACCACUU

AUCAAGGG

AAGGGUCC

CUGGACC

GGACCAAA

AGAGAGUG

GAGCUUGU

GUACAGAA

CAGAAAUA

CGGUCCGA

CGAAACGU

GGUCUGUTJ

UGUUAUTUG

AUUGCCAA

UUGCCAAG

GCCAAGCA

AAAGGGGA

AAGGGGAG

GGAAAACA

GGGAGAGG

ACCACUEJO

GAAUCCAG

CCcuAUo GGAcCu

GGUCCAAG

UUGGUCC

CACUCUCU

ACAAGCUC

UUCUGtJAC

UAUUUCUG

UCGGACCG

ACGUUUCG

AACAGACC

CAAUAACA

UUGGCAAU

CUUGGCAA

UGCUUGGC

UCCCCuu cuccccuu

UGUUUUCC

ccucuccc CAAGtJGGU CUGGAtJUC

CUGAUGA

CUGAUGA

CtJGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CTJGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CTJGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

CUGAUGA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

AGAUINAGG

AUGAGAUN

ACCCUIGA

AGGACCCU

AUCUJCUJ

AUCACUCU

AGCUCUAU

ACAAGCUC

AUUUCUGU

ACCGUAUU

ACGUUUCG

ACCAACGU

ACAGACCA

AACAGACC

AUAACAGA

AGUGCUUG

AAGUGCU

AUUCUCCC

ACAUTUGU

AUG CCACC

AGUGGLUA

Ribozvrne Sequence nt.

Position 615 623 624 634 659 660 662 663 664 704 713 Target Sequence ACUIJGAAUC CAGAAGUU CCAGAAGUIJ AAGAAAAC CAGAAGUUA AGAAAACC GAAAACCUC CUGGACAG GACAGAAUU AUUUACCA ACAGAAUUA UTJUACCAG AGAAUUAUU UACCAGGC GAAUUAtJUU ACCAGGCA AAUUAUUUA CCAGGCAC GCGGAAAUC GCAAAGCU GCAAAGCUA CUGCCUGG Ribozyme Searuence AAC=UCUG CUGAUGA X GAA AUUCAAGU GUUI=UCUU CUGAUGA X GAA ACUUCUGC GGtJL=tJCU CUGAUGA X GAA AAC=UCUG CUGUCCAG CUGAUGA X GAA AGGUUUUC UGGUAAAU CUGAUGA X GAA AUTJCUGUC CUGGUAAA CUGAUGA X GAA AAUTJCUGU GCCUGGUA CUGAUGA X GAA AUAAUTJCU UGCCUGGU CUGAUGA X GAA AAUAAUTJC GUGCCUGG CUGAUGA X GAA AAAUAAUTJ AGCU=UGC CUGAUGA X GAA AUT=UCCGC CCAGGCAG CUGAUGA X GAA AGCUTJUGC II region of a HH ribozyme *0 a. Where represents stem (Hertel et al. 1992 Nucleic Acids Res. 20 3252).

lengr,:h of stem TI may be 2 base-pairs.

The Table XXII: Porcine c-myb (Region B) Hammerhead Ribozyme and Target Sequence (308 bp; nt. 1386 start; human c-mvb numbering system) a.

a a a nt.* Position 1394 1396 1397 1404 1405 1410 1423 1424 1429 1440 1441 1443 1444 1445 Target Sequence GAUUCUJTC UUAAACAC UUCIJ=UCUU AAACACUU UCTJUUCUUA AACACUUC UAAACACITU CCAAUAAC AAACACUUC CAAUAACC CtUCCAAUA ACCAUGAA UGAAAACUU AGACUUGG GAAAACUUA GACUUGGA CUU.AGACUU GGAAAUG C AAAUGCCUU CU=UAACG AAUGCCUTJC UUUAACGU UGCCIJUCUUT UAACGUCC GCCUUCUUTJ AACGUCCA CCUUCUUt3A ACGUCCAC Ribozyme Sequence GUGUUUAA CUGAUGA AAGUGUUU CUGAUGA GAAGUGUJ CUGAUGA GUtJAUEGG CUGAUGA GGUUATJUG CUGAUGA UUCAUGGU CUGAUGA CCAAGUCU CUGAUGA UCCAAGUC CUGAUGA GCAUTUCC CUGAUGA CGUUAAAG CUGAUGA ACGUUAAA CUGAUGA GGACGUUA CUGAUGA UGGACGIJU CUGAUGA GUGGACGU CUGAUGA GAA AAAGAAUC GAA AGAAAGAA GAA AAGAAAGA GAA AGUGUUUA GAA AAGUGUU GAA AUUGGAAG GAA AGUJTCA GAA AAGUUUUC GAA AGUCUAAG GAA AGGCAJUTJ GAA AAGGCAUJ GAA AGAAGGCA GAA AAGAAGGC GAA AAAGAAGG 103 1450 UUUAACGUC CACGCCUC 1458 CCACGCCUC UCAGUGGU GAGGCGUG CUGAUGA X GAA ACGUJUAAA a.

a.

a. a a a a a 1460 1467 1474 1481 1482 1492 1493 1494 1497 1530 1534 1536 15 1537 1538 1539 1545 1551 1553 1561 1565 1576 1578 25 1587 1590 1597 1598 1610 1617 1625 1626 1630 1635 1649 1653 1663 1665

ACGCCUCUC

UCAGUGGUC

UCACAAAUI

UUGACUGUT

UGACUGUU;P

AACACCAUT

A CA CCAUUI: CA CCAUTUC

CAUTJUCAUA

AGGAAAAUA

A-AAUACAUA

AUACAUAUTJ

UACAUAUUU

ACAUAUUUU

CAUAUUUUU

LUUGAACtJC

CUCCGGCUA

CCGGCUAUC

CAAAAGGJC

AGGUCAAUC

GGAAAGCUC

AAAGCUCtJC

CAAGAACUC

GAACUCCUA

UACACCGUJ

ACACCGUUC

CAUGCACUC

UCGCAGCUC

AGUGGUCA

ACAAAUJG

T GACUGUUA J ACAACACC

LCAACACCA

fUCAUAGAG rCAUAGAGA

AUAGAGAC

GAGACCAG

CAUAUUUU

UUUUUGAA

LUUJGAACU

UUGAACUC

TJGAACUCC

GAACUCCG

CGGCUAUC

UCAAAAGG

AAAAGGUC

AAUCCUGG

CUGGAAAG

UCCAAGAA

CAAGAACU

CUACACCG

CACCGUJC

CAAACAUG

AAACAUG C

GCAGCUCA

AAGAAAUU

ACCACUGA

UGACCACU

CAAUUTJGU

UAACAGUC

GGUGUUGU

UGGUGUJG

CUCUAUGA

UCUCUAUG

GUCUCUAU

CUGGUCUC

AAAAUAUG

UUCAAAAA

AGUUCAAA

GAGUUCAA

GGAGUTUCA

CGGAGUIJC

GAUAGCCG

CCUUUTUGA

GACCUUUU

CCAGGAUU

CUUtJCCAG

UUCUUGGA

AGUUJCUUG

CGGUGUAG

GAACGGUG

CAUGULJUG

GCAUGUU

UGAGCUGCC

AAUUUCUJ C CCAUAUUJ C ACCAUAUU C GGGGACCA C CUtJCAGGG C GUCUGAGG C UGGUGUCU C CUAAAUGA C UACTJAAAU C CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAUGA X CUGAtJGA X CUGAUGA X CUGAUGA X CUGAUGA X UGAUGA XC 'UGAUGA X C "UGAUGA X C UGAUGA X C UGAUGA X C UGAUGA X C :UGAUGA X G ~UGAUGA X G ~UGAUGA X C ~UGAUGA X G ~UGAUGA X G UGAUGA XG

GA

GA

GA.

GK.

Gk.

GkJ GA2 GAi

GA;

GA7 GAl

GAJT

GMA

GAA

GAA

GAA

GAA

GAA

GAA

GAA

.,AA

GAA

3AA 3

AA

3AA

,AA

;AA

~AA

~AA

~AA

~AA

7

AA

~AA

~AA

~AA

AA

AA

AAGGCGUGG

AAGAGGCGU

AACCACUGA

AAUtJUGUGA

~ACAGUCAA

SA-ACAGUCA

SAUGGUGUUr

SAAUGGUGU

AAAUGGUG

SAUGAAAUG

AUUUUCCU

AUGUAJUUTJ

AUAUGUAU

AAUAUGUA

AAATJAUGU

AAAAUAUG

AGUUCAAA

AGCCGGAG

AUAGCCGG

ACCUTJUUG

AtIUGACCU

AGCUUUCC

AGAGCUU

AGTJUCUUG

AGGAGUJC

ACGGUGUA

AACGGUGU

AGUGCAUG

AG CUGCGA

AUULUCUUG

AAUUCU

AUIJUAAUU

AC CAUATU AG CAUCUU

AGGUAGCA

AUGGUGUC

AGAUGGUG

a. as a a CAAGAAAUU AAAUAUGG AAGAAALUA AAUAUGGU AAUtJAAAUA

UGGUCCCC

AAUAUGGUC CCCUGAAG AAGAUGCUA CCUCAGAC UGCUACCUC AGACACCA GACACCAUC UCATJUUAG CACCAUCUC AUTJUAGUA 1668 CAUCUCALTU UAGUAGAA 1668 CAUCCAUUUAGUGAA UCUACUA CUGAUGA X GAA AUGAGAUG 104 1669 1670 1673 AUCUCAUUU AGUAGAAG CUUCUACU CUGAUGA X GAA AAUGAGAU UCUCAUUUA GUAGAAGA UCUUCUAC CUGAUGA X GAA AAAUGAGA CAUUUAGUA GAAGACCU AGGUCUUC CUGAUGA X GAA ACtJAAAUG Where "IX" represents stem II region of a HH ribozyme (Hertel et al., 1992 Nucleic Acids Res. 20 3252). The length of stem II may be z- 2 base-pairs.

Table XXIII: Porcin& c-mvb (region A) Hairoin Rihfl7\rm~ Table XXIII: Porcine c-mvb and Target Sec ence (266bp nt. 458 start; Human numbering 99 99 9 9.99 9*99 9 99 99 9 9 9 system) SPosi- RZ jSubstrate 528 ACGUUUCG AGAA GUAIUU

ACCAGAGAAACACACGUUGUGGUACAUJTACCUGGUA

AAAUACG GUC

CGAAACGU

UUCCGCCC AGAA GUUCCC

ACCAGAGAAACACACGUUGUGGUACAJ'TACCUGGUA

GGGAACA GAU Table XXIV: Porcine c-myb (region B) Hairpin Ribozyme and Target Seauence (308 bp; nt. 1386 start; Human numbering 20 system) Posi- Hairpin Ribozyme Substrate tion 1504 UtUUUCACA AGAA GGUCUC GAGACCA GAC ______AccAGAGAAACACAcGUUGUGGUAcAUJACcUGGUA

UGUGAAAA

1594 CAUGULUG AGAA GUGUAG cuAcAcc GUTJ ______ACCAGAGAAACAcACGUUGUGGUACAUJACCUGGUA cAAACAUG 1613 AUIJUCUTJG AGAA GCGAGU AcUcGcA GCU ______AccAGAGAAAcACAcGUUGUGGUAcAUTJAccUGGUAI

CAAGAAAU

SEQUENCE LISTING GENERAL INFORMATION:

APPLICANT:

(ii) TITLE OF INVENTION: (iii) NUMBER OF SEQUENCES: (iv) CORRESPONDENCE ADDRESS: Ribozyme Pharmaceuticals Inc.

METHODS AND COMPOSITIONS FOR TREATMENT OF RESTENOSIS AND CANCER USING RIBOZYMES 2733 p

(A)

(B)

(C)

(D)

(E)

(F)

ADDRESSEE:

STREET:

CITY:

STATE:

COUNTRY:

ZIP:

Lyon Lyon 633 West Fifth Street Suite 4700 Los Angeles California

U.S.A.

90071-2066 COMPUTER READABLE FORM: MEDIUM TYPE:

COMPUTER:

OPERATING SYSTEM:

SOFTWARE:

3.5" Diskette, 1.44 Mb storage IBM Compatible IBM P.C. DOS Word Perfect 5.1 (vi) CURRENT APPLICATION DATA: APPLICATION NUMBER: FILING DATE: PCT/US95/06368 18 May 1995 (vii) PRIOR APPLICATION DATA: APPLICATION NUMBER: FILING DATE: US 08/245,466 18 May 1994 (viii) ATTORNEY/AGENT INFORMATION:

NAME:

REGISTRATION NUMBER: REFERENCE/DOCKET NUMBER: (ix) TELECOMMUNICATION INFORMATION: Warburg, Richard J.

32,327 209/035-PCT

TELEPHONE:

TELEFAX:

TELEX:

(213) 489-1600 (213) 955-0440 67-3510 io06 INFORMATION FOR SEQ ID NO:1: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1: CCUGAGCUCA UCAAAGG 17 INFORMATION FOR SEQ ID NO:2: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2: CCUUUGAUCU GAUGAGGCCG AAAGGCCGAA AGCUCAGG 38 INFORMATION FOR SEQ ID NO:3: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S* TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3: GAGCUCAUCA AAGGUCC 17 INFORMATION FOR SEQ ID NO:4: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 9. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4: GGACCUUUCU GAUGAGGCCG AAAGGCCGAA AUGAGCUC 38 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID UCAAAGGUCC CUGGACC 17 INFORMATION FOR SEQ ID NO:6: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6: i07 S GGUCCAGGCU GAUGAGGCCG AAAGGCCGAA ACCUUUGA 38 INFORMATION FOR SEQ ID NO:7: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7: AAGAAGAUCA AAGAGUG 17 INFORMATION FOR SEQ ID NO:8: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8: S* CACUCUUUCU GAUGAGGCCG AAAGGCCGAA AUCUUCUU 38 INFORMATION FOR SEQ ID NO:9: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9: AGAGUGAUAG AGCUUGU 17 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 4 (xi) SEQUENCE DESCRIPTION: SEQ ID ACAAGCUCCU GAUGAGGCCG AAAGGCCGAA AUCACUCU 38 INFORMATION FOR SEQ ID NO:11: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:ll: AUAGAGCUUG UCCAGAA 17 INFORMATION FOR SEQ ID NO:12: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 108 O (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12: UUCUGGACCU GAUGAGGCCG AAAGGCCGAA AGCUCUAU 38 INFORMATION FOR SEQ ID NO:13: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13: GAGCUUGUCC AGAAAUA 17 INFORMATION FOR SEQ ID NO:14: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14: UAUUUCUGCU GAUGAGGCCG AAAGGCCGAA ACAAGCUC 38 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID CCAGAAAUAC GGUCCGA 17 INFORMATION FOR SEQ ID NO:16: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16: UCGGACCGCU GAUGAGGCCG AAAGGCCGAA AUUUCUGG 38 INFORMATION FOR SEQ ID NO:17: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17: AAUACGGUCC GAAGCGC 17 INFORMATION FOR SEQ ID NO:18: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18: GCGCUUCGCU GAUGAGGCCG AAAGGCCGAA ACCGUAUU 38 INFORMATION FOR SEQ ID NO:19: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19: GCGCUGGUCU GUUAUUG 17 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID CAAUAACACU GAUGAGGCCG AAAGGCCGAA ACCAGCGC 38 INFORMATION FOR SEQ ID NO:21: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21: UGGUCUGUUA UUGCCAA 17 INFORMATION FOR SEQ ID NO:22: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22: UUGGCAAUCU GAUGAGGCCG AAAGGCCGAA ACAGACCA 38 INFORMATION FOR SEQ ID NO:23: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23: GGUCUGUUAU UGCCAAG 17 INFORMATION FOR SEQ ID NO:24: i 1 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24: CUUGGCAACU GAUGAGGCCG AAAGGCCGAA AACAGACC 38 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID UCUGUUAUUG CCAAGCA 17 INFORMATION FOR SEQ ID NO:26: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26: UGCUUGGCCU GAUGAGGCCG AAAGGCCGAA AUAACAGA 38 INFORMATION FOR SEQ ID NO:27: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27: S: CAAGCACUUA AAAGGGA 17 INFORMATION FOR SEQ ID NO:28: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28: UCCCUUUUCU GAUGAGGCCG AAAGGCCGAA AGUGCUUG 38 INFORMATION FOR SEQ ID NO:29: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29: AAGCACUUAA AAGGGAG 17 I 1 1 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID CUCCCUUUCU GAUGAGGCCG AAAGGCCGAA AAGUGCUU 38 INFORMATION FOR SEQ ID NO:31: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:31: GGGAGAAUUG GAAAACA 17 INFORMATION FOR SEQ ID NO:32: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32: SUGUUUUCCCU GAUGAGGCCG AAAGGCCGAA AUUCUCCC 38 INFORMATION FOR SEQ ID NO:33: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33: AACAAUGUCG GGAGAGG 17 INFORMATION FOR SEQ ID NO:34: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:34: CCUCUCCCCU GAUGAGGCCG AAAGGCCGAA ACAUUGUU 38 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID ACAACCAUUU GAAUCCA 17 INFORMATION FOR SEQ ID NO:36: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36: UGGAUUCACU GAUGAGGCCG AAAGGCCGAA AUGGUUGU 38 INFORMATION FOR SEQ ID NO:37: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37: 00 CAACCAUUUG AAUCCAG 17 INFORMATION FOR SEQ ID NO:38:

*S*

SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38: CUGGAUUCCU GAUGAGGCCG AAAGGCCGAA AAUGGUUG 38 INFORMATION FOR SEQ ID NO:39: *000* SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 0:000: (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39: AUUUGAAUCC AGAAGUU 17 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID AACUUCUGCU GAUGAGGCCG AAAGGCCGAA AUUCAAAU 38 INFORMATION FOR SEQ ID NO:41: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear i (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41: CCAGAAGUUA AGAAAAC 17 INFORMATION FOR SEQ ID NO:42: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42: GUUUUCUUCU GAUGAGGCCG AAAGGCCGAA ACUUCUGG 38 INFORMATION FOR SEQ ID NO:43: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43: SCAGAAGUUAA GAAAACC 17 INFORMATION FOR SEQ ID NO:44: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44: 0. GGUUUUCUCU GAUGAGGCCG AAAGGCCGAA AACUUCUG 38 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID GAAAACCUCA UGGACAG 17 INFORMATION FOR SEQ ID NO:46: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46: CUGUCCAUCU GAUGAGGCCG AAAGGCCGAA AGGUUUUC 38 INFORMATION FOR SEQ ID NO:47: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid I 1 4- STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47: GACAGAAUCA UUUAUCA 17 INFORMATION FOR SEQ ID NO:48: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48: UGAUAAAUCU GAUGAGGCCG AAAGGCCGAA AUUCUGUC 38 INFORMATION FOR SEQ ID NO:49: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY:- linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49: S AGAAUCAUUU AUCAGGC 17 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID GCCUGAUACU GAUGAGGCCG AAAGGCCGAA AUGAUUCU 38 INFORMATION FOR SEQ ID NO:51: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51: GAAUCAUUUA UCAGGCA 17 INFORMATION FOR SEQ ID NO:52: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:52: UGCCUGAUCU GAUGAGGCCG AAAGGCCGAA AAUGAUUC 38 INFORMATION FOR SEQ ID NO:53: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs 1 TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:53: AAUCAUUUAU CAGGCAC 17 INFORMATION FOR SEQ ID NO:54: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:54: GUGCCUGACU GAUGAGGCCG AAAGGCCGAA AAAUGAUU 38 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID UCAUUUAUCA GGCACAC 17 INFORMATION FOR SEQ ID NO:56: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:56: GUGUGCCUCU GAUGAGGCCG AAAGGCCGAA AUAAAUGA 38 INFORMATION FOR SEQ ID NO:57: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:57: GCGCUUCGAG AAGUAUUUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:58: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:58: AAAUACGGUC CGAAGCGC 18 INFORMATION FOR SEQ ID NO:59: I Ie SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:59: UUCUGCCCAG AAGUUUCCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID GGAAACAGAU GGGCAGAA 18 INFORMATION FOR SEQ ID NO:61: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:61: UUUUCACAAG AAGGUCUCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:62: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:62: GAGACCAGAC UGUGAAAA 18 9 INFORMATION FOR SEQ ID NO:63: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS; single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:63: AUUUCUUGAG AAGCCAGGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:64: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:64: CCUGGCAGCU CAAGAAAU ,o S1 ~7 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID CUUCAGGGAG AAGUAUUUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:66: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:66: AAAUACGGUC CCCUGAAG 18 INFORMATION FOR SEQ ID NO:67: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:67: ACGUUUCGAG AAGUAUUUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:68: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:68: AAAUACGGUC CGAAACGU 18 INFORMATION FOR SEQ ID NO:69: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:69: UUCCGCCCAG AAGUUCCCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID S GGGAACAGAU GGGCGGAA 18 INFORMATION FOR SEQ ID NO:71: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:71: UUUUCACAAG AAGGUCUCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:72: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:72: S* GAGACCAGAC UGUGAAAA 18 INFORMATION FOR SEQ ID NO:73: S* SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:73: CAUGUUUGAG AAGUGUAGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:74: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:74: CUACACCGUU CAAACAUG 18 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID AUUUCUUGAG AAGCGAGUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:76: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear

I

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:76: ACUCGCAGCU CAAGAAAU INFORMATION FOR SEQ ID NO:77: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:77: GGAGAAUUGG AAAAC INFORMATION FOR SEQ ID NO:78: SEQUENCE CHARACTERISTICS: LENGTH: 37 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (ix) FEATURE: OTHER INFORMATION: The letter is A, U, or C.

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:78: GUUUUCCCUG AUGAGGCCGA AAGGCCGAAA UUCUCCH INFORMATION FOR SEQ ID NO:79: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:79: CGUCACUUGG GGAAA INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID GUCUGUUAUU GCCAA INFORMATION FOR SEQ ID NO:81: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:81: CUGUUAUUGC CAAGC 37 120 INFORMATION FOR SEQ ID NO:82: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:82: GGAGAAUUGG AAAAC INFORMATION FOR SEQ ID NO:83: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:83: S AAAACCUCCU GGACA INFORMATION FOR SEQ ID NO:84: SEQUENCE CHARACTERISTICS: S* LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:84: SUAAUGCUAUC AAGAA INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID CAAGCUUCCA GAAGA INFORMATION FOR SEQ ID NO:86: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:86: UUCCUAUUAC CACAU INFORMATION FOR SEQ ID NO:87: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:87: 2 UGUCCCUCAG CCAGC INFORMATION FOR SEQ ID NO:88: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:88: AGCGAAUAAA GGAAU INFORMATION FOR SEQ ID NO:89: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:89: UUAGAAUUUG CAGAA S..i INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs S* TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID CAGCUAUCAA AAGGU INFORMATION FOR SEQ ID NO:91: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:91: ACACCAUUCA AACAU INFORMATION FOR SEQ ID NO:92: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:92: CACCAUUCAA ACAUG INFORMATION FOR SEQ ID NO:93: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:93: 12 2 AUACGGUCCC CUGAA INFORMATION FOR SEQ ID NO:94: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:94: CUGGAAUUGU UGCUG INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID S GAAUUGUUGC UGAGU INFORMATION FOR SEQ ID NO:96: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:96: AUAUUCUUAC AAGCU INFORMATION FOR SEQ ID NO:97: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single e TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:97: UCCGUUUUAA UGGCA INFORMATION FOR SEQ ID NO:98: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:98: ACAAUGUUCU CAAAG INFORMATION FOR SEQ ID NO:99: SEQUENCE CHARACTERISTICS: LENGTH: 14 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:99: ACGGUCCCCU GAAG 14 INFORMATION FOR SEQ ID NO:100: SEQUENCE CHARACTERISTICS: LENGTH: 14 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:100: ACAGUUGAGA GCAG 14 INFORMATION FOR SEQ ID NO:101: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:101: UUUCCCCCUG AUGAGGCCGA AAGGCCGAAA GUGACG 36 INFORMATION FOR SEQ ID NO:102: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:102: SUUGGCAACUG AUGAGGCCGA AAGGCCGAAA ACAGAC 36

S

INFORMATION FOR SEQ ID NO:103: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:103: GCUUGGCCUG AUGAGGCCGA AAGGCCGAAA UAACAG 36 INFORMATION FOR SEQ ID NO:104: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:104: GCUUUCCCUG AUGAGGCCGA AAGGCCGAAA UUCUCC 36 INFORMATION FOR SEQ ID NO:105: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid 124 STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:105: UGUCCAGCUG AUGAGGCCGA AAGGCCGAAA GGUUUU 36 INFORMATION FOR SEQ ID NO:106: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:106: UUCUUGACUG AUGAGGCCGA AAGGCCGAAA GCAUUA 36 INFORMATION FOR SEQ ID NO:107: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:107: UCUUCUGCUG AUGAGGCCGA AAGGCCGAAA AGCUCG 36 INFORMATION FOR SEQ ID NO:108: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs S* TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:108: AUGUGGUCUG AUGAGGCCGA AAGGCCGAAA UAGGAA 36 INFORMATION FOR SEQ ID NO:109: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:109: GCCGGCUCUG AUGAGCGCGA AAGCGCGAAA GGGACG 36 INFORMATION FOR SEQ ID NO:110: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:110: GCUCCUUCUG AUGAGGCCGA AAGGCCGAAA UUCGCU 36 INFORMATION FOR SEQ ID NO:111: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:111: UUCUGCACUG AUGAGGCCGA AAGGCCGAAA UUCUAA 36 INFORMATION FOR SEQ ID NO:112: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:112: ACCUUUUCUG AUGAGGCCGA AAGGCCGAAA UAGCUG 36 INFORMATION FOR SEQ ID NO:113: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:113: AUGUUUGCUG AUGAGGCCGA AAGGCCGAAA UGGUGU 36 INFORMATION FOR SEQ ID NO:114: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:114: CAUGUUUCUG AUGAGGCCGA AAGGCCGAAA AUGGUG 36 INFORMATION FOR SEQ ID NO:115: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:115: UUCAGGGCUG AUGAGGCCGA AAGGCCGAAA CCGUAU 36 INFORMATION FOR SEQ ID NO:116: SEQUENCE

CHARACTERISTICS:

LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:116: CAGCAACCUG AUGAGGCCGA AAGGCCGAAA UUCCAG 36 INFORMATION FOR SEQ ID NO:117: tzG SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:117: ACUCAGCCUG AUGAGGCCGA AAGGCCGAAA CAAUUC 36 INFORMATION FOR SEQ ID NO:118: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:118: AGCUUGUCUG AUGAGGCCGA AAGGCCGAAA GAAUAU 36 INFORMATION FOR SEQ ID NO:119: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 9 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:119: UGUCAUUCUG AUGAGGCCGA AAGGCCGAAA AACAGA 36 INFORMATION FOR SEQ ID NO:120: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid too. STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:120: CUUUGAGCUG AUGAGGCCGA AAGGCCGAAA CAUUGU 36 INFORMATION FOR SEQ ID NO:121: SEQUENCE CHARACTERISTICS: LENGTH: 53 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:121: UCAGGGAGAA GUAUACCAGA GAAACACACG CGCGCGUGGU ACAUUACCUG GUA 53 INFORMATION FOR SEQ ID NO:122: SEQUENCE CHARACTERISTICS: LENGTH: 53 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:122: GCUCUCAGAA GUUGACCAGA GAAACACACG CGCGCGUGGU ACAUUACCUG GUA 53 127 INFORMATION FOR SEQ ID NO:123: SEQUENCE CHARACTERISTICS: LENGTH: 34 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:123: CUUUCCCUGA UGAGGCCGAA AGGCCGAAAU UCUC 34 INFORMATION FOR SEQ ID NO:124: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:124: UGCUUUCCCU GAUGAGGCCG AAAGGCCGAA AUUCUCCC 38 INFORMATION FOR SEQ ID NO:125: SEQUENCE CHARACTERISTICS: LENGTH: 40 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:125: CUGCUUUCCC UGAUGAGGCC GAAAGGCCGA AAUUCUCCCU INFORMATION FOR SEQ ID NO:126: SEQUENCE CHARACTERISTICS: LENGTH: 42 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:126: ACUGCUUUCC CUGAUGAGGC CGAAAGGCCG AAAUUCUCCC UU 42 INFORMATION FOR SEQ ID NO:127: SEQUENCE CHARACTERISTICS: LENGTH: 46 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:127: ACACUGCUUU CCCUGAUGAG GCCGAAAGGC CGAAAUUCUC CCUUUU 46 INFORMATION FOR SEQ ID NO:128: SEQUENCE CHARACTERISTICS: LENGTH: 46 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:128: AGUGCUUGGC AACUGAUGAG GCCGAAAGGC CGAAAACAGA CCAACG 46 INFORMATION FOR SEQ ID NO:129: SEQUENCE CHARACTERISTICS: LENGTH: 46 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:129: GAUUGACCUU UUCUGAUGAG GCCGAAAGGC CGAAAUAGCU GGAGUU 46 INFORMATION FOR SEQ ID NO:130: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:130: CCCUCCCCAG AAGCGCACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 o*o*oo INFORMATION FOR SEQ ID NO:131: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs 5 TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:131: GCGCAGCCGG GGAGGG 16 INFORMATION FOR SEQ ID NO:132: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:132: ACCGACCGAG AAGCCGACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:133: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:133: CGGCAGCCCG GUCGGU 16 INFORMATION FOR SEQ ID NO:134: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 2C (xi) SEQUENCE DESCRIPTION: SEQ ID NO:134: GCGCGGCGAG AAGCGGACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:135: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:135: CCGCCGCCCG CCGCGC 16 INFORMATION FOR SEQ ID NO:136: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:136: ACGUUUCGAG AAGUAUACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:137: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:137: AUACGGUCCG AAACGU 16 INFORMATION FOR SEQ ID NO:138: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:138: UUCGUCCAAG AAGUAGACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:139: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:139: CUACUGCCUG GACGAA 16 INFORMATION FOR SEQ ID NO:140: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:140: AUGGCUGCAG AAGCUGACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:141: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:141: CAGCUGCCGC AGCCAU 16 INFORMATION FOR SEQ ID NO:142: SEQUENCE CHARACTERISTICS: o. LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:142: CUGGUGUGAG AAGCAAACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 0 INFORMATION FOR SEQ ID NO:143: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:143: UUGCCGACCA CACCAG 16 INFORMATION FOR SEQ ID NO:144: SEQUENCE CHARACTERISTICS: O LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:144: GUUCUAAAAG AAGUAUACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:145: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:145: AUACUGUUUU UAGAAC 16 INFORMATION FOR SEQ ID NO:146: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:146: CUUCAGGGAG AAGUAUACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:147: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:147: AUACGGUCCC CUGAAG 16 INFORMATION FOR SEQ ID NO:148: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:148: GGUAUUCAAG AAGUCCACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:149: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:149: GGACAGUCUG AAUACC 16 INFORMATION FOR SEQ ID NO:150: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:150: UCUGCGUGAG AAGUUGACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:151: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:151: CAACUGUUCA CGCAGA 16 132 INFORMATION FOR SEQ ID NO:152: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:152: CAGGCGAGAG AAGCGUACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:153: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:153: ACGCAGACCU CGCCUG 16 INFORMATION FOR SEQ ID NO:154: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:154: UGCUACAAAG AAGCAAACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:155: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:155: S UUGCAGCCUU GUAGCA 16 INFORMATION FOR SEQ ID NO:156: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:156: CUGCUCUCAG AAGUUGACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:157: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:157: CAACAGUUGA GAGCAG 1c 1 33 INFORMATION FOR SEQ ID NO:158: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:158: UUAGGUAAAG AAGUUAACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:159: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:159: UAACAGUCUU ACCUAA 16 INFORMATION FOR SEQ ID NO:160: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:160: .AAUUAUAAAG AAGUCAACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:161: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear .4 *4 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:161: UGACUGUUUU AUAAUU 16 INFORMATION FOR SEQ ID NO:162: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:162: AUCCAUGCAG AAGUUCACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:163: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:163: t3^ GAACUGUUGC AUGGAU 16 INFORMATION FOR SEQ ID NO:164: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:164: GUUCUUAAAG AAGUGAACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:165: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:165: UCACUGCCUU AAGAAC 16 INFORMATION FOR SEQ ID NO:166: SEQUENCE CHARACTERISTICS: LENGTH: 52 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:166: UGCUACAAAG AAGUAAACCA GAGAAACACA CGUUGUGGUA CAUUACCUGG UA 52 INFORMATION FOR SEQ ID NO:167: oe'. SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:167: UUACUGCCUU GUAGCA 16 INFORMATION FOR SEQ ID NO:168: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:168: CAACCUGUUU CCUCCUC 17 INFORMATION FOR SEQ ID NO:169: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:169: GAGGAGGACU GAUGAGGCCG AAAGGCCGAA ACAGGUUG 38 INFORMATION FOR SEQ ID NO:170: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:170: AACCUGUUUC CUCCUCC 17 INFORMATION FOR SEQ ID NO:171: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:171: S GGAGGAGGCU GAUGAGGCCG AAAGGCCGAA AACAGGUU 38 9* INFORMATION FOR SEQ ID NO:172: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:172: SACCUGUUUCC UCCUCCU 17 INFORMATION FOR SEQ ID NO:173: SEQUENCE CHARACTERISTICS: S* LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:173: AGGAGGAGCU GAUGAGGCCG AAAGGCCGAA AAACAGGU 38 INFORMATION FOR SEQ ID NO:174: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:174: UGUUUCCUCC UCCUCCU 17 INFORMATION FOR SEQ ID NO:175: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:175: AGGAGGAGCU GAUGAGGCCG AAAGGCCGAA AGGAAACA 38 INFORMATION FOR SEQ ID NO:176: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:176: UUCCUCCUCC UCCUUCU 17 INFORMATION FOR SEQ ID NO:177: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:177: AGAAGGAGCU GAUGAGGCCG AAAGGCCGAA AGGAGGAA 38 INFORMATION FOR SEQ ID NO:178: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:178: CUCCUCCUCC UUCUCCU 17 INFORMATION FOR SEQ ID NO:179: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:179: AGGAGAAGCU GAUGAGGCCG AAAGGCCGAA AGGAGGAG 38 INFORMATION FOR SEQ ID NO:180: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:180: CUCCUCCUUC UCCUCCU 17 INFORMATION FOR SEQ ID NO:181: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs t37 TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:181: AGGAGGAGCU GAUGAGGCCG AAAGGCCGAA AGGAGGAG 38 INFORMATION FOR SEQ ID NO:182: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:182: UCCUCCUUCU CCUCCUC 17 INFORMATION FOR SEQ ID NO:183: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:183: GAGGAGGACU GAUGAGGCCG AAAGGCCGAA AAGGAGGA 38 INFORMATION FOR SEQ ID NO:184: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:184: CUCCUUCUCC UCCUCCU 17 INFORMATION FOR SEQ ID NO:185: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:185: AGGAGGAGCU GAUGAGGCCG AAAGGCCGAA AGAAGGAG 38 INFORMATION FOR SEQ ID NO:186: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:186: CUUCUCCUCC UCCUCCG 17 INFORMATION FOR SEQ ID NO:187: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:187: CGGAGGAGCU GAUGAGGCCG AAAGGCCGAA AGGAGAAG 38 INFORMATION FOR SEQ ID NO:188: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:188: CUCCUCCUCC UCCGUGA 17 INFORMATION FOR SEQ ID NO:189: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:189: UCACGGAGCU GAUGAGGCCG AAAGGCCGAA AGGAGGAG 38 INFORMATION FOR SEQ ID NO:190: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:190: S CUCCUCCUCC GUGACCU 17 INFORMATION FOR SEQ ID NO:191: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:191: AGGUCACGCU GAUGAGGCCG AAAGGCCGAA AGGAGGAG 38 INFORMATION FOR SEQ ID NO:192: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:192: CGUGACCUCC UCCUCCU INFORMATION FOR SEQ ID NO:193: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:193: AGGAGGAGCU GAUGAGGCCG AAAGGCCGAA AGGUCACG 38 INFORMATION FOR SEQ ID NO:194: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:194: GACCUCCUCC UCCUCUU 17 INFORMATION FOR SEQ ID NO:195: S* SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear a (xi) SEQUENCE DESCRIPTION: SEQ ID NO:195: AAGAGGAGCU GAUGAGGCCG AAAGGCCGAA AGGAGGUC 38

S

INFORMATION FOR SEQ ID NO:196: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:196: CUCCUCCUCC UCUUUCU 17 17 INFORMATION FOR SEQ ID NO:197: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:197: AGAAAGAGCU GAUGAGGCCG AAAGGCCGAA AGGAGGAG 38 INFORMATION FOR SEQ ID NO:198: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:198: CUCCUCCUCU UUCUCCU 14-0 INFORMATION FOR SEQ ID NO:199: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:199: AGGAGAAACU GAUGAGGCCG AAAGGCCGAA AGGAGGAG 38 INFORMATION FOR SEQ ID NO:200: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:200: CCUCCUCUUU CUCCUGA 17 INFORMATION FOR SEQ ID NO:201: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:201: UCAGGAGACU GAUGAGGCCG AAAGGCCGAA AGAGGAGG 38 INFORMATION FOR SEQ ID NO:202: \09 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:202: CUCCUCUUUC UCCUGAG 17 INFORMATION FOR SEQ ID NO:203: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:203: CUCAGGAGCU GAUGAGGCCG AAAGGCCGAA AAGAGGAG 38 INFORMATION FOR SEQ ID NO:204: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:204: 14 UCCUCUUUCU CCUGAGA 17 INFORMATION FOR SEQ ID NO:205: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:205: UCUCAGGACU GAUGAGGCCG AAAGGCCGAA AAAGAGGA 38 INFORMATION FOR SEQ ID NO:206: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:206: CUCUUUCUCC UGAGAAA 17 see*: INFORMATION FOR SEQ ID NO:207: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:207: UUUCUCAGCU GAUGAGGCCG AAAGGCCGAA AGAAAGAG 38 INFORMATION FOR SEQ ID NO:208: •0 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:208: GAGAAACUUC GCCCCAG 17 INFORMATION FOR SEQ ID NO:209: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:209: CUGGGGCGCU GAUGAGGCCG AAAGGCCGAA AGUUUCUC 38 INFORMATION FOR SEQ ID NO:210: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear

L

14-2 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:210: AGAAACUUCG CCCCAGC 17 INFORMATION FOR SEQ ID NO:211: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:211: GCUGGGGCCU GAUGAGGCCG AAAGGCCGAA AAGUUUCU 38 INFORMATION FOR SEQ ID NO:212: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:212: AGCCCGGUCG GUCCCCG 17 INFORMATION FOR SEQ ID NO:213: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:213: CGGGGACCCU GAUGAGGCCG AAAGGCCGAA ACCGGGCU 38 INFORMATION FOR SEQ ID NO:214: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:214: CGGUCGGUCC CCGCGGC 17 INFORMATION FOR SEQ ID NO:215: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:215: GCCGCGGGCU GAUGAGGCCG AAAGGCCGAA ACCGACCG 38 INFORMATION FOR SEQ ID NO:216: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single 143 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:216: CCGCGGCUCU CGCGGAG 17 INFORMATION FOR SEQ ID NO:217: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:217: CUCCGCGACU GAUGAGGCCG AAAGGCCGAA AGCCGCGG 38 INFORMATION FOR SEQ ID NO:218: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:218: S: GCGGCUCUCG CGGAGCC 17 INFORMATION FOR SEQ ID NO:219: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:219: GGCUCCGCCU GAUGAGGCCG AAAGGCCGAA AGAGCCGC 38 INFORMATION FOR SEQ ID NO:220: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:220: CACAGCAUAU AUAGCAG 17 INFORMATION FOR SEQ ID NO:221: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:221: CUGCUAUACU GAUGAGGCCG AAAGGCCGAA AUGCUGUG 38 INFORMATION FOR SEQ ID NO:222: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs 14-4 TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:222: CAGCAUAUAU AGCAGUG 17 INFORMATION FOR SEQ ID NO:223: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:223: CACUGCUACU GAUGAGGCCG AAAGGCCGAA AUAUGCUG 38 INFORMATION FOR SEQ ID NO:224: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:224: GCAUAUAUAG CAGUGAC 17 INFORMATION FOR SEQ ID NO:225: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:225: GUCACUGCCU GAUGAGGCCG AAAGGCCGAA AUAUAUGC 38 INFORMATION FOR SEQ ID NO:226: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:226: UGAGGACUUU GAGAUGU 17 INFORMATION FOR SEQ ID NO:227: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:227: ACAUCUCACU GAUGAGGCCG AAAGGCCGAA AGUCCUCA 38 INFORMATION FOR SEQ ID NO:228: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:228: GAGGACUUUG AGAUGUG 17 INFORMATION FOR SEQ ID NO:229: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:229: CACAUCUCCU GAUGAGGCCG AAAGGCCGAA AAGUCCUC 38 INFORMATION FOR SEQ ID NO:230: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:230: CCAUGACUAU GAUGGGC 17 INFORMATION FOR SEQ ID NO:231: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:231: GCCCAUCACU GAUGAGGCCG AAAGGCCGAA AGUCAUGG 38 INFORMATION FOR SEQ ID NO:232: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:232: GGGCUGCUUC CCAAGUC 17 INFORMATION FOR SEQ ID NO:233: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:233: GACUUGGGCU GAUGAGGCCG AAAGGCCGAA AGCAGCCC 38 14-0 INFORMATION FOR SEQ ID NO:234: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:234: GGCUGCUUCC CAAGUCU 17 INFORMATION FOR SEQ ID NO:235: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:235: AGACUUGGCU GAUGAGGCCG AAAGGCCGAA AAGCAGCC 38 INFORMATION FOR SEQ ID NO:236: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:236: UCCCAAGUCU GGAAAGC 17 INFORMATION FOR SEQ ID NO:237: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:237: GCUUUCCACU GAUGAGGCCG AAAGGCCGAA ACUUGGGA 38 INFORMATION FOR SEQ ID NO:238: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:238: GAAAGCGUCA CUUGGGG 17 INFORMATION FOR SEQ ID NO:239: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:239: 147 CCCCAAGUCU GAUGAGGCCG AAAGGCCGAA ACGCUUUC 38 INFORMATION FOR SEQ ID NO:240: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:240: GCGUCACUUG GGGAAAA 17 INFORMATION FOR SEQ ID NO:241: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:241: UUUUCCCCCU GAUGAGGCCG AAAGGCCGAA AGUGACGC 38 INFORMATION FOR SEQ ID NO:242: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:242: S UGGAAAGUUA UUGCCAA 17 INFORMATION FOR SEQ ID NO:243: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:243: UUGGCAAUCU GAUGAGGCCG AAAGGCCGAA ACUUUCCA 38 INFORMATION FOR SEQ ID NO:244: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:244: GGAAAGUUAU UGCCAAU 17 INFORMATION FOR SEQ ID NO:245: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 1-S (xi) SEQUENCE DESCRIPTION: SEQ ID NO:245: AUUGGCAACU GAUGAGGCCG AAAGGCCGAA AACUUUCC 38 INFORMATION FOR SEQ ID NO:246: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:246: AAAGUUAUUG CCAAUUA 17 INFORMATION FOR SEQ ID NO:247: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear *o (xi) SEQUENCE DESCRIPTION: SEQ ID NO:247: UAAUUGGCCU GAUGAGGCCG AAAGGCCGAA AUAACUUU 38 INFORMATION FOR SEQ ID NO:248: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:248: UUGCCAAUUA UCUCCCG 17 **1 o.0 INFORMATION FOR SEQ ID NO:249: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:249: CGGGAGAUCU GAUGAGGCCG AAAGGCCGAA AUUGGCAA 38 INFORMATION FOR SEQ ID NO:250: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:250: UGCCAAUUAU CUCCCGA 17 INFORMATION FOR SEQ ID NO:251: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:251: UCGGGAGACU GAUGAGGCCG AAAGGCCGAA AAUUGGCA 38 INFORMATION FOR SEQ ID NO:252: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:252: CCAAUUAUCU CCCGAAU 17 INFORMATION FOR SEQ ID NO:253: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:253: AUUCGGGACU GAUGAGGCCG AAAGGCCGAA AUAAUUGG 38 INFORMATION FOR SEQ ID NO:254: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear o (xi) SEQUENCE DESCRIPTION: SEQ ID NO:254: UCCCGAAUCG AACAGAU 17 INFORMATION FOR SEQ ID NO:255: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:255: AUCUGUUCCU GAUGAGGCCG AAAGGCCGAA AUUCGGGA 38 INFORMATION FOR SEQ ID NO:256: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:256: CAGAAAGUAC UAAACCC 17 INFORMATION FOR SEQ ID NO:257: 150 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:257: GGGUUUAGCU GAUGAGGCCG AAAGGCCGAA ACUUUCUG 38 INFORMATION FOR SEQ ID NO:258: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:258: AAAGUACUAA ACCCUGA 17 INFORMATION FOR SEQ ID NO:259: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:259: UCAGGGUUCU GAUGAGGCCG AAAGGCCGAA AGUACUUU 38 INFORMATION FOR SEQ ID NO:260: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:260: CCUGAGCUCA UCAAGGG INFORMATION FOR SEQ ID NO:261: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:261: CCCUUGAUCU GAUGAGGCCG AAAGGCCGAA AGCUCAGG 38 INFORMATION FOR SEQ ID NO:262: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:262: GAGCUCAUCA AGGGUCC 17 INFORMATION FOR SEQ ID NO:263: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:263: GGACCCUUCU GAUGAGGCCG AAAGGCCGAA AUGAGCUC 38 INFORMATION FOR SEQ ID NO:264: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:264: UCAAGGGUCC UUGGACC 17 INFORMATION FOR SEQ ID NO:265: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:265: GGUCCAAGCU GAUGAGGCCG AAAGGCCGAA ACCCUUGA 38 INFORMATION FOR SEQ ID NO:266: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:266: SAGGGUCCUUG GACCAAA 17 INFORMATION FOR SEQ ID NO:267: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:267: UUUGGUCCCU GAUGAGGCCG AAAGGCCGAA AGGACCCU 38 INFORMATION FOR SEQ ID NO:268: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:268: AAGAAGAUCA GAGAGUG 17 152 INFORMATION FOR SEQ ID NO:269: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:269: CACUCUCUCU GAUGAGGCCG AAAGGCCGAA AUCUUCUU 38 INFORMATION FOR SEQ ID NO:270: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:270: AGAGUGAUAG AGCUUGU 17 INFORMATION FOR SEQ ID NO:271: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:271: ACAAGCUCCU GAUGAGGCCG AAAGGCCGAA AUCACUCU 38 INFORMATION FOR SEQ ID NO:272: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 99 *e (xi) SEQUENCE DESCRIPTION: SEQ ID NO:272: AUAGAGCUUG UACAGAA 17 INFORMATION FOR SEQ ID NO:273: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:273: UUCUGUACCU GAUGAGGCCG AAAGGCCGAA AGCUCUAU 38 INFORMATION FOR SEQ ID NO:274: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:274: r53 GAGCUUGUAC AGAAAUA 17 INFORMATION FOR SEQ ID NO:275: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:275: UAUUUCUGCU GAUGAGGCCG AAAGGCCGAA ACAAGCUC 38 INFORMATION FOR SEQ ID NO:276: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:276: ACAGAAAUAC GGUCCGA 17 INFORMATION FOR SEQ ID NO:277: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:277: UCGGACCGCU GAUGAGGCCG AAAGGCCGAA AUUUCUGU 38 INFORMATION FOR SEQ ID NO:278: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:278: AAUACGGUCC GAAACGU 17 INFORMATION FOR SEQ ID NO:279: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:279: ACGUUUCGCU GAUGAGGCCG AAAGGCCGAA ACCGUAUU 38 INFORMATION FOR SEQ ID NO:280: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S4- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:280: CGAAACGUUG GUCUGUU 17 INFORMATION FOR SEQ ID NO:281: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:281: AACAGACCCU GAUGAGGCCG AAAGGCCGAA ACGUUUCG 38 INFORMATION FOR SEQ ID NO:282: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:282: ACGUUGGUCU GUUAUUG 17 17 INFORMATION FOR SEQ ID NO:283: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:283: CAAUAACACU GAUGAGGCCG AAAGGCCGAA ACCAACGU 38 INFORMATION FOR SEQ ID NO:284: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 17 base pairs TYPE: nucleic acid S* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:284: UGGUCUGUUA UUGCCAA 17 INFORMATION FOR SEQ ID NO:285: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:285: UUGGCAAUCU GAUGAGGCCG AAAGGCCGAA ACAGACCA 38 INFORMATION FOR SEQ ID NO:286: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single 155 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:286: GGUCUGUUAU UGCCAAG 17 INFORMATION FOR SEQ ID NO:287: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:287: CUUGGCAACU GAUGAGGCCG AAAGGCCGAA AACAGACC 38 INFORMATION FOR SEQ ID NO:288: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:288: SUCUGUUAUUG CCAAGCA 17 INFORMATION FOR SEQ ID NO:289: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:289: UGCUUGGCCU GAUGAGGCCG AAAGGCCGAA AUAACAGA 38 INFORMATION FOR SEQ ID NO:290: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:290: CAAGCACUUA AAGGGGA 17 INFORMATION FOR SEQ ID NO:291: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:291: UCCCCUUUCU GAUGAGGCCG AAAGGCCGAA AGUGCUUG 38 INFORMATION FOR SEQ ID NO:292: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:292: AAGCACUUAA AGGGGAG 17 INFORMATION FOR SEQ ID NO:293: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:293: CUCCCCUUCU GAUGAGGCCG AAAGGCCGAA AAGUGCUU 38 INFORMATION FOR SEQ ID NO:294: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:294: GGGAGAAUUG GAAAACA 17 INFORMATION FOR SEQ ID NO:295: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:295: UGUUUUCCCU GAUGAGGCCG AAAGGCCGAA AUUCUCCC 38 INFORMATION FOR SEQ ID NO:296: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:296: AACAAUGUAG GGAGAGG 17 INFORMATION FOR SEQ ID NO:297: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:297: CCUCUCCCCU GAUGAGGCCG AAAGGCCGAA ACAUUGUU 38 INFORMATION FOR SEQ ID NO:298: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:298: GGUGGCAUAA CCACUUG 17 INFORMATION FOR SEQ ID NO:299: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:299: CAAGUGGUCU GAUGAGGCCG AAAGGCCGAA AUGCCACC 38 INFORMATION FOR SEQ ID NO:300: SEQUENCE CHARACTERISTICS: S. LENGTH: 17 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:300: S: ACUUGAAUCC AGAAGUU 17 INFORMATION FOR SEQ ID NO:301: SEQUENCE CHARACTERISTICS: *o LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:301: AACUUCUGCU GAUGAGGCCG AAAGGCCGAA AUUCAAGU 38 INFORMATION FOR SEQ ID NO:302: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:302: CCAGAAGUUA AGAAAAC 17 INFORMATION FOR SEQ ID NO:303: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:303: GUUUUCUUCU GAUGAGGCCG AAAGGCCGAA ACUUCUGG 38 INFORMATION FOR SEQ ID NO:304: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:304: CAGAAGUUAA GAAAACC 17 INFORMATION FOR SEQ ID NO:305: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:305: GGUUUUCUCU GAUGAGGCCG AAAGGCCGAA AACUUCUG 38 INFORMATION FOR SEQ ID NO:306: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:306: GAAAACCUCC UGGACAG 17 INFORMATION FOR SEQ ID NO:307: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:307: CUGUCCAGCU GAUGAGGCCG AAAGGCCGAA AGGUUUUC 38 INFORMATION FOR SEQ ID NO:308: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:308: GACAGAAUUA UUUACCA 17 INFORMATION FOR SEQ ID NO:309: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:309: UGGUAAAUCU GAUGAGGCCG AAAGGCCGAA AUUCUGUC 38 INFORMATION FOR SEQ ID NO:310: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:310: ACAGAAUUAU UUACCAG 17 INFORMATION FOR SEQ ID NO:311: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:311: CUGGUAAACU GAUGAGGCCG AAAGGCCGAA AAUUCUGU 38 INFORMATION FOR SEQ ID NO:312: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:312: AGAAUUAUUU ACCAGGC 17 INFORMATION FOR SEQ ID NO:313: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:313: GCCUGGUACU GAUGAGGCCG AAAGGCCGAA AUAAUUCU 38 INFORMATION FOR SEQ ID NO:314: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:314: GAAUUAUUUA CCAGGCA 17 INFORMATION FOR SEQ ID NO:315: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:315: UGCCUGGUCU GAUGAGGCCG AAAGGCCGAA AAUAAUUC 38 INFORMATION FOR SEQ ID NO:316: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:316: AAUUAUUUAC CAGGCAC 17 INFORMATION FOR SEQ ID NO:317: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:317: GUGCCUGGCU GAUGAGGCCG AAAGGCCGAA AAAUAAUU 38 INFORMATION FOR SEQ ID NO:318: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:318: o* GCAGAAAUCG CAAAGCU 17 INFORMATION FOR SEQ ID NO:319: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:319: AGCUUUGCCU GAUGAGGCCG AAAGGCCGAA AUUUCUGC 38 INFORMATION FOR SEQ ID NO:320: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:320: GCAAAGCUAC UGCCUGG 17 INFORMATION FOR SEQ ID NO:321: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:321: CCAGGCAGCU GAUGAGGCCG AAAGGCCGAA AGCUUUGC 38 INFORMATION FOR SEQ ID NO:322: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:322: GAACUGAUAA UGCUAUC 17 INFORMATION FOR SEQ ID NO:323: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:323: S GAUAGCAUCU GAUGAGGCCG AAAGGCCGAA AUCAGUUC 38 INFORMATION FOR SEQ ID NO:324: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:324: AUAAUGCUAU CAAGAAC 17 INFORMATION FOR SEQ ID NO:325: SEQUENCE CHARACTERISTICS: S* LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:325: GUUCUUGACU GAUGAGGCCG AAAGGCCGAA AGCAUUAU 38 INFORMATION FOR SEQ ID NO:326: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:326: AAUGCUAUCA AGAACCA 17 INFORMATION FOR SEQ ID NO:327: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:327: UGGUUCUUCU GAUGAGGCCG AAAGGCCGAA AUAGCAUU 38 INFORMATION FOR SEQ ID NO:328: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:328: ACUGGAAUUC UACAAUG 17 INFORMATION FOR SEQ ID NO:329: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear *8 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:329: CAUUGUAGCU GAUGAGGCCG AAAGGCCGAA AUUCCAGU 38 INFORMATION FOR SEQ ID NO:330: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:330: S CUGGAAUUCU ACAAUGC 17 INFORMATION FOR SEQ ID NO:331: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:331: GCAUUGUACU GAUGAGGCCG AAAGGCCGAA AAUUCCAG 38 INFORMATION FOR SEQ ID NO:332: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:332: GGAAUUCUAC AAUGCGU 17 INFORMATION FOR SEQ ID NO:333: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:333: ACGCAUUGCU GAUGAGGCCG AAAGGCCGAA AGAAUUCC 38 INFORMATION FOR SEQ ID NO:334: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:334: CAAUGCGUCG GAAGGUC 17 INFORMATION FOR SEQ ID NO:335: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:335: S GACCUUCCCU GAUGAGGCCG AAAGGCCGAA ACGCAUUG 38 INFORMATION FOR SEQ ID NO:336: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:336: CGGAAGGUCG AACAGGA 17 INFORMATION FOR SEQ ID NO:337: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:337: UCCUGUUCCU GAUGAGGCCG AAAGGCCGAA ACCUUCCG 38 INFORMATION FOR SEQ ID NO:338: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:338: AGGAAGGUUA UCUGCAG c034- INFORMATION FOR SEQ ID NO:339: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:339: CUGCAGAUCU GAUGAGGCCG AAAGGCCGAA ACCUUCCU 38 INFORMATION FOR SEQ ID NO:340: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:340: GGAAGGUUAU CUGCAGG 17 INFORMATION FOR SEQ ID NO:341: SEQUENCE CHARACTERISTICS: A) LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:341: CCUGCAGACU GAUGAGGCCG AAAGGCCGAA AACCUUCC 38 INFORMATION FOR SEQ ID NO:342: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:342: 0* AAGGUUAUCU GCAGGAG 17 INFORMATION FOR SEQ ID NO:343: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:343: CUCCUGCACU GAUGAGGCCG AAAGGCCGAA AUAACCUU 38 INFORMATION FOR SEQ ID NO:344: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:344: GCAGGAGUCU UCAAAAG 17 INFORMATION FOR SEQ ID NO:345: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:345: CUUUUGAACU GAUGAGGCCG AAAGGCCGAA ACUCCUGC 38 INFORMATION FOR SEQ ID NO:346: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:346: S AGGAGUCUUC AAAAGCC 17 S(2) INFORMATION FOR SEQ ID NO:347: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:347: GGCUUUUGCU GAUGAGGCCG AAAGGCCGAA AGACUCCU 38 INFORMATION FOR SEQ ID NO:348: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:348: GGAGUCUUCA AAAGCCA 17 INFORMATION FOR SEQ ID NO:349: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:349: UGGCUUUUCU GAUGAGGCCG AAAGGCCGAA AAGACUCC 38 INFORMATION FOR SEQ ID NO:350: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 1o (xi) SEQUENCE DESCRIPTION: SEQ ID NO:350: CACAAGCUUC CAGAAGA 17 INFORMATION FOR SEQ ID NO:351: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:351: UCUUCUGGCU GAUGAGGCCG AAAGGCCGAA AGCUUGUG 38 INFORMATION FOR SEQ ID NO:352: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:352: ACAAGCUUCC AGAAGAA 17 INFORMATION FOR SEQ ID NO:353: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:353: UUCUUCUGCU GAUGAGGCCG AAAGGCCGAA AAGCUUGU 38 INFORMATION FOR SEQ ID NO:354: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:354: AGAACAGUCA UUUGAUG 17 INFORMATION FOR SEQ ID NO:355: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:355: CAUCAAAUCU GAUGAGGCCG AAAGGCCGAA ACUGUUCU 38 INFORMATION FOR SEQ ID NO:356: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid O STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:356: ACAGUCAUUU GAUGGGU 17 INFORMATION FOR SEQ ID NO:357: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:357: ACCCAUCACU GAUGAGGCCG AAAGGCCGAA AUGACUGU 38 INFORMATION FOR SEQ ID NO:358: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:358: CAGUCAUUUG AUGGGUU 17 INFORMATION FOR SEQ ID NO:359: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:359: AACCCAUCCU GAUGAGGCCG AAAGGCCGAA AAUGACUG 38 INFORMATION FOR SEQ ID NO:360: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:360: UGAUGGGUUU UGCUCAG 17 INFORMATION FOR SEQ ID NO:361: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:361: CUGAGCAACU GAUGAGGCCG AAAGGCCGAA ACCCAUCA 38 INFORMATION FOR SEQ ID NO:362: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:362: GAUGGGUUUU GCUCAGG 17 INFORMATION FOR SEQ ID NO:363: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:363: CCUGAGCACU GAUGAGGCCG AAAGGCCGAA AACCCAUC 38 INFORMATION FOR SEQ ID NO:364: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S* TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:364: AUGGGUUUUG CUCAGGC 17 INFORMATION FOR SEQ ID NO:365: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:365: S GCCUGAGCCU GAUGAGGCCG AAAGGCCGAA AAACCCAU 38 INFORMATION FOR SEQ ID NO:366: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:366: GUUUUGCUCA GGCUCCG 17 INFORMATION FOR SEQ ID NO:367: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:367: CGGAGCCUCU GAUGAGGCCG AAAGGCCGAA AGCAAAAC 38 INFORMATION FOR SEQ ID NO:368: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:368: CUCAGGCUCC GCCUACA 17 INFORMATION FOR SEQ ID NO:369: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:369: UGUAGGCGCU GAUGAGGCCG AAAGGCCGAA AGCCUGAG 38 INFORMATION FOR SEQ ID NO:370: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:370: CUCCGCCUAC AGCUCAA 17 **oo e INFORMATION FOR SEQ ID NO:371: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:371: UUGAGCUGCU GAUGAGGCCG AAAGGCCGAA AGGCGGAG 38 INFORMATION FOR SEQ ID NO:372: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:372: CUACAGCUCA ACUCCCU 17 INFORMATION FOR SEQ ID NO:373: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:373: AGGGAGUUCU GAUGAGGCCG AAAGGCCGAA AGCUGUAG 38 J INFORMATION FOR SEQ ID NO:374: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:374: GCUCAACUCC CUGCCAC 17 INFORMATION FOR SEQ ID NO:375: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:375: GUGGCAGGCU GAUGAGGCCG AAAGGCCGAA AGUUGAGC 38 INFORMATION FOR SEQ ID NO:376: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S* TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:376: CCCACUGUUA ACAACGA 17 INFORMATION FOR SEQ ID NO:377: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single I TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:377: UCGUUGUUCU GAUGAGGCCG AAAGGCCGAA ACAGUGGG 38 INFORMATION FOR SEQ ID NO:378: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:378: CAACGACUAU UCCUAUU 17 INFORMATION FOR SEQ ID NO:379: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:379: S-7 S AAUAGGAACU GAUGAGGCCG AAAGGCCGAA AGUCGUUG 38 INFORMATION FOR SEQ ID NO:380: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:380: ACGACUAUUC CUAUUAC 17 INFORMATION FOR SEQ ID NO:381: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:381: GUAAUAGGCU GAUGAGGCCG AAAGGCCGAA AUAGUCGU 38 INFORMATION FOR SEQ ID NO:382: 99 *9 S(i) SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 9.* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:382: CGACUAUUCC UAUUACC 17 INFORMATION FOR SEQ ID NO:383: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:383: GGUAAUAGCU GAUGAGGCCG AAAGGCCGAA AAUAGUCG 38 INFORMATION FOR SEQ ID NO:384: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:384: CUAUUCCUAU UACCACA 17 INFORMATION FOR SEQ ID NO:385: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 1-72 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:385: UGUGGUAACU GAUGAGGCCG AAAGGCCGAA AGGAAUAG 38 INFORMATION FOR SEQ ID NO:386: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:386: AUUCCUAUUA CCACAUU 17 INFORMATION FOR SEQ ID NO:387: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:387: AAUGUGGUCU GAUGAGGCCG AAAGGCCGAA AUAGGAAU 38 INFORMATION FOR SEQ ID NO:388: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:388: UUCCUAUUAC CACAUUU 17 INFORMATION FOR SEQ ID NO:389: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:389: AAAUGUGGCU GAUGAGGCCG AAAGGCCGAA AAUAGGAA 38 INFORMATION FOR SEQ ID NO:390: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:390: UACCACAUUU CUGAAGC 17 INFORMATION FOR SEQ ID NO:391: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single -73 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:391: GCUUCAGACU GAUGAGGCCG AAAGGCCGAA AUGUGGUA 38 INFORMATION FOR SEQ ID NO:392: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:392: ACCACAUUUC UGAAGCA 17 INFORMATION FOR SEQ ID NO:393: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:393: UGCUUCAGCU GAUGAGGCCG AAAGGCCGAA AAUGUGGU 38 S* INFORMATION FOR SEQ ID NO:394: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:394: CCACAUUUCU GAAGCAC 17 INFORMATION FOR SEQ ID NO:395: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:395: GUGCUUCACU GAUGAGGCCG AAAGGCCGAA AAAUGUGG 38 INFORMATION FOR SEQ ID NO:396: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:396: CAAAAUGUCU CCAGUCA 17 INFORMATION FOR SEQ ID NO:397: SEQUENCE CHARACTERISTICS: S74- LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:397: UGACUGGACU GAUGAGGCCG AAAGGCCGAA ACAUUUUG 38 INFORMATION FOR SEQ ID NO:398: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:398: AAAUGUCUCC AGUCAUG 17 INFORMATION FOR SEQ ID NO:399: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:399: CAUGACUGCU GAUGAGGCCG AAAGGCCGAA AGACAUUU 38 INFORMATION FOR SEQ ID NO:400: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:400: UCUCCAGUCA UGUUCCA 17 INFORMATION FOR SEQ ID NO:401: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:401: UGGAACAUCU GAUGAGGCCG AAAGGCCGAA ACUGGAGA 38 INFORMATION FOR SEQ ID NO:402: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:402: AGUCAUGUUC CAUACCC 175 INFORMATION FOR SEQ ID NO:403: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:403: GGGUAUGGCU GAUGAGGCCG AAAGGCCGAA ACAUGACU 38 INFORMATION FOR SEQ ID NO:404: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:404: GUCAUGUUCC AUACCCU 17 INFORMATION FOR SEQ ID NO:405: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:405: AGGGUAUGCU GAUGAGGCCG AAAGGCCGAA AACAUGAC 38 INFORMATION FOR SEQ ID NO:406: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:406: UGUUCCAUAC CCUGUAG 17 INFORMATION FOR SEQ ID NO:407: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:407: CUACAGGGCU GAUGAGGCCG AAAGGCCGAA AUGGAACA 38 INFORMATION FOR SEQ ID NO:408: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:408: UACCCUGUAG CGUUACA 17 INFORMATION FOR SEQ ID NO:409: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:409: UGUAACGCCU GAUGAGGCCG AAAGGCCGAA ACAGGGUA 38 INFORMATION FOR SEQ ID NO:410: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:410: S. UGUAGCGUUA CAUGUAA 17 INFORMATION FOR SEQ ID NO:411: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:411: J UUACAUGUCU GAUGAGGCCG AAAGGCCGAA ACGCUACA 38 INFORMATION FOR SEQ ID NO:412: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid c* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:412: GUAGCGUUAC AUGUAAA 17 INFORMATION FOR SEQ ID NO:413: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:413: UUUACAUGCU GAUGAGGCCG AAAGGCCGAA AACGCUAC 38 INFORMATION FOR SEQ ID NO:414: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:414: S-77 AUGUAAAUAU AGUCAAU 17 INFORMATION FOR SEQ ID NO:415: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:415: AUUGACUACU GAUGAGGCCG AAAGGCCGAA AUUUACAU 38 INFORMATION FOR SEQ ID NO:416: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:416: GUAAAUAUAG UCAAUGU 17 INFORMATION FOR SEQ ID NO:417: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:417: ACAUUGACCU GAUGAGGCCG AAAGGCCGAA AUAUUUAC 38 INFORMATION FOR SEQ ID NO:418: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:418: AAUAUAGUCA AUGUCCC 17 INFORMATION FOR SEQ ID NO:419: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:419: GGGACAUUCU GAUGAGGCCG AAAGGCCGAA ACUAUAUU 38 INFORMATION FOR SEQ ID NO:420: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:420: GUCAAUGUCC CUCAGCC 17 INFORMATION FOR SEQ ID NO:421: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:421: GGCUGAGGCU GAUGAGGCCG AAAGGCCGAA ACAUUGAC 38 INFORMATION FOR SEQ ID NO:422: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:422: AUGUCCCUCA GCCAGCU 17 INFORMATION FOR SEQ ID NO:423: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:423: AGCUGGCUCU GAUGAGGCCG AAAGGCCGAA AGGGACAU 38 INFORMATION FOR SEQ ID NO:424: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:424: GCAGCCAUUC AGAGACA 17 INFORMATION FOR SEQ ID NO:425: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:425: UGUCUCUGCU GAUGAGGCCG AAAGGCCGAA AUGGCUGC 38 INFORMATION FOR SEQ ID NO:426: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single I 7) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:426: GAGACACUAU AAUGAUG 17 INFORMATION FOR SEQ ID NO:427: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:427: CAUCAUUACU GAUGAGGCCG AAAGGCCGAA AGUGUCUC 38 INFORMATION FOR SEQ ID NO:428: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:428: GACACUAUAA UGAUGAA 17 INFORMATION FOR SEQ ID NO:429: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:429: UUCAUCAUCU GAUGAGGCCG AAAGGCCGAA AUAGUGUC 38 INFORMATION FOR SEQ ID NO:430: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:430: AAGCGAAUAA AGGAAUU 17 INFORMATION FOR SEQ ID NO:431: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:431: AAUUCCUUCU GAUGAGGCCG AAAGGCCGAA AUUCGCUU 38 INFORMATION FOR SEQ ID NO:432: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:432: AAAGGAAUUA GAAUUGC 17 INFORMATION FOR SEQ ID NO:433: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:433: GCAAUUCUCU GAUGAGGCCG AAAGGCCGAA AUUCCUUU 38 INFORMATION FOR SEQ ID NO:434: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:434: SAAGGAAUUAG AAUUGCU 17 INFORMATION FOR SEQ ID NO:435: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:435: AGCAAUUCCU GAUGAGGCCG AAAGGCCGAA AAUUCCUU 38 INFORMATION FOR SEQ ID NO:436: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:436: AUUAGAAUUG CUCCUAA 17 INFORMATION FOR SEQ ID NO:437: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:437: UUAGGAGCCU GAUGAGGCCG AAAGGCCGAA AUUCUAAU 38 INFORMATION FOR SEQ ID NO:438: 1 ;3I SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:438: GAAUUGCUCC UAAUGUC 17 INFORMATION FOR SEQ ID NO:439: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:439: GACAUUAGCU GAUGAGGCCG AAAGGCCGAA AGCAAUUC 38 INFORMATION FOR SEQ ID NO:440: SEQUENCE CHARACTERISTICS: ev LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:440: UUGCUCCUAA UGUCAAC 17 INFORMATION FOR SEQ ID NO:441: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:441: GUUGACAUCU GAUGAGGCCG AAAGGCCGAA AGGAGCAA 38 INFORMATION FOR SEQ ID NO:442: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:442: CCUAAUGUCA ACCGAGA 17 INFORMATION FOR SEQ ID NO:443: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:443: UCUCGGUUCU GAUGAGGCCG AAAGGCCGAA ACAUUAGG 38 INFORMATION FOR SEQ ID NO:444: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:444: AAUGAGCUAA AAGGACA 17 INFORMATION FOR SEQ ID NO:445: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:445: UGUCCUUUCU GAUGAGGCCG AAAGGCCGAA AGCUCAUU 38 INFORMATION FOR SEQ ID NO:446: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:446: S ACCACCAUUG CCGACCA 17 INFORMATION FOR SEQ ID NO:447: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear ,o (xi) SEQUENCE DESCRIPTION: SEQ ID NO:447: UGGUCGGCCU GAUGAGGCCG AAAGGCCGAA AUGGUGGU 38 INFORMATION FOR SEQ ID NO:448: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:448: CCAGACCUCA UGGAGAC 17 INFORMATION FOR SEQ ID NO:449: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:449: GUCUCCAUCU GAUGAGGCCG AAAGGCCGAA AGGUCUGG 38 INFORMATION FOR SEQ ID NO:450: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:450: GCACCUGUUU CCUGUUU 17 INFORMATION FOR SEQ ID NO:451: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:451: 49 AAACAGGACU GAUGAGGCCG AAAGGCCGAA ACAGGUGC 38 INFORMATION FOR SEQ ID NO:452: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:452: CACCUGUUUC CUGUUUG 17 INFORMATION FOR SEQ ID NO:453: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:453: CAAACAGGCU GAUGAGGCCG AAAGGCCGAA AACAGGUG 38 INFORMATION FOR SEQ ID NO:454: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:454: ACCUGUUUCC UGUUUGG 17 INFORMATION FOR SEQ ID NO:455: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 1 €54- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:455: CCAAACAGCU GAUGAGGCCG AAAGGCCGAA AAACAGGU 38 INFORMATION FOR SEQ ID NO:456: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:456: UUUCCUGUUU GGGAGAA 17 INFORMATION FOR SEQ ID NO:457: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 9.

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:457: UUCUCCCACU GAUGAGGCCG AAAGGCCGAA ACAGGAAA 38 INFORMATION FOR SEQ ID NO:458: be SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S9 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:458: SUUCCUGUUUG GGAGAAC 17 INFORMATION FOR SEQ ID NO:459: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 9 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:459: GUUCUCCCCU GAUGAGGCCG AAAGGCCGAA AACAGGAA 38 INFORMATION FOR SEQ ID NO:460: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:460: ACACCACUCC ACUCCAU 17 INFORMATION FOR SEQ ID NO:461: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:461: AUGGAGUGCU GAUGAGGCCG AAAGGCCGAA AGUGGUGU 38 INFORMATION FOR SEQ ID NO:462: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:462: ACUCCACUCC AUCUCUG 17 INFORMATION FOR SEQ ID NO:463: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:463: CAGAGAUGCU GAUGAGGCCG AAAGGCCGAA AGUGGAGU 38 INFORMATION FOR SEQ ID NO:464: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:464: *o CACUCCAUCU CUGCCAG 17 o, INFORMATION FOR SEQ ID NO:465: SEQUENCE CHARACTERISTICS: *V LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:465: CUGGCAGACU GAUGAGGCCG AAAGGCCGAA AUGGAGUG 38 INFORMATION FOR SEQ ID NO:466: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:466: CUCCAUCUCU GCCAGCG 17 INFORMATION FOR SEQ ID NO:467: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:467: CGCUGGCACU GAUGAGGCCG AAAGGCCGAA AGAUGGAG 38 INFORMATION FOR SEQ ID NO:468: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:468: CAGCGGAUCC UGGCUCC 17 INFORMATION FOR SEQ ID NO:469: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:469: GGAGCCAGCU GAUGAGGCCG AAAGGCCGAA AUCCGCUG 38 INFORMATION FOR SEQ ID NO:470: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:470: UCCUGGCUCC CUACCUG 17 INFORMATION FOR SEQ ID NO:471: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:471: CAGGUAGGCU GAUGAGGCCG AAAGGCCGAA AGCCAGGA 38 INFORMATION FOR SEQ ID NO:472: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:472: GGCUCCCUAC CUGAAGA 17 INFORMATION FOR SEQ ID NO:473: !37 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:473: UCUUCAGGCU GAUGAGGCCG AAAGGCCGAA AGGGAGCC 38 INFORMATION FOR SEQ ID NO:474: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:474: AAGCGCCUCG CCAGCAA 17 INFORMATION FOR SEQ ID NO:475: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:475: UUGCUGGCCU GAUGAGGCCG AAAGGCCGAA AGGCGCUU 38 INFORMATION FOR SEQ ID NO:476: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear o (xi) SEQUENCE DESCRIPTION: SEQ ID NO:476: UGCAUGAUCG UCCACCA 17 INFORMATION FOR SEQ ID NO:477: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:477: UGGUGGACCU GAUGAGGCCG AAAGGCCGAA AUCAUGCA 38 INFORMATION FOR SEQ ID NO:478: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:478: AUGAUCGUCC ACCAGGG 17 INFORMATION FOR SEQ ID NO:479: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:479: CCCUGGUGCU GAUGAGGCCG AAAGGCCGAA ACGAUCAU 38 INFORMATION FOR SEQ ID NO:480: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:480: GGCACCAUUC UGGAUAA 17 INFORMATION FOR SEQ ID NO:481: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:481: UUAUCCAGCU GAUGAGGCCG AAAGGCCGAA AUGGUGCC 38 INFORMATION FOR SEQ ID NO:482: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid oo. STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:482: S GCACCAUUCU GGAUAAU 17 INFORMATION FOR SEQ ID NO:483: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:483: AUUAUCCACU GAUGAGGCCG AAAGGCCGAA AAUGGUGC 38 INFORMATION FOR SEQ ID NO:484: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:484: _1 S UUCUGGAUAA UGUUAAG 17 INFORMATION FOR SEQ ID NO:485: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:485: CUUAACAUCU GAUGAGGCCG AAAGGCCGAA AUCCAGAA 38 INFORMATION FOR SEQ ID NO:486: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:486: S* GAUAAUGUUA AGAACCU 17 INFORMATION FOR SEQ ID NO:487: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:487: AGGUUCUUCU GAUGAGGCCG AAAGGCCGAA ACAUUAUC 38 INFORMATION FOR SEQ ID NO:488: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:488: AUAAUGUUAA GAACCUC 17 INFORMATION FOR SEQ ID NO:489: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:489: GAGGUUCUCU GAUGAGGCCG AAAGGCCGAA AACAUUAU 38 INFORMATION FOR SEQ ID NO:490: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 11 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:490: AAGAACCUCU UAGAAUU 17 INFORMATION FOR SEQ ID NO:491: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:491: AAUUCUAACU GAUGAGGCCG AAAGGCCGAA AGGUUCUU 38 INFORMATION FOR SEQ ID NO:492: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:492: GAACCUCUUA GAAUUUG 17 INFORMATION FOR SEQ ID NO:493: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:493: CAAAUUCUCU GAUGAGGCCG AAAGGCCGAA AGAGGUUC 38 INFORMATION FOR SEQ ID NO:494: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:494: AACCUCUUAG AAUUUGC 17 INFORMATION FOR SEQ ID NO:495: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:495: GCAAAUUCCU GAUGAGGCCG AAAGGCCGAA AAGAGGUU 38 INFORMATION FOR SEQ ID NO:496: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:496: CUUAGAAUUU GCAGAAA 17 INFORMATION FOR SEQ ID NO:497: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:497: UUUCUGCACU GAUGAGGCCG AAAGGCCGAA AUUCUAAG 38 INFORMATION FOR SEQ ID NO:498: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:498: UUAGAAUUUG CAGAAAC 17 INFORMATION FOR SEQ ID NO:499: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:499: GUUUCUGCCU GAUGAGGCCG AAAGGCCGAA AAUUCUAA 38 INFORMATION FOR SEQ ID NO:500: SEQUENCE CHARACTERISTICS: S* LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:500: GAAACACUCC AAUUUAU 17 INFORMATION FOR SEQ ID NO:501: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:501: AUAAAUUGCU GAUGAGGCCG AAAGGCCGAA AGUGUUUC 38 INFORMATION FOR SEQ ID NO:502: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:502: ACUCCAAUUU AUAGAUU 17 INFORMATION FOR SEQ ID NO:503: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:503: AAUCUAUACU GAUGAGGCCG AAAGGCCGAA AUUGGAGU 38 INFORMATION FOR SEQ ID NO:504: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:504: CUCCAAUUUA UAGAUUC 17 INFORMATION FOR SEQ ID NO:505: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:505: GAAUCUAUCU GAUGAGGCCG AAAGGCCGAA AAUUGGAG 38 INFORMATION FOR SEQ ID NO:506: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:506: UCCAAUUUAU AGAUUCU 17 INFORMATION FOR SEQ ID NO:507: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:507: AGAAUCUACU GAUGAGGCCG AAAGGCCGAA AAAUUGGA 38 a a a a INFORMATION FOR SEQ ID NO:508: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:508: CAAUUUAUAG AUUCUUU INFORMATION FOR SEQ ID NO:509: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:509: AAAGAAUCCU GAUGAGGCCG AAAGGCCGAA AUAAAUUG INFORMATION FOR SEQ ID NO:510: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:510: UUAUAGAUUC UUUCUUA INFORMATION FOR SEQ ID NO:511: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:511: UAAGAAAGCU GAUGAGGCCG AAAGGCCGAA AUCUAUAA INFORMATION FOR SEQ ID NO:512: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:512: UAUAGAUUCU UUCUUAA INFORMATION FOR SEQ ID NO:513: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:513: UUAAGAAACU GAUGAGGCCG AAAGGCCGAA AAUCUAUA INFORMATION FOR SEQ ID NO:514: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:514: UAGAUUCUUU CUUAAAC 17 INFORMATION FOR SEQ ID NO:515: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:515: GUUUAAGACU GAUGAGGCCG AAAGGCCGAA AGAAUCUA 38 INFORMATION FOR SEQ ID NO:516: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S" TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:516: AGAUUCUUUC UUAAACA 17 INFORMATION FOR SEQ ID NO:517: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single "O TOPOLOGY: linear 0 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:517: UGUUUAAGCU GAUGAGGCCG AAAGGCCGAA AAGAAUCU 38 INFORMATION FOR SEQ ID NO:518: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:518: GAUUCUUUCU UAAACAC 17 INFORMATION FOR SEQ ID NO:519: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:519: GUGUUUAACU GAUGAGGCCG AAAGGCCGAA AAAGAAUC 38 INFORMATION FOR SEQ ID NO:520: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:520: UUCUUUCUUA AACACUU 17 INFORMATION FOR SEQ ID NO:521: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:521: AAGUGUUUCU GAUGAGGCCG AAAGGCCGAA AGAAAGAA 38 INFORMATION FOR SEQ ID NO:522: S" SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:522: UCUUUCUUAA ACACUUC 17 INFORMATION FOR SEQ ID NO:523: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:523: GAAGUGUUCU GAUGAGGCCG AAAGGCCGAA AAGAAAGA 38 INFORMATION FOR SEQ ID NO:524: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:524: UAAACACUUC CAGUAAC 17 INFORMATION FOR SEQ ID NO:525: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:525: GUUACUGGCU GAUGAGGCCG AAAGGCCGAA AGUGUUUA 38 INFORMATION FOR SEQ ID NO:526: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:526: AAACACUUCC AGUAACC 17 INFORMATION FOR SEQ ID NO:527: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:527: GGUUACUGCU GAUGAGGCCG AAAGGCCGAA AAGUGUUU 38 INFORMATION FOR SEQ ID NO:528: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:528: CUUCCAGUAA CCAUGAA 17 INFORMATION FOR SEQ ID NO:529: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:529: UUCAUGGUCU GAUGAGGCCG AAAGGCCGAA ACUGGAAG 38 INFORMATION FOR SEQ ID NO:530: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:530: UGAAAACUCA GACUUGG 17 INFORMATION FOR SEQ ID NO:531: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single I 7 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:531: CCAAGUCUCU GAUGAGGCCG AAAGGCCGAA AGUUUUCA 38 INFORMATION FOR SEQ ID NO:532: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:532: CUCAGACUUG GAAAUGC 17 INFORMATION FOR SEQ ID NO:533: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:533: GCAUUUCCCU GAUGAGGCCG AAAGGCCGAA AGUCUGAG 38 INFORMATION FOR SEQ ID NO:534: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:534: AAAUGCCUUC UUUAACU 17 INFORMATION FOR SEQ ID NO:535: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:535: AGUUAAAGCU GAUGAGGCCG AAAGGCCGAA AGGCAUUU 38 INFORMATION FOR SEQ ID NO:536: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:536: AAUGCCUUCU UUAACUU 17 INFORMATION FOR SEQ ID NO:537: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs I'93 TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:537: AAGUUAAACU GAUGAGGCCG AAAGGCCGAA AAGGCAUU 38 INFORMATION FOR SEQ ID NO:538: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:538: UGCCUUCUUU AACUUCC 17 INFORMATION FOR SEQ ID NO:539: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:539: GGAAGUUACU GAUGAGGCCG AAAGGCCGAA AGAAGGCA 38 INFORMATION FOR SEQ ID NO:540: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:540: oo GCCUUCUUUA ACUUCCA 17 INFORMATION FOR SEQ ID NO:541: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:541: UGGAAGUUCU GAUGAGGCCG AAAGGCCGAA AAGAAGGC 38 INFORMATION FOR SEQ ID NO:542: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:542: CCUUCUUUAA CUUCCAC 17 INFORMATION FOR SEQ ID NO:543: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:543: GUGGAAGUCU GAUGAGGCCG AAAGGCCGAA AAAGAAGG 38 INFORMATION FOR SEQ ID NO:544: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:544: CUUUAACUUC CACCCCC 17 INFORMATION FOR SEQ ID NO:545: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:545: GGGGGUGGCU GAUGAGGCCG AAAGGCCGAA AGUUAAAG 38 INFORMATION FOR SEQ ID NO:546: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:546: UUUAACUUCC ACCCCCC 17 INFORMATION FOR SEQ ID NO:547: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:547: GGGGGGUGCU GAUGAGGCCG AAAGGCCGAA AAGUUAAA 38 INFORMATION FOR SEQ ID NO:548: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:548: ACCCCCCUCA UUGGUCA 17 200 INFORMATION FOR SEQ ID NO:549: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:549: UGACCAAUCU GAUGAGGCCG AAAGGCCGAA AGGGGGGU 38 INFORMATION FOR SEQ ID NO:550: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:550: CCCCUCAUUG GUCACAA 17 INFORMATION FOR SEQ ID NO:551: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:551: UUGUGACCCU GAUGAGGCCG AAAGGCCGAA AUGAGGGG 38 INFORMATION FOR SEQ ID NO:552: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:552: S UCAUUGGUCA CAAAUUG 17 INFORMATION FOR SEQ ID NO:553: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:553: CAAUUUGUCU GAUGAGGCCG AAAGGCCGAA ACCAAUGA 38 INFORMATION FOR SEQ ID NO:554: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:554: UCACAAAUUG ACUGUUA 17 INFORMATION FOR SEQ ID NO:555: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:555: UAACAGUCCU GAUGAGGCCG AAAGGCCGAA AUUUGUGA 38 INFORMATION FOR SEQ ID NO:556: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:556: UUGACUGUUA CAACACC 17 INFORMATION FOR SEQ ID NO:557: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:557: GGUGUUGUCU GAUGAGGCCG AAAGGCCGAA ACAGUCAA 38 INFORMATION FOR SEQ ID NO:558: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:558: UGACUGUUAC AACACCA 17 INFORMATION FOR SEQ ID NO:559: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:559: UGGUGUUGCU GAUGAGGCCG AAAGGCCGAA AACAGUCA 38 INFORMATION FOR SEQ ID NO:560: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 202 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:560: AACACCAUUU CAUAGAG 17 INFORMATION FOR SEQ ID NO:561: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:561: CUCUAUGACU GAUGAGGCCG AAAGGCCGAA AUGGUGUU 38 INFORMATION FOR SEQ ID NO:562: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:562: ACACCAUUUC AUAGAGA 17 INFORMATION FOR SEQ ID NO:563: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:563: UCUCUAUGCU GAUGAGGCCG AAAGGCCGAA AAUGGUGU 38 INFORMATION FOR SEQ ID NO:564: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:564: CACCAUUUCA UAGAGAC 17 INFORMATION FOR SEQ ID NO:565: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:565: GUCUCUAUCU GAUGAGGCCG AAAGGCCGAA AAAUGGUG 38 INFORMATION FOR SEQ ID NO:566: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:566: CAUUUCAUAG AGACCAG 17 INFORMATION FOR SEQ ID NO:567: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:567: CUGGUCUCCU GAUGAGGCCG AAAGGCCGAA AUGAAAUG 38 INFORMATION FOR SEQ ID NO:568: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:568: S UGAAAACUCA AAAGGAA 17 INFORMATION FOR SEQ ID NO:569: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:569: S UUCCUUUUCU GAUGAGGCCG AAAGGCCGAA AGUUUUCA 38 INFORMATION FOR SEQ ID NO:570: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:570: AGGAAAAUAC UGUUUUU 17 INFORMATION FOR SEQ ID NO:571: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:571: AAAAACAGCU GAUGAGGCCG AAAGGCCGAA AUUUUCCU 38 INFORMATION FOR SEQ ID NO:572: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:572: AAUACUGUUU UUAGAAC 17 INFORMATION FOR SEQ ID NO:573: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:573: GUUCUAAACU GAUGAGGCCG AAAGGCCGAA ACAGUAUU 38 INFORMATION FOR SEQ ID NO:574: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:574: AUACUGUUUU UAGAACC 17 INFORMATION FOR SEQ ID NO:575: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:575: GGUUCUAACU GAUGAGGCCG AAAGGCCGAA AACAGUAU 38 INFORMATION FOR SEQ ID NO:576: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:576: UACUGUUUUU AGAACCC 17 INFORMATION FOR SEQ ID NO:577: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:577: GGGUUCUACU GAUGAGGCCG AAAGGCCGAA AAACAGUA 38 INFORMATION FOR SEQ ID NO:578: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:578: ACUGUUUUUA GAACCCC 17 INFORMATION FOR SEQ ID NO:579: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:579: GGGGUUCUCU GAUGAGGCCG AAAGGCCGAA AAAACAGU 38 INFORMATION FOR SEQ ID NO:580: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:580: CUGUUUUUAG AACCCCA 17 INFORMATION FOR SEQ ID NO:581: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:581: UGGGGUUCCU GAUGAGGCCG AAAGGCCGAA AAAAACAG 38 INFORMATION FOR SEQ ID N0:582: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:582: CCCCAGCUAU CAAAAGG 17 INFORMATION FOR SEQ ID NO:583: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:583: CCUUUUGACU GAUGAGGCCG AAAGGCCGAA AGCUGGGG 7n INFORMATION FOR SEQ ID NO:584: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:584: CCAGCUAUCA AAAGGUC 17 INFORMATION FOR SEQ ID NO:585: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:585: GACCUUUUCU GAUGAGGCCG AAAGGCCGAA AUAGCUGG 38 INFORMATION FOR SEQ ID NO:586: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:586: CAAAAGGUCA AUCUUAG 17 INFORMATION FOR SEQ ID NO:587: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:587: CUAAGAUUCU GAUGAGGCCG AAAGGCCGAA ACCUUUUG 38 INFORMATION FOR SEQ ID NO:588: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:588: AGGUCAAUCU UAGAAAG 17 INFORMATION FOR SEQ ID NO:589: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:589: Z07 O CUUUCUAACU GAUGAGGCCG AAAGGCCGAA AUUGACCU 38 INFORMATION FOR SEQ ID NO:590: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:590: GUCAAUCUUA GAAAGCU 17 INFORMATION FOR SEQ ID NO:591: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:591: AGCUUUCUCU GAUGAGGCCG AAAGGCCGAA AGAUUGAC 38 INFORMATION FOR SEQ ID NO:592: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:592: UCAAUCUUAG AAAGCUC 17 INFORMATION FOR SEQ ID NO:593: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:593: GAGCUUUCCU GAUGAGGCCG AAAGGCCGAA AAGAUUGA 38 INFORMATION FOR SEQ ID NO:594: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:594: AAAGCUCUCC AAGAACU 17 INFORMATION FOR SEQ ID NO:595: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:595: AGUUCUUGCU GAUGAGGCCG AAAGGCCGAA AGAGCUUU 38 INFORMATION FOR SEQ ID NO:596: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:596: CAAGAACUCC UACACCA 17 INFORMATION FOR SEQ ID NO:597: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:597: UGGUGUAGCU GAUGAGGCCG AAAGGCCGAA AGUUCUUG 38 INFORMATION FOR SEQ ID NO:598: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:598: GAACUCCUAC ACCAUUC 17 INFORMATION FOR SEQ ID NO:599: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear

C

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:599: GAAUGGUGCU GAUGAGGCCG AAAGGCCGAA AGGAGUUC 38 INFORMATION FOR SEQ ID NO:600: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:600: UACACCAUUC AAACAUG 17 INFORMATION FOR SEQ ID NO:601: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:601: CAUGUUUGCU GAUGAGGCCG AAAGGCCGAA AUGGUGUA 38 INFORMATION FOR SEQ ID NO:602: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:602: ACACCAUUCA AACAUGC 17 INFORMATION FOR SEQ ID NO:603: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:603: S* GCAUGUUUCU GAUGAGGCCG AAAGGCCGAA AAUGGUGU 38 S* INFORMATION FOR SEQ ID NO:604: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:604: CAUGCACUUG CAGCUCA 17 INFORMATION FOR SEQ ID NO:605: *9 *0 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:605: UGAGCUGCCU GAUGAGGCCG AAAGGCCGAA AGUGCAUG 38 INFORMATION FOR SEQ ID NO:606: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:606: UUGCAGCUCA AGAAAUU 17 INFORMATION FOR SEQ ID NO:607: SEQUENCE CHARACTERISTICS:

I

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:607: AAUUUCUUCU GAUGAGGCCG AAAGGCCGAA AGCUGCAA 38 INFORMATION FOR SEQ ID NO:608: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:608: CAAGAAAUUA AAUACGG 17 INFORMATION FOR SEQ ID NO:609: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:609: CCGUAUUUCU GAUGAGGCCG AAAGGCCGAA AUUUCUUG 38 INFORMATION FOR SEQ ID NO:610: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:610: AAGAAAUUAA AUACGGU 17 INFORMATION FOR SEQ ID NO:611: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:611: ACCGUAUUCU GAUGAGGCCG AAAGGCCGAA AAUUUCUU 38 INFORMATION FOR SEQ ID NO:612: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:612: AAUACGGUCC CCUGAAG 17 INFORMATION FOR SEQ ID NO:613: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:613: CUUCAGGGCU GAUGAGGCCG AAAGGCCGAA ACCGUAUU 38 INFORMATION FOR SEQ ID NO:614: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:614: AAGAUGCUAC CUCAGAC 17 INFORMATION FOR SEQ ID NO:615: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:615: GUCUGAGGCU GAUGAGGCCG AAAGGCCGAA AGCAUCUU 38 INFORMATION FOR SEQ ID NO:616: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear o .o (xi) SEQUENCE DESCRIPTION: SEQ ID NO:616: UGCUACCUCA GACACCC 17 INFORMATION FOR SEQ ID NO:617: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:617: GGGUGUCUCU GAUGAGGCCG AAAGGCCGAA AGGUAGCA 38 INFORMATION FOR SEQ ID NO:618: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:618: GACACCCUCU CAUCUAG i7 212 INFORMATION FOR SEQ ID NO:619: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:619: CUAGAUGACU GAUGAGGCCG AAAGGCCGAA AGGGUGUC 38 INFORMATION FOR SEQ ID NO:620: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:620: CACCCUCUCA UCUAGUA 17 INFORMATION FOR SEQ ID NO:621: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:621: S UACUAGAUCU GAUGAGGCCG AAAGGCCGAA AGAGGGUG 38 INFORMATION FOR SEQ ID NO:622: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear O* 9 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:622: CCUCUCAUCU AGUAGAA 17 INFORMATION FOR SEQ ID NO:623: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:623: UUCUACUACU GAUGAGGCCG AAAGGCCGAA AUGAGAGG 38 INFORMATION FOR SEQ ID NO:624: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:624: 213 UCUCAUCUAG UAGAAGA 17 INFORMATION FOR SEQ ID NO:625: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:625: UCUUCUACCU GAUGAGGCCG AAAGGCCGAA AGAUGAGA 38 INFORMATION FOR SEQ ID NO:626: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:626: CAUCUAGUAG AAGAUCU 17 INFORMATION FOR SEQ ID NO:627: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:627:

*S

AGAUCUUCCU GAUGAGGCCG AAAGGCCGAA ACUAGAUG 38 INFORMATION FOR SEQ ID NO:628: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:628: UAGAAGAUCU GCAGGAU 17 INFORMATION FOR SEQ ID NO:629: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:629: AUCCUGCACU GAUGAGGCCG AAAGGCCGAA AUCUUCUA 38 INFORMATION FOR SEQ ID NO:630: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 2I1- 0 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:630: GAUGUGAUCA AACAGGA 17 INFORMATION FOR SEQ ID NO:631: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:631: UCCUGUUUCU GAUGAGGCCG AAAGGCCGAA AUCACAUC 38 INFORMATION FOR SEQ ID NO:632: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:632: S: ACAGGAAUCU GAUGAAU 17 INFORMATION FOR SEQ ID NO:633: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:633: AUUCAUCACU GAUGAGGCCG AAAGGCCGAA AUUCCUGU 38 INFORMATION FOR SEQ ID NO:634: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:634: UGAUGAAUCU GGAAUUG 17 INFORMATION FOR SEQ ID NO:635: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:635: CAAUUCCACU GAUGAGGCCG AAAGGCCGAA AUUCAUCA 38 INFORMATION FOR SEQ ID NO:636: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:636: UCUGGAAUUG UUGCUGA 17 INFORMATION FOR SEQ ID NO:637: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:637: UCAGCAACCU GAUGAGGCCG AAAGGCCGAA AUUCCAGA 38 INFORMATION FOR SEQ ID NO:638: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear i (xi) SEQUENCE DESCRIPTION: SEQ ID NO:638: SGGAAUUGUUG CUGAGUU 17 INFORMATION FOR SEQ ID NO:639: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:639: AACUCAGCCU GAUGAGGCCG AAAGGCCGAA ACAAUUCC 38 INFORMATION FOR SEQ ID NO:640: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:640: UGCUGAGUUU CAAGAAA 17 INFORMATION FOR SEQ ID NO:641: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:641: UUUCUUGACU GAUGAGGCCG AAAGGCCGAA ACUCAGCA 38 INFORMATION FOR SEQ ID NO:642: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs 21G TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:642: GCUGAGUUUC AAGAAAA 17 INFORMATION FOR SEQ ID NO:643: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:643: UUUUCUUGCU GAUGAGGCCG AAAGGCCGAA AACUCAGC 38 INFORMATION FOR SEQ ID NO:644: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:644: ACCACCCUUA CUGAAGA 17 INFORMATION FOR SEQ ID NO:645: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:645: UCUUCAGUCU GAUGAGGCCG AAAGGCCGAA AGGGUGGU 38 INFORMATION FOR SEQ ID NO:646: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:646: CCACCCUUAC UGAAGAA 17 INFORMATION FOR SEQ ID NO:647: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:647: UUCUUCAGCU GAUGAGGCCG AAAGGCCGAA AAGGGUGG 38 INFORMATION FOR SEQ ID NO:648: Zi7 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:648: AAGAAAAUCA AACAAGA 17 INFORMATION FOR SEQ ID NO:649: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:649: UCUUGUUUCU GAUGAGGCCG AAAGGCCGAA AUUUUCUU 38 INFORMATION FOR SEQ ID NO:650: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear *f (xi) SEQUENCE DESCRIPTION: SEQ ID NO:650: GGUGGAAUCU CCAACUG 1 7 INFORMATION FOR SEQ ID NO:651: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:651: CAGUUGGACU GAUGAGGCCG AAAGGCCGAA AUUCCACC 38 INFORMATION FOR SEQ ID NO:652: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:652: UGGAAUCUCC AACUGAU 17 INFORMATION FOR SEQ ID NO:653: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:653: AUCAGUUGCU GAUGAGGCCG AAAGGCCGAA AGAUUCCA

'I

INFORMATION FOR SEQ ID NO:654: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:654: CAACUGAUAA AUCAGGA 17 INFORMATION FOR SEQ ID NO:655: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:655: UCCUGAUUCU GAUGAGGCCG AAAGGCCGAA AUCAGUUG 38 INFORMATION FOR SEQ ID NO:656: S* SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:656: UGAUAAAUCA GGAAACU 17

S

INFORMATION FOR SEQ ID NO:657: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:657: AGUUUCCUCU GAUGAGGCCG AAAGGCCGAA AUUUAUCA 38 INFORMATION FOR SEQ ID NO:658: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:658: AGGAAACUUC UUCUGCU 17 INFORMATION FOR SEQ ID NO:659: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:659: 2,01 AGCAGAAGCU GAUGAGGCCG AAAGGCCGAA AGUUUCCU 38 INFORMATION FOR SEQ ID NO:660: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:660: GGAAACUUCU UCUGCUC 17 INFORMATION FOR SEQ ID NO:661: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:661: GAGCAGAACU GAUGAGGCCG AAAGGCCGAA AAGUUUCC 38 *9 INFORMATION FOR SEQ ID NO:662: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 9 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:662: 9 9 AAACUUCUUC UGCUCAC 17 INFORMATION FOR SEQ ID NO:663: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:663: GUGAGCAGCU GAUGAGGCCG AAAGGCCGAA AGAAGUUU 38 INFORMATION FOR SEQ ID NO:664: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:664: AACUUCUUCU GCUCACA 17 INFORMATION FOR SEQ ID NO:665: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 220 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:665: UGUGAGCACU GAUGAGGCCG AAAGGCCGAA AAGAAGUU 38 INFORMATION FOR SEQ ID NO:666: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:666: CUUCUGCUCA CACCACU 17 INFORMATION FOR SEQ ID NO:667: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:667: AGUGGUGUCU GAUGAGGCCG AAAGGCCGAA AGCAGAAG 38 INFORMATION FOR SEQ ID NO:668: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:668: GGGACAGUCU GAAUACC 17 INFORMATION FOR SEQ ID NO:669: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:669: GGUAUUCACU GAUGAGGCCG AAAGGCCGAA ACUGUCCC 38 INFORMATION FOR SEQ ID NO:670: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:670: GUCUGAAUAC CCAACUG 17 INFORMATION FOR SEQ ID NO:671: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid 2.2-1 STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:671: CAGUUGGGCU GAUGAGGCCG AAAGGCCGAA AUUCAGAC 38 INFORMATION FOR SEQ ID NO:672: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:672: CCAACUGUUC ACGCAGA 17 INFORMATION FOR SEQ ID NO:673: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:673: UCUGCGUGCU GAUGAGGCCG AAAGGCCGAA ACAGUUGG 38 INFORMATION FOR SEQ ID NO:674: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:674: CAACUGUUCA CGCAGAC 17 INFORMATION FOR SEQ ID NO:675: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:675: GUCUGCGUCU GAUGAGGCCG AAAGGCCGAA AACAGUUG 38 INFORMATION FOR SEQ ID NO:676: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:676: GCAGACCUCG CCUGUGG 17 INFORMATION FOR SEQ ID NO:677: 222 0 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:677: CCACAGGCCU GAUGAGGCCG AAAGGCCGAA AGGUCUGC 38 INFORMATION FOR SEQ ID NO:678: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:678: CACCGAAUAU UCUUACA 17 INFORMATION FOR SEQ ID NO:679: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:679: UGUAAGAACU GAUGAGGCCG AAAGGCCGAA AUUCGGUG 38 INFORMATION FOR SEQ ID NO:680: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:680: CCGAAUAUUC UUACAAG 17 INFORMATION FOR SEQ ID NO:681: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:681: CUUGUAAGCU GAUGAGGCCG AAAGGCCGAA AUAUUCGG 38 INFORMATION FOR SEQ ID NO:682: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:682: CGAAUAUUCU UACAAGC 17 INFORMATION FOR SEQ ID NO:683: 223 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:683: GCUUGUAACU GAUGAGGCCG AAAGGCCGAA AAUAUUCG 38 INFORMATION FOR SEQ ID NO:684: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:684: AAUAUUCUUA CAAGCUC 17 INFORMATION FOR SEQ ID NO:685: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:685: GAGCUUGUCU GAUGAGGCCG AAAGGCCGAA AGAAUAUU 38 INFORMATION FOR SEQ ID NO:686: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:686: AUAUUCUUAC AAGCUCC 17 INFORMATION FOR SEQ ID NO:687: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:687: GGAGCUUGCU GAUGAGGCCG AAAGGCCGAA AAGAAUAU 38 INFORMATION FOR SEQ ID NO:688: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:688: UACAAGCUCC GUUUUAA 17 Z24 INFORMATION FOR SEQ ID NO:689: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:689: UUAAAACGCU GAUGAGGCCG AAAGGCCGAA AGCUUGUA 38 INFORMATION FOR SEQ ID NO:690: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:690: AGCUCCGUUU UAAUGGC 17 INFORMATION FOR SEQ ID NO:691: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:691: S GCCAUUAACU GAUGAGGCCG AAAGGCCGAA ACGGAGCU 38 INFORMATION FOR SEQ ID NO:692: *00 SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:692: GCUCCGUUUU AAUGGCA 17 INFORMATION FOR SEQ ID NO:693: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:693: UGCCAUUACU GAUGAGGCCG AAAGGCCGAA AACGGAGC 38 INFORMATION FOR SEQ ID NO:694: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:694: 2-2-5 CUCCGUUUUA AUGGCAC 17 INFORMATION FOR SEQ ID NO:695: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:695: GUGCCAUUCU GAUGAGGCCG AAAGGCCGAA AAACGGAG 38 INFORMATION FOR SEQ ID NO:696: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:696: UCCGUUUUAA UGGCACC INFORMATION FOR SEQ ID NO:697: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:697: GGUGCCAUCU GAUGAGGCCG AAAGGCCGAA AAAACGGA 38 INFORMATION FOR SEQ ID NO:698: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:698: ACCAGCAUCA GAAGAUG 17 INFORMATION FOR SEQ ID NO:699: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:699: CAUCUUCUCU GAUGAGGCCG AAAGGCCGAA AUGCUGGU 38 INFORMATION FOR SEQ ID NO:700: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear Z2G S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:700: GACAAUGUUC UCAAAGC 17 INFORMATION FOR SEQ ID NO:701: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:701: GCUUUGAGCU GAUGAGGCCG AAAGGCCGAA ACAUUGUC 38 INFORMATION FOR SEQ ID NO:702: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:702: ACAAUGUUCU CAAAGCA 17 INFORMATION FOR SEQ ID NO:703: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear

S

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:703: UGCUUUGACU GAUGAGGCCG AAAGGCCGAA AACAUUGU 38 INFORMATION FOR SEQ ID NO:704: SEQUENCE CHARACTERISTICS: oDD LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:704: AAUGUUCUCA AAGCAUU 17 INFORMATION FOR SEQ ID NO:705: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:705: AAUGCUUUCU GAUGAGGCCG AAAGGCCGAA AGAACAUU 38 INFORMATION FOR SEQ ID NO:706: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single 227 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:706: CAAAGCAUUU ACAGUAC 17 INFORMATION FOR SEQ ID NO:707: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:707: GUACUGUACU GAUGAGGCCG AAAGGCCGAA AUGCUUUG 38 INFORMATION FOR SEQ ID NO:708: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:708: S* AAAGCAUUUA CAGUACC 17 INFORMATION FOR SEQ ID NO:709: SEQUENCE CHARACTERISTICS: Sf.. LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:709: GGUACUGUCU GAUGAGGCCG AAAGGCCGAA AAUGCUUU 38 INFORMATION FOR SEQ ID NO:710: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:710: AAGCAUUUAC AGUACCU 17 INFORMATION FOR SEQ ID NO:711: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:711: AGGUACUGCU GAUGAGGCCG AAAGGCCGAA AAAUGCUU 38 INFORMATION FOR SEQ ID NO:712: SEQUENCE CHARACTERISTICS: 229 LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:712: UUUACAGUAC CUAAAAA 17 INFORMATION FOR SEQ ID NO:713: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:713: S UUUUUAGGCU GAUGAGGCCG AAAGGCCGAA ACUGUAAA 38 INFORMATION FOR SEQ ID NO:714: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs o TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:714: CAGUACCUAA AAACAGG 17 INFORMATION FOR SEQ ID NO:715: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:715: CCUGUUUUCU GAUGAGGCCG AAAGGCCGAA AGGUACUG 38 INFORMATION FOR SEQ ID NO:716: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:716: AAACAGGUCC CUGGCGA 17 INFORMATION FOR SEQ ID NO:717: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:717: UCGCCAGGCU GAUGAGGCCG AAAGGCCGAA ACCUGUUU 38 22C INFORMATION FOR SEQ ID NO:718: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:718: GAGCCCCUUG CAGCCUU 17 INFORMATION FOR SEQ ID NO:719: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:719: AAGGCUGCCU GAUGAGGCCG AAAGGCCGAA AGGGGCUC 38 INFORMATION FOR SEQ ID NO:720: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:720: UGCAGCCUUG UAGCAGU 17 INFORMATION FOR SEQ ID NO:721: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:721: ACUGCUACCU GAUGAGGCCG AAAGGCCGAA AGGCUGCA 38 INFORMATION FOR SEQ ID NO:722: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:722: AGCCUUGUAG CAGUACC 17 INFORMATION FOR SEQ ID NO:723: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:723: GGUACUGCCU GAUGAGGCCG AAAGGCCGAA ACAAGGCU 38 23) INFORMATION FOR SEQ ID NO:724: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:724: GUAGCAGUAC CUGGGAA 17 INFORMATION FOR SEQ ID NO:725: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:725: UUCCCAGGCU GAUGAGGCCG AAAGGCCGAA ACUGCUAC 38 INFORMATION FOR SEQ ID NO:726: S• SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:726: ACCUGCAUCC UGUGGAA 17 INFORMATION FOR SEQ ID NO:727: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:727: UUCCACAGCU GAUGAGGCCG AAAGGCCGAA AUGCAGGU 38 INFORMATION FOR SEQ ID NO:728: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:728: GAUGACAUCU UCCAGUC 17 INFORMATION FOR SEQ ID NO:729: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:729: 231 GACUGGAACU GAUGAGGCCG AAAGGCCGAA AUGUCAUC 38 INFORMATION FOR SEQ ID NO:730: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:730: UGACAUCUUC CAGUCAA 17 INFORMATION FOR SEQ ID NO:731: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:731: UUGACUGGCU GAUGAGGCCG AAAGGCCGAA AGAUGUCA 38 INFORMATION FOR SEQ ID NO:732: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:732: GACAUCUUCC AGUCAAG 17 INFORMATION FOR SEQ ID NO:733: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:733: CUUGACUGCU GAUGAGGCCG AAAGGCCGAA AAGAUGUC 38 INFORMATION FOR SEQ ID NO:734: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:734: CUUCCAGUCA AGCUCGU 17 INFORMATION FOR SEQ ID NO:735: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 252 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:735: ACGAGCUUCU GAUGAGGCCG AAAGGCCGAA ACUGGAAG 38 INFORMATION FOR SEQ ID NO:736: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:736: GUCAAGCUCG UAAAUAC 17 INFORMATION FOR SEQ ID NO:737: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:737: GUAUUUACCU GAUGAGGCCG AAAGGCCGAA AGCUUGAC 38 INFORMATION FOR SEQ ID NO:738: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:738: AAGCUCGUAA AUACGUG 17 INFORMATION FOR SEQ ID NO:739: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:739: CACGUAUUCU GAUGAGGCCG AAAGGCCGAA ACGAGCUU 38 INFORMATION FOR SEQ ID NO:740: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:740: UCGUAAAUAC GUGAAUG 17 INFORMATION FOR SEQ ID NO:741: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 233 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:741: CAUUCACGCU GAUGAGGCCG AAAGGCCGAA AUUUACGA 38 INFORMATION FOR SEQ ID NO:742: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:742: GAAUGCAUUC UCAGCCC 17 INFORMATION FOR SEQ ID NO:743: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:743: GGGCUGAGCU GAUGAGGCCG AAAGGCCGAA AUGCAUUC 38 INFORMATION FOR SEQ ID NO:744: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:744: SAAUGCAUUCU CAGCCCG 17 INFORMATION FOR SEQ ID NO:745: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:745: CGGGCUGACU GAUGAGGCCG AAAGGCCGAA AAUGCAUU 38 INFORMATION FOR SEQ ID NO:746: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:746: UGCAUUCUCA GCCCGGA 17 INFORMATION FOR SEQ ID NO:747: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:747: UCCGGGCUCU GAUGAGGCCG AAAGGCCGAA AGAAUGCA 38 INFORMATION FOR SEQ ID NO:748: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:748: ACGCUGGUCA UGUGAGA 17 INFORMATION FOR SEQ ID NO:749: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:749: UCUCACAUCU GAUGAGGCCG AAAGGCCGAA ACCAGCGU 38 INFORMATION FOR SEQ ID NO:750: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:750: UGAGACAUUU CCAGAAA 17 INFORMATION FOR SEQ ID NO:751: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:751: UUUCUGGACU GAUGAGGCCG AAAGGCCGAA AUGUCUCA 38 INFORMATION FOR SEQ ID NO:752: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:752: GAGACAUUUC CAGAAAA 17 INFORMATION FOR SEQ ID NO:753: 23z5 0 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:753: UUUUCUGGCU GAUGAGGCCG AAAGGCCGAA AAUGUCUC 38 INFORMATION FOR SEQ ID NO:754: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:754: AGACAUUUCC AGAAAAG 17 INFORMATION FOR SEQ ID NO:755: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:755: CUUUUCUGCU GAUGAGGCCG AAAGGCCGAA AAAUGUCU 38 INFORMATION FOR SEQ ID NO:756: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:756: AAAAGCAUUA UGGUUUU 17 INFORMATION FOR SEQ ID NO:757: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:757: AAAACCAUCU GAUGAGGCCG AAAGGCCGAA AUGCUUUU 38 INFORMATION FOR SEQ ID NO:758: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:758: AAAGCAUUAU GGUUUUC 23<4 INFORMATION FOR SEQ ID NO:759: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:759: GAAAACCACU GAUGAGGCCG AAAGGCCGAA AAUGCUUU 38 INFORMATION FOR SEQ ID NO:760: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:760: AUUAUGGUUU UCAGAAC 17 INFORMATION FOR SEQ ID NO:761: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:761: GUUCUGAACU GAUGAGGCCG AAAGGCCGAA ACCAUAAU 38 INFORMATION FOR SEQ ID NO:762: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:762: UUAUGGUUUU

CAGAACA

17 INFORMATION FOR SEQ ID NO:763: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:763: UGUUCUGACU GAUGAGGCCG AAAGGCCGAA AACCAUAA 38 INFORMATION FOR SEQ ID NO:764: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:764: Z37 UAUGGUUUUC AGAACAC 17 INFORMATION FOR SEQ ID NO:765: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:765: GUGUUCUGCU GAUGAGGCCG AAAGGCCGAA AAACCAUA 38 INFORMATION FOR SEQ ID NO:766: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:766: AUGGUUUUCA GAACACU 17 INFORMATION FOR SEQ ID NO:767: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S: STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:767: AGUGUUCUCU GAUGAGGCCG AAAGGCCGAA AAAACCAU 38 INFORMATION FOR SEQ ID NO:768: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:768: AGAACACUUC AAGUUGA 17 INFORMATION FOR SEQ ID NO:769: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:769: UCAACUUGCU GAUGAGGCCG AAAGGCCGAA AGUGUUCU 38 INFORMATION FOR SEQ ID NO:770: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:770: GAACACUUCA AGUUGAC 17 INFORMATION FOR SEQ ID NO:771: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:771: GUCAACUUCU GAUGAGGCCG AAAGGCCGAA AAGUGUUC 38 INFORMATION FOR SEQ ID NO:772: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:772: CUUCAAGUUG ACUUGGG 17 INFORMATION FOR SEQ ID NO:773: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:773: CCCAAGUCCU GAUGAGGCCG AAAGGCCGAA ACUUGAAG 38 INFORMATION FOR SEQ ID NO:774: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:774: AGUUGACUUG GGAUAUA 17 INFORMATION FOR SEQ ID NO:775: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:775: UAUAUCCCCU GAUGAGGCCG AAAGGCCGAA AGUCAACU 38 INFORMATION FOR SEQ ID NO:776: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid 1 23Z STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:776: CUUGGGAUAU AUCAUUC 17 INFORMATION FOR SEQ ID NO:777: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:777: GAAUGAUACU GAUGAGGCCG AAAGGCCGAA AUCCCAAG 38 INFORMATION FOR SEQ ID NO:778: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear 9 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:778: UGGGAUAUAU CAUUCCU 17 INFORMATION FOR SEQ ID NO:779: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:779: AGGAAUGACU GAUGAGGCCG AAAGGCCGAA AUAUCCCA 38 o INFORMATION FOR SEQ ID NO:780: SEQUENCE CHARACTERISTICS: S* LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:780: GGAUAUAUCA UUCCUCA 17 INFORMATION FOR SEQ ID NO:781: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:781: UGAGGAAUCU GAUGAGGCCG AAAGGCCGAA AUAUAUCC 38 INFORMATION FOR SEQ ID NO:782: 2 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:782: UAUAUCAUUC CUCAACA 17 INFORMATION FOR SEQ ID NO:783: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:783: UGUUGAGGCU GAUGAGGCCG AAAGGCCGAA AUGAUAUA 38 INFORMATION FOR SEQ ID NO:784: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:784: AUAUCAUUCC UCAACAU 17 INFORMATION FOR SEQ ID NO:785: S. SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear a (xi) SEQUENCE DESCRIPTION: SEQ ID NO:785: AUGUUGAGCU GAUGAGGCCG AAAGGCCGAA AAUGAUAU 38 INFORMATION FOR SEQ ID NO:786: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:786: UCAUUCCUCA ACAUGAA 17 INFORMATION FOR SEQ ID NO:787: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:787: UUCAUGUUCU GAUGAGGCCG AAAGGCCGAA AGGAAUGA 38 INFORMATION FOR SEQ ID NO:788: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:788: AUGAAACUUU UCAUGAA 17 INFORMATION FOR SEQ ID NO:789: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:789: UUCAUGAACU GAUGAGGCCG AAAGGCCGAA AGUUUCAU 38 INFORMATION FOR SEQ ID NO:790: 0* SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:790: UGAAACUUUU CAUGAAU 17 9* INFORMATION FOR SEQ ID NO:791: 9* 5 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:791:

S.

AUUCAUGACU GAUGAGGCCG AAAGGCCGAA AAGUUTUCA 38 38 INFORMATION FOR SEQ ID NO:792: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:792: GAAACUUUUC AUGAAUG 17 INFORMATION FOR SEQ ID NO:793: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:793: CAUUCAUGCU GAUGAGGCCG AAAGGCCGAA AAAGUUUC Z4-2 INFORMATION FOR SEQ ID NO:794: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:794: AAACUUUUCA UGAAUGG 17 INFORMATION FOR SEQ ID NO:795: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:795: .CCAUUCAUCU GAUGAGGCCG AAAGGCCGAA AAAAGUUU 38 INFORMATION FOR SEQ ID NO:796: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:796: AAGAACCUAU UUUUGUU 17 INFORMATION FOR SEQ ID NO:797: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:797: AACAAAAACU GAUGAGGCCG AAAGGCCGAA AGGUUCUU 38 INFORMATION FOR SEQ ID NO:798: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:798: GAACCUAUUU UUGUUGU 17 INFORMATION FOR SEQ ID NO:799: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:799: 2-4- 3 ACAACAAACU GAUGAGGCCG AAAGGCCGAA AUAGGUUC 38 INFORMATION FOR SEQ ID NO:800: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:800: AACCUAUUUU UGUUGUG 17 INFORMATION FOR SEQ ID NO:801: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:801: CACAACAACU GAUGAGGCCG AAAGGCCGAA AAUAGGUU 38 INFORMATION FOR SEQ ID NO:802: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear o (xi) SEQUENCE DESCRIPTION: SEQ ID NO:802: ACCUAUUUUU GUUGUGG 17 INFORMATION FOR SEQ ID NO:803: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:803: CCACAACACU GAUGAGGCCG AAAGGCCGAA AAAUAGGU 38 INFORMATION FOR SEQ ID NO:804: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:804: CCUAUUUUUG UUGUGGU 17 INFORMATION FOR SEQ ID NO:805: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 2-4 W(xi) SEQUENCE DESCRIPTION: SEQ ID NO:805: ACCACAACCU GAUGAGGCCG AAAGGCCGAA AAAAUAGG 38 INFORMATION FOR SEQ ID NO:806: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:806: AUUUUUGUUG UGGUACA 17 INFORMATION FOR SEQ ID NO:807: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:807: S* UGUACCACCU GAUGAGGCCG AAAGGCCGAA ACAAAAAU 38 INFORMATION FOR SEQ ID NO:808: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:808: GUUGUGGUAC AACAGUU 17 INFORMATION FOR SEQ ID NO:809: 9 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:809: AACUGUUGCU GAUGAGGCCG AAAGGCCGAA ACCACAAC 38 INFORMATION FOR SEQ ID NO:810: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:810: ACAACAGUUG AGAGCAG 17 INFORMATION FOR SEQ ID NO:811: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 240 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:811: CUGCUCUCCU GAUGAGGCCG AAAGGCCGAA ACUGUUGU 38 INFORMATION FOR SEQ ID NO:812: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:812: AAGUGCAUUU AGUUGAA 17 INFORMATION FOR SEQ ID NO:813: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:813: UUCAACUACU GAUGAGGCCG AAAGGCCGAA AUGCACUU 38 INFORMATION FOR SEQ ID NO:814: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:814: AGUGCAUUUA GUUGAAU 17 INFORMATION FOR SEQ ID NO:815: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:815: AUUCAACUCU GAUGAGGCCG AAAGGCCGAA AAUGCACU 38 INFORMATION FOR SEQ ID NO:816: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:816: GUGCAUUUAG UUGAAUG 17 INFORMATION FOR SEQ ID NO:817: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:817: CAUUCAACCU GAUGAGGCCG AAAGGCCGAA AAAUGCAC 38 INFORMATION FOR SEQ ID NO:818: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:818: CAUUUAGUUG AAUGAAG 17 INFORMATION FOR SEQ ID NO:819: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 0/ (xi) SEQUENCE DESCRIPTION: SEQ ID NO:819: CUUCAUUCCU GAUGAGGCCG AAAGGCCGAA ACUAAAUG 38 INFORMATION FOR SEQ ID NO:820: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:820: AAUGAAGUCU UCUUGGA 17 INFORMATION FOR SEQ ID NO:821: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:821: UCCAAGAACU GAUGAGGCCG AAAGGCCGAA ACUUCAUU 38 INFORMATION FOR SEQ ID N0:822: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:822: UGAAGUCUUC UUGGAUU 24-7 INFORMATION FOR SEQ ID NO:823: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:823: AAUCCAAGCU GAUGAGGCCG AAAGGCCGAA AGACUUCA 38 INFORMATION FOR SEQ ID NO:824: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:824: GAAGUCUUCU UGGAUUU 17 INFORMATION FOR SEQ ID NO:825: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:825: AAAUCCAACU GAUGAGGCCG AAAGGCCGAA AAGACUUC 38 INFORMATION FOR SEQ ID NO:826: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:826: AGUCUUCUUG GAUUUCA 17 INFORMATION FOR SEQ ID NO:827: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:827: UGAAAUCCCU GAUGAGGCCG AAAGGCCGAA AGAAGACU 38 INFORMATION FOR SEQ ID NO:828: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:828: UCUUGGAUUU CACCCAA INFORMATION FOR SEQ ID NO:829: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:829: UUGGGUGACU GAUGAGGCCG AAAGGCCGAA AUCCAAGA 38 INFORMATION FOR SEQ ID NO:830: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:830: CUUGGAUUUC ACCCAAC 17 INFORMATION FOR SEQ ID NO:831: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:831: S GUUGGGUGCU GAUGAGGCCG AAAGGCCGAA AAUCCAAG 38 INFORMATION FOR SEQ ID NO:832: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:832: UUGGAUUUCA CCCAACU 17 INFORMATION FOR SEQ ID NO:833: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:833: AGUUGGGUCU GAUGAGGCCG AAAGGCCGAA AAAUCCAA 38 INFORMATION FOR SEQ ID NO:834: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:834: 2 4+ S ACCCAACUAA AAGGAUU 17 INFORMATION FOR SEQ ID NO:835: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:835: AAUCCUUUCU GAUGAGGCCG AAAGGCCGAA AGUUGGGU 38 INFORMATION FOR SEQ ID NO:836: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:836: AAAAGGAUUU UUAAAAA 17 INFORMATION FOR SEQ ID NO:837: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:837: UUUUUAAACU GAUGAGGCCG AAAGGCCGAA AUCCUUUU 38 INFORMATION FOR SEQ ID NO:838: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:838: AAAGGAUUUU UAAAAAU 17 INFORMATION FOR SEQ ID NO:839: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:839: AUUUUUAACU GAUGAGGCCG AAAGGCCGAA AAUCCUUU 38 INFORMATION FOR SEQ ID NO:840: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear

ZSO

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:840: AAGGAUUUUU AAAAAUA 17 INFORMATION FOR SEQ ID NO:841: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:841: UAUUUUUACU GAUGAGGCCG AAAGGCCGAA AAAUCCUU 38 INFORMATION FOR SEQ ID NO:842: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:842: AGGAUUUUUA AAAAUAA 17 INFORMATION FOR SEQ ID NO:843: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:843: UUAUUUUUCU GAUGAGGCCG AAAGGCCGAA AAAAUCCU 38 S. INFORMATION FOR SEQ ID NO:844: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:844: UUAAAAAUAA AUAACAG 17 INFORMATION FOR SEQ ID NO:845: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:845: CUGUUAUUCU GAUGAGGCCG AAAGGCCGAA AUUUUUAA 38 INFORMATION FOR SEQ ID NO:846: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:846: AAAUAAAUAA CAGUCUU 17 INFORMATION FOR SEQ ID NO:847: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:847: AAGACUGUCU GAUGAGGCCG AAAGGCCGAA AUUUAUUU 38 INFORMATION FOR SEQ ID NO:848: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:848: SAUAACAGUCU UACCUAA 17 S(2) INFORMATION FOR SEQ ID NO:849: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:849: JUUAGGUAACU GAUGAGGCCG AAAGGCCGAA ACUGUUAU 38 INFORMATION FOR SEQ ID NO:850: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:850: AACAGUCUUA CCUAAAU 17 INFORMATION FOR SEQ ID NO:851: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:851: AUUUAGGUCU GAUGAGGCCG AAAGGCCGAA AGACUGUU 38 INFORMATION FOR SEQ ID NO:852: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs Z52 TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:852: ACAGUCUUAC CUAAAUU 17 INFORMATION FOR SEQ ID NO:853: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:853: AAUUUAGGCU GAUGAGGCCG AAAGGCCGAA AAGACUGU 38 INFORMATION FOR SEQ ID NO:854: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs 999* TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:854: UCUUACCUAA AUUAUUA 17 INFORMATION FOR SEQ ID NO:855: 9.

S

SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:855: UAAUAAUUCU GAUGAGGCCG AAAGGCCGAA AGGUAAGA 38 INFORMATION FOR SEQ ID NO:856: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:856: ACCUAAAUUA UUAGGUA 17 INFORMATION FOR SEQ ID NO:857: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:857: UACCUAAUCU GAUGAGGCCG AAAGGCCGAA AUUUAGGU 38 INFORMATION FOR SEQ ID NO:858: 253 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:858: CCUAAAUUAU UAGGUAA 17 INFORMATION FOR SEQ ID NO:859: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:859: UUACCUAACU GAUGAGGCCG AAAGGCCGAA AAUUUAGG 38 INFORMATION FOR SEQ ID NO:860: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:860: UAAAUUAUUA GGUAAUG 17 INFORMATION FOR SEQ ID NO:861: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:861: CAUUACCUCU GAUGAGGCCG AAAGGCCGAA AUAAUUUA 38 INFORMATION FOR SEQ ID N0:862: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:862: AAAUUAUUAG GUAAUGA 17 INFORMATION FOR SEQ ID NO:863: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:863: UCAUUACCCU GAUGAGGCCG AAAGGCCGAA AAUAAUUU 38 254 INFORMATION FOR SEQ ID NO:864: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:864: UAUUAGGUAA UGAAUUG 17 INFORMATION FOR SEQ ID NO:865: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:865: CAAUUCAUCU GAUGAGGCCG AAAGGCCGAA ACCUAAUA 38 INFORMATION FOR SEQ ID NO:866: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:866: UAAUGAAUUG UAGCCAG 17 INFORMATION FOR SEQ ID NO:867: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:867: CUGGCUACCU GAUGAGGCCG AAAGGCCGAA AUUCAUUA 38 INFORMATION FOR SEQ ID NO:868: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:868: UGAAUUGUAG CCAGUUG 17 INFORMATION FOR SEQ ID NO:869: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:869: CAACUGGCCU GAUGAGGCCG AAAGGCCGAA ACAAUUCA 38 INFORMATION FOR SEQ ID NO:870: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:870: UAGCCAGUUG UUAAUAU 17 INFORMATION FOR SEQ ID NO:871: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:871: AUAUUAACCU GAUGAGGCCG AAAGGCCGAA ACUGGCUA 38 INFORMATION FOR SEQ ID NO:872: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:872: CCAGUUGUUA AUAUCUU 17 INFORMATION FOR SEQ ID NO:873: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear o* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:873: AAGAUAUUCU GAUGAGGCCG AAAGGCCGAA ACAACUGG 38 INFORMATION FOR SEQ ID NO:874: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:874: CAGUUGUUAA UAUCUUA 17 INFORMATION FOR SEQ ID NO:875: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 9 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:875: UAAGAUAUCU GAUGAGGCCG AAAGGCCGAA AACAACUG 38 INFORMATION FOR SEQ ID NO:876: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:876: UUGUUAAUAU CUUAAUG 17 INFORMATION FOR SEQ ID NO:877: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:877: CAUUAAGACU GAUGAGGCCG AAAGGCCGAA AUUAACAA 38 INFORMATION FOR SEQ ID NO:878: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:878: GUUAAUAUCU UAAUGCA 17 INFORMATION FOR SEQ ID NO:879: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:879: UGCAUUAACU GAUGAGGCCG AAAGGCCGAA AUAUUAAC 38 INFORMATION FOR SEQ ID NO:880: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:880: UAAUAUCUUA AUGCAGA 17 INFORMATION FOR SEQ ID NO:881: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:881: UCUGCAUUCU GAUGAGGCCG AAAGGCCGAA AGAUAUUA 38 INFORMATION FOR SEQ ID NO:882: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:882: AAUAUCUUAA UGCAGAU 17 INFORMATION FOR SEQ ID NO:883: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:883: AUCUGCAUCU GAUGAGGCCG AAAGGCCGAA AAGAUAUU 38 INFORMATION FOR SEQ ID NO:884: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:884: o AUGCAGAUUU UUUUAAA 17 INFORMATION FOR SEQ ID NO:885: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:885: UUUAAAAACU GAUGAGGCCG AAAGGCCGAA AUCUGCAU 38 INFORMATION FOR SEQ ID NO:886: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:886: UGCAGAUUUU UUUAAAA 17 INFORMATION FOR SEQ ID NO:887: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:887: UUUUAAAACU GAUGAGGCCG AAAGGCCGAA AAUCUGCA 38 INFORMATION FOR SEQ ID NO:888: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:888: GCAGAUUUUU UUAAAAA 17 INFORMATION FOR SEQ ID NO:889: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:889: UUUUUAAACU GAUGAGGCCG AAAGGCCGAA AAAUCUGC 38 INFORMATION FOR SEQ ID NO:890: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:890: CAGAUUUUUU UAAAAAA 17 INFORMATION FOR SEQ ID NO:891: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:891: UUUUUUAACU GAUGAGGCCG AAAGGCCGAA AAAAUCUG 38 INFORMATION FOR SEQ ID NO:892: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:892: AGAUUUUUU AAAAAAA 17 INFORMATION FOR SEQ ID NO:893: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:893: ULUUUUUUACU GAUGAGGCCG AAAGGCCGAA AAAAAUCU 38 INFORMATION FOR SEQ ID NO:894: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:894: GAUUUUUUUA AAAAAAA 17 INFORMATION FOR SEQ ID NO:895: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:895: UUUUUUUUCU GAUGAGGCCG AAAGGCCGAA AAAAAAUC 38 INFORMATION FOR SEQ ID NO:896: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:896: AUUUUUUUAA AAAAAAC 17 INFORMATION FOR SEQ ID NO:897: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:897: GUUUUUUCU GAUGAGGCCG AAAGGCCGAA AAAAAAAU 38 INFORMATION FOR SEQ ID NO:898: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:898: AAAAACAUAA AAUGAUU 17 INFORMATION FOR SEQ ID NO:899: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:899: AAUCAUUUCU GAUGAGGCCG AAAGGCCGAA AUGUUUUU 38 INFORMATION FOR SEQ ID NO:900: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:900: AAAAUGAUUU AUCUGUA 17 INFORMATION FOR SEQ ID NO:901: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:901: UACAGAUACU GAUGAGGCCG AAAGGCCGAA AUCAUUUU 38 INFORMATION FOR SEQ ID NO:902: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:902: AAAUGAUUUA UCUGUAU 17 INFORMATION FOR SEQ ID NO:903: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:903: AUACAGAUCU GAUGAGGCCG AAAGGCCGAA AAUCAUUU 38 INFORMATION FOR SEQ ID NO:904: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:904: AAUGAUUUAU CUGUAUU 17 INFORMATION FOR SEQ ID NO:905: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:905: AAUACAGACU GAUGAGGCCG AAAGGCCGAA AAAUCAUU 38 INFORMATION FOR SEQ ID NO:906: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:906: UGAUUUAUCU GUAUUUU 17 INFORMATION FOR SEQ ID NO:907: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:907: S AAAAUACACU GAUGAGGCCG AAAGGCCGAA AUAAAUCA 38 INFORMATION FOR SEQ ID NO:908: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:908: UUAUCUGUAU UUUAAAG 17 INFORMATION FOR SEQ ID NO:909: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:909: CUUUAAAACU GAUGAGGCCG AAAGGCCGAA ACAGAUAA 38 INFORMATION FOR SEQ ID NO:910: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 262 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:910: AUCUGUAUUU

UAAAGGA

17 INFORMATION FOR SEQ ID NO:911: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:911: UCCUUUAACU GAUGAGGCCG AAAGGCCGAA AUACAGAU 38 INFORMATION FOR SEQ ID NO:912: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:912: UCUGUAUUUU AAAGGAU 17 INFORMATION FOR SEQ ID NO:913: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:913: AUCCUUUACU GAUGAGGCCG AAAGGCCGAA AAUACAGA 38 INFORMATION FOR SEQ ID NO:914: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:914: CUGUAUUUUA AAGGAUC 17 INFORMATION FOR SEQ ID NO:915: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:915: GAUCCUUUCU GAUGAGGCCG AAAGGCCGAA AAAUACAG 38 INFORMATION FOR SEQ ID NO:916: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:916: UGUAUUUUAA AGGAUCC 17 INFORMATION FOR SEQ ID NO:917: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:917: GGAUCCUUCU GAUGAGGCCG AAAGGCCGAA AAAAUACA 38 INFORMATION FOR SEQ ID NO:918: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:918: UAAAGGAUCC AACAGAU 17 INFORMATION FOR SEQ ID NO:919: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:919: AUCUGUUGCU GAUGAGGCCG AAAGGCCGAA AUCCUUUA 38 INFORMATION FOR SEQ ID NO:920: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:920: CAACAGAUCA GUAUUUU 17 INFORMATION FOR SEQ ID NO:921: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:921: AAAAUACUCU GAUGAGGCCG AAAGGCCGAA AUCUGUUG 38 INFORMATION FOR SEQ ID NO:922: SEQUENCE CHARACTERISTICS: 2(04- LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:922: AGAUCAGUAU UUUUUCC 17 INFORMATION FOR SEQ ID NO:923: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:923: GGAAAAAACU GAUGAGGCCG AAAGGCCGAA ACUGAUCU 38 INFORMATION FOR SEQ ID NO:924: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear a (xi) SEQUENCE DESCRIPTION: SEQ ID NO:924: AUCAGUAUUU UUUCCUG 17 INFORMATION FOR SEQ ID NO:925: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:925: CAGGAAAACU GAUGAGGCCG AAAGGCCGAA AUACUGAU 38 INFORMATION FOR SEQ ID NO:926: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:926: UCAGUAUUUU UUCCUGU 17 INFORMATION FOR SEQ ID N0:927: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:927: ACAGGAAACU GAUGAGGCCG AAAGGCCGAA AAUACUGA 3R 205 S(2) INFORMATION FOR SEQ ID NO:928: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:928: CAGUAUUUUU UCCUGUG 17 INFORMATION FOR SEQ ID NO:929: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:929: CACAGGAACU GAUGAGGCCG AAAGGCCGAA AAAUACUG 38 INFORMATION FOR SEQ ID NO:930: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:930: AGUAUUUUUU CCUGUGA 17 S(2) INFORMATION FOR SEQ ID NO:931: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:931: UCACAGGACU GAUGAGGCCG AAAGGCCGAA AAAAUACU 38 INFORMATION FOR SEQ ID N0:932: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:932: GUAUUUUUUC CUGUGAU 17 INFORMATION FOR SEQ ID NO:933: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:933: AUCACAGGCU GAUGAGGCCG AAAGGCCGAA AAAAAUAC 38 200(b INFORMATION FOR SEQ ID NO:934: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:934: UAUUUUUUCC UGUGAUG 17 INFORMATION FOR SEQ ID NO:935: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:935: CAUCACAGCU GAUGAGGCCG AAAGGCCGAA AAAAAAUA 38 INFORMATION FOR SEQ ID NO:936: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S" TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:936: UGAUGGGUUU UUUGAAA 17 INFORMATION FOR SEQ ID NO:937: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:937: UUUCAAAACU GAUGAGGCCG AAAGGCCGAA ACCCAUCA 38 INFORMATION FOR SEQ ID NO:938: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:938: GAUGGGUUUU UUGAAAU 17 INFORMATION FOR SEQ ID NO:939: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:939: 7 AUUUCAAACU GAUGAGGCCG AAAGGCCGAA AACCCAUC 38 INFORMATION FOR SEQ ID NO:940: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:940: AUGGGUUUUU UGAAAUU 17 INFORMATION FOR SEQ ID NO:941: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:941: AAUUUCAACU GAUGAGGCCG AAAGGCCGAA AAACCCAU 38 INFORMATION FOR SEQ ID NO:942: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 0, (xi) SEQUENCE DESCRIPTION: SEQ ID NO:942: UGGGUUUUUU GAAAUUU 17 INFORMATION FOR SEQ ID NO:943: SEQUENCE

CHARACTERISTICS:

loe LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single O TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:943: AAAUUUCACU GAUGAGGCCG AAAGGCCGAA AAAACCCA 38 INFORMATION FOR SEQ ID NO:944: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:944: GGGUUUUUUG AAAUUUG 17 INFORMATION FOR SEQ ID NO:945: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear V (xi) SEQUENCE DESCRIPTION: SEQ ID NO:945: CAAAUUUCCU GAUGAGGCCG AAAGGCCGAA AAAAACCC 38 INFORMATION FOR SEQ ID NO:946: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:946: UUUGAAAUUU GACACAU 17 INFORMATION FOR SEQ ID NO:947: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:947: AUGUGUCACU GAUGAGGCCG AAAGGCCGAA AUUUCAAA 38 INFORMATION FOR SEQ ID NO:948: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:948: UUGAAAUUUG ACACAUU 17 INFORMATION FOR SEQ ID NO:949: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:949: AAUGUGUCCU GAUGAGGCCG AAAGGCCGAA AAUUUCAA 38 INFORMATION FOR SEQ ID NO:950: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:950: UGACACAUUA AAAGGUA 17 INFORMATION FOR SEQ ID NO:951: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 2

C?

TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:951: UACCUUUUCU GAUGAGGCCG AAAGGCCGAA AUGUGUCA 38 INFORMATION FOR SEQ ID NO:952: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:952: GACACAUUAA AAGGUAC 17 INFORMATION FOR SEQ ID NO:953: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:953: GUACCUUUCU GAUGAGGCCG AAAGGCCGAA AAUGUGUC 38 INFORMATION FOR SEQ ID NO:954: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:954: S UAAAAGGUAC UCCAGUA 17 INFORMATION FOR SEQ ID NO:955: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:955: UACUGGAGCU GAUGAGGCCG AAAGGCCGAA ACCUUUUA 38 INFORMATION FOR SEQ ID NO:956: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:956: ACUCCAGUAU UUCACUU 17 INFORMATION FOR SEQ ID NO:957: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs 270 TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:957: AAGUGAAACU GAUGAGGCCG AAAGGCCGAA ACUGGAGU 38 INFORMATION FOR SEQ ID NO:958: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:958: UCCAGUAUUU CACUUUU 17 INFORMATION FOR SEQ ID NO:959: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:959: AAAAGUGACU GAUGAGGCCG AAAGGCCGAA AUACUGGA 38 INFORMATION FOR SEQ ID NO:960: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single o TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:960: CCAGUAUUUC ACUUUUC 17 INFORMATION FOR SEQ ID NO:961: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:961: GAAAAGUGCU GAUGAGGCCG AAAGGCCGAA AAUACUGG 38 INFORMATION FOR SEQ ID NO:962: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:962: CAGUAUUUCA CUUUUCU 17 INFORMATION FOR SEQ ID NO:963: 271t SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:963: AGAAAAGUCU GAUGAGGCCG AAAGGCCGAA AAAUACUG 38 INFORMATION FOR SEQ ID NO:964: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:964: AUUUCACUUU UCUCGAU 17 INFORMATION FOR SEQ ID NO:965: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:965: AUCGAGAACU GAUGAGGCCG AAAGGCCGAA AGUGAAAU 38 INFORMATION FOR SEQ ID NO:966: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:966: UUUCACUUUU CUCGAUC 17 INFORMATION FOR SEQ ID NO:967: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:967: GAUCGAGACU GAUGAGGCCG AAAGGCCGAA AAGUGAAA 38 INFORMATION FOR SEQ ID NO:968: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:968: UUCACUUUUC UCGAUCA Z72 INFORMATION FOR SEQ ID NO:969: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:969: UGAUCGAGCU GAUGAGGCCG AAAGGCCGAA AAAGUGAA 38 INFORMATION FOR SEQ ID NO:970: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:970: ACUUUUCUCG AUCACUA 17 INFORMATION FOR SEQ ID NO:971: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:971: UAGUGAUCCU GAUGAGGCCG AAAGGCCGAA AGAAAAGU 38 •38 INFORMATION FOR SEQ ID NO:972: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:972: UUCUCGAUCA CUAAACA 17 INFORMATION FOR SEQ ID NO:973: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:973: UGUUUAGUCU GAUGAGGCCG AAAGGCCGAA AUCGAGAA 38 INFORMATION FOR SEQ ID NO:974: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:974: 2773 CGAUCACUAA ACAUAUG 17 INFORMATION FOR SEQ ID NO:975: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:975: CAUAUGUUCU GAUGAGGCCG AAAGGCCGAA AGUGAUCG 38 INFORMATION FOR SEQ ID NO:976: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:976: CUAAACAUAU GCAUAUA 17 INFORMATION FOR SEQ ID NO:977: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:977: UAUAUGCACU GAUGAGGCCG AAAGGCCGAA AUGUUUAG 38 INFORMATION FOR SEQ ID NO:978: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:978: AUAUGCAUAU AUUUUUA 17 INFORMATION FOR SEQ ID NO:979: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:979: UAAAAAUACU GAUGAGGCCG AAAGGCCGAA AUGCAUAU 38 INFORMATION FOR SEQ ID NO:980: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 274 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:980: AUGCAUAUAU UUUUAAA 17 INFORMATION FOR SEQ ID NO:981: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:981: UUUAAAAACU GAUGAGGCCG AAAGGCCGAA AUAUGCAU 38 INFORMATION FOR SEQ ID NO:982: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:982: GCAUAUAUUU UUAAAAA *17 INFORMATION FOR SEQ ID NO:983: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:983: UUUUUAAACU GAUGAGGCCG AAAGGCCGAA AUAUAUGC 38 INFORMATION FOR SEQ ID NO:984: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:984: CAUAUAUUUU UAAAAAU 17 INFORMATION FOR SEQ ID NO:985: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:985: AUUUUUAACU GAUGAGGCCG AAAGGCCGAA AAUAUAUG 38 INFORMATION FOR SEQ ID NO:986: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid 275 W(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:986: AUAUAUUUUU AAAAAUC 17 INFORMATION FOR SEQ ID NO:987: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:987: GAUUUUUACU GAUGAGGCCG AAAGGCCGAA AAAUAUAU 38 INFORMATION FOR SEQ ID NO:988: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:988: SUAUAUUUUUA AAAAUCA 17 INFORMATION FOR SEQ ID NO:989: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:989: UGAUUUUUCU GAUGAGGCCG AAAGGCCGAA AAAAUAUA 38 INFORMATION FOR SEQ ID NO:990: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:990: AUAUUUUUAA AAAUCAG 17 INFORMATION FOR SEQ ID NO:991: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:991: CUGAUUUUCU GAUGAGGCCG AAAGGCCGAA AAAAAUAU 38 INFORMATION FOR SEQ ID NO:992: 27G SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:992: UUAAAAAUCA GUAAAAG 17 INFORMATION FOR SEQ ID NO:993: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:993: CUUUUACUCU GAUGAGGCCG AAAGGCCGAA AUUUUUAA 38 INFORMATION FOR SEQ ID NO:994: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:994: AAAUCAGUAA AAGCAUU 17 INFORMATION FOR SEQ ID NO:995: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:995: 9* AAUGCUUUCU GAUGAGGCCG AAAGGCCGAA ACUGAUUU 38 INFORMATION FOR SEQ ID NO:996: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:996: AAAAGCAUUA CUCUAAG 17 INFORMATION FOR SEQ ID NO:997: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:997: CUUAGAGUCU GAUGAGGCCG AAAGGCCGAA AUGCUUUU 38 INFORMATION FOR SEQ ID NO:998: 2-77 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:998: AAAGCAUUAC UCUAAGU 17 INFORMATION FOR SEQ ID NO:999: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:999: ACUUAGAGCU GAUGAGGCCG AAAGGCCGAA AAUGCUUU 38 INFORMATION FOR SEQ ID NO:1000: SEQUENCE CHARACTERISTICS: S* LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1000: GCAUUACUCU AAGUGUA 17 S' INFORMATION FOR SEQ ID NO:1001: SEQUENCE CHARACTERISTICS: S" LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1001: UACACUUACU GAUGAGGCCG AAAGGCCGAA AGUAAUGC 38 INFORMATION FOR SEQ ID NO:1002: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1002: AUUACUCUAA GUGUAGA 17 INFORMATION FOR SEQ ID NO:1003: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1003: UCUACACUCU GAUGAGGCCG AAAGGCCGAA AGAGUAAU

AQ

270 INFORMATION FOR SEQ ID NO:1004: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1004: CUAAGUGUAG ACUUAAU 17 INFORMATION FOR SEQ ID NO:1005: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1005: AUUAAGUCCU GAUGAGGCCG AAAGGCCGAA ACACUUAG 38 INFORMATION FOR SEQ ID NO:1006: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1006: UGUAGACUUA AUACCAU 17 INFORMATION FOR SEQ ID NO:1007: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1007: AUGGUAUUCU GAUGAGGCCG AAAGGCCGAA AGUCUACA 38 INFORMATION FOR SEQ ID NO:1008: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1008: GUAGACUUAA UACCAUG 17 INFORMATION FOR SEQ ID NO:1009: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1009: 27q CAUGGUAUCU GAUGAGGCCG AAAGGCCGAA AAGUCUAC 38 INFORMATION FOR SEQ ID NO:1010: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1010: GACUUAAUAC CAUGUGA 17 INFORMATION FOR SEQ ID NO:1011: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1011: UCACAUGGCU GAUGAGGCCG AAAGGCCGAA AUUAAGUC 38 INFORMATION FOR SEQ ID NO:1012: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1012: UGUGACAUUU AAUCCAG 17 INFORMATION FOR SEQ ID NO:1013: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1013: CUGGAUUACU GAUGAGGCCG AAAGGCCGAA AUGUCACA 38 INFORMATION FOR SEQ ID NO:1014: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1014: GUGACAUUUA AUCCAGA 17 INFORMATION FOR SEQ ID NO:1015: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 2'80C S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1015: UCUGGAUUCU GAUGAGGCCG AAAGGCCGAA AAUGUCAC 38 INFORMATION FOR SEQ ID NO:1016: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1016: UGACAUUUAA UCCAGAU 17 INFORMATION FOR SEQ ID NO:1017: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1017: AUCUGGAUCU GAUGAGGCCG AAAGGCCGAA AAAUGUCA 38 INFORMATION FOR SEQ ID NO:1018: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1018: CAUUUAAUCC AGAUUGU 17 INFORMATION FOR SEQ ID NO:1019: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1019: ACAAUCUGCU GAUGAGGCCG AAAGGCCGAA AUUAAAUG 38 INFORMATION FOR SEQ ID NO:1020: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1020: AUCCAGAUUG UAAAUGC 17 INFORMATION FOR SEQ ID NO:1021: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 23 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1021: GCAUUUACCU GAUGAGGCCG AAAGGCCGAA AUCUGGAU 38 INFORMATION FOR SEQ ID NO:1022: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1022: CAGAUUGUAA AUGCUCA 17 INFORMATION FOR SEQ ID NO:1023: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1023: S* UGAGCAUUCU GAUGAGGCCG AAAGGCCGAA ACAAUCUG 38 99 .93 INFORMATION FOR SEQ ID NO:1024: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1024: S UAAAUGCUCA UUUAUGG 17 INFORMATION FOR SEQ ID NO:1025: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1025: CCAUAAAUCU GAUGAGGCCG AAAGGCCGAA AGCAUUUA 38 INFORMATION FOR SEQ ID NO:1026: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1026: AUGCUCAUUU AUGGUUA 17 INFORMATION FOR SEQ ID NO:1027: SEQUENCE CHARACTERISTICS: 282 LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1027: UAACCAUACU GAUGAGGCCG AAAGGCCGAA AUGAGCAU 38 INFORMATION FOR SEQ ID NO:1028: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1028: UGCUCAUUUA UGGUUAA 17 INFORMATION FOR SEQ ID NO:1029: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1029: UUAACCAUCU GAUGAGGCCG AAAGGCCGAA AAUGAGCA 38 INFORMATION FOR SEQ ID NO:1030: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1030: GCUCAUUUAU GGUUAAU 17 INFORMATION FOR SEQ ID NO:1031: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1031: AUUAACCACU GAUGAGGCCG AAAGGCCGAA AAAUGAGC 38 INFORMATION FOR SEQ ID NO:1032: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1032: UUUAUGGUUA AUGACAU 17 235 INFORMATION FOR SEQ ID NO:1033: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1033: AUGUCAUUCU GAUGAGGCCG AAAGGCCGAA ACCAUAAA 38 INFORMATION FOR SEQ ID NO:1034: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1034: UUAUGGUUAA UGACAUU 17 INFORMATION FOR SEQ ID NO:1035: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1035: AAUGUCAUCU GAUGAGGCCG AAAGGCCGAA AACCAUAA 38 INFORMATION FOR SEQ ID NO:1036: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1036: .AAUGACAUUG AAGGUAC 17 INFORMATION FOR SEQ ID NO:1037: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1037: GUACCUUCCU GAUGAGGCCG AAAGGCCGAA AUGUCAUU 38 INFORMATION FOR SEQ ID NO:1038: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1038: UUGAAGGUAC AUUUAUU 23-4- INFORMATION FOR SEQ ID NO:1039: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1039: AAUAAAUGCU GAUGAGGCCG AAAGGCCGAA ACCUUCAA 38 INFORMATION FOR SEQ ID NO:1040: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1040: AGGUACAUUU AUUGUAC 17 INFORMATION FOR SEQ ID NO:1041: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1041: GUACAAUACU GAUGAGGCCG AAAGGCCGAA AUGUACCU 38 INFORMATION FOR SEQ ID NO:1042: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1042: oo* GGUACAUUUA UUGUACC 17 INFORMATION FOR SEQ ID NO:1043: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1043: GGUACAAUCU GAUGAGGCCG AAAGGCCGAA AAUGUACC 38 INFORMATION FOR SEQ ID NO:1044: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1044: GUACAUUUAU

UGUACCA

INFORMATION FOR SEQ ID NO:1045: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1045: UGGUACAACU GAUGAGGCCG AAAGGCCGAA AAAUGUAC 38 INFORMATION FOR SEQ ID NO:1046: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1046: ACAUUUAUUG UACCAAA 17 17 INFORMATION FOR SEQ ID NO:1047: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1047: UUUGGUACCU GAUGAGGCCG AAAGGCCGAA AUAAAUGU 38 INFORMATION FOR SEQ ID NO:1048: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1048: UUUAUUGUAC CAAACCA 17 INFORMATION FOR SEQ ID NO:1049: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1049: UGGUUUGGCU GAUGAGGCCG AAAGGCCGAA ACAAUAAA 38 INFORMATION FOR SEQ ID NO:1050: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1050: CAAACCAUUU UAUGAGU 17 INFORMATION FOR SEQ ID NO:1051: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1051: ACUCAUAACU GAUGAGGCCG AAAGGCCGAA AUGGUUUG 38 INFORMATION FOR SEQ ID NO:1052: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1052: AAACCAUUUU AUGAGUU 17 INFORMATION FOR SEQ ID NO:1053: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1053: AACUCAUACU GAUGAGGCCG AAAGGCCGAA AAUGGUUU 38 INFORMATION FOR SEQ ID NO:1054: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1054: AACCAUUUUA UGAGUUU 17 INFORMATION FOR SEQ ID NO:1055: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1055: AAACUCAUCU GAUGAGGCCG AAAGGCCGAA AAAUGGUU 38 INFORMATION FOR SEQ ID NO:1056: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single 237 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1056: ACCAUUUUAU GAGUUUU 17 17 INFORMATION FOR SEQ ID NO:1057: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1057: AAAACUCACU GAUGAGGCCG AAAGGCCGAA AAAAUGGU 38 INFORMATION FOR SEQ ID NO:1058: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1058: UUAUGAGUUU UCUGUUA 17 INFORMATION FOR SEQ ID NO:1059: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1059: UAACAGAACU GAUGAGGCCG AAAGGCCGAA ACUCAUAA 38 INFORMATION FOR SEQ ID NO:1060: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1060: UAUGAGUUUU CUGUUAG 17 INFORMATION FOR SEQ ID NO:1061: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1061: CUAACAGACU GAUGAGGCCG AAAGGCCGAA AACUCAUA 38 INFORMATION FOR SEQ ID NO:1062: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs 23g TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1062: AUGAGUUUUC UGUUAGC 17 INFORMATION FOR SEQ ID NO:1063: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1063: GCUAACAGCU GAUGAGGCCG AAAGGCCGAA AAACUCAU 38 INFORMATION FOR SEQ ID NO:1064: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1064: UGAGUUUUCU GUUAGCU 17 INFORMATION FOR SEQ ID NO:1065: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1065: AGCUAACACU GAUGAGGCCG AAAGGCCGAA AAAACUCA 38

S.

INFORMATION FOR SEQ ID NO:1066: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1066: UUUUCUGUUA GCUUGCU 17 INFORMATION FOR SEQ ID NO:1067: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1067: AGCAAGCUCU GAUGAGGCCG AAAGGCCGAA ACAGAAAA 38 INFORMATION FOR SEQ ID NO:1068: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1068: UUUCUGUUAG CUUGCUU 17 INFORMATION FOR SEQ ID NO:1069: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1069: AAGCAAGCCU GAUGAGGCCG AAAGGCCGAA AACAGAAA 38 INFORMATION FOR SEQ ID NO:1070: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1070: UGUUAGCUUG CUUUAAA 17 INFORMATION FOR SEQ ID NO:1071: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 4. TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1071: UUUAAAGCCU GAUGAGGCCG AAAGGCCGAA AGCUAACA 38 S* INFORMATION FOR SEQ ID NO:1072: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1072: AGCUUGCUUU AAAAAUU 17 INFORMATION FOR SEQ ID NO:1073: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1073: AAUUUUUACU GAUGAGGCCG AAAGGCCGAA AGCAAGCU S(2) INFORMATION FOR SEQ ID NO:1074: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1074: GCUUGCUUUA AAAAUUA INFORMATION FOR SEQ ID NO:1075: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1075: UAAUUUUUCU GAUGAGGCCG AAAGGCCGAA AAGCAAGC 38 99 0 INFORMATION FOR SEQ ID NO:1076: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1076: CUUGCUUUAA AAAUUAU 17 INFORMATION FOR SEQ ID NO:1077: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1077: AUAAUUUUCU GAUGAGGCCG AAAGGCCGAA AAAGCAAG 38 INFORMATION FOR SEQ ID NO:1078: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1078: UUAAAAUUA UUACUGU 17 INFORMATION FOR SEQ ID NO:1079: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1079: ACAGUAAUCU GAUGAGGCCG AAAGGCCGAA AUUUUUAA 38 INFORMATION FOR SEQ ID NO:1080: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1080: UAAAAAUUAU UACUGUA 17 INFORMATION FOR SEQ ID NO:1081: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1081: UACAGUAACU GAUGAGGCCG AAAGGCCGAA AAUUUUUA 38 *.*38 INFORMATION FOR SEQ ID NO:1082: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1082: S AAAAUUAUUA CUGUAAG 17 INFORMATION FOR SEQ ID NO:1083: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1083: CUUACAGUCU GAUGAGGCCG AAAGGCCGAA AUAAUUUUT 38 INFORMATION FOR SEQ ID NO:1084: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1084: AAAUUAUUAC UGUAAGA 17 INFORMATION FOR SEQ ID NO:1085: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1085: UCUUACAGCU GAUGAGGCCG AAAGGCCGAA AAUAAUUU 38 INFORMATION FOR SEQ ID NO:1086: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1086: AUUACUGUAA GAAAUAG 17 INFORMATION FOR SEQ ID NO:1087: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1087: CUAUUUCUCU GAUGAGGCCG AAAGGCCGAA ACAGUAAU 38 INFORMATION FOR SEQ ID NO:1088: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1088: UAAGAAAUAG UUUUAUA 17 INFORMATION FOR SEQ ID NO:1089: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1089: UAUAAAACCU GAUGAGGCCG AAAGGCCGAA AUUUCUUA 38 INFORMATION FOR SEQ ID NO:1090: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1090: GAAAUAGUUU UAUAAAA 17 INFORMATION FOR SEQ ID NO:1091: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid 2q3 STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1091: UUUUAUAACU GAUGAGGCCG AAAGGCCGAA ACUAUUUC 38 INFORMATION FOR SEQ ID NO:1092: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1092: AAAUAGUUUU AUAAAAA 17 INFORMATION FOR SEQ ID NO:1093: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1093: SUUUUUAUACU GAUGAGGCCG AAAGGCCGAA AACUAUUU 38 38 INFORMATION FOR SEQ ID NO:1094: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1094: AAUAGUUUUA UAAAAAA 17 INFORMATION FOR SEQ ID NO:1095: e SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1095: UUUUUUAUCU GAUGAGGCCG AAAGGCCGAA AAACUAUU 38 INFORMATION FOR SEQ ID NO:1096: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1096: AUAGUUUUAU AAAAAAU 17 INFORMATION FOR SEQ ID NO:1097: ZQ4 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1097: AUUUUUUACU GAUGAGGCCG AAAGGCCGAA AAAACUAU 38 INFORMATION FOR SEQ ID NO:1098: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1098: AGUUUUAUAA AAAAUUA 17 INFORMATION FOR SEQ ID NO:1099: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S. TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1099: SUAAUUUUUCU GAUGAGGCCG AAAGGCCGAA AUAAAACU 38 INFORMATION FOR SEQ ID NO:1100: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1100: UAAAAAAUUA UAUUUUU 17 INFORMATION FOR SEQ ID NO:1101: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1101: AAAAAUAUCU GAUGAGGCCG AAAGGCCGAA AUUUUUUA 38 INFORMATION FOR SEQ ID NO:1102: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1102: AAAAAAUUAU AUUUUUA 17 INFORMATION FOR SEQ ID NO:1103: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1103: UAAAAAUACU GAUGAGGCCG AAAGGCCGAA AAUUUUUU 38 INFORMATION FOR SEQ ID NO:1104: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1104: AAAAUUAUAU UUUUAUU 17 INFORMATION FOR SEQ ID NO:1105: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1105: AAUAAAAACU GAUGAGGCCG AAAGGCCGAA AUAAUUUU 38 INFORMATION FOR SEQ ID NO:1106: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1106: AAUUAUAUUU UUAUUCA 17 INFORMATION FOR SEQ ID NO:1107: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1107: UGAAUAAACU GAUGAGGCCG AAAGGCCGAA AUAUAAUU 38 INFORMATION FOR SEQ ID NO:1108: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1108: AUUAUAUUUU UAUUCAG INFORMATION FOR SEQ ID NO:1109: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1109: CUGAAUAACU GAUGAGGCCG AAAGGCCGAA AAUAUAAU 38 INFORMATION FOR SEQ ID NO:1110: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1110: UUAUAUUUUU AUUCAGU 17 INFORMATION FOR SEQ ID NO:1111: SEQUENCE CHARACTERISTICS: S* LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1111: ACUGAAUACU GAUGAGGCCG AAAGGCCGAA AAAUAUAA 38 INFORMATION FOR SEQ ID NO:1112: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1112: UAUAUUUUUA UUCAGUA 17 INFORMATION FOR SEQ ID NO:1113: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1113: UACUGAAUCU GAUGAGGCCG AAAGGCCGAA AAAAUAUA 38 INFORMATION FOR SEQ ID NO:1114: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1114: 2Q7 AUAUUUUUAU UCAGUAA 17 INFORMATION FOR SEQ ID NO:1115: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1115: UUACUGAACU GAUGAGGCCG AAAGGCCGAA AAAAAUAU 38 INFORMATION FOR SEQ ID NO:1116: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1116: S* AUUUUUAUUC AGUAAUU 17 INFORMATION FOR SEQ ID NO:1117: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1117: S AAUUACUGCU GAUGAGGCCG AAAGGCCGAA AUAAAAAU 38 INFORMATION FOR SEQ ID NO:1118: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid S. STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1118: UUUUUAUUCA

GUAAUUU

17 INFORMATION FOR SEQ ID NO:1119: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1119: AAAUUACUCU GAUGAGGCCG AAAGGCCGAA AAUAAAAA 38 INFORMATION FOR SEQ ID NO:1120: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1120: UAUUCAGUAA

UUUAAUU

17 INFORMATION FOR SEQ ID NO:1121: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1121: AAUUAAAUCU GAUGAGGCCG AAAGGCCGAA ACUGAAUA 38 INFORMATION FOR SEQ ID NO:1122: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1122: UCAGUAAUUU

AAUUUUG

17 INFORMATION FOR SEQ ID NO:1123: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1123: CAAAAUUACU GAUGAGGCCG AAAGGCCGAA AUUACUGA 38 3 8 INFORMATION FOR SEQ ID NO:1124: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid S: STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1124: CAGUAAUUUA AUUUUGU 17 INFORMATION FOR SEQ ID NO:1125: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1125: ACAAAAUUCU GAUGAGGCCG AAAGGCCGAA AAUUACUG 38 INFORMATION FOR SEQ ID NO:1126: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1126: AGUAAUUUAA

UUUUGUA

17 INFORMATION FOR SEQ ID NO:1127: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1127: UACAAAAUCU GAUGAGGCCG AAAGGCCGAA AAAUUACU 38 INFORMATION FOR SEQ ID NO:1128: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1128: AAUUUAAUUU UGUAAAU o 1 7 INFORMATION FOR SEQ ID NO:1129: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1129: AUUUACAACU GAUGAGGCCG AAAGGCCGAA AUUAAAUU 38 INFORMATION FOR SEQ ID NO:1130: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1130: AUUUAAUUUU GUAAAUG 17 INFORMATION FOR SEQ ID NO:1131: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1131: CAUUUACACU GAUGAGGCCG AAAGGCCGAA AAUUAAAU 38 INFORMATION FOR SEQ ID NO:1132: SEQUENCE CHARACTERISTICS: 300 LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1132: UUUAAUUUUG UAAAUGC 17 INFORMATION FOR SEQ ID NO:1133: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1133: GCAUUUACCU GAUGAGGCCG AAAGGCCGAA AAAUUAAA 38 INFORMATION FOR SEQ ID NO:1134: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S( D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1134: AAUUUUGUAA AUGCCAA 17 INFORMATION FOR SEQ ID NO:1135: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1135: UUGGCAUUCU GAUGAGGCCG AAAGGCCGAA ACAAAAUU 38 INFORMATION FOR SEQ ID NO:1136: 9 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1136: AAAAACGUUU UUUGCUG 17 INFORMATION FOR SEQ ID NO:1137: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1137: CAGCAAAACU GAUGAGGCCG AAAGGCCGAA ACGUUUUU a0

J

INFORMATION FOR SEQ ID NO:1138: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1138: AAAACGUUUU UUGCUGC 17 INFORMATION FOR SEQ ID NO:1139: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1139: GCAGCAAACU GAUGAGGCCG AAAGGCCGAA AACGUUUU 38 INFORMATION FOR SEQ ID NO:1140: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1140: AAACGUUUUU

UGCUGCU

17 INFORMATION FOR SEQ ID NO:1141: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1141: SAGCAGCAACU GAUGAGGCCG AAAGGCCGAA AAACGUUU 38 INFORMATION FOR SEQ ID NO:1142: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1142: AACGUUUUUU GCUGCUA 17 INFORMATION FOR SEQ ID NO:1143: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1143: UAGCAGCACU GAUGAGGCCG AAAGGCCGAA AAAACGUU o0 302 INFORMATION FOR SEQ ID NO:1144: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1144: ACGUUUUUUG

CUGCUAU

17 INFORMATION FOR SEQ ID NO:1145: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1145: AUAGCAGCCU GAUGAGGCCG AAAGGCCGAA

AAAAACGU

*38 INFORMATION FOR SEQ ID NO:1146: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1146: UUGCUGCUAU

GGUCUUA

1 7 9 INFORMATION FOR SEQ ID NO:1147: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1147: UAAGACCACU GAUGAGGCCG AAAGGCCGAA

AGCAGCAA

INFORMATION FOR SEQ ID NO:1148: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1148: GCUAUGGUCU

UAGCCUG

INFORMATION FOR SEQ ID NO:1149: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1149: CAGGCUAACU GAUGAGGCCG AAAGGCCGAA ACCAUAGC 38 INFORMATION FOR SEQ ID NO:1150: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1150: UAUGGUCUUA GCCUGUA 17 INFORMATION FOR SEQ ID NO:1151: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1151: UACAGGCUCU GAUGAGGCCG AAAGGCCGAA AGACCAUA 38 INFORMATION FOR SEQ ID NO:1152: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear e*

S

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1152: AUGGUCUUAG CCUGUAG 17 INFORMATION FOR SEQ ID NO:1153: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1153: CUACAGGCCU GAUGAGGCCG AAAGGCCGAA AAGACCAU 38 INFORMATION FOR SEQ ID NO:1154: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1154: UAGCCUGUAG ACAUGCU 17 INFORMATION FOR SEQ ID NO:1155: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 304- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1155: AGCAUGUCCU GAUGAGGCCG AAAGGCCGAA ACAGGCUA 38 INFORMATION FOR SEQ ID NO:1156: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1156: CUGCUAGUAU CAGAGGG 17 INFORMATION FOR SEQ ID NO:1157: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1157: CCCUCUGACU GAUGAGGCCG AAAGGCCGAA ACUAGCAG 38 INFORMATION FOR SEQ ID NO:1158: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1158: S GCUAGUAUCA GAGGGGC 17 INFORMATION FOR SEQ ID NO:1159: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:1159: GCCCCUCUCU GAUGAGGCCG AAAGGCCGAA AUACUAGC 38 INFORMATION FOR SEQ ID NO:1160: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1160: GGGGCAGUAG AGCUUGG 17 INFORMATION FOR SEQ ID NO:1161: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 3015 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1161: CCAAGCUCCU GAUGAGGCCG AAAGGCCGAA ACUGCCCC 38 INFORMATION FOR SEQ ID NO:1162: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1162: GUAGAGCUUG GACAGAA 17 INFORMATION FOR SEQ ID NO:1163: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1163: UUCUGUCCCU GAUGAGGCCG AAAGGCCGAA AGCUCUAC 38 INFORMATION FOR SEQ ID NO:1164: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1164: SAAGAAACUUG GUGUUAG 17 INFORMATION FOR SEQ ID NO:1165: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1165: CUAACACCCU GAUGAGGCCG AAAGGCCGAA AGUUUCUU 38 INFORMATION FOR SEQ ID NO:1166: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1166: CUUGGUGUUA GGUAAUU 17 INFORMATION FOR SEQ ID NO:1167: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs 306 TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1167: AAUUACCUCU GAUGAGGCCG AAAGGCCGAA ACACCAAG 38 INFORMATION FOR SEQ ID NO:1168: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1168: UUGGUGUUAG GUAAUUG 17 INFORMATION FOR SEQ ID NO:1169: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1169: CAAUUACCCU GAUGAGGCCG AAAGGCCGAA AACACCAA 38 INFORMATION FOR SEQ ID NO:1170: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1170: UGUUAGGUAA UUGACUA 17 INFORMATION FOR SEQ ID NO:1171: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1171: UAGUCAAUCU GAUGAGGCCG AAAGGCCGAA ACCUAACA 38 INFORMATION FOR SEQ ID NO:1172: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1172: UAGGUAAUUG ACUAUGC 17 INFORMATION FOR SEQ ID NO:1173:

I

7 9 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1173: GCAUAGUCCU GAUGAGGCCG AAAGGCCGAA AUUACCUA INFORMATION FOR SEQ ID NO:1174: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1174: AAUUGACUAU GCACUAG INFORMATION FOR SEQ ID NO:1175: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1175: CUAGUGCACU GAUGAGGCCG AAAGGCCGAA AGUCAAUU INFORMATION FOR SEQ ID NO:1176: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1176: UAUGCACUAG UAUUUCA INFORMATION FOR SEQ ID NO:1177: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1177: UGAAAUACCU GAUGAGGCCG AAAGGCCGAA

AGUGCAUA

INFORMATION FOR SEQ ID NO:1178: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1178: GCACUAGUAU

UUCAGAC

303 INFORMATION FOR SEQ ID NO:1179: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1179: GUCUGAAACU GAUGAGGCCG AAAGGCCGAA ACUAGUGC 38 INFORMATION FOR SEQ ID NO:1180: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1180: ACUAGUAUUU CAGACUU 17 INFORMATION FOR SEQ ID NO:1181: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1181: AAGUCUGACU GAUGAGGCCG AAAGGCCGAA AUACUAGU 38 INFORMATION FOR SEQ ID NO:1182: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1182: CUAGUAUUUC AGACUUU 17 INFORMATION FOR SEQ ID NO:1183: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1183: AAAGUCUGCU GAUGAGGCCG AAAGGCCGAA AAUACUAG 38 INFORMATION FOR SEQ ID NO:1184: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1184: UAGUAUUUCA GACUUUU 17 INFORMATION FOR SEQ ID NO:1185: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1185: AAAAGUCUCU GAUGAGGCCG AAAGGCCGAA AAAUACUA 38 INFORMATION FOR SEQ ID NO:1186: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1186: UUCAGACUUU UUAAUUU 17 INFORMATION FOR SEQ ID NO:1187: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1187: AAAUUAAACU GAUGAGGCCG AAAGGCCGAA AGUCUGAA 38 INFORMATION FOR SEQ ID NO:1188: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1188: UCAGACUUUU UAAUUUU 17 INFORMATION FOR SEQ ID NO:1189: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1189: AAAAUUAACU GAUGAGGCCG AAAGGCCGAA AAGUCUGA 38 INFORMATION FOR SEQ ID NO:1190: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 310 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1190: CAGACUUUUU AAUUUUA 17 INFORMATION FOR SEQ ID NO:1191: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1191: UAAAAUUACU GAUGAGGCCG AAAGGCCGAA AAAGUCUG 38 INFORMATION FOR SEQ ID NO:1192: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1192: AGACUUUUUA AUUUUAU 17 17 INFORMATION FOR SEQ ID NO:1193: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1193: AUAAAAUUCU GAUGAGGCCG AAAGGCCGAA AAAAGUCU 38 INFORMATION FOR SEQ ID NO:1194: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1194: GACUUUUUAA UUUUAUA 17 INFORMATION FOR SEQ ID NO:1195: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1195: UAUAAAAUCU GAUGAGGCCG AAAGGCCGAA AAAAAGUC 38 INFORMATION FOR SEQ ID NO:1196: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid 3"' S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1196: UUUUUAAUUU UAUAUAU 17 INFORMATION FOR SEQ ID NO:1197: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1197: AUAUAUAACU GAUGAGGCCG AAAGGCCGAA AUUAAAAA 38 INFORMATION FOR SEQ ID NO:1198: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1198: UUUUAAUUUU AUAUAUA 17 INFORMATION FOR SEQ ID NO:1199:

S

SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1199: UAUAUAUACU GAUGAGGCCG AAAGGCCGAA AAUUAAAA 38 INFORMATION FOR SEQ ID NO:1200: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1200: UUUAAUUUUA UAUAUAU 17 INFORMATION FOR SEQ ID NO:1201: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1201: AUAUAUAUCU GAUGAGGCCG AAAGGCCGAA AAAUUAAA 38 INFORMATION FOR SEQ ID NO:1202: 3t2 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1202: UUAAUUUUAU AUAUAUA 17 INFORMATION FOR SEQ ID NO:1203: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1203: UAUAUAUACU GAUGAGGCCG AAAGGCCGAA AAAAUUAA 38 INFORMATION FOR SEQ ID NO:1204: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1204: AAUUUUAUAU AUAUAUA 17 INFORMATION FOR SEQ ID NO:1205: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1205: S UAUAUAUACU GAUGAGGCCG AAAGGCCGAA AUAAAAUU 38 INFORMATION FOR SEQ ID NO:1206: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1206: UUUUAUAUAU AUAUACA 17 INFORMATION FOR SEQ ID NO:1207: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1207: UGUAUAUACU GAUGAGGCCG AAAGGCCGAA AUAUAAAA 38 INFORMATION FOR SEQ ID NO:1208: 31f3 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1208: UUAUAUAUAU AUACAUU 17 INFORMATION FOR SEQ ID NO:1209: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1209: AAUGUAUACU GAUGAGGCCG AAAGGCCGAA AUAUAUAA 38 INFORMATION FOR SEQ ID NO:1210: SEQUENCE CHARACTERISTICS: S: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1210: AUAUAUAUAU ACAUUUU 17 INFORMATION FOR SEQ ID NO:1211: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1211: AAAAUGUACU GAUGAGGCCG AAAGGCCGAA AUAUAUAU 38 INFORMATION FOR SEQ ID NO:1212: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1212: AUAUAUAUAC AUUUUUU 17 INFORMATION FOR SEQ ID NO:1213: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1213: AAAAAAUGCU GAUGAGGCCG AAAGGCCGAA AUAUAUAU

-A

314 INFORMATION FOR SEQ ID NO:1214: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1214: AUAUACAUUU UUUUUCC 17 INFORMATION FOR SEQ ID NO:1215: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1215: GGAAAAAACU GAUGAGGCCG AAAGGCCGAA AUGUAUAU 38 INFORMATION FOR SEQ ID NO:1216: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1216: UAUACAUUUU UUUUCCU 17 INFORMATION FOR SEQ ID NO:1217: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1217: AGGAAAAACU GAUGAGGCCG AAAGGCCGAA AAUGUAUA 38 INFORMATION FOR SEQ ID NO:1218: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1218: AUACAUUUUU UUUCCUU 17 INFORMATION FOR SEQ ID NO:1219: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1219: 315 AAGGAAAACU GAUGAGGCCG AAAGGCCGAA AAAUGUAU 38 INFORMATION FOR SEQ ID NO:1220: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1220: UACAUUUUUU UUCCUUC 17 INFORMATION FOR SEQ ID NO:1221: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1221: GAAGGAAACU GAUGAGGCCG AAAGGCCGAA AAAAUGUA 38 INFORMATION FOR SEQ ID N0:1222: :o SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1222: ACAUUUUUUU UCCUUCU 17 INFORMATION FOR SEQ ID NO:1223: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1223: AGAAGGAACU GAUGAGGCCG AAAGGCCGAA AAAAAUGU 38 INFORMATION FOR SEQ ID NO:1224: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1224: CAUUUUUUUU CCUUCUG 17 INFORMATION FOR SEQ ID N0:1225: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1225: CAGAAGGACU GAUGAGGCCG AAAGGCCGAA AAAAAAUG 38 INFORMATION FOR SEQ ID NO:1226: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1226: AUUUUUUUUC CUUCUGC 17 INFORMATION FOR SEQ ID NO:1227: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1227: GCAGAAGGCU GAUGAGGCCG AAAGGCCGAA AAAAAAAU 38 INFORMATION FOR SEQ ID NO:1228: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1228: UUUUUUUUCC UUCUGCA INFORMATION FOR SEQ ID NO:1229: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1229: UGCAGAAGCU GAUGAGGCCG AAAGGCCGAA AAAAAAAA 38 INFORMATION FOR SEQ ID NO:1230: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1230: UUUUUCCUUC UGCAAUA 17 INFORMATION FOR SEQ ID NO:1231: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 317 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1231: UAUUGCAGCU GAUGAGGCCG AAAGGCCGAA AGGAAAAA 38 INFORMATION FOR SEQ ID NO:1232: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1232: UUUUCCUUCU GCAAUAC 17 INFORMATION FOR SEQ ID NO:1233: SEQUENCE CHARACTERISTICS: "o LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1233: S* GUAUUGCACU GAUGAGGCCG AAAGGCCGAA AAGGAAAA 38 INFORMATION FOR SEQ ID NO:1234: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 0. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1234: UCUGCAAUAC AUUUGAA 17 INFORMATION FOR SEQ ID NO:1235: I SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1235: UUCAAAUGCU GAUGAGGCCG AAAGGCCGAA AUUGCAGA 38 INFORMATION FOR SEQ ID NO:1236: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1236: CAAUACAUUU GAAAACU 17 INFORMATION FOR SEQ ID NO:1237: SEQUENCE CHARACTERISTICS: '315 LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1237: AGUUUUCACU GAUGAGGCCG AAAGGCCGAA AUGUAUUG 38 INFORMATION FOR SEQ ID NO:1238: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1238: AAUACAUUUG AAAACUU 17 INFORMATION FOR SEQ ID NO:1239: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1239: AAGUUUUCCU GAUGAGGCCG AAAGGCCGAA AAUGUAUU 38 INFORMATION FOR SEQ ID NO:1240: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1240: SUGAAAACUUG UUUGGGA 17 INFORMATION FOR SEQ ID NO:1241: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1241: UCCCAAACCU GAUGAGGCCG AAAGGCCGAA AGUUUUCA 38 INFORMATION FOR SEQ ID NO:1242: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1242: AAACUUGUUU GGGAGAC INFORMATION FOR SEQ ID NO:1243: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1243: GUCUCCCACU GAUGAGGCCG AAAGGCCGAA ACAAGUUU 38 INFORMATION FOR SEQ ID NO:1244: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1244: *AACUUGUUUG GGAGACU 17 INFORMATION FOR SEQ ID NO:1245: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1245: AGUCUCCCCU GAUGAGGCCG AAAGGCCGAA AACAAGUU 38 INFORMATION FOR SEQ ID NO:1246: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1246: SGGGAGACUCU GCAUUUU 17 INFORMATION FOR SEQ ID NO:1247: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1247: AAAAUGCACU GAUGAGGCCG AAAGGCCGAA AGUCUCCC 38 INFORMATION FOR SEQ ID NO:1248: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1248: CUCUGCAUUU UUUAUUG 320 INFORMATION FOR SEQ ID NO:1249: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1249: CAAUAAAACU GAUGAGGCCG AAAGGCCGAA AUGCAGAG 38 INFORMATION FOR SEQ ID NO:1250: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1250: S UCUGCAUUUU UAUUGU17 INFORMATION FOR SEQ ID NO:1251: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:1251: ACAAUAAACU GAUGAGGCCG AAAGGCCGAA AAUGCAGA 38 INFORMATION FOR SEQ ID NO:1252: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1252: CUGCAUUUU UAUUGUG 17 INFORMATION FOR SEQ ID NO:1253: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1253: CACAAUAACU GAUGAGGCCG AAAGGCCGAA AAAUGCAG 38 INFORMATION FOR SEQ ID NO:1254: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1254: UGCAUUUUU AUUGUGG 17 INFORMATION FOR SEQ ID NO:1255: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1255: CCACAAUACU GAUGAGGCCG AAAGGCCGAA AAAAUGCA 38 INFORMATION FOR SEQ ID NO:1256: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1256: GCAUUUUUUA

UUGUGGU

17 INFORMATION FOR SEQ ID NO:1257: SEQUENCE CHARACTERISTICS: S* LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1257: ACCACAAUCU GAUGAGGCCG AAAGGCCGAA AAAAAUGC 38 INFORMATION FOR SEQ ID NO:1258: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1258: CAUUUUUUAU UGUGGUU 17 INFORMATION FOR SEQ ID NO:1259: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1259: AACCACAACU GAUGAGGCCG AAAGGCCGAA AAAAAAUG 38 INFORMATION FOR SEQ ID NO:1260: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 522 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1260: AUUGUGGUUU UUUUGUU 17 INFORMATION FOR SEQ ID NO:1261: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1261: AACAAAAACU GAUGAGGCCG AAAGGCCGAA ACCACAAU 38 INFORMATION FOR SEQ ID NO:1262: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1262: UUGUGGIUUUU UUUGUUA 17 INFORMATION FOR SEQ ID NO:1263: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1263: 0o, UAACAAAACU GAUGAGGCCG AAAGGCCGAA AACCACAA 38 INFORMATION FOR SEQ ID NO:1264: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1264: UGUGGUU UU UUGUUAU 17 INFORMATION FOR SEQ ID NO:1265: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1265: AUAACAAACU GAUGAGGCCG AAAGGCCGAA AAACCACA 38 INFORMATION FOR SEQ ID NO:1266: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single 323 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1266: GUGGUUUUUU UGUUAUU 17 INFORMATION FOR SEQ ID NO:1267: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1267: AAUAACAACU GAUGAGGCCG AAAGGCCGAA AAAACCAC 38 INFORMATION FOR SEQ ID NO:1268: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1268: UGGUUUUUUU GUUAUUG 17 INFORMATION FOR SEQ ID NO:1269: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1269: S CAAUAACACU GAUGAGGCCG AAAGGCCGAA AAAAACCA 38 INFORMATION FOR SEQ ID NO:1270: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1270: GGUUUUUUUG UUAUUGU 17 INFORMATION FOR SEQ ID NO:1271: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1271: ACAAUAACCU GAUGAGGCCG AAAGGCCGAA AAAAAACC 38 INFORMATION FOR SEQ ID NO:1272: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1272: UUUUUUGUUA UUGUUGG 17 INFORMATION FOR SEQ ID NO:1273: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1273: CCAACAAUCU GAUGAGGCCG AAAGGCCGAA ACAAAAAA 38 INFORMATION FOR SEQ ID NO:1274: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1274: UUUUUGUUAU UGUUGGU 17 INFORMATION FOR SEQ ID NO:1275: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1275: ACCAACAACU GAUGAGGCCG AAAGGCCGAA AACAAAAA 38 INFORMATION FOR SEQ ID NO:1276: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1276: UUUGUUAUUG UUGGUUU 17 INFORMATION FOR SEQ ID NO:1277: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1277: AAACCAACCU GAUGAGGCCG AAAGGCCGAA AUAACAAA 38 INFORMATION FOR SEQ ID NO:1278: 325 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1278: GUUAUUGUUG GUUUAUA 17 INFORMATION FOR SEQ ID NO:1279: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1279: UAUAAACCCU GAUGAGGCCG AAAGGCCGAA ACAAUAAC 38 *.t INFORMATION FOR SEQ ID NO:1280: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1280: UUGUUGGUUU AUACAAG 17 S* INFORMATION FOR SEQ ID NO:1281: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs *.OP TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1281: CUUGUAUACU GAUGAGGCCG AAAGGCCGAA ACCAACAA 38 INFORMATION FOR SEQ ID NO:1282: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1282: UGUUGGUUUA UACAAGC 17 INFORMATION FOR SEQ ID NO:1283: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1283: GCUUGUAUCU GAUGAGGCCG AAAGGCCGAA AACCAACA An 3z2G INFORMATION FOR SEQ ID NO:1284: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1284: GUUGGUUUAU ACAAGCA 17 INFORMATION FOR SEQ ID NO:1285: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1285: UGCUUGUACU GAUGAGGCCG AAAGGCCGAA AAACCAAC 38 INFORMATION FOR SEQ ID NO:1286: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1286: UGGUUUAUAC AAGCAUG 17 INFORMATION FOR SEQ ID NO:1287: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1287: .CAUGCUUGCU GAUGAGGCCG AAAGGCCGAA AUAAACCA 38 INFORMATION FOR SEQ ID NO:1288: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1288: GCAUGCGUUG CACUUCU 17 INFORMATION FOR SEQ ID NO:1289: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1289: 327 AGAAGUGCCU GAUGAGGCCG AAAGGCCGAA ACGCAUGC 38 INFORMATION FOR SEQ ID NO:1290: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1290: GUUGCACUUC UUUUUUG 17 INFORMATION FOR SEQ ID NO:1291: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1291: CAAAAAAGCU GAUGAGGCCG AAAGGCCGAA AGUGCAAC 38 INFORMATION FOR SEQ ID NO:1292: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1292: UUGCACUUCU UUUUUGG 17 INFORMATION FOR SEQ ID NO:1293: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1293: CCAAAAAACU GAUGAGGCCG AAAGGCCGAA AAGUGCAA 38 INFORMATION FOR SEQ ID NO:1294: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1294: GCACUUCUUU UUUGGGA 17 INFORMATION FOR SEQ ID NO:1295: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 32 3 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1295: UCCCAAAACU GAUGAGGCCG AAAGGCCGAA AGAAGUGC 38 INFORMATION FOR SEQ ID NO:1296: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1296: CACUUCUUUU UUGGGAG 17 INFORMATION FOR SEQ ID NO:1297: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1297: CUCCCAAACU GAUGAGGCCG AAAGGCCGAA AAGAAGUG 38 INFORMATION FOR SEQ ID NO:1298: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1298: ACUUCUUUUU UGGGAGA 17 INFORMATION FOR SEQ ID NO:1299: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S* TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1299: UCUCCCAACU GAUGAGGCCG AAAGGCCGAA AAAGAAGU 38 INFORMATION FOR SEQ ID NO:1300: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1300: CUUCUUUUUU GGGAGAU 17 INFORMATION FOR SEQ ID NO:1301: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1301: AUCUCCCACU GAUGAGGCCG AAAGGCCGAA AAAAGAAG 38 INFORMATION FOR SEQ ID NO:1302: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1302: UUCUUUUUUG GGAGAUG 17 INFORMATION FOR SEQ ID NO:1303: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1303: CAUCUCCCCU GAUGAGGCCG AAAGGCCGAA AAAAAGAA 38 INFORMATION FOR SEQ ID NO:1304: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1304: AUGUGUGUUG UUGAUGU o, 17 INFORMATION FOR SEQ ID NO:1305: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1305: ACAUCAACCU GAUGAGGCCG AAAGGCCGAA ACACACAU 38 INFORMATION FOR SEQ ID NO:1306: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1306: UGUGUUGUUG AUGUUCU 17 INFORMATION FOR SEQ ID NO:1307: 330 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1307: AGAACAUCCU GAUGAGGCCG AAAGGCCGAA ACAACACA 38 INFORMATION FOR SEQ ID NO:1308: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1308: GUUGAUGUUC UAUGUUU 17 INFORMATION FOR SEQ ID NO:1309: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1309: AAACAUAGCU GAUGAGGCCG AAAGGCCGAA ACAUCAAC 38 INFORMATION FOR SEQ ID NO:1310: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1310: GAUGUUCUAU GUUUUGU 17 INFORMATION FOR SEQ ID NO:1311: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1311: ACAAAACACU GAUGAGGCCG AAAGGCCGAA AGAACAUC 38 INFORMATION FOR SEQ ID NO:1312: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1312: UUCUAUGUUU UGUUUUG 17 INFORMATION FOR SEQ ID NO:1313: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1313: CAAAACAACU GAUGAGGCCG AAAGGCCGAA ACAUAGAA 38 INFORMATION FOR SEQ ID NO:1314: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1314: UCUAUGUUUU GUUUUGA 17 INFORMATION FOR SEQ ID NO:1315: SEQUENCE CHARACTERISTICS: A) LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1315: UCAAAACACU GAUGAGGCCG AAAGGCCGAA AACAUAGA 38 INFORMATION FOR SEQ ID NO:1316: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1316: S: CUAUGUUUUG UUUUGAG 17 INFORMATION FOR SEQ ID NO:1317: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1317: CUCAAAACCU GAUGAGGCCG AAAGGCCGAA AAACAUAG 38 INFORMATION FOR SEQ ID NO:1318: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1318: UGUUUUGUUU UGAGUGU 17 33 2 INFORMATION FOR SEQ ID NO:1319: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1319: ACACUCAACU GAUGAGGCCG AAAGGCCGAA ACAAAACA 38 INFORMATION FOR SEQ ID NO:1320: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1320: SGUUUUGUUUU GAGUGUA 17 INFORMATION FOR SEQ ID NO:1321: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1321: UACACUCACU GAUGAGGCCG AAAGGCCGAA AACAAAAC 38 INFORMATION FOR SEQ ID NO:1322: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs g TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear a* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1322: UUUUGUUUG AGUGUAG 17 INFORMATION FOR SEQ ID NO:1323: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1323: CUACACUCCU GAUGAGGCCG AAAGGCCGAA AAACAAAA 38 INFORMATION FOR SEQ ID NO:1324: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1324: UUGAGUGUAG CCUGACU INFORMATION FOR SEQ ID NO:1325: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1325: AGUCAGGCCU GAUGAGGCCG AAAGGCCGAA ACACUCAA 38 INFORMATION FOR SEQ ID NO:1326: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1326: CUGACUGUUU UAUAA 17 17 INFORMATION FOR SEQ ID NO:1327: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1327: AAUUAUAACU GAUGAGGCCG AAAGGCCGAA ACAGUCAG 38 INFORMATION FOR SEQ ID NO:1328: f* SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1328: UGACUGUUUU AUAAUUU 17 INFORMATION FOR SEQ ID NO:1329: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1329: AAAUUAUACU GAUGAGGCCG AAAGGCCGAA AACAGUCA 38 INFORMATION FOR SEQ ID NO:1330: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear _1 334- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1330: GACUGUUUUA UAAUUUG 17 INFORMATION FOR SEQ ID NO:1331: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1331: CAAAUUAUCU GAUGAGGCCG AAAGGCCGAA AAACAGUC 38 INFORMATION FOR SEQ ID NO:1332: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1332: ACUGUUUUAU

AAUUUGG

17 INFORMATION FOR SEQ ID NO:1333: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1333: CCAAAUUACU GAUGAGGCCG AAAGGCCGAA AAAACAGU 38 INFORMATION FOR SEQ ID NO:1334: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1334: UGUUUUAUAA UUUGGGA 17 INFORMATION FOR SEQ ID NO:1335: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1335: UCCCAAAUCU GAUGAGGCCG AAAGGCCGAA AUAAAACA 38 INFORMATION FOR SEQ ID NO:1336: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single 33 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1336: UUUAUAAUUU GGGAGUU 17 INFORMATION FOR SEQ ID NO:1337: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1337: AACUCCCACU GAUGAGGCCG AAAGGCCGAA AUUAUAAA 38 INFORMATION FOR SEQ ID NO:1338: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1338: UUAUAAUUUG GGAGUUC 17 INFORMATION FOR SEQ ID NO:1339: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1339: GAACUCCCCU GAUGAGGCCG AAAGGCCGAA AAUUAUAA 38 INFORMATION FOR SEQ ID NO:1340: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1340: UUGGGAGUUC UGCAUUU 17 INFORMATION FOR SEQ ID NO:1341: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1341: AAAUGCAGCU GAUGAGGCCG AAAGGCCGAA ACUCCCAA 38 INFORMATION FOR SEQ ID NO:1342: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1342: UUCUGCAUUU GAUCCGC 17 INFORMATION FOR SEQ ID NO:1343: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1343: GCGGAUCACU GAUGAGGCCG AAAGGCCGAA AUGCAGAA 38 INFORMATION FOR SEQ ID NO:1344: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1344: UCUGCAUUUG AUCCGCA 17 INFORMATION FOR SEQ ID NO:1345: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1345: UGCGGAUCCU GAUGAGGCCG AAAGGCCGAA AAUGCAGA 38 INFORMATION FOR SEQ ID NO:1346: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1346: CAUUUGAUCC GCAUCCC 17 INFORMATION FOR SEQ ID NO:1347: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1347: GGGAUGCGCU GAUGAGGCCG AAAGGCCGAA AUCAAAUG 38 337 INFORMATION FOR SEQ ID NO:1348: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1348: AUCCGCAUCC CCUGUGG 17 INFORMATION FOR SEQ ID NO:1349: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1349: CCACAGGGCU GAUGAGGCCG AAAGGCCGAA AUGCGGAU 38 INFORMATION FOR SEQ ID NO:1350: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S. STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1350: CCUGUGGUUU CUAAGUG 17 INFORMATION FOR SEQ ID NO:1351: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1351: CACUUAGACU GAUGAGGCCG AAAGGCCGAA ACCACAGG 38 INFORMATION FOR SEQ ID NO:1352: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1352: CUGUGGUUUC UAAGUGU 17 INFORMATION FOR SEQ ID NO:1353: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1353: ACACUUAGCU GAUGAGGCCG AAAGGCCGAA AACCACAG 38 33t INFORMATION FOR SEQ ID NO:1354: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1354: UGUGGUUUCU AAGUGUA 17 INFORMATION FOR SEQ ID NO:1355: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1355: UACACUUACU GAUGAGGCCG AAAGGCCGAA AAACCACA 38 INFORMATION FOR SEQ ID NO:1356: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1356: UGGUUUCUAA GUGUAUG 17 INFORMATION FOR SEQ ID NO:1357: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear a (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1357: CAUACACUCU GAUGAGGCCG AAAGGCCGAA AGAAACCA 38 INFORMATION FOR SEQ ID NO:1358: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1358: CUAAGUGUAU GGUCUCA 17 INFORMATION FOR SEQ ID NO:1359: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1359: 339 S UGAGACCACU GAUGAGGCCG AAAGGCCGAA ACACUUAG 38 INFORMATION FOR SEQ ID NO:1360: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1360: UGUAUGGUCU CAGAACU 17 INFORMATION FOR SEQ ID NO:1361: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1361: AGUUCUGACU GAUGAGGCCG AAAGGCCGAA ACCAUACA 38 INFORMATION FOR SEQ ID NO:1362: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear f (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1362: UAUGGUCUCA GAACUGU 17 INFORMATION FOR SEQ ID NO:1363: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1363: ACAGUUCUCU GAUGAGGCCG AAAGGCCGAA AGACCAUA 38 INFORMATION FOR SEQ ID NO:1364: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1364: AGAACUGUUG CAUGGAU 17 INFORMATION FOR SEQ ID NO:1365: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 340 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1365: AUCCAUGCCU GAUGAGGCCG AAAGGCCGAA ACAGUUCU 38 INFORMATION FOR SEQ ID NO:1366: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1366: GCAUGGAUCC UGUGUUU 17 INFORMATION FOR SEQ ID NO:1367: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1367: AAACACAGCU GAUGAGGCCG AAAGGCCGAA AUCCAUGC 38 INFORMATION FOR SEQ ID NO:1368: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1368: UCCUGUGUUU GCAACUG 17 INFORMATION FOR SEQ ID NO:1369: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1369: CAGUUGCACU GAUGAGGCCG AAAGGCCGAA ACACAGGA 38 INFORMATION FOR SEQ ID NO:1370: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1370: CCUGUGUUUG CAACUGG 17 INFORMATION FOR SEQ ID NO:1371: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 34-1 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1371: CCAGUUGCCU GAUGAGGCCG AAAGGCCGAA AACACAGG 38 INFORMATION FOR SEQ ID NO:1372: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1372: ACUGUGGUUG AUAGCCA 17 INFORMATION FOR SEQ ID NO:1373: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1373: UGGCUAUCCU GAUGAGGCCG AAAGGCCGAA ACCACAGU 38 INFORMATION FOR SEQ ID NO:1374: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1374: UGGUUGAUAG CCAGUCA 17 INFORMATION FOR SEQ ID NO:1375: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1375: UGACUGGCCU GAUGAGGCCG AAAGGCCGAA AUCAACCA 38 INFORMATION FOR SEQ ID NO:1376: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1376: UAGCCAGUCA CUGCCUU 17 INFORMATION FOR SEQ ID NO:1377: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1377: AAGGCAGUCU GAUGAGGCCG AAAGGCCGAA ACUGGCUA 38 INFORMATION FOR SEQ ID NO:1378: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1378: CACUGCCUUA AGAACAU 17 INFORMATION FOR SEQ ID NO:1379: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1379: AUGUUCUUCU GAUGAGGCCG AAAGGCCGAA AGGCAGUG 38 INFORMATION FOR SEQ ID NO:1380: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1380: ACUGCCUUAA GAACAUU 17 INFORMATION FOR SEQ ID NO:1381: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1381: AAUGUUCUCU GAUGAGGCCG AAAGGCCGAA AAGGCAGU 38 INFORMATION FOR SEQ ID NO:1382: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1382: AAGAACAUUU GAUGCAA 17 INFORMATION FOR SEQ ID NO:1383: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1383: UUGCAUCACU GAUGAGGCCG AAAGGCCGAA AUGUUCUU 38 INFORMATION FOR SEQ ID NO:1384: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1384: AGAACAUUUG AUGCAAG 17 INFORMATION FOR SEQ ID NO:1385: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1385: CUUGCAUCCU GAUGAGGCCG AAAGGCCGAA AAUGUUCU 38 INFORMATION FOR SEQ ID NO:1386: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1386: S ACUGAACUUU UGAGAUA 17 INFORMATION FOR SEQ ID NO:1387: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1387: UAUCUCAACU GAUGAGGCCG AAAGGCCGAA AGUUCAGU 38 INFORMATION FOR SEQ ID NO:1388: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1388: CUGAACUUUU GAGAUAU 34-4- INFORMATION FOR SEQ ID NO:1389: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1389: AUAUCUCACU GAUGAGGCCG AAAGGCCGAA AAGUUCAG 38 INFORMATION FOR SEQ ID NO:1390: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1390: UGAACUUUUG AGAUAUG 17 INFORMATION FOR SEQ ID NO:1391: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1391: CAUAUCUCCU GAUGAGGCCG AAAGGCCGAA AAAGUUCA 38 INFORMATION FOR SEQ ID NO:1392: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1392: UUUGAGAUAU GACGGUG 17 INFORMATION FOR SEQ ID NO:1393: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1393: CACCGUCACU GAUGAGGCCG AAAGGCCGAA AUCUCAAA 38 INFORMATION FOR SEQ ID NO:1394: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1394: GACGGUGUAC UUACUGC 17 INFORMATION FOR SEQ ID NO:1395: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1395: GCAGUAAGCU GAUGAGGCCG AAAGGCCGAA ACACCGUC 38 INFORMATION FOR SEQ ID NO:1396: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1396: GGUGUACUUA CUGCCUU 17 INFORMATION FOR SEQ ID NO:1397: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1397: AAGGCAGUCU GAUGAGGCCG AAAGGCCGAA AGUACACC 38 INFORMATION FOR SEQ ID NO:1398: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1398: GUGUACUUAC UGCCUUG 17 INFORMATION FOR SEQ ID NO:1399: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1399: CAAGGCAGCU GAUGAGGCCG AAAGGCCGAA AAGUACAC 38 INFORMATION FOR SEQ ID NO:1400: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1400: UACUGCCUUG UAGCAAA 17 INFORMATION FOR SEQ ID NO:1401: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1401: UUUGCUACCU GAUGAGGCCG AAAGGCCGAA AGGCAGUA 38 INFORMATION FOR SEQ ID NO:1402: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1402: UGCCUUGUAG CAAAAUA 17 INFORMATION FOR SEQ ID NO:1403: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1403: UAUUUUGCCU GAUGAGGCCG AAAGGCCGAA ACAAGGCA 38 INFORMATION FOR SEQ ID NO:1404: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1404: AGCAAAAUAA AGAUGUG 17 INFORMATION FOR SEQ ID NO:1405: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1405: CACAUCUUCU GAUGAGGCCG AAAGGCCGAA AUUUUGCU 38 INFORMATION FOR SEQ ID NO:1406: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1406: UGUGCCCUUA UUUUACC 17 INFORMATION FOR SEQ ID NO:1407: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1407: GGUAAAAUCU GAUGAGGCCG AAAGGCCGAA AGGGCACA 38 INFORMATION FOR SEQ ID NO:1408: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1408: o GUGCCCUUAU UUUACCU 17 INFORMATION FOR SEQ ID NO:1409: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1409: AGGUAAAACU GAUGAGGCCG AAAGGCCGAA AAGGGCAC 38 INFORMATION FOR SEQ ID NO:1410: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1410: CCGGGGCUCU UGGCGGA 17 INFORMATION FOR SEQ ID NO:1411: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1411: UCCGCCAACU GAUGAGGCCG AAAGGCCGAA AGCCCCGG 38 INFORMATION FOR SEQ ID NO:1412: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1412: GGGGCUCUUG GCGGAGC 17 INFORMATION FOR SEQ ID NO:1413: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1413: GCUCCGCCCU GAUGAGGCCG AAAGGCCGAA AGAGCCCC 38 INFORMATION FOR SEQ ID NO:1414: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S" TOPOLOGY: linear e (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1414: GCCCGCCUCG CCAUGGC 17 INFORMATION FOR SEQ ID NO:1415: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1415: GCCAUGGCCU GAUGAGGCCG AAAGGCCGAA AGGCGGGC 38 9 INFORMATION FOR SEQ ID NO:1416: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1416: CACAGCAUCU ACAGUAG 17 INFORMATION FOR SEQ ID NO:1417: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1417: CUACUGUACU GAUGAGGCCG AAAGGCCGAA AUGCUGUG 38 INFORMATION FOR SEQ ID NO:1418: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1418: CAGCAUCUAC AGUAGCG 17 INFORMATION FOR SEQ ID NO:1419: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1419: CGCUACUGCU GAUGAGGCCG AAAGGCCGAA AGAUGCUG 38 INFORMATION FOR SEQ ID NO:1420: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1420: UCUACAGUAG CGAUGAA 17 INFORMATION FOR SEQ ID NO:1421: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1421: UUCAUCGCCU GAUGAGGCCG AAAGGCCGAA ACUGUAGA 38 9 INFORMATION FOR SEQ ID NO:1422: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1422: GAAGACAUUG AGAUGUG 17 INFORMATION FOR SEQ ID NO:1423: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1423: CACAUCUCCU GAUGAGGCCG AAAGGCCGAA AUGUCUUC

IQ

350 INFORMATION FOR SEQ ID NO:1424: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1424: CCAUGACUAC GAUGGGC 17 INFORMATION FOR SEQ ID NO:1425: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1425: S GCCCAUCGCU GAUGAGGCCG AAAGGCCGAA AGUCAUGG 38 INFORMATION FOR SEQ ID NO:1426: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1426: GCCCAAAUCU GGAAAGC 17 INFORMATION FOR SEQ ID NO:1427: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1427: GCUUUCCACU GAUGAGGCCG AAAGGCCGAA AUUUGGGC 38 INFORMATION FOR SEQ ID NO:1428: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1428: GAAAGCGUCA CUUGGGG 17 INFORMATION FOR SEQ ID NO:1429: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1429: CCCCAAGUCU GAUGAGGCCG AAAGGCCGAA ACGCUUUC 38 INFORMATION FOR SEQ ID NO:1430: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1430: GCGUCACUUG GGGAAAA 17 INFORMATION FOR SEQ ID NO:1431: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1431: .**UUUUCCCCCU GAUGAGGCCG AAAGGCCGAA AGUGACGC 38 INFORMATION FOR SEQ ID NO:1432: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1432: GGAAAACUAG GUGGACA 17 INFORMATION FOR SEQ ID NO:1433: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1433: UGUCCACCCU GAUGAGGCCG AAAGGCCGAA AGUUUUCC 38 INFORMATION FOR SEQ ID NO:1434: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1434: UGGAAAGUCA UUGCCAA 17 INFORMATION FOR SEQ ID NO:1435: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 352 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1435: UUGGCAAUCU GAUGAGGCCG AAAGGCCGAA ACUUUCCA 38 INFORMATION FOR SEQ ID NO:1436: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1436: AAAGUCAUUG CCAAUUA 17 INFORMATION FOR SEQ ID NO:1437: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1437: UAAUUGGCCU GAUGAGGCCG AAAGGCCGAA AUGACUUU 38 S. INFORMATION FOR SEQ ID NO:1438: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1438: UUGCCAAUUA UCUGCCC 17 INFORMATION FOR SEQ ID NO:1439: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1439: GGGCAGAUCU GAUGAGGCCG AAAGGCCGAA AUUGGCAA 38 INFORMATION FOR SEQ ID NO:1440: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1440: UGCCAAUUAU CUGCCCA 17 INFORMATION FOR SEQ ID NO:1441: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1441: UGGGCAGACU GAUGAGGCCG AAAGGCCGAA AAUUGGCA 38 INFORMATION FOR SEQ ID NO:1442: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1442: CCAAUUAUCU GCCCAAC 17 INFORMATION FOR SEQ ID NO:1443: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1443: GUUGGGCACU GAUGAGGCCG AAAGGCCGAA AUAAUUGG 38 S9 INFORMATION FOR SEQ ID NO:1444: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1444: S ACAGAUGUAC AGUGCCA 17 INFORMATION FOR SEQ ID NO:1445: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1445: UGGCACUGCU GAUGAGGCCG AAAGGCCGAA ACAUCUGU 38 INFORMATION FOR SEQ ID NO:1446: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1446: CCUGAACUCA UCAAAGG 17 INFORMATION FOR SEQ ID N0:1447: SEQUENCE CHARACTERISTICS: 354- LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1447: CCUUUGAUCU GAUGAGGCCG AAAGGCCGAA AGUUCAGG 38 INFORMATION FOR SEQ ID NO:1448: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1448: GAACUCAUCA AAGGUCC 17 INFORMATION FOR SEQ ID NO:1449: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1449: GGACCUUUCU GAUGAGGCCG AAAGGCCGAA AUGAGUUC 38 INFORMATION FOR SEQ ID NO:1450: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1450: UCAAAGGUCC

CUGGACC

17 INFORMATION FOR SEQ ID NO:1451: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1451: GGUCCAGGCU GAUGAGGCCG AAAGGCCGAA ACCUUUGA 38 INFORMATION FOR SEQ ID NO:1452: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1452: AAGAAGAUCA GAGAGUC INFORMATION FOR SEQ ID NO:1453: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1453: GACUCUCUCU GAUGAGGCCG AAAGGCCGAA AUCUUCUU 38 INFORMATION FOR SEQ ID NO:1454: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1454: CAGAGAGUCA UAAAGCU 17 INFORMATION FOR SEQ ID NO:1455: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1455: AGCUUUAUCU GAUGAGGCCG AAAGGCCGAA ACUCUCUG 38 INFORMATION FOR SEQ ID N0:1456: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1456: o AGAGUCAUAA

AGCUUGU

17 INFORMATION FOR SEQ ID NO:1457: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1457: ACAAGCUUCU GAUGAGGCCG AAAGGCCGAA AUGACUCU 38 INFORMATION FOR SEQ ID NO:1458: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1458: AUAAAGCUUG UCCAGAA INFORMATION FOR SEQ ID NO:1459: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1459: UUCUGGACCU GAUGAGGCCG AAAGGCCGAA AGCUUUAU 38 INFORMATION FOR SEQ ID NO:1460: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1460: AAGCUUGUCC AGAAAUA 17 INFORMATION FOR SEQ ID NO:1461: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1461: UAUUUCUGCU GAUGAGGCCG AAAGGCCGAA ACAAGCUU 38 INFORMATION FOR SEQ ID NO:1462: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1462: CCAGAAAUAU GGUCCGA 17 INFORMATION FOR SEQ ID NO:1463: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1463: UCGGACCACU GAUGAGGCCG AAAGGCCGAA AUUUCUGG 38 INFORMATION FOR SEQ ID NO:1464: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1464: 3^n7 AAUAUGGUCC GAAGCGU 17 INFORMATION FOR SEQ ID NO:1465: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1465: ACGCUUCGCU GAUGAGGCCG AAAGGCCGAA ACCAUAUU 38 INFORMATION FOR SEQ ID NO:1466: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1466: CGAAGCGUUG GUCUGUU 17 INFORMATION FOR SEQ ID NO:1467: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1467: AACAGACCCU GAUGAGGCCG AAAGGCCGAA ACGCUUCG 38 INFORMATION FOR SEQ ID NO:1468: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1468: GCGUUGGUCU GUUAUUG 17 INFORMATION FOR SEQ ID NO:1469: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1469: CAAUAACACU GAUGAGGCCG AAAGGCCGAA ACCAACGC 38 INFORMATION FOR SEQ ID NO:1470: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1470: UGGUCUGUUA UUGCCAA 17 INFORMATION FOR SEQ ID NO:1471: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1471: UUGGCAAUCU GAUGAGGCCG AAAGGCCGAA ACAGACCA 38 INFORMATION FOR SEQ ID NO:1472: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1472: GGUCUGUUAU UGCCAAG 17 INFORMATION FOR SEQ ID NO:1473: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1473: CUUGGCAACU GAUGAGGCCG AAAGGCCGAA AACAGACC 38 INFORMATION FOR SEQ ID N0:1474: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1474: UCUGUUAUUG CCAAGCA 17 INFORMATION FOR SEQ ID NO:1475: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1475: UGCUUGGCCU GAUGAGGCCG AAAGGCCGAA AUAACAGA 38 INFORMATION FOR SEQ ID NO:1476: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1476: CAAGCACUUA AAAGGGA 17 INFORMATION FOR SEQ ID NO:1477: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1477: UCCCUUUUCU GAUGAGGCCG AAAGGCCGAA AGUGCUUG 38 INFORMATION FOR SEQ ID NO:1478: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1478: AAGCACUUAA AAGGGAG 17 INFORMATION FOR SEQ ID NO:1479: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1479: CUCCCUUUCU GAUGAGGCCG AAAGGCCGAA AAGUGCUU 38 INFORMATION FOR SEQ ID NO:1480: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1480: GGGAGAAUUG GAAAGCA 17 INFORMATION FOR SEQ ID NO:1481: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1481: UGCUUUCCCU GAUGAGGCCG AAAGGCCGAA AUUCUCCC 38 INFORMATION FOR SEQ ID NO:1482: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1482: AGCAGUGUCG GGAGAGG 17 INFORMATION FOR SEQ ID NO:1483: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1483: CCUCUCCCCU GAUGAGGCCG AAAGGCCGAA ACACUGCU 38 INFORMATION FOR SEQ ID NO:1484: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1484: ACAACCAUUU GAAUCCA 17 INFORMATION FOR SEQ ID NO:1485: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1485: UGGAUUCACU GAUGAGGCCG AAAGGCCGAA AUGGUUGU 38 INFORMATION FOR SEQ ID NO:1486: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1486: CAACCAUUUG AAUCCAG 17 INFORMATION FOR SEQ ID NO:1487: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1487: CUGGAUUCCU GAUGAGGCCG AAAGGCCGAA AAUGGUUG 38 INFORMATION FOR SEQ ID NO:1488: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1488: AUUUGAAUCC AGAAGUU 17 INFORMATION FOR SEQ ID NO:1489: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1489: AACUUCUGCU GAUGAGGCCG AAAGGCCGAA AUUCAAAU 38 INFORMATION FOR SEQ ID NO:1490: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1490: CCAGAAGUUA AGAAAAC S. INFORMATION FOR SEQ ID NO:1491: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1491: GUUUUCUUCU GAUGAGGCCG AAAGGCCGAA ACUUCUGG 38 INFORMATION FOR SEQ ID NO:1492: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1492: CAGAAGUUAA

GAAAACC

17 INFORMATION FOR SEQ ID NO:1493: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1493: GGUUUUCUCU GAUGAGGCCG AAAGGCCGAA AACUUCUG o0 INFORMATION FOR SEQ ID NO:1494: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1494: GAAAACCUCC UGGACAG 17 INFORMATION FOR SEQ ID NO:1495: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1495: CUGUCCAGCU GAUGAGGCCG AAAGGCCGAA AGGUUUUC 38 o INFORMATION FOR SEQ ID NO:1496: SEQUENCE CHARACTERISTICS: S• LENGTH: 17 base pairs TYPE: nucleic acid S* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1496: GACAGAAUCA UUUACCA 17 INFORMATION FOR SEQ ID NO:1497: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1497: UGGUAAAUCU GAUGAGGCCG AAAGGCCGAA AUUCUGUC 38 INFORMATION FOR SEQ ID NO:1498: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1498: AGAAUCAUUU ACCAGGC 17 INFORMATION FOR SEQ ID NO:1499: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1499: GCCUGGUACU GAUGAGGCCG AAAGGCCGAA AUGAUUCU 38 INFORMATION FOR SEQ ID NO:1500: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1500: GAAUCAUUUA CCAGGCA 17 INFORMATION FOR SEQ ID NO:1501: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1501: UGCCUGGUCU GAUGAGGCCG AAAGGCCGAA AAUGAUUC 38 INFORMATION FOR SEQ ID NO:1502: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1502: AAUCAUUUAC CAGGCAC 17 INFORMATION FOR SEQ ID NO:1503: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1503: GUGCCUGGCU GAUGAGGCCG AAAGGCCGAA AAAUGAUU 38 INFORMATION FOR SEQ ID NO:1504: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1504: ACAAGCGUCU GGGGAAC 17 INFORMATION FOR SEQ ID NO:1505: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 3 4 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1505: GUUCCCCACU GAUGAGGCCG AAAGGCCGAA ACGCUUGU 38 INFORMATION FOR SEQ ID NO:1506: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1506: GCAGAGAUCG CAAAGCU 17 INFORMATION FOR SEQ ID NO:1507: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1507: AGCUUUGCCU GAUGAGGCCG AAAGGCCGAA AUCUCUGC 38 INFORMATION FOR SEQ ID NO:1508: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1508: GGACUGAUAA UGCUAUC 17 INFORMATION FOR SEQ ID NO:1509: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1509: GAUAGCAUCU GAUGAGGCCG AAAGGCCGAA AUCAGUCC 38 INFORMATION FOR SEQ ID NO:1510: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1510: AUAAUGCUAU CAAGAAC 17 INFORMATION FOR SEQ ID NO:1511: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1511: GUUCUUGACU GAUGAGGCCG AAAGGCCGAA AGCAUUAU 38 INFORMATION FOR SEQ ID NO:1512: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1512: AAUGCUAUCA AGAACCA 17 INFORMATION FOR SEQ ID NO:1513: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear So. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1513: S UGGUUCUUCU GAUGAGGCCG AAAGGCCGAA AUAGCAUU 38 INFORMATION FOR SEQ ID NO:1514: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1514: ACUGGAAUUC CACCAUG 17 INFORMATION FOR SEQ ID NO:1515: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1515: CAUGGUGGCU GAUGAGGCCG AAAGGCCGAA AUUCCAGU 38 INFORMATION FOR SEQ ID NO:1516: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1516: CUGGAAUUCC ACCAUGC 17 INFORMATION FOR SEQ ID NO:1517: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1517: GCAUGGUGCU GAUGAGGCCG AAAGGCCGAA AAUUCCAG 38 INFORMATION FOR SEQ ID NO:1518: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1518: CCAUGCGUCG CAAGGUG 17 INFORMATION FOR SEQ ID NO:1519: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1519: CACCUUGCCU GAUGAGGCCG AAAGGCCGAA ACGCAUGG 38 INFORMATION FOR SEQ ID NO:1520: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1520: GGAAGGCUAC CUGCAGA 17 INFORMATION FOR SEQ ID NO:1521: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1521: UCUGCAGGCU GAUGAGGCCG AAAGGCCGAA AGCCUUCC 38 INFORMATION FOR SEQ ID NO:1522: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1522: AGAAGCCUUC CAAAGCC 17 INFORMATION FOR SEQ ID NO:1523: 36 7 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1523: GGCUUUGGCU GAUGAGGCCG AAAGGCCGAA AGGCUUCU 38 INFORMATION FOR SEQ ID NO:1524: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1524: GAAGCCUUCC AAAGCCA 17 INFORMATION FOR SEQ ID NO:1525: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1525: UGGCUUUGCU GAUGAGGCCG AAAGGCCGAA AAGGCUUC 38 INFORMATION FOR SEQ ID NO:1526: 4* SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1526: CACGAGCUUC CAGAAGA •17 INFORMATION FOR SEQ ID NO:1527: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1527: UCUUCUGGCU GAUGAGGCCG AAAGGCCGAA AGCUCGUG 38 INFORMATION FOR SEQ ID NO:1528: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1528: ACGAGCUUCC AGAAGAA INFORMATION FOR SEQ ID NO:1529: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1529: UUCUUCUGCU GAUGAGGCCG AAAGGCCGAA AAGCUCGU 38 INFORMATION FOR SEQ ID NO:1530: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1530: AGAACAAUCA UUUGAUG 17 INFORMATION FOR SEQ ID NO:1531: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1531: CAUCAAAUCU GAUGAGGCCG AAAGGCCGAA AUUGUUCU 38 INFORMATION FOR SEQ ID NO:1532: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1532: ACAAUCAUUU GAUGGGG 17 INFORMATION FOR SEQ ID NO:1533: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1533: CCCCAUCACU GAUGAGGCCG AAAGGCCGAA AUGAUUGU 38 INFORMATION FOR SEQ ID NO:1534: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1534: S CAAUCAUUUG AUGGGGU 17 INFORMATION FOR SEQ ID NO:1535: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1535: ACCCCAUCCU GAUGAGGCCG AAAGGCCGAA AAUGAUUG 38 INFORMATION FOR SEQ ID NO:1536: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1536: GAUGGGGUUU GGGCAUG 17 INFORMATION FOR SEQ ID NO:1537: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1537: CAUGCCCACU GAUGAGGCCG AAAGGCCGAA ACCCCAUC 38 INFORMATION FOR SEQ ID NO:1538: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1538: AUGGGGUUUG GGCAUGC INFORMATION FOR SEQ ID NO:1539: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1539: GCAUGCCCCU GAUGAGGCCG AAAGGCCGAA AACCCCAU 38 INFORMATION FOR SEQ ID NO:1540: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 3'70 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1540: GCAUGCCUCA CCUCCAU 17 INFORMATION FOR SEQ ID NO:1541: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1541: AUGGAGGUCU GAUGAGGCCG AAAGGCCGAA AGGCAUGC 38 INFORMATION FOR SEQ ID NO:1542: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1542: S* CCUCACCUCC AUCUCAG 17 INFORMATION FOR SEQ ID NO:1543: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1543: CUGAGAUGCU GAUGAGGCCG AAAGGCCGAA AGGUGAGG 38 INFORMATION FOR SEQ ID NO:1544: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear o (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1544: ACCUCCAUCU CAGCUCU 17 INFORMATION FOR SEQ ID NO:1545: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1545: AGAGCUGACU GAUGAGGCCG AAAGGCCGAA AUGGAGGU 38 INFORMATION FOR SEQ ID NO:1546: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single 37 i TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1546: CUCCAUCUCA GCUCUCU 17 INFORMATION FOR SEQ ID NO:1547: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1547: AGAGAGCUCU GAUGAGGCCG AAAGGCCGAA AGAUGGAG 38 INFORMATION FOR SEQ ID NO:1548: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1548: UCUCAGCUCU CUCCAAG 17 INFORMATION FOR SEQ ID NO:1549: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1549: CUUGGAGACU GAUGAGGCCG AAAGGCCGAA AGCUGAGA 38 INFORMATION FOR SEQ ID NO:1550: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1550: UCAGCUCUCU CCAAGUG 17 INFORMATION FOR SEQ ID NO:1551: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1551: CACUUGGACU GAUGAGGCCG AAAGGCCGAA AGAGCUGA 38 INFORMATION FOR SEQ ID NO:1552: SEQUENCE CHARACTERISTICS: 3-72 LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1552: AGCUCUCUCC AAGUGGC 17 INFORMATION FOR SEQ ID NO:1553: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1553: GCCACUUGCU GAUGAGGCCG AAAGGCCGAA AGAGAGCU 38 INFORMATION FOR SEQ ID NO:1554: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1554: UGGCCAGUCC UCCGUCA 17 INFORMATION FOR SEQ ID NO:1555: S: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1555: UGACGGAGCU GAUGAGGCCG AAAGGCCGAA ACUGGCCA 38 INFORMATION FOR SEQ ID NO:1556: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1556: CCAGUCCUCC GUCAACA 17 INFORMATION FOR SEQ ID NO:1557: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1557: UGUUGACGCU GAUGAGGCCG AAAGGCCGAA AGGACUGG 1A 3-7 3 INFORMATION FOR SEQ ID NO:1558: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1558: UCCUCCGUCA ACAGCGA 17 INFORMATION FOR SEQ ID NO:1559: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1559: UCGCUGUUCU GAUGAGGCCG AAAGGCCGAA ACGGAGGA 38 INFORMATION FOR SEQ ID NO:1560: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1560: CAGCGAAUAU CCCUAUU 17 INFORMATION FOR SEQ ID NO:1561: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1561: AAUAGGGACU GAUGAGGCCG AAAGGCCGAA AUUCGCUG 38 INFORMATION FOR SEQ ID NO:1562: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1562: GCGAAUAUCC CUAUUAC 17 INFORMATION FOR SEQ ID NO:1563: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1563: GUAAUAGGCU GAUGAGGCCG AAAGGCCGAA AUAUUCGC 3-7 4- INFORMATION FOR SEQ ID NO:1564: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1564: AUAUCCCUAU UACCACA 17 INFORMATION FOR SEQ ID NO:1565: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1565: UGUGGUAACU GAUGAGGCCG AAAGGCCGAA AGGGAUAU 38 INFORMATION FOR SEQ ID NO:1566: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1566: AUCCCUAUUA CCACAUC 17 17 INFORMATION FOR SEQ ID NO:1567: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1567: SGAUGUGGUCU GAUGAGGCCG AAAGGCCGAA AUAGGGAU 38 INFORMATION FOR SEQ ID NO:1568: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1568: UCCCUAUUAC CACAUCG 17 INFORMATION FOR SEQ ID NO:1569: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1569: ,375 CGAUGUGGCU GAUGAGGCCG AAAGGCCGAA AAUAGGGA 38 INFORMATION FOR SEQ ID NO:1570: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1570: UACCACAUCG CCGAAGC 17 INFORMATION FOR SEQ ID NO:1571: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1571: GCUUCGGCCU GAUGAGGCCG AAAGGCCGAA AUGUGGUA 38 INFORMATION FOR SEQ ID NO:1572: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S. TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1572: CAAAACAUCU CCAGUCA 17 t o INFORMATION FOR SEQ ID NO:1573: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1573: UGACUGGACU GAUGAGGCCG AAAGGCCGAA AUGUUUUG 38 INFORMATION FOR SEQ ID NO:1574: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1574: AAACAUCUCC AGUCACG 17 INFORMATION FOR SEQ ID NO:1575: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1575: CGUGACUGCU GAUGAGGCCG AAAGGCCGAA AGAUGUUU 38 INFORMATION FOR SEQ ID NO:1576: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1576: UCUCCAGUCA CGUUCCC 17 INFORMATION FOR SEQ ID NO:1577: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1577: GGGAACGUCU GAUGAGGCCG AAAGGCCGAA ACUGGAGA 38 I. INFORMATION FOR SEQ ID NO:1578: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S0 TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1578: AGUCACGUUC CCUAUCC 17 INFORMATION FOR SEQ ID N0:1579: SEQUENCE CHARACTERISTICS: *0 LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S* TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1579: GGAUAGGGCU GAUGAGGCCG AAAGGCCGAA ACGUGACU 38 INFORMATION FOR SEQ ID NO:1580: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1580: GUCACGUUCC CUAUCCU 17 INFORMATION FOR SEQ ID NO:1581: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 377 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1581: AGGAUAGGCU GAUGAGGCCG AAAGGCCGAA AACGUGAC 38 INFORMATION FOR SEQ ID NO:1582: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1582: CGUUCCCUAU CCUGUCG 17 INFORMATION FOR SEQ ID NO:1583: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1583: CGACAGGACU GAUGAGGCCG AAAGGCCGAA AGGGAACG 38 INFORMATION FOR SEQ ID NO:1584: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1584: UUCCCUAUCC UGUCGCA 17 17 INFORMATION FOR SEQ ID NO:1585: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1585: UGCGACAGCU GAUGAGGCCG AAAGGCCGAA AUAGGGAA 38 INFORMATION FOR SEQ ID NO:1586: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1586: UAUCCUGUCG CAUUGCA 17 INFORMATION FOR SEQ ID NO:1587: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs 3-7 TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1587: UGCAAUGCCU GAUGAGGCCG AAAGGCCGAA ACAGGAUA 38 INFORMATION FOR SEQ ID NO:1588: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1588: UGUCGCAUUG

CAUGUUA

17 INFORMATION FOR SEQ ID NO:1589: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1589: UAACAUGCCU GAUGAGGCCG AAAGGCCGAA

AUGCGACA

38 INFORMATION FOR SEQ ID NO:1590: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1590: UUGCAUGUUA AUAUAGU 17 17 9(2) INFORMATION FOR SEQ ID NO:1591: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1591: ACUAUAUUCU GAUGAGGCCG AAAGGCCGAA ACAUGCAA 38 INFORMATION FOR SEQ ID NO:1592: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1592: UGCAUGUUAA

UAUAGUC

17 INFORMATION FOR SEQ ID NO:1593: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1593: GACUAUAUCU GAUGAGGCCG AAAGGCCGAA AACAUGCA 38 INFORMATION FOR SEQ ID NO:1594: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1594: AUGUUAAUAU AGUCAAC 17 INFORMATION FOR SEQ ID NO:1595: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1595: GUUGACUACU GAUGAGGCCG AAAGGCCGAA AUUAACAU 38 INFORMATION FOR SEQ ID NO:1596: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1596: GUUAAUAUAG UCAACGU 17 INFORMATION FOR SEQ ID NO:1597: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1597: ACGUUGACCU GAUGAGGCCG AAAGGCCGAA AUAUUAAC 38 INFORMATION FOR SEQ ID NO:1598: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1598: AAUAUAGUCA ACGUCCC INFORMATION FOR SEQ ID NO:1599: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1599: GGGACGUUCU GAUGAGGCCG AAAGGCCGAA ACUAUAUU 38 INFORMATION FOR SEQ ID NO:1600: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1600: GUCAACGUCC CUCAGCC 17 INFORMATION FOR SEQ ID NO:1601: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1601: GGCUGAGGCU GAUGAGGCCG AAAGGCCGAA ACGUUGAC 38 INFORMATION FOR SEQ ID NO:1602: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1602: ACGUCCCUCA GCCGGCU 17 INFORMATION FOR SEQ ID NO:1603: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1603: AGCCGGCUCU GAUGAGGCCG AAAGGCCGAA AGGGACGU 38 INFORMATION FOR SEQ ID NO:1604: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1604: GCAGCCAUCC AGAGACA 17 INFORMATION FOR SEQ ID NO:1605: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1605: UGUCUCUGCU GAUGAGGCCG AAAGGCCGAA AUGGCUGC 38 INFORMATION FOR SEQ ID NO:1606: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1606: GAGACACUAU AACGACG 17 INFORMATION FOR SEQ ID NO:1607: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1607: CGUCGUUACU GAUGAGGCCG AAAGGCCGAA AGUGUCUC 38 S° INFORMATION FOR SEQ ID NO:1608: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1608: GACACUAUAA CGACGAA 17 INFORMATION FOR SEQ ID NO:1609: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1609: UUCGUCGUCU GAUGAGGCCG AAAGGCCGAA AUAGUGUC 38 INFORMATION FOR SEQ ID NO:1610: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1610: AAGCGAAUAA AGGAGCU 17 INFORMATION FOR SEQ ID NO:1611: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1611: AGCUCCUUCU GAUGAGGCCG AAAGGCCGAA AUUCGCUU 38 INFORMATION FOR SEQ ID NO:1612: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear o (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1612: GCUGGAGUUG

CUCCUGA

17 INFORMATION FOR SEQ ID NO:1613: o o SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1613: UCAGGAGCCU GAUGAGGCCG AAAGGCCGAA ACUCCAGC 38 INFORMATION FOR SEQ ID NO:1614: •c SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1614: GAGUUGCUCC

UGAUGUC

17 INFORMATION FOR SEQ ID NO:1615: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1615: GACAUCAGCU GAUGAGGCCG AAAGGCCGAA AGCAACUC 38 INFORMATION FOR SEQ ID NO:1616: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1616: CCUGAUGUCA ACAGAGA 17 INFORMATION FOR SEQ ID NO:1617: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1617: UCUCUGUUCU GAUGAGGCCG AAAGGCCGAA ACAUCAGG 38 INFORMATION FOR SEQ ID NO:1618: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1618: SGCAGGCAUUA CCAACAC 17 INFORMATION FOR SEQ ID NO:1619: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1619: GUGUUGGUCU GAUGAGGCCG AAAGGCCGAA AUGCCUGC 38 INFORMATION FOR SEQ ID NO:1620: o SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1620: CAGGCAUUAC CAACACA 17 INFORMATION FOR SEQ ID NO:1621: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1621: UGUGUUGGCU GAUGAGGCCG AAAGGCCGAA AAUGCCUG 38 INFORMATION FOR SEQ ID NO:1622: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1622: ACCACACUUG CAGCUAC 17 INFORMATION FOR SEQ ID NO:1623: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1623: GUAGCUGCCU GAUGAGGCCG AAAGGCCGAA AGUGUGGU 38 INFORMATION FOR SEQ ID NO:1624: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1624: :"UUGCAGCUAC CCCGGGU 17 INFORMATION FOR SEQ ID NO:1625: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1625: ACCCGGGGCU GAUGAGGCCG AAAGGCCGAA AGCUGCAA 38 INFORMATION FOR SEQ ID NO:1626: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1626: CAGCACCUCC AUUGUGG 17 INFORMATION FOR SEQ ID NO:1627: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1627: CCACAAUGCU GAUGAGGCCG AAAGGCCGAA AGGUGCUG 38 INFORMATION FOR SEQ ID NO:1628: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1628: ACCUCCAUUG UGGACCA 17 INFORMATION FOR SEQ ID NO:1629: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1629: UGGUCCACCU GAUGAGGCCG AAAGGCCGAA AUGGAGGU 38 INFORMATION FOR SEQ ID NO:1630: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1630: CCAGACCUCA UGGGGAU 17 INFORMATION FOR SEQ ID NO:1631: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1631: AUCCCCAUCU GAUGAGGCCG AAAGGCCGAA AGGUCUGG 38 INFORMATION FOR SEQ ID NO:1632: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1632: AUGGGGAUAG UGCACCU 17 INFORMATION FOR SEQ ID NO:1633: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1633: AGGUGCACCU GAUGAGGCCG AAAGGCCGAA AUCCCCAU 350 INFORMATION FOR SEQ ID NO:1634: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1634: GCACCUGUUU CCUGUUU 17 INFORMATION FOR SEQ ID NO:1635: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1635: AAACAGGACU GAUGAGGCCG AAAGGCCGAA ACAGGUGC 38 INFORMATION FOR SEQ ID NO:1636: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1636: CACCUGUULUC CUGUUUG 17 INFORMATION FOR SEQ ID NO:1637: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1637: CAAACAGGCU GAUGAGGCCG AAAGGCCGAA AACAGGUG INFORMATION FOR SEQ ID NO:1638: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1638: ACCUGUUUCC UGUUUGG 17 INFORMATION FOR SEQ ID NO:1639: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1639: CCAAACAGCU GAUGAGGCCG AAAGGCCGAA AAACAGGU 38 INFORMATION FOR SEQ ID NO:1640: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1640: UUUCCUGUUU GGGAGAA 17 INFORMATION FOR SEQ ID NO:1641: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1641: S- UUCUCCCACU GAUGAGGCCG AAAGGCCGAA ACAGGAAA 38 INFORMATION FOR SEQ ID NO:1642: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1642: UUCCUGUUUG GGAGAAC 17 INFORMATION FOR SEQ ID NO:1643: SEQUENCE CHARACTERISTICS: oOO*** LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear

*S

o(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1643: GUUCUCCCCU GAUGAGGCCG AAAGGCCGAA AACAGGAA 38 INFORMATION FOR SEQ ID NO:1644: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1644: CACCCCAUCU CUGCCUG 17 INFORMATION FOR SEQ ID NO:1645: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1645: CAGGCAGACU GAUGAGGCCG AAAGGCCGAA AUGGGGUG 38 INFORMATION FOR SEQ ID NO:1646: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1646: CCCCAUCUCU GCCUGCA 17 INFORMATION FOR SEQ ID NO:1647: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1647: UGCAGGCACU GAUGAGGCCG AAAGGCCGAA AGAUGGGG 38 INFORMATION FOR SEQ ID NO:1648: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1648: CUGCAGAUCC CGGCUCC 17 INFORMATION FOR SEQ ID NO:1649: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1649: GGAGCCGGCU GAUGAGGCCG AAAGGCCGAA AUCUGCAG 38 INFORMATION FOR SEQ ID NO:1650: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1650: UCCCGGCUCC CUACCUG 17 INFORMATION FOR SEQ ID NO:1651: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1651: CAGGUAGGCU GAUGAGGCCG AAAGGCCGAA AGCCGGGA 38 INFORMATION FOR SEQ ID NO:1652: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1652: GGCUCCCUAC CUGAAGA 17 INFORMATION FOR SEQ ID NO:1653: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1653: UCUUCAGGCU GAUGAGGCCG AAAGGCCGAA AGGGAGCC 38 INFORMATION FOR SEQ ID NO:1654: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1654: SAAGUGCCUCA CCAGCAA 17 INFORMATION FOR SEQ ID NO:1655: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1655: UUGCUGGUCU GAUGAGGCCG AAAGGCCGAA AGGCACUU 38 INFORMATION FOR SEQ ID NO:1656: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1656: UGCAUGAUCG UCCACCA 17 INFORMATION FOR SEQ ID NO:1657: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1657: UGGUGGACCU GAUGAGGCCG AAAGGCCGAA AUCAUGCA 38 INFORMATION FOR SEQ ID NO:1658: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1658: AUGAUCGUCC ACCAGGG 17 INFORMATION FOR SEQ ID NO:1659: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1659: CCCUGGUGCU GAUGAGGCCG AAAGGCCGAA ACGAUCAU 38 INFORMATION FOR SEQ ID NO:1660: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1660: GGCACCAUUC UGGACAA 17 INFORMATION FOR SEQ ID NO:1661: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1661: UUGUCCAGCU GAUGAGGCCG AAAGGCCGAA AUGGUGCC 38 INFORMATION FOR SEQ ID NO:1662: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1662: GCACCAUUCU GGACAAU 17 INFORMATION FOR SEQ ID NO:1663: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1663: AUUGUCCACU GAUGAGGCCG AAAGGCCGAA AAUGGUGC 38 INFORMATION FOR SEQ ID NO:1664: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1664: GACAAUGUUA AGAACCU 17 INFORMATION FOR SEQ ID NO:1665: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1665: AGGUUCUUCU GAUGAGGCCG AAAGGCCGAA ACAUUGUC 38 INFORMATION FOR SEQ ID NO:1666: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1666: *ACAAUGUUAA GAACCUC 17 INFORMATION FOR SEQ ID NO:1667: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1667: GAGGUUCUCU GAUGAGGCCG AAAGGCCGAA AACAUUGU 38 INFORMATION FOR SEQ ID NO:1668: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1668: AAGAACCUCU UAGAAUU

I

Ba2 INFORMATION FOR SEQ ID NO:1669: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1669: AAUUCUAACU GAUGAGGCCG AAAGGCCGAA AGGUUCUU 38 INFORMATION FOR SEQ ID NO:1670: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1670: GAACCUCUUA GAAUUUG 17 INFORMATION FOR SEQ ID NO:1671: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1671: CAAAUUCUCU GAUGAGGCCG AAAGGCCGAA AGAGGUUC 38 INFORMATION FOR SEQ ID NO:1672: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1672: AACCUCUUAG AAUUUGC 17 INFORMATION FOR SEQ ID NO:1673: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1673: GCAAAUUCCU GAUGAGGCCG AAAGGCCGAA AAGAGGUU 38 INFORMATION FOR SEQ ID NO:1674: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1674: S CUUAGAAUUU GCAGAAA 17 INFORMATION FOR SEQ ID NO:1675: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1675: UUUCUGCACU GAUGAGGCCG AAAGGCCGAA AUUCUAAG 38 INFORMATION FOR SEQ ID NO:1676: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1676: UUAGAAUUUG

CAGAAAC

17 INFORMATION FOR SEQ ID NO:1677: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1677: SGUUUCUGCCU GAUGAGGCCG AAAGGCCGAA AAUUCUAA 38 INFORMATION FOR SEQ ID NO:1678: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1678: GAAACACUCC

AGUUUAU

17 INFORMATION FOR SEQ ID NO:1679: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1679: AUAAACUGCU GAUGAGGCCG AAAGGCCGAA AGUGUUUC 38 INFORMATION FOR SEQ ID NO:1680: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1680: ACUCCAGUUU

AUAGAUU

17 INFORMATION FOR SEQ ID NO:1681: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1681: AAUCUAUACU GAUGAGGCCG AAAGGCCGAA ACUGGAGU 38 INFORMATION FOR SEQ ID NO:1682: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1682: CUCCAGUUUA

UAGAUUC

17 INFORMATION FOR SEQ ID NO:1683: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1683: GAAUCUAUCU GAUGAGGCCG AAAGGCCGAA AACUGGAG 38 INFORMATION FOR SEQ ID NO:1684: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1684: UCCAGUUUAU

AGAUUCU

17 INFORMATION FOR SEQ ID NO:1685: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1685: AGAAUCUACU GAUGAGGCCG AAAGGCCGAA AAACUGGA 38 INFORMATION FOR SEQ ID NO:1686: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1686: CAGUUUAUAG AUUCUUU 17 INFORMATION FOR SEQ ID NO:1687: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1687: AAAGAAUCCU GAUGAGGCCG AAAGGCCGAA AUAAACUG 38 INFORMATION FOR SEQ ID NO:1688: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear J (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1688: Devoe: UUAUAGAUUC UUUCUUG 17 INFORMATION FOR SEQ ID NO:1689: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1689: CAAGAAAGCU GAUGAGGCCG AAAGGCCGAA AUCUAUAA 38 too* INFORMATION FOR SEQ ID NO:1690: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1690: UAUAGAUUCU UUCUUGA 17 INFORMATION FOR SEQ ID NO:1691: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1691: UCAAGAAACU GAUGAGGCCG AAAGGCCGAA AAUCUAUA 38 INFORMATION FOR SEQ ID NO:1692: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1692: UAGAUUCUUU CUUGAAC 17 INFORMATION FOR SEQ ID NO:1693: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1693: GUUCAAGACU GAUGAGGCCG AAAGGCCGAA AGAAUCUA 38 INFORMATION FOR SEQ ID NO:1694: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S"(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1694: AGAUUCUUUC UUGAACA 17 INFORMATION FOR SEQ ID NO:1695: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1695: UGUUCAAGCU GAUGAGGCCG AAAGGCCGAA AAGAAUCU 38 S. INFORMATION FOR SEQ ID NO:1696: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1696: GAUUCUUUCU UGAACAC 17 INFORMATION FOR SEQ ID NO:1697: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1697: GUGUUCAACU GAUGAGGCCG AAAGGCCGAA AAAGAAUC 38 INFORMATION FOR SEQ ID NO:1698: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1698: UUCUUUCUUG AACACUU 17 INFORMATION FOR SEQ ID NO:1699: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1699: AAGUGUUCCU GAUGAGGCCG AAAGGCCGAA AGAAAGAA 38 INFORMATION FOR SEQ ID NO:1700: SEQUENCE CHARACTERISTICS: S( A) LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1700: UGAACACUUC CAGCAAC 17 INFORMATION FOR SEQ ID NO:1701: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1701: GUUGCUGGCU GAUGAGGCCG AAAGGCCGAA AGUGUUCA 38 INFORMATION FOR SEQ ID NO:1702: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1702: GAACACUUCC AGCAACC 17 INFORMATION FOR SEQ ID NO:1703: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1703: GGUUGCUGCU GAUGAGGCCG AAAGGCCGAA AAGUGUUC 38 INFORMATION FOR SEQ ID NO:1704: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1704: UGAAAACUCG GGCUUAG 17 INFORMATION FOR SEQ ID NO:1705: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1705: CUAAGCCCCU GAUGAGGCCG AAAGGCCGAA AGUUUUCA 38 INFORMATION FOR SEQ ID NO:1706: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1706: CUCGGGCUUA GAUGCAC 17 INFORMATION FOR SEQ ID NO:1707: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1707: GUGCAUCUCU GAUGAGGCCG AAAGGCCGAA AGCCCGAG 38 INFORMATION FOR SEQ ID NO:1708: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1708: UCGGGCUUAG AUGCACC 17 INFORMATION FOR SEQ ID NO:1709: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1709: GGUGCAUCCU GAUGAGGCCG AAAGGCCGAA AAGCCCGA 38 INFORMATION FOR SEQ ID NO:1710: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1710: AUGCACCUAC CUUACCC 17 INFORMATION FOR SEQ ID NO:1711: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1711: GGGUAAGGCU GAUGAGGCCG AAAGGCCGAA AGGUGCAU 38 S, INFORMATION FOR SEQ ID NO:1712: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1712: ACCUACCUUA CCCUCCA 17 INFORMATION FOR SEQ ID NO:1713: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1713: UGGAGGGUCU GAUGAGGCCG AAAGGCCGAA AGGUAGGU 38 INFORMATION FOR SEQ ID NO:1714: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1714: CCUACCUUAC CCUCCAC 17 INFORMATION FOR SEQ ID NO:1715: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 4-OC (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1715: GUGGAGGGCU GAUGAGGCCG AAAGGCCGAA AAGGUAGG 38 INFORMATION FOR SEQ ID NO:1716: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1716: CUUACCCUCC ACUCCUC 17 INFORMATION FOR SEQ ID NO:1717: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear o* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1717: GAGGAGUGCU GAUGAGGCCG AAAGGCCGAA AGGGUAAG 38 INFORMATION FOR SEQ ID NO:1718: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1718: CCUCCACUCC UCUCAUU 17 INFORMATION FOR SEQ ID NO:1719: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1719: AAUGAGAGCU GAUGAGGCCG AAAGGCCGAA AGUGGAGG 38 INFORMATION FOR SEQ ID NO:1720: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1720: CCACUCCUCU CAUUGGU 17 INFORMATION FOR SEQ ID NO:1721: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid 1 STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1721: ACCAAUGACU GAUGAGGCCG AAAGGCCGAA AGGAGUGG 38 INFORMATION FOR SEQ ID NO:1722: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1722: ACUCCUCUCA UUGGUCA 17 INFORMATION FOR SEQ ID NO:1723: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1723: UGACCAAUCU GAUGAGGCCG AAAGGCCGAA AGAGGAGU 38 INFORMATION FOR SEQ ID NO:1724: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1724: SCCUCUCAUUG GUCACAA 17 INFORMATION FOR SEQ ID NO:1725: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1725: UUGUGACCCU GAUGAGGCCG AAAGGCCGAA AUGAGAGG 38 INFORMATION FOR SEQ ID NO:1726: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1726: UCAUUGGUCA CAAACUG 17 INFORMATION FOR SEQ ID NO:1727: 402 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1727: CAGUUUGUCU GAUGAGGCCG AAAGGCCGAA ACCAAUGA 38 INFORMATION FOR SEQ ID NO:1728: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1728: CACCAUGUCG AGACCAG 17 INFORMATION FOR SEQ ID NO:1729: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:1729: CUGGUCUCCU GAUGAGGCCG AAAGGCCGAA ACAUGGUG 38 INFORMATION FOR SEQ ID NO:1730: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1730: AGGAAAAUUC CAUCUUU 17 INFORMATION FOR SEQ ID NO:1731: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1731: AAAGAUGGCU GAUGAGGCCG AAAGGCCGAA AUUUUCCU 38 INFORMATION FOR SEQ ID NO:1732: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1732: GGAAAAUUCC AUCUUUA 17 INFORMATION FOR SEQ ID NO:1733: 4-03 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1733: UAAAGAUGCU GAUGAGGCCG AAAGGCCGAA AAUUUUCC 38 INFORMATION FOR SEQ ID NO:1734: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1734: AAUUCCAUCU UUAGAAC 17 INFORMATION FOR SEQ ID NO:1735: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1735: GUUCUAAACU GAUGAGGCCG AAAGGCCGAA AUGGAAUU 38 INFORMATION FOR SEQ ID NO:1736: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1736: UUCCAUCUUU AGAACUC 17 Sa INFORMATION FOR SEQ ID NO:1737: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1737: GAGUUCUACU GAUGAGGCCG AAAGGCCGAA AGAUGGAA 38 INFORMATION FOR SEQ ID NO:1738: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1738: UCCAUCUUUA GAACUCC 4-04- INFORMATION FOR SEQ ID NO:1739: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1739: GGAGUUCUCU GAUGAGGCCG AAAGGCCGAA AAGAUGGA 38 INFORMATION FOR SEQ ID NO:1740: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1740: CCAUCUUUAG AACUCCA 17 *o INFORMATION FOR SEQ ID NO:1741: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1741: UGGAGUUCCU GAUGAGGCCG AAAGGCCGAA AAAGAUGG 38 INFORMATION FOR SEQ ID NO:1742: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1742: UUAGAACUCC AGCUAUC INFORMATION FOR SEQ ID NO:1743: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1743: GAUAGCUGCU GAUGAGGCCG AAAGGCCGAA AGUUCUAA 38 INFORMATION FOR SEQ ID NO:1744: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1744: CUCCAGCUAU CAAAAGG 17 INFORMATION FOR SEQ ID NO:1745: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1745: CCUUUUGACU GAUGAGGCCG AAAGGCCGAA AGCUGGAG 38 INFORMATION FOR SEQ ID NO:1746: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1746: CCAGCUAUCA AAAGGUC 17 INFORMATION FOR SEQ ID NO:1747: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1747: GACCUUUUCU GAUGAGGCCG AAAGGCCGAA AUAGCUGG 38 INFORMATION FOR SEQ ID NO:1748: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1748: CAAAAGGUCA AUCCUCG 17 1 7 INFORMATION FOR SEQ ID NO:1749: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1749: CGAGGAUUCU GAUGAGGCCG AAAGGCCGAA ACCUUUUG 38 INFORMATION FOR SEQ ID NO:1750: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 400 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1750: AGGUCAAUCC UCGAAAG 17 INFORMATION FOR SEQ ID NO:1751: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1751: CUUUCGAGCU GAUGAGGCCG AAAGGCCGAA AUUGACCU 38 INFORMATION FOR SEQ ID NO:1752: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1752: UCAAUCCUCG AAAGCUC 17 INFORMATION FOR SEQ ID NO:1753: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:1753: GAGCUUUCCU GAUGAGGCCG AAAGGCCGAA AGGAUUGA 38 INFORMATION FOR SEQ ID NO:1754: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1754: CGAAAGCUCU CCUCGAA 17 INFORMATION FOR SEQ ID NO:1755: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1755: UUCGAGGACU GAUGAGGCCG AAAGGCCGAA AGCUUUCG 38 INFORMATION FOR SEQ ID NO:1756: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single 7 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1756: AAAGCUCUCC UCGAACU 17 INFORMATION FOR SEQ ID NO:1757: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1757: AGUUCGAGCU GAUGAGGCCG AAAGGCCGAA AGAGCUUU 38 INFORMATION FOR SEQ ID NO:1758: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1758: GCUCUCCUCG AACUCCC 17 INFORMATION FOR SEQ ID NO:1759: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1759: GGGAGUUCCU GAUGAGGCCG AAAGGCCGAA AGGAGAGC 38 INFORMATION FOR SEQ ID NO:1760: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1760: CUCGAACUCC CACACCA 17 INFORMATION FOR SEQ ID NO:1761: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1761: UGGUGUGGCU GAUGAGGCCG AAAGGCCGAA AGUUCGAG 38 INFORMATION FOR SEQ ID NO:1762: SEQUENCE CHARACTERISTICS: 4OS LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1762: CACACCAUUC AAACAUG 17 INFORMATION FOR SEQ ID NO:1763: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1763: CAUGUUUGCU GAUGAGGCCG AAAGGCCGAA AUGGUGUG 38 INFORMATION FOR SEQ ID NO:1764: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1764: ACACCAUUCA AACAUGC 17 INFORMATION FOR SEQ ID NO:1765: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S* TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1765: GCAUGUUUCU GAUGAGGCCG AAAGGCCGAA AAUGGUGU 38 INFORMATION FOR SEQ ID NO:1766: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1766: CAUGCCCUUG CAGCUCA 17 INFORMATION FOR SEQ ID NO:1767: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1767: UGAGCUGCCU GAUGAGGCCG AAAGGCCGAA AGGGCAUG

AA

4-09 INFORMATION FOR SEQ ID NO:1768: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1768: UUGCAGCUCA AGAAAUU 17 INFORMATION FOR SEQ ID NO:1769: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1769: AAUUUCUUCU GAUGAGGCCG AAAGGCCGAA AGCUGCAA 38 INFORMATION FOR SEQ ID NO:1770:

S*

SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1770: CAAGAAAUUA AAUACGG 17 17 INFORMATION FOR SEQ ID NO:1771: S(i) SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid S STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1771: CCGUAUUUCU GAUGAGGCCG AAAGGCCGAA AUUUCUUG 38 INFORMATION FOR SEQ ID NO:1772: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1772: AAGAAAUUAA AUACGGU 17 INFORMATION FOR SEQ ID NO:1773: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1773: ACCGUAUUCU GAUGAGGCCG AAAGGCCGAA

AAUUUCUU

INFORMATION FOR SEQ ID NO:1774: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1774: AAUUAAAUAC GGUCCCC INFORMATION FOR SEQ ID NO:1775: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1775: GGGGACCGCU GAUGAGGCCG AAAGGCCGAA AUUUAAUU 38 INFORMATION FOR SEQ ID NO:1776: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S" TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1776: AAUACGGUCC CCUGAAG 17 INFORMATION FOR SEQ ID NO:1777: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1777: .CUUCAGGGCU GAUGAGGCCG AAAGGCCGAA ACCGUAUU 38 INFORMATION FOR SEQ ID N0:1778: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1778: AAGAUGCUAC CUCAGAC 17 INFORMATION FOR SEQ ID NO:1779: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1779: 4-1 GUCUGAGGCU GAUGAGGCCG AAAGGCCGAA AGCAUCUU 38 INFORMATION FOR SEQ ID NO:1780: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1780: UGCUACCUCA GACCCCC 17 INFORMATION FOR SEQ ID NO:1781: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1781: GGGGGUCUCU GAUGAGGCCG AAAGGCCGAA AGGUAGCA 38 INFORMATION FOR SEQ ID NO:1782: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S(B) TYPE: nucleic acid S. STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1782: GACCCCCUCC CAUGCAG 17 INFORMATION FOR SEQ ID NO:1783: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1783: CUGCAUGGCU GAUGAGGCCG AAAGGCCGAA AGGGGGUC 38 INFORMATION FOR SEQ ID NO:1784: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1784: GAGGACCUAC AAGAUGU 17 INFORMATION FOR SEQ ID NO:1785: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 4-12 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1785: ACAUCUUGCU GAUGAGGCCG AAAGGCCGAA AGGUCCUC 38 INFORMATION FOR SEQ ID NO:1786: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1786: GAUGUGAUUA AGCGGGA 17 INFORMATION FOR SEQ ID NO:1787: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1787: UCCCGCUUCU GAUGAGGCCG AAAGGCCGAA AUCACAUC 38 INFORMATION FOR SEQ ID NO:1788: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1788: SAUGUGAUUAA GCGGGAA 17 INFORMATION FOR SEQ ID NO:1789: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1789: UUCCCGCUCU GAUGAGGCCG AAAGGCCGAA AAUCACAU 38 INFORMATION FOR SEQ ID NO:1790: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1790: GCGGGAAUCG GAUGAAU 17 INFORMATION FOR SEQ ID NO:1791: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 4- i3 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1791: AUUCAUCCCU GAUGAGGCCG AAAGGCCGAA AUUCCCGC 38 INFORMATION FOR SEQ ID NO:1792: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1792: GGAUGAAUCU GGAAUUG 17 INFORMATION FOR SEQ ID NO:1793: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1793: CAAUUCCACU GAUGAGGCCG AAAGGCCGAA AUUCAUCC 38 S* INFORMATION FOR SEQ ID NO:1794: .o SEQUENCE CHARACTERISTICS: 0* LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1794: UCUGGAAUUG UUGCUGA 17 INFORMATION FOR SEQ ID NO:1795: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear *eeoc° (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1795: UCAGCAACCU GAUGAGGCCG AAAGGCCGAA AUUCCAGA 38 INFORMATION FOR SEQ ID NO:1796: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1796: GGAAUUGUUG CUGAGUU 17 INFORMATION FOR SEQ ID NO:1797: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1797: AACUCAGCCU GAUGAGGCCG AAAGGCCGAA ACAAUUCC 38 INFORMATION FOR SEQ ID NO:1798: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1798: UGCUGAGUUU CAAGAGA 17 INFORMATION FOR SEQ ID NO:1799: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1799: UCUCUUGACU GAUGAGGCCG AAAGGCCGAA ACUCAGCA 38 INFORMATION FOR SEQ ID NO:1800: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1800: GCUGAGUUUC AAGAGAG 17 INFORMATION FOR SEQ ID NO:1801: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 38 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1801: CUCUCUUGCU GAUGAGGCCG AAAGGCCGAA AACUCAGC 38 INFORMATION FOR SEQ ID NO:1802: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1802: CUGAGUUUCA AGAGAGU 17 INFORMATION FOR SEQ ID NO:1803: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1803: ACUCUCUUCU GAUGAGGCCG AAAGGCCGAA AAACUCAG INFORMATION FOR SEQ ID NO:1804: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1804: ACCACCGUUA CUGAAAA INFORMATION FOR SEQ ID NO:1805: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1805: UUUUCAGUCU GAUGAGGCCG AAAGGCCGAA ACGGUGGU INFORMATION FOR SEQ ID NO:1806: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1806: CCACCGUUAC UGAAAAA INFORMATION FOR SEQ ID NO:1807: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1807: UUUUUCAGCU GAUGAGGCCG AAAGGCCGAA AACGGUGG INFORMATION FOR SEQ ID NO:1808: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1808: AAAAAAAUCA AGCAGGC INFORMATION FOR SEQ ID NO:1809: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1809: GCCUGCUUCU GAUGAGGCCG AAAGGCCGAA AUUUUUUU 38 INFORMATION FOR SEQ ID NO:1810: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1810: GGUGGAGUCG CCAACUG 17 INFORMATION FOR SEQ ID NO:1811: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1811: CAGUUGGCCU GAUGAGGCCG AAAGGCCGAA ACUCCACC 38 INFORMATION FOR SEQ ID NO:1812: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1812: UGAGAAAUCG GGAAACU 17

S.

INFORMATION FOR SEQ ID NO:1813: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1813: AGUUUCCCCU GAUGAGGCCG AAAGGCCGAA AUUUCUCA 38 INFORMATION FOR SEQ ID NO:1814: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1814: 4-i-7 GGGAAACUUC UUCUGCU 17 INFORMATION FOR SEQ ID NO:1815: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1815: AGCAGAAGCU GAUGAGGCCG AAAGGCCGAA AGUUUCCC 38 INFORMATION FOR SEQ ID NO:1816: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1816: GGAAACUUCU UCUGCUC 17 INFORMATION FOR SEQ ID NO:1817: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1817: GAGCAGAACU GAUGAGGCCG AAAGGCCGAA AAGUUUCC 38 INFORMATION FOR SEQ ID NO:1818: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single o* TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1818: AAACUUCUUC UGCUCAA 17 INFORMATION FOR SEQ ID NO:1819: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1819: UUGAGCAGCU GAUGAGGCCG AAAGGCCGAA AGAAGUUU 38 INFORMATION FOR SEQ ID NO:1820: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 4-IS (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1820: AACUUCUUCU GCUCAAA 17 INFORMATION FOR SEQ ID NO:1821: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1821: UUUGAGCACU GAUGAGGCCG AAAGGCCGAA AAGAAGUU 38 INFORMATION FOR SEQ ID NO:1822: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1822: CUUCUGCUCA AACCACU 17 o*o* INFORMATION FOR SEQ ID NO:1823: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1823: AGUGGUUUCU GAUGAGGCCG AAAGGCCGAA AGCAGAAG 38 INFORMATION FOR SEQ ID NO:1824: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1824: CCAACUGUUC UCGCAGG 17 INFORMATION FOR SEQ ID NO:1825: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1825: CCUGCGAGCU GAUGAGGCCG AAAGGCCGAA ACAGUUGG 38 INFORMATION FOR SEQ ID NO:1826: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1826: CAACUGUUCU CGCAGGC 17 INFORMATION FOR SEQ ID NO:1827: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1827: GCCUGCGACU GAUGAGGCCG AAAGGCCGAA AACAGUUG 38 INFORMATION FOR SEQ ID NO:1828: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1828: S ACUGUUCUCG CAGGCGU 17 '*ee INFORMATION FOR SEQ ID NO:1829: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1829: ACGCCUGCCU GAUGAGGCCG AAAGGCCGAA AGAACAGU 38 INFORMATION FOR SEQ ID NO:1830: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1830: GCAGGCGUCU CCUGUGG 17 INFORMATION FOR SEQ ID NO:1831: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1831: CCACAGGACU GAUGAGGCCG AAAGGCCGAA ACGCCUGC 38 INFORMATION FOR SEQ ID NO:1832: 4- SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1832: AGGCGUCUCC UGUGGCA 17 INFORMATION FOR SEQ ID NO:1833: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1833: UGCCACAGCU GAUGAGGCCG AAAGGCCGAA AGACGCCU 38 INFORMATION FOR SEQ ID NO:1834: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1834: CCCCAAAUAU UCUUACA 17 INFORMATION FOR SEQ ID NO:1835: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:1835: UGUAAGAACU GAUGAGGCCG AAAGGCCGAA AUUUGGGG 38 INFORMATION FOR SEQ ID NO:1836: i: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1836: CCAAAUAUUC UUACAAG 17 INFORMATION FOR SEQ ID NO:1837: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1837: CUUGUAAGCU GAUGAGGCCG AAAGGCCGAA AUAUUUGG 38 INFORMATION FOR SEQ ID NO:1838: 4-Zi SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1838: CAAAUAUUCU UACAAGC 17 INFORMATION FOR SEQ ID NO:1839: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1839: GCUUGUAACU GAUGAGGCCG AAAGGCCGAA AAUAUUUG 38 INFORMATION FOR SEQ ID NO:1840: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1840: AAUAUUCUUA CAAGCUC 17 INFORMATION FOR SEQ ID NO:1841: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1841: GAGCUUGUCU GAUGAGGCCG AAAGGCCGAA AGAAUAUU 38 S(2) INFORMATION FOR SEQ ID NO:1842: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1842: AUAUUCUUAC AAGCUCU 17 INFORMATION FOR SEQ ID NO:1843: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1843: AGAGCUUGCU GAUGAGGCCG AAAGGCCGAA AAGAAUAU 4-22 INFORMATION FOR SEQ ID NO:1844: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1844: UACAAGCUCU GUUUUAA 17 INFORMATION FOR SEQ ID NO:1845: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1845: UUAAAACACU GAUGAGGCCG AAAGGCCGAA AGCUUGUA 38 INFORMATION FOR SEQ ID NO:1846: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear 4 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1846: AGCUCUGUUU UAAUGAC 17 INFORMATION FOR SEQ ID NO:1847: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1847: S GUCAUUAACU GAUGAGGCCG AAAGGCCGAA ACAGAGCU 38 38 INFORMATION FOR SEQ ID NO:1848: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1848: GCUCUGUUUU AAUGACA 17 INFORMATION FOR SEQ ID NO:1849: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1849: +23 UGUCAUUACU GAUGAGGCCG AAAGGCCGAA AACAGAGC 38 INFORMATION FOR SEQ ID NO:1850: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1850: CUCUGUUUUA AUGACAC 17 INFORMATION FOR SEQ ID NO:1851: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1851: GUGUCAUUCU GAUGAGGCCG AAAGGCCGAA AAACAGAG 38 INFORMATION FOR SEQ ID NO:1852: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1852: UCUGUUUUAA UGACACC 17 INFORMATION FOR SEQ ID NO:1853: SEQUENCE CHARACTERISTICS: C LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1853: 4 GGUGUCAUCU GAUGAGGCCG AAAGGCCGAA AAAACAGA 38 INFORMATION FOR SEQ ID NO:1854: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1854: ACACCUGUAU CAGAAGA 17 INFORMATION FOR SEQ ID NO:1855: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 42+ (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1855: UCUUCUGACU GAUGAGGCCG AAAGGCCGAA ACAGGUGU 38 INFORMATION FOR SEQ ID NO:1856: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1856: ACCUGUAUCA GAAGAUG 17 INFORMATION FOR SEQ ID NO:1857: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1857: CAUCUUCUCU GAUGAGGCCG AAAGGCCGAA AUACAGGU 38 INFORMATION FOR SEQ ID NO:1858: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1858: SGACAAUGUCC UCAAAGC 17 INFORMATION FOR SEQ ID NO:1859: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1859: GCUUUGAGCU GAUGAGGCCG AAAGGCCGAA ACAUUGUC 38 INFORMATION FOR SEQ ID NO:1860: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1860: AAUGUCCUCA AAGCCUU 17 INFORMATION FOR SEQ ID NO:1861: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1861: AAGGCUUUCU GAUGAGGCCG AAAGGCCGAA AGGACAUU 38 INFORMATION FOR SEQ ID NO:1862: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1862: CAAAGCCUUU ACCGUAC 17 INFORMATION FOR SEQ ID NO:1863: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1863: GUACGGUACU GAUGAGGCCG AAAGGCCGAA

AGGCUUUG

S

INFORMATION FOR SEQ ID N0:1864: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1864: AAAGCCUUUA CCGUACC 17 INFORMATION FOR SEQ ID NO:1865: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1865: GGUACGGUCU GAUGAGGCCG AAAGGCCGAA AAGGCUUU 38 INFORMATION FOR SEQ ID NO:1866: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1866: AAGCCUUUAC CGUACCU 17 INFORMATION FOR SEQ ID NO:1867: SEQUENCE CHARACTERISTICS: 4-2G LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1867: AGGUACGGCU GAUGAGGCCG AAAGGCCGAA AAAGGCUU 38 INFORMATION FOR SEQ ID NO:1868: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1868: UUUACCGUAC CUAAGAA 17 INFORMATION FOR SEQ ID NO:1869: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1869: a. UUCUUAGGCU GAUGAGGCCG AAAGGCCGAA ACGGUAAA 38 INFORMATION FOR SEQ ID NO:1870: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1870:

C

CCGUACCUAA GAACAGG 17 INFORMATION FOR SEQ ID NO:1871: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1871: CCUGUUCUCU GAUGAGGCCG AAAGGCCGAA AGGUACGG 38 INFORMATION FOR SEQ ID NO:1872: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1872: UGGUGGGUCC

CUUGCAG

4-27 INFORMATION FOR SEQ ID NO:1873: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1873: CUGCAAGGCU GAUGAGGCCG AAAGGCCGAA ACCCACCA 38 INFORMATION FOR SEQ ID NO:1874: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1874: GGGUCCCUUG CAGCCAU 17 INFORMATION FOR SEQ ID NO:1875: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1875: AUGGCUGCCU GAUGAGGCCG AAAGGCCGAA AGGGACCC 38 INFORMATION FOR SEQ ID NO:1876: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1876: GCCAGCAUCC UGUGGGA 17 INFORMATION FOR SEQ ID N0:1877: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1877: UCCCACAGCU GAUGAGGCCG AAAGGCCGAA AUGCUGGC 38 INFORMATION FOR SEQ ID NO:1878: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1878: GACGGCCUCC GGUCCGG INFORMATION FOR SEQ ID NO:1879: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1879: CCGGACCGCU GAUGAGGCCG AAAGGCCGAA AGGCCGUC 38 INFORMATION FOR SEQ ID NO:1880: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1880: CCUCCGGUCC GGCUCGG 17 INFORMATION FOR SEQ ID NO:1881: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1881: CCGAGCCGCU GAUGAGGCCG AAAGGCCGAA ACCGGAGG 38 INFORMATION FOR SEQ ID NO:1882: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1882: *GUCCGGCUCG GAAAUAC 17 INFORMATION FOR SEQ ID NO:1883: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1883: GUAUUUCCCU GAUGAGGCCG AAAGGCCGAA AGCCGGAC 38 INFORMATION FOR SEQ ID NO:1884: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1884: 4-2q S UCGGAAAUAC GUGAACG 17 INFORMATION FOR SEQ ID NO:1885: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1885: CGUUCACGCU GAUGAGGCCG AAAGGCCGAA AUUUCCGA 38 INFORMATION FOR SEQ ID NO:1886: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1886: GAACGCGUUC UCAGCUC 17 INFORMATION FOR SEQ ID NO:1887: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1887: GAGCUGAGCU GAUGAGGCCG AAAGGCCGAA ACGCGUUC 38 INFORMATION FOR SEQ ID NO:1888: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1888: SAACGCGUUCU CAGCUCG 17 INFORMATION FOR SEQ ID NO:1889: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1889: CGAGCUGACU GAUGAGGCCG AAAGGCCGAA AACGCGUU 38 INFORMATION FOR SEQ ID NO:1890: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 4-30 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1890: CGCGUUCUCA GCUCGAA 17 INFORMATION FOR SEQ ID NO:1891: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1891: UUCGAGCUCU GAUGAGGCCG AAAGGCCGAA AGAACGCG 38 INFORMATION FOR SEQ ID NO:1892: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1892: UCUCAGCUCG AACUCUG 17 17 INFORMATION FOR SEQ ID NO:1893: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:1893: CAGAGUUCCU GAUGAGGCCG AAAGGCCGAA AGCUGAGA 38 INFORMATION FOR SEQ ID NO:1894: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear S* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1894: CUCGAACUCU GGUCAUG 17 INFORMATION FOR SEQ ID NO:1895: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1895: CAUGACCACU GAUGAGGCCG AAAGGCCGAA AGUUCGAG 38 INFORMATION FOR SEQ ID N0:1896: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single 9 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1896: ACUCUGGUCA

UGUGAGA

17 INFORMATION FOR SEQ ID NO:1897: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1897: UCUCACAUCU GAUGAGGCCG AAAGGCCGAA ACCAGAGU 38 INFORMATION FOR SEQ ID NO:1898: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1898: UGAGACAUUU CCAGAAA 17 17 INFORMATION FOR SEQ ID NO:1899: S* SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1899: UUUCUGGACU GAUGAGGCCG AAAGGCCGAA AUGUCUCA 38 INFORMATION FOR SEQ ID NO:1900: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1900: GAGACAUUUC CAGAAAA 17 INFORMATION FOR SEQ ID NO:1901: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1901: UUUUCUGGCU GAUGAGGCCG AAAGGCCGAA AAUGUCUC 38 INFORMATION FOR SEQ ID NO:1902: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs -32 TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1902: AGACAUUUCC AGAAAAG 17 INFORMATION FOR SEQ ID NO:1903: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1903: CUUUUCUGCU GAUGAGGCCG AAAGGCCGAA AAAUGUCU 38 INFORMATION FOR SEQ ID NO:1904: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1904: AAAAGCAUUA UGGUUUU 17 S* INFORMATION FOR SEQ ID NO:1905: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1905: AAAACCAUCU GAUGAGGCCG AAAGGCCGAA AUGCUUUU 38 INFORMATION FOR SEQ ID NO:1906: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1906: AAAGCAUUAU GGUUUUC 17 INFORMATION FOR SEQ ID NO:1907: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1907: GAAAACCACU GAUGAGGCCG AAAGGCCGAA AAUGCUUU 38 INFORMATION FOR SEQ ID NO:1908: 4-33 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1908: AUUAUGGUUU UCAGAAC 17 INFORMATION FOR SEQ ID NO:1909: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1909: GUUCUGAACU GAUGAGGCCG AAAGGCCGAA ACCAUAAU 38 INFORMATION FOR SEQ ID NO:1910: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1910: UUAUGGUUUU CAGAACA 17 INFORMATION FOR SEQ ID NO:1911: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:1911: UGUUCUGACU GAUGAGGCCG AAAGGCCGAA AACCAUAA 38 INFORMATION FOR SEQ ID NO:1912: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1912: UAUGGUUUUC AGAACAC 17 INFORMATION FOR SEQ ID NO:1913: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1913: GUGUUCUGCU GAUGAGGCCG AAAGGCCGAA AAACCAUA 1o INFORMATION FOR SEQ ID NO:1914: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1914: AUGGUUUUCA GAACACU 17 INFORMATION FOR SEQ ID NO:1915: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1915: AGUGUUCUCU GAUGAGGCCG AAAGGCCGAA AAAACCAU 38 INFORMATION FOR SEQ ID NO:1916: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1916: AGAACACUUA AAAGUUG 17 INFORMATION FOR SEQ ID NO:1917: i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1917: CAACUUUUCU GAUGAGGCCG AAAGGCCGAA AGUGUUCU 38 INFORMATION FOR SEQ ID NO:1918: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1918: GAACACUUAA AAGUUGA 17 INFORMATION FOR SEQ ID NO:1919: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1919: UCAACUUUCU GAUGAGGCCG AAAGGCCGAA AAGUGUUC 38 INFORMATION FOR SEQ ID NO:1920: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1920: UUAAAAGUUG ACUUUCG 17 INFORMATION FOR SEQ ID NO:1921: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1921: CGAAAGUCCU GAUGAGGCCG AAAGGCCGAA ACUUUUAA 38 INFORMATION FOR SEQ ID NO:1922: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1922: AGUUGACUUU CGACACA 17 INFORMATION FOR SEQ ID NO:1923: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1923: UGUGUCGACU GAUGAGGCCG AAAGGCCGAA AGUCAACU 38 INFORMATION FOR SEQ ID NO:1924: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1924: GUUGACUUUC GACACAU 17 INFORMATION FOR SEQ ID NO:1925: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 4-3 G (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1925: AUGUGUCGCU GAUGAGGCCG AAAGGCCGAA AAGUCAAC 38 INFORMATION FOR SEQ ID NO:1926: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1926: UUGACUUUCG ACACAUG 17 INFORMATION FOR SEQ ID NO:1927: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1927: CAUGUGUCCU GAUGAGGCCG AAAGGCCGAA AAAGUCAA 38 INFORMATION FOR SEQ ID NO:1928: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1928: ACAUGGCUCC UCAGCGU 17 INFORMATION FOR SEQ ID NO:1929: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1929: ACGCUGAGCU GAUGAGGCCG AAAGGCCGAA AGCCAUGU 38 INFORMATION FOR SEQ ID NO:1930: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1930: UGGCUCCUCA GCGUGGA 17 INFORMATION FOR SEQ ID NO:1931: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid 4-37 STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1931: UCCACGCUCU GAUGAGGCCG AAAGGCCGAA AGGAGCCA 38 INFORMATION FOR SEQ ID NO:1932: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1932: GGAGCGCUCC AUGGCUG 17 INFORMATION FOR SEQ ID NO:1933: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1933: CAGCCAUGCU GAUGAGGCCG AAAGGCCGAA AGCGCUCC 38 3.

INFORMATION FOR SEQ ID NO:1934: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1934: AGCCUGAUUU UGUUGUG 17 17 INFORMATION FOR SEQ ID NO:1935: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1935: CACAACAACU GAUGAGGCCG AAAGGCCGAA AUCAGGCU 38 INFORMATION FOR SEQ ID NO:1936: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1936: GCCUGAUUUU GUUGUGG 17 INFORMATION FOR SEQ ID NO:1937: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1937: CCACAACACU GAUGAGGCCG AAAGGCCGAA AAUCAGGC 38 INFORMATION FOR SEQ ID NO:1938: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1938: CCUGAUUUUG UUGUGGU 17 INFORMATION FOR SEQ ID NO:1939: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1939: ACCACAACCU GAUGAGGCCG AAAGGCCGAA AAAUCAGG 38 INFORMATION FOR SEQ ID NO:1940: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear :0&4V (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1940: GAUUUUGUUG UGGUACA 17 INFORMATION FOR SEQ ID NO:1941: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1941: UGUACCACCU GAUGAGGCCG AAAGGCCGAA ACAAAAUC 38 INFORMATION FOR SEQ ID NO:1942: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1942: GUUGUGGUAC AACAGUU 17 INFORMATION FOR SEQ ID NO:1943: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1943: AACUGUUGCU GAUGAGGCCG AAAGGCCGAA ACCACAAC 38 INFORMATION FOR SEQ ID NO:1944: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1944: ACAACAGUUG AGAGCAG INFORMATION FOR SEQ ID NO:1945: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1945: CUGCUCUCCU GAUGAGGCCG AAAGGCCGAA ACUGUUGU 38 INFORMATION FOR SEQ ID NO:1946: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1946: 0. AAGUGCAUUU

UUAGUUG

:1 7 INFORMATION FOR SEQ ID NO:1947: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1947: CAACUAAACU GAUGAGGCCG AAAGGCCGAA AUGCACUU 38 INFORMATION FOR SEQ ID NO:1948: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1948: AGUGCAUUU

UAGUUGC

44-0 INFORMATION FOR SEQ ID NO:1949: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1949: GCAACUAACU GAUGAGGCCG AAAGGCCGAA AAUGCACU 38 INFORMATION FOR SEQ ID NO:1950: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1950: GUGCAUUUUU AGUUGCU 17 INFORMATION FOR SEQ ID NO:1951: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1951: S AGCAACUACU GAUGAGGCCG AAAGGCCGAA AAAUGCAC 38 INFORMATION FOR SEQ ID NO:1952: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1952: UGCAUUUUUA GUUGCUU 17 INFORMATION FOR SEQ ID NO:1953: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1953: AAGCAACUCU GAUGAGGCCG AAAGGCCGAA AAAAUGCA 38 INFORMATION FOR SEQ ID NO:1954: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1954: 4- 1 GCAUUUUUAG UUGCUUG 17 INFORMATION FOR SEQ ID NO:1955: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1955: CAAGCAACCU GAUGAGGCCG AAAGGCCGAA AAAAAUGC 38 INFORMATION FOR SEQ ID NO:1956: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1956: UUUUUAGUUG CUUGAGA 17 INFORMATION FOR SEQ ID NO:1957: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1957: UCUCAAGCCU GAUGAGGCCG AAAGGCCGAA ACUAAAAA 38 INFORMATION FOR SEQ ID NO:1958: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear o(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1958: UAGUUGCUUG AGAUCUC 17 INFORMATION FOR SEQ ID NO:1959: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1959: GAGAUCUCCU GAUGAGGCCG AAAGGCCGAA AGCAACUA 38 INFORMATION FOR SEQ ID NO:1960: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 4-4-2 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1960: CUUGAGAUCU CACUUGA 17 INFORMATION FOR SEQ ID NO:1961: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1961: UCAAGUGACU GAUGAGGCCG AAAGGCCGAA AUCUCAAG 38 INFORMATION FOR SEQ ID NO:1962: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1962: UGAGAUCUCA CUUGAUU 17 INFORMATION FOR SEQ ID NO:1963: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1963: AAUCAAGUCU GAUGAGGCCG AAAGGCCGAA AGAUCUCA 38 INFORMATION FOR SEQ ID NO:1964: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1964: AUCUCACUUG AUUUCAC 17 INFORMATION FOR SEQ ID NO:1965: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1965: GUGAAAUCCU GAUGAGGCCG AAAGGCCGAA AGUGAGAU 38 INFORMATION FOR SEQ ID NO:1966: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single 4-43 0 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1966: CACUUGAUUU CACACAA INFORMATION FOR SEQ ID NO:1967: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1967: UUGUGUGACU GAUGAGGCCG AAAGGCCGAA AUCAAGUG 38 INFORMATION FOR SEQ ID NO:1968: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1968: ACUUGAUUUC

ACACAAC

17 INFORMATION FOR SEQ ID NO:1969: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1969: GUUGUGUGCU GAUGAGGCCG AAAGGCCGAA AAUCAAGU 38 INFORMATION FOR SEQ ID NO:1970: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1970: CUUGAUUUCA CACAACU 17 INFORMATION FOR SEQ ID NO:1971: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1971: AGUUGUGUCU GAUGAGGCCG AAAGGCCGAA AAAUCAAG 38 INFORMATION FOR SEQ ID NO:1972: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1972: ACACAACUAA AAAGGAU 17 INFORMATION FOR SEQ ID NO:1973: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1973: AUCCUUUUCU GAUGAGGCCG AAAGGCCGAA AGUUGUGU 38 INFORMATION FOR SEQ ID NO:1974: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs So. TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1974: SAAAAGGAUUU UUUUUUU 17 INFORMATION FOR SEQ ID NO:1975: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1975: AAAAAAAACU GAUGAGGCCG AAAGGCCGAA AUCCUUUU 38 INFORMATION FOR SEQ ID NO:1976: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1976: AAAGGAUUUU UUUUUUA 17 INFORMATION FOR SEQ ID NO:1977: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1977: UAAAAAAACU GAUGAGGCCG AAAGGCCGAA AAUCCUUU INFORMATION FOR SEQ ID NO:1978: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1978: AAGGAUUUU UUUUUAA 17 INFORMATION FOR SEQ ID NO:1979: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1979: UUAAAAAACU GAUGAGGCCG AAAGGCCGAA AAAUCCUU 38 INFORMATION FOR SEQ ID NO:1980: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1980: AGGAUUUUUU UUUUAAA 17 S* INFORMATION FOR SEQ ID NO:1981: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1981: UUUAAAAACU GAUGAGGCCG AAAGGCCGAA AAAAUCCU 38 o INFORMATION FOR SEQ ID NO:1982: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1982: GGAUUUUUUU UUUAAAA 17 INFORMATION FOR SEQ ID NO:1983: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1983: UUUUAAAACU GAUGAGGCCG AAAGGCCGAA AAAAAUCC o INFORMATION FOR SEQ ID NO:1984: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1984: GAUUUUUUU UUAAAAA 17 INFORMATION FOR SEQ ID NO:1985: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1985: UUUUUAAACU GAUGAGGCCG AAAGGCCGAA AAAAAAUC 38 INFORMATION FOR SEQ ID NO:1986: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1986: AUUUUUUUUU UAAAAAU 17 INFORMATION FOR SEQ ID NO:1987: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1987: SAUUUUUAACU GAUGAGGCCG AAAGGCCGAA AAAAAAAU 38 INFORMATION FOR SEQ ID NO:1988: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1988: UUUUUUUUU AAAAAUA 17 INFORMATION FOR SEQ ID NO:1989: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1989: 4-47 UAUUUUUACU GAUGAGGCCG AAAGGCCGAA AAAAAAAA 38 INFORMATION FOR SEQ ID NO:1990: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1990: UUUUUUUUUA AAAAUAA 17 INFORMATION FOR SEQ ID NO:1991: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1991: UUAUUUUUCU GAUGAGGCCG AAAGGCCGAA AAAAAAAA 38 INFORMATION FOR SEQ ID NO:1992: SEQUENCE CHARACTERISTICS: S* LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1992: UUUUUUUUAA AAAUAAU 17 INFORMATION FOR SEQ ID NO:1993: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear a o (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1993: AUUAUUUUCU GAUGAGGCCG AAAGGCCGAA AAAAAAAA 38 INFORMATION FOR SEQ ID NO:1994: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1994: UUAAAAAUAA UAAUAAU 17 INFORMATION FOR SEQ ID NO:1995: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1995: AUUAUUAUCU GAUGAGGCCG AAAGGCCGAA AUUUUUAA 38 INFORMATION FOR SEQ ID NO:1996: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1996: AAAAUAAUAA UAAUGAA 17 INFORMATION FOR SEQ ID NO:1997: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1997: UUCAUUAUCU GAUGAGGCCG AAAGGCCGAA AUUAUUUU 38 INFORMATION FOR SEQ ID NO:1998: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1998: AUAAUAAUAA UGAAUAA 17 INFORMATION FOR SEQ ID NO:1999: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1999: UUAUUCAUCU GAUGAGGCCG AAAGGCCGAA AUUAUUAU 38 INFORMATION FOR SEQ ID NO:2000: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2000: UAAUGAAUAA CAGUCUU 17 INFORMATION FOR SEQ ID NO:2001: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2001: AAGACUGUCU GAUGAGGCCG AAAGGCCGAA AUUCAUUA 38 INFORMATION FOR SEQ ID NO:2002: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2002: AUAACAGUCU UACCUAA 17 INFORMATION FOR SEQ ID NO:2003: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear .9 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2003: UUAGGUAACU GAUGAGGCCG AAAGGCCGAA ACUGUUAU 38 38 INFORMATION FOR SEQ ID NO:2004: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2004: AACAGUCUUA CCUAAAU 17 o INFORMATION FOR SEQ ID NO:2005: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2005: AUUUAGGUCU GAUGAGGCCG AAAGGCCGAA AGACUGUU 38 INFORMATION FOR SEQ ID NO:2006: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2006: ACAGUCUUAC CUAAAUU 17 INFORMATION FOR SEQ ID NO:2007: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2007: AAUUUAGGCU GAUGAGGCCG AAAGGCCGAA AAGACUGU 38 INFORMATION FOR SEQ ID NO:2008: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2008: UCUUACCUAA AUUAUUA 17 INFORMATION FOR SEQ ID NO:2009: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2009: UAAUAAUUCU GAUGAGGCCG AAAGGCCGAA AGGUAAGA 38 INFORMATION FOR SEQ ID NO:2010: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2010: lo ACCUAAAUUA UUAGGUA 17 i. INFORMATION FOR SEQ ID NO:2011: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2011: UACCUAAUCU GAUGAGGCCG AAAGGCCGAA AUUUAGGU 38 INFORMATION FOR SEQ ID NO:2012: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2012: CCUAAAUUAU UAGGUAA 17 INFORMATION FOR SEQ ID NO:2013: 451 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2013: UUACCUAACU GAUGAGGCCG AAAGGCCGAA AAUUUAGG 38 INFORMATION FOR SEQ ID NO:2014: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2014: UAAAUUAUUA GGUAAUG 17 INFORMATION FOR SEQ ID NO:2015: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single S* TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2015: CAUUACCUCU GAUGAGGCCG AAAGGCCGAA AUAAUUUA 38 INFORMATION FOR SEQ ID NO:2016: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2016: AAAUUAUUAG GUAAUGA 17 INFORMATION FOR SEQ ID NO:2017: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2017: UCAUUACCCU GAUGAGGCCG AAAGGCCGAA AAUAAUUU 38 INFORMATION FOR SEQ ID NO:2018: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2018: UAUUAGGUAA UGAAUUG 17 452 INFORMATION FOR SEQ ID NO:2019: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2019: CAAUUCAUCU GAUGAGGCCG AAAGGCCGAA ACCUAAUA 38 INFORMATION FOR SEQ ID NO:2020: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2020: UAAUGAAUUG UGACCAU 17 INFORMATION FOR SEQ ID NO:2021: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2021: AUGGUCACCU GAUGAGGCCG AAAGGCCGAA AUUCAUUA 38 INFORMATION FOR SEQ ID NO:2022: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid :V00* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2022: GUGACCAUUU GUUAAUA 17 INFORMATION FOR SEQ ID N0:2023: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2023: UAUUAACACU GAUGAGGCCG AAAGGCCGAA AUGGUCAC 38 INFORMATION FOR SEQ ID NO:2024: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2024: +53 UGACCAUUUG UUAAUAU 17 INFORMATION FOR SEQ ID NO:2025: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2025: AUAUUAACCU GAUGAGGCCG AAAGGCCGAA AAUGGUCA 38 INFORMATION FOR SEQ ID NO:2026: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2026: CCAUUUGUUA AUAUCAU 17 S(2) INFORMATION FOR SEQ ID NO:2027: SEQUENCE CHARACTERISTICS: S* LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2027: SAUGAUAUUCU GAUGAGGCCG AAAGGCCGAA ACAAAUGG 38 3 8 INFORMATION FOR SEQ ID NO:2028: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2028: o*oi CAUUUGUUAA UAUCAUA 17 INFORMATION FOR SEQ ID NO:2029: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2029: UAUGAUAUCU GAUGAGGCCG AAAGGCCGAA AACAAAUG 38 INFORMATION FOR SEQ ID NO:2030: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 454 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2030: UUGUUAAUAU CAUAAUC 17 INFORMATION FOR SEQ ID NO:2031: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2031: GAUUAUGACU GAUGAGGCCG AAAGGCCGAA AUUAACAA 38 INFORMATION FOR SEQ ID NO:2032: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2032: GUUAAUAUCA UAAUCAG 17 INFORMATION FOR SEQ ID NO:2033: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2033: CUGAUUAUCU GAUGAGGCCG AAAGGCCGAA AUAUUAAC 38 INFORMATION FOR SEQ ID NO:2034: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2034: AAUAUCAUAA UCAGAUU 17 INFORMATION FOR SEQ ID NO:2035: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2035: AAUCUGAUCU GAUGAGGCCG AAAGGCCGAA AUGAUAUU 38 INFORMATION FOR SEQ ID NO:2036: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2036: AUCAUAAUCA GAUUUUU 17 INFORMATION FOR SEQ ID NO:2037: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2037: AAAAAUCUCU GAUGAGGCCG AAAGGCCGAA AUUAUGAU 38 INFORMATION FOR SEQ ID NO:2038: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2038: AAUCAGAUUU UUUAAAA 17 INFORMATION FOR SEQ ID NO:2039: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2039: UUUUAAAACU GAUGAGGCCG AAAGGCCGAA AUCUGAUU 38 INFORMATION FOR SEQ ID NO:2040: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2040: AUCAGAUUUU UUAAAAA 17 INFORMATION FOR SEQ ID NO:2041: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2041: UUUUUAAACU GAUGAGGCCG AAAGGCCGAA AAUCUGAU 38 INFORMATION FOR SEQ ID NO:2042: 456 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2042: UCAGAUUUUU UAAAAAA 17 INFORMATION FOR SEQ ID NO:2043: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2043: UUUUUUAACU GAUGAGGCCG AAAGGCCGAA AAAUCUGA 38 INFORMATION FOR SEQ ID NO:2044: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2044: CAGAUUUUUU AAAAAAA 17 INFORMATION FOR SEQ ID NO:2045: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2045: UUUUUUUACU GAUGAGGCCG AAAGGCCGAA AAAAUCUG 38 INFORMATION FOR SEQ ID NO:2046: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2046: AGAUUUUUUA AAAAAAA 17 INFORMATION FOR SEQ ID NO:2047: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2047: UUUUUUUUCU GAUGAGGCCG AAAGGCCGAA AAAAAUCU 38 INFORMATION FOR SEQ ID NO:2048: 457 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2048: GAUUUUUuAA AAAAAAU 17 INFORMATION FOR SEQ ID NO:2049: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2049: AUUUUUUUCU GAUGAGGCCG AAAGGCCGAA AAAAAAUC 38 INFORMATION FOR SEQ ID NO:2050: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S* TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2050: AAAAAAAUAA AAUGAUU 17 INFORMATION FOR SEQ ID NO:2051: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear .9.o (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2051: AAUCAUUUCU GAUGAGGCCG AAAGGCCGAA AUUUUUUU 38 *9 INFORMATION FOR SEQ ID NO:2052: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2052: AAAAUGAUUU AUUUGUA 17 INFORMATION FOR SEQ ID NO:2053: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2053: UACAAAUACU GAUGAGGCCG AAAGGCCGAA AUCAUUUU INFORMATION FOR SEQ ID NO:2054: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2054: AAAUGAUUUA UUUGUAU 17 INFORMATION FOR SEQ ID NO:2055: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2055: AUACAAAUCU GAUGAGGCCG AAAGGCCGAA AAUCAUUU 38 INFORMATION FOR SEQ ID NO:2056: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2056: AAUGAUUUAU UUGUAUU 17 INFORMATION FOR SEQ ID NO:2057: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2057: SAAUACAAACU GAUGAGGCCG AAAGGCCGAA AAAUCAUU 38 INFORMATION FOR SEQ ID NO:2058: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2058: UGAUUUAUUU GUAUUUU 17 INFORMATION FOR SEQ ID NO:2059: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2059: AAAAUACACU GAUGAGGCCG AAAGGCCGAA AUAAAUCA 38 INFORMATION FOR SEQ ID NO:2060: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2060: GAUUUAUUUG UAUUUUA 17 INFORMATION FOR SEQ ID NO:2061: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2061: S. UAAAAUACCU GAUGAGGCCG AAAGGCCGAA AAUAAAUC 38 INFORMATION FOR SEQ ID NO:2062: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2062: UUAUUUGUAU UUUAGAG 17 INFORMATION FOR SEQ ID NO:2063: SEQUENCE CHARACTERISTICS: **oo LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2063: CUCUAAAACU GAUGAGGCCG AAAGGCCGAA ACAAAUAA 38 INFORMATION FOR SEQ ID NO:2064: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2064: AUUUGUAUUU UAGAGAA 17 INFORMATION FOR SEQ ID NO:2065: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2065: UUCUCUAACU GAUGAGGCCG AAAGGCCGAA AUACAAAU 38 INFORMATION FOR SEQ ID NO:2066: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2066: UUUGUAUUUU AGAGAAU 17 INFORMATION FOR SEQ ID NO:2067: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2067: AUUCUCUACU GAUGAGGCCG AAAGGCCGAA AAUACAAA 38 INFORMATION FOR SEQ ID NO:2068: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2068: UUGUAUUUUA GAGAAUA 17 INFORMATION FOR SEQ ID NO:2069: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:2069: UAUUCUCUCU GAUGAGGCCG AAAGGCCGAA AAAUACAA 38 INFORMATION FOR SEQ ID NO:2070: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2070: UGUAUUUUAG AGAAUAC 17 INFORMATION FOR SEQ ID NO:2071: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2071: GUAUUCUCCU GAUGAGGCCG AAAGGCCGAA AAAAUACA 38 INFORMATION FOR SEQ ID NO:2072: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2072: UAGAGAAUAC AACAGAU 17 INFORMATION FOR SEQ ID NO:2073: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2073: AUCUGUUGCU GAUGAGGCCG AAAGGCCGAA AUUCUCUA 38 INFORMATION FOR SEQ ID NO:2074: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2074: CAACAGAUCA GUAUUUU 17 INFORMATION FOR SEQ ID NO:2075: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2075: AAAAUACUCU GAUGAGGCCG AAAGGCCGAA AUCUGUUG 38 INFORMATION FOR SEQ ID NO:2076: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2076: AGAUCAGUAU UUUUGAC 17 INFORMATION FOR SEQ ID NO:2077: SEQUENCE CHARACTERISTICS: W LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2077: GUCAAAAACU GAUGAGGCCG AAAGGCCGAA ACUGAUCU 38 INFORMATION FOR SEQ ID NO:2078: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2078: AUCAGUAUUU UUGACUG 17 INFORMATION FOR SEQ ID NO:2079: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2079: CAGUCAAACU GAUGAGGCCG AAAGGCCGAA AUACUGAU 38 INFORMATION FOR SEQ ID NO:2080: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2080: UCAGUAUUUU UGACUGU 17 17 INFORMATION FOR SEQ ID NO:2081: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2081: ACAGUCAACU GAUGAGGCCG AAAGGCCGAA AAUACUGA 38 INFORMATION FOR SEQ ID NO:2082: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2082: CAGUAUUUUU GACUGUG 1- INFORMATION FOR SEQ ID NO:2083: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2083: CACAGUCACU GAUGAGGCCG AAAGGCCGAA AAAUACUG 38 INFORMATION FOR SEQ ID NO:2084: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2084: AGUAUUUUUG ACUGUGG 17 INFORMATION FOR SEQ ID NO:2085: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2085: CCACAGUCCU GAUGAGGCCG AAAGGCCGAA AAAAUACU 38 INFORMATION FOR SEQ ID NO:2086: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2086: UGGUGAAUUU AAAAAAA 17 INFORMATION FOR SEQ ID NO:2087: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2087: UUUUUUUACU GAUGAGGCCG AAAGGCCGAA AUUCACCA 38 INFORMATION FOR SEQ ID NO:2088: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2088: GGUGAAUUUA AAAAAAA 17 4 4- INFORMATION FOR SEQ ID NO:2089: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2089: UUUUUUUUCU GAUGAGGCCG AAAGGCCGAA AAUUCACC 38 INFORMATION FOR SEQ ID NO:2090: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2090: GUGAAUUUAA AAAAAAA **17 INFORMATION FOR SEQ ID NO:2091: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2091: UUUUUUUUCU GAUGAGGCCG AAAGGCCGAA AAAUUCAC 38 INFORMATION FOR SEQ ID NO:2092: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2092: AAAAAAAUUU ACACAAA 17 INFORMATION FOR SEQ ID NO:2093: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2093: UUUGUGUACU GAUGAGGCCG AAAGGCCGAA AUUUUUUU 38 INFORMATION FOR SEQ ID NO:2094: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2094: AAAAAAUUUA CACAAAG 17 INFORMATION FOR SEQ ID NO:2095: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2095: CUUUGUGUCU GAUGAGGCCG AAAGGCCGAA AAUUUUUU 38 INFORMATION FOR SEQ ID NO:2096: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2096: AAAAAUUUAC ACAAAGA 17 INFORMATION FOR SEQ ID NO:2097: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2097: UCUUUGUGCU GAUGAGGCCG AAAGGCCGAA AAAUUUUU 38 INFORMATION FOR SEQ ID NO:2098: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2098: AAAGAAAUAU CCCAGUA 17 INFORMATION FOR SEQ ID NO:2099: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2099: UACUGGGACU GAUGAGGCCG AAAGGCCGAA AUUUCUUU 38 INFORMATION FOR SEQ ID NO:2100: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2100: AGAAAUAUCC CAGUAUU 17 INFORMATION FOR SEQ ID NO:2101: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2101: AAUACUGGCU GAUGAGGCCG AAAGGCCGAA AUAUUUCU 38 INFORMATION FOR SEQ ID NO:2102: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2102: AUCCCAGUAU UCCAUGU 17 INFORMATION FOR SEQ ID NO:2103: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2103: ACAUGGAACU GAUGAGGCCG AAAGGCCGAA ACUGGGAU 38 INFORMATION FOR SEQ ID NO:2104: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2104: CCCAGUAUUC CAUGUAU 17 INFORMATION FOR SEQ ID NO:2105: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2105: AUACAUGGCU GAUGAGGCCG AAAGGCCGAA AUACUGGG 38 INFORMATION FOR SEQ ID NO:2106: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single 4-67 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2106: CCAGUAUUCC AUGUAUC 17 INFORMATION FOR SEQ ID NO:2107: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2107: GAUACAUGCU GAUGAGGCCG AAAGGCCGAA AAUACUGG 38 INFORMATION FOR SEQ ID NO:2108: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2108: UUCCAUGUAU CUCAGUC 17 9: INFORMATION FOR SEQ ID NO:2109: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2109: GACUGAGACU GAUGAGGCCG AAAGGCCGAA ACAUGGAA 38 INFORMATION FOR SEQ ID NO:2110: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2110: CCAUGUAUCU CAGUCAC 17 INFORMATION FOR SEQ ID NO:2111: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2111: GUGACUGACU GAUGAGGCCG AAAGGCCGAA AUACAUGG 38 INFORMATION FOR SEQ ID NO:2112: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2112: AUGUAUCUCA GUCACUA 17 INFORMATION FOR SEQ ID NO:2113: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2113: UAGUGACUCU GAUGAGGCCG AAAGGCCGAA AGAUACAU 38 INFORMATION FOR SEQ ID NO:2114: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2114: AUCUCAGUCA CUAAACA 17 INFORMATION FOR SEQ ID NO:2115: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2115: UGUUUAGUCU GAUGAGGCCG AAAGGCCGAA ACUGAGAU 38 INFORMATION FOR SEQ ID NO:2116: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2116: CAGUCACUAA ACAUACA 17 INFORMATION FOR SEQ ID NO:2117: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2117: UGUAUGUUCU GAUGAGGCCG AAAGGCCGAA AGUGACUG 38 INFORMATION FOR SEQ ID NO:2118: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2118: CUAAACAUAC ACAGAGA 17 INFORMATION FOR SEQ ID NO:2119: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2119: UCUCUGUGCU GAUGAGGCCG AAAGGCCGAA AUGUUUAG 38 INFORMATION FOR SEQ ID NO:2120: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single o, TOPOLOGY: linear S* S (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2120: AGAGAGAUUU UUAAAAA 17 INFORMATION FOR SEQ ID NO:2121: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2121: UUUUUAAACU GAUGAGGCCG AAAGGCCGAA AUCUCUCU 38 t INFORMATION FOR SEQ ID NO:2122: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2122: GAGAGAUUUU UAAAAAC 17 INFORMATION FOR SEQ ID NO:2123: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2123: GUUUUUAACU GAUGAGGCCG AAAGGCCGAA AAUCUCUC 38 INFORMATION FOR SEQ ID NO:2124: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2124: AGAGAUUUUU AAAAACC 17 INFORMATION FOR SEQ ID NO:2125: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2125: GGUUUUUACU GAUGAGGCCG AAAGGCCGAA AAAUCUCU 38 INFORMATION FOR SEQ ID NO:2126: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2126: GAGAUUUUUA AAAACCA 17 INFORMATION FOR SEQ ID NO:2127: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single *e TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2127: UGGUUUUUCU GAUGAGGCCG AAAGGCCGAA AAAAUCUC 38 INFORMATION FOR SEQ ID NO:2128: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2128: AGAUUUUUAA AAACCAG 17 INFORMATION FOR SEQ ID NO:2129: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2129: 4-71 CUGGUUUUCU GAUGAGGCCG AAAGGCCGAA AAAAAUCU 38 INFORMATION FOR SEQ ID NO:2130: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2130: AGAAGCAUUA UUUUGAA 17 INFORMATION FOR SEQ ID NO:2131: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2131: UUCAAAAUCU GAUGAGGCCG AAAGGCCGAA AUGCUUCU 38 INFORMATION FOR SEQ ID NO:2132: fee*: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2132: GAAGCAUUAU UUUGAAU 17 INFORMATION FOR SEQ ID NO:2133: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2133: AUUCAAAACU GAUGAGGCCG AAAGGCCGAA AAUGCUUC 38 INFORMATION FOR SEQ ID N0:2134: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2134: AGCAUUAUUU UGAAUGU 17 INFORMATION FOR SEQ ID NO:2135: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 4-72 0.

9 9 9 9 9999* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2135: ACAUUCAACU GAUGAGGCCG AAAGGCCGAA AUAAUGCU INFORMATION FOR SEQ ID NO:2136: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2136: GCAUUAUU U GAAUGUU INFORMATION FOR SEQ ID NO:2137: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2137: AACAUUCACU GAUGAGGCCG AAAGGCCGAA AAUAAUGC INFORMATION FOR SEQ ID NO:2138: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2138: CAUUAUUUUG AAUGUUA INFORMATION FOR SEQ ID NO:2139: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2139: UAACAUUCCU GAUGAGGCCG AAAGGCCGAA AAAUAAUG INFORMATION FOR SEQ ID NO:2140: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2140: UUGAAUGUUA GCUAAAU INFORMATION FOR SEQ ID NO:2141: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid 4-7, a.

0 a STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2141: AUUUAGCUCU GAUGAGGCCG AAAGGCCGAA ACAUUCAA INFORMATION FOR SEQ ID NO:2142: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2142: UGAAUGUUAG CUAAAUC INFORMATION FOR SEQ ID NO:2143: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2143: GAUUUAGCCU GAUGAGGCCG AAAGGCCGAA AACAUUCA INFORMATION FOR SEQ ID NO:2144: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2144: UGUUAGCUAA AUCCCAA INFORMATION FOR SEQ ID NO:2145: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2145: UUGGGAUUCU GAUGAGGCCG AAAGGCCGAA AGCUAACA INFORMATION FOR SEQ ID NO:2146: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2146: AGCUAAAUCC CAAGUAA INFORMATION FOR SEQ ID NO:2147: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2147: UUACUUGGCU GAUGAGGCCG AAAGGCCGAA AUUUAGCU 38 INFORMATION FOR SEQ ID NO:2148: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2148: UCCCAAGUAA UACUUAA 17 INFORMATION FOR SEQ ID NO:2149: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2149: UUAAGUAUCU GAUGAGGCCG AAAGGCCGAA ACUUGGGA 38 INFORMATION FOR SEQ ID NO:2150: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2150: CAAGUAAUAC UUAAUGC 17 0* 17 INFORMATION FOR SEQ ID NO:2151: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2151: GCAUUAAGCU GAUGAGGCCG AAAGGCCGAA AUUACUUG 38 INFORMATION FOR SEQ ID NO:2152: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2152: GUAAUACUUA AUGCAAC 17 INFORMATION FOR SEQ ID NO:2153: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2153: GUUGCAUUCU GAUGAGGCCG AAAGGCCGAA AGUAUUAC 38 INFORMATION FOR SEQ ID NO:2154: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2154: UAAUACUUAA UGCAACC 17 INFORMATION FOR SEQ ID NO:2155: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2155: GGUUGCAUCU GAUGAGGCCG AAAGGCCGAA AAGUAUUA 38 INFORMATION FOR SEQ ID NO:2156: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2156: GCAACCCUCU AGGAGCU 17 INFORMATION FOR SEQ ID NO:2157: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2157: AGCUCCUACU GAUGAGGCCG AAAGGCCGAA AGGGUUGC 38 INFORMATION FOR SEQ ID NO:2158: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2158: AACCCUCUAG GAGCUCA +76 INFORMATION FOR SEQ ID NO:2159: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2159: UGAGCUCCCU GAUGAGGCCG AAAGGCCGAA AGAGGGUU 38 INFORMATION FOR SEQ ID NO:2160: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2160: UAGGAGCUCA UUUGUGG 17 INFORMATION FOR SEQ ID NO:2161: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2161: CCACAAAUCU GAUGAGGCCG AAAGGCCGAA AGCUCCUA 38 INFORMATION FOR SEQ ID NO:2162: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2162: GAGCUCAUUU GUGGCUA 17 INFORMATION FOR SEQ ID NO:2163: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2163: UAGCCACACU GAUGAGGCCG AAAGGCCGAA AUGAGCUC 38 INFORMATION FOR SEQ ID NO:2164: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2164:

I

4-77 AGCUCAUUUG UGGCUAA 17 INFORMATION FOR SEQ ID NO:2165: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2165: UUAGCCACCU GAUGAGGCCG AAAGGCCGAA AAUGAGCU 38 INFORMATION FOR SEQ ID NO:2166: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2166: SUUGUGGCUAA UAAUCUU 17 INFORMATION FOR SEQ ID NO:2167: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2167: SAAGAUUAUCU GAUGAGGCCG AAAGGCCGAA AGCCACAA 38 INFORMATION FOR SEQ ID NO:2168: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2168: UGGCUAAUAA UCUUGGA 17 INFORMATION FOR SEQ ID NO:2169: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2169: UCCAAGAUCU GAUGAGGCCG AAAGGCCGAA AUUAGCCA 38 INFORMATION FOR SEQ ID NO:2170: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2170: CUAAUAAUCU UGGAAAU 17 INFORMATION FOR SEQ ID NO:2171: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2171: AUUUCCAACU GAUGAGGCCG AAAGGCCGAA AUUAUUAG 38 INFORMATION FOR SEQ ID NO:2172: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2172: AAUAAUCUUG GAAAUAU 17 INFORMATION FOR SEQ ID NO:2173: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2173: AUAUUUCCCU GAUGAGGCCG AAAGGCCGAA AGAUUAUU 38 INFORMATION FOR SEQ ID NO:2174: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2174: UUGGAAAUAU CUUUAUU 17 INFORMATION FOR SEQ ID NO:2175: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2175: AAUAAAGACU GAUGAGGCCG AAAGGCCGAA AUUUCCAA 38 INFORMATION FOR SEQ ID NO:2176: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2176: GGAAAUAUCU UUAUUAU 17 INFORMATION FOR SEQ ID NO:2177: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2177: AUAAUAAACU GAUGAGGCCG AAAGGCCGAA AUAUUUCC 38 INFORMATION FOR SEQ ID NO:2178: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2178: *AAAUAUCUUU AUUAUAU 17 INFORMATION FOR SEQ ID NO:2179: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2179: S AUAUAAUACU GAUGAGGCCG AAAGGCCGAA AGAUAUUU 38 INFORMATION FOR SEQ ID NO:2180: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2180: AAUAUCUUUA UUAUAUA 17 INFORMATION FOR SEQ ID NO:2181: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2181: UAUAUAAUCU GAUGAGGCCG AAAGGCCGAA AAGAUAUU 38 INFORMATION FOR SEQ ID NO:2182: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2182: AUAUCUUUAU UAUAUAG 17 INFORMATION FOR SEQ ID NO:2183: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2183: CUAUAUAACU GAUGAGGCCG AAAGGCCGAA AAAGAUAU 38 INFORMATION FOR SEQ ID NO:2184: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2184: AUCUUUAUUA UAUAGCA 17 INFORMATION FOR SEQ ID NO:2185: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2185: UGCUAUAUCU GAUGAGGCCG AAAGGCCGAA AUAAAGAU 38 INFORMATION FOR SEQ ID NO:2186: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2186: UCUUUAUUAU AUAGCAU 17 INFORMATION FOR SEQ ID NO:2187: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2187: AUGCUAUACU GAUGAGGCCG AAAGGCCGAA AAUAAAGA

-R

41 INFORMATION FOR SEQ ID NO:2188: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2188: UUUAUUAUAU AGCAUUU 17 INFORMATION FOR SEQ ID NO:2189: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2189: AAAUGCUACU GAUGAGGCCG AAAGGCCGAA AUAAUAAA 38 INFORMATION FOR SEQ ID NO:2190: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2190: UAUUAUAUAG CAUUUAU 17 INFORMATION FOR SEQ ID NO:2191: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2191: AUAAAUGCCU GAUGAGGCCG AAAGGCCGAA AUAUAAUA 38 9 INFORMATION FOR SEQ ID NO:2192: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2192: UAUAGCAUUU AUGAGGA INFORMATION FOR SEQ ID NO:2193: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2193: UCCUCAUACU GAUGAGGCCG AAAGGCCGAA AUGCUAUA INFORMATION FOR SEQ ID NO:2194: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2194: AUAGCAUUUA UGAGGAG 17 INFORMATION FOR SEQ ID NO:2195: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2195: CUCCUCAUCU GAUGAGGCCG AAAGGCCGAA AAUGCUAU 38 S(2) INFORMATION FOR SEQ ID NO:2196: SEQUENCE CHARACTERISTICS: 0 "0 LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2196: S UAGCAUUUAU

GAGGAGA

17 INFORMATION FOR SEQ ID NO:2197: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid los STRANDEDNESS: single TOPOLOGY: linear S (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2197: SUCUCCUCACU GAUGAGGCCG AAAGGCCGAA AAAUGCUA 38 INFORMATION FOR SEQ ID NO:2198: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2198: GAGGAGAUUU UGUUGUC 17 INFORMATION FOR SEQ ID NO:2199: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2199: GACAACAACU GAUGAGGCCG AAAGGCCGAA AUCUCCUC 38 INFORMATION FOR SEQ ID NO:2200: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2200: AGGAGAUUUU GUUGUCA 17 INFORMATION FOR SEQ ID NO:2201: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2201: S UGACAACACU GAUGAGGCCG AAAGGCCGAA AAUCUCCU 38 INFORMATION FOR SEQ ID NO:2202: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2202: GGAGAUUUUG UUGUCAG 17 INFORMATION FOR SEQ ID NO:2203: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2203: CUGACAACCU GAUGAGGCCG AAAGGCCGAA AAAUCUCC 38 INFORMATION FOR SEQ ID NO:2204: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2204: GAUUUUGUUG UCAGCUU 17 INFORMATION FOR SEQ ID NO:2205: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear +4 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2205: AAGCUGACCU GAUGAGGCCG AAAGGCCGAA ACAAAAUC 38 INFORMATION FOR SEQ ID NO:2206: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2206: UUUGUUGUCA GCUUGCU 17 INFORMATION FOR SEQ ID NO:2207: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear f (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2207: AGCAAGCUCU GAUGAGGCCG AAAGGCCGAA ACAACAAA 38 INFORMATION FOR SEQ ID NO:2208: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2208: UGUCAGCUUG CUUGAAA 17 INFORMATION FOR SEQ ID NO:2209: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2209: UUUCAAGCCU GAUGAGGCCG AAAGGCCGAA AGCUGACA 38 INFORMATION FOR SEQ ID NO:2210: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2210: AGCUUGCUUG AAAGUUA 17 INFORMATION FOR SEQ ID NO:2211: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 435 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2211: UAACUUUCCU GAUGAGGCCG AAAGGCCGAA AGCAAGCU 38 INFORMATION FOR SEQ ID NO:2212: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2212: UUGAAAGUUA UUAUGUA 17 INFORMATION FOR SEQ ID NO:2213: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2213: UACAUAAUCU GAUGAGGCCG AAAGGCCGAA ACUUUCAA 38 INFORMATION FOR SEQ ID NO:2214: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2214: UGAAAGUUAU UAUGUAU 17 INFORMATION FOR SEQ ID NO:2215: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2215: AUACAUAACU GAUGAGGCCG AAAGGCCGAA AACUUUCA 38 INFORMATION FOR SEQ ID NO:2216: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:2216: AAAGUUAUUA UGUAUGA 17 INFORMATION FOR SEQ ID NO:2217: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2217: UCAUACAUCU GAUGAGGCCG AAAGGCCGAA AUAACUUU 38 INFORMATION FOR SEQ ID NO:2218: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2218: AAGUUAUUAU GUAUGAA 17 INFORMATION FOR SEQ ID NO:2219: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2219: UUCAUACACU GAUGAGGCCG AAAGGCCGAA AAUAACUU 38 INFORMATION FOR SEQ ID NO:2220: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2220: UAUUAUGUAU

GAAUAGU

17 INFORMATION FOR SEQ ID NO:2221: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2221: ACUAUUCACU GAUGAGGCCG AAAGGCCGAA ACAUAAUA 38 INFORMATION FOR SEQ ID NO:2222: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2222: GUAUGAAUAG

UUUUAUU

17 INFORMATION FOR SEQ ID N0:2223: 487 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2223: AAUAAAACCU GAUGAGGCCG AAAGGCCGAA AUUCAUAC 38 INFORMATION FOR SEQ ID NO:2224: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2224: UGAAUAGUUU UAUUGAA 17 INFORMATION FOR SEQ ID NO:2225: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2225: UUCAAUAACU GAUGAGGCCG AAAGGCCGAA ACUAUUCA 38 INFORMATION FOR SEQ ID NO:2226: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2226: GAAUAGUUUU AUUGAAA 17 INFORMATION FOR SEQ ID NO:2227: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2227: UUUCAAUACU GAUGAGGCCG AAAGGCCGAA AACUAUUC 38 INFORMATION FOR SEQ ID NO:2228: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2228: AAUAGUUUUA UUGAAAA INFORMATION FOR SEQ ID NO:2229: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2229: UUUUCAAUCU GAUGAGGCCG AAAGGCCGAA AAACUAUU 38 INFORMATION FOR SEQ ID NO:2230: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2230: AUAGUUUUAU UGAAAAA 17 INFORMATION FOR SEQ ID NO:2231: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2231: UUUUUCAACU GAUGAGGCCG AAAGGCCGAA AAAACUAU 38 INFORMATION FOR SEQ ID NO:2232: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2232: SAGUUUUAUUG AAAAAAU 17 INFORMATION FOR SEQ ID NO:2233: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2233: AUUUUUUCCU GAUGAGGCCG AAAGGCCGAA AUAAAACU 38 INFORMATION FOR SEQ ID NO:2234: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2234: GAAAAAAUUA UAUUUUU 17 INFORMATION FOR SEQ ID NO:2235: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2235: AAAAAUAUCU GAUGAGGCCG AAAGGCCGAA AUUUUUUC 38 INFORMATION FOR SEQ ID NO:2236: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2236: .AAAAAAUAU AUUUUUA 17 INFORMATION FOR SEQ ID NO:2237: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2237: UAAAAAUACU GAUGAGGCCG AAAGGCCGAA AAUUUUUU 38 INFORMATION FOR SEQ ID NO:2238: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 4° (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2238: AAAAUUAUAU UUUUAUU 17 INFORMATION FOR SEQ ID NO:2239: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2239: AAUAAAAACU GAUGAGGCCG AAAGGCCGAA AUAAUUUU 38 INFORMATION FOR SEQ ID NO:2240: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2240: AAUUAUAUUU UUAUUCA INFORMATION FOR SEQ ID NO:2241: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2241: UGAAUAAACU GAUGAGGCCG AAAGGCCGAA AUAUAAUU 38 INFORMATION FOR SEQ ID NO:2242: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear :0 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2242: S AUUAUAUUUU UAUUCAG 17 INFORMATION FOR SEQ ID NO:2243: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2243: CUGAAUAACU GAUGAGGCCG AAAGGCCGAA AAUAUAAU 38 3 INFORMATION FOR SEQ ID NO:2244: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2244: UUAUAUUUUU AUUCAGU 17 INFORMATION FOR SEQ ID NO:2245: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2245: ACUGAAUACU GAUGAGGCCG AAAGGCCGAA AAAUAUAA 38 INFORMATION FOR SEQ ID NO:2246: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2246: UAUAUUUUUA UUCAGUA 17 INFORMATION FOR SEQ ID NO:2247: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2247: UACUGAAUCU GAUGAGGCCG AAAGGCCGAA AAAAUAUA 38 INFORMATION FOR SEQ ID NO:2248: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2248: AUAUUUUUAU UCAGUAA 17 INFORMATION FOR SEQ ID NO:2249: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2249: UUACUGAACU GAUGAGGCCG AAAGGCCGAA AAAAAUAU 38 INFORMATION FOR SEQ ID NO:2250: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2250: AUUUUUAUUC AGUAAUU 17 INFORMATION FOR SEQ ID NO:2251: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2251: AAUUACUGCU GAUGAGGCCG AAAGGCCGAA AUAAAAAU 38 INFORMATION FOR SEQ ID NO:2252: 4-q2 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2252: UUUUUAUUCA GUAAUUU 17 INFORMATION FOR SEQ ID NO:2253: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2253: AAAUUACUCU GAUGAGGCCG AAAGGCCGAA AAUAAAAA 38 INFORMATION FOR SEQ ID NO:2254: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2254: 9* UAUUCAGUAA UUUAAUU 17 INFORMATION FOR SEQ ID NO:2255: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2255: AAUUAAAUCU GAUGAGGCCG AAAGGCCGAA ACUGAAUA 38 S(2) INFORMATION FOR SEQ ID NO:2256: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2256: UCAGUAAUUU AAUUUUG 17 INFORMATION FOR SEQ ID NO:2257: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2257: CAAAAUUACU GAUGAGGCCG AAAGGCCGAA AUUACUGA 38 INFORMATION FOR SEQ ID NO:2258: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2258: CAGUAAUUUA AUUUUGU 17 INFORMATION FOR SEQ ID NO:2259: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2259: ACAAAAUUCU GAUGAGGCCG AAAGGCCGAA AAUUACUG 38 INFORMATION FOR SEQ ID NO:2260: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2260: AGUAAUUUAA UUUUGUA 17 INFORMATION FOR SEQ ID NO:2261: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear e (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2261: o. UACAAAAUCU GAUGAGGCCG AAAGGCCGAA AAAUUACU 38 INFORMATION FOR SEQ ID NO:2262: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2262: AAAUUAAUUU UGUAAAU 17 INFORMATION FOR SEQ ID NO:2263: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2263: AUUUACAACU GAUGAGGCCG AAAGGCCGAA AUUAAAUU 1o 4- 4 INFORMATION FOR SEQ ID NO:2264: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2264: AUUUAAUUUU GUAAAUG 17 INFORMATION FOR SEQ ID NO:2265: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2265: CAUUUACACU GAUGAGGCCG AAAGGCCGAA AAUUAAAU 38 INFORMATION FOR SEQ ID NO:2266: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2266: UUUAAUUUUG UAAAUGC 17 INFORMATION FOR SEQ ID NO:2267: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2267: GCAUUUACCU GAUGAGGCCG AAAGGCCGAA AAAUUAAA 38 INFORMATION FOR SEQ ID NO:2268: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2268: AAUUUUGUAA AUGCCAA 17 INFORMATION FOR SEQ ID NO:2269: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2269: UUGGCAUUCU GAUGAGGCCG AAAGGCCGAA ACAAAAUU 38 INFORMATION FOR SEQ ID NO:2270: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2270: AAAUGUGUUC GCUGCUA 17 INFORMATION FOR SEQ ID NO:2271: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2271: UAGCAGCGCU GAUGAGGCCG AAAGGCCGAA ACACAUUU 38 INFORMATION FOR SEQ ID NO:2272: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2272: AAUGUGUUCG CUGCUAU 17 INFORMATION FOR SEQ ID NO:2273: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2273: AUAGCAGCCU GAUGAGGCCG AAAGGCCGAA AACACAUU 38 INFORMATION FOR SEQ ID NO:2274: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2274: UCGCUGCUAU GGUUUUA 17 INFORMATION FOR SEQ ID NO:2275: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2275: UAAAACCACU GAUGAGGCCG AAAGGCCGAA AGCAGCGA 38 INFORMATION FOR SEQ ID NO:2276: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2276: GCUAUGGUUU UAGCCUA 17 INFORMATION FOR SEQ ID NO:2277: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 0, (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2277: UAGGCUAACU GAUGAGGCCG AAAGGCCGAA ACCAUAGC 38 INFORMATION FOR SEQ ID NO:2278: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear **00 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2278: CUAUGGUUUU AGCCUAU 17 INFORMATION FOR SEQ ID NO:2279: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2279: AUAGGCUACU GAUGAGGCCG AAAGGCCGAA AACCAUAG 38 INFORMATION FOR SEQ ID NO:2280: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2280: UAUGGUUUUA GCCUAUA 17 INFORMATION FOR SEQ ID NO:2281: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 4-q 7 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2281: UAUAGGCUCU GAUGAGGCCG AAAGGCCGAA AAACCAUA 38 INFORMATION FOR SEQ ID NO:2282: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2282: AUGGUUUUAG CCUAUAG 17 INFORMATION FOR SEQ ID NO:2283: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear ooo (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2283: SCUAUAGGCCU GAUGAGGCCG AAAGGCCGAA AAAACCAU 38 INFORMATION FOR SEQ ID NO:2284: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2284: UUUAGCCUAU AGUCAUG 17 INFORMATION FOR SEQ ID NO:2285: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2285: CAUGACUACU GAUGAGGCCG AAAGGCCGAA AGGCUAAA 38 INFORMATION FOR SEQ ID NO:2286: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2286: UAGCCUAUAG UCAUGCU 17 INFORMATION FOR SEQ ID NO:2287: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2287: AGCAUGACCU GAUGAGGCCG AAAGGCCGAA AUAGGCUA 38 INFORMATION FOR SEQ ID NO:2288: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2288: CCUAUAGUCA UGCUGCU 17 INFORMATION FOR SEQ ID NO:2289: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2289: AGCAGCAUCU GAUGAGGCCG AAAGGCCGAA ACUAUAGG 38 INFORMATION FOR SEQ ID NO:2290: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2290: S AUGCUGCUAG CUAGUGU 17 INFORMATION FOR SEQ ID NO:2291: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2291: ACACUAGCCU GAUGAGGCCG AAAGGCCGAA AGCAGCAU 38 INFORMATION FOR SEQ ID NO:2292: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2292: UGCUAGCUAG UGUCAGG INFORMATION FOR SEQ ID NO:2293: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2293: CCUGACACCU GAUGAGGCCG AAAGGCCGAA AGCUAGCA 38 INFORMATION FOR SEQ ID NO:2294: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2294: GCUAGUGUCA GGGGGCA 17 9 INFORMATION FOR SEQ ID NO:2295: SEQUENCE CHARACTERISTICS: S* LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2295: UGCCCCCUCU GAUGAGGCCG AAAGGCCGAA ACACUAGC 38 INFORMATION FOR SEQ ID NO:2296: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2296: GGGGCAAUAG AGCUUAG 17 INFORMATION FOR SEQ ID NO:2297: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2297: CUAAGCUCCU GAUGAGGCCG AAAGGCCGAA AUUGCCCC 38 INFORMATION FOR SEQ ID NO:2298: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2298: AUAGAGCUUA GAUGGAA 17 INFORMATION FOR SEQ ID NO:2299: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2299: UUCCAUCUCU GAUGAGGCCG AAAGGCCGAA AGCUCUAU 38 INFORMATION FOR SEQ ID NO:2300: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2300: UAGAGCUUAG AUGGAAA 17 "4 INFORMATION FOR SEQ ID NO:2301: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2301: UUUCCAUCCU GAUGAGGCCG AAAGGCCGAA AAGCUCUA 38 INFORMATION FOR SEQ ID NO:2302: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2302: AAGAGACUCG GUGUUAG 17 INFORMATION FOR SEQ ID NO:2303: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2303: CUAACACCCU GAUGAGGCCG AAAGGCCGAA AGUCUCUU 38 INFORMATION FOR SEQ ID NO:2304: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2304: CUCGGUGUUA GAUAACG 17 INFORMATION FOR SEQ ID NO:2305: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2305: CGUUAUCUCU GAUGAGGCCG AAAGGCCGAA ACACCGAG 38 INFORMATION FOR SEQ ID NO:2306: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2306: UCGGUGUUAG AUAACGG 17 INFORMATION FOR SEQ ID NO:2307: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2307: CCGUUAUCCU GAUGAGGCCG AAAGGCCGAA AACACCGA 38 INFORMATION FOR SEQ ID NO:2308: *o.o SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2308: UGUUAGAUAA CGGACUA 17 INFORMATION FOR SEQ ID NO:2309: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2309: UAGUCCGUCU GAUGAGGCCG AAAGGCCGAA AUCUAACA 38 INFORMATION FOR SEQ ID NO:2310: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 502 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2310: AACGGACUAU GCACUAG 17 INFORMATION FOR SEQ ID NO:2311: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2311: CUAGUGCACU GAUGAGGCCG AAAGGCCGAA AGUCCGUU 38 INFORMATION FOR SEQ ID NO:2312: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2312: UAUGCACUAG UAUUCCA 17 INFORMATION FOR SEQ ID NO:2313: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2313: UGGAAUACCU GAUGAGGCCG AAAGGCCGAA AGUGCAUA 38 INFORMATION FOR SEQ ID NO:2314: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2314: GCACUAGUAU UCCAGAC 17 INFORMATION FOR SEQ ID NO:2315: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2315: GUCUGGAACU GAUGAGGCCG AAAGGCCGAA ACUAGUGC 38 INFORMATION FOR SEQ ID NO:2316: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single 503 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2316: ACUAGUAUUC CAGACUU 17 INFORMATION FOR SEQ ID NO:2317: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2317: AAGUCUGGCU GAUGAGGCCG AAAGGCCGAA AUACUAGU 38 INFORMATION FOR SEQ ID NO:2318: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:2318: S* CUAGUAUUCC AGACUUU 17 17 INFORMATION FOR SEQ ID NO:2319: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2319: AAAGUCUGCU GAUGAGGCCG AAAGGCCGAA AAUACUAG 38 INFORMATION FOR SEQ ID NO:2320: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid a STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2320: UCCAGACUUU UUUAUUU 17 INFORMATION FOR SEQ ID NO:2321: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2321: AAAUAAAACU GAUGAGGCCG AAAGGCCGAA AGUCUGGA 38 INFORMATION FOR SEQ ID NO:2322: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2322: CCAGACUUUU UUAUUUU 17 INFORMATION FOR SEQ ID NO:2323: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2323: AAAAUAAACU GAUGAGGCCG AAAGGCCGAA AAGUCUGG 38 INFORMATION FOR SEQ ID NO:2324: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2324: CAGACUUUUU UAUUUUU 17 INFORMATION FOR SEQ ID NO:2325: 00 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2325: AAAAAUAACU GAUGAGGCCG AAAGGCCGAA AAAGUCUG 38 INFORMATION FOR SEQ ID NO:2326: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2326: AGACUUUUUU AUUUUUU 17 INFORMATION FOR SEQ ID NO:2327: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2327: AAAAAAUACU GAUGAGGCCG AAAGGCCGAA AAAAGUCU 38 INFORMATION FOR SEQ ID NO:2328: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2328: GACUUUUUUA UUUUUUA 17 INFORMATION FOR SEQ ID NO:2329: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2329: UAAAAAAUCU GAUGAGGCCG AAAGGCCGAA AAAAAGUC 38 INFORMATION FOR SEQ ID NO:2330: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2330: ACUUUUUAU UUUUUAU 17 INFORMATION FOR SEQ ID NO:2331: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2331: SAUAAAAAACU GAUGAGGCCG AAAGGCCGAA AAAAAAGU 38 INFORMATION FOR SEQ ID NO:2332: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2332: UUUUUUAUUU UUUAUAU 17 INFORMATION FOR SEQ ID NO:2333: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2333: AUAUAAAACU GAUGAGGCCG AAAGGCCGAA AUAAAAAA

AA

50(3 INFORMATION FOR SEQ ID NO:2334: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2334: UUUUUAUUUU UUAUAUA 17 INFORMATION FOR SEQ ID NO:2335: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2335: UAUAUAAACU GAUGAGGCCG AAAGGCCGAA AAUAAAAA 38 INFORMATION FOR SEQ ID NO:2336: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2336: SUUUUAUUUUU UAUAUAU 17 INFORMATION FOR SEQ ID NO:2337: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2337: AUAUAUAACU GAUGAGGCCG AAAGGCCGAA AAAUAAAA 38 INFORMATION FOR SEQ ID NO:2338: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2338: UUUAUUUUUU AUAUAUA 17 INFORMATION FOR SEQ ID NO:2339: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2339: 507 UAUAUAUACU GAUGAGGCCG AAAGGCCGAA AAAAUAAA 38 INFORMATION FOR SEQ ID NO:2340: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2340: UUAUUUUUUA UAUAUAU 17 INFORMATION FOR SEQ ID NO:2341: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2341: AUAUAUAUCU GAUGAGGCCG AAAGGCCGAA AAAAAUAA 38 INFORMATION FOR SEQ ID NO:2342: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2342: UAUUUUUUAU AUAUAUG 17 INFORMATION FOR SEQ ID NO:2343: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2343: CAUAUAUACU GAUGAGGCCG AAAGGCCGAA AAAAAAUA 38 INFORMATION FOR SEQ ID NO:2344: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2344: UUUUUUAUAU AUAUGUA 17 INFORMATION FOR SEQ ID NO:2345: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear sog (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2345: UACAUAUACU GAUGAGGCCG AAAGGCCGAA AUAAAAAA 38 INFORMATION FOR SEQ ID NO:2346: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2346: UUUUAUAUAU AUGUACC 17 INFORMATION FOR SEQ ID NO:2347: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2347: GGUACAUACU GAUGAGGCCG AAAGGCCGAA AUAUAAAA 38 INFORMATION FOR SEQ ID NO:2348: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2348: UUAUAUAUAU GUACCUU 17 INFORMATION FOR SEQ ID NO:2349: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2349: AAGGUACACU GAUGAGGCCG AAAGGCCGAA AUAUAUAA 38 INFORMATION FOR SEQ ID NO:2350: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2350: AUAUAUGUAC CUUUUCC 17 INFORMATION FOR SEQ ID NO:2351: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid

C

STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2351: GGAAAAGGCU GAUGAGGCCG AAAGGCCGAA ACAUAUAU 38 INFORMATION FOR SEQ ID NO:2352: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2352: AUGUACCUUU UCCUUUU 17 INFORMATION FOR SEQ ID NO:2353: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2353: AAAAGGAACU GAUGAGGCCG AAAGGCCGAA AGGUACAU 38 INFORMATION FOR SEQ ID NO:2354: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2354: UGUACCUUUU CCUUUUG 17 INFORMATION FOR SEQ ID NO:2355: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2355: CAAAAGGACU GAUGAGGCCG AAAGGCCGAA AAGGUACA 38 INFORMATION FOR SEQ ID NO:2356: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2356: GUACCUUUUC CUUUUGU 17 INFORMATION FOR SEQ ID NO:2357: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2357: ACAAAAGGCU GAUGAGGCCG AAAGGCCGAA AAAGGUAC 38 INFORMATION FOR SEQ ID NO:2358: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2358: UACCUUUUCC UUUUGUC 17 INFORMATION FOR SEQ ID NO:2359: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2359: GACAAAAGCU GAUGAGGCCG AAAGGCCGAA AAAAGGUA 38 INFORMATION FOR SEQ ID NO:2360: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear :0 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2360: CUUUUCCUUU UGUCAAU 17 INFORMATION FOR SEQ ID NO:2361: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2361: AUUGACAACU GAUGAGGCCG AAAGGCCGAA AGGAAAAG 38 INFORMATION FOR SEQ ID NO:2362: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2362: UUUUCCUUUU GUCAAUU 17 INFORMATION FOR SEQ ID NO:2363: 51 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2363: AAUUGACACU GAUGAGGCCG AAAGGCCGAA AAGGAAAA 38 INFORMATION FOR SEQ ID NO:2364: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2364: UUUCCUUUUG UCAAUUG 17 INFORMATION FOR SEQ ID NO:2365: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S"I* (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2365: CAAUUGACCU GAUGAGGCCG AAAGGCCGAA AAAGGAAA 38 INFORMATION FOR SEQ ID NO:2366: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2366: GCGAGGCGAG AAGGGGCUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2367: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2367: AGCCCCGGCC CGCCUCGC 18 INFORMATION FOR SEQ ID NO:2368: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2368: CAUGGCGAAG AAGGCCGGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 5i2 INFORMATION FOR SEQ ID NO:2369: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2369: CCGGCCCGCC UCGCCAUG 18 INFORMATION FOR SEQ ID NO:2370: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2370: AUUUGGGCAG AAGCCCAUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2371: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear o (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2371: AUGGGCUGCU GCCCAAAU 18 INFORMATION FOR SEQ ID NO:2372: SEQUENCE

CHARACTERISTICS:

LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2372: CAGAUUUGAG AAGCAGCCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2373: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2373: GGCUGCUGCC CAAAUCUG 18 INFORMATION FOR SEQ ID NO:2374: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2374: !5I3 UUCCAGUCAG AAGUUCCGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2375: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2375: CGGAACAGAC GACUGGAA 18 INFORMATION FOR SEQ ID NO:2376: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2376: UCCGGUUGAG AAGAUAAUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2377: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2377: AUUAUCUGCC CAACCGGA 18 INFORMATION FOR SEQ ID NO:2378: SEQUENCE CHARACTERISTICS: •oo* LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2378: CACUGUACAG AAGUCCGGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2379: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2379: CCGGACAGAU GUACAGUG 18 INFORMATION FOR SEQ ID NO:2380: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2380: CUCUGCCCAG AAGUUCCCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2381: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2381: GGGAACAGAU GGGCAGAG 18 INFORMATION FOR SEQ ID NO:2382: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2382: GUCCGGGCAG AAGCUUUGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2383: SEQUENCE

CHARACTERISTICS:

LENGTH: 18 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2383: CAAAGCUGCU GCCCGGAC 18 INFORMATION FOR SEQ ID NO:2384: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2384: UCCGUCCGAG AAGCAGCUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2385: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2385: AGCUGCUGCC CGGACGGA 18 INFORMATION FOR SEQ ID NO:2386: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single 515 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2386: AUCAGUCCAG AAGGGCAGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2387: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2387: CUGCCCGGAC GGACUGAU 18 INFORMATION FOR SEQ ID NO:2388: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2388: CAUUAUCAAG AAGUCCGGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2389: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2389: CCGGACGGAC UGAUAAUG 18 INFORMATION FOR SEQ ID NO:2390: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2390: CCACUGGCAG AAGGCUGGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2391: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2391: CCAGCCAGAC GCCAGUGG 18 INFORMATION FOR SEQ ID NO:2392: SEQUENCE CHARACTERISTICS: 516 LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2392: UUGGAGAGAG AAGAGAUGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2393: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2393: CAUCUCAGCU CUCUCCAA 18 INFORMATION FOR SEQ ID NO:2394: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single :i TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2394: UGACGGAGAG AAGGCCACAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2395: ,o SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2395: GUGGCCAGUC CUCCGUCA 18 INFORMATION FOR SEQ ID NO:2396: SEQUENCE

CHARACTERISTICS:

LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2396: UGCAAUGCAG AAGGAUAGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2397: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2397: CUAUCCUGUC GCAUUGCA in 5-7 INFORMATION FOR SEQ ID NO:2398: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2398: CCGCAGCCAG AAGAGGGAAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2399: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2399: UCCCUCAGCC GGCUGCGG 18 INFORMATION FOR SEQ ID NO:2400: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2400: GCUGCCGCAG AAGGCUGAAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2401: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2401: UCAGCCGGCU GCGGCAGC 18 INFORMATION FOR SEQ ID NO:2402: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2402: CUGUUGACAG AAGGAGCAAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2403: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2403: UGCUCCUGAU GUCAACAG in INFORMATION FOR SEQ ID NO:2404: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2404: GAGGUCUGAG AAGGUCCAAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2405: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2405: UGGACCAGAC CAGACCUC 18 INFORMATION FOR SEQ ID NO:2406: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2406: CCCAUGAGAG AAGGUCUGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2407: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2407: CAGACCAGAC CUCAUGGG 18 INFORMATION FOR SEQ ID NO:2408: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2408: AAACAGGAAG AAGGUGCAAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2409: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2409: 5(9 UGCACCUGUU UCCUGUUU 18 INFORMATION FOR SEQ ID NO:2410: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2410: UUCUCCCAAG AAGGAAACAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2411: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2411: GUUUCCUGUU UGGGAGAA 18 INFORMATION FOR SEQ ID NO:2412: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2412: GAUCUGCAAG AAGAGAUGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2413: SEQUENCE CHARACTERISTICS: *00 LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2413: CAUCUCUGCC UGCAGAUC 18 INFORMATION FOR SEQ ID NO:2414: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2414: GAGCCGGGAG AAGCAGGCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2415: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 520 O (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2415: GCCUGCAGAU CCCGGCUC 18 INFORMATION FOR SEQ ID NO:2416: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2416: AGGUAGGGAG AAGGGAUCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2417: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2417: GAUCCCGGCU CCCUACCU 18 "9 INFORMATION FOR SEQ ID NO:2418: 9.° SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2418: AAUCUAUAAG AAGGAGUGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 99o INFORMATION FOR SEQ ID NO:2419: SEQUENCE

CHARACTERISTICS:

LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2419: CACUCCAGUU UAUAGAUU 18 INFORMATION FOR SEQ ID NO:2420: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2420: UUUUCACAAG AAGGUCUCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2421: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single 521 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2421: GAGACCAGAC UGUGAAAA 18 INFORMATION FOR SEQ ID NO:2422: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2422: AUUUCUUGAG AAGCAAGGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2423: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2423: CCUUGCAGCU CAAGAAAU 18 INFORMATION FOR SEQ ID NO:2424: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2424: CUUCAGGGAG AAGUAUUUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 o* INFORMATION FOR SEQ ID NO:2425: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2425: AAAUACGGUC CCCUGAAG 18 INFORMATION FOR SEQ ID NO:2426: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2426: GGGAGGGGAG AAGAGGUAAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2427: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs 522 W TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2427: UACCUCAGAC CCCCUCCC 18 INFORMATION FOR SEQ ID NO:2428: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2428: CCAGAUUCAG AAGAUUCCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2429: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2429: GGAAUCGGAU GAAUCUGG 18 INFORMATION FOR SEQ ID NO:2430: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2430: GUGGUUUGAG AAGAAGAAAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2431: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2431: UUCUUCUGCU CAAACCAC 18 INFORMATION FOR SEQ ID NO:2432: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2432: GGUGCUCAAG AAGUUCUCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2433: 523 9 SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2433: GAGAACAGCC UGAGCACC 18 INFORMATION FOR SEQ ID NO:2434: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2434: CCUGCGAGAG AAGUUGGGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2435: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2435: SCCCAACUGUU CUCGCAGG 18 INFORMATION FOR SEQ ID NO:2436: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2436: UUUGGGGCAG AAGCCACAAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2437: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2437: UGUGGCAGAU GCCCCAAA 18 INFORMATION FOR SEQ ID NO:2438: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2438: GUCAUUAAAG AAGAGCUUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 524 INFORMATION FOR SEQ ID NO:2439: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2439: AAGCUCUGUU UUAAUGAC 18 INFORMATION FOR SEQ ID NO:2440: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2440: AGGCCGUCAG AAGGUCCUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2441: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2441: AGGACCAGAU GACGGCCU 18 INFORMATION FOR SEQ ID NO:2442: *0 SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear "o (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2442: SGGACCGGAAG AAGUCAUCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2443: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2443: GAUGACGGCC UCCGGUCC 18 INFORMATION FOR SEQ ID NO:2444: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2444: p CCGAGCCGAG AAGGAGGCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2445: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2445: GCCUCCGGUC CGGCUCGG 18 INFORMATION FOR SEQ ID NO:2446: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2446: UAUUUCCGAG AAGGACCGAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2447: S* SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2447: CGGUCCGGCU CGGAAAUA 18 INFORMATION FOR SEQ ID NO:2448: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2448: AGAGUUCGAG AAGAGAACAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2449: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2449: GUUCUCAGCU CGAACUCU 18 INFORMATION FOR SEQ ID NO:2450: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear 52GS w (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2450: ACAACAAAAG AAGGCUCUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2451: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2451: AGAGCCUGAU UUUGUUGU 18 INFORMATION FOR SEQ ID NO:2452: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2452: CUGCUCUCAG AAGUUGUAAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2453: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2453: UACAACAGUU GAGAGCAG 18 INFORMATION FOR SEQ ID NO:2454: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2454: UUAGGUAAAG AAGUUAUUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2455: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2455: AAUAACAGUC UUACCUAA 18 INFORMATION FOR SEQ ID NO:2456: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid 527 STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2456: UUUAAAAAAG AAGAUUAUAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2457: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2457: AUAAUCAGAU UUUUUAAA 18 INFORMATION FOR SEQ ID NO:2458: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S*(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2458: 0o 9 AAAUACUGAG AAGUUGUAAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2459: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2459: UACAACAGAU CAGUAUUU 18 INFORMATION FOR SEQ ID NO:2460: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2460: UUCAAGCAAG AAGACAACAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2461: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2461: GUUGUCAGCU UGCUUGAA 18 INFORMATION FOR SEQ ID NO:2462: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2462: AGUGCAUAAG AAGUUAUCAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 INFORMATION FOR SEQ ID NO:2463: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2463: GAUAACGGAC UAUGCACU 18 INFORMATION FOR SEQ ID NO:2464: SEQUENCE CHARACTERISTICS: LENGTH: 54 base pairs e' TYPE: nucleic acid S* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2464: AUAAAAAAAG AAGGAAUAAC CAGAGAAACA CACGUUGUGG UACAUUACCU GGUA 54 p INFORMATION FOR SEQ ID NO:2465: SEQUENCE CHARACTERISTICS: 6" 0 LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2465: SUAUUCCAGAC UUUUUUAU 18 6 INFORMATION FOR SEQ ID NO:2466: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:2466: CUCGGGCUUA GAUACGC 17 INFORMATION FOR SEQ ID NO:2467: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2467: GCGUAUCUCU GAUGAGGCCG AAAGGCCGAA AGCCCGAG 38 INFORMATION FOR SEQ ID NO:2468: 52 9 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2468: UCGGGCUUAG AUACGCC 17 INFORMATION FOR SEQ ID NO:2469: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2469: GGCGUAUCCU GAUGAGGCCG AAAGGCCGAA AAGCCCGA 38 INFORMATION FOR SEQ ID NO:2470: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2470: GCUUAGAUAC GCCUACU 17 INFORMATION FOR SEQ ID NO:2471: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2471: AGUAGGCGCU GAUGAGGCCG AAAGGCCGAA AUCUAAGC 38 INFORMATION FOR SEQ ID NO:2472: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2472: AUACGCCUAC UUUACCC 17 INFORMATION FOR SEQ ID NO:2473: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2473: GGGUAAAGCU GAUGAGGCCG AAAGGCCGAA AGGCGUAU In S(2) INFORMATION FOR SEQ ID NO:2474: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2474: CGCCUACUUU ACCCUCC 17 INFORMATION FOR SEQ ID NO:2475: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2475: GGAGGGUACU GAUGAGGCCG AAAGGCCGAA AGUAGGCG 38 INFORMATION FOR SEQ ID NO:2476: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2476: GCCUACUUUA CCCUCCA 17 INFORMATION FOR SEQ ID NO:2477: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2477: UGGAGGGUCU GAUGAGGCCG AAAGGCCGAA AAGUAGGC 38 INFORMATION FOR SEQ ID NO:2478: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2478: CCUACUUUAC CCUCCAC 17 INFORMATION FOR SEQ ID NO:2479: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2479: 53 i GUGGAGGGCU GAUGAGGCCG AAAGGCCGAA AAAGUAGG 38 INFORMATION FOR SEQ ID NO:2480: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2480: UUUACCCUCC ACGCCUC 17 INFORMATION FOR SEQ ID NO:2481: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2481: GAGGCGUGCU GAUGAGGCCG AAAGGCCGAA AGGGUAAA 38 INFORMATION FOR SEQ ID NO:2482: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S(B) TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2482: CCACGCCUCU CAUUGGU 17 INFORMATION FOR SEQ ID NO:2483: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2483: ACCAAUGACU GAUGAGGCCG AAAGGCCGAA AGGCGUGG 38 INFORMATION FOR SEQ ID NO:2484: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2484: ACGCCUCUCA UUGGUCA 17 INFORMATION FOR SEQ ID NO:2485: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S32 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2485: UGACCAAUCU GAUGAGGCCG AAAGGCCGAA AGAGGCGU 38 INFORMATION FOR SEQ ID NO:2486: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2486: CCUCUCAUUG GUCACAA 17 INFORMATION FOR SEQ ID NO:2487: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2487: UUGUGACCCU GAUGAGGCCG AAAGGCCGAA AUGAGAGG 38 INFORMATION FOR SEQ ID NO:2488: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2488: UCAUUGGUCA CAAACUG 17 INFORMATION FOR SEQ ID NO:2489: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2489: CAGUUUGUCU GAUGAGGCCG AAAGGCCGAA ACCAAUGA 38 INFORMATION FOR SEQ ID NO:2490: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2490: CACCGUGUCA CCGAGAC 17 INFORMATION FOR SEQ ID NO:2491: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 533 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2491: GUCUCGGUCU GAUGAGGCCG AAAGGCCGAA ACACGGUG 38 INFORMATION FOR SEQ ID NO:2492: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2492: UGAAAACUNA AAAGGAA 17 INFORMATION FOR SEQ ID NO:2493: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2493: UUCCUUUUCU GAUGAGGCCG AAAGGCCGAA AGUUUUCA 38 INFORMATION FOR SEQ ID NO:2494: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2494: GGAAAACUCN AUCUUUA 17 INFORMATION FOR SEQ ID NO:2495: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2495: UAAAGAUNCU GAUGAGGCCG AAAGGCCGAA AGUUUUCC 38 INFORMATION FOR SEQ ID NO:2496: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2496: AACUCNAUCU UUAGAAC 17 INFORMATION FOR SEQ ID NO:2497: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2497: GUUCUAAACU GAUGAGGCCG AAAGGCCGAA AUNGAGUU 38 INFORMATION FOR SEQ ID NO:2498: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2498: CUCNAUCUUU AGAACUC 17 INFORMATION FOR SEQ ID NO:2499: SEQUENCE CHARACTERISTICS: *o LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2499: GAGUUCUACU GAUGAGGCCG AAAGGCCGAA AGAUNGAG 38 INFORMATION FOR SEQ ID NO:2500: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S* TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2500: UCNAUCUUA GAACUCC 17 INFORMATION FOR SEQ ID NO:2501: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2501: GGAGUUCUCU GAUGAGGCCG AAAGGCCGAA AAGAUNGA 38 INFORMATION FOR SEQ ID NO:2502: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2502: CNAUCUUUAG AACUCCA 535> INFORMATION FOR SEQ ID NO:2503: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2503: UGGAGUUCCU GAUGAGGCCG AAAGGCCGAA AAAGAUNG 38 INFORMATION FOR SEQ ID NO:2504: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2504: UUAGAACUCC AGCUAUC 17 INFORMATION FOR SEQ ID NO:2505: S' SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2505: GAUAGCUGCU GAUGAGGCCG AAAGGCCGAA AGUUCUAA 38 INFORMATION FOR SEQ ID NO:2506: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2506: CUCCAGCUAU CAAAAGG 17 *sees: INFORMATION FOR SEQ ID NO:2507: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2507: CCUUUUGACU GAUGAGGCCG AAAGGCCGAA AGCUGGAG 38 INFORMATION FOR SEQ ID NO:2508: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2508: CCAGCUAUCA AAAGGUN 17 INFORMATION FOR SEQ ID NO:2509: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2509: NACCUUUUCU GAUGAGGCCG AAAGGCCGAA AUAGCUGG 38 INFORMATION FOR SEQ ID NO:2510: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2510: CAAAAGGUNA AUCCUCG 17 INFORMATION FOR SEQ ID NO:2511: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2511: CGAGGAUUCU GAUGAGGCCG AAAGGCCGAA ACCUUUUG 38 INFORMATION FOR SEQ ID NO:2512: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2512: AGGUNAAUCC UCGAAAG 17 INFORMATION FOR SEQ ID NO:2513: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2513: CUUUCGAGCU GAUGAGGCCG AAAGGCCGAA AUUNACCU 38 INFORMATION FOR SEQ ID NO:2514: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2514: :37 UNAAUCCUCG AAAGCUC 17 INFORMATION FOR SEQ ID NO:2515: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2515: GAGCUUUCCU GAUGAGGCCG AAAGGCCGAA AGGAUUNA 38 INFORMATION FOR SEQ ID NO:2516: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2516: CGAAAGCUCU CCCAGAA 17 INFORMATION FOR SEQ ID NO:2517: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2517: UUCUGGGACU GAUGAGGCCG AAAGGCCGAA AGCUUUCG 38 INFORMATION FOR SEQ ID NO:2518: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2518: AAAGCUCUCC CAGAACU 17 INFORMATION FOR SEQ ID NO:2519: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2519: AGUUCUGGCU GAUGAGGCCG AAAGGCCGAA AGAGCUUU 38 INFORMATION FOR SEQ ID NO:2520: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2520: CCAGAACUCC CACACCA 17 INFORMATION FOR SEQ ID NO:2521: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2521: UGGUGUGGCU GAUGAGGCCG AAAGGCCGAA AGUUCUGG 38 INFORMATION FOR SEQ ID NO:2522: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2522: CACACCAUUC

AAACAUG

17 INFORMATION FOR SEQ ID NO:2523: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2523: CAUGUUUGCU GAUGAGGCCG AAAGGCCGAA AUGGUGUG 38 S. INFORMATION FOR SEQ ID NO:2524: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2524: ACACCAUUCA AACAUGC 17 INFORMATION FOR SEQ ID NO:2525: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2525: GCAUGUUUCU GAUGAGGCCG AAAGGCCGAA AAUGGUGU 38 INFORMATION FOR SEQ ID NO:2526: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2526: UGGCAGCUCA AGAAAUU 17 INFORMATION FOR SEQ ID NO:2527: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2527: AAUUUCUUCU GAUGAGGCCG AAAGGCCGAA AGCUGCCA 38 INFORMATION FOR SEQ ID NO:2528: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2528: CAAGAAAUUA AAUACGG INFORMATION FOR SEQ ID NO:2529: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID N0:2529: o* CCGUAUUUCU GAUGAGGCCG AAAGGCCGAA AUUUCUUG 38 INFORMATION FOR SEQ ID NO:2530: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid i STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2530: AAGAAAUUAA AUACGGU 17 INFORMATION FOR SEQ ID NO:2531: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2531: ACCGUAUUCU GAUGAGGCCG AAAGGCCGAA AAUUUCUU 38 INFORMATION FOR SEQ ID NO:2532: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs 540 TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2532: AAUUAAAUAC GGUCCCC 17 INFORMATION FOR SEQ ID NO:2533: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2533: GGGGACCGCU GAUGAGGCCG AAAGGCCGAA AUUUAAUU 38 INFORMATION FOR SEQ ID NO:2534: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2534: AAUACGGUCC CCUGAAG 17 INFORMATION FOR SEQ ID NO:2535: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2535: CUUCAGGGCU GAUGAGGCCG AAAGGCCGAA ACCGUAUU 38 INFORMATION FOR SEQ ID NO:2536: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2536: AAGAUGCUAC CUNAGAC 17 INFORMATION FOR SEQ ID NO:2537: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2537: GUCUNAGGCU GAUGAGGCCG AAAGGCCGAA AGCAUCUU 38 INFORMATION FOR SEQ ID NO:2538: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2538: UGCUACCUNA GACCCCC 17 INFORMATION FOR SEQ ID NO:2539: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2539: GGGGGUCUCU GAUGAGGCCG AAAGGCCGAA AGGUAGCA 38 INFORMATION FOR SEQ ID NO:2540: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2540: GACCCCCUNU NAUGUAG 17 INFORMATION FOR SEQ ID NO:2541: i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2541: CUACAUNACU GAUGAGGCCG AAAGGCCGAA AGGGGGUC 38 INFORMATION FOR SEQ ID NO:2542: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2542: CCCCCUNUNA UGUAGUN 17 INFORMATION FOR SEQ ID NO:2543: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2543: NACUACAUCU GAUGAGGCCG AAAGGCCGAA ANAGGGGG 38 542 INFORMATION FOR SEQ ID NO:2544: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2544: UNUNAUGUAG UNNNANA 17 INFORMATION FOR SEQ ID NO:2545: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2545: UNUNNNACCU GAUGAGGCCG AAAGGCCGAA ACAUNANA 38 INFORMATION FOR SEQ ID NO:2546: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S* STRANDEDNESS: single S* TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2546: NAUGUAGUNN NANACCU 17 INFORMATION FOR SEQ ID NO:2547: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2547: *9 AGGUNUNNCU GAUGAGGCCG AAAGGCCGAA ACUACAUN 38 INFORMATION FOR SEQ ID NO:2548: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2548: NNANACCUNC ANGAUGU 17 INFORMATION FOR SEQ ID NO:2549: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2549: ACAUCNUGCU GAUGAGGCCG AAAGGCCGAA AGGUNUNN 38 INFORMATION FOR SEQ ID NO:2550: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (ix) FEATURE: OTHER INFORMATION: The letter stands for any base.

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2550: CCUNAUCUCA UCAAGGG 17 INFORMATION FOR SEQ ID NO:2551: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (ix) FEATURE: OTHER INFORMATION: The letter stands S* for any base.

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2551: CCCUUGAUCU GAUGAGGCCG AAAGGCCGAA AGAUNAGG 38 INFORMATION FOR SEQ ID NO:2552: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (ix) FEATURE: OTHER INFORMATION: The letter stands for any base.

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2552: NAUCUCAUCA AGGGUCC 17 INFORMATION FOR SEQ ID NO:2553: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (ix) FEATURE: OTHER INFORMATION: The letter stands for any base.

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2553: GGACCCUUCU GAUGAGGCCG AAAGGCCGAA AUGAGAUN o W INFORMATION FOR SEQ ID NO:2554: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2554: UCAAGGGUCC UUGGACC 17 INFORMATION FOR SEQ ID NO:2555: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2555: GGUCCAAGCU GAUGAGGCCG AAAGGCCGAA ACCCUUGA 38 INFORMATION FOR SEQ ID NO:2556: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2556: AGGGUCCUUG

GACCAAA

17 INFORMATION FOR SEQ ID NO:2557: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2557: UUUGGUCCCU GAUGAGGCCG AAAGGCCGAA AGGACCCU 38 INFORMATION FOR SEQ ID NO:2558: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2558: AAGAAGAUCA GAGAGUG 17 INFORMATION FOR SEQ ID NO:2559: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2559: 545 CACUCUCUCU GAUGAGGCCG AAAGGCCGAA AUCUUCUU 38 INFORMATION FOR SEQ ID NO:2560: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2560: AGAGUGAUAG AGCUUGU 17 INFORMATION FOR SEQ ID NO:2561: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2561: ACAAGCUCCU GAUGAGGCCG AAAGGCCGAA AUCACUCU 38 INFORMATION FOR SEQ ID NO:2562: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2562: AUAGAGCUUG UACAGAA 17 INFORMATION FOR SEQ ID NO:2563: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:2563: UUCUGUACCU GAUGAGGCCG AAAGGCCGAA AGCUCUAU 38 INFORMATION FOR SEQ ID NO:2564: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2564: GAGCUUGUAC AGAAAUA 17 INFORMATION FOR SEQ ID NO:2565: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2565: UAUUUCUGCU GAUGAGGCCG AAAGGCCGAA ACAAGCUC 38 INFORMATION FOR SEQ ID NO:2566: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2566: ACAGAAAUAC GGUCCGA 17 INFORMATION FOR SEQ ID NO:2567: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2567: UCGGACCGCU GAUGAGGCCG AAAGGCCGAA AUUUCUGU 38 INFORMATION FOR SEQ ID NO:2568: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2568: AAUACGGUCC GAAACGU 17 INFORMATION FOR SEQ ID NO:2569: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2569: ACGUUUCGCU GAUGAGGCCG AAAGGCCGAA ACCGUAUU 38 INFORMATION FOR SEQ ID NO:2570: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2570: CGAAACGUUG GUCUGUU 17 INFORMATION FOR SEQ ID NO:2571: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single F TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2571: AACAGACCCU GAUGAGGCCG AAAGGCCGAA ACGUUUCG 38 INFORMATION FOR SEQ ID NO:2572: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2572: ACGUUGGUCU GUUAUUG 17 INFORMATION FOR SEQ ID NO:2573: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2573: CAAUAACACU GAUGAGGCCG AAAGGCCGAA ACCAACGU 38 INFORMATION FOR SEQ ID NO:2574: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid S* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2574: e* UGGUCUGUUA UUGCCAA 17 INFORMATION FOR SEQ ID NO:2575: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2575: UUGGCAAUCU GAUGAGGCCG AAAGGCCGAA ACAGACCA 38 INFORMATION FOR SEQ ID NO:2576: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2576: GGUCUGUUAU UGCCAAG 17 INFORMATION FOR SEQ ID NO:2577: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2577: CUUGGCAACU GAUGAGGCCG AAAGGCCGAA AACAGACC 38 INFORMATION FOR SEQ ID NO:2578: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2578: UCUGUUAUUG CCAAGCA 17 INFORMATION FOR SEQ ID NO:2579: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S'(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2579: UGCUUGGCCU GAUGAGGCCG AAAGGCCGAA AUAACAGA 38 INFORMATION FOR SEQ ID NO:2580: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2580: CAAGCACUUA AAGGGGA 17 INFORMATION FOR SEQ ID NO:2581: SEQUENCE

CHARACTERISTICS:

LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2581: UCCCCUUUCU GAUGAGGCCG AAAGGCCGAA AGUGCUUG 38 INFORMATION FOR SEQ ID NO:2582: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2582: AAGCACUUAA

AGGGGAG

17 INFORMATION FOR SEQ ID NO:2583: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2583: CUCCCCUUCU GAUGAGGCCG AAAGGCCGAA AAGUGCUU 38 INFORMATION FOR SEQ ID NO:2584: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2584: GGGAGAAUUG GAAAACA 17 INFORMATION FOR SEQ ID NO:2585: i) SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S: (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2585: UGUUUUCCCU GAUGAGGCCG AAAGGCCGAA AUUCUCCC 38 INFORMATION FOR SEQ ID NO:2586: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2586: S AACAAUGUAG GGAGAGG 17 INFORMATION FOR SEQ ID NO:2587: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2587: CCUCUCCCCU GAUGAGGCCG AAAGGCCGAA ACAUUGUU 38 INFORMATION FOR SEQ ID NO:2588: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2588: GGUGGCAUAA CCACUUG 17 INFORMATION FOR SEQ ID NO:2589: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2589: CAAGUGGUCU GAUGAGGCCG AAAGGCCGAA AUGCCACC 38 INFORMATION FOR SEQ ID NO:2590: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2590: UAACCACUUG AAUCCAG 17 INFORMATION FOR SEQ ID NO:2591: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S* STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2591: CUGGAUUCCU GAUGAGGCCG AAAGGCCGAA AGUGGUUA 38 INFORMATION FOR SEQ ID NO:2592: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2592: ACUUGAAUCC AGAAGUU 17 17 INFORMATION FOR SEQ ID NO:2593: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2593: AACUUCUGCU GAUGAGGCCG AAAGGCCGAA AUUCAAGU 38 INFORMATION FOR SEQ ID NO:2594: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2594: CCAGAAGUUA AGAAAAC 17 INFORMATION FOR SEQ ID NO:2595: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2595: GUUUUCUUCU GAUGAGGCCG AAAGGCCGAA ACUUCUGG 38 INFORMATION FOR SEQ ID NO:2596: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2596: CAGAAGUUAA GAAAACC 17 INFORMATION FOR SEQ ID NO:2597: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2597: GGUUUUCUCU GAUGAGGCCG AAAGGCCGAA AACUUCUG 38 INFORMATION FOR SEQ ID NO:2598: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2598: GAAAACCUCC UGGACAG 17 INFORMATION FOR SEQ ID NO:2599: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2599: CUGUCCAGCU GAUGAGGCCG AAAGGCCGAA AGGUUUUC 38 INFORMATION FOR SEQ ID NO:2600: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear w (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2600: GACAGAAUUA UUUACCA 17 INFORMATION FOR SEQ ID NO:2601: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2601: UGGUAAAUCU GAUGAGGCCG AAAGGCCGAA AUUCUGUC 38 INFORMATION FOR SEQ ID NO:2602: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2602: ACAGAAUUAU

UUACCAG

17 INFORMATION FOR SEQ ID NO:2603: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2603: CUGGUAAACU GAUGAGGCCG AAAGGCCGAA AAUUCUGU 38 INFORMATION FOR SEQ ID NO:2604: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2604: AGAAUUAUUU ACCAGGC 17 INFORMATION FOR SEQ ID NO:2605: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2605: GCCUGGUACU GAUGAGGCCG AAAGGCCGAA AUAAUUCU 38 INFORMATION FOR SEQ ID NO:2606: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid 553 STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2606: GAAUUAUUUA CCAGGCA 17 INFORMATION FOR SEQ ID NO:2607: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2607: UGCCUGGUCU GAUGAGGCCG AAAGGCCGAA AAUAAUUC 38 INFORMATION FOR SEQ ID NO:2608: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2608: SAAUUAUUUAC

CAGGCAC

1 7 INFORMATION FOR SEQ ID NO:2609: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2609: GUGCCUGGCU GAUGAGGCCG AAAGGCCGAA AAAUAAUU 38 INFORMATION FOR SEQ ID NO:2610: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2610: GCGGAAAUCG

CAAAGCU

17 INFORMATION FOR SEQ ID NO:2611: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2611: AGCUUUGCCU GAUGAGGCCG AAAGGCCGAA AUUUCCGC 38 INFORMATION FOR SEQ ID NO:2612: SEQUENCE CHARACTERISTICS: S

C

C

C

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2612: GCAAAGCUAC UGCCUGG INFORMATION FOR SEQ ID NO:2613: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2613: CCAGGCAGCU GAUGAGGCCG AAAGGCCGAA AGCUUUGC INFORMATION FOR SEQ ID NO:2614: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2614: GAUUCUUUCU UAAACAC INFORMATION FOR SEQ ID NO:2615: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2615: GUGUUUAACU GAUGAGGCCG AAAGGCCGAA AAAGAAUC INFORMATION FOR SEQ ID NO:2616: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2616: UUCUUUCUUA AACACUU INFORMATION FOR SEQ ID NO:2617: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2617: AAGUGUUUCU GAUGAGGCCG AAAGGCCGAA AGAAAGAA INFORMATION FOR SEQ ID NO:2618: 17 38 17 38 17 38 555 SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2618: UCUUUCUUAA ACACUUC 17 INFORMATION FOR SEQ ID NO:2619: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2619: GAAGUGUUCU GAUGAGGCCG AAAGGCCGAA AAGAAAGA 38 INFORMATION FOR SEQ ID NO:2620: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2620: UAAACACUUC CAAUAAC 17 INFORMATION FOR SEQ ID NO:2621: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2621: GUUAUUGGCU GAUGAGGCCG AAAGGCCGAA AGUGUUUA 38 INFORMATION FOR SEQ ID N0:2622: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2622: AAACACUUCC AAUAACC 17 INFORMATION FOR SEQ ID NO:2623: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2623: GGUUAUUGCU GAUGAGGCCG AAAGGCCGAA AAGUGUUU In INFORMATION FOR SEQ ID NO:2624: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2624: CUUCCAAUAA CCAUGAA 17 INFORMATION FOR SEQ ID NO:2625: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2625: UUCAUGGUCU GAUGAGGCCG AAAGGCCGAA AUUGGAAG 38 INFORMATION FOR SEQ ID NO:2626: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs S* TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2626: UGAAAACUUA GACUUGG 17 INFORMATION FOR SEQ ID NO:2627: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S" STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2627: CCAAGUCUCU GAUGAGGCCG AAAGGCCGAA AGUUUUCA 38 INFORMATION FOR SEQ ID NO:2628: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2628: GAAAACUUAG ACUUGGA 17 INFORMATION FOR SEQ ID NO:2629: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2629: 57 UCCAAGUCCU GAUGAGGCCG AAAGGCCGAA AAGUUUUC 38 INFORMATION FOR SEQ ID NO:2630: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2630: CUUAGACUUG GAAAUGC 17 INFORMATION FOR SEQ ID NO:2631: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2631: GCAUUUCCCU GAUGAGGCCG AAAGGCCGAA AGUCUAAG 38 INFORMATION FOR SEQ ID NO:2632: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear SEQUENCE DESCRIPTION: SEQ ID NO:2632: AAAUGCCUUC UUUAACG 17 INFORMATION FOR SEQ ID NO:2633: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2633: CGUUAAAGCU GAUGAGGCCG AAAGGCCGAA AGGCAUUU 38 INFORMATION FOR SEQ ID NO:2634: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2634: AAUGCCUUCU UUAACGU 17 INFORMATION FOR SEQ ID NO:2635: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2635: ACGUUAAACU GAUGAGGCCG AAAGGCCGAA AAGGCAUU 38 INFORMATION FOR SEQ ID NO:2636: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2636: UGCCUUCUUU AACGUCC 17 INFORMATION FOR SEQ ID NO:2637: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2637: GGACGUUACU GAUGAGGCCG AAAGGCCGAA AGAAGGCA 38 INFORMATION FOR SEQ ID NO:2638: t SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2638: 9.* 9 GCCUUCUUUA ACGUCCA 17 INFORMATION FOR SEQ ID NO:2639: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2639: UGGACGUUCU GAUGAGGCCG AAAGGCCGAA AAGAAGGC 38 INFORMATION FOR SEQ ID NO:2640: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2640: CCUUCUUUAA CGUCCAC 17 INFORMATION FOR SEQ ID NO:2641: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2641: GUGGACGUCU GAUGAGGCCG AAAGGCCGAA AAAGAAGG 38 INFORMATION FOR SEQ ID N0:2642: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2642: UUUAACGUCC ACGCCUC 17 INFORMATION FOR SEQ ID NO:2643: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2643: GAGGCGUGCU GAUGAGGCCG AAAGGCCGAA ACGUUAAA 38 INFORMATION FOR SEQ ID NO:2644: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2644: CCACGCCUCU CAGUGGU 17 INFORMATION FOR SEQ ID NO:2645: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2645: ACCACUGACU GAUGAGGCCG AAAGGCCGAA AGGCGUGG 38 INFORMATION FOR SEQ ID NO:2646: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2646: ACGCCUCUCA GUGGUCA 17 INFORMATION FOR SEQ ID NO:2647: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid 500O STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2647: UGACCACUCU GAUGAGGCCG AAAGGCCGAA AGAGGCGU 38 INFORMATION FOR SEQ ID NO:2648: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2648: UCAGUGGUCA CAAAUUG 17 INFORMATION FOR SEQ ID NO:2649: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single o* TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2649: *CAAUUUGUCU GAUGAGGCCG AAAGGCCGAA ACCACUGA 38 INFORMATION FOR SEQ ID NO:2650: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2650: UCACAAAUUG ACUGUUA 17 INFORMATION FOR SEQ ID NO:2651: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2651: UAACAGUCCU GAUGAGGCCG AAAGGCCGAA AUUUGUGA 38 INFORMATION FOR SEQ ID NO:2652: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2652: UUGACUGUUA CAACACC 17 INFORMATION FOR SEQ ID NO:2653: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2653: GGUGUUGUCU GAUGAGGCCG AAAGGCCGAA ACAGUCAA 38 INFORMATION FOR SEQ ID NO:2654: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2654: UGACUGUUAC AACACCA 17 INFORMATION FOR SEQ ID NO:2655: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2655: *e UGGUGUUGCU GAUGAGGCCG AAAGGCCGAA AACAGUCA 38 INFORMATION FOR SEQ ID NO:2656: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2656: AACACCAUUU CAUAGAG 17 INFORMATION FOR SEQ ID NO:2657: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2657: CUCUAUGACU GAUGAGGCCG AAAGGCCGAA AUGGUGUU 38 INFORMATION FOR SEQ ID NO:2658: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2658: ACACCAUUUC AUAGAGA 17 INFORMATION FOR SEQ ID NO:2659: 502 SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2659: UCUCUAUGCU GAUGAGGCCG AAAGGCCGAA AAUGGUGU 38 INFORMATION FOR SEQ ID NO:2660: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2660: CACCAUUUCA UAGAGAC 17 INFORMATION FOR SEQ ID NO:2661: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2661: GUCUCUAUCU GAUGAGGCCG AAAGGCCGAA AAAUGGUG 38 INFORMATION FOR SEQ ID NO:2662: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2662: CAUUUCAUAG AGACCAG 17 INFORMATION FOR SEQ ID NO:2663: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2663: CUGGUCUCCU GAUGAGGCCG AAAGGCCGAA AUGAAAUG 38 INFORMATION FOR SEQ ID NO:2664: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2664: AGGAAAAUAC AUAUUUU 17 S63 INFORMATION FOR SEQ ID NO:2665: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2665: AAAAUAUGCU GAUGAGGCCG AAAGGCCGAA AUUUUCCU 38 INFORMATION FOR SEQ ID NO:2666: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2666: AAAUACAUAU UUUUGAA 17 INFORMATION FOR SEQ ID NO:2667: i) SEQUENCE CHARACTERISTICS: S(A) LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2667: UUCAAAAACU GAUGAGGCCG AAAGGCCGAA AUGUAUUU 38 INFORMATION FOR SEQ ID NO:2668: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2668: AUACAUAUUU UUGAACU 17 INFORMATION FOR SEQ ID NO:2669: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2669: AGUUCAAACU GAUGAGGCCG AAAGGCCGAA AUAUGUAU 38 INFORMATION FOR SEQ ID NO:2670: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2670: UACAUAUUUU UGAACUC 17 INFORMATION FOR SEQ ID NO:2671: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2671: GAGUUCAACU GAUGAGGCCG AAAGGCCGAA AAUAUGUA 38 INFORMATION FOR SEQ ID NO:2672: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2672: ACAUAUUUUU GAACUCC 17 INFORMATION FOR SEQ ID NO:2673: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2673: GGAGUUCACU GAUGAGGCCG AAAGGCCGAA AAAUAUGU 38 INFORMATION FOR SEQ ID NO:2674: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2674: CAUAUUUUUG AACUCCG 17 INFORMATION FOR SEQ ID NO:2675: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2675: CGGAGUUCCU GAUGAGGCCG AAAGGCCGAA AAAAUAUG 38 INFORMATION FOR SEQ ID NO:2676: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2676: S UUUGAACUCC GGCUAUC 17 INFORMATION FOR SEQ ID NO:2677: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2677: GAUAGCCGCU GAUGAGGCCG AAAGGCCGAA AGUUCAAA 38 INFORMATION FOR SEQ ID NO:2678: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2678: CUCCGGCUAU CAAAAGG 17 INFORMATION FOR SEQ ID NO:2679: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2679: CCUUUUGACU GAUGAGGCCG AAAGGCCGAA AGCCGGAG 38 INFORMATION FOR SEQ ID NO:2680: SEQUENCE

CHARACTERISTICS:

LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2680: CCGGCUAUCA AAAGGUC 17 INFORMATION FOR SEQ ID NO:2681: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2681: GACCUUUUCU GAUGAGGCCG AAAGGCCGAA AUAGCCGG 38 INFORMATION FOR SEQ ID NO:2682: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2682: CAAAAGGUCA AUCCUGG 17 INFORMATION FOR SEQ ID NO:2683: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2683: CCAGGAUUCU GAUGAGGCCG AAAGGCCGAA ACCUUUUG 38 INFORMATION FOR SEQ ID NO:2684: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2684: AGGUCAAUCC UGGAAAG 17 INFORMATION FOR SEQ ID NO:2685: SI SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2685: CUUUCCAGCU GAUGAGGCCG AAAGGCCGAA AUUGACCU 38 INFORMATION FOR SEQ ID NO:2686: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2686: GGAAAGCUCU CCAAGAA 17 INFORMATION FOR SEQ ID NO:2687: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2687: UUCUUGGACU GAUGAGGCCG AAAGGCCGAA AGCUUUCC 38 INFORMATION FOR SEQ ID NO:2688: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid s6 7 STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2688: AAAGCUCUCC AAGAACU 17 INFORMATION FOR SEQ ID NO:2689: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2689: AGUUCUUGCU GAUGAGGCCG AAAGGCCGAA AGAGCUUU 38 INFORMATION FOR SEQ ID NO:2690: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2690: S* CAAGAACUCC UACACCG 17 INFORMATION FOR SEQ ID NO:2691: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2691: CGGUGUAGCU GAUGAGGCCG AAAGGCCGAA AGUUCUUG 38 INFORMATION FOR SEQ ID NO:2692: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2692: GAACUCCUAC ACCGUUC 17 INFORMATION FOR SEQ ID NO:2693: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2693: GAACGGUGCU GAUGAGGCCG AAAGGCCGAA AGGAGUUC 38 INFORMATION FOR SEQ ID NO:2694: SEQUENCE CHARACTERISTICS: w LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2694: UACACCGUUC AAACAUG 17 INFORMATION FOR SEQ ID NO:2695: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2695: CAUGUUUGCU GAUGAGGCCG AAAGGCCGAA ACGGUGUA 38 INFORMATION FOR SEQ ID NO:2696: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single S(D) TOPOLOGY: linear o (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2696: ACACCGUUCA AACAUGC 17 INFORMATION FOR SEQ ID NO:2697: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2697: GCAUGUUUCU GAUGAGGCCG AAAGGCCGAA AACGGUGU 38 INFORMATION FOR SEQ ID NO:2698: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2698: CAUGCACUCG CAGCUCA 17 INFORMATION FOR SEQ ID NO:2699: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2699: UGAGCUGCCU GAUGAGGCCG AAAGGCCGAA AGUGCAUG 38 INFORMATION FOR SEQ ID NO:2700: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2700: UCGCAGCUCA AGAAAUU 17 INFORMATION FOR SEQ ID NO:2701: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2701: AAUUUCUUCU GAUGAGGCCG AAAGGCCGAA AGCUGCGA 38 S' INFORMATION FOR SEQ ID NO:2702: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single o* o: TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2702: CAAGAAAUUA AAUAUGG 17 INFORMATION FOR SEQ ID NO:2703: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2703: 98 *9 S* CCAUAUUUCU GAUGAGGCCG AAAGGCCGAA AUUUCUUG 38 INFORMATION FOR SEQ ID NO:2704: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2704: AAGAAAUUAA AUAUGGU 17 INFORMATION FOR SEQ ID NO:2705: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2705: ACCAUAUUCU GAUGAGGCCG AAAGGCCGAA AAUUUCUU

RA

O INFORMATION FOR SEQ ID NO:2706: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2706: AAUUAAAUAU GGUCCCC 17 INFORMATION FOR SEQ ID NO:2707: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2707: GGGGACCACU GAUGAGGCCG AAAGGCCGAA AUUUAAUU 38 INFORMATION FOR SEQ ID NO:2708: SEQUENCE CHARACTERISTICS: S* LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2708: SAAUAUGGUCC CCUGAAG 17 INFORMATION FOR SEQ ID NO:2709: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2709: CUUCAGGGCU GAUGAGGCCG AAAGGCCGAA ACCAUAUU 38 INFORMATION FOR SEQ ID NO:2710: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2710: AAGAUGCUAC CUCAGAC 17 INFORMATION FOR SEQ ID NO:2711: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2711: 7 i GUCUGAGGCU GAUGAGGCCG AAAGGCCGAA AGCAUCUU 38 INFORMATION FOR SEQ ID NO:2712: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2712: UGCUACCUCA GACACCA 17 INFORMATION FOR SEQ ID NO:2713: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2713: UGGUGUCUCU GAUGAGGCCG AAAGGCCGAA AGGUAGCA 38 INFORMATION FOR SEQ ID NO:2714: SEQUENCE CHARACTERISTICS: S* LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2714: e GACACCAUCU CAUUUAG 17 INFORMATION FOR SEQ ID NO:2715: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid S(C) STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2715: CUAAAUGACU GAUGAGGCCG AAAGGCCGAA AUGGUGUC 38 INFORMATION FOR SEQ ID NO:2716: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2716: CACCAUCUCA UUUAGUA 17 INFORMATION FOR SEQ ID NO:2717: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear -72 S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2717: UACUAAAUCU GAUGAGGCCG AAAGGCCGAA AGAUGGUG 38 INFORMATION FOR SEQ ID NO:2718: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2718: CAUCUCAUUU AGUAGAA 17 INFORMATION FOR SEQ ID NO:2719: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2719: UUCUACUACU GAUGAGGCCG AAAGGCCGAA AUGAGAUG 38 INFORMATION FOR SEQ ID NO:2720: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2720: AUCUCAUUUA GUAGAAG 17 INFORMATION FOR SEQ ID NO:2721: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2721: CUUCUACUCU GAUGAGGCCG AAAGGCCGAA AAUGAGAU 38 INFORMATION FOR SEQ ID NO:2722: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2722: UCUCAUUUAG UAGAAGA 17 INFORMATION FOR SEQ ID NO:2723: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single 575 TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2723: UCUUCUACCU GAUGAGGCCG AAAGGCCGAA AAAUGAGA 38 INFORMATION FOR SEQ ID NO:2724: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2724: CAUUUAGUAG AAGACCU 17 INFORMATION FOR SEQ ID NO:2725: SEQUENCE CHARACTERISTICS: LENGTH: 38 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2725: o AGGUCUUCCU GAUGAGGCCG AAAGGCCGAA ACUAAAUG 38 38 INFORMATION FOR SEQ ID NO:2726: SEQUENCE CHARACTERISTICS: LENGTH: 11 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (ix) FEATURE: OTHER INFORMATION: The letter stands for any base. "H" represents nucleotide C, A, or U.

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2726: NNNNUHNNNN N 11 INFORMATION FOR SEQ ID NO:2727: SEQUENCE CHARACTERISTICS: LENGTH: 28 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (ix) FEATURE: OTHER INFORMATION: The letter stands for any base.

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2727: NNNNNCUGAN GAGNNNNNNC GAAANNNN 28 INFORMATION FOR SEQ ID NO:2728: SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (ix) FEATURE: OTHER INFORMATION: The letter stands for any base. The leter "Y" is U or C. The letter is A, U, or C.

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2728: NNNNNNNYNG HYNNN INFORMATION FOR SEQ ID NO:2729: SEQUENCE

CHARACTERISTICS:

LENGTH: 47 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (ix) FEATURE: OTHER INFORMATION: The letter stands for any base. "H" represents nucleotide C, A, or U.

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2729: NNNNGAAGNN NNNNNNNNNA AAHANNNNNN NACAUUACNN NNNNNNN 47 o INFORMATION FOR SEQ ID NO:2730: SEQUENCE CHARACTERISTICS: LENGTH: 85 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2730: UGGCCGGCAU GGUCCCAGCC UCCUCGCUGG CGCCGGCUGG GCAACAUUCC GAGGGGACCG UCCCCUCGGU AAUGGCGAAU GGGAC INFORMATION FOR SEQ ID NO:2731: SEQUENCE CHARACTERISTICS: LENGTH: 176 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2731: Ad 57,5 GGGAAAGCUtJ GCGAAGGGCG

UCGUCGCCCC

AUEJUCAGUAC UGAAAUGuc GUAGCAGUUG UGACGGUAUtJ GGCGUAAGUC AGUAUEJGCAG GAGCGGUAGU AAGCAGGGAA CUCACCUCCA ACUACUGUIA UGUGAUTJGGU

AGAGGCUAAG

CACAGCACAA GCCCGCJEGC GAGAAU 120 176 INFORMATION FOR SEQ ID NO:2732: Wi SEQUENCE CHARACTERISTICS: LENGTH: 15 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2732: GGAGAAUJGG AAAAC INFORMATION FOR SEQ ID NO:2733: SEQUENCE CHARACTERISTICS: LENGTH: 36 base pairs TYPE: nucleic acid STRANDEDNESS: single TOPOLOGY: linear (ix) FEATURE: (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2733: GtUTJTCCCUG AUGAGGCCGA AAGGCCGAAA AUCUC a 9* a.

a a a.

a. a. a.

a. a a a. a a. a a a

Claims (114)

1. 5-76 The claims defining the invention are as follows: 1. An enzymatic nucleic acid molecule which cleaves c-myb RNA, wherein the the binding arms of said nucleic acid contain sequences complementary to the sequences defined in Tables II, XII-XXIV. 2. An enzymatic nucleic acid molecule which cleaves RNA produced from a gene selected from one encoding c-fos, oct-1, SRF, PDGF receptor, bFGF receptor, angiotensin II, and endothelium-derived relaxing factor. 3. The enzymatic nucleic acid molecule of claims i or 2 wherein said nucleic acid molecule is in a hammerhead motif. 4. The enzymatic nucleic acid molecule of claim 1 or 2, wherein said nucleic acid molecule is in a hairpin, hepatitis delta virus, VS nucleic acid, group I intron, or RNAseP nucleic acid motif. The enzymatic nucleic acid molecule of claim 3 or 4, wherein said nucleic acid comprises between 12 and 100 bases complementary to said mRNA.
2. 6. The enzymatic nucleic acid molecule of claim wherein said nucleic acid comprises between 14 and 24 bases complementary to said mRNA.
3. 7. Enzymatic nucleic acid molecule consisting essentially of any sequence selected from the group of sequences listed in Tables III, XII-XXIV.
4. 8. A mammalian cell including an enzymatic nucleic acid molecule of any one of claims 1 or 2.
5. 9. The cell of claim 8, wherein said cell is a human cell. 5-77 An expression vector including nucleic acid encoding an enzymatic nucleic acid molecule or multiple enzymatic molecules of claims 1 or 2 in a manner which allows expression of that enzymatic RNA molecule(s) within a mammalian cell. 0 11. A mammalian cell including an expression vector of claim
6. 12. The cell of claim 13, wherein said cell is a human cell. ooooo
7. 13. A method for treatment of a stenotic condition by administering to a patient an enzymatic nucleic acid molecule of claims 1 or 2, or an enzymatic nucleic acid molecule which cleaves RNA produced from the gene c-myb.
8. 14. A method for treatment of a stenotic condition by administering to a patient an expression vector of e 20 claim The method of claims 13 or 14, wherein said patient is a human.
9. 16. A method for treatment of cancer by administer- ing to a patient or a patient's cells an enzymatic nucleic acid molecule of claims 1 or 2.
10. 17. A method for treatment of cancer by administer- ing to a patient or a patient's cells an expression vector of claim
11. 18. The method of claims 16 or 17, wherein said patient is a human.
12. 19. Method for administration of an enzymatic nucleic acid by mixing said nucleic acid with a chemical selected from 'the group consisting of chloroquine, ammonium chloride, carbonyl cyanide p-trifluoromethoxy phenyl hydrazone (FCCP), monensin, colchicine, amphipathic peptides, viral proteins, and viral particles. The enzymatic nucleic acid of claim 3, wherein said nucleic acid comprises of at least five ribose residues, and wherein said nucleic acid comprises phosphorothioate linkages at at least three of the six terminal nucleotides, and wherein said nucleic acid comprises a 2'-C-allyl modification at position No. 4 of said nucleic acid, and wherein said nucleic acid comprises at least ten 2'-O-methyl modifications, and wherein said nucleic acid comprises a end modification.
13. 21. The enzymatic nucleic acid of claim 20, wherein said nucleic acid comprises a linked inverted ribose moeity at said 3' end. 20 22. The enzymatic nucleic acid of claim 3, wherein said nucleic acid comprises of at least five ribose residues, and wherein said nucleic acid comprises of .phosphorothioate linkages at at least three of the six terminal nucleotides, and wherein said nucleic acid comprises a 2'-amino modification at position No. 4 and/or at position No. 7 of said nucleic acid, wherein said nucleic acid comprises at least ten 2'-O-methyl modifica- tions, and wherein said nucleic acid comprises a 3'-3' linked inverted ribose or thymidine moeity at its 3' end.
14. 23. The enzymatic nucleic acid of claim 3, wherein said nucleic acid comprises of at least five ribose residues, and wherein said nucleic acid comprises phos- phorothioate linkages at at least three of the six terminal nucleotides, and wherein said nucleic acid comprises non-nucleotide substitution at position No. 4 and/or at position No. 7 of said nucleic acid molecule, s57q wherein said nucleic acid comprises at least ten methyl modifications, and wherein said nucleic acid comprises a linked inverted ribose or thymidine moeity at its 3' end.
15. 24. The enzymatic nucleic acid of claim 3, wherein said nucleic acid comprises of at least five ribose resi- dues, and wherein said nucleic acid comprises phospho- rothioate linkages at at least three of the six 10 terminal nucleotides, and wherein said nucleic acid comprises 6-methyl uridine substitutions at position No. 4 and/or at position No. 7 of the said nucleic acid molecule, wherein said nucleic acid comprises at least ten 2'-O-methyl modifications, and wherein said nucleic acid comprises a linked inverted ribose or thymidine moeity at its 3' end. The enzymatic nucleic acid of claim 3, wherein said nucleic acid comprises of at least five ribose S 20 residues, and wherein said nucleic acid comprises phos- phorothioate linkages at at least three of thje six S:terminal nucleotides, wherein said nucleic acid comprises 2'-C-allyl modification at position No. 4 of the said nucleic acid, wherein said nucleic acid comprises at least ten 2'-O-methyl modifications, and wherein said nucleic acid comprises a linked inverted ribose or thymidine moeity at its 3' end.
16. 26. Oligonucleotide having complementarity to c-myb at at least 5 contiguous bases comprising a adenylate residue having a
17. 27. The oligonucleotide of claim 26, having enzymatic activity on c-myb RNA.
18. 28. The oligonucleotide of claim 26, comprising at least 20 bases able to form a hybrid with c-myb RNA. 1. An enzymatic nucleic acid molecule which cleaves c-myb RNA, said nucleic acid molecule having binding arms and wherein said binding arms contain sequences complementary to the sequences defined in Tables II, XIII-XXIV. 2. The enzymatic nucleic acid molecule of claim 1 wherein said nucleic acid molecule is in a hammerhead motif. 3. The enzymatic nucleic acid molecule of claim 1, wherein said nucleic acid molecule is in a hairpin, hepatitis delta virus, VS nucleic acid. group I intron, or RNAseP nucleic acid motif. 1 4. The enzymatic nucleic acid molecule of claim 2 or claim 3, wherein said nuclcic acid comprises between 12 and 100 bases complementary to said mRNA. An enzymatic nucleic acid molecule of claim 4. wherein said nucleic acid S comprises between 14 and 24 bases complementary to said mRNA. 6. An enzymatic nucleic acid molecule of claim I consisting essentially of 5 any sequence selected from the group of sequences listed in Tables 1II, XIII-XXIV. 7. A mammalian cell including an enzymatic nucleic acid molecule of any one of claims 1-6. 8. The cell of claim 7, wherein said cell is a human cell. 9. An expression vector including nucleic acid encoding an enzymatic nucleic acid molecule or multiple enzymatic molecules of any one of claims 1-6 in a manner which allows expression of that enzymatic RNA molecule(s) within a mammalian cell. 10. A mammalian cell including an expression vector of claim 9. 1 1. The cell of claim 10, wherein said cell is a human cell. 12. A method for treatment of a stenotic condition by administering to a ,3 patient an enzymatic nucleic acid molecule of any one of claims 1-6. 13. A method for treatment of a stenotic condition by administering to a patient an expression vector of claim 9. 14. The method of claims 12 or 13, wherein said patient is a human. A method for treatment of cancer by administering to a patient or a patient's cell an enzymatic nucleic acid molecule of any one of claims 1-6. 16. A method for treatment of cancer by administering to a patient or a patient's cells an expression vector of claim 9. 17. The method of claims 15 or 16, wherein said patient is a human. 18. Method for administration of an enzymatic nucleic acid molecule of any 3 one of claims 1-6 by mixing said nucleic acid molecule with a chemical selected from the group consisting of chloroquine, ammonium chloride, carbonyl cyanide p-trifluoromethoxy [I:\DAYLIB\-IBAj02662.doc:tlI phenyl hydrazone (FCCP), monensin, colchicine, amphipathic peptides, viral proteins, and viral particles. 19. The enzymatic nucleic acid of claim 2, wherein said nucleic acid comprises at least five ribose residues, and wherein said nucleic acid comprises phosphorothioate linkages at at least three 5' terminal nucleotides, and wherein said nucleic acid comprises a 2 '-C-allyl modification at position No. 4 of said nucleic acid, and wherein said nucleic acid comprises at least ten 2'-0-methyl modifications. The enzymatic nucleic acid of claim 19, wherein said nucleic acid comprises a linked inverted ribose moiety at said 3' end. 21. The enzymatic nucleic acid of claim 2, wherein said nucleic acid comprises at least five ribose residues, and wherein said nucleic acid comprises phosphorothioate linkages at at least three 5' terminal nucleotides. and wherein said nucleic .acid comprises a 2 '-amino modification at position No. 4 and/or at position No. 7 of said nucleic acid, wherein said nucleic acid comprises at least ten 2'-O-methyl modifications. 5 22. The enzymatic nucleic acid of claim 2, wherein said nucleic acid comprises at least five ribose residues, and wherein said nucleic acid comprises phosphorothioate linkages at at least three 5' terminal nucleotides, and wherein said nucleic acid comprises abasic substitution at position No. 4 and/or at position No. 7 of said nucleic acid molecule, wherein said nucleic acid comprises at least ten 2 '-0-methyl modifications. 20 23. The enzymatic nucleic acid of claim 2. wherein said nucleic acid comprises at least five ribose residues, and wherein said nucleic acid comprises phosphorothioate linkages at at least three 5' terminal nucleotides, and wherein said nucleic acid comprises 6-methyl uridine substitutions at position No. 4 and/or at position No. 7 of the said nucleic acid molecule, wherein said nucleic acid comprises at least ten 2- modifications. 24. The enzymatic nucleic acid of claim 2. wherein said nucleic acid comprises at least five ribose residues, and wherein said nucleic acid comprises phosphorothioate linkages at at least three 5' terminal nucleotides, and wherein said nucleic acid comprises 2'-C-allyl modification at position No. 4 of the said nucleic acid, wherein said nucleic acid comprises at least ten 2 '-O-methyl modifications. An enzymatic nucleic acid molecule of claim 1 having complementarity to c-myb RNA at at least 5 contiguous bases comprising a 2 '-5'-linked adenylate residue having a 5'-phosphate, wherein said enzymatic nucleic acid molecule has enzymatic activity on c-myb RNA. 3 26. The enzymatic nucleic acid molecule of claim 25, comprising at least bases able to hydridize with c-myb RNA. [I:\DAYLIB\LIBA]02662.doc:tlt 5S82 27. An enzymatic nucleic acid molecule which cleaves c-myb RNA at any of the RNA sequences defined in Tables II, XIII-XXIV, substantially as hereinbefore described with reference to any one of Examples 4-25. 28. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 232.
19. 29. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 264. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 266. 3 2 The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 272.
20. 32. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic :9 nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 282. 3 4 The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic Snucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 320. 3, 33. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic s nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 300. 2
21. 35. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic S nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 3740.
22. 36. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 384. S37. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 324.
23. 39. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 542. 34. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 532. S410. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 530. 4. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 93.
24. 42. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 93.
25. 43. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 572. [I:\DAYLIB\LIBAj02662.doc:tIt
26. 44. The enzymatic nucleic acid molecule of claim- 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 614.
27. 46. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 622.
28. 47. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 98.
29. 48. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic i0 nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1162. 1164. 1166 or 1168.
30. 49. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1170. 1174or 1176. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID 0 NOS. 1178,
31. 51. nucleic acid 20 NOS. 1 186,
32. 52. nucleic acid NOS. 1194,
33. 53. nucleic acid 1180, 1182 or 1184. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic molecule specifically cleaves any of the RNA sequences defined as SEQ ID 1188, 1190 or 1192. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic molecule specifically cleaves any of the RNA sequences defined as SEQ ID 1196, 1198 or 1200 The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1202, 1204, 1206 or 1208.
34. 54. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1210, 1212, 1214 or 1216. '0
35. 55. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1218, 1220, 1222 or 1224.
36. 56. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 930, 932, 934 or 936. [I:\DAYLIB\LIBA]02662doc:tt
37. 57. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 938, 940, 942 or 944.
38. 58. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 946, 948, 950 or 952.
39. 59. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 954. 956, 958 or 960. I
40. 60. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 962. 964, 966 or 968. .61. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID S NOS. 970, 972, 974 or 976.
41. 62. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 978. 980, 982 or 984.
42. 63. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic 20 nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 986. 988, 990 or 992.
43. 64. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 994, 996, 998 or 1000. 5
44. 65. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1002, 1004, 1006, 1008 or 1010.
45. 66. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID Th NOS. 1012, 1014 or 1018.
46. 67. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1020, 1022, 1024 or 1026.
47. 68. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic 3s nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1028, 1030, 1032 or 1034. I :\DAYLIB\LIBAj02662.doc:tit
48. 69. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1036, 1038, 1040 or 1042. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1042. 1044, 1046 or 1048.
49. 71. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1050. 1052, 1054 or 1056. 1
50. 72. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1058, 1060, 1062 or 1064.
51. 73. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID i NOS. 1066, 1068, 1070 or 1072.
52. 74. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1074, 1076, 1078 or 1080.
53. 75. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1082, 1084, 1086 or 1088.
54. 76. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic o" nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1090. 1092, 1094 or 1096.
55. 77. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1098. 1100, 1102 or 1104.
56. 78. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID S NOS. 1106, 1108, 1110 or 1112.
57. 79. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1114, 1116. 1118 or 1120. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic 3. nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1122, 1124, 1126 or 1128. II :\DAYLIB\LI BA]02662,doc lt
58. 81. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1130, 1132, 1134 or 1136.
59. 82. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1138, 1140, 1142 or 1144.
60. 83. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 170. 172, 174 or 176.
61. 84. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 178. 180, 182 or 184. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 186. 188, 190 or 192.
62. 86. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 194, 196, 198 or 200.
63. 87. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic S 2 nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 202. 204, 206 or 208.
64. 88. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic "IL nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 210. 212, 214 or 216. 8* 89. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 218. 220, 222 or 224. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 226. 228 or 230.
65. 91. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 234. 236, 238 or 240.
66. 92. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 242, 246 or 248. [I:\DAYLI\IABA]02662.doc1It
67. 93. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 250, 252, 254 or 256.
68. 94. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 258. 260 or 262. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 268 or 270. i"
69. 96. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 274. 278 or 280.
70. 97. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID is NOS. 284. 286 or 288.
71. 98. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 290. 292. 294 or 296.
72. 99. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic S2 ncleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 298. 302 or 304.
73. 100. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 306. 3 08, 310 or 312. fa 25 101. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 314. 3 16 or 318.
74. 102. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID us NOS. 322, 324, 326 or 328.
75. 103. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 330, 332, 334 or 336.
76. 104. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 338, 342 or 344. [:\DAYLI B\IBA]02662.doc:tlt
77. 105. The enzymatic nucleic acid molecule of claimi 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 346, 348 or 352.
78. 106. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 354, 356, 358 or 360.
79. 107. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 362. 364, 366 or 368.
80. 108. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 370, 372 or 376.
81. 109. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic I nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 380 or 382. 10. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 386, 388, 390 or 392.
82. 111. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 394, 396 or 400.
83. 112. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 402, 404, 406 or 408. 25
84. 113. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 410, 412, 4 14 or 416.
85. 114. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 418, 420, 422 or 424.
86. 115. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 426, 428, 430 or 432.
87. 116. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic 3S nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 434, 436, 438 or 440. I :\DAYLIB\L1BA]02662.doc:tIt
88. 117. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 444, 446 or 448.
89. 118. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 450, 452, 454 or 456.
90. 119. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 458, 460, 462 or 464. I, 120. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 446. 468. 470 or 472.
91. 121. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID Si NOS. 474, 476. 478 or 480.
92. 122. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 482. 484, 486 or 488. :123. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic a, nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 490. 492, 494 or 496.
93. 124. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 498. 500, 502 or 504. 25 125. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 506. 508, 510 or 512.
94. 126. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequence defined as SEQ ID NOS. 514, 516, 518 or 520.
95. 127. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 524, 526 or 528.
96. 128. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic Snucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 530, 532, 534 or 536. [I:\DAYLIB\LIBA02662.doc:tlt
97. 129. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 540, 542 or 544.
98. 130. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 546, 548, 550 or 552.
99. 131. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 554. 556. 558 or 560.
100. 132. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 562. 564, 566 or 568.
101. 133. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic S* nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 570 or 574.
102. 134. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 578, 580, 582 or 584.
103. 135. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic 0* 20 nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 586. 588, 590 or 592.
104. 136. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 594. 596, 598 or 600. 5
105. 137. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 602. 604. 606 or 608.
106. 138. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID SNOS. 610, 612 or 616.
107. 139. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 618, 620 or 624.
108. 140. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic 3- nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 626, 628, 630 or 632. fI:\DAYLI\LIBA1U2662.doc:tII
109. 141. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic O nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 634. 638, 640 or 642.
110. 142. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 644. 646, 648 or 670.
111. 143. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 672. 674. 676 or 678.
112. 144. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 680. 682. 684 or 686.
113. 145. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic n l ucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID s 15 NOS.
114. 688. 690. 692 or 694. 146. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 696. 698. 700 or 702. 147. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic 2( nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 407. 706, 708 or 710. 148. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 712. 714, 7 16 or 718. 5 149. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 720. 722 724 or 726. 150. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 728. 730. 732 or 734. 151. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 736. 738. 740 or 742. 152. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 744, 746, 748 or 750. I I:\DAYIJI \LiBA]02662docit 5c42 153. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 752, 754, 756 or 758. 154. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 760, 762, 764 or 766. 155. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 778, 780, 782 or 784. 156. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 786, 788, 790 or 792. 157. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 794. 796, 798 or 800. 158. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 802, 804, 806 or 808. 59. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 810, 812, 814 or 816. 160. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 818, 820, 822 or 824. 161. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 826. 828, 830 or 832. 162. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID H; NOS. 834, 836, 838 or 840. 163. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 844, 846 or 848. 164. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic Snucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 850, 852 or 854. II :\DAYHIB\LBA102662 .doc:tt c:° 165. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 858, 860, 862 or 864. 166. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 866, 868, 870 or 872. 167. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 874, 876, 878 or 880. i, 168. The enzymatic nucleic acid molecule of claim 2. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 882, 884, 886 or 888. 169. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID 5 I NOS. 890, 892, 894 or 896. 170. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic o. nucleic acid molecule specifically cleaves any of the RNA sequences identified as SEQ ID NOS. 898, 900, 902 or 904. 171. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic 2~0 nucleic acid molecule specifically cleaves any of the RNA sequences defined as SQ ID NOS. 906, 908, 910 or 912. 172. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 914, 916, 918 or 920. 2. 173. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 922, 924, 926 or 928. 174. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID w0 NOS. 1146, 1150 or 1152. 175. The enzymatic nucleic acid molecule of claim 2, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 1154, 1156, 1158 or 1160. 176. The enzymatic nucleic acid molecule of claim 3, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID [I xLI B\LI BAjo2662 doc:tlt q4- NOS. 99, 100 or 130-148, wherein said enzymatic nucleic acid molecule is in a hairpin motif. 177. The enzymatic nucleic acid molecule of claim 176, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 99. 178. The enzymatic nucleic acid molecule of claim 176. wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID NO. 100. 179. The enzymatic nucleic acid molecule of claim 176. wherein said I1 enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 130-133. 180. The enzymatic nucleic acid molecule of claim 176. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 134-137. S I 181. The enzymatic nucleic acid molecule of claim 176, wherein said enzymatic nucleic acid molecule specifically cleaves the RNA sequence defined as SEQ ID S. NO. 138. 182. The enzymatic nucleic acid molecule of claim 176. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as 20 S ID NOS. 139-141. I N 1 l) 1 H 183. The enzymatic nucleic acid molecule of claim 176. wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 142-145. 184. The enzymatic nucleic acid molecule of claim 176, wherein said enzymatic nucleic acid molecule specifically cleaves any of the RNA sequences defined as SEQ ID NOS. 146-148. 185. The enzymatic nucleic acid molecule of claim 3 consisting of any sequence selected from the group of SEQ ID NOS. 121, 122, 149-167. 186. The enzymatic nucleic acid molecule of claim 1, wherein said molecule M0 has binding arms and wherein the binding arms of said enzymatic nucleic acid molecule contain sequences perfectly complementary to any of the RNA sequences defined as SEQ ID. NOS. 79-98, 101-120 or 123-129, wherein said enzymatic nucleic acid molecule is in a hammerhead motif. 187. The enzymatic nucleic acid molecule of claim 3, wherein said molecule has binding arms and wherein the binding arms of said enzymatic nucleic acid molecule contain sequences perfectly complementary to any of the RNA sequences defined as SEQ [I :\DAYLIB\LIBA]02662.doc:tt ID. NOS. 99, 100 or 130-148, wherein said enzymatic nucleic acid molecule is in a hairpin motif. 188. A mammalian cell including an enzymatic nucleic acid molecule of any one of claims 19-187. 189. The cell of claim 188 wherein said cell is a human cell. 190. An expression vector including nucleic acid encoding an enzymatic nucleic acid molecule or multiple enzymatic molecules of any one of claims 19-187 in a manner which allows expression of that enzymatic RNA molecule(s) within a mammalian cell. I, 191. A mammalian cell including an expression vector of claim 190. 192. The cell of claim 191 wherein said cell is a human cell. 193. The use of an enzymatic nucleic acid molecule of any one of claims 1-6 or 9-187. for the manufacture of a medicament for the treatment of a stenotic condition in a patient. I: 194. The use of an expression vector of claim 190 in the manufacture of a miedicament for the treatment of a stenotic condition in a patient. 195. The use of an enzymatic nucleic acid molecule of any one of claims 1-6 or 19-187. for the manufacture of a medicament for the treatment of cancer in a patient. 196. The use of an expression vector of claim 190 in the manufacture of a 20 medicament for the treatment of cancer in a patient. 197. The use of any one of claims 193-196 wherein said patient is a human. 198. An enzymatic nucleic acid molecule of any one of claims 1-6 or 19-187, too. when used in the treatment of a stenotic condition in a patient. 199. An expression vector of claim 190 when used in the treatment of a stenotic condition in a patient. S 200. An enzymatic nucleic acid molecule of any one of claims 1-6 or 19-187 when used in the treatment of cancer in a patient. 201. An expression vector of claim 190 when used in the treatment of cancer in a patient. 3I 202. The nucleic acid molecule or expression vector of any one of claims 198- 201 wherein said patient is a human. 203. A method of treating a stenotic condition in a patient by administering to said patient an enzymatic nucleic acid molecule of any one of claims 19-187. 204. A method of treating a stenotic condition in a patient by administering to said patient an expression vector of claim 190. [I :\DAYLI\LI BA02662.doc t 596 S205. A method of treating cancer in a patient by administering to said patient or said patient's cells an enzymatic nucleic acid molecule of any one of claims 19-187. 206. A method of treating cancer in a patient by administering to said patient or said patient's cells an expression vector of claim 190. 207. The method of any one of claims 203-206 wherein said patient is a human. 208. A method for administration of an enzymatic nucleic acid molecule of any one of claims 19-187 by mixing said nucleic acid molecule with a chemical selected from the group consisting of chloroquine, ammonium chloride, carbonyl cyanide p- trifluoromethoxy phenyl hydrazone (FCCP), monensin, colchicine, amphipathic peptides, I) viral proteins, and viral particles. 209. A formulation comprising a mixture of an enzymatic nucleic acid molecule of any one of claims 1-6 or 19-187 and a chemical selected from the group consisting of chloroquine, ammonium chloride, carbonyl cyanide p-trifluoromethoxy phenyl hydrazone (FCCP), monensin, colchicine, amphipathic peptides, viral proteins, and viral 15 particles. Dated 13 July, 1999 S Ribozyme Pharmaceuticals, Inc e o* S• Patent Attorneys for the Applicant/Nominated Person SPRUSON FERGUSON •tt•• [1:\DAYLB\LBAj02662.doc:tlt