AU3750989A - One-step chromatographic purification of immunotoxin conjugates using a thiophilic matrix - Google Patents

One-step chromatographic purification of immunotoxin conjugates using a thiophilic matrix

Info

Publication number
AU3750989A
AU3750989A AU37509/89A AU3750989A AU3750989A AU 3750989 A AU3750989 A AU 3750989A AU 37509/89 A AU37509/89 A AU 37509/89A AU 3750989 A AU3750989 A AU 3750989A AU 3750989 A AU3750989 A AU 3750989A
Authority
AU
Australia
Prior art keywords
thiophilic
matrix
chromatographic purification
step chromatographic
immunotoxin conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU37509/89A
Inventor
Robert Ferris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of AU3750989A publication Critical patent/AU3750989A/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6819—Plant toxins
    • A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
    • A61K47/6827—Ricin A
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B01J20/267—Cross-linked polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU37509/89A 1988-06-01 1989-05-26 One-step chromatographic purification of immunotoxin conjugates using a thiophilic matrix Abandoned AU3750989A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20079788A 1988-06-01 1988-06-01
US200797 1994-02-23

Publications (1)

Publication Number Publication Date
AU3750989A true AU3750989A (en) 1990-01-05

Family

ID=22743229

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37509/89A Abandoned AU3750989A (en) 1988-06-01 1989-05-26 One-step chromatographic purification of immunotoxin conjugates using a thiophilic matrix

Country Status (2)

Country Link
AU (1) AU3750989A (en)
WO (1) WO1989011871A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1249051B (en) * 1991-02-26 1995-02-11 Italfarmaco Spa IMMUNOTOXIN FROM ANTI-CD5 MONOCLONAL ANTIBODIES
US5502022A (en) 1994-05-16 1996-03-26 Biosepra, Inc. Chromatography adsorbents utilizing mercapto heterocyclic ligands

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE470099B (en) * 1984-05-17 1993-11-08 Jerker Porath Sulfone activated thioether adsorbents for separation of eg protein
US4771128A (en) * 1986-10-10 1988-09-13 Cetus Corporation Method of purifying toxin conjugates using hydrophobic interaction chromatography

Also Published As

Publication number Publication date
WO1989011871A1 (en) 1989-12-14

Similar Documents

Publication Publication Date Title
AU5060893A (en) Steering column clamping mechanism
AU619328B2 (en) Cytotoxic drug conjugates
AU2300092A (en) Prostaglandin e2 treatment of impotence
AU619329B2 (en) Cytotoxic drug conjugates
AU6992891A (en) A support column
AU8691491A (en) A column unit
AU4451389A (en) Antibody-drug conjugates
AU8804991A (en) A telescopically length variable steering column
AU4852396A (en) Column for chromatography
AU7006596A (en) Using hydrocarbon streams to prepare a metallic protective l ayer
AU7821591A (en) Column planter
AU666419B2 (en) Relocated pivoting moistener column for a cotton picker
AU3750989A (en) One-step chromatographic purification of immunotoxin conjugates using a thiophilic matrix
AU1288188A (en) Immunoglobulin conjugates
AU3170293A (en) Therapeutic nucleosides
AU4508493A (en) Therapeutic nucleosides
AU5768896A (en) Steering column clamping mechanism
AU3361389A (en) Steering rod for a bicycle
AU3518693A (en) Therapeutic earring
IL89047A0 (en) Thiophilic adsorbents
AU3336489A (en) A support bracket
HUT67317A (en) Strain clamp for yield roadway supports
AU638971B2 (en) Anthracycline immunoconjugates having a novel linker and methods for their production
AU4475396A (en) A therapeutic molecule
AUPN078495A0 (en) A therapeutic molecule