AU3725697A - Infectious papillomavirus pseudoviral particles - Google Patents
Infectious papillomavirus pseudoviral particlesInfo
- Publication number
- AU3725697A AU3725697A AU37256/97A AU3725697A AU3725697A AU 3725697 A AU3725697 A AU 3725697A AU 37256/97 A AU37256/97 A AU 37256/97A AU 3725697 A AU3725697 A AU 3725697A AU 3725697 A AU3725697 A AU 3725697A
- Authority
- AU
- Australia
- Prior art keywords
- gene
- biological species
- papillomavirus
- derived
- pseudoviral particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241001631646 Papillomaviridae Species 0.000 title abstract 4
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 230000002458 infectious effect Effects 0.000 title abstract 2
- 239000002245 particle Substances 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 241000894007 species Species 0.000 abstract 4
- 101710172711 Structural protein Proteins 0.000 abstract 2
- 210000000234 capsid Anatomy 0.000 abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
- Y10S977/916—Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention provides an infectious papillomavirus pseudoviral particle useful in gene transfer comprising: (a) a papillomavirus vector DNA which comprises an E2 binding site and an expression cassette comprising a gene and a sequence controlling expression of said gene; and (b) a papillomavirus capsid which comprises L1 and L2 structural proteins, such that said capsid encapsidates said vector DNA, wherein said gene is derived from a first biological species and said L1 structural protein is derived from a second biological species and said first biological species is different from said second biological species.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2210496P | 1996-07-17 | 1996-07-17 | |
US60/022104 | 1996-07-17 | ||
PCT/US1997/012115 WO1998002548A2 (en) | 1996-07-17 | 1997-07-14 | Infectious papillomavirus pseudoviral particles |
Publications (2)
Publication Number | Publication Date |
---|---|
AU3725697A true AU3725697A (en) | 1998-02-09 |
AU732125B2 AU732125B2 (en) | 2001-04-12 |
Family
ID=21807834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU37256/97A Expired AU732125B2 (en) | 1996-07-17 | 1997-07-14 | Infectious papillomavirus pseudoviral particles |
Country Status (8)
Country | Link |
---|---|
US (2) | US6599739B1 (en) |
EP (1) | EP0922105B1 (en) |
JP (1) | JP2000515741A (en) |
AT (1) | ATE312178T1 (en) |
AU (1) | AU732125B2 (en) |
CA (1) | CA2257822A1 (en) |
DE (1) | DE69734829D1 (en) |
WO (1) | WO1998002548A2 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7476517B2 (en) | 1999-06-30 | 2009-01-13 | Evotec Ag | Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics |
US20040014033A1 (en) | 1999-06-30 | 2004-01-22 | Evotec Biosystems Ag, A Corporation Of Germany | Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics |
JP2003504014A (en) * | 1999-06-30 | 2003-02-04 | エボテック オーアーイー アクチェンゲゼルシャフト | Viral particles, their preparation and preferably their use in pharmaceutical screening and functional genomes |
GB0007231D0 (en) | 2000-03-24 | 2000-05-17 | Chiron Spa | Modified rna for gene delivery |
CA2415763A1 (en) * | 2000-07-07 | 2002-01-17 | Merck & Co., Inc. | Production of chimeric human papillomavirus |
FI116851B (en) | 2001-05-03 | 2006-03-15 | Fit Biotech Oyj Plc | Expression vector, its uses and process for its preparation and products containing it |
CN1114690C (en) * | 2001-05-15 | 2003-07-16 | 乔良 | Papilloma pseudovirus and process for preparing same |
US7247433B2 (en) | 2001-08-13 | 2007-07-24 | University Of Rochester | Transcutaneous immunization against papillomavirus with papillomavirus virus-like particles |
ITVA20050021A1 (en) | 2005-04-01 | 2006-10-02 | Sergio Biucchi | OFF-LINE COMPUTER DEVICES FOR THE SYSTEM OF SELF-MANAGED CURRENCY TRANSACTIONS |
WO2007064971A2 (en) * | 2005-12-01 | 2007-06-07 | The Government Of The Usa, As Represented By The Secretary, Dept. Of Health & Human Services | Infectious papovavirus particle comprising a cytocidal gene and methods of use thereof |
US8778351B2 (en) | 2006-08-30 | 2014-07-15 | University Of Rochester | Combined human papillomavirus VLP/gene delivery system and use thereof as a vaccine for prophylaxis and immunotherapy of infectious diseases and tumors |
ES2653251T3 (en) * | 2009-04-10 | 2018-02-06 | The Johns Hopkins University | Particles of the papillomavirus (VLP) type as broad-spectrum human papillomavirus (HPV) vaccines |
US9724404B2 (en) * | 2009-04-13 | 2017-08-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | HPV particles and uses thereof |
WO2011017162A2 (en) * | 2009-08-03 | 2011-02-10 | The Johns Hopkins University | Methods for enhancing antigen-specific immune responses |
EA201592264A1 (en) * | 2009-08-26 | 2016-08-31 | Селекта Байосайенсиз, Инк. | COMPOSITIONS WHICH INDUCE T-CELL HELPER EFFECT |
WO2013119877A1 (en) | 2012-02-07 | 2013-08-15 | Aura Biosciences, Inc. | Virion-derived nanospheres for selective delivery of therapeutic and diagnostic agents to cancer cells |
WO2015042325A1 (en) | 2013-09-18 | 2015-03-26 | Aura Biosciences, Inc. | Virus-like particle conjugates for diagnosis and treatment of tumors |
MA43134A (en) | 2015-10-30 | 2018-09-05 | Aleta Biotherapeutics Inc | COMPOSITIONS AND METHODS OF TUMOR TRANSDUCTION |
CA3002674A1 (en) | 2015-10-30 | 2017-05-04 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
CN108473950A (en) | 2015-10-30 | 2018-08-31 | 美国政府卫生与公众服务部 | Targeted cancer therapy |
DE102016215500B4 (en) * | 2016-08-18 | 2020-02-20 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Sensor system for characterizing the state of samples of a heterogeneous biomass structure contained in a culture vessel |
US20200330582A1 (en) | 2017-11-06 | 2020-10-22 | The Usa, As Represented By The Secretary, Department Of Health And Human Services | Cancer treatment utilizing pre-existing microbial immunity |
CN116350803B (en) * | 2023-05-19 | 2023-11-24 | 健通(济南)生物科技有限公司 | mRNA drug delivery system taking papillomavirus-like particles as carrier and preparation method thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5437951A (en) | 1992-09-03 | 1995-08-01 | The United States Of America As Represented By The Department Of Health And Human Services | Self-assembling recombinant papillomavirus capsid proteins |
US5618536A (en) | 1992-09-03 | 1997-04-08 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric papillomavirus-like particles |
US5792931A (en) * | 1994-08-12 | 1998-08-11 | Pioneer Hi-Bred International, Inc. | Fumonisin detoxification compositions and methods |
PT809700E (en) | 1994-10-07 | 2006-09-29 | Univ Loyola Chicago | PARTICLES SIMILAR TO PAPILLOMAVIRUS AND FUSEOUS PROTEINS, AND METHODS FOR THEIR PRODUCTION |
FR2749323B1 (en) | 1996-06-04 | 1998-07-10 | Pasteur Merieux Serums Vacc | PSEUDO-PARTICLES VIRALES USEFUL AS A VECTOR OF NUCLEIC ACID DELIVERY |
DK1015561T3 (en) * | 1997-09-05 | 2006-11-13 | Medimmune Inc | In vitro method for separation / re-assembly of papillomavirus-like particles (VLPs) |
-
1997
- 1997-07-14 AU AU37256/97A patent/AU732125B2/en not_active Expired
- 1997-07-14 WO PCT/US1997/012115 patent/WO1998002548A2/en active IP Right Grant
- 1997-07-14 EP EP97934126A patent/EP0922105B1/en not_active Expired - Lifetime
- 1997-07-14 DE DE69734829T patent/DE69734829D1/en not_active Expired - Lifetime
- 1997-07-14 US US09/509,748 patent/US6599739B1/en not_active Expired - Lifetime
- 1997-07-14 JP JP10506187A patent/JP2000515741A/en not_active Withdrawn
- 1997-07-14 CA CA002257822A patent/CA2257822A1/en not_active Abandoned
- 1997-07-14 AT AT97934126T patent/ATE312178T1/en not_active IP Right Cessation
-
2003
- 2003-05-27 US US10/446,060 patent/US20030207446A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1998002548A2 (en) | 1998-01-22 |
CA2257822A1 (en) | 1998-01-22 |
ATE312178T1 (en) | 2005-12-15 |
DE69734829D1 (en) | 2006-01-12 |
EP0922105B1 (en) | 2005-12-07 |
JP2000515741A (en) | 2000-11-28 |
EP0922105A2 (en) | 1999-06-16 |
AU732125B2 (en) | 2001-04-12 |
US6599739B1 (en) | 2003-07-29 |
WO1998002548A3 (en) | 1998-03-05 |
US20030207446A1 (en) | 2003-11-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FGA | Letters patent sealed or granted (standard patent) |