AU3632000A - Treatment of certain cancers associated with weight gain - Google Patents
Treatment of certain cancers associated with weight gain Download PDFInfo
- Publication number
- AU3632000A AU3632000A AU36320/00A AU3632000A AU3632000A AU 3632000 A AU3632000 A AU 3632000A AU 36320/00 A AU36320/00 A AU 36320/00A AU 3632000 A AU3632000 A AU 3632000A AU 3632000 A AU3632000 A AU 3632000A
- Authority
- AU
- Australia
- Prior art keywords
- compound
- formula
- cyclobutyl
- chlorophenyl
- methylbutylamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Description
WO 00/56323 PCT/USOO/07361 Treatment of Certain Cancers Associated with Weight Gain 5 This invention relates to a method of treating certain cancers associated with weight gain. According to the present invention there is provided a method of controlling ceertain cancers associated with weight gain, in which a 10 therapeutically effective amount of a compound of formula I
CH
3 CI
H
3
CC;HCH
2
CHNR
1
R
2 including enantiomers and pharmaceutically acceptable salts thereof, in which R 1 15 and R 2 are independently H or methyl, is administered in conjunction with a pharmaceutically acceptable diluent or carrier to a human in need thereof. Cancers which may advantageously be treated with a compound of formula I include colon cancer, breast cancer, endometrial cancer and 20 gallbladder cancer. A preferred compound of formula I is N,_N-dimethyl-1-[1-(4 chlorophenyl)cyclobutyl]-3-methylbutylamine or a salt thereof, for example the hydrochloride salt. A preferred form of this hydrochloride is its monohydrate. 25 The preparation and use of compounds of formula I, such as N,N dimethyl-1-[1-( 4 -chlorophenyl)cyclobutyl]-3-methylbutylamine, N-{1-[1-(4 SUBSTITUTE SHEET (RULE 26) WO 00/56323 PCT/USOO/07361 chlorophenyl)-cyclobutyl]-3-methylbutyl}-N-methylamine, and 1-[1-(4 chlorophenyl)-cyclobutyl]-3-methylbutylamine and salts thereof, in the treatment of depression is described in British Patent Specification 2098602 and US Patent 4,522,328. The use of compounds of formula I such as NN-dimethyl-1-[1-(4 5 chlorophenyl)cyclobutyl]-3-methylbutylamine and salts thereof in the treatment of Parkinson's disease is described in published PCT application WO 88/06444. The use of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine and salts thereof in the treatment of cerebral function disorders is described in US Patent 4,939,175. The use of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3 10 methylbutylamine hydrochloride in the treatment of obesity is described in published PCT application W090/061 10. A particularly preferred form of this compound is N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate (sibutramine hydrochloride) which is described in European Patent Number 230742. The use of N,N-dimethyl-1-[1-(4 15 chlorophenyl)cyclobutyl]-3-methylbutylamine and salts thereof for improving the glucose tolerance of humans having Impaired Glucose Tol'erance or Non-Insulin Dependent Diabetes Mellitus is described in published PCT application W095/20949. 20 It will be appreciated by those skilled in the art that compounds of formula I contain a chiral centre. When a compound of formula I contains a single chiral centre it may exist in two enantiomeric forms. The present invention includes the use of the individual enantiomers and mixtures of the enantiomers. The enantiomers may be resolved by methods known to those skilled in the art, for 25 example by formation of diastereoisomeric salts or complexes which may be separated, for example, by crystallisation; via formation of diastereoisomeric derivatives which may be separated, for example, by crystallisation, gas-liquid or liquid chromatography; selective reaction of one enantiomer with an enantiomer specific reagent, for example enzymatic oxidation or reduction, followed by 30 separation of the modified and unmodified enantiomers; or gas-liquid or liquid 2 SUBSTITUTE SHEET (RULE 26) WO 00/56323 PCTUSOO/07361 chromatography in a chiral environment, for example on a chiral support, for example silica with a bound chiral ligand or in the presence of a chiral solvent. It will be appreciated that where the desired enantiomer is converted into another chemical entity by one of the separation procedures described above, a further 5 step is required to liberate the desired enantiomeric form. Alternatively, specific enantiomers may be synthesised by asymmetric synthesis using optically active reagents, substrates, catalysts or solvents, or by converting one enantiomer to the other by asymmetric transformation. 10 Preferred compounds of formula I are NN-dimethyl-1-[1-(4-chlorophenyl) cyclobutyl]-3-methylbutylamine, N-{1-[1-(4-chlorophenyl)cyclobutyl]-3 methylbutyl}-N- methylamine, and 1-[l-(4-chlorophenyl)cyclobutyl]-3 methylbutylamine including racemates, individual enantiomers and mixtures thereof, and pharmaceutically acceptable salts thereof. 15 The individual enantiomers can be prepared by enantioselective synthesis from optically active precursors, or by resolving the racemic compound which can be prepared as described above. Enantiomers of secondary amines of the formula I can also be prepared by preparing the racemate of the corresponding 20 primary amine, resolving the latter into the individual enantiomers, and then converting the optically pure primary amine enantiomer into the required secondary amine by methods described in British Patent Specification 2098602. Specific examples of compounds of formula I are: 25 (+)-N-[1 -[1 -(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N-methylamine; (-)-N-{l -[1 -(4-chlorophenyl)cyclobutyl-3-methylbutyl}-N-methylamine; (+)-1 -[1 -(4-chlorophenyl)cyclobutyl]-3-methylbutylamine; (-)-1 -[1 -(4-chlorophenyl)cyclobutyl]-3-methylbutylamine; 30 (+)-N-{l -[1 -(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N-N-dimethylamine; 3 SUBSTITUTE SHEET (RULE 26) WO 00/56323 PCT/USOO/07361 (-)-N-{1-[1 -(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N-N-dimethylamine. The hydrochloride salts are preferred in each case, but the free bases and other pharmaceutically acceptable salts are also suitable. 5 The compound of formula I may be administered in any of the known pharmaceutical dosage forms. The amount of the compound to be administered will depend on a number of factors including the age of the patient, the severity of the condition and the past medical history of the patient and always lies within the 10 sound discretion of the administering physician but it is generally envisaged that the dosage of the compound to be administered will be in the range 0.1 to 50 mg preferably 1 to 30 mg per day given in one or more doses. Oral dosage forms are the preferred compositions for use in the present 15 invention and these are the known pharmaceutical forms for such administration, for example tablets, capsules, granules, syrups and aqueous or oil suspensions. The excipients used in the preparation of these compositions are the excipients known in the pharmacist's art. Tablets may be prepared from a mixture of the active compound with fillers, for example calcium phosphate; disintegrating 20 agents, for example maize starch; lubricating agents, for example magnesium stearate; binders, for example microcrystalline cellulose or polyvinylpyrrolidone and other optional ingredients known in the art to permit tableting the mixture by known methods. The tablets may, if desired, be coated using known methods and excipients which may include enteric coating using for example 25 hydroxypropylmethylcellulose phthalate. The tablets may be formulated in a manner known to those skilled in the art so as to give a sustained release of the compounds of the present invention. Such tablets may, if desired, be provided with enteric coatings by known methods, for example by the use of cellulose acetate phthalate. Similarly, capsules, for example hard or soft gelatin capsules, 30 containing the active compound with or without added excipients, may be 4 SUBSTITUTE SHEET (RULE 26) WO 00/56323 PCT/USOO/07361 prepared by known methods and, if desired, provided with enteric coatings in a known manner. The contents of the capsule may be formulated using known methods so as to give sustained release of the active compound. The tablets and capsules may conveniently each contain 1 to 50 mg of the active compound. 5 Other dosage forms for oral administration include, for example, aqueous suspensions containing the active compound in an aqueous medium in the presence of a non-toxic suspending agent such as sodium carboxy methylcellulose, and oily suspensions containing a compound of the present 10 invention in a suitable vegetable oil, for example arachis oil. The active compound may be formulated into granules with or without additional excipients. The granules may be ingested directly by the patient or they may be added to a suitable liquid carrier (for example, water) before ingestion. The granules may contain disintegrants, eg an effervescent couple formed from an acid and a 15 carbonate or bicarbonate salt to facilitate dispersion in the liquid medium. The therapeutically active compounds of formula I may be formulated into a composition which the patient retains in his mouth so that the active compound is administered through the mucosa of the mouth. 20 Dosage forms suitable for rectal administration are the known pharmaceutical forms for such administration, for example, suppositories with cocoa butter or polyethylene glycol bases. 25 Dosage forms suitable for parenteral administration are the known pharmaceutical forms for such administration, for example sterile suspensions or sterile solutions in a suitable solvent. Dosage forms for topical administration may comprise a matrix in which 30 the pharmacologically active compounds of the present invention are dispersed 5 SUBSTITUTE SHEET (RULE 26) WO 00/56323 PCT/USOO/07361 so that the compounds are held in contact with the skin in order to administer the compounds transdermally. A suitable transdermal composition may be prepared by mixing the pharmaceutically active compound with a topical vehicle, such as a mineral oil, petrolatum and/or a wax, e.g. paraffin wax or beeswax, together with 5 a potential transdermal accelerant such as dimethyl sulphoxide or propylene glycol. Alternatively the active compounds may be dispersed in a pharmaceutically acceptable cream, gel or ointment base. The amount of active compound contained in a topical formulation should be such that a therapeutically effective amount of the compound is delivered during the period of time for which 10 the topical formulation is intended to be on the skin. The therapeutically active compound of formula I may be formulated into a composition which is dispersed as an aerosol into the patients oral or nasal cavity. Such aerosols may be administered from a pump pack or from a 15 pressurised pack containing a volatile propellant. The therapeutically active compounds of formula I used in the method of the present invention may also be administered by continuous infusion either from an external source, for example by intravenous infusion or from a source of 20 the compound placed within the body. Internal sources include implanted reservoirs containing the compound to be infused which is continuously released for example by osmosis and implants which may be (a) liquid such as an oily suspension of the compound to be infused for example in the form of a very sparingly water-soluble derivative such as a dodecanoate salt or a lipophilic ester 25 or (b) solid in the form of an implanted support, for example of a synthetic resin or waxy material, for the compound to be infused. The support may be a single body containing all the compound or a series of several bodies each containing part of the compound to be delivered. The amount of active compound present in an internal source should be such that a therapeutically effective amount of the 30 compound is delivered over a long period of time. 6 SUBSTITUTE SHEET (RULE 26) WO 00/56323 PCT/USOO/07361 In some formulations it may be beneficial to use the compounds of the present invention in the form of particles of very small size, for example as obtained by fluid energy milling. 5 In the compositions of the present invention the active compound may, if desired, be associated with other compatible pharmacologically active ingredients. 10 The invention further provides the use of compounds of formula I in the manufacture of a medicament for treating certain cancers associated with obesity, for example colon cancer, breast cancer, endometrial cancer and gallbladder cancer. 15 In another aspect, the invention further provides a pharmaceutical composition for treating colon cancer, breast cancer, endometrial cancer and gallbladder cancer, comprising a compound of formula I in conjunction with a pharmaceutically acceptable diluent or carrier. 20 Monoamine reuptake inhibitors have been used to treat certain of the disorders described in the present invention. However, these compounds are known to suffer from a number of disadvantages. Firstly such compounds are not effective in all patients. Secondly where the compounds are effective they may not provide a complete cure of the disorder. Thirdly, there are many 25 undesirable side-effects known with this type of compound. Such side-effects include nausea, sexual dysfunction, light headedness, somnolence, sweating, tremor, dry mouth, asthenia, insomnia, diarrhoea, headache, vomiting, anxiety, drowsiness, dizziness, fever, rash or allergic reactions, arthralgia, myalgia, convulsions, hypomania and mania. 30 7 SUBSTITUTE SHEET (RULE 26) WO 00/56323 PCT/USOO/07361 Sibutramine (Formula 1, R 1 = CH 3 , R2 = CH 3 ) has a pharmacological profile which is unique amongst monoamine reuptake inhibitors. Through its pharmacologically active metabolites, (metabolite 1, R1 = H, R 2 = CH 3 in Formula I and metabolite 2, R 1 = H, R 2 = H in Formula I) sibutramine inhibits the reuptake 5 of all three monoamines differentiating it from serotonin (5-HT)-selective reuptake inhibitors, e.g. fluoxetine, noradenaline-selective reuptake inhibitors, e.g. desipramine, dopamine-selective reuptake inhibitors, e.g. bupropion, and serotonin-noradenaline reuptake inhibitors, e.g. venlafaxine (Table 1). It is this unique combination of pharmacological actions which renders sibutramine, and 10 the other compounds of formula 1, efficacious in the treatment of certain cancers associated with weight gain. The assays below are performed in a similar manner to those described in W098/41528. 15 TABLE Comparison of the in vitro monoamine reuptake inhibition profiles of Examples 1 and 2, and various reference monoamine reuptake inhibitors in rat brain tissue Ki (nM)
[
3 H]Noradenaline [3H]5-HT [ 3 H]Dopamine Example 1 3 18 24 Example 2 5 26 31 Bupropion 2590 18312 409 Desipramine 2 200 4853 Fluoxetine 320 11 2025 Venlafaxine 196 26 2594 The results are the means of >3 separate determinations 8 SUBSTITUTE SHEET (RULE 26) WO 00/56323 PCT/USOO/07361 Example 1 R 1 = H, R 2 = CH 3 in Formula I 5 Example 2 R 1 = H, R 2 = H in Formula I The efficacy of compounds of formula I in treating certain cancers is demonstrable through clinical trials in a relevant population set. 10 The invention has been described with reference to various specific embodiments. However, many variations and modifications may be made while remaining within the scope and spirit of the invention. 9 SUBSTITUTE SHEET (RULE 26)
Claims (20)
1. A method of treating cancers associated with obesity comprising administering to a human in need thereof a therapeutically effective amount of a 5 compound of formula I CH 3 H 3 CCHCH 2 CHNRR 2 C / including enantiomers and pharmaceutically acceptable salts thereof in which R 1 and R 2 are independently H or methyl, in conjunction with a pharmaceutically 10 acceptable diluent or carrier.
2. A method as claimed in claim 1 in which the cancer is colon cancer, breast cancer, endometrial cancer or gallbladder cancer. 15
3. A method as claimed in claim 1 or 2 wherein the compound of formula I is N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride.
4. A method as claimed in claim 1 or 2 wherein the compound of formula I is N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride 20 in the form of its monohydrate.
5. A method as claimed in claim 1 or 2 wherein the compound of formula 1 is (+) N-[1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N-methylamine. 25
6. A method as claimed in claim 1 or 2 wherein the compound of formula 1 is (-)-N-{l -[1 -(4-chlorophenyl)cyclobutyl-3-methylbutyl}-N-methylamine. 10 SUBSTITUTE SHEET (RULE 26) WO 00/56323 PCTIUSOO/07361
7. A method as claimed in claim 1 or 2 wherein the compound of formula 1 is (+)-l -[1 -(4-chlorophenyl)cyclobutyl]-3-methylbutylamine.
8. A method as claimed in claim 1 or 2 wherein the compound of formula 1 is 5 (-)-1 -[1 -(4-chlorophenyl)cyclobutyl]-3-methylbutylamine.
9 A method as claimed in claim 1 or 2 wherein the compound of formula 1 is (+)-N-{1 -[1 -(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N-N-dimethylamine.
10 10. The method as claimed in claim 1 or 2 wherein the compound of formula I is (-)-N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N-N-dimethylamine.
11. The method as claimed in claim 1 or 2 wherein the compound of formula I is (±)-N-{1-[1-(4-chlorophenyl)cyclobutyl-3-methylbutyl}-N-methylamine. 15
12. The method as claimed in claim 1 or 2 wherein the compound of formula I is (±)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine.
13. The method as claimed in claim 1 or 2 wherein the compound of formula I 20 is (±)-N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N-N-dimethylamine.
14. The use of a compound of formula I CH 3 H 3 CCHCH 2 C HNRR 2 Cl 25 including enantiomers and pharmaceutically acceptable salts thereof in which R 1 and R 2 are independently H or methyl, in the manufacture of a medicament for treating cancers associated with obesity. 11 SUBSTITUTE SHEET (RULE 26) WO 00/56323 PCTUSOO/07361
15. The use as claimed in claim 14 in which the cancer is colon cancer, breast cancer, endometrial cancer or gallbladder cancer. 5
16. The use as claimed in claim 14 or 15 in which the compound of formula I is N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride.
17. The use as claimed in claim 14 or 15 in which the compound of formula I 10 is N, N-dimethyl-1 -[1 -(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate.
18. A pharmaceutical composition for treating cancers associated with obesity, comprising a therapeutically effective amount of a compound of formula I 15 CH 3 H 3 CCHCH 2 CHNR 1 R 2 Cl / including enantiomers and pharmaceutically acceptable salts thereof in which R 1 and R 2 are independently H or methyl, in conjunction with a pharmaceutically acceptable diluent or carrier. 20
19. A pharmaceutical composition as claimed in claim 18 in which the compound of formula I is N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3 methylbutylamine hydrochloride. 25
20. A pharmaceutical composition as claimed in claim 18 in which the compound of formula I is N,N-dimethyl-1 -[1 -(4-chlorophenyl)cyclobutyl]-3 methylbutylamine hydrochloride monohydrate. 12 SUBSTITUTE SHEET (RULE 26)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12525099P | 1999-03-19 | 1999-03-19 | |
US60125250 | 1999-03-19 | ||
PCT/US2000/007361 WO2000056323A1 (en) | 1999-03-19 | 2000-03-17 | Treatment of certain cancers associated with weight gain |
Publications (1)
Publication Number | Publication Date |
---|---|
AU3632000A true AU3632000A (en) | 2000-10-09 |
Family
ID=22418838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU36320/00A Abandoned AU3632000A (en) | 1999-03-19 | 2000-03-17 | Treatment of certain cancers associated with weight gain |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP1171106A1 (en) |
JP (1) | JP2002539255A (en) |
KR (1) | KR20010113765A (en) |
CN (1) | CN1399545A (en) |
AU (1) | AU3632000A (en) |
BG (1) | BG105998A (en) |
BR (1) | BR0009161A (en) |
CA (1) | CA2367045A1 (en) |
CZ (1) | CZ20013281A3 (en) |
HU (1) | HUP0200497A2 (en) |
IL (1) | IL145239A0 (en) |
MX (1) | MXPA01009470A (en) |
NO (1) | NO20014478L (en) |
NZ (1) | NZ514012A (en) |
PL (1) | PL351958A1 (en) |
SK (1) | SK13372001A3 (en) |
TR (1) | TR200102692T2 (en) |
WO (1) | WO2000056323A1 (en) |
ZA (1) | ZA200107687B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004096202A1 (en) * | 2003-04-28 | 2004-11-11 | Cipla Limited | Pharmaceutical formulation comprising anti-obesity agent and acidulant |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8531071D0 (en) * | 1985-12-17 | 1986-01-29 | Boots Co Plc | Therapeutic compound |
US5459164A (en) * | 1994-02-03 | 1995-10-17 | Boots Pharmaceuticals, Inc. | Medical treatment |
-
2000
- 2000-03-17 PL PL00351958A patent/PL351958A1/en not_active Application Discontinuation
- 2000-03-17 EP EP00915015A patent/EP1171106A1/en not_active Withdrawn
- 2000-03-17 CA CA002367045A patent/CA2367045A1/en not_active Abandoned
- 2000-03-17 BR BR0009161-8A patent/BR0009161A/en not_active Application Discontinuation
- 2000-03-17 JP JP2000606228A patent/JP2002539255A/en not_active Withdrawn
- 2000-03-17 WO PCT/US2000/007361 patent/WO2000056323A1/en not_active Application Discontinuation
- 2000-03-17 MX MXPA01009470A patent/MXPA01009470A/en unknown
- 2000-03-17 HU HU0200497A patent/HUP0200497A2/en unknown
- 2000-03-17 CZ CZ20013281A patent/CZ20013281A3/en unknown
- 2000-03-17 AU AU36320/00A patent/AU3632000A/en not_active Abandoned
- 2000-03-17 NZ NZ514012A patent/NZ514012A/en not_active Application Discontinuation
- 2000-03-17 TR TR2001/02692T patent/TR200102692T2/en unknown
- 2000-03-17 KR KR1020017011855A patent/KR20010113765A/en not_active Application Discontinuation
- 2000-03-17 IL IL14523900A patent/IL145239A0/en unknown
- 2000-03-17 CN CN00807533A patent/CN1399545A/en active Pending
- 2000-03-17 SK SK1337-2001A patent/SK13372001A3/en unknown
-
2001
- 2001-09-14 NO NO20014478A patent/NO20014478L/en unknown
- 2001-09-18 ZA ZA200107687A patent/ZA200107687B/en unknown
- 2001-10-10 BG BG105998A patent/BG105998A/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2002539255A (en) | 2002-11-19 |
NO20014478L (en) | 2001-10-29 |
SK13372001A3 (en) | 2002-07-02 |
TR200102692T2 (en) | 2002-03-21 |
CN1399545A (en) | 2003-02-26 |
ZA200107687B (en) | 2002-12-18 |
KR20010113765A (en) | 2001-12-28 |
EP1171106A1 (en) | 2002-01-16 |
IL145239A0 (en) | 2002-06-30 |
PL351958A1 (en) | 2003-07-14 |
BR0009161A (en) | 2002-01-22 |
NZ514012A (en) | 2001-09-28 |
NO20014478D0 (en) | 2001-09-14 |
CA2367045A1 (en) | 2000-09-28 |
CZ20013281A3 (en) | 2002-07-17 |
WO2000056323A1 (en) | 2000-09-28 |
MXPA01009470A (en) | 2004-03-19 |
HUP0200497A2 (en) | 2002-08-28 |
BG105998A (en) | 2002-06-28 |
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Legal Events
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TC | Change of applicant's name (sec. 104) |
Owner name: ABBOTT GMBH AND CO. KG Free format text: FORMER NAME: KNOLL GMBH |