AU3498893A - 4-oxo-2 thioxoimidazolidine derivates as inhibitors of blood platelet aggregation - Google Patents

4-oxo-2 thioxoimidazolidine derivates as inhibitors of blood platelet aggregation

Info

Publication number
AU3498893A
AU3498893A AU34988/93A AU3498893A AU3498893A AU 3498893 A AU3498893 A AU 3498893A AU 34988/93 A AU34988/93 A AU 34988/93A AU 3498893 A AU3498893 A AU 3498893A AU 3498893 A AU3498893 A AU 3498893A
Authority
AU
Australia
Prior art keywords
derivates
thioxoimidazolidine
oxo
inhibitors
platelet aggregation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU34988/93A
Other versions
AU665617B2 (en
Inventor
Bernd Jablonka
Melitta Just
Jochen Knolle
Wolfgang Konig
Gerhard Zoller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Cassella AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella AG filed Critical Cassella AG
Publication of AU3498893A publication Critical patent/AU3498893A/en
Application granted granted Critical
Publication of AU665617B2 publication Critical patent/AU665617B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

4-oxo-2-thioxoimidazolidine derivates have the general formula (I), in which R?1 to R?4 and Y have the definition given in the description. Also disclosed is a process for preparing these derivates and their use as inhibitors of thrombocyte aggregation, of the formation of carcinoma cell metastases and of the binding of osteoclalsts to bone surfaces.
AU34988/93A 1992-03-07 1993-02-24 4-oxo-2 thioxoimidazolidine derivates as inhibitors of blood platelet aggregation Ceased AU665617B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4207254 1992-03-07
DE4207254A DE4207254A1 (en) 1992-03-07 1992-03-07 4-oxo-2-thioxoimidazolidin DERIVATIVES
PCT/EP1993/000424 WO1993018057A1 (en) 1992-03-07 1993-02-24 4-oxo-2 thioxoimidazolidine derivates as inhibitors of blood platelet aggregation

Publications (2)

Publication Number Publication Date
AU3498893A true AU3498893A (en) 1993-10-05
AU665617B2 AU665617B2 (en) 1996-01-11

Family

ID=6453475

Family Applications (1)

Application Number Title Priority Date Filing Date
AU34988/93A Ceased AU665617B2 (en) 1992-03-07 1993-02-24 4-oxo-2 thioxoimidazolidine derivates as inhibitors of blood platelet aggregation

Country Status (16)

Country Link
EP (1) EP0629211B1 (en)
JP (1) JP3495369B2 (en)
KR (1) KR100278532B1 (en)
AT (1) ATE169634T1 (en)
AU (1) AU665617B2 (en)
CA (1) CA2130174C (en)
CZ (1) CZ286327B6 (en)
DE (2) DE4207254A1 (en)
DK (1) DK0629211T3 (en)
ES (1) ES2121993T3 (en)
HU (1) HU217430B (en)
IL (1) IL104960A (en)
SK (1) SK107294A3 (en)
TW (1) TW255888B (en)
WO (1) WO1993018057A1 (en)
ZA (1) ZA931537B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU663213B2 (en) * 1992-08-28 1995-09-28 Cassella Aktiengesellschaft Imidazolidine derivatives
US6399620B1 (en) 1996-07-24 2002-06-04 Aventis Pharma S.A. Cycloalkyl derivatives as inhibitors of bone resporption and vitronectin receptor antagonists

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4427979A1 (en) * 1993-11-15 1996-02-15 Cassella Ag Substituted 5-ring heterocycles, their preparation and their use
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
US5563158A (en) * 1993-12-28 1996-10-08 The Dupont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
ZA963391B (en) * 1995-05-24 1997-10-29 Du Pont Merck Pharma Isoxazoline fibrinogen receptor antagonists.
TW418195B (en) * 1995-11-28 2001-01-11 American Home Prod 2-thioxo-imidazolidin-4-one derivatives
US5821372A (en) * 1995-11-28 1998-10-13 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives
US5599829A (en) * 1995-11-28 1997-02-04 American Home Products Corporation 2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives for increasing HDL cholesterol levels
US5554607A (en) * 1995-11-28 1996-09-10 American Home Products Corporation Use of 2-thioxo-imidazolin-4-one derivatives in the treatment of atherosclerosis
EP0796855B1 (en) 1996-03-20 2002-02-06 Hoechst Aktiengesellschaft Inhibitors of bone resorption and vitronectin receptor antagonists
DE19629817A1 (en) * 1996-07-24 1998-01-29 Hoechst Ag New imino derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
US5861517A (en) * 1996-11-21 1999-01-19 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives
US5663363A (en) * 1996-11-21 1997-09-02 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives
DE19741235A1 (en) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Novel imidazolidine derivatives, their preparation, their use and pharmaceutical compositions containing them
DE19741873A1 (en) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh New 5-ring heterocycles, their preparation, their use and pharmaceutical preparations containing them
DE19751251A1 (en) * 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituted imidazolidine derivatives, their manufacture, their use and pharmaceutical preparations containing them
DE19821483A1 (en) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh New imidazolidine derivatives useful as leukocyte adhesion and migration inhibitors and/or VLA-4 receptor antagonists for treating E.G. inflammatory and allergic disorders
DE19922462A1 (en) 1999-05-17 2000-11-23 Aventis Pharma Gmbh New phenylureidobenzyl-substituted spiro-imidazolidinedione derivatives, are inhibitors of leukocyte adhesion or migration or VLA-4 receptors, useful e.g. for treating inflammatory or allergic disease
DE10111877A1 (en) 2001-03-10 2002-09-12 Aventis Pharma Gmbh Novel imidazolidine derivatives, their preparation, their use and pharmaceutical compositions containing them
DE10137595A1 (en) 2001-08-01 2003-02-13 Aventis Pharma Gmbh New 3-alkylaminoalkyl-imdazolidin-4-one derivatives, are VLA-4 receptor and leukocyte adhesion and/or migration inhibitors, useful e.g. for treating inflammatory, allergic, autoimmune or cardiovascular disease
TWI339093B (en) 2007-08-24 2011-03-11 Asustek Comp Inc Cellular phone with shiftless motion function

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970225A (en) * 1990-02-13 1990-11-13 Bristol-Myers Squibb Company Imidazolidine carboxylic acids and esters as blood platelet aggregation inhibitors
DE4009506A1 (en) * 1990-03-24 1991-09-26 Hoechst Ag hydantoin

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU663213B2 (en) * 1992-08-28 1995-09-28 Cassella Aktiengesellschaft Imidazolidine derivatives
US6399620B1 (en) 1996-07-24 2002-06-04 Aventis Pharma S.A. Cycloalkyl derivatives as inhibitors of bone resporption and vitronectin receptor antagonists
US7348333B2 (en) 1996-07-24 2008-03-25 Aventis Pharma S.A. Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists

Also Published As

Publication number Publication date
HU217430B (en) 2000-01-28
JP3495369B2 (en) 2004-02-09
KR950700321A (en) 1995-01-16
TW255888B (en) 1995-09-01
ZA931537B (en) 1993-09-27
IL104960A0 (en) 1993-07-08
JPH07506567A (en) 1995-07-20
CZ216694A3 (en) 1995-04-12
EP0629211B1 (en) 1998-08-12
ES2121993T3 (en) 1998-12-16
KR100278532B1 (en) 2001-01-15
DE59308872D1 (en) 1998-09-17
AU665617B2 (en) 1996-01-11
EP0629211A1 (en) 1994-12-21
CZ286327B6 (en) 2000-03-15
DE4207254A1 (en) 1993-09-09
WO1993018057A1 (en) 1993-09-16
SK107294A3 (en) 1995-04-12
DK0629211T3 (en) 1999-05-17
ATE169634T1 (en) 1998-08-15
IL104960A (en) 1996-12-05
CA2130174A1 (en) 1993-09-16
HUT69716A (en) 1995-09-28
HU9402564D0 (en) 1994-11-28
CA2130174C (en) 2003-09-09

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired