AU3310189A - A monoclonal antibody against pseudomonas aeruginosa, the preparation and use thereof - Google Patents

A monoclonal antibody against pseudomonas aeruginosa, the preparation and use thereof

Info

Publication number
AU3310189A
AU3310189A AU33101/89A AU3310189A AU3310189A AU 3310189 A AU3310189 A AU 3310189A AU 33101/89 A AU33101/89 A AU 33101/89A AU 3310189 A AU3310189 A AU 3310189A AU 3310189 A AU3310189 A AU 3310189A
Authority
AU
Australia
Prior art keywords
monoclonal antibody
pseudomonas aeruginosa
preparation
antibody against
against pseudomonas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU33101/89A
Other versions
AU622446B2 (en
Inventor
Horst Domdey
Matthias Marget
Bernd-Ulrich Von Specht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of AU3310189A publication Critical patent/AU3310189A/en
Application granted granted Critical
Publication of AU622446B2 publication Critical patent/AU622446B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A monoclonal antibody (mAb) which cross-reacts with all 19 of the hitherto known Pseudomonas aeruginosa serotypes is described. The sequence of the variable regions is given. This mAb can be used as diagnostic aid, as active substance or as active substance carrier.
AU33101/89A 1988-04-19 1989-04-18 A monoclonal antibody against pseudomonas aeruginosa, the preparation and use thereof Ceased AU622446B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3813023 1988-04-19
DE3813023A DE3813023A1 (en) 1988-04-19 1988-04-19 MONOCLONAL ANTIBODY AGAINST PSEUDOMONAS AERUGINOSA, ITS PRODUCTION AND USE

Publications (2)

Publication Number Publication Date
AU3310189A true AU3310189A (en) 1989-10-26
AU622446B2 AU622446B2 (en) 1992-04-09

Family

ID=6352325

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33101/89A Ceased AU622446B2 (en) 1988-04-19 1989-04-18 A monoclonal antibody against pseudomonas aeruginosa, the preparation and use thereof

Country Status (10)

Country Link
EP (1) EP0338395B1 (en)
JP (1) JPH0213376A (en)
KR (1) KR890016165A (en)
AT (1) ATE116374T1 (en)
AU (1) AU622446B2 (en)
DE (2) DE3813023A1 (en)
DK (1) DK186289A (en)
ES (1) ES2065932T3 (en)
FI (1) FI891816A (en)
PT (1) PT90296B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013660A2 (en) * 1989-05-09 1990-11-15 Cetus Corporation Human monoclonal antibodies to sero-specific determinants of gram-negative bacteria
CA2038978A1 (en) * 1990-04-06 1991-10-07 Richard P. Darveau Antibodies for the treatment and diagnosis of pseudomonas aeruginosa infections
CA2627309A1 (en) * 2005-10-28 2007-05-03 Meiji Seika Kaisha, Ltd. Pseudomonas aeruginosa outer membrane protein pa5158
EP2220247A4 (en) 2007-11-16 2011-10-26 Nuvelo Inc Antibodies to lrp6
US9428583B2 (en) 2010-05-06 2016-08-30 Novartis Ag Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies
BR112012028326A2 (en) 2010-05-06 2017-03-21 Novartis Ag isolated multivalent antibody, isolated biparatopic antibodies, nucleic acid, vector, pharmaceutical composition, method of obtaining said antibodies and use thereof
TW201323442A (en) 2011-11-04 2013-06-16 Novartis Ag Low density lipoprotein-related protein 6 (LRP6)-half life extender constructs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0256713A3 (en) * 1986-08-06 1989-02-15 Merck & Co. Inc. Therapeutic human antipseudomonas aeruginosa antibodies
JPS63267295A (en) * 1986-12-03 1988-11-04 Sumitomo Chem Co Ltd Human antibody, antibody gene and corresponding recombinant
US4870161A (en) * 1987-09-25 1989-09-26 The United States Of America As Represented By The Department Of Health And Human Services Reagents and probes for distinguishing and isolating different GTP-binding proteins
DK8189A (en) * 1988-01-12 1989-07-13 Bunge Australia ANTIGEN-ANTIBODY CONJUGATES, THEIR PREPARATION AND USE
AU5435990A (en) * 1989-04-13 1990-11-05 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Monoclonal antibodies to human glutathione s transferase pi

Also Published As

Publication number Publication date
KR890016165A (en) 1989-11-28
ATE116374T1 (en) 1995-01-15
PT90296A (en) 1989-11-10
DE58908815D1 (en) 1995-02-09
DK186289A (en) 1989-12-18
JPH0213376A (en) 1990-01-17
EP0338395A2 (en) 1989-10-25
DK186289D0 (en) 1989-04-18
EP0338395A3 (en) 1990-03-28
ES2065932T3 (en) 1995-03-01
FI891816A0 (en) 1989-04-17
AU622446B2 (en) 1992-04-09
PT90296B (en) 1995-01-31
EP0338395B1 (en) 1994-12-28
DE3813023A1 (en) 1989-11-16
FI891816A (en) 1989-10-20

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