AU3259197A - 7-(3-Vinyl-1,4-piperazin-1-yl)-substituted quinolonecarboxylic acids - Google Patents
7-(3-Vinyl-1,4-piperazin-1-yl)-substituted quinolonecarboxylic acidsInfo
- Publication number
- AU3259197A AU3259197A AU32591/97A AU3259197A AU3259197A AU 3259197 A AU3259197 A AU 3259197A AU 32591/97 A AU32591/97 A AU 32591/97A AU 3259197 A AU3259197 A AU 3259197A AU 3259197 A AU3259197 A AU 3259197A
- Authority
- AU
- Australia
- Prior art keywords
- stands
- hydrogen
- carbon atoms
- methyl
- vinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The invention concerns new quinolone carbonic acids substituted by 7-(3-vinyl-1,4-piperazine-1-yl) of general formula (I) in which R<1> stands for hydrogen or alkyl optionally substituted by hydroxy, methoxy, amino, methylamino or dimethylamino with 1 to 4 carbon atoms or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl; R<2> stands for hydrogen or fluorine when at the same time R<4> is a different hydrogen or fluorine, or stands for amino, methyl or vinyl; R<3> stands for hydrogen, benzyl, alkyl with 1 to 3 carbon atoms, groups of -CH=CH-COOR<5>, -CH2CH2-COOR<5>, -CH2CH2CN, -CH2CH2COCH3, -CH2COCH3, in which R<5> stands for methyl or ethyl or stands for a group of the general structure R<6>-(NH-CHR<7>-CO)n- in which R<6> stands for hydrogen, alkyl with 1 to 3 carbon atoms or stands for the -COO-tertiary butyl group, R<7> stands for hydrogen, alkyl with 1 to 4 carbon atoms, hydroxyalkyl with 1 or 2 carbon atoms, CH2-phenyl, aminoalkyl or thioalkyl with 1 or 2 carbon atoms and n = 1 or 2; and R<4> stands for hydrogen or flourine when R<2> stands for amino, methyl or vinyl or stands for chlorine, methoxy, difluoromethoxy, CN or ethinyl. The invention also concerns a method for their use and their use in antibacterial substances.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19625988 | 1996-06-28 | ||
DE19625988 | 1996-06-28 | ||
DE19651687A DE19651687A1 (en) | 1996-06-28 | 1996-12-12 | 7- (3-Vinyl-1,4-piperazin-1-yl) substituted quinolonecarboxylic acids |
DE19651687 | 1996-12-12 | ||
PCT/EP1997/003116 WO1998000421A1 (en) | 1996-06-28 | 1997-06-16 | Quinolone carboxylic acids substituted by 7-(3-vinyl-1,4-piperazine-1-yl) |
Publications (2)
Publication Number | Publication Date |
---|---|
AU3259197A true AU3259197A (en) | 1998-01-21 |
AU720322B2 AU720322B2 (en) | 2000-05-25 |
Family
ID=26027015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU32591/97A Ceased AU720322B2 (en) | 1996-06-28 | 1997-06-16 | 7-(3-Vinyl-1,4-piperazin-1-yl)-substituted quinolonecarboxylic acids |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0907648B1 (en) |
JP (1) | JP2000513368A (en) |
AT (1) | ATE214060T1 (en) |
AU (1) | AU720322B2 (en) |
BR (1) | BR9710005A (en) |
CA (1) | CA2259217A1 (en) |
ES (1) | ES2171952T3 (en) |
NZ (1) | NZ333578A (en) |
TW (1) | TW415943B (en) |
WO (1) | WO1998000421A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10337191A1 (en) * | 2003-08-13 | 2005-03-17 | Bayer Healthcare Ag | New use of quinolone antibiotics |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0230053A3 (en) * | 1986-01-17 | 1988-03-30 | American Cyanamid Company | 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids |
-
1997
- 1997-06-12 TW TW086108070A patent/TW415943B/en not_active IP Right Cessation
- 1997-06-16 WO PCT/EP1997/003116 patent/WO1998000421A1/en not_active Application Discontinuation
- 1997-06-16 AT AT97928208T patent/ATE214060T1/en not_active IP Right Cessation
- 1997-06-16 CA CA002259217A patent/CA2259217A1/en not_active Abandoned
- 1997-06-16 ES ES97928208T patent/ES2171952T3/en not_active Expired - Lifetime
- 1997-06-16 BR BR9710005A patent/BR9710005A/en not_active IP Right Cessation
- 1997-06-16 AU AU32591/97A patent/AU720322B2/en not_active Ceased
- 1997-06-16 EP EP97928208A patent/EP0907648B1/en not_active Expired - Lifetime
- 1997-06-16 NZ NZ333578A patent/NZ333578A/en unknown
- 1997-06-16 JP JP10503795A patent/JP2000513368A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0907648A1 (en) | 1999-04-14 |
TW415943B (en) | 2000-12-21 |
AU720322B2 (en) | 2000-05-25 |
ATE214060T1 (en) | 2002-03-15 |
EP0907648B1 (en) | 2002-03-06 |
NZ333578A (en) | 2000-08-25 |
ES2171952T3 (en) | 2002-09-16 |
JP2000513368A (en) | 2000-10-10 |
BR9710005A (en) | 1999-08-10 |
CA2259217A1 (en) | 1998-01-08 |
WO1998000421A1 (en) | 1998-01-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FGA | Letters patent sealed or granted (standard patent) | ||
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |