AU3222195A - Organic compounds - Google Patents

Organic compounds

Info

Publication number
AU3222195A
AU3222195A AU32221/95A AU3222195A AU3222195A AU 3222195 A AU3222195 A AU 3222195A AU 32221/95 A AU32221/95 A AU 32221/95A AU 3222195 A AU3222195 A AU 3222195A AU 3222195 A AU3222195 A AU 3222195A
Authority
AU
Australia
Prior art keywords
pct
organic compounds
leu
sec
adhesion molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU32221/95A
Other versions
AU702332B2 (en
Inventor
Michael Morris Dreyfuss
Carolyn Ann Foster
Hans-Ulrich Naegeli
Berndt Oberhauser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9415168A external-priority patent/GB9415168D0/en
Priority claimed from GBGB9504332.9A external-priority patent/GB9504332D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of AU3222195A publication Critical patent/AU3222195A/en
Assigned to NOVARTIS AG reassignment NOVARTIS AG Amend patent request/document other than specification (104) Assignors: SANDOZ LTD.
Application granted granted Critical
Publication of AU702332B2 publication Critical patent/AU702332B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Neurosurgery (AREA)
  • AIDS & HIV (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)

Abstract

PCT No. PCT/EP95/02966 Sec. 371 Date Jan. 24, 1997 Sec. 102(e) Date Jan. 24, 1997 PCT Filed Jul. 26, 1995 PCT Pub. No. WO96/03430 PCT Pub. Date Feb. 8, 1996Cyclopeptolides of formula I wherein A, B, R, Leu, Leu, C, X and Y are as defined, are inhibitors of adhesion molecule expression and are thus useful for treatment of inflammatory and other diseases which involve increased levels of adhesion molecule expression.
AU32221/95A 1994-07-27 1995-07-26 Organic compounds Ceased AU702332B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9415168A GB9415168D0 (en) 1994-07-27 1994-07-27 Organic compounds
GB9415168 1994-07-27
GBGB9504332.9A GB9504332D0 (en) 1995-03-03 1995-03-03 Organic compounds
GB9504332 1995-03-03
PCT/EP1995/002966 WO1996003430A1 (en) 1994-07-27 1995-07-26 Organic compounds

Publications (2)

Publication Number Publication Date
AU3222195A true AU3222195A (en) 1996-02-22
AU702332B2 AU702332B2 (en) 1999-02-18

Family

ID=26305345

Family Applications (1)

Application Number Title Priority Date Filing Date
AU32221/95A Ceased AU702332B2 (en) 1994-07-27 1995-07-26 Organic compounds

Country Status (26)

Country Link
US (1) US6013627A (en)
EP (1) EP0775158B1 (en)
JP (1) JP3425763B2 (en)
KR (1) KR100378974B1 (en)
CN (1) CN1116304C (en)
AT (1) ATE187461T1 (en)
AU (1) AU702332B2 (en)
BR (1) BR9508342A (en)
CA (1) CA2192786C (en)
CY (1) CY2225B1 (en)
CZ (1) CZ289311B6 (en)
DE (1) DE69513837T2 (en)
DK (1) DK0775158T3 (en)
ES (1) ES2142490T3 (en)
FI (1) FI970279A (en)
GR (1) GR3032698T3 (en)
HK (1) HK1014011A1 (en)
HU (1) HUT77388A (en)
MX (1) MX9606494A (en)
NO (1) NO970340D0 (en)
NZ (1) NZ291168A (en)
PL (1) PL181990B1 (en)
PT (1) PT775158E (en)
RU (1) RU2155772C2 (en)
SK (1) SK11797A3 (en)
WO (1) WO1996003430A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
US6011136A (en) * 1995-11-21 2000-01-04 Novartis Ag Cyclopeptolides
WO1999014082A1 (en) 1996-09-18 1999-03-25 Minnesota Mining And Manufacturing Company Adhesively-bonded inflatable restraint and method of making
US6365619B1 (en) 1999-07-22 2002-04-02 Novartis Ag Treatment of arteriosclerosis
WO2001014387A1 (en) * 1999-08-24 2001-03-01 Ariad Gene Therapeutics, Inc. 28-epirapalogs
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
AU2002223649A1 (en) * 2000-10-27 2002-05-06 Novartis Ag Vegh inhibitors and their use
GB0028367D0 (en) * 2000-11-21 2001-01-03 Celltech Chiroscience Ltd Chemical compounds
GB0101598D0 (en) * 2001-01-22 2001-03-07 Novartis Ag Organic compounds
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
WO2009089549A1 (en) 2008-01-11 2009-07-16 Massachusetts Eye & Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
WO2014200659A1 (en) 2013-06-11 2014-12-18 Clontech Laboratories, Inc. Protein enriched microvesicles and methods of making and using the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4425428A (en) * 1982-04-08 1984-01-10 Monsanto Company Novel peptide and peptolide substrates for mammalian collagenase
US4443367A (en) * 1982-04-08 1984-04-17 Monsanto Company Peptide and peptolide substrates for mammalian collagenase
DE3851268T2 (en) * 1987-06-19 1995-01-26 Sandoz Ag Cyclic peptolides.
DE3832059A1 (en) * 1988-09-21 1990-03-29 Howaldtswerke Deutsche Werft DIVE DEPTH CONTROL BLOWOUT VALVE DEVICE
DE3832362A1 (en) * 1988-09-23 1990-03-29 Sandoz Ag NEW CYCLOPEPTOLIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE

Also Published As

Publication number Publication date
ATE187461T1 (en) 1999-12-15
KR100378974B1 (en) 2003-10-08
CA2192786A1 (en) 1996-02-08
CZ22197A3 (en) 1997-05-14
BR9508342A (en) 1997-10-21
JPH10504540A (en) 1998-05-06
NO970340L (en) 1997-01-27
GR3032698T3 (en) 2000-06-30
PT775158E (en) 2000-05-31
AU702332B2 (en) 1999-02-18
RU2155772C2 (en) 2000-09-10
US6013627A (en) 2000-01-11
CA2192786C (en) 2009-06-16
MX9606494A (en) 1997-03-29
CZ289311B6 (en) 2001-12-12
ES2142490T3 (en) 2000-04-16
DE69513837T2 (en) 2000-05-18
DE69513837D1 (en) 2000-01-13
PL181990B1 (en) 2001-10-31
HUT77388A (en) 1998-04-28
FI970279A0 (en) 1997-01-23
PL317349A1 (en) 1997-04-01
CY2225B1 (en) 2003-04-18
NZ291168A (en) 1998-06-26
EP0775158A1 (en) 1997-05-28
FI970279A (en) 1997-01-23
HK1014011A1 (en) 1999-09-17
CN1154705A (en) 1997-07-16
WO1996003430A1 (en) 1996-02-08
NO970340D0 (en) 1997-01-27
JP3425763B2 (en) 2003-07-14
DK0775158T3 (en) 2000-05-22
SK11797A3 (en) 1997-07-09
EP0775158B1 (en) 1999-12-08
CN1116304C (en) 2003-07-30

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired