AU3066789A - Optically pure r-(-)-niguldipine and its derivatives for treating tumorous diseases - Google Patents

Optically pure r-(-)-niguldipine and its derivatives for treating tumorous diseases

Info

Publication number
AU3066789A
AU3066789A AU30667/89A AU3066789A AU3066789A AU 3066789 A AU3066789 A AU 3066789A AU 30667/89 A AU30667/89 A AU 30667/89A AU 3066789 A AU3066789 A AU 3066789A AU 3066789 A AU3066789 A AU 3066789A
Authority
AU
Australia
Prior art keywords
niguldipine
derivatives
optically pure
tumorous diseases
treating tumorous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU30667/89A
Other versions
AU638205B2 (en
Inventor
Klaus-Dieter Beller
Rainer Boer
Dieter Flockerzi
Klaus Gietzen
Kurt Klemm
Karl Sanders
Christian Schudt
Wolf-Rudiger Ulrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of AU3066789A publication Critical patent/AU3066789A/en
Application granted granted Critical
Publication of AU638205B2 publication Critical patent/AU638205B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AU30667/89A 1988-02-19 1989-02-16 Optically pure r-(-)-niguldipine and its derivatives for treating tumorous diseases Ceased AU638205B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH62988 1988-02-19
CH630/88 1988-02-19
CH63088 1988-02-19

Publications (2)

Publication Number Publication Date
AU3066789A true AU3066789A (en) 1989-09-06
AU638205B2 AU638205B2 (en) 1993-06-24

Family

ID=25685170

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30667/89A Ceased AU638205B2 (en) 1988-02-19 1989-02-16 Optically pure r-(-)-niguldipine and its derivatives for treating tumorous diseases

Country Status (6)

Country Link
EP (1) EP0401256B1 (en)
JP (1) JPH03503525A (en)
AU (1) AU638205B2 (en)
DK (1) DK197490D0 (en)
HU (1) HU206181B (en)
WO (1) WO1989007443A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05507480A (en) * 1990-05-26 1993-10-28 ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング 1,4-dihydropyridine for use in overcoming drug resistance
DE4220616C2 (en) * 1992-06-24 1994-12-22 Byk Gulden Lomberg Chem Fab Dexniguldipine for intravenous administration
US5578611A (en) * 1992-11-13 1996-11-26 Synaptic Pharmaceutical Corporation Use of α-1C specific compounds to treat benign prostatic hyperplasia
US6015819A (en) * 1992-11-13 2000-01-18 Synaptic Pharmaceutical Corporation Use of alpha-1C specific compounds to treat benign prostatic hyperplasia
WO1994014809A1 (en) * 1992-12-23 1994-07-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Anellated uracil derivates
DE19624704A1 (en) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab New pyridylalkanoic acid amides
DE19624659A1 (en) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab New pyridylalkene and pyridylalkanoic acid amides
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19756261A1 (en) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab New aryl-substituted pyridylalkane, alkene and alkyarboxylic acid amides
DE19756212A1 (en) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab New cyclic imide-substituted pyridylalkane, alkene and alkyarboxylic acid amides
DE19756235A1 (en) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab New piperidinyl-substituted pyridylalkane alkene and alkane carboxylic acid amides
US6903118B1 (en) 1997-12-17 2005-06-07 Klinge Pharma Gmbh Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
EP1031564A1 (en) 1999-02-26 2000-08-30 Klinge Pharma GmbH Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4690935A (en) * 1983-03-31 1987-09-01 Wayne State University Inhibition of tumor growth and metastasis with calcium channel blocker compounds
JPS60212741A (en) * 1984-04-06 1985-10-25 Canon Inc Driving method of optical control element
FI83957C (en) * 1984-09-28 1991-09-25 Byk Gulden Lomberg Chem Fab FOERFARANDE FOER FRAMSTAELLNING AV NYA, TERAPEUTISKT ANVAENDBARA DIARYLFOERENINGAR.
EP0176956B1 (en) * 1984-09-28 1994-06-15 Byk Gulden Lomberg Chemische Fabrik GmbH Diaryl derivatives
DE3709796C2 (en) * 1986-03-27 1996-05-23 Byk Gulden Lomberg Chem Fab Process for the preparation of diarylpiperidyl-1,4-dihydropyridine dicarboxylic acid derivatives
DK142287A (en) * 1986-03-27 1987-09-28 Byk Gulden Lomberg Chem Fab OPTIC ACTIVE 1,4-DIHYDROPYRIDINE DERIVATIVES
NZ220022A (en) * 1986-04-22 1990-04-26 Byk Gulden Lomberg Chem Fab 1,4-dihydropyridine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
WO1989007443A1 (en) 1989-08-24
EP0401256B1 (en) 1993-05-26
EP0401256A1 (en) 1990-12-12
HU891455D0 (en) 1990-12-28
DK197490A (en) 1990-08-17
DK197490D0 (en) 1990-08-17
AU638205B2 (en) 1993-06-24
HU206181B (en) 1992-09-28
HUT55990A (en) 1991-07-29
JPH03503525A (en) 1991-08-08

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