AU3064989A - Modified gene sequences encoding modified tpa and products therefrom - Google Patents

Modified gene sequences encoding modified tpa and products therefrom

Info

Publication number
AU3064989A
AU3064989A AU30649/89A AU3064989A AU3064989A AU 3064989 A AU3064989 A AU 3064989A AU 30649/89 A AU30649/89 A AU 30649/89A AU 3064989 A AU3064989 A AU 3064989A AU 3064989 A AU3064989 A AU 3064989A
Authority
AU
Australia
Prior art keywords
sequence
transfected
host cell
dna sequence
cell transformed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU30649/89A
Other languages
English (en)
Inventor
David J. Livingston
William Markland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Integrated Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Integrated Genetics Inc filed Critical Integrated Genetics Inc
Publication of AU3064989A publication Critical patent/AU3064989A/en
Assigned to GENZYME CORPORATION reassignment GENZYME CORPORATION Alteration of Name(s) of Applicant(s) under S113 Assignors: INTEGRATED GENETICS INC.
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU30649/89A 1988-02-05 1989-02-03 Modified gene sequences encoding modified tpa and products therefrom Abandoned AU3064989A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15269188A 1988-02-05 1988-02-05
US152691 1988-02-05

Publications (1)

Publication Number Publication Date
AU3064989A true AU3064989A (en) 1989-08-25

Family

ID=22543990

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30649/89A Abandoned AU3064989A (en) 1988-02-05 1989-02-03 Modified gene sequences encoding modified tpa and products therefrom

Country Status (4)

Country Link
EP (1) EP0400054A1 (ja)
JP (1) JPH04500752A (ja)
AU (1) AU3064989A (ja)
WO (1) WO1989007145A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU619803B2 (en) * 1988-02-05 1992-02-06 Genzyme Corporation Rearranged tissue plasminogen activators and method for producing same

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2047702C (en) * 1989-03-06 2000-10-24 Joseph F. Sambrook Serpin resistant chymotrypsin superfamily proteases particularly pai-1 resistant t-pa, complementary inhibitor mutants; compositions; genes; expression
US5866413A (en) * 1989-03-06 1999-02-02 Board Of Regents Of The University Of Texas System Pai-1 mutants
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987003906A1 (en) * 1985-12-20 1987-07-02 The Upjohn Company Tissue plasminogen activator (tpa) analogs

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU619803B2 (en) * 1988-02-05 1992-02-06 Genzyme Corporation Rearranged tissue plasminogen activators and method for producing same

Also Published As

Publication number Publication date
WO1989007145A1 (en) 1989-08-10
EP0400054A1 (en) 1990-12-05
JPH04500752A (ja) 1992-02-13

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